diff --git a/DESCRIPTION b/DESCRIPTION
index f775fd8..41ce9e5 100755
--- a/DESCRIPTION
+++ b/DESCRIPTION
@@ -1,6 +1,6 @@
 Package: CSHstats
 Title: discussions and exercises on classical statistics for CSHL 2022
-Version: 0.0.33
+Version: 0.0.34
 Authors@R:
     person(given = "Vince",
            family = "Carey",
diff --git a/README.md b/README.md
index 68dfa7e..0419556 100644
--- a/README.md
+++ b/README.md
@@ -1,7 +1,6 @@
 # CSHstats
 R vignettes/pkgdown for elementary statistics for a summer course
 
-DRAFT!  Very preliminary as of 19 May 2022
 
 One view of the conceptual scheme of the course has three
 main vertices:
@@ -21,8 +20,10 @@ data science:
 - Exploratory data analysis and visualization
 - Hypothesis testing
 - Linear models
+- Ontology as a branch of information science
+- Brief introduction to convolutional neural nets
 
-MultiAssayExperiment applications with SingleCellMultimodal (for convenience)
+TBD: MultiAssayExperiment applications with SingleCellMultimodal (for convenience)
 
 [CITEseq](https://bioconductor.org/packages/release/data/experiment/vignettes/SingleCellMultiModal/inst/doc/CITEseq.html)
 
diff --git a/docs/404.html b/docs/404.html
index b27e695..486a4b6 100644
--- a/docs/404.html
+++ b/docs/404.html
@@ -7,75 +7,64 @@
 <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
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+
     <a class="navbar-brand me-2" href="index.html">CSHstats</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.0.33</small>
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+
 
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+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
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+<li><a class="dropdown-item" href="articles/S1_probability.html">S1_probability: Definitions and exercises</a></li>
+    <li><a class="dropdown-item" href="articles/S1b_hyper.html">S1a: A look at the hypergeometric distribution</a></li>
+    <li><a class="dropdown-item" href="articles/S2_EDA.html">S2_EDA: Exploratory data analysis and visualization</a></li>
+    <li><a class="dropdown-item" href="articles/S2a_PCAelem.html">S2a: Elements of PCA</a></li>
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+    <li><a class="dropdown-item" href="articles/S5_linear_models.html">S5_inference: FDR, linear models, and GLMs</a></li>
+    <li><a class="dropdown-item" href="articles/S5a_lmdiagnostics.html">S5a: Diagnostics of a differential gene expression exercise</a></li>
+    <li><a class="dropdown-item" href="articles/S5b_nonlin.html">S5b: hypothesis testing in nonlinear regression</a></li>
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+<ul class="navbar-nav">
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+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="search.json">
+</form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/vjcitn/CSHstats/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
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+
+      <h1>Page not found (404)</h1>
+
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 Content not found. Please use links in the navbar.
@@ -85,21 +74,19 @@
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
 </div>
 
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 </div>
 
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+
 
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diff --git a/docs/articles/S1_probability.html b/docs/articles/S1_probability.html
index 4704a1a..c63c0fa 100644
--- a/docs/articles/S1_probability.html
+++ b/docs/articles/S1_probability.html
@@ -5,83 +5,70 @@
 <meta charset="utf-8">
 <meta http-equiv="X-UA-Compatible" content="IE=edge">
 <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
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-      <img src="" class="logo" alt=""><h1>S1_probability: Definitions and exercises</h1>
+
+      <h1>S1_probability: Definitions and exercises</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S1_probability.Rmd" class="external-link"><code>vignettes/S1_probability.Rmd</code></a></small>
       <div class="d-none name"><code>S1_probability.Rmd</code></div>
@@ -669,7 +656,7 @@ <h4 id="histogram-probability-density-function">Histogram, probability density f
 <div class="sourceCode" id="cb58"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">dfun</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/approxfun.html" class="external-link">approxfun</a></span><span class="op">(</span><span class="va">dd</span><span class="op">$</span><span class="va">x</span>, <span class="va">dd</span><span class="op">$</span><span class="va">y</span><span class="op">)</span></span>
 <span><span class="fu"><a href="https://rdrr.io/r/stats/integrate.html" class="external-link">integrate</a></span><span class="op">(</span><span class="va">dfun</span>, <span class="fl">1000</span>, <span class="fl">1500</span><span class="op">)</span>  <span class="co"># density-based</span></span></code></pre></div>
-<pre><code><span><span class="co">## 0.4821651 with absolute error &lt; 1e-05</span></span></code></pre>
+<pre><code><span><span class="co">## 0.481747 with absolute error &lt; 1e-05</span></span></code></pre>
 <div class="sourceCode" id="cb60"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/mean.html" class="external-link">mean</a></span><span class="op">(</span><span class="va">yy1_ex</span> <span class="op">&gt;=</span><span class="fl">1000</span> <span class="op">&amp;</span> <span class="va">yy1_ex</span> <span class="op">&lt;=</span> <span class="fl">1500</span><span class="op">)</span> <span class="co"># empirical</span></span></code></pre></div>
 <pre><code><span><span class="co">## [1] 0.5316456</span></span></code></pre>
@@ -872,28 +859,26 @@ <h4 id="measures-of-correlation">Measures of correlation<a class="anchor" aria-l
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-      <img src="" class="logo" alt=""><h1>S1a: A look at the hypergeometric distribution</h1>
+
+      <h1>S1a: A look at the hypergeometric distribution</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S1b_hyper.Rmd" class="external-link"><code>vignettes/S1b_hyper.Rmd</code></a></small>
       <div class="d-none name"><code>S1b_hyper.Rmd</code></div>
@@ -98,7 +88,7 @@ <h2 id="the-null-situation">The “null” situation<a class="anchor" aria-label
 <span><span class="va">y</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/stats/Binomial.html" class="external-link">rbinom</a></span><span class="op">(</span><span class="fl">100</span>,<span class="fl">1</span>,<span class="fl">.4</span><span class="op">)</span></span></code></pre></div>
 <p>The 2x2 table relating exposure and outcome is:</p>
 <div class="sourceCode" id="cb2"><pre class="downlit sourceCode r">
-<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">gmodels</span><span class="op">)</span></span>
+<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/r-gregmisc/gmodels" class="external-link">gmodels</a></span><span class="op">)</span></span>
 <span><span class="fu"><a href="https://rdrr.io/pkg/gmodels/man/CrossTable.html" class="external-link">CrossTable</a></span><span class="op">(</span><span class="va">x</span>,<span class="va">y</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## </span></span>
 <span><span class="co">##  </span></span>
@@ -232,8 +222,8 @@ <h2 id="connection-to-the-hypergeometric-distribution">Connection to the hyperge
 <span><span class="co">## color  0 1</span></span>
 <span><span class="co">##   blue 4 1</span></span>
 <span><span class="co">##   red  3 2</span></span></code></pre>
-<p>The hypergeometric distribution is used to model such a situation, in which a draw of <span class="math inline">\(n\)</span> balls from an urn holding <span class="math inline">\(N\)</span> balls yields <span class="math inline">\(r\)</span> balls in a given condition. For this table, the probability of this draw is given by</p>
-<p><span class="math inline">\(\frac{{5 \choose 2} \cdot {5 \choose 1}}{10 \choose 3}\)</span>. In this case, Fisher’s test indicates no association between color and presence in the draw.</p>
+<p>The hypergeometric distribution is used to model such a situation, in which a draw of <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mi>n</mi><annotation encoding="application/x-tex">n</annotation></semantics></math> balls from an urn holding <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mi>N</mi><annotation encoding="application/x-tex">N</annotation></semantics></math> balls yields <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mi>r</mi><annotation encoding="application/x-tex">r</annotation></semantics></math> balls in a given condition. For this table, the probability of this draw is given by</p>
+<p><math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mfrac><mrow><mrow><mo stretchy="true" form="prefix">(</mo><mfrac linethickness="0"><mn>5</mn><mn>2</mn></mfrac><mo stretchy="true" form="postfix">)</mo></mrow><mo>⋅</mo><mrow><mo stretchy="true" form="prefix">(</mo><mfrac linethickness="0"><mn>5</mn><mn>1</mn></mfrac><mo stretchy="true" form="postfix">)</mo></mrow></mrow><mrow><mo stretchy="true" form="prefix">(</mo><mfrac linethickness="0"><mn>10</mn><mn>3</mn></mfrac><mo stretchy="true" form="postfix">)</mo></mrow></mfrac><annotation encoding="application/x-tex">\frac{{5 \choose 2} \cdot {5 \choose 1}}{10 \choose 3}</annotation></semantics></math>. In this case, Fisher’s test indicates no association between color and presence in the draw.</p>
 <div class="sourceCode" id="cb15"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/fisher.test.html" class="external-link">fisher.test</a></span><span class="op">(</span><span class="va">ta</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## </span></span>
@@ -298,34 +288,32 @@ <h2 id="connection-to-the-hypergeometric-distribution">Connection to the hyperge
 <span><span class="co">## (Dispersion parameter for binomial family taken to be 1)</span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">##     Null deviance: 4.8315e+00  on 1  degrees of freedom</span></span>
-<span><span class="co">## Residual deviance: 8.8818e-15  on 0  degrees of freedom</span></span>
+<span><span class="co">## Residual deviance: 1.5543e-14  on 0  degrees of freedom</span></span>
 <span><span class="co">## AIC: 12.268</span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Number of Fisher Scoring iterations: 3</span></span></code></pre>
 <p>Show that the log of the cross product ratio of the elements of ta2 is given by the coefficient of ‘red’ in the binomial model above.</p>
 </div>
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-      <img src="" class="logo" alt=""><h1>S2_EDA: Exploratory data analysis and visualization</h1>
+
+      <h1>S2_EDA: Exploratory data analysis and visualization</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S2_EDA.Rmd" class="external-link"><code>vignettes/S2_EDA.Rmd</code></a></small>
       <div class="d-none name"><code>S2_EDA.Rmd</code></div>
@@ -154,8 +141,8 @@ <h2 id="anscombes-quartet-statistics-that-miss-the-point">Anscombe’s quartet:
 <code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/rstudio/DT" class="external-link">DT</a></span><span class="op">)</span></span>
 <span><span class="fu"><a href="https://rdrr.io/r/utils/data.html" class="external-link">data</a></span><span class="op">(</span><span class="va">anscombe</span><span class="op">)</span></span>
 <span><span class="fu"><a href="https://rdrr.io/pkg/DT/man/datatable.html" class="external-link">datatable</a></span><span class="op">(</span><span class="va">anscombe</span><span class="op">)</span></span></code></pre></div>
-<div class="datatables html-widget html-fill-item-overflow-hidden html-fill-item" id="htmlwidget-3940ae21ff010d2016f9" style="width:100%;height:auto;"></div>
-<script type="application/json" data-for="htmlwidget-3940ae21ff010d2016f9">{"x":{"filter":"none","vertical":false,"data":[["1","2","3","4","5","6","7","8","9","10","11"],[10,8,13,9,11,14,6,4,12,7,5],[10,8,13,9,11,14,6,4,12,7,5],[10,8,13,9,11,14,6,4,12,7,5],[8,8,8,8,8,8,8,19,8,8,8],[8.039999999999999,6.95,7.58,8.81,8.33,9.960000000000001,7.24,4.26,10.84,4.82,5.68],[9.140000000000001,8.140000000000001,8.74,8.77,9.26,8.1,6.13,3.1,9.130000000000001,7.26,4.74],[7.46,6.77,12.74,7.11,7.81,8.84,6.08,5.39,8.15,6.42,5.73],[6.58,5.76,7.71,8.84,8.470000000000001,7.04,5.25,12.5,5.56,7.91,6.89]],"container":"<table class=\"display\">\n  <thead>\n    <tr>\n      <th> <\/th>\n      <th>x1<\/th>\n      <th>x2<\/th>\n      <th>x3<\/th>\n      <th>x4<\/th>\n      <th>y1<\/th>\n      <th>y2<\/th>\n      <th>y3<\/th>\n      <th>y4<\/th>\n    <\/tr>\n  <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2,3,4,5,6,7,8]},{"orderable":false,"targets":0}],"order":[],"autoWidth":false,"orderClasses":false}},"evals":[],"jsHooks":[]}</script><p>In our discussion of probability we provided definitions of
+<div class="datatables html-widget html-fill-item" id="htmlwidget-ac96cb3ee4656e2e9ec3" style="width:100%;height:auto;"></div>
+<script type="application/json" data-for="htmlwidget-ac96cb3ee4656e2e9ec3">{"x":{"filter":"none","vertical":false,"data":[["1","2","3","4","5","6","7","8","9","10","11"],[10,8,13,9,11,14,6,4,12,7,5],[10,8,13,9,11,14,6,4,12,7,5],[10,8,13,9,11,14,6,4,12,7,5],[8,8,8,8,8,8,8,19,8,8,8],[8.039999999999999,6.95,7.58,8.81,8.33,9.960000000000001,7.24,4.26,10.84,4.82,5.68],[9.140000000000001,8.140000000000001,8.74,8.77,9.26,8.1,6.13,3.1,9.130000000000001,7.26,4.74],[7.46,6.77,12.74,7.11,7.81,8.84,6.08,5.39,8.15,6.42,5.73],[6.58,5.76,7.71,8.84,8.470000000000001,7.04,5.25,12.5,5.56,7.91,6.89]],"container":"<table class=\"display\">\n  <thead>\n    <tr>\n      <th> <\/th>\n      <th>x1<\/th>\n      <th>x2<\/th>\n      <th>x3<\/th>\n      <th>x4<\/th>\n      <th>y1<\/th>\n      <th>y2<\/th>\n      <th>y3<\/th>\n      <th>y4<\/th>\n    <\/tr>\n  <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2,3,4,5,6,7,8]},{"orderable":false,"targets":0},{"name":" ","targets":0},{"name":"x1","targets":1},{"name":"x2","targets":2},{"name":"x3","targets":3},{"name":"x4","targets":4},{"name":"y1","targets":5},{"name":"y2","targets":6},{"name":"y3","targets":7},{"name":"y4","targets":8}],"order":[],"autoWidth":false,"orderClasses":false}},"evals":[],"jsHooks":[]}</script><p>In our discussion of probability we provided definitions of
 mean, variance, covariance, correlation. Here is a quick check
 on the means of the variables in the quartet.</p>
 <ul>
@@ -239,7 +226,7 @@ <h3 id="transformation">Transformation<a class="anchor" aria-label="anchor" href
 The origins of the procedure were reported to the Royal Statistical
 Society in 1964.</p>
 <div class="figure">
-<img src="boxcoxJRSS.jpg" alt="JRSS paper"><p class="caption">JRSS paper</p>
+<img src="boxcoxJRSS.jpg" alt=""><p class="caption">JRSS paper</p>
 </div>
 <p>The basic idea is that we can construct a series of functional
 transformations of a random variable to produce a distribution
@@ -338,28 +325,26 @@ <h2 id="visualizing-data-in-the-context-of-the-genome">Visualizing data in the c
 <p>We will use <code>https://vjcitn.shinyapps.io/tnt4dn8</code> to look at
 GWAS and eQTL data jointly.</p>
 </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
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@@ -0,0 +1 @@
+.container-fluid.crosstalk-bscols{margin-left:-30px;margin-right:-30px;white-space:normal}body>.container-fluid.crosstalk-bscols{margin-left:auto;margin-right:auto}.crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column{display:inline-block;padding-right:12px;vertical-align:top}@media only screen and (max-width: 480px){.crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column{display:block;padding-right:inherit}}.crosstalk-input{margin-bottom:15px}.crosstalk-input .control-label{margin-bottom:0;vertical-align:middle}.crosstalk-input input[type="checkbox"]{margin:4px 0 0;margin-top:1px;line-height:normal}.crosstalk-input .checkbox{position:relative;display:block;margin-top:10px;margin-bottom:10px}.crosstalk-input .checkbox>label{padding-left:20px;margin-bottom:0;font-weight:400;cursor:pointer}.crosstalk-input .checkbox input[type="checkbox"],.crosstalk-input .checkbox-inline input[type="checkbox"]{position:absolute;margin-top:2px;margin-left:-20px}.crosstalk-input .checkbox+.checkbox{margin-top:-5px}.crosstalk-input .checkbox-inline{position:relative;display:inline-block;padding-left:20px;margin-bottom:0;font-weight:400;vertical-align:middle;cursor:pointer}.crosstalk-input .checkbox-inline+.checkbox-inline{margin-top:0;margin-left:10px}
diff --git a/docs/articles/S2_EDA_files/crosstalk-1.2.1/js/crosstalk.js b/docs/articles/S2_EDA_files/crosstalk-1.2.1/js/crosstalk.js
new file mode 100644
index 0000000..fd9eb53
--- /dev/null
+++ b/docs/articles/S2_EDA_files/crosstalk-1.2.1/js/crosstalk.js
@@ -0,0 +1,1474 @@
+(function(){function e(t,n,r){function s(o,u){if(!n[o]){if(!t[o]){var a=typeof require=="function"&&require;if(!u&&a)return a(o,!0);if(i)return i(o,!0);var f=new Error("Cannot find module '"+o+"'");throw f.code="MODULE_NOT_FOUND",f}var l=n[o]={exports:{}};t[o][0].call(l.exports,function(e){var n=t[o][1][e];return s(n?n:e)},l,l.exports,e,t,n,r)}return n[o].exports}var i=typeof require=="function"&&require;for(var o=0;o<r.length;o++)s(r[o]);return s}return e})()({1:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+var Events = function () {
+  function Events() {
+    _classCallCheck(this, Events);
+
+    this._types = {};
+    this._seq = 0;
+  }
+
+  _createClass(Events, [{
+    key: "on",
+    value: function on(eventType, listener) {
+      var subs = this._types[eventType];
+      if (!subs) {
+        subs = this._types[eventType] = {};
+      }
+      var sub = "sub" + this._seq++;
+      subs[sub] = listener;
+      return sub;
+    }
+
+    // Returns false if no match, or string for sub name if matched
+
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      var subs = this._types[eventType];
+      if (typeof listener === "function") {
+        for (var key in subs) {
+          if (subs.hasOwnProperty(key)) {
+            if (subs[key] === listener) {
+              delete subs[key];
+              return key;
+            }
+          }
+        }
+        return false;
+      } else if (typeof listener === "string") {
+        if (subs && subs[listener]) {
+          delete subs[listener];
+          return listener;
+        }
+        return false;
+      } else {
+        throw new Error("Unexpected type for listener");
+      }
+    }
+  }, {
+    key: "trigger",
+    value: function trigger(eventType, arg, thisObj) {
+      var subs = this._types[eventType];
+      for (var key in subs) {
+        if (subs.hasOwnProperty(key)) {
+          subs[key].call(thisObj, arg);
+        }
+      }
+    }
+  }]);
+
+  return Events;
+}();
+
+exports.default = Events;
+
+},{}],2:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+exports.FilterHandle = undefined;
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _events = require("./events");
+
+var _events2 = _interopRequireDefault(_events);
+
+var _filterset = require("./filterset");
+
+var _filterset2 = _interopRequireDefault(_filterset);
+
+var _group = require("./group");
+
+var _group2 = _interopRequireDefault(_group);
+
+var _util = require("./util");
+
+var util = _interopRequireWildcard(_util);
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+function getFilterSet(group) {
+  var fsVar = group.var("filterset");
+  var result = fsVar.get();
+  if (!result) {
+    result = new _filterset2.default();
+    fsVar.set(result);
+  }
+  return result;
+}
+
+var id = 1;
+function nextId() {
+  return id++;
+}
+
+/**
+ * Use this class to contribute to, and listen for changes to, the filter set
+ * for the given group of widgets. Filter input controls should create one
+ * `FilterHandle` and only call {@link FilterHandle#set}. Output widgets that
+ * wish to displayed filtered data should create one `FilterHandle` and use
+ * the {@link FilterHandle#filteredKeys} property and listen for change
+ * events.
+ *
+ * If two (or more) `FilterHandle` instances in the same webpage share the
+ * same group name, they will contribute to a single "filter set". Each
+ * `FilterHandle` starts out with a `null` value, which means they take
+ * nothing away from the set of data that should be shown. To make a
+ * `FilterHandle` actually remove data from the filter set, set its value to
+ * an array of keys which should be displayed. Crosstalk will aggregate the
+ * various key arrays by finding their intersection; only keys that are
+ * present in all non-null filter handles are considered part of the filter
+ * set.
+ *
+ * @param {string} [group] - The name of the Crosstalk group, or if none,
+ *   null or undefined (or any other falsy value). This can be changed later
+ *   via the {@link FilterHandle#setGroup} method.
+ * @param {Object} [extraInfo] - An object whose properties will be copied to
+ *   the event object whenever an event is emitted.
+ */
+
+var FilterHandle = exports.FilterHandle = function () {
+  function FilterHandle(group, extraInfo) {
+    _classCallCheck(this, FilterHandle);
+
+    this._eventRelay = new _events2.default();
+    this._emitter = new util.SubscriptionTracker(this._eventRelay);
+
+    // Name of the group we're currently tracking, if any. Can change over time.
+    this._group = null;
+    // The filterSet that we're tracking, if any. Can change over time.
+    this._filterSet = null;
+    // The Var we're currently tracking, if any. Can change over time.
+    this._filterVar = null;
+    // The event handler subscription we currently have on var.on("change").
+    this._varOnChangeSub = null;
+
+    this._extraInfo = util.extend({ sender: this }, extraInfo);
+
+    this._id = "filter" + nextId();
+
+    this.setGroup(group);
+  }
+
+  /**
+   * Changes the Crosstalk group membership of this FilterHandle. If `set()` was
+   * previously called on this handle, switching groups will clear those keys
+   * from the old group's filter set. These keys will not be applied to the new
+   * group's filter set either. In other words, `setGroup()` effectively calls
+   * `clear()` before switching groups.
+   *
+   * @param {string} group - The name of the Crosstalk group, or null (or
+   *   undefined) to clear the group.
+   */
+
+
+  _createClass(FilterHandle, [{
+    key: "setGroup",
+    value: function setGroup(group) {
+      var _this = this;
+
+      // If group is unchanged, do nothing
+      if (this._group === group) return;
+      // Treat null, undefined, and other falsy values the same
+      if (!this._group && !group) return;
+
+      if (this._filterVar) {
+        this._filterVar.off("change", this._varOnChangeSub);
+        this.clear();
+        this._varOnChangeSub = null;
+        this._filterVar = null;
+        this._filterSet = null;
+      }
+
+      this._group = group;
+
+      if (group) {
+        group = (0, _group2.default)(group);
+        this._filterSet = getFilterSet(group);
+        this._filterVar = (0, _group2.default)(group).var("filter");
+        var sub = this._filterVar.on("change", function (e) {
+          _this._eventRelay.trigger("change", e, _this);
+        });
+        this._varOnChangeSub = sub;
+      }
+    }
+
+    /**
+     * Combine the given `extraInfo` (if any) with the handle's default
+     * `_extraInfo` (if any).
+     * @private
+     */
+
+  }, {
+    key: "_mergeExtraInfo",
+    value: function _mergeExtraInfo(extraInfo) {
+      return util.extend({}, this._extraInfo ? this._extraInfo : null, extraInfo ? extraInfo : null);
+    }
+
+    /**
+     * Close the handle. This clears this handle's contribution to the filter set,
+     * and unsubscribes all event listeners.
+     */
+
+  }, {
+    key: "close",
+    value: function close() {
+      this._emitter.removeAllListeners();
+      this.clear();
+      this.setGroup(null);
+    }
+
+    /**
+     * Clear this handle's contribution to the filter set.
+     *
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any options that were
+     *   passed into the `FilterHandle` constructor).
+     * 
+     * @fires FilterHandle#change
+     */
+
+  }, {
+    key: "clear",
+    value: function clear(extraInfo) {
+      if (!this._filterSet) return;
+      this._filterSet.clear(this._id);
+      this._onChange(extraInfo);
+    }
+
+    /**
+     * Set this handle's contribution to the filter set. This array should consist
+     * of the keys of the rows that _should_ be displayed; any keys that are not
+     * present in the array will be considered _filtered out_. Note that multiple
+     * `FilterHandle` instances in the group may each contribute an array of keys,
+     * and only those keys that appear in _all_ of the arrays make it through the
+     * filter.
+     *
+     * @param {string[]} keys - Empty array, or array of keys. To clear the
+     *   filter, don't pass an empty array; instead, use the
+     *   {@link FilterHandle#clear} method.
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any options that were
+     *   passed into the `FilterHandle` constructor).
+     * 
+     * @fires FilterHandle#change
+     */
+
+  }, {
+    key: "set",
+    value: function set(keys, extraInfo) {
+      if (!this._filterSet) return;
+      this._filterSet.update(this._id, keys);
+      this._onChange(extraInfo);
+    }
+
+    /**
+     * @return {string[]|null} - Either: 1) an array of keys that made it through
+     *   all of the `FilterHandle` instances, or, 2) `null`, which means no filter
+     *   is being applied (all data should be displayed).
+     */
+
+  }, {
+    key: "on",
+
+
+    /**
+     * Subscribe to events on this `FilterHandle`.
+     *
+     * @param {string} eventType - Indicates the type of events to listen to.
+     *   Currently, only `"change"` is supported.
+     * @param {FilterHandle~listener} listener - The callback function that
+     *   will be invoked when the event occurs.
+     * @return {string} - A token to pass to {@link FilterHandle#off} to cancel
+     *   this subscription.
+     */
+    value: function on(eventType, listener) {
+      return this._emitter.on(eventType, listener);
+    }
+
+    /**
+     * Cancel event subscriptions created by {@link FilterHandle#on}.
+     *
+     * @param {string} eventType - The type of event to unsubscribe.
+     * @param {string|FilterHandle~listener} listener - Either the callback
+     *   function previously passed into {@link FilterHandle#on}, or the
+     *   string that was returned from {@link FilterHandle#on}.
+     */
+
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      return this._emitter.off(eventType, listener);
+    }
+  }, {
+    key: "_onChange",
+    value: function _onChange(extraInfo) {
+      if (!this._filterSet) return;
+      this._filterVar.set(this._filterSet.value, this._mergeExtraInfo(extraInfo));
+    }
+
+    /**
+     * @callback FilterHandle~listener
+     * @param {Object} event - An object containing details of the event. For
+     *   `"change"` events, this includes the properties `value` (the new
+     *   value of the filter set, or `null` if no filter set is active),
+     *   `oldValue` (the previous value of the filter set), and `sender` (the
+     *   `FilterHandle` instance that made the change).
+     */
+
+  }, {
+    key: "filteredKeys",
+    get: function get() {
+      return this._filterSet ? this._filterSet.value : null;
+    }
+  }]);
+
+  return FilterHandle;
+}();
+
+/**
+ * @event FilterHandle#change
+ * @type {object}
+ * @property {object} value - The new value of the filter set, or `null`
+ *   if no filter set is active.
+ * @property {object} oldValue - The previous value of the filter set.
+ * @property {FilterHandle} sender - The `FilterHandle` instance that
+ *   changed the value.
+ */
+
+},{"./events":1,"./filterset":3,"./group":4,"./util":11}],3:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _util = require("./util");
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+function naturalComparator(a, b) {
+  if (a === b) {
+    return 0;
+  } else if (a < b) {
+    return -1;
+  } else if (a > b) {
+    return 1;
+  }
+}
+
+/**
+ * @private
+ */
+
+var FilterSet = function () {
+  function FilterSet() {
+    _classCallCheck(this, FilterSet);
+
+    this.reset();
+  }
+
+  _createClass(FilterSet, [{
+    key: "reset",
+    value: function reset() {
+      // Key: handle ID, Value: array of selected keys, or null
+      this._handles = {};
+      // Key: key string, Value: count of handles that include it
+      this._keys = {};
+      this._value = null;
+      this._activeHandles = 0;
+    }
+  }, {
+    key: "update",
+    value: function update(handleId, keys) {
+      if (keys !== null) {
+        keys = keys.slice(0); // clone before sorting
+        keys.sort(naturalComparator);
+      }
+
+      var _diffSortedLists = (0, _util.diffSortedLists)(this._handles[handleId], keys),
+          added = _diffSortedLists.added,
+          removed = _diffSortedLists.removed;
+
+      this._handles[handleId] = keys;
+
+      for (var i = 0; i < added.length; i++) {
+        this._keys[added[i]] = (this._keys[added[i]] || 0) + 1;
+      }
+      for (var _i = 0; _i < removed.length; _i++) {
+        this._keys[removed[_i]]--;
+      }
+
+      this._updateValue(keys);
+    }
+
+    /**
+     * @param {string[]} keys Sorted array of strings that indicate
+     * a superset of possible keys.
+     * @private
+     */
+
+  }, {
+    key: "_updateValue",
+    value: function _updateValue() {
+      var keys = arguments.length > 0 && arguments[0] !== undefined ? arguments[0] : this._allKeys;
+
+      var handleCount = Object.keys(this._handles).length;
+      if (handleCount === 0) {
+        this._value = null;
+      } else {
+        this._value = [];
+        for (var i = 0; i < keys.length; i++) {
+          var count = this._keys[keys[i]];
+          if (count === handleCount) {
+            this._value.push(keys[i]);
+          }
+        }
+      }
+    }
+  }, {
+    key: "clear",
+    value: function clear(handleId) {
+      if (typeof this._handles[handleId] === "undefined") {
+        return;
+      }
+
+      var keys = this._handles[handleId];
+      if (!keys) {
+        keys = [];
+      }
+
+      for (var i = 0; i < keys.length; i++) {
+        this._keys[keys[i]]--;
+      }
+      delete this._handles[handleId];
+
+      this._updateValue();
+    }
+  }, {
+    key: "value",
+    get: function get() {
+      return this._value;
+    }
+  }, {
+    key: "_allKeys",
+    get: function get() {
+      var allKeys = Object.keys(this._keys);
+      allKeys.sort(naturalComparator);
+      return allKeys;
+    }
+  }]);
+
+  return FilterSet;
+}();
+
+exports.default = FilterSet;
+
+},{"./util":11}],4:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _typeof = typeof Symbol === "function" && typeof Symbol.iterator === "symbol" ? function (obj) { return typeof obj; } : function (obj) { return obj && typeof Symbol === "function" && obj.constructor === Symbol && obj !== Symbol.prototype ? "symbol" : typeof obj; };
+
+exports.default = group;
+
+var _var2 = require("./var");
+
+var _var3 = _interopRequireDefault(_var2);
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+// Use a global so that multiple copies of crosstalk.js can be loaded and still
+// have groups behave as singletons across all copies.
+global.__crosstalk_groups = global.__crosstalk_groups || {};
+var groups = global.__crosstalk_groups;
+
+function group(groupName) {
+  if (groupName && typeof groupName === "string") {
+    if (!groups.hasOwnProperty(groupName)) {
+      groups[groupName] = new Group(groupName);
+    }
+    return groups[groupName];
+  } else if ((typeof groupName === "undefined" ? "undefined" : _typeof(groupName)) === "object" && groupName._vars && groupName.var) {
+    // Appears to already be a group object
+    return groupName;
+  } else if (Array.isArray(groupName) && groupName.length == 1 && typeof groupName[0] === "string") {
+    return group(groupName[0]);
+  } else {
+    throw new Error("Invalid groupName argument");
+  }
+}
+
+var Group = function () {
+  function Group(name) {
+    _classCallCheck(this, Group);
+
+    this.name = name;
+    this._vars = {};
+  }
+
+  _createClass(Group, [{
+    key: "var",
+    value: function _var(name) {
+      if (!name || typeof name !== "string") {
+        throw new Error("Invalid var name");
+      }
+
+      if (!this._vars.hasOwnProperty(name)) this._vars[name] = new _var3.default(this, name);
+      return this._vars[name];
+    }
+  }, {
+    key: "has",
+    value: function has(name) {
+      if (!name || typeof name !== "string") {
+        throw new Error("Invalid var name");
+      }
+
+      return this._vars.hasOwnProperty(name);
+    }
+  }]);
+
+  return Group;
+}();
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./var":12}],5:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _group = require("./group");
+
+var _group2 = _interopRequireDefault(_group);
+
+var _selection = require("./selection");
+
+var _filter = require("./filter");
+
+var _input = require("./input");
+
+require("./input_selectize");
+
+require("./input_checkboxgroup");
+
+require("./input_slider");
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+var defaultGroup = (0, _group2.default)("default");
+
+function var_(name) {
+  return defaultGroup.var(name);
+}
+
+function has(name) {
+  return defaultGroup.has(name);
+}
+
+if (global.Shiny) {
+  global.Shiny.addCustomMessageHandler("update-client-value", function (message) {
+    if (typeof message.group === "string") {
+      (0, _group2.default)(message.group).var(message.name).set(message.value);
+    } else {
+      var_(message.name).set(message.value);
+    }
+  });
+}
+
+var crosstalk = {
+  group: _group2.default,
+  var: var_,
+  has: has,
+  SelectionHandle: _selection.SelectionHandle,
+  FilterHandle: _filter.FilterHandle,
+  bind: _input.bind
+};
+
+/**
+ * @namespace crosstalk
+ */
+exports.default = crosstalk;
+
+global.crosstalk = crosstalk;
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./group":4,"./input":6,"./input_checkboxgroup":7,"./input_selectize":8,"./input_slider":9,"./selection":10}],6:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+exports.register = register;
+exports.bind = bind;
+var $ = global.jQuery;
+
+var bindings = {};
+
+function register(reg) {
+  bindings[reg.className] = reg;
+  if (global.document && global.document.readyState !== "complete") {
+    $(function () {
+      bind();
+    });
+  } else if (global.document) {
+    setTimeout(bind, 100);
+  }
+}
+
+function bind() {
+  Object.keys(bindings).forEach(function (className) {
+    var binding = bindings[className];
+    $("." + binding.className).not(".crosstalk-input-bound").each(function (i, el) {
+      bindInstance(binding, el);
+    });
+  });
+}
+
+// Escape jQuery identifier
+function $escape(val) {
+  return val.replace(/([!"#$%&'()*+,./:;<=>?@[\\\]^`{|}~])/g, "\\$1");
+}
+
+function bindEl(el) {
+  var $el = $(el);
+  Object.keys(bindings).forEach(function (className) {
+    if ($el.hasClass(className) && !$el.hasClass("crosstalk-input-bound")) {
+      var binding = bindings[className];
+      bindInstance(binding, el);
+    }
+  });
+}
+
+function bindInstance(binding, el) {
+  var jsonEl = $(el).find("script[type='application/json'][data-for='" + $escape(el.id) + "']");
+  var data = JSON.parse(jsonEl[0].innerText);
+
+  var instance = binding.factory(el, data);
+  $(el).data("crosstalk-instance", instance);
+  $(el).addClass("crosstalk-input-bound");
+}
+
+if (global.Shiny) {
+  var inputBinding = new global.Shiny.InputBinding();
+  var _$ = global.jQuery;
+  _$.extend(inputBinding, {
+    find: function find(scope) {
+      return _$(scope).find(".crosstalk-input");
+    },
+    initialize: function initialize(el) {
+      if (!_$(el).hasClass("crosstalk-input-bound")) {
+        bindEl(el);
+      }
+    },
+    getId: function getId(el) {
+      return el.id;
+    },
+    getValue: function getValue(el) {},
+    setValue: function setValue(el, value) {},
+    receiveMessage: function receiveMessage(el, data) {},
+    subscribe: function subscribe(el, callback) {
+      _$(el).data("crosstalk-instance").resume();
+    },
+    unsubscribe: function unsubscribe(el) {
+      _$(el).data("crosstalk-instance").suspend();
+    }
+  });
+  global.Shiny.inputBindings.register(inputBinding, "crosstalk.inputBinding");
+}
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{}],7:[function(require,module,exports){
+(function (global){
+"use strict";
+
+var _input = require("./input");
+
+var input = _interopRequireWildcard(_input);
+
+var _filter = require("./filter");
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+var $ = global.jQuery;
+
+input.register({
+  className: "crosstalk-input-checkboxgroup",
+
+  factory: function factory(el, data) {
+    /*
+     * map: {"groupA": ["keyA", "keyB", ...], ...}
+     * group: "ct-groupname"
+     */
+    var ctHandle = new _filter.FilterHandle(data.group);
+
+    var lastKnownKeys = void 0;
+    var $el = $(el);
+    $el.on("change", "input[type='checkbox']", function () {
+      var checked = $el.find("input[type='checkbox']:checked");
+      if (checked.length === 0) {
+        lastKnownKeys = null;
+        ctHandle.clear();
+      } else {
+        var keys = {};
+        checked.each(function () {
+          data.map[this.value].forEach(function (key) {
+            keys[key] = true;
+          });
+        });
+        var keyArray = Object.keys(keys);
+        keyArray.sort();
+        lastKnownKeys = keyArray;
+        ctHandle.set(keyArray);
+      }
+    });
+
+    return {
+      suspend: function suspend() {
+        ctHandle.clear();
+      },
+      resume: function resume() {
+        if (lastKnownKeys) ctHandle.set(lastKnownKeys);
+      }
+    };
+  }
+});
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./input":6}],8:[function(require,module,exports){
+(function (global){
+"use strict";
+
+var _input = require("./input");
+
+var input = _interopRequireWildcard(_input);
+
+var _util = require("./util");
+
+var util = _interopRequireWildcard(_util);
+
+var _filter = require("./filter");
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+var $ = global.jQuery;
+
+input.register({
+  className: "crosstalk-input-select",
+
+  factory: function factory(el, data) {
+    /*
+     * items: {value: [...], label: [...]}
+     * map: {"groupA": ["keyA", "keyB", ...], ...}
+     * group: "ct-groupname"
+     */
+
+    var first = [{ value: "", label: "(All)" }];
+    var items = util.dataframeToD3(data.items);
+    var opts = {
+      options: first.concat(items),
+      valueField: "value",
+      labelField: "label",
+      searchField: "label"
+    };
+
+    var select = $(el).find("select")[0];
+
+    var selectize = $(select).selectize(opts)[0].selectize;
+
+    var ctHandle = new _filter.FilterHandle(data.group);
+
+    var lastKnownKeys = void 0;
+    selectize.on("change", function () {
+      if (selectize.items.length === 0) {
+        lastKnownKeys = null;
+        ctHandle.clear();
+      } else {
+        var keys = {};
+        selectize.items.forEach(function (group) {
+          data.map[group].forEach(function (key) {
+            keys[key] = true;
+          });
+        });
+        var keyArray = Object.keys(keys);
+        keyArray.sort();
+        lastKnownKeys = keyArray;
+        ctHandle.set(keyArray);
+      }
+    });
+
+    return {
+      suspend: function suspend() {
+        ctHandle.clear();
+      },
+      resume: function resume() {
+        if (lastKnownKeys) ctHandle.set(lastKnownKeys);
+      }
+    };
+  }
+});
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./input":6,"./util":11}],9:[function(require,module,exports){
+(function (global){
+"use strict";
+
+var _slicedToArray = function () { function sliceIterator(arr, i) { var _arr = []; var _n = true; var _d = false; var _e = undefined; try { for (var _i = arr[Symbol.iterator](), _s; !(_n = (_s = _i.next()).done); _n = true) { _arr.push(_s.value); if (i && _arr.length === i) break; } } catch (err) { _d = true; _e = err; } finally { try { if (!_n && _i["return"]) _i["return"](); } finally { if (_d) throw _e; } } return _arr; } return function (arr, i) { if (Array.isArray(arr)) { return arr; } else if (Symbol.iterator in Object(arr)) { return sliceIterator(arr, i); } else { throw new TypeError("Invalid attempt to destructure non-iterable instance"); } }; }();
+
+var _input = require("./input");
+
+var input = _interopRequireWildcard(_input);
+
+var _filter = require("./filter");
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+var $ = global.jQuery;
+var strftime = global.strftime;
+
+input.register({
+  className: "crosstalk-input-slider",
+
+  factory: function factory(el, data) {
+    /*
+     * map: {"groupA": ["keyA", "keyB", ...], ...}
+     * group: "ct-groupname"
+     */
+    var ctHandle = new _filter.FilterHandle(data.group);
+
+    var opts = {};
+    var $el = $(el).find("input");
+    var dataType = $el.data("data-type");
+    var timeFormat = $el.data("time-format");
+    var round = $el.data("round");
+    var timeFormatter = void 0;
+
+    // Set up formatting functions
+    if (dataType === "date") {
+      timeFormatter = strftime.utc();
+      opts.prettify = function (num) {
+        return timeFormatter(timeFormat, new Date(num));
+      };
+    } else if (dataType === "datetime") {
+      var timezone = $el.data("timezone");
+      if (timezone) timeFormatter = strftime.timezone(timezone);else timeFormatter = strftime;
+
+      opts.prettify = function (num) {
+        return timeFormatter(timeFormat, new Date(num));
+      };
+    } else if (dataType === "number") {
+      if (typeof round !== "undefined") opts.prettify = function (num) {
+        var factor = Math.pow(10, round);
+        return Math.round(num * factor) / factor;
+      };
+    }
+
+    $el.ionRangeSlider(opts);
+
+    function getValue() {
+      var result = $el.data("ionRangeSlider").result;
+
+      // Function for converting numeric value from slider to appropriate type.
+      var convert = void 0;
+      var dataType = $el.data("data-type");
+      if (dataType === "date") {
+        convert = function convert(val) {
+          return formatDateUTC(new Date(+val));
+        };
+      } else if (dataType === "datetime") {
+        convert = function convert(val) {
+          // Convert ms to s
+          return +val / 1000;
+        };
+      } else {
+        convert = function convert(val) {
+          return +val;
+        };
+      }
+
+      if ($el.data("ionRangeSlider").options.type === "double") {
+        return [convert(result.from), convert(result.to)];
+      } else {
+        return convert(result.from);
+      }
+    }
+
+    var lastKnownKeys = null;
+
+    $el.on("change.crosstalkSliderInput", function (event) {
+      if (!$el.data("updating") && !$el.data("animating")) {
+        var _getValue = getValue(),
+            _getValue2 = _slicedToArray(_getValue, 2),
+            from = _getValue2[0],
+            to = _getValue2[1];
+
+        var keys = [];
+        for (var i = 0; i < data.values.length; i++) {
+          var val = data.values[i];
+          if (val >= from && val <= to) {
+            keys.push(data.keys[i]);
+          }
+        }
+        keys.sort();
+        ctHandle.set(keys);
+        lastKnownKeys = keys;
+      }
+    });
+
+    // let $el = $(el);
+    // $el.on("change", "input[type="checkbox"]", function() {
+    //   let checked = $el.find("input[type="checkbox"]:checked");
+    //   if (checked.length === 0) {
+    //     ctHandle.clear();
+    //   } else {
+    //     let keys = {};
+    //     checked.each(function() {
+    //       data.map[this.value].forEach(function(key) {
+    //         keys[key] = true;
+    //       });
+    //     });
+    //     let keyArray = Object.keys(keys);
+    //     keyArray.sort();
+    //     ctHandle.set(keyArray);
+    //   }
+    // });
+
+    return {
+      suspend: function suspend() {
+        ctHandle.clear();
+      },
+      resume: function resume() {
+        if (lastKnownKeys) ctHandle.set(lastKnownKeys);
+      }
+    };
+  }
+});
+
+// Convert a number to a string with leading zeros
+function padZeros(n, digits) {
+  var str = n.toString();
+  while (str.length < digits) {
+    str = "0" + str;
+  }return str;
+}
+
+// Given a Date object, return a string in yyyy-mm-dd format, using the
+// UTC date. This may be a day off from the date in the local time zone.
+function formatDateUTC(date) {
+  if (date instanceof Date) {
+    return date.getUTCFullYear() + "-" + padZeros(date.getUTCMonth() + 1, 2) + "-" + padZeros(date.getUTCDate(), 2);
+  } else {
+    return null;
+  }
+}
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./input":6}],10:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+exports.SelectionHandle = undefined;
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _events = require("./events");
+
+var _events2 = _interopRequireDefault(_events);
+
+var _group = require("./group");
+
+var _group2 = _interopRequireDefault(_group);
+
+var _util = require("./util");
+
+var util = _interopRequireWildcard(_util);
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+/**
+ * Use this class to read and write (and listen for changes to) the selection
+ * for a Crosstalk group. This is intended to be used for linked brushing.
+ *
+ * If two (or more) `SelectionHandle` instances in the same webpage share the
+ * same group name, they will share the same state. Setting the selection using
+ * one `SelectionHandle` instance will result in the `value` property instantly
+ * changing across the others, and `"change"` event listeners on all instances
+ * (including the one that initiated the sending) will fire.
+ *
+ * @param {string} [group] - The name of the Crosstalk group, or if none,
+ *   null or undefined (or any other falsy value). This can be changed later
+ *   via the [SelectionHandle#setGroup](#setGroup) method.
+ * @param {Object} [extraInfo] - An object whose properties will be copied to
+ *   the event object whenever an event is emitted.
+ */
+var SelectionHandle = exports.SelectionHandle = function () {
+  function SelectionHandle() {
+    var group = arguments.length > 0 && arguments[0] !== undefined ? arguments[0] : null;
+    var extraInfo = arguments.length > 1 && arguments[1] !== undefined ? arguments[1] : null;
+
+    _classCallCheck(this, SelectionHandle);
+
+    this._eventRelay = new _events2.default();
+    this._emitter = new util.SubscriptionTracker(this._eventRelay);
+
+    // Name of the group we're currently tracking, if any. Can change over time.
+    this._group = null;
+    // The Var we're currently tracking, if any. Can change over time.
+    this._var = null;
+    // The event handler subscription we currently have on var.on("change").
+    this._varOnChangeSub = null;
+
+    this._extraInfo = util.extend({ sender: this }, extraInfo);
+
+    this.setGroup(group);
+  }
+
+  /**
+   * Changes the Crosstalk group membership of this SelectionHandle. The group
+   * being switched away from (if any) will not have its selection value
+   * modified as a result of calling `setGroup`, even if this handle was the
+   * most recent handle to set the selection of the group.
+   *
+   * The group being switched to (if any) will also not have its selection value
+   * modified as a result of calling `setGroup`. If you want to set the
+   * selection value of the new group, call `set` explicitly.
+   *
+   * @param {string} group - The name of the Crosstalk group, or null (or
+   *   undefined) to clear the group.
+   */
+
+
+  _createClass(SelectionHandle, [{
+    key: "setGroup",
+    value: function setGroup(group) {
+      var _this = this;
+
+      // If group is unchanged, do nothing
+      if (this._group === group) return;
+      // Treat null, undefined, and other falsy values the same
+      if (!this._group && !group) return;
+
+      if (this._var) {
+        this._var.off("change", this._varOnChangeSub);
+        this._var = null;
+        this._varOnChangeSub = null;
+      }
+
+      this._group = group;
+
+      if (group) {
+        this._var = (0, _group2.default)(group).var("selection");
+        var sub = this._var.on("change", function (e) {
+          _this._eventRelay.trigger("change", e, _this);
+        });
+        this._varOnChangeSub = sub;
+      }
+    }
+
+    /**
+     * Retrieves the current selection for the group represented by this
+     * `SelectionHandle`.
+     *
+     * - If no selection is active, then this value will be falsy.
+     * - If a selection is active, but no data points are selected, then this
+     *   value will be an empty array.
+     * - If a selection is active, and data points are selected, then the keys
+     *   of the selected data points will be present in the array.
+     */
+
+  }, {
+    key: "_mergeExtraInfo",
+
+
+    /**
+     * Combines the given `extraInfo` (if any) with the handle's default
+     * `_extraInfo` (if any).
+     * @private
+     */
+    value: function _mergeExtraInfo(extraInfo) {
+      // Important incidental effect: shallow clone is returned
+      return util.extend({}, this._extraInfo ? this._extraInfo : null, extraInfo ? extraInfo : null);
+    }
+
+    /**
+     * Overwrites the current selection for the group, and raises the `"change"`
+     * event among all of the group's '`SelectionHandle` instances (including
+     * this one).
+     *
+     * @fires SelectionHandle#change
+     * @param {string[]} selectedKeys - Falsy, empty array, or array of keys (see
+     *   {@link SelectionHandle#value}).
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any options that were
+     *   passed into the `SelectionHandle` constructor).
+     */
+
+  }, {
+    key: "set",
+    value: function set(selectedKeys, extraInfo) {
+      if (this._var) this._var.set(selectedKeys, this._mergeExtraInfo(extraInfo));
+    }
+
+    /**
+     * Overwrites the current selection for the group, and raises the `"change"`
+     * event among all of the group's '`SelectionHandle` instances (including
+     * this one).
+     *
+     * @fires SelectionHandle#change
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any that were passed
+     *   into the `SelectionHandle` constructor).
+     */
+
+  }, {
+    key: "clear",
+    value: function clear(extraInfo) {
+      if (this._var) this.set(void 0, this._mergeExtraInfo(extraInfo));
+    }
+
+    /**
+     * Subscribes to events on this `SelectionHandle`.
+     *
+     * @param {string} eventType - Indicates the type of events to listen to.
+     *   Currently, only `"change"` is supported.
+     * @param {SelectionHandle~listener} listener - The callback function that
+     *   will be invoked when the event occurs.
+     * @return {string} - A token to pass to {@link SelectionHandle#off} to cancel
+     *   this subscription.
+     */
+
+  }, {
+    key: "on",
+    value: function on(eventType, listener) {
+      return this._emitter.on(eventType, listener);
+    }
+
+    /**
+     * Cancels event subscriptions created by {@link SelectionHandle#on}.
+     *
+     * @param {string} eventType - The type of event to unsubscribe.
+     * @param {string|SelectionHandle~listener} listener - Either the callback
+     *   function previously passed into {@link SelectionHandle#on}, or the
+     *   string that was returned from {@link SelectionHandle#on}.
+     */
+
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      return this._emitter.off(eventType, listener);
+    }
+
+    /**
+     * Shuts down the `SelectionHandle` object.
+     *
+     * Removes all event listeners that were added through this handle.
+     */
+
+  }, {
+    key: "close",
+    value: function close() {
+      this._emitter.removeAllListeners();
+      this.setGroup(null);
+    }
+  }, {
+    key: "value",
+    get: function get() {
+      return this._var ? this._var.get() : null;
+    }
+  }]);
+
+  return SelectionHandle;
+}();
+
+/**
+ * @callback SelectionHandle~listener
+ * @param {Object} event - An object containing details of the event. For
+ *   `"change"` events, this includes the properties `value` (the new
+ *   value of the selection, or `undefined` if no selection is active),
+ *   `oldValue` (the previous value of the selection), and `sender` (the
+ *   `SelectionHandle` instance that made the change).
+ */
+
+/**
+ * @event SelectionHandle#change
+ * @type {object}
+ * @property {object} value - The new value of the selection, or `undefined`
+ *   if no selection is active.
+ * @property {object} oldValue - The previous value of the selection.
+ * @property {SelectionHandle} sender - The `SelectionHandle` instance that
+ *   changed the value.
+ */
+
+},{"./events":1,"./group":4,"./util":11}],11:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _typeof = typeof Symbol === "function" && typeof Symbol.iterator === "symbol" ? function (obj) { return typeof obj; } : function (obj) { return obj && typeof Symbol === "function" && obj.constructor === Symbol && obj !== Symbol.prototype ? "symbol" : typeof obj; };
+
+exports.extend = extend;
+exports.checkSorted = checkSorted;
+exports.diffSortedLists = diffSortedLists;
+exports.dataframeToD3 = dataframeToD3;
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+function extend(target) {
+  for (var _len = arguments.length, sources = Array(_len > 1 ? _len - 1 : 0), _key = 1; _key < _len; _key++) {
+    sources[_key - 1] = arguments[_key];
+  }
+
+  for (var i = 0; i < sources.length; i++) {
+    var src = sources[i];
+    if (typeof src === "undefined" || src === null) continue;
+
+    for (var key in src) {
+      if (src.hasOwnProperty(key)) {
+        target[key] = src[key];
+      }
+    }
+  }
+  return target;
+}
+
+function checkSorted(list) {
+  for (var i = 1; i < list.length; i++) {
+    if (list[i] <= list[i - 1]) {
+      throw new Error("List is not sorted or contains duplicate");
+    }
+  }
+}
+
+function diffSortedLists(a, b) {
+  var i_a = 0;
+  var i_b = 0;
+
+  if (!a) a = [];
+  if (!b) b = [];
+
+  var a_only = [];
+  var b_only = [];
+
+  checkSorted(a);
+  checkSorted(b);
+
+  while (i_a < a.length && i_b < b.length) {
+    if (a[i_a] === b[i_b]) {
+      i_a++;
+      i_b++;
+    } else if (a[i_a] < b[i_b]) {
+      a_only.push(a[i_a++]);
+    } else {
+      b_only.push(b[i_b++]);
+    }
+  }
+
+  if (i_a < a.length) a_only = a_only.concat(a.slice(i_a));
+  if (i_b < b.length) b_only = b_only.concat(b.slice(i_b));
+  return {
+    removed: a_only,
+    added: b_only
+  };
+}
+
+// Convert from wide: { colA: [1,2,3], colB: [4,5,6], ... }
+// to long: [ {colA: 1, colB: 4}, {colA: 2, colB: 5}, ... ]
+function dataframeToD3(df) {
+  var names = [];
+  var length = void 0;
+  for (var name in df) {
+    if (df.hasOwnProperty(name)) names.push(name);
+    if (_typeof(df[name]) !== "object" || typeof df[name].length === "undefined") {
+      throw new Error("All fields must be arrays");
+    } else if (typeof length !== "undefined" && length !== df[name].length) {
+      throw new Error("All fields must be arrays of the same length");
+    }
+    length = df[name].length;
+  }
+  var results = [];
+  var item = void 0;
+  for (var row = 0; row < length; row++) {
+    item = {};
+    for (var col = 0; col < names.length; col++) {
+      item[names[col]] = df[names[col]][row];
+    }
+    results.push(item);
+  }
+  return results;
+}
+
+/**
+ * Keeps track of all event listener additions/removals and lets all active
+ * listeners be removed with a single operation.
+ *
+ * @private
+ */
+
+var SubscriptionTracker = exports.SubscriptionTracker = function () {
+  function SubscriptionTracker(emitter) {
+    _classCallCheck(this, SubscriptionTracker);
+
+    this._emitter = emitter;
+    this._subs = {};
+  }
+
+  _createClass(SubscriptionTracker, [{
+    key: "on",
+    value: function on(eventType, listener) {
+      var sub = this._emitter.on(eventType, listener);
+      this._subs[sub] = eventType;
+      return sub;
+    }
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      var sub = this._emitter.off(eventType, listener);
+      if (sub) {
+        delete this._subs[sub];
+      }
+      return sub;
+    }
+  }, {
+    key: "removeAllListeners",
+    value: function removeAllListeners() {
+      var _this = this;
+
+      var current_subs = this._subs;
+      this._subs = {};
+      Object.keys(current_subs).forEach(function (sub) {
+        _this._emitter.off(current_subs[sub], sub);
+      });
+    }
+  }]);
+
+  return SubscriptionTracker;
+}();
+
+},{}],12:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _typeof = typeof Symbol === "function" && typeof Symbol.iterator === "symbol" ? function (obj) { return typeof obj; } : function (obj) { return obj && typeof Symbol === "function" && obj.constructor === Symbol && obj !== Symbol.prototype ? "symbol" : typeof obj; };
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _events = require("./events");
+
+var _events2 = _interopRequireDefault(_events);
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+var Var = function () {
+  function Var(group, name, /*optional*/value) {
+    _classCallCheck(this, Var);
+
+    this._group = group;
+    this._name = name;
+    this._value = value;
+    this._events = new _events2.default();
+  }
+
+  _createClass(Var, [{
+    key: "get",
+    value: function get() {
+      return this._value;
+    }
+  }, {
+    key: "set",
+    value: function set(value, /*optional*/event) {
+      if (this._value === value) {
+        // Do nothing; the value hasn't changed
+        return;
+      }
+      var oldValue = this._value;
+      this._value = value;
+      // Alert JavaScript listeners that the value has changed
+      var evt = {};
+      if (event && (typeof event === "undefined" ? "undefined" : _typeof(event)) === "object") {
+        for (var k in event) {
+          if (event.hasOwnProperty(k)) evt[k] = event[k];
+        }
+      }
+      evt.oldValue = oldValue;
+      evt.value = value;
+      this._events.trigger("change", evt, this);
+
+      // TODO: Make this extensible, to let arbitrary back-ends know that
+      // something has changed
+      if (global.Shiny && global.Shiny.onInputChange) {
+        global.Shiny.onInputChange(".clientValue-" + (this._group.name !== null ? this._group.name + "-" : "") + this._name, typeof value === "undefined" ? null : value);
+      }
+    }
+  }, {
+    key: "on",
+    value: function on(eventType, listener) {
+      return this._events.on(eventType, listener);
+    }
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      return this._events.off(eventType, listener);
+    }
+  }]);
+
+  return Var;
+}();
+
+exports.default = Var;
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./events":1}]},{},[5])
+//# sourceMappingURL=crosstalk.js.map
diff --git a/docs/articles/S2_EDA_files/crosstalk-1.2.1/js/crosstalk.js.map b/docs/articles/S2_EDA_files/crosstalk-1.2.1/js/crosstalk.js.map
new file mode 100644
index 0000000..cff94f0
--- /dev/null
+++ b/docs/articles/S2_EDA_files/crosstalk-1.2.1/js/crosstalk.js.map
@@ -0,0 +1,37 @@
+{
+  "version": 3,
+  "sources": [
+    "node_modules/browser-pack/_prelude.js",
+    "javascript/src/events.js",
+    "javascript/src/filter.js",
+    "javascript/src/filterset.js",
+    "javascript/src/group.js",
+    "javascript/src/index.js",
+    "javascript/src/input.js",
+    "javascript/src/input_checkboxgroup.js",
+    "javascript/src/input_selectize.js",
+    "javascript/src/input_slider.js",
+    "javascript/src/selection.js",
+    "javascript/src/util.js",
+    "javascript/src/var.js"
+  ],
+  "names": [],
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+  "file": "generated.js",
+  "sourceRoot": "",
+  "sourcesContent": [
+    "(function(){function e(t,n,r){function s(o,u){if(!n[o]){if(!t[o]){var a=typeof require==\"function\"&&require;if(!u&&a)return a(o,!0);if(i)return i(o,!0);var f=new Error(\"Cannot find module '\"+o+\"'\");throw f.code=\"MODULE_NOT_FOUND\",f}var l=n[o]={exports:{}};t[o][0].call(l.exports,function(e){var n=t[o][1][e];return s(n?n:e)},l,l.exports,e,t,n,r)}return n[o].exports}var i=typeof require==\"function\"&&require;for(var o=0;o<r.length;o++)s(r[o]);return s}return e})()",
+    "export default class Events {\n  constructor() {\n    this._types = {};\n    this._seq = 0;\n  }\n\n  on(eventType, listener) {\n    let subs = this._types[eventType];\n    if (!subs) {\n      subs = this._types[eventType] = {};\n    }\n    let sub = \"sub\" + (this._seq++);\n    subs[sub] = listener;\n    return sub;\n  }\n\n  // Returns false if no match, or string for sub name if matched\n  off(eventType, listener) {\n    let subs = this._types[eventType];\n    if (typeof(listener) === \"function\") {\n      for (let key in subs) {\n        if (subs.hasOwnProperty(key)) {\n          if (subs[key] === listener) {\n            delete subs[key];\n            return key;\n          }\n        }\n      }\n      return false;\n    } else if (typeof(listener) === \"string\") {\n      if (subs && subs[listener]) {\n        delete subs[listener];\n        return listener;\n      }\n      return false;\n    } else {\n      throw new Error(\"Unexpected type for listener\");\n    }\n  }\n\n  trigger(eventType, arg, thisObj) {\n    let subs = this._types[eventType];\n    for (let key in subs) {\n      if (subs.hasOwnProperty(key)) {\n        subs[key].call(thisObj, arg);\n      }\n    }\n  }\n}\n",
+    "import Events from \"./events\";\nimport FilterSet from \"./filterset\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\nfunction getFilterSet(group) {\n  let fsVar = group.var(\"filterset\");\n  let result = fsVar.get();\n  if (!result) {\n    result = new FilterSet();\n    fsVar.set(result);\n  }\n  return result;\n}\n\nlet id = 1;\nfunction nextId() {\n  return id++;\n}\n\n/**\n * Use this class to contribute to, and listen for changes to, the filter set\n * for the given group of widgets. Filter input controls should create one\n * `FilterHandle` and only call {@link FilterHandle#set}. Output widgets that\n * wish to displayed filtered data should create one `FilterHandle` and use\n * the {@link FilterHandle#filteredKeys} property and listen for change\n * events.\n *\n * If two (or more) `FilterHandle` instances in the same webpage share the\n * same group name, they will contribute to a single \"filter set\". Each\n * `FilterHandle` starts out with a `null` value, which means they take\n * nothing away from the set of data that should be shown. To make a\n * `FilterHandle` actually remove data from the filter set, set its value to\n * an array of keys which should be displayed. Crosstalk will aggregate the\n * various key arrays by finding their intersection; only keys that are\n * present in all non-null filter handles are considered part of the filter\n * set.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the {@link FilterHandle#setGroup} method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class FilterHandle {\n  constructor(group, extraInfo) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The filterSet that we're tracking, if any. Can change over time.\n    this._filterSet = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._filterVar = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this._id = \"filter\" + nextId();\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this FilterHandle. If `set()` was\n   * previously called on this handle, switching groups will clear those keys\n   * from the old group's filter set. These keys will not be applied to the new\n   * group's filter set either. In other words, `setGroup()` effectively calls\n   * `clear()` before switching groups.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._filterVar) {\n      this._filterVar.off(\"change\", this._varOnChangeSub);\n      this.clear();\n      this._varOnChangeSub = null;\n      this._filterVar = null;\n      this._filterSet = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      group = grp(group);\n      this._filterSet = getFilterSet(group);\n      this._filterVar = grp(group).var(\"filter\");\n      let sub = this._filterVar.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Combine the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Close the handle. This clears this handle's contribution to the filter set,\n   * and unsubscribes all event listeners.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.clear();\n    this.setGroup(null);\n  }\n\n  /**\n   * Clear this handle's contribution to the filter set.\n   *\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  clear(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.clear(this._id);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * Set this handle's contribution to the filter set. This array should consist\n   * of the keys of the rows that _should_ be displayed; any keys that are not\n   * present in the array will be considered _filtered out_. Note that multiple\n   * `FilterHandle` instances in the group may each contribute an array of keys,\n   * and only those keys that appear in _all_ of the arrays make it through the\n   * filter.\n   *\n   * @param {string[]} keys - Empty array, or array of keys. To clear the\n   *   filter, don't pass an empty array; instead, use the\n   *   {@link FilterHandle#clear} method.\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  set(keys, extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.update(this._id, keys);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * @return {string[]|null} - Either: 1) an array of keys that made it through\n   *   all of the `FilterHandle` instances, or, 2) `null`, which means no filter\n   *   is being applied (all data should be displayed).\n   */\n  get filteredKeys() {\n    return this._filterSet ? this._filterSet.value : null;\n  }\n\n  /**\n   * Subscribe to events on this `FilterHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {FilterHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link FilterHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancel event subscriptions created by {@link FilterHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|FilterHandle~listener} listener - Either the callback\n   *   function previously passed into {@link FilterHandle#on}, or the\n   *   string that was returned from {@link FilterHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  _onChange(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterVar.set(this._filterSet.value, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * @callback FilterHandle~listener\n   * @param {Object} event - An object containing details of the event. For\n   *   `\"change\"` events, this includes the properties `value` (the new\n   *   value of the filter set, or `null` if no filter set is active),\n   *   `oldValue` (the previous value of the filter set), and `sender` (the\n   *   `FilterHandle` instance that made the change).\n   */\n\n}\n\n/**\n * @event FilterHandle#change\n * @type {object}\n * @property {object} value - The new value of the filter set, or `null`\n *   if no filter set is active.\n * @property {object} oldValue - The previous value of the filter set.\n * @property {FilterHandle} sender - The `FilterHandle` instance that\n *   changed the value.\n */\n",
+    "import { diffSortedLists } from \"./util\";\n\nfunction naturalComparator(a, b) {\n  if (a === b) {\n    return 0;\n  } else if (a < b) {\n    return -1;\n  } else if (a > b) {\n    return 1;\n  }\n}\n\n/**\n * @private\n */\nexport default class FilterSet {\n  constructor() {\n    this.reset();\n  }\n\n  reset() {\n    // Key: handle ID, Value: array of selected keys, or null\n    this._handles = {};\n    // Key: key string, Value: count of handles that include it\n    this._keys = {};\n    this._value = null;\n    this._activeHandles = 0;\n  }\n\n  get value() {\n    return this._value;\n  }\n\n  update(handleId, keys) {\n    if (keys !== null) {\n      keys = keys.slice(0); // clone before sorting\n      keys.sort(naturalComparator);\n    }\n\n    let {added, removed} = diffSortedLists(this._handles[handleId], keys);\n    this._handles[handleId] = keys;\n\n    for (let i = 0; i < added.length; i++) {\n      this._keys[added[i]] = (this._keys[added[i]] || 0) + 1;\n    }\n    for (let i = 0; i < removed.length; i++) {\n      this._keys[removed[i]]--;\n    }\n\n    this._updateValue(keys);\n  }\n\n  /**\n   * @param {string[]} keys Sorted array of strings that indicate\n   * a superset of possible keys.\n   * @private\n   */\n  _updateValue(keys = this._allKeys) {\n    let handleCount = Object.keys(this._handles).length;\n    if (handleCount === 0) {\n      this._value = null;\n    } else {\n      this._value = [];\n      for (let i = 0; i < keys.length; i++) {\n        let count = this._keys[keys[i]];\n        if (count === handleCount) {\n          this._value.push(keys[i]);\n        }\n      }\n    }\n  }\n\n  clear(handleId) {\n    if (typeof(this._handles[handleId]) === \"undefined\") {\n      return;\n    }\n\n    let keys = this._handles[handleId];\n    if (!keys) {\n      keys = [];\n    }\n\n    for (let i = 0; i < keys.length; i++) {\n      this._keys[keys[i]]--;\n    }\n    delete this._handles[handleId];\n\n    this._updateValue();\n  }\n\n  get _allKeys() {\n    let allKeys = Object.keys(this._keys);\n    allKeys.sort(naturalComparator);\n    return allKeys;\n  }\n}\n",
+    "import Var from \"./var\";\n\n// Use a global so that multiple copies of crosstalk.js can be loaded and still\n// have groups behave as singletons across all copies.\nglobal.__crosstalk_groups = global.__crosstalk_groups || {};\nlet groups = global.__crosstalk_groups;\n\nexport default function group(groupName) {\n  if (groupName && typeof(groupName) === \"string\") {\n    if (!groups.hasOwnProperty(groupName)) {\n      groups[groupName] = new Group(groupName);\n    }\n    return groups[groupName];\n  } else if (typeof(groupName) === \"object\" && groupName._vars && groupName.var) {\n    // Appears to already be a group object\n    return groupName;\n  } else if (Array.isArray(groupName) &&\n      groupName.length == 1 &&\n      typeof(groupName[0]) === \"string\") {\n    return group(groupName[0]);\n  } else {\n    throw new Error(\"Invalid groupName argument\");\n  }\n}\n\nclass Group {\n  constructor(name) {\n    this.name = name;\n    this._vars = {};\n  }\n\n  var(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    if (!this._vars.hasOwnProperty(name))\n      this._vars[name] = new Var(this, name);\n    return this._vars[name];\n  }\n\n  has(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    return this._vars.hasOwnProperty(name);\n  }\n}\n",
+    "import group from \"./group\";\nimport { SelectionHandle } from \"./selection\";\nimport { FilterHandle } from \"./filter\";\nimport { bind } from \"./input\";\nimport \"./input_selectize\";\nimport \"./input_checkboxgroup\";\nimport \"./input_slider\";\n\nconst defaultGroup = group(\"default\");\n\nfunction var_(name) {\n  return defaultGroup.var(name);\n}\n\nfunction has(name) {\n  return defaultGroup.has(name);\n}\n\nif (global.Shiny) {\n  global.Shiny.addCustomMessageHandler(\"update-client-value\", function(message) {\n    if (typeof(message.group) === \"string\") {\n      group(message.group).var(message.name).set(message.value);\n    } else {\n      var_(message.name).set(message.value);\n    }\n  });\n}\n\nconst crosstalk = {\n  group: group,\n  var: var_,\n  has: has,\n  SelectionHandle: SelectionHandle,\n  FilterHandle: FilterHandle,\n  bind: bind\n};\n\n/**\n * @namespace crosstalk\n */\nexport default crosstalk;\nglobal.crosstalk = crosstalk;\n",
+    "let $ = global.jQuery;\n\nlet bindings = {};\n\nexport function register(reg) {\n  bindings[reg.className] = reg;\n  if (global.document && global.document.readyState !== \"complete\") {\n    $(() => {\n      bind();\n    });\n  } else if (global.document) {\n    setTimeout(bind, 100);\n  }\n}\n\nexport function bind() {\n  Object.keys(bindings).forEach(function(className) {\n    let binding = bindings[className];\n    $(\".\" + binding.className).not(\".crosstalk-input-bound\").each(function(i, el) {\n      bindInstance(binding, el);\n    });\n  });\n}\n\n// Escape jQuery identifier\nfunction $escape(val) {\n  return val.replace(/([!\"#$%&'()*+,./:;<=>?@[\\\\\\]^`{|}~])/g, \"\\\\$1\");\n}\n\nfunction bindEl(el) {\n  let $el = $(el);\n  Object.keys(bindings).forEach(function(className) {\n    if ($el.hasClass(className) && !$el.hasClass(\"crosstalk-input-bound\")) {\n      let binding = bindings[className];\n      bindInstance(binding, el);\n    }\n  });\n}\n\nfunction bindInstance(binding, el) {\n  let jsonEl = $(el).find(\"script[type='application/json'][data-for='\" + $escape(el.id) + \"']\");\n  let data = JSON.parse(jsonEl[0].innerText);\n\n  let instance = binding.factory(el, data);\n  $(el).data(\"crosstalk-instance\", instance);\n  $(el).addClass(\"crosstalk-input-bound\");\n}\n\nif (global.Shiny) {\n  let inputBinding = new global.Shiny.InputBinding();\n  let $ = global.jQuery;\n  $.extend(inputBinding, {\n    find: function(scope) {\n      return $(scope).find(\".crosstalk-input\");\n    },\n    initialize: function(el) {\n      if (!$(el).hasClass(\"crosstalk-input-bound\")) {\n        bindEl(el);\n      }\n    },\n    getId: function(el) {\n      return el.id;\n    },\n    getValue: function(el) {\n\n    },\n    setValue: function(el, value) {\n\n    },\n    receiveMessage: function(el, data) {\n\n    },\n    subscribe: function(el, callback) {\n      $(el).data(\"crosstalk-instance\").resume();\n    },\n    unsubscribe: function(el) {\n      $(el).data(\"crosstalk-instance\").suspend();\n    }\n  });\n  global.Shiny.inputBindings.register(inputBinding, \"crosstalk.inputBinding\");\n}\n",
+    "import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-checkboxgroup\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    let $el = $(el);\n    $el.on(\"change\", \"input[type='checkbox']\", function() {\n      let checked = $el.find(\"input[type='checkbox']:checked\");\n      if (checked.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        checked.each(function() {\n          data.map[this.value].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n",
+    "import * as input from \"./input\";\nimport * as util from \"./util\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-select\",\n\n  factory: function(el, data) {\n    /*\n     * items: {value: [...], label: [...]}\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n\n    let first = [{value: \"\", label: \"(All)\"}];\n    let items = util.dataframeToD3(data.items);\n    let opts = {\n      options: first.concat(items),\n      valueField: \"value\",\n      labelField: \"label\",\n      searchField: \"label\"\n    };\n\n    let select = $(el).find(\"select\")[0];\n\n    let selectize = $(select).selectize(opts)[0].selectize;\n\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    selectize.on(\"change\", function() {\n      if (selectize.items.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        selectize.items.forEach(function(group) {\n          data.map[group].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n",
+    "import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\nlet strftime = global.strftime;\n\ninput.register({\n  className: \"crosstalk-input-slider\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let opts = {};\n    let $el = $(el).find(\"input\");\n    let dataType = $el.data(\"data-type\");\n    let timeFormat = $el.data(\"time-format\");\n    let round = $el.data(\"round\");\n    let timeFormatter;\n\n    // Set up formatting functions\n    if (dataType === \"date\") {\n      timeFormatter = strftime.utc();\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n\n    } else if (dataType === \"datetime\") {\n      let timezone = $el.data(\"timezone\");\n      if (timezone)\n        timeFormatter = strftime.timezone(timezone);\n      else\n        timeFormatter = strftime;\n\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n    } else if (dataType === \"number\") {\n      if (typeof round !== \"undefined\")\n        opts.prettify = function(num) {\n          let factor = Math.pow(10, round);\n          return Math.round(num * factor) / factor;\n        };\n    }\n\n    $el.ionRangeSlider(opts);\n\n    function getValue() {\n      let result = $el.data(\"ionRangeSlider\").result;\n\n      // Function for converting numeric value from slider to appropriate type.\n      let convert;\n      let dataType = $el.data(\"data-type\");\n      if (dataType === \"date\") {\n        convert = function(val) {\n          return formatDateUTC(new Date(+val));\n        };\n      } else if (dataType === \"datetime\") {\n        convert = function(val) {\n          // Convert ms to s\n          return +val / 1000;\n        };\n      } else {\n        convert = function(val) { return +val; };\n      }\n\n      if ($el.data(\"ionRangeSlider\").options.type === \"double\") {\n        return [convert(result.from), convert(result.to)];\n      } else {\n        return convert(result.from);\n      }\n    }\n\n    let lastKnownKeys = null;\n\n    $el.on(\"change.crosstalkSliderInput\", function(event) {\n      if (!$el.data(\"updating\") && !$el.data(\"animating\")) {\n        let [from, to] = getValue();\n        let keys = [];\n        for (let i = 0; i < data.values.length; i++) {\n          let val = data.values[i];\n          if (val >= from && val <= to) {\n            keys.push(data.keys[i]);\n          }\n        }\n        keys.sort();\n        ctHandle.set(keys);\n        lastKnownKeys = keys;\n      }\n    });\n\n\n    // let $el = $(el);\n    // $el.on(\"change\", \"input[type=\"checkbox\"]\", function() {\n    //   let checked = $el.find(\"input[type=\"checkbox\"]:checked\");\n    //   if (checked.length === 0) {\n    //     ctHandle.clear();\n    //   } else {\n    //     let keys = {};\n    //     checked.each(function() {\n    //       data.map[this.value].forEach(function(key) {\n    //         keys[key] = true;\n    //       });\n    //     });\n    //     let keyArray = Object.keys(keys);\n    //     keyArray.sort();\n    //     ctHandle.set(keyArray);\n    //   }\n    // });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n\n\n// Convert a number to a string with leading zeros\nfunction padZeros(n, digits) {\n  let str = n.toString();\n  while (str.length < digits)\n    str = \"0\" + str;\n  return str;\n}\n\n// Given a Date object, return a string in yyyy-mm-dd format, using the\n// UTC date. This may be a day off from the date in the local time zone.\nfunction formatDateUTC(date) {\n  if (date instanceof Date) {\n    return date.getUTCFullYear() + \"-\" +\n           padZeros(date.getUTCMonth()+1, 2) + \"-\" +\n           padZeros(date.getUTCDate(), 2);\n\n  } else {\n    return null;\n  }\n}\n",
+    "import Events from \"./events\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\n/**\n * Use this class to read and write (and listen for changes to) the selection\n * for a Crosstalk group. This is intended to be used for linked brushing.\n *\n * If two (or more) `SelectionHandle` instances in the same webpage share the\n * same group name, they will share the same state. Setting the selection using\n * one `SelectionHandle` instance will result in the `value` property instantly\n * changing across the others, and `\"change\"` event listeners on all instances\n * (including the one that initiated the sending) will fire.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the [SelectionHandle#setGroup](#setGroup) method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class SelectionHandle {\n\n  constructor(group = null, extraInfo = null) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._var = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this SelectionHandle. The group\n   * being switched away from (if any) will not have its selection value\n   * modified as a result of calling `setGroup`, even if this handle was the\n   * most recent handle to set the selection of the group.\n   *\n   * The group being switched to (if any) will also not have its selection value\n   * modified as a result of calling `setGroup`. If you want to set the\n   * selection value of the new group, call `set` explicitly.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._var) {\n      this._var.off(\"change\", this._varOnChangeSub);\n      this._var = null;\n      this._varOnChangeSub = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      this._var = grp(group).var(\"selection\");\n      let sub = this._var.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Retrieves the current selection for the group represented by this\n   * `SelectionHandle`.\n   *\n   * - If no selection is active, then this value will be falsy.\n   * - If a selection is active, but no data points are selected, then this\n   *   value will be an empty array.\n   * - If a selection is active, and data points are selected, then the keys\n   *   of the selected data points will be present in the array.\n   */\n  get value() {\n    return this._var ? this._var.get() : null;\n  }\n\n  /**\n   * Combines the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    // Important incidental effect: shallow clone is returned\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {string[]} selectedKeys - Falsy, empty array, or array of keys (see\n   *   {@link SelectionHandle#value}).\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `SelectionHandle` constructor).\n   */\n  set(selectedKeys, extraInfo) {\n    if (this._var)\n      this._var.set(selectedKeys, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any that were passed\n   *   into the `SelectionHandle` constructor).\n   */\n  clear(extraInfo) {\n    if (this._var)\n      this.set(void 0, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Subscribes to events on this `SelectionHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {SelectionHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link SelectionHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancels event subscriptions created by {@link SelectionHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|SelectionHandle~listener} listener - Either the callback\n   *   function previously passed into {@link SelectionHandle#on}, or the\n   *   string that was returned from {@link SelectionHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  /**\n   * Shuts down the `SelectionHandle` object.\n   *\n   * Removes all event listeners that were added through this handle.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.setGroup(null);\n  }\n}\n\n/**\n * @callback SelectionHandle~listener\n * @param {Object} event - An object containing details of the event. For\n *   `\"change\"` events, this includes the properties `value` (the new\n *   value of the selection, or `undefined` if no selection is active),\n *   `oldValue` (the previous value of the selection), and `sender` (the\n *   `SelectionHandle` instance that made the change).\n */\n\n/**\n * @event SelectionHandle#change\n * @type {object}\n * @property {object} value - The new value of the selection, or `undefined`\n *   if no selection is active.\n * @property {object} oldValue - The previous value of the selection.\n * @property {SelectionHandle} sender - The `SelectionHandle` instance that\n *   changed the value.\n */\n",
+    "export function extend(target, ...sources) {\n  for (let i = 0; i < sources.length; i++) {\n    let src = sources[i];\n    if (typeof(src) === \"undefined\" || src === null)\n      continue;\n\n    for (let key in src) {\n      if (src.hasOwnProperty(key)) {\n        target[key] = src[key];\n      }\n    }\n  }\n  return target;\n}\n\nexport function checkSorted(list) {\n  for (let i = 1; i < list.length; i++) {\n    if (list[i] <= list[i-1]) {\n      throw new Error(\"List is not sorted or contains duplicate\");\n    }\n  }\n}\n\nexport function diffSortedLists(a, b) {\n  let i_a = 0;\n  let i_b = 0;\n\n  if (!a) a = [];\n  if (!b) b = [];\n\n  let a_only = [];\n  let b_only = [];\n\n  checkSorted(a);\n  checkSorted(b);\n\n  while (i_a < a.length && i_b < b.length) {\n    if (a[i_a] === b[i_b]) {\n      i_a++;\n      i_b++;\n    } else if (a[i_a] < b[i_b]) {\n      a_only.push(a[i_a++]);\n    } else {\n      b_only.push(b[i_b++]);\n    }\n  }\n\n  if (i_a < a.length)\n    a_only = a_only.concat(a.slice(i_a));\n  if (i_b < b.length)\n    b_only = b_only.concat(b.slice(i_b));\n  return {\n    removed: a_only,\n    added: b_only\n  };\n}\n\n// Convert from wide: { colA: [1,2,3], colB: [4,5,6], ... }\n// to long: [ {colA: 1, colB: 4}, {colA: 2, colB: 5}, ... ]\nexport function dataframeToD3(df) {\n  let names = [];\n  let length;\n  for (let name in df) {\n    if (df.hasOwnProperty(name))\n      names.push(name);\n    if (typeof(df[name]) !== \"object\" || typeof(df[name].length) === \"undefined\") {\n      throw new Error(\"All fields must be arrays\");\n    } else if (typeof(length) !== \"undefined\" && length !== df[name].length) {\n      throw new Error(\"All fields must be arrays of the same length\");\n    }\n    length = df[name].length;\n  }\n  let results = [];\n  let item;\n  for (let row = 0; row < length; row++) {\n    item = {};\n    for (let col = 0; col < names.length; col++) {\n      item[names[col]] = df[names[col]][row];\n    }\n    results.push(item);\n  }\n  return results;\n}\n\n/**\n * Keeps track of all event listener additions/removals and lets all active\n * listeners be removed with a single operation.\n *\n * @private\n */\nexport class SubscriptionTracker {\n  constructor(emitter) {\n    this._emitter = emitter;\n    this._subs = {};\n  }\n\n  on(eventType, listener) {\n    let sub = this._emitter.on(eventType, listener);\n    this._subs[sub] = eventType;\n    return sub;\n  }\n\n  off(eventType, listener) {\n    let sub = this._emitter.off(eventType, listener);\n    if (sub) {\n      delete this._subs[sub];\n    }\n    return sub;\n  }\n\n  removeAllListeners() {\n    let current_subs = this._subs;\n    this._subs = {};\n    Object.keys(current_subs).forEach((sub) => {\n      this._emitter.off(current_subs[sub], sub);\n    });\n  }\n}\n",
+    "import Events from \"./events\";\n\nexport default class Var {\n  constructor(group, name, /*optional*/ value) {\n    this._group = group;\n    this._name = name;\n    this._value = value;\n    this._events = new Events();\n  }\n\n  get() {\n    return this._value;\n  }\n\n  set(value, /*optional*/ event) {\n    if (this._value === value) {\n      // Do nothing; the value hasn't changed\n      return;\n    }\n    let oldValue = this._value;\n    this._value = value;\n    // Alert JavaScript listeners that the value has changed\n    let evt = {};\n    if (event && typeof(event) === \"object\") {\n      for (let k in event) {\n        if (event.hasOwnProperty(k))\n          evt[k] = event[k];\n      }\n    }\n    evt.oldValue = oldValue;\n    evt.value = value;\n    this._events.trigger(\"change\", evt, this);\n\n    // TODO: Make this extensible, to let arbitrary back-ends know that\n    // something has changed\n    if (global.Shiny && global.Shiny.onInputChange) {\n      global.Shiny.onInputChange(\n        \".clientValue-\" +\n          (this._group.name !== null ? this._group.name + \"-\" : \"\") +\n          this._name,\n        typeof(value) === \"undefined\" ? null : value\n      );\n    }\n  }\n\n  on(eventType, listener) {\n    return this._events.on(eventType, listener);\n  }\n\n  off(eventType, listener) {\n    return this._events.off(eventType, listener);\n  }\n}\n"
+  ]
+}
\ No newline at end of file
diff --git a/docs/articles/S2_EDA_files/crosstalk-1.2.1/js/crosstalk.min.js b/docs/articles/S2_EDA_files/crosstalk-1.2.1/js/crosstalk.min.js
new file mode 100644
index 0000000..b7ec0ac
--- /dev/null
+++ b/docs/articles/S2_EDA_files/crosstalk-1.2.1/js/crosstalk.min.js
@@ -0,0 +1,2 @@
+!function o(u,a,l){function s(n,e){if(!a[n]){if(!u[n]){var t="function"==typeof require&&require;if(!e&&t)return t(n,!0);if(f)return f(n,!0);var r=new Error("Cannot find module '"+n+"'");throw r.code="MODULE_NOT_FOUND",r}var i=a[n]={exports:{}};u[n][0].call(i.exports,function(e){var t=u[n][1][e];return s(t||e)},i,i.exports,o,u,a,l)}return a[n].exports}for(var f="function"==typeof require&&require,e=0;e<l.length;e++)s(l[e]);return s}({1:[function(e,t,n){"use strict";Object.defineProperty(n,"__esModule",{value:!0});var r=function(){function r(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(e,t,n){return t&&r(e.prototype,t),n&&r(e,n),e}}();var i=function(){function e(){!function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}(this,e),this._types={},this._seq=0}return r(e,[{key:"on",value:function(e,t){var n=this._types[e];n||(n=this._types[e]={});var r="sub"+this._seq++;return n[r]=t,r}},{key:"off",value:function(e,t){var n=this._types[e];if("function"==typeof t){for(var r in n)if(n.hasOwnProperty(r)&&n[r]===t)return delete n[r],r;return!1}if("string"==typeof t)return!(!n||!n[t])&&(delete n[t],t);throw new Error("Unexpected type for listener")}},{key:"trigger",value:function(e,t,n){var r=this._types[e];for(var i in r)r.hasOwnProperty(i)&&r[i].call(n,t)}}]),e}();n.default=i},{}],2:[function(e,t,n){"use strict";Object.defineProperty(n,"__esModule",{value:!0}),n.FilterHandle=void 0;var r=function(){function r(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(e,t,n){return t&&r(e.prototype,t),n&&r(e,n),e}}(),i=l(e("./events")),o=l(e("./filterset")),u=l(e("./group")),a=function(e){{if(e&&e.__esModule)return e;var t={};if(null!=e)for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&(t[n]=e[n]);return t.default=e,t}}(e("./util"));function l(e){return e&&e.__esModule?e:{default:e}}var s=1;n.FilterHandle=function(){function n(e,t){!function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}(this,n),this._eventRelay=new i.default,this._emitter=new a.SubscriptionTracker(this._eventRelay),this._group=null,this._filterSet=null,this._filterVar=null,this._varOnChangeSub=null,this._extraInfo=a.extend({sender:this},t),this._id="filter"+s++,this.setGroup(e)}return r(n,[{key:"setGroup",value:function(e){var t,n,r=this;if(this._group!==e&&((this._group||e)&&(this._filterVar&&(this._filterVar.off("change",this._varOnChangeSub),this.clear(),this._varOnChangeSub=null,this._filterVar=null,this._filterSet=null),this._group=e))){e=(0,u.default)(e),this._filterSet=(t=e.var("filterset"),(n=t.get())||(n=new o.default,t.set(n)),n),this._filterVar=(0,u.default)(e).var("filter");var i=this._filterVar.on("change",function(e){r._eventRelay.trigger("change",e,r)});this._varOnChangeSub=i}}},{key:"_mergeExtraInfo",value:function(e){return a.extend({},this._extraInfo?this._extraInfo:null,e||null)}},{key:"close",value:function(){this._emitter.removeAllListeners(),this.clear(),this.setGroup(null)}},{key:"clear",value:function(e){this._filterSet&&(this._filterSet.clear(this._id),this._onChange(e))}},{key:"set",value:function(e,t){this._filterSet&&(this._filterSet.update(this._id,e),this._onChange(t))}},{key:"on",value:function(e,t){return this._emitter.on(e,t)}},{key:"off",value:function(e,t){return this._emitter.off(e,t)}},{key:"_onChange",value:function(e){this._filterSet&&this._filterVar.set(this._filterSet.value,this._mergeExtraInfo(e))}},{key:"filteredKeys",get:function(){return this._filterSet?this._filterSet.value:null}}]),n}()},{"./events":1,"./filterset":3,"./group":4,"./util":11}],3:[function(e,t,n){"use strict";Object.defineProperty(n,"__esModule",{value:!0});var r=function(){function r(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(e,t,n){return t&&r(e.prototype,t),n&&r(e,n),e}}(),a=e("./util");function l(e,t){return e===t?0:e<t?-1:t<e?1:void 0}var i=function(){function e(){!function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}(this,e),this.reset()}return r(e,[{key:"reset",value:function(){this._handles={},this._keys={},this._value=null,this._activeHandles=0}},{key:"update",value:function(e,t){null!==t&&(t=t.slice(0)).sort(l);var n=(0,a.diffSortedLists)(this._handles[e],t),r=n.added,i=n.removed;this._handles[e]=t;for(var o=0;o<r.length;o++)this._keys[r[o]]=(this._keys[r[o]]||0)+1;for(var u=0;u<i.length;u++)this._keys[i[u]]--;this._updateValue(t)}},{key:"_updateValue",value:function(){var e=0<arguments.length&&void 0!==arguments[0]?arguments[0]:this._allKeys,t=Object.keys(this._handles).length;if(0===t)this._value=null;else{this._value=[];for(var n=0;n<e.length;n++){this._keys[e[n]]===t&&this._value.push(e[n])}}}},{key:"clear",value:function(e){if(void 0!==this._handles[e]){var t=this._handles[e];t||(t=[]);for(var n=0;n<t.length;n++)this._keys[t[n]]--;delete this._handles[e],this._updateValue()}}},{key:"value",get:function(){return this._value}},{key:"_allKeys",get:function(){var e=Object.keys(this._keys);return e.sort(l),e}}]),e}();n.default=i},{"./util":11}],4:[function(l,e,s){(function(e){"use strict";Object.defineProperty(s,"__esModule",{value:!0});var n=function(){function r(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(e,t,n){return t&&r(e.prototype,t),n&&r(e,n),e}}(),r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e};s.default=function e(t){{if(t&&"string"==typeof t)return u.hasOwnProperty(t)||(u[t]=new a(t)),u[t];if("object"===(void 0===t?"undefined":r(t))&&t._vars&&t.var)return t;if(Array.isArray(t)&&1==t.length&&"string"==typeof t[0])return e(t[0]);throw new Error("Invalid groupName argument")}};var t,i=l("./var"),o=(t=i)&&t.__esModule?t:{default:t};e.__crosstalk_groups=e.__crosstalk_groups||{};var u=e.__crosstalk_groups;var a=function(){function t(e){!function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}(this,t),this.name=e,this._vars={}}return n(t,[{key:"var",value:function(e){if(!e||"string"!=typeof e)throw new Error("Invalid var name");return this._vars.hasOwnProperty(e)||(this._vars[e]=new o.default(this,e)),this._vars[e]}},{key:"has",value:function(e){if(!e||"string"!=typeof e)throw new Error("Invalid var name");return this._vars.hasOwnProperty(e)}}]),t}()}).call(this,"undefined"!=typeof global?global:"undefined"!=typeof self?self:"undefined"!=typeof window?window:{})},{"./var":12}],5:[function(f,e,c){(function(e){"use strict";Object.defineProperty(c,"__esModule",{value:!0});var t,n=f("./group"),r=(t=n)&&t.__esModule?t:{default:t},i=f("./selection"),o=f("./filter"),u=f("./input");f("./input_selectize"),f("./input_checkboxgroup"),f("./input_slider");var a=(0,r.default)("default");function l(e){return a.var(e)}e.Shiny&&e.Shiny.addCustomMessageHandler("update-client-value",function(e){"string"==typeof e.group?(0,r.default)(e.group).var(e.name).set(e.value):l(e.name).set(e.value)});var s={group:r.default,var:l,has:function(e){return a.has(e)},SelectionHandle:i.SelectionHandle,FilterHandle:o.FilterHandle,bind:u.bind};c.default=s,e.crosstalk=s}).call(this,"undefined"!=typeof global?global:"undefined"!=typeof self?self:"undefined"!=typeof window?window:{})},{"./filter":2,"./group":4,"./input":6,"./input_checkboxgroup":7,"./input_selectize":8,"./input_slider":9,"./selection":10}],6:[function(e,t,a){(function(t){"use strict";Object.defineProperty(a,"__esModule",{value:!0}),a.register=function(e){r[e.className]=e,t.document&&"complete"!==t.document.readyState?o(function(){n()}):t.document&&setTimeout(n,100)},a.bind=n;var o=t.jQuery,r={};function n(){Object.keys(r).forEach(function(e){var n=r[e];o("."+n.className).not(".crosstalk-input-bound").each(function(e,t){i(n,t)})})}function i(e,t){var n=o(t).find("script[type='application/json'][data-for='"+t.id.replace(/([!"#$%&'()*+,./:;<=>?@[\\\]^`{|}~])/g,"\\$1")+"']"),r=JSON.parse(n[0].innerText),i=e.factory(t,r);o(t).data("crosstalk-instance",i),o(t).addClass("crosstalk-input-bound")}if(t.Shiny){var e=new t.Shiny.InputBinding,u=t.jQuery;u.extend(e,{find:function(e){return u(e).find(".crosstalk-input")},initialize:function(e){var t,n;u(e).hasClass("crosstalk-input-bound")||(n=o(t=e),Object.keys(r).forEach(function(e){n.hasClass(e)&&!n.hasClass("crosstalk-input-bound")&&i(r[e],t)}))},getId:function(e){return e.id},getValue:function(e){},setValue:function(e,t){},receiveMessage:function(e,t){},subscribe:function(e,t){u(e).data("crosstalk-instance").resume()},unsubscribe:function(e){u(e).data("crosstalk-instance").suspend()}}),t.Shiny.inputBindings.register(e,"crosstalk.inputBinding")}}).call(this,"undefined"!=typeof global?global:"undefined"!=typeof self?self:"undefined"!=typeof window?window:{})},{}],7:[function(r,e,t){(function(e){"use strict";var t=function(e){{if(e&&e.__esModule)return e;var t={};if(null!=e)for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&(t[n]=e[n]);return t.default=e,t}}(r("./input")),n=r("./filter");var a=e.jQuery;t.register({className:"crosstalk-input-checkboxgroup",factory:function(e,r){var i=new n.FilterHandle(r.group),o=void 0,u=a(e);return 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e(t,n,r){function s(o,u){if(!n[o]){if(!t[o]){var a=typeof require==\"function\"&&require;if(!u&&a)return a(o,!0);if(i)return i(o,!0);var f=new Error(\"Cannot find module '\"+o+\"'\");throw f.code=\"MODULE_NOT_FOUND\",f}var l=n[o]={exports:{}};t[o][0].call(l.exports,function(e){var n=t[o][1][e];return s(n?n:e)},l,l.exports,e,t,n,r)}return n[o].exports}var i=typeof require==\"function\"&&require;for(var o=0;o<r.length;o++)s(r[o]);return s}return e})()","export default class Events {\n  constructor() {\n    this._types = {};\n    this._seq = 0;\n  }\n\n  on(eventType, listener) {\n    let subs = this._types[eventType];\n    if (!subs) {\n      subs = this._types[eventType] = {};\n    }\n    let sub = \"sub\" + (this._seq++);\n    subs[sub] = listener;\n    return sub;\n  }\n\n  // Returns false if no match, or string for sub name if matched\n  off(eventType, listener) {\n    let subs = this._types[eventType];\n    if (typeof(listener) === \"function\") {\n      for (let key in subs) {\n        if (subs.hasOwnProperty(key)) {\n          if (subs[key] === listener) {\n            delete subs[key];\n            return key;\n          }\n        }\n      }\n      return false;\n    } else if (typeof(listener) === \"string\") {\n      if (subs && subs[listener]) {\n        delete subs[listener];\n        return listener;\n      }\n      return false;\n    } else {\n      throw new Error(\"Unexpected type for listener\");\n    }\n  }\n\n  trigger(eventType, arg, thisObj) {\n    let subs = this._types[eventType];\n    for (let key in subs) {\n      if (subs.hasOwnProperty(key)) {\n        subs[key].call(thisObj, arg);\n      }\n    }\n  }\n}\n","import Events from \"./events\";\nimport FilterSet from \"./filterset\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\nfunction getFilterSet(group) {\n  let fsVar = group.var(\"filterset\");\n  let result = fsVar.get();\n  if (!result) {\n    result = new FilterSet();\n    fsVar.set(result);\n  }\n  return result;\n}\n\nlet id = 1;\nfunction nextId() {\n  return id++;\n}\n\n/**\n * Use this class to contribute to, and listen for changes to, the filter set\n * for the given group of widgets. Filter input controls should create one\n * `FilterHandle` and only call {@link FilterHandle#set}. Output widgets that\n * wish to displayed filtered data should create one `FilterHandle` and use\n * the {@link FilterHandle#filteredKeys} property and listen for change\n * events.\n *\n * If two (or more) `FilterHandle` instances in the same webpage share the\n * same group name, they will contribute to a single \"filter set\". Each\n * `FilterHandle` starts out with a `null` value, which means they take\n * nothing away from the set of data that should be shown. To make a\n * `FilterHandle` actually remove data from the filter set, set its value to\n * an array of keys which should be displayed. Crosstalk will aggregate the\n * various key arrays by finding their intersection; only keys that are\n * present in all non-null filter handles are considered part of the filter\n * set.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the {@link FilterHandle#setGroup} method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class FilterHandle {\n  constructor(group, extraInfo) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The filterSet that we're tracking, if any. Can change over time.\n    this._filterSet = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._filterVar = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this._id = \"filter\" + nextId();\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this FilterHandle. If `set()` was\n   * previously called on this handle, switching groups will clear those keys\n   * from the old group's filter set. These keys will not be applied to the new\n   * group's filter set either. In other words, `setGroup()` effectively calls\n   * `clear()` before switching groups.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._filterVar) {\n      this._filterVar.off(\"change\", this._varOnChangeSub);\n      this.clear();\n      this._varOnChangeSub = null;\n      this._filterVar = null;\n      this._filterSet = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      group = grp(group);\n      this._filterSet = getFilterSet(group);\n      this._filterVar = grp(group).var(\"filter\");\n      let sub = this._filterVar.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Combine the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Close the handle. This clears this handle's contribution to the filter set,\n   * and unsubscribes all event listeners.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.clear();\n    this.setGroup(null);\n  }\n\n  /**\n   * Clear this handle's contribution to the filter set.\n   *\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  clear(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.clear(this._id);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * Set this handle's contribution to the filter set. This array should consist\n   * of the keys of the rows that _should_ be displayed; any keys that are not\n   * present in the array will be considered _filtered out_. Note that multiple\n   * `FilterHandle` instances in the group may each contribute an array of keys,\n   * and only those keys that appear in _all_ of the arrays make it through the\n   * filter.\n   *\n   * @param {string[]} keys - Empty array, or array of keys. To clear the\n   *   filter, don't pass an empty array; instead, use the\n   *   {@link FilterHandle#clear} method.\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  set(keys, extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.update(this._id, keys);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * @return {string[]|null} - Either: 1) an array of keys that made it through\n   *   all of the `FilterHandle` instances, or, 2) `null`, which means no filter\n   *   is being applied (all data should be displayed).\n   */\n  get filteredKeys() {\n    return this._filterSet ? this._filterSet.value : null;\n  }\n\n  /**\n   * Subscribe to events on this `FilterHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {FilterHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link FilterHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancel event subscriptions created by {@link FilterHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|FilterHandle~listener} listener - Either the callback\n   *   function previously passed into {@link FilterHandle#on}, or the\n   *   string that was returned from {@link FilterHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  _onChange(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterVar.set(this._filterSet.value, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * @callback FilterHandle~listener\n   * @param {Object} event - An object containing details of the event. For\n   *   `\"change\"` events, this includes the properties `value` (the new\n   *   value of the filter set, or `null` if no filter set is active),\n   *   `oldValue` (the previous value of the filter set), and `sender` (the\n   *   `FilterHandle` instance that made the change).\n   */\n\n}\n\n/**\n * @event FilterHandle#change\n * @type {object}\n * @property {object} value - The new value of the filter set, or `null`\n *   if no filter set is active.\n * @property {object} oldValue - The previous value of the filter set.\n * @property {FilterHandle} sender - The `FilterHandle` instance that\n *   changed the value.\n */\n","import { diffSortedLists } from \"./util\";\n\nfunction naturalComparator(a, b) {\n  if (a === b) {\n    return 0;\n  } else if (a < b) {\n    return -1;\n  } else if (a > b) {\n    return 1;\n  }\n}\n\n/**\n * @private\n */\nexport default class FilterSet {\n  constructor() {\n    this.reset();\n  }\n\n  reset() {\n    // Key: handle ID, Value: array of selected keys, or null\n    this._handles = {};\n    // Key: key string, Value: count of handles that include it\n    this._keys = {};\n    this._value = null;\n    this._activeHandles = 0;\n  }\n\n  get value() {\n    return this._value;\n  }\n\n  update(handleId, keys) {\n    if (keys !== null) {\n      keys = keys.slice(0); // clone before sorting\n      keys.sort(naturalComparator);\n    }\n\n    let {added, removed} = diffSortedLists(this._handles[handleId], keys);\n    this._handles[handleId] = keys;\n\n    for (let i = 0; i < added.length; i++) {\n      this._keys[added[i]] = (this._keys[added[i]] || 0) + 1;\n    }\n    for (let i = 0; i < removed.length; i++) {\n      this._keys[removed[i]]--;\n    }\n\n    this._updateValue(keys);\n  }\n\n  /**\n   * @param {string[]} keys Sorted array of strings that indicate\n   * a superset of possible keys.\n   * @private\n   */\n  _updateValue(keys = this._allKeys) {\n    let handleCount = Object.keys(this._handles).length;\n    if (handleCount === 0) {\n      this._value = null;\n    } else {\n      this._value = [];\n      for (let i = 0; i < keys.length; i++) {\n        let count = this._keys[keys[i]];\n        if (count === handleCount) {\n          this._value.push(keys[i]);\n        }\n      }\n    }\n  }\n\n  clear(handleId) {\n    if (typeof(this._handles[handleId]) === \"undefined\") {\n      return;\n    }\n\n    let keys = this._handles[handleId];\n    if (!keys) {\n      keys = [];\n    }\n\n    for (let i = 0; i < keys.length; i++) {\n      this._keys[keys[i]]--;\n    }\n    delete this._handles[handleId];\n\n    this._updateValue();\n  }\n\n  get _allKeys() {\n    let allKeys = Object.keys(this._keys);\n    allKeys.sort(naturalComparator);\n    return allKeys;\n  }\n}\n","import Var from \"./var\";\n\n// Use a global so that multiple copies of crosstalk.js can be loaded and still\n// have groups behave as singletons across all copies.\nglobal.__crosstalk_groups = global.__crosstalk_groups || {};\nlet groups = global.__crosstalk_groups;\n\nexport default function group(groupName) {\n  if (groupName && typeof(groupName) === \"string\") {\n    if (!groups.hasOwnProperty(groupName)) {\n      groups[groupName] = new Group(groupName);\n    }\n    return groups[groupName];\n  } else if (typeof(groupName) === \"object\" && groupName._vars && groupName.var) {\n    // Appears to already be a group object\n    return groupName;\n  } else if (Array.isArray(groupName) &&\n      groupName.length == 1 &&\n      typeof(groupName[0]) === \"string\") {\n    return group(groupName[0]);\n  } else {\n    throw new Error(\"Invalid groupName argument\");\n  }\n}\n\nclass Group {\n  constructor(name) {\n    this.name = name;\n    this._vars = {};\n  }\n\n  var(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    if (!this._vars.hasOwnProperty(name))\n      this._vars[name] = new Var(this, name);\n    return this._vars[name];\n  }\n\n  has(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    return this._vars.hasOwnProperty(name);\n  }\n}\n","import group from \"./group\";\nimport { SelectionHandle } from \"./selection\";\nimport { FilterHandle } from \"./filter\";\nimport { bind } from \"./input\";\nimport \"./input_selectize\";\nimport \"./input_checkboxgroup\";\nimport \"./input_slider\";\n\nconst defaultGroup = group(\"default\");\n\nfunction var_(name) {\n  return defaultGroup.var(name);\n}\n\nfunction has(name) {\n  return defaultGroup.has(name);\n}\n\nif (global.Shiny) {\n  global.Shiny.addCustomMessageHandler(\"update-client-value\", function(message) {\n    if (typeof(message.group) === \"string\") {\n      group(message.group).var(message.name).set(message.value);\n    } else {\n      var_(message.name).set(message.value);\n    }\n  });\n}\n\nconst crosstalk = {\n  group: group,\n  var: var_,\n  has: has,\n  SelectionHandle: SelectionHandle,\n  FilterHandle: FilterHandle,\n  bind: bind\n};\n\n/**\n * @namespace crosstalk\n */\nexport default crosstalk;\nglobal.crosstalk = crosstalk;\n","let $ = global.jQuery;\n\nlet bindings = {};\n\nexport function register(reg) {\n  bindings[reg.className] = reg;\n  if (global.document && global.document.readyState !== \"complete\") {\n    $(() => {\n      bind();\n    });\n  } else if (global.document) {\n    setTimeout(bind, 100);\n  }\n}\n\nexport function bind() {\n  Object.keys(bindings).forEach(function(className) {\n    let binding = bindings[className];\n    $(\".\" + binding.className).not(\".crosstalk-input-bound\").each(function(i, el) {\n      bindInstance(binding, el);\n    });\n  });\n}\n\n// Escape jQuery identifier\nfunction $escape(val) {\n  return val.replace(/([!\"#$%&'()*+,./:;<=>?@[\\\\\\]^`{|}~])/g, \"\\\\$1\");\n}\n\nfunction bindEl(el) {\n  let $el = $(el);\n  Object.keys(bindings).forEach(function(className) {\n    if ($el.hasClass(className) && !$el.hasClass(\"crosstalk-input-bound\")) {\n      let binding = bindings[className];\n      bindInstance(binding, el);\n    }\n  });\n}\n\nfunction bindInstance(binding, el) {\n  let jsonEl = $(el).find(\"script[type='application/json'][data-for='\" + $escape(el.id) + \"']\");\n  let data = JSON.parse(jsonEl[0].innerText);\n\n  let instance = binding.factory(el, data);\n  $(el).data(\"crosstalk-instance\", instance);\n  $(el).addClass(\"crosstalk-input-bound\");\n}\n\nif (global.Shiny) {\n  let inputBinding = new global.Shiny.InputBinding();\n  let $ = global.jQuery;\n  $.extend(inputBinding, {\n    find: function(scope) {\n      return $(scope).find(\".crosstalk-input\");\n    },\n    initialize: function(el) {\n      if (!$(el).hasClass(\"crosstalk-input-bound\")) {\n        bindEl(el);\n      }\n    },\n    getId: function(el) {\n      return el.id;\n    },\n    getValue: function(el) {\n\n    },\n    setValue: function(el, value) {\n\n    },\n    receiveMessage: function(el, data) {\n\n    },\n    subscribe: function(el, callback) {\n      $(el).data(\"crosstalk-instance\").resume();\n    },\n    unsubscribe: function(el) {\n      $(el).data(\"crosstalk-instance\").suspend();\n    }\n  });\n  global.Shiny.inputBindings.register(inputBinding, \"crosstalk.inputBinding\");\n}\n","import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-checkboxgroup\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    let $el = $(el);\n    $el.on(\"change\", \"input[type='checkbox']\", function() {\n      let checked = $el.find(\"input[type='checkbox']:checked\");\n      if (checked.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        checked.each(function() {\n          data.map[this.value].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n","import * as input from \"./input\";\nimport * as util from \"./util\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-select\",\n\n  factory: function(el, data) {\n    /*\n     * items: {value: [...], label: [...]}\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n\n    let first = [{value: \"\", label: \"(All)\"}];\n    let items = util.dataframeToD3(data.items);\n    let opts = {\n      options: first.concat(items),\n      valueField: \"value\",\n      labelField: \"label\",\n      searchField: \"label\"\n    };\n\n    let select = $(el).find(\"select\")[0];\n\n    let selectize = $(select).selectize(opts)[0].selectize;\n\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    selectize.on(\"change\", function() {\n      if (selectize.items.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        selectize.items.forEach(function(group) {\n          data.map[group].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n","import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\nlet strftime = global.strftime;\n\ninput.register({\n  className: \"crosstalk-input-slider\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let opts = {};\n    let $el = $(el).find(\"input\");\n    let dataType = $el.data(\"data-type\");\n    let timeFormat = $el.data(\"time-format\");\n    let round = $el.data(\"round\");\n    let timeFormatter;\n\n    // Set up formatting functions\n    if (dataType === \"date\") {\n      timeFormatter = strftime.utc();\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n\n    } else if (dataType === \"datetime\") {\n      let timezone = $el.data(\"timezone\");\n      if (timezone)\n        timeFormatter = strftime.timezone(timezone);\n      else\n        timeFormatter = strftime;\n\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n    } else if (dataType === \"number\") {\n      if (typeof round !== \"undefined\")\n        opts.prettify = function(num) {\n          let factor = Math.pow(10, round);\n          return Math.round(num * factor) / factor;\n        };\n    }\n\n    $el.ionRangeSlider(opts);\n\n    function getValue() {\n      let result = $el.data(\"ionRangeSlider\").result;\n\n      // Function for converting numeric value from slider to appropriate type.\n      let convert;\n      let dataType = $el.data(\"data-type\");\n      if (dataType === \"date\") {\n        convert = function(val) {\n          return formatDateUTC(new Date(+val));\n        };\n      } else if (dataType === \"datetime\") {\n        convert = function(val) {\n          // Convert ms to s\n          return +val / 1000;\n        };\n      } else {\n        convert = function(val) { return +val; };\n      }\n\n      if ($el.data(\"ionRangeSlider\").options.type === \"double\") {\n        return [convert(result.from), convert(result.to)];\n      } else {\n        return convert(result.from);\n      }\n    }\n\n    let lastKnownKeys = null;\n\n    $el.on(\"change.crosstalkSliderInput\", function(event) {\n      if (!$el.data(\"updating\") && !$el.data(\"animating\")) {\n        let [from, to] = getValue();\n        let keys = [];\n        for (let i = 0; i < data.values.length; i++) {\n          let val = data.values[i];\n          if (val >= from && val <= to) {\n            keys.push(data.keys[i]);\n          }\n        }\n        keys.sort();\n        ctHandle.set(keys);\n        lastKnownKeys = keys;\n      }\n    });\n\n\n    // let $el = $(el);\n    // $el.on(\"change\", \"input[type=\"checkbox\"]\", function() {\n    //   let checked = $el.find(\"input[type=\"checkbox\"]:checked\");\n    //   if (checked.length === 0) {\n    //     ctHandle.clear();\n    //   } else {\n    //     let keys = {};\n    //     checked.each(function() {\n    //       data.map[this.value].forEach(function(key) {\n    //         keys[key] = true;\n    //       });\n    //     });\n    //     let keyArray = Object.keys(keys);\n    //     keyArray.sort();\n    //     ctHandle.set(keyArray);\n    //   }\n    // });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n\n\n// Convert a number to a string with leading zeros\nfunction padZeros(n, digits) {\n  let str = n.toString();\n  while (str.length < digits)\n    str = \"0\" + str;\n  return str;\n}\n\n// Given a Date object, return a string in yyyy-mm-dd format, using the\n// UTC date. This may be a day off from the date in the local time zone.\nfunction formatDateUTC(date) {\n  if (date instanceof Date) {\n    return date.getUTCFullYear() + \"-\" +\n           padZeros(date.getUTCMonth()+1, 2) + \"-\" +\n           padZeros(date.getUTCDate(), 2);\n\n  } else {\n    return null;\n  }\n}\n","import Events from \"./events\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\n/**\n * Use this class to read and write (and listen for changes to) the selection\n * for a Crosstalk group. This is intended to be used for linked brushing.\n *\n * If two (or more) `SelectionHandle` instances in the same webpage share the\n * same group name, they will share the same state. Setting the selection using\n * one `SelectionHandle` instance will result in the `value` property instantly\n * changing across the others, and `\"change\"` event listeners on all instances\n * (including the one that initiated the sending) will fire.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the [SelectionHandle#setGroup](#setGroup) method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class SelectionHandle {\n\n  constructor(group = null, extraInfo = null) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._var = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this SelectionHandle. The group\n   * being switched away from (if any) will not have its selection value\n   * modified as a result of calling `setGroup`, even if this handle was the\n   * most recent handle to set the selection of the group.\n   *\n   * The group being switched to (if any) will also not have its selection value\n   * modified as a result of calling `setGroup`. If you want to set the\n   * selection value of the new group, call `set` explicitly.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._var) {\n      this._var.off(\"change\", this._varOnChangeSub);\n      this._var = null;\n      this._varOnChangeSub = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      this._var = grp(group).var(\"selection\");\n      let sub = this._var.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Retrieves the current selection for the group represented by this\n   * `SelectionHandle`.\n   *\n   * - If no selection is active, then this value will be falsy.\n   * - If a selection is active, but no data points are selected, then this\n   *   value will be an empty array.\n   * - If a selection is active, and data points are selected, then the keys\n   *   of the selected data points will be present in the array.\n   */\n  get value() {\n    return this._var ? this._var.get() : null;\n  }\n\n  /**\n   * Combines the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    // Important incidental effect: shallow clone is returned\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {string[]} selectedKeys - Falsy, empty array, or array of keys (see\n   *   {@link SelectionHandle#value}).\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `SelectionHandle` constructor).\n   */\n  set(selectedKeys, extraInfo) {\n    if (this._var)\n      this._var.set(selectedKeys, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any that were passed\n   *   into the `SelectionHandle` constructor).\n   */\n  clear(extraInfo) {\n    if (this._var)\n      this.set(void 0, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Subscribes to events on this `SelectionHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {SelectionHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link SelectionHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancels event subscriptions created by {@link SelectionHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|SelectionHandle~listener} listener - Either the callback\n   *   function previously passed into {@link SelectionHandle#on}, or the\n   *   string that was returned from {@link SelectionHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  /**\n   * Shuts down the `SelectionHandle` object.\n   *\n   * Removes all event listeners that were added through this handle.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.setGroup(null);\n  }\n}\n\n/**\n * @callback SelectionHandle~listener\n * @param {Object} event - An object containing details of the event. For\n *   `\"change\"` events, this includes the properties `value` (the new\n *   value of the selection, or `undefined` if no selection is active),\n *   `oldValue` (the previous value of the selection), and `sender` (the\n *   `SelectionHandle` instance that made the change).\n */\n\n/**\n * @event SelectionHandle#change\n * @type {object}\n * @property {object} value - The new value of the selection, or `undefined`\n *   if no selection is active.\n * @property {object} oldValue - The previous value of the selection.\n * @property {SelectionHandle} sender - The `SelectionHandle` instance that\n *   changed the value.\n */\n","export function extend(target, ...sources) {\n  for (let i = 0; i < sources.length; i++) {\n    let src = sources[i];\n    if (typeof(src) === \"undefined\" || src === null)\n      continue;\n\n    for (let key in src) {\n      if (src.hasOwnProperty(key)) {\n        target[key] = src[key];\n      }\n    }\n  }\n  return target;\n}\n\nexport function checkSorted(list) {\n  for (let i = 1; i < list.length; i++) {\n    if (list[i] <= list[i-1]) {\n      throw new Error(\"List is not sorted or contains duplicate\");\n    }\n  }\n}\n\nexport function diffSortedLists(a, b) {\n  let i_a = 0;\n  let i_b = 0;\n\n  if (!a) a = [];\n  if (!b) b = [];\n\n  let a_only = [];\n  let b_only = [];\n\n  checkSorted(a);\n  checkSorted(b);\n\n  while (i_a < a.length && i_b < b.length) {\n    if (a[i_a] === b[i_b]) {\n      i_a++;\n      i_b++;\n    } else if (a[i_a] < b[i_b]) {\n      a_only.push(a[i_a++]);\n    } else {\n      b_only.push(b[i_b++]);\n    }\n  }\n\n  if (i_a < a.length)\n    a_only = a_only.concat(a.slice(i_a));\n  if (i_b < b.length)\n    b_only = b_only.concat(b.slice(i_b));\n  return {\n    removed: a_only,\n    added: b_only\n  };\n}\n\n// Convert from wide: { colA: [1,2,3], colB: [4,5,6], ... }\n// to long: [ {colA: 1, colB: 4}, {colA: 2, colB: 5}, ... ]\nexport function dataframeToD3(df) {\n  let names = [];\n  let length;\n  for (let name in df) {\n    if (df.hasOwnProperty(name))\n      names.push(name);\n    if (typeof(df[name]) !== \"object\" || typeof(df[name].length) === \"undefined\") {\n      throw new Error(\"All fields must be arrays\");\n    } else if (typeof(length) !== \"undefined\" && length !== df[name].length) {\n      throw new Error(\"All fields must be arrays of the same length\");\n    }\n    length = df[name].length;\n  }\n  let results = [];\n  let item;\n  for (let row = 0; row < length; row++) {\n    item = {};\n    for (let col = 0; col < names.length; col++) {\n      item[names[col]] = df[names[col]][row];\n    }\n    results.push(item);\n  }\n  return results;\n}\n\n/**\n * Keeps track of all event listener additions/removals and lets all active\n * listeners be removed with a single operation.\n *\n * @private\n */\nexport class SubscriptionTracker {\n  constructor(emitter) {\n    this._emitter = emitter;\n    this._subs = {};\n  }\n\n  on(eventType, listener) {\n    let sub = this._emitter.on(eventType, listener);\n    this._subs[sub] = eventType;\n    return sub;\n  }\n\n  off(eventType, listener) {\n    let sub = this._emitter.off(eventType, listener);\n    if (sub) {\n      delete this._subs[sub];\n    }\n    return sub;\n  }\n\n  removeAllListeners() {\n    let current_subs = this._subs;\n    this._subs = {};\n    Object.keys(current_subs).forEach((sub) => {\n      this._emitter.off(current_subs[sub], sub);\n    });\n  }\n}\n","import Events from \"./events\";\n\nexport default class Var {\n  constructor(group, name, /*optional*/ value) {\n    this._group = group;\n    this._name = name;\n    this._value = value;\n    this._events = new Events();\n  }\n\n  get() {\n    return this._value;\n  }\n\n  set(value, /*optional*/ event) {\n    if (this._value === value) {\n      // Do nothing; the value hasn't changed\n      return;\n    }\n    let oldValue = this._value;\n    this._value = value;\n    // Alert JavaScript listeners that the value has changed\n    let evt = {};\n    if (event && typeof(event) === \"object\") {\n      for (let k in event) {\n        if (event.hasOwnProperty(k))\n          evt[k] = event[k];\n      }\n    }\n    evt.oldValue = oldValue;\n    evt.value = value;\n    this._events.trigger(\"change\", evt, this);\n\n    // TODO: Make this extensible, to let arbitrary back-ends know that\n    // something has changed\n    if (global.Shiny && global.Shiny.onInputChange) {\n      global.Shiny.onInputChange(\n        \".clientValue-\" +\n          (this._group.name !== null ? this._group.name + \"-\" : \"\") +\n          this._name,\n        typeof(value) === \"undefined\" ? null : value\n      );\n    }\n  }\n\n  on(eventType, listener) {\n    return this._events.on(eventType, listener);\n  }\n\n  off(eventType, listener) {\n    return this._events.off(eventType, listener);\n  }\n}\n"]}
\ No newline at end of file
diff --git a/docs/articles/S2_EDA_files/crosstalk-1.2.1/scss/crosstalk.scss b/docs/articles/S2_EDA_files/crosstalk-1.2.1/scss/crosstalk.scss
new file mode 100644
index 0000000..3566561
--- /dev/null
+++ b/docs/articles/S2_EDA_files/crosstalk-1.2.1/scss/crosstalk.scss
@@ -0,0 +1,75 @@
+/* Adjust margins outwards, so column contents line up with the edges of the
+   parent of container-fluid. */
+.container-fluid.crosstalk-bscols {
+  margin-left: -30px;
+  margin-right: -30px;
+  white-space: normal;
+}
+
+/* But don't adjust the margins outwards if we're directly under the body,
+   i.e. we were the top-level of something at the console. */
+body > .container-fluid.crosstalk-bscols {
+  margin-left: auto;
+  margin-right: auto;
+}
+
+.crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column {
+  display: inline-block;
+  padding-right: 12px;
+  vertical-align: top;
+}
+
+@media only screen and (max-width:480px) {
+  .crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column {
+    display: block;
+    padding-right: inherit;
+  }
+}
+
+/* Relevant BS3 styles to make filter_checkbox() look reasonable without Bootstrap */
+.crosstalk-input {
+  margin-bottom: 15px; /* a la .form-group */
+  .control-label {
+    margin-bottom: 0;
+    vertical-align: middle;
+  }
+  input[type="checkbox"] {
+    margin: 4px 0 0;
+    margin-top: 1px;
+    line-height: normal;
+  }
+  .checkbox {
+    position: relative;
+    display: block;
+    margin-top: 10px;
+    margin-bottom: 10px;
+  }
+  .checkbox > label{
+    padding-left: 20px;
+    margin-bottom: 0;
+    font-weight: 400;
+    cursor: pointer;
+  }
+  .checkbox input[type="checkbox"],
+  .checkbox-inline input[type="checkbox"] {
+    position: absolute;
+    margin-top: 2px;
+    margin-left: -20px;
+  }
+  .checkbox + .checkbox {
+    margin-top: -5px;
+  }
+  .checkbox-inline {
+    position: relative;
+    display: inline-block;
+    padding-left: 20px;
+    margin-bottom: 0;
+    font-weight: 400;
+    vertical-align: middle;
+    cursor: pointer;
+  }
+  .checkbox-inline + .checkbox-inline {
+    margin-top: 0;
+    margin-left: 10px;
+  }
+}
diff --git a/docs/articles/S2_EDA_files/datatables-binding-0.33/datatables.js b/docs/articles/S2_EDA_files/datatables-binding-0.33/datatables.js
new file mode 100644
index 0000000..765b53c
--- /dev/null
+++ b/docs/articles/S2_EDA_files/datatables-binding-0.33/datatables.js
@@ -0,0 +1,1539 @@
+(function() {
+
+// some helper functions: using a global object DTWidget so that it can be used
+// in JS() code, e.g. datatable(options = list(foo = JS('code'))); unlike R's
+// dynamic scoping, when 'code' is eval'ed, JavaScript does not know objects
+// from the "parent frame", e.g. JS('DTWidget') will not work unless it was made
+// a global object
+var DTWidget = {};
+
+// 123456666.7890 -> 123,456,666.7890
+var markInterval = function(d, digits, interval, mark, decMark, precision) {
+  x = precision ? d.toPrecision(digits) : d.toFixed(digits);
+  if (!/^-?[\d.]+$/.test(x)) return x;
+  var xv = x.split('.');
+  if (xv.length > 2) return x;  // should have at most one decimal point
+  xv[0] = xv[0].replace(new RegExp('\\B(?=(\\d{' + interval + '})+(?!\\d))', 'g'), mark);
+  return xv.join(decMark);
+};
+
+DTWidget.formatCurrency = function(data, currency, digits, interval, mark, decMark, before, zeroPrint) {
+  var d = parseFloat(data);
+  if (isNaN(d)) return '';
+  if (zeroPrint !== null && d === 0.0) return zeroPrint;
+  var res = markInterval(d, digits, interval, mark, decMark);
+  res = before ? (/^-/.test(res) ? '-' + currency + res.replace(/^-/, '') : currency + res) :
+    res + currency;
+  return res;
+};
+
+DTWidget.formatString = function(data, prefix, suffix) {
+  var d = data;
+  if (d === null) return '';
+  return prefix + d + suffix;
+};
+
+DTWidget.formatPercentage = function(data, digits, interval, mark, decMark, zeroPrint) {
+  var d = parseFloat(data);
+  if (isNaN(d)) return '';
+  if (zeroPrint !== null && d === 0.0) return zeroPrint;
+  return markInterval(d * 100, digits, interval, mark, decMark) + '%';
+};
+
+DTWidget.formatRound = function(data, digits, interval, mark, decMark, zeroPrint) {
+  var d = parseFloat(data);
+  if (isNaN(d)) return '';
+  if (zeroPrint !== null && d === 0.0) return zeroPrint;
+  return markInterval(d, digits, interval, mark, decMark);
+};
+
+DTWidget.formatSignif = function(data, digits, interval, mark, decMark, zeroPrint) {
+  var d = parseFloat(data);
+  if (isNaN(d)) return '';
+  if (zeroPrint !== null && d === 0.0) return zeroPrint;
+  return markInterval(d, digits, interval, mark, decMark, true);
+};
+
+DTWidget.formatDate = function(data, method, params) {
+  var d = data;
+  if (d === null) return '';
+  // (new Date('2015-10-28')).toDateString() may return 2015-10-27 because the
+  // actual time created could be like 'Tue Oct 27 2015 19:00:00 GMT-0500 (CDT)',
+  // i.e. the date-only string is treated as UTC time instead of local time
+  if ((method === 'toDateString' || method === 'toLocaleDateString') && /^\d{4,}\D\d{2}\D\d{2}$/.test(d)) {
+    d = d.split(/\D/);
+    d = new Date(d[0], d[1] - 1, d[2]);
+  } else {
+    d = new Date(d);
+  }
+  return d[method].apply(d, params);
+};
+
+window.DTWidget = DTWidget;
+
+// A helper function to update the properties of existing filters
+var setFilterProps = function(td, props) {
+  // Update enabled/disabled state
+  var $input = $(td).find('input').first();
+  var searchable = $input.data('searchable');
+  $input.prop('disabled', !searchable || props.disabled);
+
+  // Based on the filter type, set its new values
+  var type = td.getAttribute('data-type');
+  if (['factor', 'logical'].includes(type)) {
+    // Reformat the new dropdown options for use with selectize
+    var new_vals = props.params.options.map(function(item) {
+      return { text: item, value: item };
+    });
+
+    // Find the selectize object
+    var dropdown = $(td).find('.selectized').eq(0)[0].selectize;
+
+    // Note the current values
+    var old_vals = dropdown.getValue();
+
+    // Remove the existing values
+    dropdown.clearOptions();
+
+    // Add the new options
+    dropdown.addOption(new_vals);
+
+    // Preserve the existing values
+    dropdown.setValue(old_vals);
+
+  } else if (['number', 'integer', 'date', 'time'].includes(type)) {
+    // Apply internal scaling to new limits. Updating scale not yet implemented.
+    var slider = $(td).find('.noUi-target').eq(0);
+    var scale = Math.pow(10, Math.max(0, +slider.data('scale') || 0));
+    var new_vals = [props.params.min * scale, props.params.max * scale];
+
+    // Note what the new limits will be just for this filter
+    var new_lims = new_vals.slice();
+
+    // Determine the current values and limits
+    var old_vals = slider.val().map(Number);
+    var old_lims = slider.noUiSlider('options').range;
+    old_lims = [old_lims.min, old_lims.max];
+
+    // Preserve the current values if filters have been applied; otherwise, apply no filtering
+    if (old_vals[0] != old_lims[0]) {
+      new_vals[0] = Math.max(old_vals[0], new_vals[0]);
+    }
+
+    if (old_vals[1] != old_lims[1]) {
+      new_vals[1] = Math.min(old_vals[1], new_vals[1]);
+    }
+
+    // Update the endpoints of the slider
+    slider.noUiSlider({
+      start: new_vals,
+      range: {'min': new_lims[0], 'max': new_lims[1]}
+    }, true);
+  }
+};
+
+var transposeArray2D = function(a) {
+  return a.length === 0 ? a : HTMLWidgets.transposeArray2D(a);
+};
+
+var crosstalkPluginsInstalled = false;
+
+function maybeInstallCrosstalkPlugins() {
+  if (crosstalkPluginsInstalled)
+    return;
+  crosstalkPluginsInstalled = true;
+
+  $.fn.dataTable.ext.afnFiltering.push(
+    function(oSettings, aData, iDataIndex) {
+      var ctfilter = oSettings.nTable.ctfilter;
+      if (ctfilter && !ctfilter[iDataIndex])
+        return false;
+
+      var ctselect = oSettings.nTable.ctselect;
+      if (ctselect && !ctselect[iDataIndex])
+        return false;
+
+      return true;
+    }
+  );
+}
+
+HTMLWidgets.widget({
+  name: "datatables",
+  type: "output",
+  renderOnNullValue: true,
+  initialize: function(el, width, height) {
+    // in order that the type=number inputs return a number
+    $.valHooks.number = {
+      get: function(el) {
+        var value = parseFloat(el.value);
+        return isNaN(value) ? "" : value;
+      }
+    };
+    $(el).html('&nbsp;');
+    return {
+      data: null,
+      ctfilterHandle: new crosstalk.FilterHandle(),
+      ctfilterSubscription: null,
+      ctselectHandle: new crosstalk.SelectionHandle(),
+      ctselectSubscription: null
+    };
+  },
+  renderValue: function(el, data, instance) {
+    if (el.offsetWidth === 0 || el.offsetHeight === 0) {
+      instance.data = data;
+      return;
+    }
+    instance.data = null;
+    var $el = $(el);
+    $el.empty();
+
+    if (data === null) {
+      $el.append('&nbsp;');
+      // clear previous Shiny inputs (if any)
+      for (var i in instance.clearInputs) instance.clearInputs[i]();
+      instance.clearInputs = {};
+      return;
+    }
+
+    var crosstalkOptions = data.crosstalkOptions;
+    if (!crosstalkOptions) crosstalkOptions = {
+      'key': null, 'group': null
+    };
+    if (crosstalkOptions.group) {
+      maybeInstallCrosstalkPlugins();
+      instance.ctfilterHandle.setGroup(crosstalkOptions.group);
+      instance.ctselectHandle.setGroup(crosstalkOptions.group);
+    }
+
+    // if we are in the viewer then we always want to fillContainer and
+    // and autoHideNavigation (unless the user has explicitly set these)
+    if (window.HTMLWidgets.viewerMode) {
+      if (!data.hasOwnProperty("fillContainer"))
+        data.fillContainer = true;
+      if (!data.hasOwnProperty("autoHideNavigation"))
+        data.autoHideNavigation = true;
+    }
+
+    // propagate fillContainer to instance (so we have it in resize)
+    instance.fillContainer = data.fillContainer;
+
+    var cells = data.data;
+
+    if (cells instanceof Array) cells = transposeArray2D(cells);
+
+    $el.append(data.container);
+    var $table = $el.find('table');
+    if (data.class) $table.addClass(data.class);
+    if (data.caption) $table.prepend(data.caption);
+
+    if (!data.selection) data.selection = {
+      mode: 'none', selected: null, target: 'row', selectable: null
+    };
+    if (HTMLWidgets.shinyMode && data.selection.mode !== 'none' &&
+        data.selection.target === 'row+column') {
+      if ($table.children('tfoot').length === 0) {
+        $table.append($('<tfoot>'));
+        $table.find('thead tr').clone().appendTo($table.find('tfoot'));
+      }
+    }
+
+    // column filters
+    var filterRow;
+    switch (data.filter) {
+      case 'top':
+        $table.children('thead').append(data.filterHTML);
+        filterRow = $table.find('thead tr:last td');
+        break;
+      case 'bottom':
+        if ($table.children('tfoot').length === 0) {
+          $table.append($('<tfoot>'));
+        }
+        $table.children('tfoot').prepend(data.filterHTML);
+        filterRow = $table.find('tfoot tr:first td');
+        break;
+    }
+
+    var options = { searchDelay: 1000 };
+    if (cells !== null) $.extend(options, {
+      data: cells
+    });
+
+    // options for fillContainer
+    var bootstrapActive = typeof($.fn.popover) != 'undefined';
+    if (instance.fillContainer) {
+
+      // force scrollX/scrollY and turn off autoWidth
+      options.scrollX = true;
+      options.scrollY = "100px"; // can be any value, we'll adjust below
+
+      // if we aren't paginating then move around the info/filter controls
+      // to save space at the bottom and rephrase the info callback
+      if (data.options.paging === false) {
+
+        // we know how to do this cleanly for bootstrap, not so much
+        // for other themes/layouts
+        if (bootstrapActive) {
+          options.dom = "<'row'<'col-sm-4'i><'col-sm-8'f>>" +
+                        "<'row'<'col-sm-12'tr>>";
+        }
+
+        options.fnInfoCallback = function(oSettings, iStart, iEnd,
+                                           iMax, iTotal, sPre) {
+          return Number(iTotal).toLocaleString() + " records";
+        };
+      }
+    }
+
+    // auto hide navigation if requested
+    // Note, this only works on client-side processing mode as on server-side,
+    // cells (data.data) is null; In addition, we require the pageLength option
+    // being provided explicitly to enable this. Despite we may be able to deduce
+    // the default value of pageLength, it may complicate things so we'd rather
+    // put this responsiblity to users and warn them on the R side.
+    if (data.autoHideNavigation === true && data.options.paging !== false) {
+      // strip all nav if length >= cells
+      if ((cells instanceof Array) && data.options.pageLength >= cells.length)
+        options.dom = bootstrapActive ? "<'row'<'col-sm-12'tr>>" : "t";
+      // alternatively lean things out for flexdashboard mobile portrait
+      else if (bootstrapActive && window.FlexDashboard && window.FlexDashboard.isMobilePhone())
+        options.dom = "<'row'<'col-sm-12'f>>" +
+                      "<'row'<'col-sm-12'tr>>"  +
+                      "<'row'<'col-sm-12'p>>";
+    }
+
+    $.extend(true, options, data.options || {});
+
+    var searchCols = options.searchCols;
+    if (searchCols) {
+      searchCols = searchCols.map(function(x) {
+        return x === null ? '' : x.search;
+      });
+      // FIXME: this means I don't respect the escapeRegex setting
+      delete options.searchCols;
+    }
+
+    // server-side processing?
+    var server = options.serverSide === true;
+
+    // use the dataSrc function to pre-process JSON data returned from R
+    var DT_rows_all = [], DT_rows_current = [];
+    if (server && HTMLWidgets.shinyMode && typeof options.ajax === 'object' &&
+        /^session\/[\da-z]+\/dataobj/.test(options.ajax.url) && !options.ajax.dataSrc) {
+      options.ajax.dataSrc = function(json) {
+        DT_rows_all = $.makeArray(json.DT_rows_all);
+        DT_rows_current = $.makeArray(json.DT_rows_current);
+        var data = json.data;
+        if (!colReorderEnabled()) return data;
+        var table = $table.DataTable(), order = table.colReorder.order(), flag = true, i, j, row;
+        for (i = 0; i < order.length; ++i) if (order[i] !== i) flag = false;
+        if (flag) return data;
+        for (i = 0; i < data.length; ++i) {
+          row = data[i].slice();
+          for (j = 0; j < order.length; ++j) data[i][j] = row[order[j]];
+        }
+        return data;
+      };
+    }
+
+    var thiz = this;
+    if (instance.fillContainer) $table.on('init.dt', function(e) {
+      thiz.fillAvailableHeight(el, $(el).innerHeight());
+    });
+    // If the page contains serveral datatables and one of which enables colReorder,
+    // the table.colReorder.order() function will exist but throws error when called.
+    // So it seems like the only way to know if colReorder is enabled or not is to
+    // check the options.
+    var colReorderEnabled = function() { return "colReorder" in options; };
+    var table = $table.DataTable(options);
+    $el.data('datatable', table);
+
+    if ('rowGroup' in options) {
+      // Maintain RowGroup dataSrc when columns are reordered (#1109)
+      table.on('column-reorder', function(e, settings, details) {
+        var oldDataSrc = table.rowGroup().dataSrc();
+        var newDataSrc = details.mapping[oldDataSrc];
+        table.rowGroup().dataSrc(newDataSrc);
+      });
+    }
+
+    // Unregister previous Crosstalk event subscriptions, if they exist
+    if (instance.ctfilterSubscription) {
+      instance.ctfilterHandle.off("change", instance.ctfilterSubscription);
+      instance.ctfilterSubscription = null;
+    }
+    if (instance.ctselectSubscription) {
+      instance.ctselectHandle.off("change", instance.ctselectSubscription);
+      instance.ctselectSubscription = null;
+    }
+
+    if (!crosstalkOptions.group) {
+      $table[0].ctfilter = null;
+      $table[0].ctselect = null;
+    } else {
+      var key = crosstalkOptions.key;
+      function keysToMatches(keys) {
+        if (!keys) {
+          return null;
+        } else {
+          var selectedKeys = {};
+          for (var i = 0; i < keys.length; i++) {
+            selectedKeys[keys[i]] = true;
+          }
+          var matches = {};
+          for (var j = 0; j < key.length; j++) {
+            if (selectedKeys[key[j]])
+              matches[j] = true;
+          }
+          return matches;
+        }
+      }
+
+      function applyCrosstalkFilter(e) {
+        $table[0].ctfilter = keysToMatches(e.value);
+        table.draw();
+      }
+      instance.ctfilterSubscription = instance.ctfilterHandle.on("change", applyCrosstalkFilter);
+      applyCrosstalkFilter({value: instance.ctfilterHandle.filteredKeys});
+
+      function applyCrosstalkSelection(e) {
+        if (e.sender !== instance.ctselectHandle) {
+          table
+            .rows('.' + selClass, {search: 'applied'})
+            .nodes()
+            .to$()
+            .removeClass(selClass);
+          if (selectedRows)
+            changeInput('rows_selected', selectedRows(), void 0, true);
+        }
+
+        if (e.sender !== instance.ctselectHandle && e.value && e.value.length) {
+          var matches = keysToMatches(e.value);
+
+          // persistent selection with plotly (& leaflet)
+          var ctOpts = crosstalk.var("plotlyCrosstalkOpts").get() || {};
+          if (ctOpts.persistent === true) {
+            var matches = $.extend(matches, $table[0].ctselect);
+          }
+
+          $table[0].ctselect = matches;
+          table.draw();
+        } else {
+          if ($table[0].ctselect) {
+            $table[0].ctselect = null;
+            table.draw();
+          }
+        }
+      }
+      instance.ctselectSubscription = instance.ctselectHandle.on("change", applyCrosstalkSelection);
+      // TODO: This next line doesn't seem to work when renderDataTable is used
+      applyCrosstalkSelection({value: instance.ctselectHandle.value});
+    }
+
+    var inArray = function(val, array) {
+      return $.inArray(val, $.makeArray(array)) > -1;
+    };
+
+    // search the i-th column
+    var searchColumn = function(i, value) {
+      var regex = false, ci = true;
+      if (options.search) {
+        regex = options.search.regex,
+        ci = options.search.caseInsensitive !== false;
+      }
+      // need to transpose the column index when colReorder is enabled
+      if (table.colReorder) i = table.colReorder.transpose(i);
+      return table.column(i).search(value, regex, !regex, ci);
+    };
+
+    if (data.filter !== 'none') {
+      if (!data.hasOwnProperty('filterSettings')) data.filterSettings = {};
+
+      filterRow.each(function(i, td) {
+
+        var $td = $(td), type = $td.data('type'), filter;
+        var $input = $td.children('div').first().children('input');
+        var disabled = $input.prop('disabled');
+        var searchable = table.settings()[0].aoColumns[i].bSearchable;
+        $input.prop('disabled', !searchable || disabled);
+        $input.data('searchable', searchable); // for updating later
+        $input.on('input blur', function() {
+          $input.next('span').toggle(Boolean($input.val()));
+        });
+        // Bootstrap sets pointer-events to none and we won't be able to click
+        // the clear button
+        $input.next('span').css('pointer-events', 'auto').hide().click(function() {
+          $(this).hide().prev('input').val('').trigger('input').focus();
+        });
+        var searchCol;  // search string for this column
+        if (searchCols && searchCols[i]) {
+          searchCol = searchCols[i];
+          $input.val(searchCol).trigger('input');
+        }
+        var $x = $td.children('div').last();
+
+        // remove the overflow: hidden attribute of the scrollHead
+        // (otherwise the scrolling table body obscures the filters)
+        // The workaround and the discussion from
+        // https://github.com/rstudio/DT/issues/554#issuecomment-518007347
+        // Otherwise the filter selection will not be anchored to the values
+        // when the columns number is many and scrollX is enabled.
+        var scrollHead = $(el).find('.dataTables_scrollHead,.dataTables_scrollFoot');
+        var cssOverflowHead = scrollHead.css('overflow');
+        var scrollBody = $(el).find('.dataTables_scrollBody');
+        var cssOverflowBody = scrollBody.css('overflow');
+        var scrollTable = $(el).find('.dataTables_scroll');
+        var cssOverflowTable = scrollTable.css('overflow');
+        if (cssOverflowHead === 'hidden') {
+          $x.on('show hide', function(e) {
+            if (e.type === 'show') {
+              scrollHead.css('overflow', 'visible');
+              scrollBody.css('overflow', 'visible');
+              scrollTable.css('overflow-x', 'scroll');
+            } else {
+              scrollHead.css('overflow', cssOverflowHead);
+              scrollBody.css('overflow', cssOverflowBody);
+              scrollTable.css('overflow-x', cssOverflowTable);
+            }
+          });
+          $x.css('z-index', 25);
+        }
+
+        if (inArray(type, ['factor', 'logical'])) {
+          $input.on({
+            click: function() {
+              $input.parent().hide(); $x.show().trigger('show'); filter[0].selectize.focus();
+            },
+            input: function() {
+              var v1 = JSON.stringify(filter[0].selectize.getValue()), v2 = $input.val();
+              if (v1 === '[]') v1 = '';
+              if (v1 !== v2) filter[0].selectize.setValue(v2 === '' ? [] : JSON.parse(v2));
+            }
+          });
+          var $input2 = $x.children('select');
+          filter = $input2.selectize($.extend({
+            options: $input2.data('options').map(function(v, i) {
+              return ({text: v, value: v});
+            }),
+            plugins: ['remove_button'],
+            hideSelected: true,
+            onChange: function(value) {
+              if (value === null) value = []; // compatibility with jQuery 3.0
+              $input.val(value.length ? JSON.stringify(value) : '');
+              if (value.length) $input.trigger('input');
+              $input.attr('title', $input.val());
+              if (server) {
+                searchColumn(i, value.length ? JSON.stringify(value) : '').draw();
+                return;
+              }
+              // turn off filter if nothing selected
+              $td.data('filter', value.length > 0);
+              table.draw();  // redraw table, and filters will be applied
+            }
+          }, data.filterSettings.select));
+          filter[0].selectize.on('blur', function() {
+            $x.hide().trigger('hide'); $input.parent().show(); $input.trigger('blur');
+          });
+          filter.next('div').css('margin-bottom', 'auto');
+        } else if (type === 'character') {
+          var fun = function() {
+            searchColumn(i, $input.val()).draw();
+          };
+          // throttle searching for server-side processing
+          var throttledFun = $.fn.dataTable.util.throttle(fun, options.searchDelay);
+          $input.on('input', function(e, immediate) {
+            // always bypass throttling when immediate = true (via the updateSearch method)
+            (immediate || !server) ? fun() : throttledFun();
+          });
+        } else if (inArray(type, ['number', 'integer', 'date', 'time'])) {
+          var $x0 = $x;
+          $x = $x0.children('div').first();
+          $x0.css({
+            'background-color': '#fff',
+            'border': '1px #ddd solid',
+            'border-radius': '4px',
+            'padding': data.vertical ? '35px 20px': '20px 20px 10px 20px'
+          });
+          var $spans = $x0.children('span').css({
+            'margin-top': data.vertical ? '0' : '10px',
+            'white-space': 'nowrap'
+          });
+          var $span1 = $spans.first(), $span2 = $spans.last();
+          var r1 = +$x.data('min'), r2 = +$x.data('max');
+          // when the numbers are too small or have many decimal places, the
+          // slider may have numeric precision problems (#150)
+          var scale = Math.pow(10, Math.max(0, +$x.data('scale') || 0));
+          r1 = Math.round(r1 * scale); r2 = Math.round(r2 * scale);
+          var scaleBack = function(x, scale) {
+            if (scale === 1) return x;
+            var d = Math.round(Math.log(scale) / Math.log(10));
+            // to avoid problems like 3.423/100 -> 0.034230000000000003
+            return (x / scale).toFixed(d);
+          };
+          var slider_min = function() {
+            return filter.noUiSlider('options').range.min;
+          };
+          var slider_max = function() {
+            return filter.noUiSlider('options').range.max;
+          };
+          $input.on({
+            focus: function() {
+              $x0.show().trigger('show');
+              // first, make sure the slider div leaves at least 20px between
+              // the two (slider value) span's
+              $x0.width(Math.max(160, $span1.outerWidth() + $span2.outerWidth() + 20));
+              // then, if the input is really wide or slider is vertical,
+              // make the slider the same width as the input
+              if ($x0.outerWidth() < $input.outerWidth() || data.vertical) {
+                $x0.outerWidth($input.outerWidth());
+              }
+              // make sure the slider div does not reach beyond the right margin
+              if ($(window).width() < $x0.offset().left + $x0.width()) {
+                $x0.offset({
+                  'left': $input.offset().left + $input.outerWidth() - $x0.outerWidth()
+                });
+              }
+            },
+            blur: function() {
+              $x0.hide().trigger('hide');
+            },
+            input: function() {
+              if ($input.val() === '') filter.val([slider_min(), slider_max()]);
+            },
+            change: function() {
+              var v = $input.val().replace(/\s/g, '');
+              if (v === '') return;
+              v = v.split('...');
+              if (v.length !== 2) {
+                $input.parent().addClass('has-error');
+                return;
+              }
+              if (v[0] === '') v[0] = slider_min();
+              if (v[1] === '') v[1] = slider_max();
+              $input.parent().removeClass('has-error');
+              // treat date as UTC time at midnight
+              var strTime = function(x) {
+                var s = type === 'date' ? 'T00:00:00Z' : '';
+                var t = new Date(x + s).getTime();
+                // add 10 minutes to date since it does not hurt the date, and
+                // it helps avoid the tricky floating point arithmetic problems,
+                // e.g. sometimes the date may be a few milliseconds earlier
+                // than the midnight due to precision problems in noUiSlider
+                return type === 'date' ? t + 3600000 : t;
+              };
+              if (inArray(type, ['date', 'time'])) {
+                v[0] = strTime(v[0]);
+                v[1] = strTime(v[1]);
+              }
+              if (v[0] != slider_min()) v[0] *= scale;
+              if (v[1] != slider_max()) v[1] *= scale;
+              filter.val(v);
+            }
+          });
+          var formatDate = function(d) {
+            d = scaleBack(d, scale);
+            if (type === 'number') return d;
+            if (type === 'integer') return parseInt(d);
+            var x = new Date(+d);
+            if (type === 'date') {
+              var pad0 = function(x) {
+                return ('0' + x).substr(-2, 2);
+              };
+              return x.getUTCFullYear() + '-' + pad0(1 + x.getUTCMonth())
+                      + '-' + pad0(x.getUTCDate());
+            } else {
+              return x.toISOString();
+            }
+          };
+          var opts = type === 'date' ? { step: 60 * 60 * 1000 } :
+                     type === 'integer' ? { step: 1 } : {};
+
+          opts.orientation = data.vertical ? 'vertical': 'horizontal';
+          opts.direction = data.vertical ? 'rtl': 'ltr';
+
+          filter = $x.noUiSlider($.extend({
+            start: [r1, r2],
+            range: {min: r1, max: r2},
+            connect: true
+          }, opts, data.filterSettings.slider));
+          if (scale > 1) (function() {
+            var t1 = r1, t2 = r2;
+            var val = filter.val();
+            while (val[0] > r1 || val[1] < r2) {
+              if (val[0] > r1) {
+                t1 -= val[0] - r1;
+              }
+              if (val[1] < r2) {
+                t2 += r2 - val[1];
+              }
+              filter = $x.noUiSlider($.extend({
+                start: [t1, t2],
+                range: {min: t1, max: t2},
+                connect: true
+              }, opts, data.filterSettings.slider), true);
+              val = filter.val();
+            }
+            r1  = t1; r2 = t2;
+          })();
+          // format with active column renderer, if defined
+          var colDef = data.options.columnDefs.find(function(def) {
+            return (def.targets === i || inArray(i, def.targets)) && 'render' in def;
+          });
+          var updateSliderText = function(v1, v2) {
+            // we only know how to use function renderers
+            if (colDef && typeof colDef.render === 'function') {
+              var restore = function(v) {
+                v = scaleBack(v, scale);
+                return inArray(type, ['date', 'time']) ? new Date(+v) : v;
+              }
+              $span1.text(colDef.render(restore(v1), 'display'));
+              $span2.text(colDef.render(restore(v2), 'display'));
+            } else {
+              $span1.text(formatDate(v1));
+              $span2.text(formatDate(v2));
+            }
+          };
+          updateSliderText(r1, r2);
+          var updateSlider = function(e) {
+            var val = filter.val();
+            // turn off filter if in full range
+            $td.data('filter', val[0] > slider_min() || val[1] < slider_max());
+            var v1 = formatDate(val[0]), v2 = formatDate(val[1]), ival;
+            if ($td.data('filter')) {
+              ival = v1 + ' ... ' + v2;
+              $input.attr('title', ival).val(ival).trigger('input');
+            } else {
+              $input.attr('title', '').val('');
+            }
+            updateSliderText(val[0], val[1]);
+            if (e.type === 'slide') return;  // no searching when sliding only
+            if (server) {
+              searchColumn(i, $td.data('filter') ? ival : '').draw();
+              return;
+            }
+            table.draw();
+          };
+          filter.on({
+            set: updateSlider,
+            slide: updateSlider
+          });
+        }
+
+        // server-side processing will be handled by R (or whatever server
+        // language you use); the following code is only needed for client-side
+        // processing
+        if (server) {
+          // if a search string has been pre-set, search now
+          if (searchCol) $input.trigger('input').trigger('change');
+          return;
+        }
+
+        var customFilter = function(settings, data, dataIndex) {
+          // there is no way to attach a search function to a specific table,
+          // and we need to make sure a global search function is not applied to
+          // all tables (i.e. a range filter in a previous table should not be
+          // applied to the current table); we use the settings object to
+          // determine if we want to perform searching on the current table,
+          // since settings.sTableId will be different to different tables
+          if (table.settings()[0] !== settings) return true;
+          // no filter on this column or no need to filter this column
+          if (typeof filter === 'undefined' || !$td.data('filter')) return true;
+
+          var r = filter.val(), v, r0, r1;
+          var i_data = function(i) {
+            if (!colReorderEnabled()) return i;
+            var order = table.colReorder.order(), k;
+            for (k = 0; k < order.length; ++k) if (order[k] === i) return k;
+            return i; // in theory it will never be here...
+          }
+          v = data[i_data(i)];
+          if (type === 'number' || type === 'integer') {
+            v = parseFloat(v);
+            // how to handle NaN? currently exclude these rows
+            if (isNaN(v)) return(false);
+            r0 = parseFloat(scaleBack(r[0], scale))
+            r1 = parseFloat(scaleBack(r[1], scale));
+            if (v >= r0 && v <= r1) return true;
+          } else if (type === 'date' || type === 'time') {
+            v = new Date(v);
+            r0 = new Date(r[0] / scale); r1 = new Date(r[1] / scale);
+            if (v >= r0 && v <= r1) return true;
+          } else if (type === 'factor') {
+            if (r.length === 0 || inArray(v, r)) return true;
+          } else if (type === 'logical') {
+            if (r.length === 0) return true;
+            if (inArray(v === '' ? 'na' : v, r)) return true;
+          }
+          return false;
+        };
+
+        $.fn.dataTable.ext.search.push(customFilter);
+
+        // search for the preset search strings if it is non-empty
+        if (searchCol) $input.trigger('input').trigger('change');
+
+      });
+
+    }
+
+    // highlight search keywords
+    var highlight = function() {
+      var body = $(table.table().body());
+      // removing the old highlighting first
+      body.unhighlight();
+
+      // don't highlight the "not found" row, so we get the rows using the api
+      if (table.rows({ filter: 'applied' }).data().length === 0) return;
+      // highlight global search keywords
+      body.highlight($.trim(table.search()).split(/\s+/));
+      // then highlight keywords from individual column filters
+      if (filterRow) filterRow.each(function(i, td) {
+        var $td = $(td), type = $td.data('type');
+        if (type !== 'character') return;
+        var $input = $td.children('div').first().children('input');
+        var column = table.column(i).nodes().to$(),
+            val = $.trim($input.val());
+        if (type !== 'character' || val === '') return;
+        column.highlight(val.split(/\s+/));
+      });
+    };
+
+    if (options.searchHighlight) {
+      table
+      .on('draw.dt.dth column-visibility.dt.dth column-reorder.dt.dth', highlight)
+      .on('destroy', function() {
+        // remove event handler
+        table.off('draw.dt.dth column-visibility.dt.dth column-reorder.dt.dth');
+      });
+
+      // Set the option for escaping regex characters in our search string.  This will be used
+      // for all future matching.
+      jQuery.fn.highlight.options.escapeRegex = (!options.search || !options.search.regex);
+
+      // initial highlight for state saved conditions and initial states
+      highlight();
+    }
+
+    // run the callback function on the table instance
+    if (typeof data.callback === 'function') data.callback(table);
+
+    // double click to edit the cell, row, column, or all cells
+    if (data.editable) table.on('dblclick.dt', 'tbody td', function(e) {
+      // only bring up the editor when the cell itself is dbclicked, and ignore
+      // other dbclick events bubbled up (e.g. from the <input>)
+      if (e.target !== this) return;
+      var target = [], immediate = false;
+      switch (data.editable.target) {
+        case 'cell':
+          target = [this];
+          immediate = true;  // edit will take effect immediately
+          break;
+        case 'row':
+          target = table.cells(table.cell(this).index().row, '*').nodes();
+          break;
+        case 'column':
+          target = table.cells('*', table.cell(this).index().column).nodes();
+          break;
+        case 'all':
+          target = table.cells().nodes();
+          break;
+        default:
+          throw 'The editable parameter must be "cell", "row", "column", or "all"';
+      }
+      var disableCols = data.editable.disable ? data.editable.disable.columns : null;
+      var numericCols = data.editable.numeric;
+      var areaCols = data.editable.area;
+      var dateCols = data.editable.date;
+      for (var i = 0; i < target.length; i++) {
+        (function(cell, current) {
+          var $cell = $(cell), html = $cell.html();
+          var _cell = table.cell(cell), value = _cell.data(), index = _cell.index().column;
+          var $input;
+          if (inArray(index, numericCols)) {
+            $input = $('<input type="number">');
+          } else if (inArray(index, areaCols)) {
+            $input = $('<textarea></textarea>');
+          } else if (inArray(index, dateCols)) {
+            $input = $('<input type="date">');
+          } else {
+            $input = $('<input type="text">');
+          }
+          if (!immediate) {
+            $cell.data('input', $input).data('html', html);
+            $input.attr('title', 'Hit Ctrl+Enter to finish editing, or Esc to cancel');
+          }
+          $input.val(value);
+          if (inArray(index, disableCols)) {
+            $input.attr('readonly', '').css('filter', 'invert(25%)');
+          }
+          $cell.empty().append($input);
+          if (cell === current) $input.focus();
+          $input.css('width', '100%');
+
+          if (immediate) $input.on('blur', function(e) {
+            var valueNew = $input.val();
+            if (valueNew !== value) {
+              _cell.data(valueNew);
+              if (HTMLWidgets.shinyMode) {
+                changeInput('cell_edit', [cellInfo(cell)], 'DT.cellInfo', null, {priority: 'event'});
+              }
+              // for server-side processing, users have to call replaceData() to update the table
+              if (!server) table.draw(false);
+            } else {
+              $cell.html(html);
+            }
+          }).on('keyup', function(e) {
+            // hit Escape to cancel editing
+            if (e.keyCode === 27) $input.trigger('blur');
+          });
+
+          // bulk edit (row, column, or all)
+          if (!immediate) $input.on('keyup', function(e) {
+            var removeInput = function($cell, restore) {
+              $cell.data('input').remove();
+              if (restore) $cell.html($cell.data('html'));
+            }
+            if (e.keyCode === 27) {
+              for (var i = 0; i < target.length; i++) {
+                removeInput($(target[i]), true);
+              }
+            } else if (e.keyCode === 13 && e.ctrlKey) {
+              // Ctrl + Enter
+              var cell, $cell, _cell, cellData = [];
+              for (var i = 0; i < target.length; i++) {
+                cell = target[i]; $cell = $(cell); _cell = table.cell(cell);
+                _cell.data($cell.data('input').val());
+                HTMLWidgets.shinyMode && cellData.push(cellInfo(cell));
+                removeInput($cell, false);
+              }
+              if (HTMLWidgets.shinyMode) {
+                changeInput('cell_edit', cellData, 'DT.cellInfo', null, {priority: "event"});
+              }
+              if (!server) table.draw(false);
+            }
+          });
+        })(target[i], this);
+      }
+    });
+
+    // interaction with shiny
+    if (!HTMLWidgets.shinyMode && !crosstalkOptions.group) return;
+
+    var methods = {};
+    var shinyData = {};
+
+    methods.updateCaption = function(caption) {
+      if (!caption) return;
+      $table.children('caption').replaceWith(caption);
+    }
+
+    // register clear functions to remove input values when the table is removed
+    instance.clearInputs = {};
+
+    var changeInput = function(id, value, type, noCrosstalk, opts) {
+      var event = id;
+      id = el.id + '_' + id;
+      if (type) id = id + ':' + type;
+      // do not update if the new value is the same as old value
+      if (event !== 'cell_edit' && !/_clicked$/.test(event) && shinyData.hasOwnProperty(id) && shinyData[id] === JSON.stringify(value))
+        return;
+      shinyData[id] = JSON.stringify(value);
+      if (HTMLWidgets.shinyMode && Shiny.setInputValue) {
+        Shiny.setInputValue(id, value, opts);
+        if (!instance.clearInputs[id]) instance.clearInputs[id] = function() {
+          Shiny.setInputValue(id, null);
+        }
+      }
+
+      // HACK
+      if (event === "rows_selected" && !noCrosstalk) {
+        if (crosstalkOptions.group) {
+          var keys = crosstalkOptions.key;
+          var selectedKeys = null;
+          if (value) {
+            selectedKeys = [];
+            for (var i = 0; i < value.length; i++) {
+              // The value array's contents use 1-based row numbers, so we must
+              // convert to 0-based before indexing into the keys array.
+              selectedKeys.push(keys[value[i] - 1]);
+            }
+          }
+          instance.ctselectHandle.set(selectedKeys);
+        }
+      }
+    };
+
+    var addOne = function(x) {
+      return x.map(function(i) { return 1 + i; });
+    };
+
+    var unique = function(x) {
+      var ux = [];
+      $.each(x, function(i, el){
+        if ($.inArray(el, ux) === -1) ux.push(el);
+      });
+      return ux;
+    }
+
+    // change the row index of a cell
+    var tweakCellIndex = function(cell) {
+      var info = cell.index();
+      // some cell may not be valid. e.g, #759
+      // when using the RowGroup extension, datatables will
+      // generate the row label and the cells are not part of
+      // the data thus contain no row/col info
+      if (info === undefined)
+        return {row: null, col: null};
+      if (server) {
+        info.row = DT_rows_current[info.row];
+      } else {
+        info.row += 1;
+      }
+      return {row: info.row, col: info.column};
+    }
+
+    var cleanSelectedValues = function() {
+      changeInput('rows_selected', []);
+      changeInput('columns_selected', []);
+      changeInput('cells_selected', transposeArray2D([]), 'shiny.matrix');
+    }
+    // #828 we should clean the selection on the server-side when the table reloads
+    cleanSelectedValues();
+
+    // a flag to indicates if select extension is initialized or not
+    var flagSelectExt = table.settings()[0]._select !== undefined;
+    // the Select extension should only be used in the client mode and
+    // when the selection.mode is set to none
+    if (data.selection.mode === 'none' && !server && flagSelectExt) {
+      var updateRowsSelected = function() {
+        var rows = table.rows({selected: true});
+        var selected = [];
+        $.each(rows.indexes().toArray(), function(i, v) {
+          selected.push(v + 1);
+        });
+        changeInput('rows_selected', selected);
+      }
+      var updateColsSelected = function() {
+        var columns = table.columns({selected: true});
+        changeInput('columns_selected', columns.indexes().toArray());
+      }
+      var updateCellsSelected = function() {
+        var cells = table.cells({selected: true});
+        var selected = [];
+        cells.every(function() {
+          var row = this.index().row;
+          var col = this.index().column;
+          selected = selected.concat([[row + 1, col]]);
+        });
+        changeInput('cells_selected', transposeArray2D(selected), 'shiny.matrix');
+      }
+      table.on('select deselect', function(e, dt, type, indexes) {
+        updateRowsSelected();
+        updateColsSelected();
+        updateCellsSelected();
+      })
+      updateRowsSelected();
+      updateColsSelected();
+      updateCellsSelected();
+    }
+
+    var selMode = data.selection.mode, selTarget = data.selection.target;
+    var selDisable = data.selection.selectable === false;
+    if (inArray(selMode, ['single', 'multiple'])) {
+      var selClass = inArray(data.style, ['bootstrap', 'bootstrap4']) ? 'active' : 'selected';
+      // selected1: row indices; selected2: column indices
+      var initSel = function(x) {
+        if (x === null || typeof x === 'boolean' || selTarget === 'cell') {
+          return {rows: [], cols: []};
+        } else if (selTarget === 'row') {
+          return {rows: $.makeArray(x), cols: []};
+        } else if (selTarget === 'column') {
+          return {rows: [], cols: $.makeArray(x)};
+        } else if (selTarget === 'row+column') {
+          return {rows: $.makeArray(x.rows), cols: $.makeArray(x.cols)};
+        }
+      }
+      var selected = data.selection.selected;
+      var selected1 = initSel(selected).rows, selected2 = initSel(selected).cols;
+      // selectable should contain either all positive or all non-positive values, not both
+      // positive values indicate "selectable" while non-positive values means "nonselectable"
+      // the assertion is performed on R side. (only column indicides could be zero which indicates
+      // the row name)
+      var selectable = data.selection.selectable;
+      var selectable1 = initSel(selectable).rows, selectable2 = initSel(selectable).cols;
+
+      // After users reorder the rows or filter the table, we cannot use the table index
+      // directly. Instead, we need this function to find out the rows between the two clicks.
+      // If user filter the table again between the start click and the end click, the behavior
+      // would be undefined, but it should not be a problem.
+      var shiftSelRowsIndex = function(start, end) {
+        var indexes = server ? DT_rows_all : table.rows({ search: 'applied' }).indexes().toArray();
+        start = indexes.indexOf(start); end = indexes.indexOf(end);
+        // if start is larger than end, we need to swap
+        if (start > end) {
+          var tmp = end; end = start; start = tmp;
+        }
+        return indexes.slice(start, end + 1);
+      }
+
+      var serverRowIndex = function(clientRowIndex) {
+        return server ? DT_rows_current[clientRowIndex] : clientRowIndex + 1;
+      }
+
+      // row, column, or cell selection
+      var lastClickedRow;
+      if (inArray(selTarget, ['row', 'row+column'])) {
+        // Get the current selected rows. It will also
+        // update the selected1's value based on the current row selection state
+        // Note we can't put this function inside selectRows() directly,
+        // the reason is method.selectRows() will override selected1's value but this
+        // function will add rows to selected1 (keep the existing selection), which is
+        // inconsistent with column and cell selection.
+        var selectedRows = function() {
+          var rows = table.rows('.' + selClass);
+          var idx = rows.indexes().toArray();
+          if (!server) {
+            selected1 = addOne(idx);
+            return selected1;
+          }
+          idx = idx.map(function(i) {
+            return DT_rows_current[i];
+          });
+          selected1 = selMode === 'multiple' ? unique(selected1.concat(idx)) : idx;
+          return selected1;
+        }
+        // Change selected1's value based on selectable1, then refresh the row state
+        var onlyKeepSelectableRows = function() {
+          if (selDisable) { // users can't select; useful when only want backend select
+            selected1 = [];
+            return;
+          }
+          if (selectable1.length === 0) return;
+          var nonselectable = selectable1[0] <= 0;
+          if (nonselectable) {
+            // should make selectable1 positive
+            selected1 = $(selected1).not(selectable1.map(function(i) { return -i; })).get();
+          } else {
+            selected1 = $(selected1).filter(selectable1).get();
+          }
+        }
+        // Change selected1's value based on selectable1, then
+        // refresh the row selection state according to values in selected1
+        var selectRows = function(ignoreSelectable) {
+          if (!ignoreSelectable) onlyKeepSelectableRows();
+          table.$('tr.' + selClass).removeClass(selClass);
+          if (selected1.length === 0) return;
+          if (server) {
+            table.rows({page: 'current'}).every(function() {
+              if (inArray(DT_rows_current[this.index()], selected1)) {
+                $(this.node()).addClass(selClass);
+              }
+            });
+          } else {
+            var selected0 = selected1.map(function(i) { return i - 1; });
+            $(table.rows(selected0).nodes()).addClass(selClass);
+          }
+        }
+        table.on('mousedown.dt', 'tbody tr', function(e) {
+          var $this = $(this), thisRow = table.row(this);
+          if (selMode === 'multiple') {
+            if (e.shiftKey && lastClickedRow !== undefined) {
+              // select or de-select depends on the last clicked row's status
+              var flagSel = !$this.hasClass(selClass);
+              var crtClickedRow = serverRowIndex(thisRow.index());
+              if (server) {
+                var rowsIndex = shiftSelRowsIndex(lastClickedRow, crtClickedRow);
+                // update current page's selClass
+                rowsIndex.map(function(i) {
+                  var rowIndex = DT_rows_current.indexOf(i);
+                  if (rowIndex >= 0) {
+                    var row = table.row(rowIndex).nodes().to$();
+                    var flagRowSel = !row.hasClass(selClass);
+                    if (flagSel === flagRowSel) row.toggleClass(selClass);
+                  }
+                });
+                // update selected1
+                if (flagSel) {
+                  selected1 = unique(selected1.concat(rowsIndex));
+                } else {
+                  selected1 = selected1.filter(function(index) {
+                    return !inArray(index, rowsIndex);
+                  });
+                }
+              } else {
+                // js starts from 0
+                shiftSelRowsIndex(lastClickedRow - 1, crtClickedRow - 1).map(function(value) {
+                  var row = table.row(value).nodes().to$();
+                  var flagRowSel = !row.hasClass(selClass);
+                  if (flagSel === flagRowSel) row.toggleClass(selClass);
+                });
+              }
+              e.preventDefault();
+            } else {
+              $this.toggleClass(selClass);
+            }
+          } else {
+            if ($this.hasClass(selClass)) {
+              $this.removeClass(selClass);
+            } else {
+              table.$('tr.' + selClass).removeClass(selClass);
+              $this.addClass(selClass);
+            }
+          }
+          if (server && !$this.hasClass(selClass)) {
+            var id = DT_rows_current[thisRow.index()];
+            // remove id from selected1 since its class .selected has been removed
+            if (inArray(id, selected1)) selected1.splice($.inArray(id, selected1), 1);
+          }
+          selectedRows(); // update selected1's value based on selClass
+          selectRows(false); // only keep the selectable rows
+          changeInput('rows_selected', selected1);
+          changeInput('row_last_clicked', serverRowIndex(thisRow.index()), null, null, {priority: 'event'});
+          lastClickedRow = serverRowIndex(thisRow.index());
+        });
+        selectRows(false);  // in case users have specified pre-selected rows
+        // restore selected rows after the table is redrawn (e.g. sort/search/page);
+        // client-side tables will preserve the selections automatically; for
+        // server-side tables, we have to *real* row indices are in `selected1`
+        changeInput('rows_selected', selected1);
+        if (server) table.on('draw.dt', function(e) { selectRows(false); });
+        methods.selectRows = function(selected, ignoreSelectable) {
+          selected1 = $.makeArray(selected);
+          selectRows(ignoreSelectable);
+          changeInput('rows_selected', selected1);
+        }
+      }
+
+      if (inArray(selTarget, ['column', 'row+column'])) {
+        if (selTarget === 'row+column') {
+          $(table.columns().footer()).css('cursor', 'pointer');
+        }
+        // update selected2's value based on selectable2
+        var onlyKeepSelectableCols = function() {
+          if (selDisable) { // users can't select; useful when only want backend select
+            selected2 = [];
+            return;
+          }
+          if (selectable2.length === 0) return;
+          var nonselectable = selectable2[0] <= 0;
+          if (nonselectable) {
+            // need to make selectable2 positive
+            selected2 = $(selected2).not(selectable2.map(function(i) { return -i; })).get();
+          } else {
+            selected2 = $(selected2).filter(selectable2).get();
+          }
+        }
+        // update selected2 and then
+        // refresh the col selection state according to values in selected2
+        var selectCols = function(ignoreSelectable) {
+          if (!ignoreSelectable) onlyKeepSelectableCols();
+          // if selected2 is not a valide index (e.g., larger than the column number)
+          // table.columns(selected2) will fail and result in a blank table
+          // this is different from the table.rows(), where the out-of-range indexes
+          // doesn't affect at all
+          selected2 = $(selected2).filter(table.columns().indexes()).get();
+          table.columns().nodes().flatten().to$().removeClass(selClass);
+          if (selected2.length > 0)
+            table.columns(selected2).nodes().flatten().to$().addClass(selClass);
+        }
+        var callback = function() {
+          var colIdx = selTarget === 'column' ? table.cell(this).index().column :
+              $.inArray(this, table.columns().footer()),
+              thisCol = $(table.column(colIdx).nodes());
+          if (colIdx === -1) return;
+          if (thisCol.hasClass(selClass)) {
+            thisCol.removeClass(selClass);
+            selected2.splice($.inArray(colIdx, selected2), 1);
+          } else {
+            if (selMode === 'single') $(table.cells().nodes()).removeClass(selClass);
+            thisCol.addClass(selClass);
+            selected2 = selMode === 'single' ? [colIdx] : unique(selected2.concat([colIdx]));
+          }
+          selectCols(false); // update selected2 based on selectable
+          changeInput('columns_selected', selected2);
+        }
+        if (selTarget === 'column') {
+          $(table.table().body()).on('click.dt', 'td', callback);
+        } else {
+          $(table.table().footer()).on('click.dt', 'tr th', callback);
+        }
+        selectCols(false);  // in case users have specified pre-selected columns
+        changeInput('columns_selected', selected2);
+        if (server) table.on('draw.dt', function(e) { selectCols(false); });
+        methods.selectColumns = function(selected, ignoreSelectable) {
+          selected2 = $.makeArray(selected);
+          selectCols(ignoreSelectable);
+          changeInput('columns_selected', selected2);
+        }
+      }
+
+      if (selTarget === 'cell') {
+        var selected3 = [], selectable3 = [];
+        if (selected !== null) selected3 = selected;
+        if (selectable !== null && typeof selectable !== 'boolean') selectable3 = selectable;
+        var findIndex = function(ij, sel) {
+          for (var i = 0; i < sel.length; i++) {
+            if (ij[0] === sel[i][0] && ij[1] === sel[i][1]) return i;
+          }
+          return -1;
+        }
+         // Change selected3's value based on selectable3, then refresh the cell state
+        var onlyKeepSelectableCells = function() {
+          if (selDisable) { // users can't select; useful when only want backend select
+            selected3 = [];
+            return;
+          }
+          if (selectable3.length === 0) return;
+          var nonselectable = selectable3[0][0] <= 0;
+          var out = [];
+          if (nonselectable) {
+            selected3.map(function(ij) {
+              // should make selectable3 positive
+              if (findIndex([-ij[0], -ij[1]], selectable3) === -1) { out.push(ij); }
+            });
+          } else {
+            selected3.map(function(ij) {
+              if (findIndex(ij, selectable3) > -1) { out.push(ij); }
+            });
+          }
+          selected3 = out;
+        }
+        // Change selected3's value based on selectable3, then
+        // refresh the cell selection state according to values in selected3
+        var selectCells = function(ignoreSelectable) {
+          if (!ignoreSelectable) onlyKeepSelectableCells();
+          table.$('td.' + selClass).removeClass(selClass);
+          if (selected3.length === 0) return;
+          if (server) {
+            table.cells({page: 'current'}).every(function() {
+              var info = tweakCellIndex(this);
+              if (findIndex([info.row, info.col], selected3) > -1)
+                $(this.node()).addClass(selClass);
+            });
+          } else {
+            selected3.map(function(ij) {
+              $(table.cell(ij[0] - 1, ij[1]).node()).addClass(selClass);
+            });
+          }
+        };
+        table.on('click.dt', 'tbody td', function() {
+          var $this = $(this), info = tweakCellIndex(table.cell(this));
+          if ($this.hasClass(selClass)) {
+            $this.removeClass(selClass);
+            selected3.splice(findIndex([info.row, info.col], selected3), 1);
+          } else {
+            if (selMode === 'single') $(table.cells().nodes()).removeClass(selClass);
+            $this.addClass(selClass);
+            selected3 = selMode === 'single' ? [[info.row, info.col]] :
+              unique(selected3.concat([[info.row, info.col]]));
+          }
+          selectCells(false); // must call this to update selected3 based on selectable3
+          changeInput('cells_selected', transposeArray2D(selected3), 'shiny.matrix');
+        });
+        selectCells(false);  // in case users have specified pre-selected columns
+        changeInput('cells_selected', transposeArray2D(selected3), 'shiny.matrix');
+
+        if (server) table.on('draw.dt', function(e) { selectCells(false); });
+        methods.selectCells = function(selected, ignoreSelectable) {
+          selected3 = selected ? selected : [];
+          selectCells(ignoreSelectable);
+          changeInput('cells_selected', transposeArray2D(selected3), 'shiny.matrix');
+        }
+      }
+    }
+
+    // expose some table info to Shiny
+    var updateTableInfo = function(e, settings) {
+      // TODO: is anyone interested in the page info?
+      // changeInput('page_info', table.page.info());
+      var updateRowInfo = function(id, modifier) {
+        var idx;
+        if (server) {
+          idx = modifier.page === 'current' ? DT_rows_current : DT_rows_all;
+        } else {
+          var rows = table.rows($.extend({
+            search: 'applied',
+            page: 'all'
+          }, modifier));
+          idx = addOne(rows.indexes().toArray());
+        }
+        changeInput('rows' + '_' + id, idx);
+      };
+      updateRowInfo('current', {page: 'current'});
+      updateRowInfo('all', {});
+    }
+    table.on('draw.dt', updateTableInfo);
+    updateTableInfo();
+
+    // state info
+    table.on('draw.dt column-visibility.dt', function() {
+      changeInput('state', table.state());
+    });
+    changeInput('state', table.state());
+
+    // search info
+    var updateSearchInfo = function() {
+      changeInput('search', table.search());
+      if (filterRow) changeInput('search_columns', filterRow.toArray().map(function(td) {
+        return $(td).find('input').first().val();
+      }));
+    }
+    table.on('draw.dt', updateSearchInfo);
+    updateSearchInfo();
+
+    var cellInfo = function(thiz) {
+      var info = tweakCellIndex(table.cell(thiz));
+      info.value = table.cell(thiz).data();
+      return info;
+    }
+    // the current cell clicked on
+    table.on('click.dt', 'tbody td', function() {
+      changeInput('cell_clicked', cellInfo(this), null, null, {priority: 'event'});
+    })
+    changeInput('cell_clicked', {});
+
+    // do not trigger table selection when clicking on links unless they have classes
+    table.on('mousedown.dt', 'tbody td a', function(e) {
+      if (this.className === '') e.stopPropagation();
+    });
+
+    methods.addRow = function(data, rowname, resetPaging) {
+      var n = table.columns().indexes().length, d = n - data.length;
+      if (d === 1) {
+        data = rowname.concat(data)
+      } else if (d !== 0) {
+        console.log(data);
+        console.log(table.columns().indexes());
+        throw 'New data must be of the same length as current data (' + n + ')';
+      };
+      table.row.add(data).draw(resetPaging);
+    }
+
+    methods.updateSearch = function(keywords) {
+      if (keywords.global !== null)
+        $(table.table().container()).find('input[type=search]').first()
+             .val(keywords.global).trigger('input');
+      var columns = keywords.columns;
+      if (!filterRow || columns === null) return;
+      filterRow.toArray().map(function(td, i) {
+        var v = typeof columns === 'string' ? columns : columns[i];
+        if (typeof v === 'undefined') {
+          console.log('The search keyword for column ' + i + ' is undefined')
+          return;
+        }
+        // Update column search string and values on linked filter widgets.
+        // 'input' for factor and char filters, 'change' for numeric filters.
+        $(td).find('input').first().val(v).trigger('input', [true]).trigger('change');
+      });
+      table.draw();
+    }
+
+    methods.hideCols = function(hide, reset) {
+      if (reset) table.columns().visible(true, false);
+      table.columns(hide).visible(false);
+    }
+
+    methods.showCols = function(show, reset) {
+      if (reset) table.columns().visible(false, false);
+      table.columns(show).visible(true);
+    }
+
+    methods.colReorder = function(order, origOrder) {
+      table.colReorder.order(order, origOrder);
+    }
+
+    methods.selectPage = function(page) {
+      if (table.page.info().pages < page || page < 1) {
+        throw 'Selected page is out of range';
+      };
+      table.page(page - 1).draw(false);
+    }
+
+    methods.reloadData = function(resetPaging, clearSelection) {
+      // empty selections first if necessary
+      if (methods.selectRows && inArray('row', clearSelection)) methods.selectRows([]);
+      if (methods.selectColumns && inArray('column', clearSelection)) methods.selectColumns([]);
+      if (methods.selectCells && inArray('cell', clearSelection)) methods.selectCells([]);
+      table.ajax.reload(null, resetPaging);
+    }
+
+    // update table filters (set new limits of sliders)
+    methods.updateFilters = function(newProps) {
+      // loop through each filter in the filter row
+      filterRow.each(function(i, td) {
+        var k = i;
+        if (filterRow.length > newProps.length) {
+          if (i === 0) return;  // first column is row names
+          k = i - 1;
+        }
+        // Update the filters to reflect the updated data.
+        // Allow "falsy" (e.g. NULL) to signify a no-op.
+        if (newProps[k]) {
+          setFilterProps(td, newProps[k]);
+        }
+      });
+    };
+
+    table.shinyMethods = methods;
+  },
+  resize: function(el, width, height, instance) {
+    if (instance.data) this.renderValue(el, instance.data, instance);
+
+    // dynamically adjust height if fillContainer = TRUE
+    if (instance.fillContainer)
+      this.fillAvailableHeight(el, height);
+
+    this.adjustWidth(el);
+  },
+
+  // dynamically set the scroll body to fill available height
+  // (used with fillContainer = TRUE)
+  fillAvailableHeight: function(el, availableHeight) {
+
+    // see how much of the table is occupied by header/footer elements
+    // and use that to compute a target scroll body height
+    var dtWrapper = $(el).find('div.dataTables_wrapper');
+    var dtScrollBody = $(el).find($('div.dataTables_scrollBody'));
+    var framingHeight = dtWrapper.innerHeight() - dtScrollBody.innerHeight();
+    var scrollBodyHeight = availableHeight - framingHeight;
+
+    // we need to set `max-height` to none as datatables library now sets this
+    // to a fixed height, disabling the ability to resize to fill the window,
+    // as it will be set to a fixed 100px under such circumstances, e.g., RStudio IDE,
+    // or FlexDashboard
+    // see https://github.com/rstudio/DT/issues/951#issuecomment-1026464509
+    dtScrollBody.css('max-height', 'none');
+    // set the height
+    dtScrollBody.height(scrollBodyHeight + 'px');
+  },
+
+  // adjust the width of columns; remove the hard-coded widths on table and the
+  // scroll header when scrollX/Y are enabled
+  adjustWidth: function(el) {
+    var $el = $(el), table = $el.data('datatable');
+    if (table) table.columns.adjust();
+    $el.find('.dataTables_scrollHeadInner').css('width', '')
+        .children('table').css('margin-left', '');
+  }
+});
+
+  if (!HTMLWidgets.shinyMode) return;
+
+  Shiny.addCustomMessageHandler('datatable-calls', function(data) {
+    var id = data.id;
+    var el = document.getElementById(id);
+    var table = el ? $(el).data('datatable') : null;
+    if (!table) {
+      console.log("Couldn't find table with id " + id);
+      return;
+    }
+
+    var methods = table.shinyMethods, call = data.call;
+    if (methods[call.method]) {
+      methods[call.method].apply(table, call.args);
+    } else {
+      console.log("Unknown method " + call.method);
+    }
+  });
+
+})();
diff --git a/docs/articles/S2_EDA_files/dt-core-1.13.6/css/jquery.dataTables.extra.css b/docs/articles/S2_EDA_files/dt-core-1.13.6/css/jquery.dataTables.extra.css
new file mode 100644
index 0000000..b2dd141
--- /dev/null
+++ b/docs/articles/S2_EDA_files/dt-core-1.13.6/css/jquery.dataTables.extra.css
@@ -0,0 +1,28 @@
+/* Selected rows/cells */
+table.dataTable tr.selected td, table.dataTable td.selected {
+  background-color: #b0bed9 !important;
+}
+/* In case of scrollX/Y or FixedHeader */
+.dataTables_scrollBody .dataTables_sizing {
+  visibility: hidden;
+}
+
+/* The datatables' theme CSS file doesn't define
+the color but with white background. It leads to an issue that
+when the HTML's body color is set to 'white', the user can't
+see the text since the background is white. One case happens in the
+RStudio's IDE when inline viewing the DT table inside an Rmd file,
+if the IDE theme is set to "Cobalt".
+
+See https://github.com/rstudio/DT/issues/447 for more info
+
+This fixes should have little side-effects because all the other elements
+of the default theme use the #333 font color.
+
+TODO: The upstream may use relative colors for both the table background
+and the color. It means the table can display well without this patch
+then. At that time, we need to remove the below CSS attributes.
+*/
+div.datatables {
+  color: #333;
+}
diff --git a/docs/articles/S2_EDA_files/dt-core-1.13.6/css/jquery.dataTables.min.css b/docs/articles/S2_EDA_files/dt-core-1.13.6/css/jquery.dataTables.min.css
new file mode 100644
index 0000000..ad59f84
--- /dev/null
+++ b/docs/articles/S2_EDA_files/dt-core-1.13.6/css/jquery.dataTables.min.css
@@ -0,0 +1 @@
+:root{--dt-row-selected: 13, 110, 253;--dt-row-selected-text: 255, 255, 255;--dt-row-selected-link: 9, 10, 11;--dt-row-stripe: 0, 0, 0;--dt-row-hover: 0, 0, 0;--dt-column-ordering: 0, 0, 0;--dt-html-background: white}:root.dark{--dt-html-background: rgb(33, 37, 41)}table.dataTable td.dt-control{text-align:center;cursor:pointer}table.dataTable td.dt-control:before{display:inline-block;color:rgba(0, 0, 0, 0.5);content:"►"}table.dataTable tr.dt-hasChild td.dt-control:before{content:"▼"}html.dark table.dataTable td.dt-control:before{color:rgba(255, 255, 255, 0.5)}html.dark table.dataTable tr.dt-hasChild td.dt-control:before{color:rgba(255, 255, 255, 0.5)}table.dataTable thead>tr>th.sorting,table.dataTable thead>tr>th.sorting_asc,table.dataTable thead>tr>th.sorting_desc,table.dataTable thead>tr>th.sorting_asc_disabled,table.dataTable thead>tr>th.sorting_desc_disabled,table.dataTable thead>tr>td.sorting,table.dataTable thead>tr>td.sorting_asc,table.dataTable 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thead>tr>td.sorting_asc_disabled:before,table.dataTable thead>tr>td.sorting_asc_disabled:after,table.dataTable thead>tr>td.sorting_desc_disabled:before,table.dataTable thead>tr>td.sorting_desc_disabled:after{position:absolute;display:block;opacity:.125;right:10px;line-height:9px;font-size:.8em}table.dataTable thead>tr>th.sorting:before,table.dataTable thead>tr>th.sorting_asc:before,table.dataTable thead>tr>th.sorting_desc:before,table.dataTable thead>tr>th.sorting_asc_disabled:before,table.dataTable thead>tr>th.sorting_desc_disabled:before,table.dataTable thead>tr>td.sorting:before,table.dataTable thead>tr>td.sorting_asc:before,table.dataTable thead>tr>td.sorting_desc:before,table.dataTable thead>tr>td.sorting_asc_disabled:before,table.dataTable thead>tr>td.sorting_desc_disabled:before{bottom:50%;content:"▲";content:"▲"/""}table.dataTable thead>tr>th.sorting:after,table.dataTable thead>tr>th.sorting_asc:after,table.dataTable thead>tr>th.sorting_desc:after,table.dataTable thead>tr>th.sorting_asc_disabled:after,table.dataTable thead>tr>th.sorting_desc_disabled:after,table.dataTable thead>tr>td.sorting:after,table.dataTable thead>tr>td.sorting_asc:after,table.dataTable thead>tr>td.sorting_desc:after,table.dataTable thead>tr>td.sorting_asc_disabled:after,table.dataTable thead>tr>td.sorting_desc_disabled:after{top:50%;content:"▼";content:"▼"/""}table.dataTable thead>tr>th.sorting_asc:before,table.dataTable thead>tr>th.sorting_desc:after,table.dataTable thead>tr>td.sorting_asc:before,table.dataTable thead>tr>td.sorting_desc:after{opacity:.6}table.dataTable thead>tr>th.sorting_desc_disabled:after,table.dataTable thead>tr>th.sorting_asc_disabled:before,table.dataTable thead>tr>td.sorting_desc_disabled:after,table.dataTable thead>tr>td.sorting_asc_disabled:before{display:none}table.dataTable thead>tr>th:active,table.dataTable 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new file mode 100644
index 0000000..f786b0d
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paging_",sLength:"dataTables_length",sProcessing:"dataTables_processing",sSortAsc:"sorting_asc",sSortDesc:"sorting_desc",sSortable:"sorting",sSortableAsc:"sorting_desc_disabled",sSortableDesc:"sorting_asc_disabled",sSortableNone:"sorting_disabled",sSortColumn:"sorting_",sFilterInput:"",sLengthSelect:"",sScrollWrapper:"dataTables_scroll",sScrollHead:"dataTables_scrollHead",sScrollHeadInner:"dataTables_scrollHeadInner",sScrollBody:"dataTables_scrollBody",sScrollFoot:"dataTables_scrollFoot",sScrollFootInner:"dataTables_scrollFootInner",sHeaderTH:"",sFooterTH:"",sSortJUIAsc:"",sSortJUIDesc:"",sSortJUI:"",sSortJUIAscAllowed:"",sSortJUIDescAllowed:"",sSortJUIWrapper:"",sSortIcon:"",sJUIHeader:"",sJUIFooter:""}),w.ext.pager);function Oe(t,e){var n=[],a=Ne.numbers_length,r=Math.floor(a/2);return e<=a?n=f(0,e):t<=r?((n=f(0,a-2)).push("ellipsis"),n.push(e-1)):((e-1-r<=t?n=f(e-(a-2),e):((n=f(t-r+2,t+r-1)).push("ellipsis"),n.push(e-1),n)).splice(0,0,"ellipsis"),n.splice(0,0,0)),n.DT_el="span",n}P.extend(Ne,{simple:function(t,e){return["previous","next"]},full:function(t,e){return["first","previous","next","last"]},numbers:function(t,e){return[Oe(t,e)]},simple_numbers:function(t,e){return["previous",Oe(t,e),"next"]},full_numbers:function(t,e){return["first","previous",Oe(t,e),"next","last"]},first_last_numbers:function(t,e){return["first",Oe(t,e),"last"]},_numbers:Oe,numbers_length:7}),P.extend(!0,w.ext.renderer,{pageButton:{_:function(u,t,c,e,f,d){function h(t,e){for(var n,a=b.sPageButtonDisabled,r=function(t){Yt(u,t.data.action,!0)},o=0,i=e.length;o<i;o++)if(n=e[o],Array.isArray(n)){var l=P("<"+(n.DT_el||"div")+"/>").appendTo(t);h(l,n)}else{var s=!1;switch(p=null,g=n){case"ellipsis":t.append('<span 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ke(t,n,V,q)}},function(t,e){p.type.order[t+n+"-pre"]=e,t.match(/^html\-/)&&(p.type.search[t+n]=p.type.search.html)})}P.extend(p.type.order,{"date-pre":function(t){t=Date.parse(t);return isNaN(t)?-1/0:t},"html-pre":function(t){return h(t)?"":t.replace?t.replace(/<.*?>/g,"").toLowerCase():t+""},"string-pre":function(t){return h(t)?"":"string"==typeof t?t.toLowerCase():t.toString?t.toString():""},"string-asc":function(t,e){return t<e?-1:e<t?1:0},"string-desc":function(t,e){return t<e?1:e<t?-1:0}}),Me(""),P.extend(!0,w.ext.renderer,{header:{_:function(r,o,i,l){P(r.nTable).on("order.dt.DT",function(t,e,n,a){r===e&&(e=i.idx,o.removeClass(l.sSortAsc+" "+l.sSortDesc).addClass("asc"==a[e]?l.sSortAsc:"desc"==a[e]?l.sSortDesc:i.sSortingClass))})},jqueryui:function(r,o,i,l){P("<div/>").addClass(l.sSortJUIWrapper).append(o.contents()).append(P("<span/>").addClass(l.sSortIcon+" 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diff --git a/docs/articles/S2_EDA_files/figure-html/doansc-1.png b/docs/articles/S2_EDA_files/figure-html/doansc-1.png
index 2525d64..887b85c 100644
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diff --git a/docs/articles/S2_EDA_files/figure-html/dobiv-1.png b/docs/articles/S2_EDA_files/figure-html/dobiv-1.png
index da0a0e9..e15207c 100644
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diff --git a/docs/articles/S2_EDA_files/figure-html/doboco-1.png b/docs/articles/S2_EDA_files/figure-html/doboco-1.png
index 92c0aa1..e4e170e 100644
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diff --git a/docs/articles/S2_EDA_files/figure-html/doboxc-1.png b/docs/articles/S2_EDA_files/figure-html/doboxc-1.png
index 6f1b1f5..e460fbd 100644
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diff --git a/docs/articles/S2_EDA_files/figure-html/lkda-1.png b/docs/articles/S2_EDA_files/figure-html/lkda-1.png
index 8840d7d..5e39d49 100644
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diff --git a/docs/articles/S2_EDA_files/figure-html/lkqqp-1.png b/docs/articles/S2_EDA_files/figure-html/lkqqp-1.png
index f24df40..b023639 100644
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diff --git a/docs/articles/S2_EDA_files/figure-html/lksmoo-1.png b/docs/articles/S2_EDA_files/figure-html/lksmoo-1.png
index d344d1a..7673d3d 100644
Binary files a/docs/articles/S2_EDA_files/figure-html/lksmoo-1.png and b/docs/articles/S2_EDA_files/figure-html/lksmoo-1.png differ
diff --git a/docs/articles/S2_EDA_files/htmltools-fill-0.5.8.1/fill.css b/docs/articles/S2_EDA_files/htmltools-fill-0.5.8.1/fill.css
new file mode 100644
index 0000000..841ea9d
--- /dev/null
+++ b/docs/articles/S2_EDA_files/htmltools-fill-0.5.8.1/fill.css
@@ -0,0 +1,21 @@
+@layer htmltools {
+  .html-fill-container {
+    display: flex;
+    flex-direction: column;
+    /* Prevent the container from expanding vertically or horizontally beyond its
+    parent's constraints. */
+    min-height: 0;
+    min-width: 0;
+  }
+  .html-fill-container > .html-fill-item {
+    /* Fill items can grow and shrink freely within
+    available vertical space in fillable container */
+    flex: 1 1 auto;
+    min-height: 0;
+    min-width: 0;
+  }
+  .html-fill-container > :not(.html-fill-item) {
+    /* Prevent shrinking or growing of non-fill items */
+    flex: 0 0 auto;
+  }
+}
diff --git a/docs/articles/S2_EDA_files/htmlwidgets-1.6.4/htmlwidgets.js b/docs/articles/S2_EDA_files/htmlwidgets-1.6.4/htmlwidgets.js
new file mode 100644
index 0000000..1067d02
--- /dev/null
+++ b/docs/articles/S2_EDA_files/htmlwidgets-1.6.4/htmlwidgets.js
@@ -0,0 +1,901 @@
+(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
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-      <img src="" class="logo" alt=""><h1>S2a: Elements of PCA</h1>
+
+      <h1>S2a: Elements of PCA</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S2a_PCAelem.Rmd" class="external-link"><code>vignettes/S2a_PCAelem.Rmd</code></a></small>
       <div class="d-none name"><code>S2a_PCAelem.Rmd</code></div>
@@ -128,7 +118,7 @@ <h2 id="make-a-bivariate-dataset-with-positive-correlation-and-heterogeneous-var
 <span><span class="fu"><a href="https://rdrr.io/r/graphics/plot.default.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">prc</span><span class="op">$</span><span class="va">x</span>, xlim<span class="op">=</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="op">-</span><span class="fl">10</span>,<span class="fl">10</span><span class="op">)</span>, ylim<span class="op">=</span><span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="op">-</span><span class="fl">10</span>,<span class="fl">10</span><span class="op">)</span><span class="op">)</span></span></code></pre></div>
 <p><img src="S2a_PCAelem_files/figure-html/lk4-1.png" width="700"></p>
 <p>PC1 is produced by taking <em>linear combinations</em> of the rows of sim1.</p>
-<p>We’ll illustrate the linear combination concept. The data vector for the first row may be written <span class="math inline">\((x_1, x_2)\)</span>, and a linear combination has the form <span class="math inline">\(ax_1 + bx_2\)</span> for some coefficients <span class="math inline">\(a\)</span> and <span class="math inline">\(b\)</span>.</p>
+<p>We’ll illustrate the linear combination concept. The data vector for the first row may be written <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mo stretchy="true" form="prefix">(</mo><msub><mi>x</mi><mn>1</mn></msub><mo>,</mo><msub><mi>x</mi><mn>2</mn></msub><mo stretchy="true" form="postfix">)</mo></mrow><annotation encoding="application/x-tex">(x_1, x_2)</annotation></semantics></math>, and a linear combination has the form <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>a</mi><msub><mi>x</mi><mn>1</mn></msub><mo>+</mo><mi>b</mi><msub><mi>x</mi><mn>2</mn></msub></mrow><annotation encoding="application/x-tex">ax_1 + bx_2</annotation></semantics></math> for some coefficients <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mi>a</mi><annotation encoding="application/x-tex">a</annotation></semantics></math> and <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mi>b</mi><annotation encoding="application/x-tex">b</annotation></semantics></math>.</p>
 <p>The coefficients are derived from the rotation component of the PCA.</p>
 <div class="sourceCode" id="cb9"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">prc</span><span class="op">$</span><span class="va">rotation</span></span></code></pre></div>
@@ -184,7 +174,7 @@ <h2 id="make-a-bivariate-dataset-with-positive-correlation-and-heterogeneous-var
 <span>  main<span class="op">=</span><span class="st">"data %*% rot %*% t(rot)"</span>, xlab<span class="op">=</span><span class="st">"data %*% VVt (col 1)"</span>,</span>
 <span>  ylab <span class="op">=</span> <span class="st">"data %*% VVt (col 2)"</span><span class="op">)</span></span></code></pre></div>
 <p><img src="S2a_PCAelem_files/figure-html/lkm-1.png" width="700"></p>
-<p>The rotation has been “undone”. Letting <span class="math inline">\(V\)</span> denote the ‘rotation’ component of the PCA, this shows that the matrix product <span class="math inline">\(VV^t = I\)</span>, where <span class="math inline">\(I\)</span> is a diagonal matrix with 1 on the diagonal. More background on the underlying computations can be gleaned from the <a href="https://en.wikipedia.org/wiki/Singular_value_decomposition" class="external-link">Wikipedia entry on singular value decomposition</a>.</p>
+<p>The rotation has been “undone”. Letting <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mi>V</mi><annotation encoding="application/x-tex">V</annotation></semantics></math> denote the ‘rotation’ component of the PCA, this shows that the matrix product <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>V</mi><msup><mi>V</mi><mi>t</mi></msup><mo>=</mo><mi>I</mi></mrow><annotation encoding="application/x-tex">VV^t = I</annotation></semantics></math>, where <math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mi>I</mi><annotation encoding="application/x-tex">I</annotation></semantics></math> is a diagonal matrix with 1 on the diagonal. More background on the underlying computations can be gleaned from the <a href="https://en.wikipedia.org/wiki/Singular_value_decomposition" class="external-link">Wikipedia entry on singular value decomposition</a>.</p>
 </div>
 <div class="section level2">
 <h2 id="a-larger-covariance-matrix">A larger covariance matrix<a class="anchor" aria-label="anchor" href="#a-larger-covariance-matrix"></a>
@@ -207,20 +197,20 @@ <h2 id="a-larger-covariance-matrix">A larger covariance matrix<a class="anchor"
 <p>We verify the multivariate structure:</p>
 <div class="sourceCode" id="cb24"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/cor.html" class="external-link">cor</a></span><span class="op">(</span><span class="va">myd</span><span class="op">)</span></span></code></pre></div>
-<pre><code><span><span class="co">##         [,1]     [,2]     [,3]     [,4]    [,5]</span></span>
-<span><span class="co">## [1,]  1.0000 -0.61123  0.00340 -0.01582  0.0489</span></span>
-<span><span class="co">## [2,] -0.6112  1.00000  0.00182 -0.00636 -0.0348</span></span>
-<span><span class="co">## [3,]  0.0034  0.00182  1.00000  0.79564 -0.0380</span></span>
-<span><span class="co">## [4,] -0.0158 -0.00636  0.79564  1.00000 -0.0276</span></span>
-<span><span class="co">## [5,]  0.0489 -0.03478 -0.03797 -0.02760  1.0000</span></span></code></pre>
+<pre><code><span><span class="co">##          [,1]     [,2]     [,3]     [,4]    [,5]</span></span>
+<span><span class="co">## [1,]  1.00000 -0.61123 -0.00337  0.01546  0.0489</span></span>
+<span><span class="co">## [2,] -0.61123  1.00000 -0.00105  0.00686 -0.0348</span></span>
+<span><span class="co">## [3,] -0.00337 -0.00105  1.00000  0.80438 -0.0361</span></span>
+<span><span class="co">## [4,]  0.01546  0.00686  0.80438  1.00000 -0.0365</span></span>
+<span><span class="co">## [5,]  0.04888 -0.03478 -0.03611 -0.03648  1.0000</span></span></code></pre>
 <div class="sourceCode" id="cb26"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/stats/cor.html" class="external-link">cov</a></span><span class="op">(</span><span class="va">myd</span><span class="op">)</span></span></code></pre></div>
-<pre><code><span><span class="co">##         [,1]    [,2]    [,3]    [,4]    [,5]</span></span>
-<span><span class="co">## [1,]  4.1482 -3.8816  0.0138 -0.0316  0.0986</span></span>
-<span><span class="co">## [2,] -3.8816  9.7217  0.0113 -0.0195 -0.1075</span></span>
-<span><span class="co">## [3,]  0.0138  0.0113  3.9702  1.5539 -0.0750</span></span>
-<span><span class="co">## [4,] -0.0316 -0.0195  1.5539  0.9607 -0.0268</span></span>
-<span><span class="co">## [5,]  0.0986 -0.1075 -0.0750 -0.0268  0.9816</span></span></code></pre>
+<pre><code><span><span class="co">##         [,1]     [,2]     [,3]    [,4]    [,5]</span></span>
+<span><span class="co">## [1,]  4.1482 -3.88159 -0.01360  0.0317  0.0986</span></span>
+<span><span class="co">## [2,] -3.8816  9.72168 -0.00648  0.0215 -0.1075</span></span>
+<span><span class="co">## [3,] -0.0136 -0.00648  3.91911  1.6017 -0.0708</span></span>
+<span><span class="co">## [4,]  0.0317  0.02153  1.60174  1.0118 -0.0364</span></span>
+<span><span class="co">## [5,]  0.0986 -0.10745 -0.07082 -0.0364  0.9816</span></span></code></pre>
 <div class="sourceCode" id="cb28"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/dim.html" class="external-link">dim</a></span><span class="op">(</span><span class="va">myd</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## [1] 2000    5</span></span></code></pre>
@@ -246,28 +236,26 @@ <h2 id="eigengenes-derived-from-pca">“Eigengenes” derived from PCA<a class="
 </ul>
 <p>Note that the simple reconstructions above have required that prcomp be used with center=FALSE.</p>
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-      <img src="" class="logo" alt=""><h1>S3: Distances, clustering</h1>
+
+      <h1>S3: Distances, clustering</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S3_distclust.Rmd" class="external-link"><code>vignettes/S3_distclust.Rmd</code></a></small>
       <div class="d-none name"><code>S3_distclust.Rmd</code></div>
@@ -130,10 +120,10 @@ <h2 id="application-inferring-steps-in-tumor-metastasis-in-a-breast-cancer-patie
 </h2>
 <p>We’ll examine data distributed with a <a href="https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-021-00989-6" class="external-link">2021 Genome Biology paper</a> from the Gabor Marth lab.</p>
 <div class="figure">
-<img src="marthPatient.jpg" alt="Clinical sequence of interventions."><p class="caption">Clinical sequence of interventions.</p>
+<img src="marthPatient.jpg" alt=""><p class="caption">Clinical sequence of interventions.</p>
 </div>
 <div class="figure">
-<img src="marthEvolve.jpg" alt="Event sequence."><p class="caption">Event sequence.</p>
+<img src="marthEvolve.jpg" alt=""><p class="caption">Event sequence.</p>
 </div>
 <div class="section level3">
 <h3 id="a-view-of-copy-number-aberrations-for-1mb-tiling">A view of copy number aberrations for 1Mb tiling<a class="anchor" aria-label="anchor" href="#a-view-of-copy-number-aberrations-for-1mb-tiling"></a>
@@ -267,28 +257,26 @@ <h4 id="exercises">Exercises<a class="anchor" aria-label="anchor" href="#exercis
 </div>
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-      <img src="" class="logo" alt=""><h1>S4_inference: Definitions and exercises</h1>
+
+      <h1>S4_inference: Definitions and exercises</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S4_hypothesis_testing.Rmd" class="external-link"><code>vignettes/S4_hypothesis_testing.Rmd</code></a></small>
       <div class="d-none name"><code>S4_hypothesis_testing.Rmd</code></div>
@@ -359,8 +346,9 @@ <h2 id="conclusions">Conclusions<a class="anchor" aria-label="anchor" href="#con
 errors of Type I (reject a null hypothesis that is true) and Type II
 (fail to reject a false null). The power of a test procedure is
 one minus its Type II error probability.</p></li>
-<li>Typically the null hypothesis specifies the value of a parameter
-of a population distribution
+<li>
+<p>Typically the null hypothesis specifies the value of a parameter
+of a population distribution</p>
 <ul>
 <li>in the case of the card deck, the
 hypothesis of fairness of deck and shuffling procedure entails
@@ -370,7 +358,8 @@ <h2 id="conclusions">Conclusions<a class="anchor" aria-label="anchor" href="#con
 is binomial(N,1/4)</li>
 </ul>
 </li>
-<li>R’s <code>binom.test</code> is given
+<li>
+<p>R’s <code>binom.test</code> is given</p>
 <ul>
 <li>the sum of the number of hearts observed,</li>
 <li>the number of trials,</li>
@@ -393,41 +382,39 @@ <h2 id="conclusions">Conclusions<a class="anchor" aria-label="anchor" href="#con
 </ul>
 <div class="sourceCode" id="cb34"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/alexkowa/EnvStats" class="external-link">EnvStats</a></span><span class="op">)</span></span>
-<span><span class="fu"><a href="https://rdrr.io/pkg/EnvStats/man/propTestPower.html" class="external-link">propTestPower</a></span><span class="op">(</span><span class="fl">750</span>, p.or.p1<span class="op">=</span><span class="fl">13</span><span class="op">/</span><span class="fl">52</span>, p0<span class="op">=</span><span class="fl">.25</span> <span class="op">)</span></span></code></pre></div>
+<span><span class="fu"><a href="https://alexkowa.github.io/EnvStats/reference/propTestPower.html" class="external-link">propTestPower</a></span><span class="op">(</span><span class="fl">750</span>, p.or.p1<span class="op">=</span><span class="fl">13</span><span class="op">/</span><span class="fl">52</span>, p0<span class="op">=</span><span class="fl">.25</span> <span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## [1] 0.05</span></span></code></pre>
 <div class="sourceCode" id="cb36"><pre class="downlit sourceCode r">
-<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/EnvStats/man/propTestPower.html" class="external-link">propTestPower</a></span><span class="op">(</span><span class="fl">750</span>, p.or.p1<span class="op">=</span><span class="fl">14</span><span class="op">/</span><span class="fl">52</span>, p0<span class="op">=</span><span class="fl">.25</span> <span class="op">)</span></span></code></pre></div>
+<code class="sourceCode R"><span><span class="fu"><a href="https://alexkowa.github.io/EnvStats/reference/propTestPower.html" class="external-link">propTestPower</a></span><span class="op">(</span><span class="fl">750</span>, p.or.p1<span class="op">=</span><span class="fl">14</span><span class="op">/</span><span class="fl">52</span>, p0<span class="op">=</span><span class="fl">.25</span> <span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## [1] 0.2348789</span></span></code></pre>
 <div class="sourceCode" id="cb38"><pre class="downlit sourceCode r">
-<code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/EnvStats/man/propTestPower.html" class="external-link">propTestPower</a></span><span class="op">(</span><span class="fl">750</span>, p.or.p1<span class="op">=</span><span class="fl">15</span><span class="op">/</span><span class="fl">52</span>, p0<span class="op">=</span><span class="fl">.25</span> <span class="op">)</span></span></code></pre></div>
+<code class="sourceCode R"><span><span class="fu"><a href="https://alexkowa.github.io/EnvStats/reference/propTestPower.html" class="external-link">propTestPower</a></span><span class="op">(</span><span class="fl">750</span>, p.or.p1<span class="op">=</span><span class="fl">15</span><span class="op">/</span><span class="fl">52</span>, p0<span class="op">=</span><span class="fl">.25</span> <span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## [1] 0.6742566</span></span></code></pre>
 <p>An exercise is to reconcile these results with the simulation-based
 results given above.</p>
 <p>Another is to find the sample size needed to achieve 80% power to detect
 a single switch from diamond to heart in an otherwise fair deck.</p>
 </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside>
 </div>
 
 
 
     <footer><div class="pkgdown-footer-left">
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-      <img src="" class="logo" alt=""><h1>S5_inference: FDR, linear models, and GLMs</h1>
+
+      <h1>S5_inference: FDR, linear models, and GLMs</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S5_linear_models.Rmd" class="external-link"><code>vignettes/S5_linear_models.Rmd</code></a></small>
       <div class="d-none name"><code>S5_linear_models.Rmd</code></div>
@@ -96,8 +83,9 @@ <h2 id="review-of-some-inference-concepts">Review of some inference concepts<a c
 <h3 id="error-rates-size-and-power">Error rates: size and power<a class="anchor" aria-label="anchor" href="#error-rates-size-and-power"></a>
 </h3>
 <ul>
-<li>Null hypothesis testing framework: we typically aim to assess whether
-an intervention affects a parameter value for a certain population
+<li>
+<p>Null hypothesis testing framework: we typically aim to assess whether
+an intervention affects a parameter value for a certain population</p>
 <ul>
 <li>does the average value of some quantity change after treatment?</li>
 <li>does changing the composition of a deck of cards affect the
@@ -202,7 +190,7 @@ <h3 id="bonferronis-correction-to-achieve-family-wise-error-rate-fwer-control">B
 <p>This table is frequently seen in discussions of multiple testing, it is
 from Holmes and Huber’s Modern Statistics for Modern Biology.</p>
 <div class="figure">
-<img src="MTESTTAB.jpg" alt="decisiontab"><p class="caption">decisiontab</p>
+<img src="MTESTTAB.jpg" alt=""><p class="caption">decisiontab</p>
 </div>
 <p>Suppose we have <span class="math inline">\(m\)</span> hypotheses to test and we wish the overall
 probability of our family of tests to have Type I error rate <span class="math inline">\(\alpha\)</span>.
@@ -236,28 +224,28 @@ <h3 id="adjusted-p-values">Adjusted p-values<a class="anchor" aria-label="anchor
 <span><span class="fu"><a href="https://rdrr.io/r/base/options.html" class="external-link">options</a></span><span class="op">(</span>digits<span class="op">=</span><span class="fl">3</span><span class="op">)</span></span>
 <span><span class="va">tab</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/multtest/man/mt.rawp2adjp.html" class="external-link">mt.rawp2adjp</a></span><span class="op">(</span><span class="va">many_p</span><span class="op">)</span></span>
 <span><span class="fu"><a href="https://rdrr.io/r/utils/head.html" class="external-link">head</a></span><span class="op">(</span><span class="va">tab</span><span class="op">[[</span><span class="fl">1</span><span class="op">]</span><span class="op">]</span>,<span class="fl">10</span><span class="op">)</span></span></code></pre></div>
-<pre><code><span><span class="co">##           rawp Bonferroni   Holm Hochberg SidakSS SidakSD     BH    BY    ABH</span></span>
-<span><span class="co">##  [1,] 1.07e-06     0.0107 0.0107   0.0107  0.0106  0.0106 0.0107 0.104 0.0107</span></span>
-<span><span class="co">##  [2,] 7.94e-05     0.7944 0.7943   0.7943  0.5481  0.5481 0.3972 1.000 0.3972</span></span>
-<span><span class="co">##  [3,] 2.75e-04     1.0000 1.0000   1.0000  0.9359  0.9359 0.6588 1.000 0.6588</span></span>
-<span><span class="co">##  [4,] 3.00e-04     1.0000 1.0000   1.0000  0.9502  0.9502 0.6588 1.000 0.6588</span></span>
-<span><span class="co">##  [5,] 3.29e-04     1.0000 1.0000   1.0000  0.9629  0.9629 0.6588 1.000 0.6588</span></span>
-<span><span class="co">##  [6,] 5.51e-04     1.0000 1.0000   1.0000  0.9959  0.9959 0.8190 1.000 0.8190</span></span>
-<span><span class="co">##  [7,] 5.97e-04     1.0000 1.0000   1.0000  0.9974  0.9974 0.8190 1.000 0.8190</span></span>
-<span><span class="co">##  [8,] 7.80e-04     1.0000 1.0000   1.0000  0.9996  0.9996 0.8190 1.000 0.8190</span></span>
-<span><span class="co">##  [9,] 9.25e-04     1.0000 1.0000   1.0000  0.9999  0.9999 0.8190 1.000 0.8190</span></span>
-<span><span class="co">## [10,] 9.44e-04     1.0000 1.0000   1.0000  0.9999  0.9999 0.8190 1.000 0.8190</span></span>
+<pre><code><span><span class="co">##           rawp Bonferroni  Holm Hochberg SidakSS SidakSD    BH BY   ABH</span></span>
+<span><span class="co">##  [1,] 9.27e-05      0.927 0.927    0.927   0.604   0.604 0.645  1 0.645</span></span>
+<span><span class="co">##  [2,] 1.81e-04      1.000 1.000    1.000   0.836   0.836 0.645  1 0.645</span></span>
+<span><span class="co">##  [3,] 3.93e-04      1.000 1.000    1.000   0.980   0.980 0.645  1 0.645</span></span>
+<span><span class="co">##  [4,] 4.35e-04      1.000 1.000    1.000   0.987   0.987 0.645  1 0.645</span></span>
+<span><span class="co">##  [5,] 4.40e-04      1.000 1.000    1.000   0.988   0.988 0.645  1 0.645</span></span>
+<span><span class="co">##  [6,] 4.43e-04      1.000 1.000    1.000   0.988   0.988 0.645  1 0.645</span></span>
+<span><span class="co">##  [7,] 4.96e-04      1.000 1.000    1.000   0.993   0.993 0.645  1 0.645</span></span>
+<span><span class="co">##  [8,] 6.28e-04      1.000 1.000    1.000   0.998   0.998 0.645  1 0.645</span></span>
+<span><span class="co">##  [9,] 6.82e-04      1.000 1.000    1.000   0.999   0.999 0.645  1 0.645</span></span>
+<span><span class="co">## [10,] 7.14e-04      1.000 1.000    1.000   0.999   0.999 0.645  1 0.645</span></span>
 <span><span class="co">##       TSBH_0.05</span></span>
-<span><span class="co">##  [1,]    0.0107</span></span>
-<span><span class="co">##  [2,]    0.3971</span></span>
-<span><span class="co">##  [3,]    0.6587</span></span>
-<span><span class="co">##  [4,]    0.6587</span></span>
-<span><span class="co">##  [5,]    0.6587</span></span>
-<span><span class="co">##  [6,]    0.8189</span></span>
-<span><span class="co">##  [7,]    0.8189</span></span>
-<span><span class="co">##  [8,]    0.8189</span></span>
-<span><span class="co">##  [9,]    0.8189</span></span>
-<span><span class="co">## [10,]    0.8189</span></span></code></pre>
+<span><span class="co">##  [1,]     0.645</span></span>
+<span><span class="co">##  [2,]     0.645</span></span>
+<span><span class="co">##  [3,]     0.645</span></span>
+<span><span class="co">##  [4,]     0.645</span></span>
+<span><span class="co">##  [5,]     0.645</span></span>
+<span><span class="co">##  [6,]     0.645</span></span>
+<span><span class="co">##  [7,]     0.645</span></span>
+<span><span class="co">##  [8,]     0.645</span></span>
+<span><span class="co">##  [9,]     0.645</span></span>
+<span><span class="co">## [10,]     0.645</span></span></code></pre>
 <p>By default, <code>mt.rawp2adp</code> produces a number of adjustments – we are concerned
 at present with the columns rawp (the p-values sorted from lowest on), Bonferroni
 (which gives the transformation <span class="math inline">\(p\)</span> to min(1, mp)$ for <span class="math inline">\(m\)</span> tests),
@@ -877,28 +865,26 @@ <h3 id="random-effects-models-for-clustered-observations">Random effects models
 <p>Approximate mixed effects models for the GLM families can be fit using glmmPQL in MASS.</p>
 </div>
 </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside>
 </div>
 
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
 </div>
 
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-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
 </div>
 
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index db9be7f..59ed236 100644
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@@ -5,82 +5,72 @@
 <meta charset="utf-8">
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 <title>S5a: Diagnostics of a differential gene expression exercise • CSHstats</title>
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
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-      <img src="" class="logo" alt=""><h1>S5a: Diagnostics of a differential gene expression exercise</h1>
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+      <h1>S5a: Diagnostics of a differential gene expression exercise</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
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       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S5a_lmdiagnostics.Rmd" class="external-link"><code>vignettes/S5a_lmdiagnostics.Rmd</code></a></small>
       <div class="d-none name"><code>S5a_lmdiagnostics.Rmd</code></div>
@@ -188,28 +178,26 @@ <h2 id="assessing-the-association-by-hand">Assessing the association “by hand
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">m1</span>, which<span class="op">=</span><span class="fl">2</span>, col<span class="op">=</span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/numeric.html" class="external-link">as.numeric</a></span><span class="op">(</span><span class="va">mydf</span><span class="op">$</span><span class="va">prenatalprenatal</span><span class="op">)</span><span class="op">+</span><span class="fl">1</span><span class="op">)</span>, pch<span class="op">=</span><span class="fl">19</span><span class="op">)</span></span></code></pre></div>
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-      <img src="" class="logo" alt=""><h1>S5b: hypothesis testing in nonlinear regression</h1>
+
+      <h1>S5b: hypothesis testing in nonlinear regression</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S5b_nonlin.Rmd" class="external-link"><code>vignettes/S5b_nonlin.Rmd</code></a></small>
       <div class="d-none name"><code>S5b_nonlin.Rmd</code></div>
@@ -136,43 +126,41 @@ <h2 id="fitting-the-model-to-data">Fitting the model to data<a class="anchor" ar
 <span><span class="co">## Residual standard error: 0.4515 on 11 degrees of freedom</span></span>
 <span><span class="co">## </span></span>
 <span><span class="co">## Number of iterations to convergence: 14 </span></span>
-<span><span class="co">## Achieved convergence tolerance: 4.653e-06</span></span></code></pre>
+<span><span class="co">## Achieved convergence tolerance: 4.863e-06</span></span></code></pre>
 <p>Let’s use the model to overlay predicted response curves on the original data.</p>
 <div class="sourceCode" id="cb5"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/plot.html" class="external-link">plot</a></span><span class="op">(</span><span class="va">y</span><span class="op">~</span><span class="va">x</span>,data<span class="op">=</span><span class="va">nonlindat</span>, col<span class="op">=</span><span class="va">nonlindat</span><span class="op">$</span><span class="va">z</span><span class="op">+</span><span class="fl">1</span>, pch<span class="op">=</span><span class="fl">19</span><span class="op">)</span></span>
 <span><span class="va">nd</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span>x<span class="op">=</span><span class="fl">1</span><span class="op">:</span><span class="fl">8</span>,z<span class="op">=</span><span class="fl">0</span><span class="op">)</span></span>
-<span><span class="va">y1</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/EnvStats/man/predict.html" class="external-link">predict</a></span><span class="op">(</span><span class="va">nl1</span>, newdata<span class="op">=</span><span class="va">nd</span><span class="op">)</span></span>
+<span><span class="va">y1</span> <span class="op">=</span> <span class="fu"><a href="https://alexkowa.github.io/EnvStats/reference/predict.html" class="external-link">predict</a></span><span class="op">(</span><span class="va">nl1</span>, newdata<span class="op">=</span><span class="va">nd</span><span class="op">)</span></span>
 <span><span class="fu"><a href="https://rdrr.io/r/graphics/lines.html" class="external-link">lines</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">8</span>, <span class="va">y1</span>, lty<span class="op">=</span><span class="fl">2</span><span class="op">)</span></span>
 <span><span class="va">nd2</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/data.frame.html" class="external-link">data.frame</a></span><span class="op">(</span>x<span class="op">=</span><span class="fl">1</span><span class="op">:</span><span class="fl">8</span>,z<span class="op">=</span><span class="fl">1</span><span class="op">)</span></span>
-<span><span class="va">y2</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/EnvStats/man/predict.html" class="external-link">predict</a></span><span class="op">(</span><span class="va">nl1</span>, newdata<span class="op">=</span><span class="va">nd2</span><span class="op">)</span></span>
+<span><span class="va">y2</span> <span class="op">=</span> <span class="fu"><a href="https://alexkowa.github.io/EnvStats/reference/predict.html" class="external-link">predict</a></span><span class="op">(</span><span class="va">nl1</span>, newdata<span class="op">=</span><span class="va">nd2</span><span class="op">)</span></span>
 <span><span class="fu"><a href="https://rdrr.io/r/graphics/lines.html" class="external-link">lines</a></span><span class="op">(</span><span class="fl">1</span><span class="op">:</span><span class="fl">8</span>, <span class="va">y2</span>, lty<span class="op">=</span><span class="fl">2</span>, col<span class="op">=</span><span class="st">"red"</span><span class="op">)</span></span></code></pre></div>
 <p><img src="S5b_nonlin_files/figure-html/relook-1.png" width="700"></p>
 <p>In summary, there is some evidence of a shift, location of inflection point shifted by about 0.24 in units of x, with a p-value of about 0.079. It seems clear that the model fits one condition much better than the other.</p>
 <p>Exercise: The abline function can be used to sketch aspects of the model over the plot just given. For example, <code>abline(h=4.4419, lty=2)</code> draws a dashed line representing the fitted upper asymptote. Use the estimated a, b, d parameters to draw “cross-hairs” showing the location of the inflection point for the black curve, by filling in the appropriate values of <code>abline(v=?, h=?)</code>.</p>
 <p>Exercise (advanced): Test the hypothesis that the two conditions have different asymptotic values as x increases.</p>
 </div>
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-      <img src="" class="logo" alt=""><h1>S6 HCA, ontologies, shiny</h1>
+
+      <h1>S6 HCA, ontologies, shiny</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S6_hca_onto.Rmd" class="external-link"><code>vignettes/S6_hca_onto.Rmd</code></a></small>
       <div class="d-none name"><code>S6_hca_onto.Rmd</code></div>
@@ -107,10 +95,10 @@ <h2 id="road-map">Road map<a class="anchor" aria-label="anchor" href="#road-map"
 <h2 id="a-paper-on-the-atlas-of-the-prostate">A paper on the atlas of the prostate<a class="anchor" aria-label="anchor" href="#a-paper-on-the-atlas-of-the-prostate"></a>
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 </div>
 <div class="section level3">
 <h3 id="the-hca-package">The hca package<a class="anchor" aria-label="anchor" href="#the-hca-package"></a>
@@ -123,8 +111,8 @@ <h4 id="surveying-projects-of-the-hca">Surveying projects of the HCA<a class="an
 <span><span class="va">p</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/hca/man/projects.html" class="external-link">projects</a></span><span class="op">(</span>size <span class="op">=</span> <span class="fl">200</span><span class="op">)</span>; <span class="va">p</span> <span class="op">=</span> <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/bind_rows.html" class="external-link">bind_rows</a></span><span class="op">(</span><span class="va">p</span>, <span class="fu"><a href="https://rdrr.io/pkg/hca/man/hca.html" class="external-link">hca_next</a></span><span class="op">(</span><span class="va">p</span><span class="op">)</span><span class="op">)</span> <span class="co"># workaround bug upstream to 1.4.0</span></span>
 <span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/rstudio/DT" class="external-link">DT</a></span><span class="op">)</span></span>
 <span><span class="fu"><a href="https://rdrr.io/pkg/DT/man/datatable.html" class="external-link">datatable</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/BiocGenerics/man/as.data.frame.html" class="external-link">as.data.frame</a></span><span class="op">(</span><span class="va">p</span><span class="op">)</span><span class="op">)</span></span></code></pre></div>
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Million Brain Cells from E18 Mice","A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra","A Cellular Atlas of Pitx2-Dependent Cardiac Development.","A Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors","A Partial Picture of the Single-Cell Transcriptomics of Human IgA Nephropathy","A Protocol for Revealing Oral Neutrophil Heterogeneity by Single-Cell Immune Profiling in Human Saliva","A Single-Cell Atlas of the Human Healthy Airways.","A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization","A Single-Cell Transcriptome Atlas of Glia Diversity in the Human Hippocampus across the Lifespan and in Alzheimer’s Disease","A Single-Cell Transcriptomic Atlas of Human Skin Aging.","A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure","A Single-cell Transcriptomic Atlas of Human Intervertebral Disc","A blood atlas of COVID-19 defines hallmarks of disease severity and specificity","A cell atlas of human thymic development defines T cell repertoire formation","A cellular census of human lungs identifies novel cell states in health and in asthma","A comprehensive single cell transcriptional landscape of human hematopoietic progenitors","A human breast atlas integrating single-cell proteomics and transcriptomics","A human cell atlas of fetal gene expression.","A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates","A human single cell atlas of the substantia nigra reveals novel cell specific pathways associated with the genetic risk of Parkinson’s disease and neuropsychiatric disorders.","A molecular single-cell lung atlas of lethal COVID-19","A multi-omic single-cell landscape of human gynecologic malignancies","A multi-omics atlas of the human retina at single-cell resolution","A multi-omics atlas of the human retina at single-cell resolution","A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics","A revised airway epithelial hierarchy includes CFTR-expressing ionocytes","A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells.","A single cell atlas of human teeth","A single cell atlas of the human liver tumor microenvironment","A single cell atlas of the human proximal epididymis reveals cell-type specific functions and distinct roles for CFTR","A single cell immune cell atlas of human hematopoietic system","A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumors.","A single-cell atlas of breast cancer cell lines to study tumour heterogeneity and drug response","A single-cell atlas of chromatin accessibility in the human genome","A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells","A single-cell molecular map of mouse gastrulation and early organogenesis","A single-cell reference map of transcriptional states for human blood and tissue T cell activation","A single-cell regulatory map of postnatal lung alveologenesis in humans and mice","A single-cell survey of the human first-trimester placenta and decidua","A single-cell transcriptome atlas of human early embryogenesis","A single-cell transcriptome atlas of the adult human retina","A single-cell transcriptomic atlas of the human ciliary body","A spatially resolved atlas of the human lung characterizes a gland-associated immune niche","A survey of human brain transcriptome diversity at the single cell level","AIDA","Airspace Macrophages and Monocytes Exist in Transcriptionally Distinct Subsets in Healthy Adults","Altered human oligodendrocyte heterogeneity in multiple sclerosis","An Atlas of Immune Cell Exhaustion in HIV-Infected Individuals Revealed by Single-Cell Transcriptomics.","An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestine","Assessing the relevance of organoids to model inter-individual variation","Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects","Blood and immune development in human fetal bone marrow and Down syndrome","Bone marrow plasma cells from hip replacement surgeries","CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function","CD90 marks a mesenchymal program in human thymic epithelial cells in vitro and in vivo","CITE-seq of in vitro control and memory-like human NK cells","COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.","COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.","COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.","Capturing human trophoblast development with naive pluripotent stem cells in vitro","Cell Atlas of The Human Fovea and Peripheral Retina.","Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution","Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types","Cell hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics","Cells of the adult human heart","Cells of the human intestinal tract mapped across space and time","Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified by scRNA-seq","Characterization of altered molecular mechanisms in Parkinson's disease through cell type-resolved multiomics analyses","Characterization of the transcriptional landscape of human developing hippocampus","Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia.","Co-evolution of tumor and immune cells during progression of multiple myeloma.","Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis","Colonic single epithelial cell census reveals goblet cell drivers of barrier breakdown in inflammatory bowel disease.","Combinatorial transcription factor profiles predict mature and functional human islet α and β cells","Comparative analysis of kidney organoid and adult human kidney single cell and single nucleus transcriptomes","Comparison of manual and two types of bioprinted kidney organoids by single cell RNA-seq.","Comparison, calibration, and benchmarking of high-throughput single cell RNA-Seq techniques for unbiased cell-type classification","Comprehensive cell atlas of the first-trimester developing human brain","Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues","Conserved cell types with divergent features in human versus mouse cortex.","Construction of A Human Cell Landscape by Single-cell mRNA-seq","Construction of a single-cell transcriptomic atlas of 58,243 liver cells from 4 donors and 4 recipient liver transplasnt patients to investigate early allograft dysfunction (EAD).","Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts","Cross-tissue immune cell analysis reveals tissue-specific features in humans","Cryopreservation and post-thaw characterization of dissociated human islet cells","Decoding Human Megakaryocyte Development","Decoding human fetal liver haematopoiesis","Defining Transcriptional Signatures of Human Hair Follicle Cell States","Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease","Defining the Activated Fibroblast Population in Lung Fibrosis Using Single Cell Sequencing.","Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts","Developmental cell programs are co-opted in inflammatory skin disease.","Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin","Differential dynamics of response at single cell resolution following CAR-T therapy in refractory B-cell lymphoma","Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps","Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells","Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair response","Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages","Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing","Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium","Dissecting the clonal nature of allelic expression in somatic cells by single-cell RNA-seq","Dissecting the human liver cellular landscape by single cell RNA-seq reveals novel intrahepatic monocyte/ macrophage populations","Dissecting the protein and transcriptional responses of human immune cells to T cell and monocyte specific activation","Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.","Dissecting transcriptional and chromatin accessibility heterogeneity of proliferating cone precursors in human retinoblastoma tumours by single cell sequencing","Distinct microbial and immune niches of the human colon","Dynamic changes in human single cell transcriptional signatures during fatal sepsis","Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution","Expansion of Fcγ Receptor IIIa-Positive Macrophages, Ficolin 1-Positive Monocyte-Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis","Extreme heterogeneity of influenza virus infection in single cells","Fate-mapping within human iPSC-derived kidney organoids reveals conserved mammalian nephron progenitor lineage relationships.","Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation [Female]","Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation [Male]","GM-CSF-producing T helper cells: a distinct subset of T helper cells.","Genome-Wide DNA Hypermethylation in the Wound-Edge of Chronic Wound Patients Opposes Closure by Impairing Epithelial to Mesenchymal Transition","Genomic profiling of human spermatogonial stem cells","HCA seed network precise tumor-nephrectomy samples","Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing To Define Immune Cell Chimerism in the Rejecting Kidney Transplant","Healthy human kidney cell type single cell RNA-seq data","Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses","High throughput error corrected Nanopore single cell transcriptome sequencing.","Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.","Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.","Human distal lung maps and lineage hierarchies reveal a bipotent progenitor","Human melanocyte development and melanoma dedifferentiation at single-cell resolution","Human photoreceptor cells from different macular subregions have distinct transcriptional profiles","Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution","Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19","Identification of a mesenchymal progenitor cell hierarchy in adipose tissue (scRNA-seq)","Identification of a unique subset of tissue-resident memory CD4+ T cells in Crohn’s disease","Identification of distinct synovial fibroblast subsets associated with pain and progression of knee osteoarthritis using single-cell RNA sequencing","Immune cell profiling of preeclamptic pregnant and postpartum women by single-cell RNA sequencing","Immune landscape of viral- and carcinogen-drived head and neck cancer","Immune signatures underlying post-acute COVID-19 lung sequelae","Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19","Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19","Improving fibroblast characterization using single-cell RNA sequencing: an optimized tissue disaggregation and data processing pipeline.","In Vitro and In Vivo Development of the Human Airway at Single-Cell Resolution","Integrated analysis of multimodal single-cell data","Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes","Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis.","Integrated single-cell transcriptomics and epigenomics reveals strong germinal center–associated etiology of autoimmune risk loci","Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration","Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers","Integrative computational analysis of the substantia nigra pars compacta and the locus coeruleus","Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis.","Intrarenal Single-Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy.","Intratumoral heterogeneity in recurrent pediatric pilocytic astrocytomas","Ischaemic sensitivity of human tissue by single cell RNA seq","Joint profiling of chromatin accessibility and gene expression in thousands of single cells","Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells.","Kidney organoid reproducibility across multiple human iPSC lines and diminished off target cells after transplantation revealed by single cell transcriptomics","Lifespan charactarization of the nasal mucosa","Lineage recording in human cerebral organoids.","Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer.","Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.","Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.","Lung transplantation for patients with severe COVID-19","Mapping Development of the Human Intestinal Niche at Single-Cell Resolution","Mapping the developing human immune system across organs","Mapping the immune environment in clear cell renal carcinoma by single-cell genomics","Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro","Marked regional glial heterogeneity in the human white matter of the central nervous system","Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior","Massively parallel single-cell RNA-seq analysis of 26,677 pancreatic islets cells from both healthy and type II diabetic (T2D) donors.","Melanoma infiltration of stromal and immune cells","Memory-like natural killer cells facilitate effector functions of daratumumab in multiple myeloma","Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.","Modeling Hepatoblastoma: Identification of Distinct Tumor Cell Populations and Key Genetic Mechanisms through Single Cell Sequencing (scRNA-seq)","Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids.","Molecular Architecture of the Mouse Nervous System.","Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.","Molecular signatures of inflammatory profile and B-cell function in SFTS patients","Molecular transitions in early progenitors during human cord blood hematopoiesis","Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways","Multimodal single cell sequencing of human diabetic kidney disease implicates chromatin accessibility and genetic background in disease progression","Multiplexing droplet-based single cell RNA-sequencing using genetic barcodes","Nuclei multiplexing with barcoded antibodies for single-nucleus genomics.","Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis'","Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease","Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk.","Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.","Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis","Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation","Profiling of CD34+ cells from human bone marrow to understand hematopoiesis","Profiling of transcribed cis-regulatory elements in single cells.","Pseudo-temporal ordering of individual cells reveals regulators of differentiation","RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes","RNA-Seq from human innate lymphoid cells (ILCs) transitional populations.","Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.","Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds.","Reconstructing the human first trimester fetal-maternal interface using single cell transcriptomics","Refining Colorectal Cancer Classification and Clinical Stratification Through a Single-Cell Atlas","Regenerative lineages and immune-mediated pruning in lung cancer metastasis","Resolving cellular and molecular diversity along the hippocampal anterior-to-posterior axis in humans","Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics","Retinal ganglion cell-specific genetic regulation in primary open angle glaucoma","Robust temporal map of human in vitro myelopoiesis using single-cell genomics.","SARS-CoV-2 infection of the oral cavity and saliva.","SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.","SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells","Sampling time-dependent artifacts in single-cell genomics studies","Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment","Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor.","Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology","Single Cell RNA-Seq Analysis Reveals  Fate Decision of Human Pre-cDC Determined  by Transcription Factor Competition","Single Cell RNA-Seq profiling human embryonic kidney cortex cells","Single Cell RNA-Seq profiling of human embryonic kidney outer and inner cortical cells and kidney organoid cells","Single Cell RNA-Sequencing of Human Limb Skeletal Muscle across Development and Myogenic Culture from Pluripotent Stem Cells","Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary Fibrosis","Single Cell RNAseq of primary pulmonary endothelial cells.","Single Cell Transcriptomics Reveals Cell Type Specific Diversification in Human Heart Failure","Single Cell Transcriptomics of a Human Kidney Allograft Biopsy Defines a Diverse Inflammatory Response","Single Cell, Single Nucleus and Spatial RNA Sequencing of the Human Liver Identifies Hepatic Stellate Cell and Cholangiocyte Heterogeneity","Single cell RNA sequencing of human failing heart","Single cell RNA sequencing of multiple myeloma II","Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis","Single cell RNA-Seq of E18.5 developing mouse kidney and human kidney organoids","Single cell RNA-seq analysis of adult and paediatric IDH-wildtype Glioblastomas","Single cell RNA-seq of HeLa CCL2","Single cell RNA-seq of brain glioblastoma samples","Single cell RNA-seq of human pancreatic endocrine cells from Juvenile, adult control and type 2 diabetic donors.","Single cell RNA-sequencing of human tonsil Innate lymphoid cells (ILCs)","Single cell RNA-sequencing on healthy and IPF lung mesenchymal cells.","Single cell RNAseq analysis of the developmental trajectory of iPSC-derived tenocytes","Single cell RNAseq of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium","Single cell analysis of endometriosis reveals a coordinated transcriptional program driving immunotolerance and angiogenesis across eutopic and ectopic tissues","Single cell analysis of human fetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors","Single cell landscape of mesenchymal and endothelial cells in healthy human liver","Single cell profiling of human induced dendritic cells generated by direct reprogramming of embryonic fibroblasts","Single cell sequencing identifies novel sub-populations of breast cancer cells selected under hypoxia","Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney","Single cell transcriptional profiling of peripheral blood mononuclear cells (PBMCs) from mice flown on Rodent Research Reference Mission-2 (RRRM-2)","Single cell transcriptional profiling of spleens from mice flown on Rodent Research Reference Mission-2","Single cell transcriptome analysis of human pancreas reveals transcriptional signatures of aging and somatic mutation patterns.","Single cell transcriptome atlases of the developing mouse and human spinal cord.","Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease","Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes [single cell]","Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker.","Single cell transcriptomics of human epidermis identifies basal stem cell transition states.","Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord","Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord.","Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer","Single-Cell Lymphocyte Heterogeneity in Advanced Cutaneous T-cell Lymphoma Skin Tumors","Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.","Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis.","Single-Cell RNA Sequencing Reveals Human iPS Cell-derived Alveolar Type 1 Cells in Alveolar Organoids","Single-Cell RNA Sequencing in Multiple Pathologic Types of Renal Cell Carcinoma Revealed Novel Potential Tumor-Specific Markers.","Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal- Niche Interactions","Single-Cell RNA-Seq Analysis of cells from human urine","Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-infected Cells","Single-Cell RNAseq analysis of diffuse neoplastic infiltrating cells at the migrating front of human glioblastoma","Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell","Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.","Single-Cell Transcriptomic Profiling of Human Dental Pulp in Sound and Carious Teeth: A Pilot Study","Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy","Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury.","Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis","Single-Cell Transcriptomics of Human Substantia Nigra in Parkinson's Disease","Single-cell ATAC sequencing reveals the mechanism of human breast cancer metastasis","Single-cell RNA Sequencing of human microglia from post mortem Alzheimers Disease CNS tissue.","Single-cell RNA sequencing identifies cell type-specific cis-eQTLs and co-expression QTLs","Single-cell RNA sequencing of human femoral head in vivo","Single-cell RNA sequencing of human nasal swab from healthy donors","Single-cell RNA sequencing of normal human kidney","Single-cell RNA sequencing of peripheral blood reveals immune cell signatures in Alzheimer's disease","Single-cell RNA sequencing of urinary cells reveals distinct cellular diversity in COVID-19-associated AKI","Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human.","Single-cell RNA-Seq Investigation of Foveal and Peripheral Expression in the Human Retina","Single-cell RNA-Seq of human hepatocyte-derived liver progenitor-like cells","Single-cell RNA-Seq reveals a developmental atlas of human prefrontal cortex","Single-cell RNA-seq analysis  throughout a 125-day differentiation protocol that converted H1 human embryonic stem cells to a variety of ventrally-derived cell types.","Single-cell RNA-seq analysis of human pancreas from healthy individuals and type 2 diabetes patients","Single-cell RNA-seq in monozygotic twins discordant for multiple sclerosis","Single-cell RNA-seq of bone marrow cells from aplastic anemia patient and healthy donor","Single-cell RNA-seq of human peripheral blood NKT cells","Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus","Single-cell RNA-seq reveals heterogeneity within human pre-cDCs","Single-cell RNA-seq to decipher the subpopulations of human decidual leukocytes in normal and RSA pregnancies","Single-cell RNA-sequencing reveals pervasive but highly cell type-specific genetic ancestry effects on the response to viral infection","Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis","Single-cell RNA-sequencing reveals the landscape of cervical cancer heterogeneity","Single-cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue.","Single-cell Transcriptome Analysis Reveals an Anomalous Epithelial Variation and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease","Single-cell Transcriptome Atlas of Testis Aging","Single-cell Transcriptome Atlas of the Human Corpus Cavernosum","Single-cell analyses of Crohn's disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions","Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response","Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy","Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity","Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity","Single-cell analysis of human B cell maturation predicts how antibody class switching 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Million Brain Cells from E18 Mice","A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra","A Cellular Atlas of Pitx2-Dependent Cardiac Development.","A Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors","A Partial Picture of the Single-Cell Transcriptomics of Human IgA Nephropathy","A Protocol for Revealing Oral Neutrophil Heterogeneity by Single-Cell Immune Profiling in Human Saliva","A Single-Cell Atlas of the Human Healthy Airways","A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization","A Single-Cell Transcriptome Atlas of Glia Diversity in the Human Hippocampus across the Lifespan and in Alzheimer’s Disease","A Single-Cell Transcriptome Atlas of the Human Pancreas.","A Single-Cell Transcriptomic Atlas of Human Skin Aging.","A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure","A Single-cell Transcriptomic Atlas of Human Intervertebral Disc","A cell atlas of human thymic development defines T cell repertoire formation","A cellular census of human lungs identifies novel cell states in health and in asthma","A comprehensive single cell transcriptional landscape of human hematopoietic progenitors","A human breast atlas integrating single-cell proteomics and transcriptomics","A human cell atlas of fetal gene expression.","A human cell atlas of the pressure-induced hypertrophic heart","A human embryonic limb cell atlas resolved in space and time","A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates","A human single cell atlas of the substantia nigra reveals novel cell specific pathways associated with the genetic risk of Parkinson’s disease and neuropsychiatric disorders.","A molecular cell atlas of the human lung from single-cell RNA sequencing","A molecular single-cell lung atlas of lethal COVID-19","A multi-omic single-cell landscape of human gynecologic malignancies","A multi-omics atlas of the human retina at single-cell resolution","A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics","A revised airway epithelial hierarchy includes CFTR-expressing ionocytes","A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells.","A single cell atlas of the human liver tumor microenvironment","A single cell atlas of the human proximal epididymis reveals cell-type specific functions and distinct roles for CFTR","A single cell immune cell atlas of human hematopoietic system","A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumors.","A single-cell atlas of breast cancer cell lines to study tumour heterogeneity and drug response","A single-cell atlas of chromatin accessibility in the human genome","A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.","A single-cell atlas of human teeth","A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells","A single-cell molecular map of mouse gastrulation and early organogenesis","A single-cell regulatory map of postnatal lung alveologenesis in humans and mice","A single-cell survey of the human first-trimester placenta and decidua","A single-cell transcriptome atlas of human early embryogenesis","A single-cell transcriptome atlas of the adult human retina","A single-cell transcriptomic atlas of the human ciliary body","A spatial human thymus cell atlas mapped to a continuous tissue axis","A spatially resolved atlas of the human lung characterizes a gland-associated immune niche","A spatially resolved single-cell genomic atlas of the adult human breast","A survey of human brain transcriptome diversity at the single cell level","A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation","A transcriptional cross species map of pancreatic islet cells.","AIDA","Activation of CD8+ T Cells in Chronic Obstructive Pulmonary Disease Lung","Airspace Macrophages and Monocytes Exist in Transcriptionally Distinct Subsets in Healthy Adults","Allergic inflammatory memory in human respiratory epithelial progenitor cells","Altered human oligodendrocyte heterogeneity in multiple sclerosis","An Atlas of Cells in the Human Tonsil","An Atlas of Immune Cell Exhaustion in HIV-Infected Individuals Revealed by Single-Cell Transcriptomics.","An Optimized Tissue Dissociation Protocol for Single-Cell RNA Sequencing Analysis of Fresh and Cultured Human Skin Biopsies","An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestine","Anatomically distinct fibroblast subsets determine skin autoimmune patterns.","Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease","Assessing Cellular and Transcriptional diversity of IIeal Mucosa amongst Treatment Naïve and Treated Crohn’s disease","Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects","Blood and immune development in human fetal bone marrow and Down syndrome","Bone marrow plasma cells from hip replacement surgeries","CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function","CD90 marks a mesenchymal program in human thymic epithelial cells in vitro and in vivo","CITE-seq of in vitro control and memory-like human NK cells","COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.","COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.","COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.","Capturing human trophoblast development with naive pluripotent stem cells in vitro","Cardiac cell type-specific gene regulatory programs and disease risk association","Cell Atlas of The Human Fovea and Peripheral Retina.","Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution","Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types","Cell hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics","Cell type-specific and disease-associated eQTL in the human lung","Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids","Cells of the adult human heart","Cells of the human intestinal tract mapped across space and time","Cellular atlas of the human ovary using morphologically guided spatial transcriptomics and single-cell sequencing","Cellular development and evolution of the mammalian cerebellum","Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified by scRNA-seq","Characterization of altered molecular mechanisms in Parkinson's disease through cell type-resolved multiomics analyses","Characterization of the transcriptional landscape of human developing hippocampus","Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia.","Classification of human chronic inflammatory skin disease based on single-cell immune profiling","Co-evolution of tumor and immune cells during progression of multiple myeloma.","Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis","Colonic single epithelial cell census reveals goblet cell drivers of barrier breakdown in inflammatory bowel disease.","Combinatorial transcription factor profiles predict mature and functional human islet α and β cells","Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics","Comparison of manual and two types of bioprinted kidney organoids by single cell RNA-seq.","Comparison, calibration, and benchmarking of high-throughput single cell RNA-Seq techniques for unbiased cell-type classification","Comprehensive cell atlas of the first-trimester developing human brain","Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues","Conserved cell types with divergent features in human versus mouse cortex.","Construction of A Human Cell Landscape by Single-cell mRNA-seq","Construction of a single-cell transcriptomic atlas of 58,243 liver cells from 4 donors and 4 recipient liver transplasnt patients to investigate early allograft dysfunction (EAD).","Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts","Cross-tissue immune cell analysis reveals tissue-specific features in humans","Cryopreservation and post-thaw characterization of dissociated human islet cells","Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins","Decoding Human Megakaryocyte Development","Decoding human fetal liver haematopoiesis","Defining Transcriptional Signatures of Human Hair Follicle Cell States","Defining cardiac functional recovery in end-stage heart failure at single-cell resolution.","Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease","Defining the Activated Fibroblast Population in Lung Fibrosis Using Single Cell Sequencing.","Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts","Developmental cell programs are co-opted in inflammatory skin disease.","Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin","Differential dynamics of response at single cell resolution following CAR-T therapy in refractory B-cell lymphoma","Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps","Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells","Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair response","Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages","Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing","Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium","Dissecting the clonal nature of allelic expression in somatic cells by single-cell RNA-seq","Dissecting the protein and transcriptional responses of human immune cells to T cell and monocyte specific activation","Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.","Dissecting transcriptional and chromatin accessibility heterogeneity of proliferating cone precursors in human retinoblastoma tumours by single cell sequencing","Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation","Distinct microbial and immune niches of the human colon","Dynamic changes in human single cell transcriptional signatures during fatal sepsis","Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage.","Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir","Dysregulation of brain and choroid plexus cell types in severe COVID-19.","Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution","Evolution of neuronal cell classes and types in the vertebrate retina","Extreme heterogeneity of influenza virus infection in single cells","Fate-mapping within human iPSC-derived kidney organoids reveals conserved mammalian nephron progenitor lineage relationships.","Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation [Female]","Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation [Male]","GM-CSF-producing T helper cells: a distinct subset of T helper cells.","Generation of human islet cell type-specific identity genesets.","Genetic ancestry effects on the response to viral infection are pervasive but cell type specific","Genome-Wide DNA Hypermethylation in the Wound-Edge of Chronic Wound Patients Opposes Closure by Impairing Epithelial to Mesenchymal Transition","Genomic profiling of human spermatogonial stem cells","HCA seed network precise tumor-nephrectomy samples","Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing To Define Immune Cell Chimerism in the Rejecting Kidney Transplant","Healthy human kidney cell type single cell RNA-seq data","Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses","High throughput error corrected Nanopore single cell transcriptome sequencing.","High-Resolution Transcriptomic Landscape of the Human Submandibular Gland.","Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.","Human SARS-CoV-2 challenge resolves local and systemic response dynamics","Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.","Human distal airways contain a multipotent secretory cell that can regenerate alveoli","Human distal lung maps and lineage hierarchies reveal a bipotent progenitor","Human melanocyte development and melanoma dedifferentiation at single-cell resolution","Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity","Human photoreceptor cells from different macular subregions have distinct transcriptional profiles","Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution","Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19","Identification of a mesenchymal progenitor cell hierarchy in adipose tissue (scRNA-seq)","Identification of a unique subset of tissue-resident memory CD4+ T cells in Crohn’s disease","Identification of distinct synovial fibroblast subsets associated with pain and progression of knee osteoarthritis using single-cell RNA sequencing","Identification of neural oscillations and epileptiform changes in human brain organoids.","Immune cell profiling of preeclamptic pregnant and postpartum women by single-cell RNA sequencing","Immune landscape of viral- and carcinogen-drived head and neck cancer","Immune signatures underlying post-acute COVID-19 lung sequelae","Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19","Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19","Improving fibroblast characterization using single-cell RNA sequencing: an optimized tissue disaggregation and data processing pipeline.","In Vitro and In Vivo Development of the Human Airway at Single-Cell Resolution","Integrated analysis of multimodal single-cell data","Integrated multiomic characterization of congenital heart disease","Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes","Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis.","Integrated single-cell transcriptomics and epigenomics reveals strong germinal center–associated etiology of autoimmune risk loci","Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration","Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers","Integrative computational analysis of the substantia nigra pars compacta and the locus coeruleus","Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.","Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis.","Intrarenal Single-Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy.","Intratumoral heterogeneity in recurrent pediatric pilocytic astrocytomas","Joint profiling of chromatin accessibility and gene expression in thousands of single cells","Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells.","Kidney organoid reproducibility across multiple human iPSC lines and diminished off target cells after transplantation revealed by single cell transcriptomics","Lifespan charactarization of the nasal mucosa","Lineage recording in human cerebral organoids.","Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer.","Local and systemic responses to SARS-CoV-2 infection in children and adults","Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.","Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.","Lung transplantation for patients with severe COVID-19","Mapping Development of the Human Intestinal Niche at Single-Cell Resolution","Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer.","Mapping the developing human immune system across organs","Mapping the immune environment in clear cell renal carcinoma by single-cell genomics","Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro","Marked regional glial heterogeneity in the human white matter of the central nervous system","Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior","Melanoma infiltration of stromal and immune cells","Memory-like natural killer cells facilitate effector functions of daratumumab in multiple myeloma","Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.","Modeling Hepatoblastoma: Identification of Distinct Tumor Cell Populations and Key Genetic Mechanisms through Single Cell Sequencing (scRNA-seq)","Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids.","Molecular Architecture of the Mouse Nervous System.","Molecular and cellular evolution of the primate dorsolateral prefrontal cortex.","Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.","Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing","Molecular characterization of selectively vulnerable neurons in Alzheimer's disease.","Molecular signatures of inflammatory profile and B-cell function in SFTS patients","Molecular transitions in early progenitors during human cord blood hematopoiesis","Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways","Multi-scale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma","Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer","Multimodal single cell sequencing of human diabetic kidney disease implicates chromatin accessibility and genetic background in disease progression","Multiplexing droplet-based single cell RNA-sequencing using genetic barcodes","Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin","Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.","Nuclei multiplexing with barcoded antibodies for single-nucleus genomics.","Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis'","Organoid single-cell genomic atlas uncovers human-specific features of brain development","Pathogen-induced tissue-resident memory T &lt;sub&gt;H&lt;/sub&gt; 17 (T &lt;sub&gt;RM&lt;/sub&gt; 17) cells amplify autoimmune kidney disease","Phenotype molding of stromal cells in the lung tumor microenvironment","Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk.","Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.","Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis","Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation","Profiling of CD34+ cells from human bone marrow to understand hematopoiesis","Profiling of transcribed cis-regulatory elements in single cells.","Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis","Pseudo-temporal ordering of individual cells reveals regulators of differentiation","Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response.","RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes","RNA-Seq from human innate lymphoid cells (ILCs) transitional populations.","Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.","Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds.","Reconstructing the human first trimester fetal-maternal interface using single cell transcriptomics","Recruited macrophages elicit atrial fibrillation","Refining Colorectal Cancer Classification and Clinical Stratification Through a Single-Cell Atlas","Regenerative lineages and immune-mediated pruning in lung cancer metastasis","Resolving cellular and molecular diversity along the hippocampal anterior-to-posterior axis in humans","Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics","Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level","Retinal ganglion cell-specific genetic regulation in primary open angle glaucoma","Robust temporal map of human in vitro myelopoiesis using single-cell genomics.","SARS-CoV-2 infection of the oral cavity and saliva.","SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.","SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells","Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral chronic graft-versus-host disease.","Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment","Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor.","Single Cell Multiome Atlas of the Human Fetal Retina","Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology","Single Cell RNA-Seq Analysis Reveals  Fate Decision of Human Pre-cDC Determined  by Transcription Factor Competition","Single Cell RNA-Seq profiling human embryonic kidney cortex cells","Single Cell RNA-Seq profiling of human embryonic kidney outer and inner cortical cells and kidney organoid cells","Single Cell RNA-Sequencing of Human Limb Skeletal Muscle across Development and Myogenic Culture from Pluripotent Stem Cells","Single Cell RNAseq of primary pulmonary endothelial cells.","Single Cell, Single Nucleus and Spatial RNA Sequencing of the Human Liver Identifies Hepatic Stellate Cell and Cholangiocyte Heterogeneity","Single Nucleus RNA-sequencing Reveals Altered Intercellular Communication and Dendritic Cell Activation in Nonobstructive Hypertrophic Cardiomyopathy","Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","Single cell RNA sequencing of multiple myeloma II","Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis","Single cell RNA-Seq of E18.5 developing mouse kidney and human kidney organoids","Single cell RNA-seq analysis of adult and paediatric IDH-wildtype Glioblastomas","Single cell RNA-seq of HeLa CCL2","Single cell RNA-seq of brain glioblastoma samples","Single cell RNA-sequencing of human tonsil Innate lymphoid cells (ILCs)","Single cell RNA-sequencing on healthy and IPF lung mesenchymal cells.","Single cell RNAseq analysis of the developmental trajectory of iPSC-derived tenocytes","Single cell RNAseq of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium","Single cell analysis of endometriosis reveals a coordinated transcriptional program driving immunotolerance and angiogenesis across eutopic and ectopic tissues","Single cell analysis of human fetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors","Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure","Single cell atlas of the human retina","Single cell landscape of mesenchymal and endothelial cells in healthy human liver","Single cell profiling of COVID-19 patients: an international data resource from multiple tissues","Single cell profiling of human induced dendritic cells generated by direct reprogramming of embryonic fibroblasts","Single cell sequencing identifies novel sub-populations of breast cancer cells selected under hypoxia","Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney","Single cell transcriptional profiling of peripheral blood mononuclear cells (PBMCs) from mice flown on Rodent Research Reference Mission-2 (RRRM-2)","Single cell transcriptional profiling of spleens from mice flown on Rodent Research Reference Mission-2","Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells","Single cell transcriptome atlases of the developing mouse and human spinal cord.","Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease","Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker.","Single cell transcriptomics of human epidermis identifies basal stem cell transition states.","Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord","Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord.","Single nucleus and spatial transcriptomic profiling of human healthy hamstring tendon","Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms","Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns","Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer","Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes","Single-Cell Lymphocyte Heterogeneity in Advanced Cutaneous T-cell Lymphoma Skin Tumors","Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.","Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis.","Single-Cell RNA Sequencing Reveals Human iPS Cell-derived Alveolar Type 1 Cells in Alveolar Organoids","Single-Cell RNA Sequencing in Multiple Pathologic Types of Renal Cell Carcinoma Revealed Novel Potential Tumor-Specific Markers.","Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal- Niche Interactions","Single-Cell RNA-Seq 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22","Carnegie stage 23"],["human adult stage"],["human adult stage","juvenile stage"],["human adult stage"],["human adult stage"],["53-year-old human stage","64-year-old human stage","65-year-old human stage","66-year-old human stage","67-year-old human stage","68-year-old human stage","69-year-old human stage","73-year-old human stage","77-year-old human stage","78-year-old human stage","80 year-old and over human stage","80-year-old human stage","81-year-old human stage","82-year-old human stage","83-year-old human stage","84-year-old human stage","85-year-old human stage","86-year-old human stage","88-year-old human stage"],["human adult stage"],["adult"],["10th week post-fertilization human stage","12th week post-fertilization human stage","13th week post-fertilization human stage","14th week post-fertilization human stage","16th week post-fertilization human stage","17th week post-fertilization human stage","18th week post-fertilization human stage","20th week post-fertilization human stage","21st week post-fertilization human stage","human adult stage"],["40-year-old human stage","55-year-old human stage","65-year-old human stage","68-year-old human stage","71-year-old human stage","74-year-old human stage"],["human adult stage"],["adult","human adult stage","newborn human stage","postpartum"],["adult","child stage","human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["adult"],["child stage","infant","infant stage"],["embryonic human stage","fetal stage","human adult stage"],["embryonic human stage"],["human adult stage"],["human adult stage"],["13th week post-fertilization human stage","14-month-old human stage","16th week post-fertilization human stage","17th week post-fertilization human stage","18th week post-fertilization human stage","19-month-old human stage","19th week post-fertilization human stage","2-month-old human stage","2-year-old human stage","3-month-old human stage","5-month-old human stage","6-month-old human stage","newborn stage (0-28 days)"],["human adult stage"],["mature stage"],["fetal stage","human adult stage"],["adolescent stage","child stage","human adult stage"],["human adult stage"],["19-year-old human stage","21-year-old human stage","22-year-old human stage","23-year-old human stage","24-year-old human stage","25-year-old human stage","26-year-old human stage","27-year-old human stage","28-year-old human stage","29-year-old human stage","30-year-old human stage","31-year-old human stage","32-year-old human stage","33-year-old human stage","34-year-old human stage","35-year-old human stage","36-year-old human stage","37-year-old human stage","38-year-old human stage","39-year-old human stage","40-year-old human stage","41-year-old human stage","42-year-old human stage","43-year-old human stage","44-year-old human stage","45-year-old human stage","46-year-old human stage","47-year-old human stage","48-year-old human stage","49-year-old human stage","50-year-old human stage","51-year-old human stage","52-year-old human stage","53-year-old human stage","54-year-old human stage","55-year-old human stage","56-year-old human stage","57-year-old human stage","58-year-old human stage","59-year-old human stage","60-year-old human stage","61-year-old human stage","62-year-old human stage","63-year-old human stage","64-year-old human stage","65-year-old human stage","66-year-old human stage","68-year-old human stage","71-year-old human stage","73-year-old human stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["child stage","human adult stage"],["human adult stage"],["human adult stage"],["12th week post-fertilization human stage","15th week post-fertilization human stage","17th week post-fertilization human stage","19th week post-fertilization human stage","45-year-old human stage","50-year-old human stage","embryonic human stage"],["adult","child stage"],["human adult stage"],["adolescent stage","child stage","human adult stage"],["adult","human adult stage"],["embryonic human stage","fifth LMP month human stage","fourth LMP month human stage","human adult stage","newborn human stage","third LMP month human stage"],["human adult stage"],["human adult stage"],["infant stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["16th week post-fertilization human stage","human adult stage"],["30-year-old human stage","33-year-old human stage","41-year-old human stage","47-year-old human stage","65-year-old human stage","66-year-old human stage","67-year-old human stage","72-year-old human stage","77-year-old human stage","78-year-old human stage"],["human adult stage"],["human adult stage"],["human adult stage","infant stage"],["adult","human adult stage"],["embryonic human stage","human adult stage"],["28-year-old human stage","31-year-old human stage","37-year-old human stage"],["11th week post-fertilization human stage","17th week post-fertilization human stage","19th week post-fertilization human stage","2-5 year-old child stage","20th week post-fertilization human stage","9th week post-fertilization human stage","Carnegie stage 18","Carnegie stage 19","Carnegie stage 22","human adult stage","infant stage","newborn human stage"],["30-year-old human stage","31-year-old human stage","32-year-old human stage","34-year-old human stage","46-year-old human stage","52-year-old human stage"],["human adult stage"],["16th week post-fertilization human stage","18th week post-fertilization human stage","20th week post-fertilization human stage","22nd week post-fertilization human stage","25th week post-fertilization human stage","27th week post-fertilization human stage"],["human adult stage"],["adolescent stage","human adult stage","human aged stage","human middle aged stage","young adult stage"],["human adult stage"],["post-embryonic stage","sexually immature stage"],["human adult stage"],["adolescent stage","human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["embryonic human stage","fetal stage"],["human adult stage"],["human adult stage"],["10th week post-fertilization human stage","11th week post-fertilization human stage","12th week post-fertilization human stage","13th week post-fertilization human stage","14th week post-fertilization human stage","26th week post-fertilization human stage","Carnegie stage 19","human adult stage","infant stage"],["human adult stage"],["fully formed stage"],["human adult stage"],["human adult stage"],["human adult stage"],["Carnegie stage 10","Carnegie stage 11","Carnegie stage 12","Carnegie stage 14","Carnegie stage 18","Carnegie stage 20","Carnegie stage 22","Carnegie stage 23","fetal stage","human adult stage"],["10th week post-fertilization human stage","11th week post-fertilization human stage","12th week post-fertilization human stage","13th week post-fertilization human stage","15th week post-fertilization human stage","16th week post-fertilization human stage","17th week post-fertilization human stage","9th week post-fertilization human stage","Carnegie stage 14","Carnegie stage 23","organogenesis stage"],["post-embryonic stage"],["human adult stage","post-embryonic stage"],["human adult stage"],["adult"],["human adult stage"],["human adult stage"],["39-year-old human stage","40-year-old human stage","56-year-old human stage","65-year-old human stage"],["human adult stage"],["human adult stage"],["13th week post-fertilization human stage","14th week post-fertilization human stage","16th week post-fertilization human stage","19th week post-fertilization human stage","30-year-old human stage","embryonic human stage"],["human adult stage"],["human adult stage"],["fetal stage"],["child stage","human adult stage"],["Theiler stage 23","adult"],["human adult stage"],["human adult stage"],["child stage","embryonic human stage","fetal stage","infant stage"],["human adult stage","juvenile stage"],["human adult stage"],["human adult stage"],["human adult stage"],["adult","human adult stage"],["human adult stage"],["human adult stage","newborn human stage"],["human life cycle"],[],["human adult stage"],["fetal stage"],["fetal stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["43-year-old human stage","46-year-old human stage","50-year-old human stage","53-year-old human stage","57-year-old human stage","58-year-old human stage","59-year-old human stage","60-year-old human stage","67-year-old human stage","68-year-old human stage","69-year-old human stage","71-year-old human stage","72-year-old human stage","74-year-old human stage"],["human adult stage","human life cycle"],["30-year-old human stage","31-year-old human stage","35-year-old human stage","39-year-old human stage","40-year-old human stage","41-year-old human stage","42-year-old human stage","47-year-old human stage","48-year-old human stage","49-year-old human stage","52-year-old human stage","53-year-old human stage","56-year-old human stage","57-year-old human stage","66-year-old human stage"],["human adult stage"],["Theiler stage 26"],["human adult stage"],["Theiler stage 28"],["human adult stage"],["fetal stage","human adult stage"],["human adult stage"],["human adult stage"],["10th week post-fertilization human stage","12th week post-fertilization human stage","16th week post-fertilization human stage","18th week post-fertilization human stage","9-month-old human stage","9th week post-fertilization human stage","human adult stage"],["adult human stage"],["human adult stage"],["adolescent stage","adult stage","child stage","fetal stage","infant stage","newborn human stage"],["human adult stage"],["adult","human adult stage","infant"],["human adult stage"],["human adult stage"],["child stage","human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["12th week post-fertilization human stage","15th week post-fertilization human stage","18th week post-fertilization human stage","21st week post-fertilization human stage"],["human adult stage"],["human adult stage","immature stage","newborn human stage","young adult stage"],["10-month-old human stage","14-month-old human stage","5-month-old human stage","6-month-old human stage"],["human adult stage"],["child stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["child stage"],["adult","embryo stage","fetal stage","human adult stage"],["embryonic human stage"],["human adult stage","newborn human stage"],["2-5 year-old child stage","25-44 year-old human stage","6-12 year-old child stage","adolescent stage","child stage","human middle aged stage","under-1-year-old human stage","young adult stage"],["human adult stage"],["human adult stage"],["adolescent stage","child stage","human adult stage","human aged stage","infant stage","newborn human stage"],["human adult stage"],["fetal stage","infant stage"],["human adult stage"],["11th week post-fertilization human stage","12th week post-fertilization human stage","15th week post-fertilization human stage","18th week post-fertilization human stage","19th week post-fertilization human stage","9th week post-fertilization human stage","embryonic human stage"],["human adult stage"],["adult","embryonic human stage","fetal stage","human adult stage"],["human adult stage"],["human adult stage"],["34-year-old human stage","37-year-old human stage","39-year-old human stage","40-year-old human stage","42-year-old human stage","44-year-old human stage","45-year-old human stage","61-year-old human stage","63-year-old human stage","71-year-old human stage","72-year-old human stage","73-year-old human stage","74-year-old human stage"],["adult"],["adult"],["human adult stage"],["adult","child stage","human adult stage"],["human adult stage"],["human adult stage"],["Theiler stage 28"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["child stage","infant stage"],["human adult stage"],["human adult stage"],["51-year-old human stage","52-year-old human stage","53-year-old human stage","57-year-old human stage","59-year-old human stage","61-year-old human stage","74-year-old human stage","78-year-old human stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage","post-juvenile adult stage"],["human adult stage"],["embryonic human stage","human adult stage"],["human adult stage"],["human adult stage"],["neonate"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["1-month-old human stage","human adult stage"],["human adult stage"],["human adult stage"],["adult"],["human adult stage"],["child stage"],["human adult stage"],["child stage"],["10th week post-fertilization human stage","Carnegie stage 14","Carnegie stage 18","Carnegie stage 22","Carnegie stage 23","human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["adult","human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["adult","human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["adolescent stage","child stage","fetal stage","human adult stage"],["11th week post-fertilization human stage","12th week post-fertilization human stage","13th week post-fertilization human stage","14th week post-fertilization human stage","15th week post-fertilization human stage","17th week post-fertilization human stage","20th week post-fertilization human stage","21st week post-fertilization human stage","24th week post-fertilization human stage"],["human adult stage"],["human adult stage"],["fetal stage"],["fetal stage","human adult stage"],["6-12 year old child stage","embryonic human stage","fetal stage","human adult stage"],["human adult stage"],["41-year-old human stage","human adult stage","mature stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["Theiler stage 26","fetal stage"],["human adult stage","immature stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["under-1-year-old human stage"],["human adult stage"],["6-12 year old child stage","fetal stage","human adult stage"],["human adult stage","post-juvenile adult stage"],["53-year-old human stage","64-year-old human stage","65-year-old human stage","66-year-old human stage","67-year-old human stage","68-year-old human stage","69-year-old human stage","71-year-old human stage","73-year-old human stage","77-year-old human stage","80 year-old and over stage","80-year-old human stage","81-year-old human stage","82-year-old human stage","83-year-old human stage","85-year-old human stage","86-year-old human stage","88-year-old human stage"],["21-year-old human stage","39-year-old human stage","59-year-old human stage","60-year-old human stage","61-year-old human stage","62-year-old human stage","70-year-old human stage","71-year-old human stage","72-year-old human stage","80-year-old human stage","seventh decade human stage"],["human adult stage"],["Carnegie stage 18"],["human adult stage"],["50-year-old human stage","52-year-old human stage","54-year-old human stage","61-year-old human stage","62-year-old human stage"],["mouse postnatal"],["mouse postnatal"],["human adult stage"],["Carnegie stage 12","Carnegie stage 14","Carnegie stage 17","Carnegie stage 19","Theiler stage 13"],["adolescent stage","human adult stage"],["human adult stage"],["infant stage"],["embryo stage"],["juvenile days 45-89"],["18-year-old human stage","24-year-old human stage","26-year-old human stage","37-year-old human stage"],["child stage","human adult stage","human aged stage"],["1-month-old human stage","5-year-old human stage","6-year-old human stage","human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["human adult stage"],["adult","human adult stage"],["human adult stage"],["human adult stage"],["embryo stage"],["human adult stage"],["human adult stage"]]],"container":"<table class=\"display\">\n  <thead>\n    <tr>\n      <th> <\/th>\n      <th>projectId<\/th>\n      <th>projectTitle<\/th>\n      <th>genusSpecies<\/th>\n      <th>sampleEntityType<\/th>\n      <th>specimenOrgan<\/th>\n      <th>specimenOrganPart<\/th>\n      <th>selectedCellType<\/th>\n      <th>libraryConstructionApproach<\/th>\n      <th>nucleicAcidSource<\/th>\n      <th>pairedEnd<\/th>\n      <th>workflow<\/th>\n      <th>specimenDisease<\/th>\n      <th>donorDisease<\/th>\n      <th>developmentStage<\/th>\n    <\/tr>\n  <\/thead>\n<\/table>","options":{"columnDefs":[{"orderable":false,"targets":0},{"name":" ","targets":0},{"name":"projectId","targets":1},{"name":"projectTitle","targets":2},{"name":"genusSpecies","targets":3},{"name":"sampleEntityType","targets":4},{"name":"specimenOrgan","targets":5},{"name":"specimenOrganPart","targets":6},{"name":"selectedCellType","targets":7},{"name":"libraryConstructionApproach","targets":8},{"name":"nucleicAcidSource","targets":9},{"name":"pairedEnd","targets":10},{"name":"workflow","targets":11},{"name":"specimenDisease","targets":12},{"name":"donorDisease","targets":13},{"name":"developmentStage","targets":14}],"order":[],"autoWidth":false,"orderClasses":false},"selection":{"mode":"multiple","selected":null,"target":"row","selectable":null}},"evals":[],"jsHooks":[]}</script>
 </div>
 <div class="section level4">
 <h4 id="picking-a-project-enumerating-and-downloading-loom-files">Picking a project; Enumerating and downloading loom files<a class="anchor" aria-label="anchor" href="#picking-a-project-enumerating-and-downloading-loom-files"></a>
@@ -147,7 +135,7 @@ <h4 id="working-with-loom">Working with loom<a class="anchor" aria-label="anchor
 <p>Very superficial filtering (to 60000 cells) and development of PCA</p>
 <div class="sourceCode" id="cb5"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">LoomExperiment</span><span class="op">)</span></span>
-<span><span class="va">f1</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/BiocIO/man/IO.html" class="external-link">import</a></span><span class="op">(</span><span class="st">"/home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom"</span><span class="op">)</span></span>
+<span><span class="va">f1</span> <span class="op">=</span> <span class="fu">import</span><span class="op">(</span><span class="st">"/home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom"</span><span class="op">)</span></span>
 <span><span class="va">f1</span></span>
 <span><span class="fu"><a href="https://rdrr.io/r/base/names.html" class="external-link">names</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/SummarizedExperiment/man/SummarizedExperiment-class.html" class="external-link">colData</a></span><span class="op">(</span><span class="va">f1</span><span class="op">)</span><span class="op">)</span></span>
 <span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="http://bioconductor.org/packages/scater/" class="external-link">scater</a></span><span class="op">)</span></span>
@@ -164,40 +152,11 @@ <h4 id="working-with-loom">Working with loom<a class="anchor" aria-label="anchor
 <span><span class="fu"><a href="https://rdrr.io/pkg/SummarizedExperiment/man/SummarizedExperiment-class.html" class="external-link">assay</a></span><span class="op">(</span><span class="va">litsf2</span><span class="op">)</span></span>
 <span><span class="va">litsf2</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/scuttle/man/logNormCounts.html" class="external-link">logNormCounts</a></span><span class="op">(</span><span class="va">litsf2</span><span class="op">)</span></span>
 <span><span class="va">litsf2</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/BiocSingular/man/runPCA.html" class="external-link">runPCA</a></span><span class="op">(</span><span class="va">litsf2</span><span class="op">)</span></span></code></pre></div>
-<p>Whatchaget:</p>
+<p>This code is blocked until a bucket is made available with the filtered data.</p>
 <div class="sourceCode" id="cb6"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va">SingleCellExperiment</span><span class="op">)</span></span>
 <span><span class="kw">if</span> <span class="op">(</span><span class="op">!</span><span class="fu"><a href="https://rdrr.io/r/base/exists.html" class="external-link">exists</a></span><span class="op">(</span><span class="st">"litsf2"</span><span class="op">)</span><span class="op">)</span> <span class="fu"><a href="https://rdrr.io/r/base/load.html" class="external-link">load</a></span><span class="op">(</span><span class="st">"litsf2.rda"</span><span class="op">)</span> <span class="co"># run code above, must have HDF5 in cache</span></span>
-<span><span class="fu"><a href="https://rdrr.io/pkg/S4Vectors/man/Annotated-class.html" class="external-link">metadata</a></span><span class="op">(</span><span class="va">litsf2</span><span class="op">)</span></span></code></pre></div>
-<pre><code><span><span class="co">## $last_modified</span></span>
-<span><span class="co">## [1] "20210616T032315.280827Z"</span></span>
-<span><span class="co">## </span></span>
-<span><span class="co">## $CreationDate</span></span>
-<span><span class="co">## [1] "20210616T030548.106180Z"</span></span>
-<span><span class="co">## </span></span>
-<span><span class="co">## $LOOM_SPEC_VERSION</span></span>
-<span><span class="co">## [1] "3.0.0"</span></span>
-<span><span class="co">## </span></span>
-<span><span class="co">## $expression_data_type</span></span>
-<span><span class="co">## [1] "exonic"</span></span>
-<span><span class="co">## </span></span>
-<span><span class="co">## $input_id</span></span>
-<span><span class="co">## [1] "5012cf4f-ba5c-4928-aea1-ab2891e34323"</span></span>
-<span><span class="co">## </span></span>
-<span><span class="co">## $input_id_metadata_field</span></span>
-<span><span class="co">## [1] "sequencing_process.provenance.document_id"</span></span>
-<span><span class="co">## </span></span>
-<span><span class="co">## $input_name</span></span>
-<span><span class="co">## [1] "D27PrTzF_Edn"</span></span>
-<span><span class="co">## </span></span>
-<span><span class="co">## $input_name_metadata_field</span></span>
-<span><span class="co">## [1] "sequencing_input.biomaterial_core.biomaterial_id"</span></span>
-<span><span class="co">## </span></span>
-<span><span class="co">## $optimus_output_schema_version</span></span>
-<span><span class="co">## [1] "1.0.0"</span></span>
-<span><span class="co">## </span></span>
-<span><span class="co">## $pipeline_version</span></span>
-<span><span class="co">## [1] "Optimus_v4.2.3"</span></span></code></pre>
+<span><span class="fu"><a href="https://pkgs.rstudio.com/rmarkdown/reference/metadata.html" class="external-link">metadata</a></span><span class="op">(</span><span class="va">litsf2</span><span class="op">)</span></span></code></pre></div>
 <pre><code>&gt; str(litsf2) # 22MB on disk (no quantifications)
 Formal class 'DelayedMatrix' [package "DelayedArray"] with 1 slot
   ..@ seed:Formal class 'DelayedAperm' [package "DelayedArray"] with 2 slots
@@ -225,10 +184,10 @@ <h4 id="working-with-isee">Working with iSEE<a class="anchor" aria-label="anchor
 <li>Question: can we embed iSEE (or components) in a vignette? Or is there an iSEE server?</li>
 </ul>
 <div class="figure">
-<img src="isee2.jpg" alt="context"><p class="caption">context</p>
+<img src="isee2.jpg" alt=""><p class="caption">context</p>
 </div>
 <div class="figure">
-<img src="isee1.jpg" alt="fgf2"><p class="caption">fgf2</p>
+<img src="isee1.jpg" alt=""><p class="caption">fgf2</p>
 </div>
 </div>
 </div>
@@ -277,29 +236,29 @@ <h3 id="rols-basic-idea">rols: Basic idea<a class="anchor" aria-label="anchor" h
 <div class="section level3">
 <h3 id="learn-about-smooth-muscle-with-rols">Learn about ‘smooth muscle’ with rols<a class="anchor" aria-label="anchor" href="#learn-about-smooth-muscle-with-rols"></a>
 </h3>
-<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r">
-<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="http://lgatto.github.com/rols/" class="external-link">rols</a></span><span class="op">)</span></span>
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+<code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="http://lgatto.github.io/rols/" class="external-link">rols</a></span><span class="op">)</span></span>
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 <span><span class="va">ss</span></span></code></pre></div>
 <pre><code><span><span class="co">## Object of class 'OlsSearch':</span></span>
 <span><span class="co">##   query: smooth muscle </span></span>
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 <span><span class="co">##   response(s): 0</span></span></code></pre>
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 <span><span class="va">dd</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/methods/as.html" class="external-link">as</a></span><span class="op">(</span><span class="va">tt</span>, <span class="st">"data.frame"</span><span class="op">)</span></span>
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Found within the walls of blood vessels, the alimentary tract, bladder, and reproductive tract."],["Muscle tissue that lacks cross striations, that is made up of elongated spindle-shaped cells having a central nucleus, and that is found in vertebrate visceral structures (as the stomach and bladder) as thin sheets performing functions not subject to conscious control by the mind and in all or most of the musculature of invertebrates other than arthropods."],["A non-striated muscle that is composed of spindle-shaped cells.  Smooth muscle usually is organized into sheets that line cavitated organs."],["Muscle tissue that lacks cross striations, that is made up of elongated spindle-shaped cells having a central nucleus, and that is found in vertebrate visceral structures (as the stomach and bladder) as thin sheets performing functions not subject to conscious control by the mind and in all or most of the musculature of invertebrates other than arthropods.","Visceral muscle of the adult."],["Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers. Found within the walls of blood vessels, the alimentary tract, bladder, and reproductive tract."],["A non-striated muscle that is composed of spindle-shaped cells.  Smooth muscle usually is organized into sheets that line cavitated organs."],null,null,["Involuntary muscle tissue of the internal organs. It is composed of elongated muscle cells or fibers that are not arranged in a striated pattern and form layers of muscle tissue. The smooth muscle cells contain a contractile apparatus composed of thin and thick filaments and a cytoskeleton composed of intermediate filaments."],null,null,["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. 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Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],null,["Tissue which consists of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers.  Examples: Arrector muscle of hair, Muscularis mucosae."],null,null,null,null,null,null,null,null,null,null,null,["Muscle cell which has as its direct parts myofilaments attached to cytoplasmic dense bodies."],null,["Epithelial cell containing smooth myofibers."],["Smooth muscle of the subumbrella."],null,null,null,null,["Any unspecified morphological anomaly of the smooth muscle, such as, for example, abnormal shape or colour."],["An abnormally necrotic smooth muscle."],["Absence of smooth muscle myocyte."],["Abnormality of smooth muscle myocyte."],["Absence of smooth muscle."],["Abnormality of smooth muscle."],["An abnormally localised smooth muscle."],null,null,null,null,["A ring of smooth muscle cells whose contraction closes the opening of the ring."],["A tissue composed of smooth muscle cells."],["A myocyte of the smooth muscle."],null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null],["xao","bto","zfa","efo","xpo","zp","wbbt","wbphenotype","ncit","omit","uberon","ohpi","nbo","envo","flopo","fovt","zp","ecocore","clo","oae","rbo","wbphenotype","dpo","mp","pato","ms","pcl","efo","maxo","hcao","ecto","emapa","fma","omit","omit","omit","omit","omit","fma","fma","fma","fma","fma","fma","fma","fma","clyh","clyh","cteno","hpath","hpath","hpath","xpo","xpo","xpo","xpo","xpo","xpo","xpo","snomed","snomed","snomed","snomed","aeo","aeo","xao","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma","ma"],["XAO","BTO","ZFA","EFO","XPO","ZP","WBbt","WBPhenotype","NCIT","OMIT","UBERON","OHPI","NBO","ENVO","FLOPO","FOVT","ZP","ECOCORE","CLO","OAE","RBO","WBPhenotype","FBcv","MP","PATO","MS","PCL","EFO","MAXO","HCAO","ECTO","EMAPA","FMA","OMIT","OMIT","OMIT","OMIT","OMIT","FMA","FMA","FMA","FMA","FMA","FMA","FMA","FMA","CLYH","CLYH","CTENO","MC","MC","MC","XPO","XPO","XPO","XPO","XPO","XPO","XPO","SNOMED","SNOMED","SNOMED","SNOMED","AEO","AEO","XAO","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA","MA"],["class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class"],[true,true,true,true,false,false,false,false,true,true,true,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,false,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true,true]],"container":"<table class=\"display\">\n  <thead>\n    <tr>\n      <th> <\/th>\n      <th>id<\/th>\n      <th>iri<\/th>\n      <th>short_form<\/th>\n      <th>obo_id<\/th>\n      <th>label<\/th>\n      <th>description<\/th>\n      <th>ontology_name<\/th>\n      <th>ontology_prefix<\/th>\n      <th>type<\/th>\n      <th>is_defining_ontology<\/th>\n    <\/tr>\n  <\/thead>\n<\/table>","options":{"columnDefs":[{"orderable":false,"targets":0}],"order":[],"autoWidth":false,"orderClasses":false},"selection":{"mode":"multiple","selected":null,"target":"row","selectable":null}},"evals":[],"jsHooks":[]}</script>
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tissue that lacks cross striations, that is made up of elongated spindle-shaped cells having a central nucleus, and that is found in vertebrate visceral structures (as the stomach and bladder) as thin sheets performing functions not subject to conscious control by the mind and in all or most of the musculature of invertebrates other than arthropods."],["A non-striated muscle that is composed of spindle-shaped cells.  Smooth muscle usually is organized into sheets that line cavitated organs."],["Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers. Found within the walls of blood vessels, the alimentary tract, bladder, and reproductive tract."],[],["Muscle tissue that lacks cross striations, that is made up of elongated spindle-shaped cells having a central nucleus, and that is found in vertebrate visceral structures (as the stomach and bladder) as thin sheets performing functions not subject to conscious control by the mind and in all or most of the musculature of invertebrates other than arthropods.","Visceral muscle of the adult."],[],["Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers. Found within the walls of blood vessels, the alimentary tract, bladder, and reproductive tract."],[],["A non-striated muscle that is composed of spindle-shaped cells.  Smooth muscle usually is organized into sheets that line cavitated organs."],["Muscle tissue that lacks cross striations, that is made up of elongated spindle-shaped cells having a central nucleus, and that is found in vertebrate visceral structures (as the stomach and bladder) as thin sheets performing functions not subject to conscious control by the mind and in all or most of the musculature of invertebrates other than arthropods.","Visceral muscle of the adult."],["Muscle cell of a muscle that moves the viscera and has only one or, commonly no attachment to the body wall. Visceral muscles differ from somatic muscles in several respects: adjacent fibers are held together by desmosomes, each fiber is uninucleate and the contractile material is not grouped into fibrils but packs the whole fiber. Visceral muscles appear striated. The visceral musculature comprises circular and longitudinal fibers which surround the entire intestinal tract, with the exception of the recurrent layer of the proventriculus, and ducts of the reproductive system. The circular fibers derive from a bilaterally symmetrical band of mesodermal cells extending continuously throughout most of the germ band. The longitudinal fibers derive from clusters of mesodermal cells which appear during stage 12 at the posterior end of the embryo and migrate anteriorly.","It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however most visceral muscles in Drosophila are actually striated (Bate, 1993 - FBrf0064793)."],["Involuntary muscle tissue of the internal organs. It is composed of elongated muscle cells or fibers that are not arranged in a striated pattern and form layers of muscle tissue. The smooth muscle cells contain a contractile apparatus composed of thin and thick filaments and a cytoskeleton composed of intermediate filaments."],["Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]."],["A smooth muscle cell of the bladder."],[],["A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)."],[],[],[],[],[],[],["A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)."],["A precursor cell destined to differentiate into smooth muscle myocytes."],[],["Epithelial cell containing smooth myofibers."],["Smooth muscle of the subumbrella."],[],[],["Smooth muscle that is present continuously around the bronchi."],["Muscle tissue that lacks cross striations, that is made up of elongated spindle-shaped cells having a central nucleus, and that is found in vertebrate visceral structures (as the stomach and bladder) as thin sheets performing functions not subject to conscious control by the mind and in all or most of the musculature of invertebrates other than arthropods."],[],[],[],["The inner layer of the muscular coat."],["The outer layer of the muscular coat."],["The smooth muscle of the ileums walls is thinner than the walls of other parts of the intestines, and its peristaltic contractions are slower."],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],["A benign or malignant myomatous neoplasm arising from smooth muscle."],[],[],[],[],[],[],[],[],[],[],[],[],[],[],[],["Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities."],["A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ."],["A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse."],["The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy."],["A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length."],[],["A malignant neoplasm arising from smooth muscle."],["A group of autoimmune substances found in the smooth muscles that may be comprised of (but not limited to) actin and non-actin cytoskeleton components such as vimentin, tubulin, and desmin. They are commonly associated with autoimmune hepatitis."],[],[],[],[],[],[],["A benign or malignant myomatous neoplasm arising from smooth muscle."],["Smooth muscle that is part of the blood vessel wall."],["A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)."],["A precursor cell destined to differentiate into smooth muscle myocytes."],["Abnormality of smooth muscle."],["Absence of smooth muscle."]],["smooth muscle","smooth muscle","smooth muscle","smooth muscle","smooth muscle","smooth muscle","smooth muscle","smooth muscle","smooth muscle","smooth muscle","visceral muscle cell","Smooth Muscle Tissue","smooth muscle tissue","smooth muscle","Muscle, Smooth","Smooth muscle cell","Smooth muscle tumor (morphologic abnormality)","ureteral smooth muscle layer smooth muscle component","Smooth muscle antibody","Smooth muscle spasm","Smooth muscle relaxant","Smooth muscle relaxant","smooth muscle cell","smooth muscle myoblast","giant smooth muscle","smooth muscle cell","subumbrella smooth muscle","smooth muscle cancer","smooth muscle tumor","bronchial smooth muscle","smooth muscle cell","vaginal smooth muscle","clitoral smooth muscle","gastrointestinal smooth muscle","circular smooth muscle","longitudinal smooth muscle","ileum smooth muscle","smooth adductor muscle","arterial smooth muscle","gizzard smooth muscle","iris smooth muscle","tracheal smooth muscle","vascular smooth muscle","respiratory smooth muscle","aortic smooth muscle","stomach smooth muscle","umbilical smooth muscle","smooth muscle tissue","aorta smooth muscle","arteriole smooth muscle","artery smooth muscle","spleen smooth muscle","ocular smooth muscle","iris smooth muscle","intestine smooth muscle","esophagus smooth muscle","stomach smooth muscle","urethra smooth muscle","oviduct smooth muscle","vagina smooth muscle","epididymis smooth muscle","bronchus smooth muscle","trachea smooth muscle","alveolar smooth muscle","smooth muscle tumor","eye smooth muscle","trachea smooth muscle","smooth muscle tissue","alveolus smooth muscle","aorta smooth muscle","bronchus smooth muscle","esophagus smooth muscle","gallbladder smooth muscle","intestine smooth muscle","spleen smooth muscle","stomach smooth muscle","artery smooth muscle","arteriole smooth muscle","vein smooth muscle","bronchiole smooth muscle","smooth muscle adaptation","smooth muscle hyperplasia","smooth muscle atrophy","smooth muscle hypertrophy","smooth muscle contraction","pelvic smooth muscle","smooth muscle cancer","Smooth Muscle Autoantigen","Muscle, Smooth, Vascular","Smooth Muscle Tumor","Smooth Muscle Myosins","Myocytes, Smooth Muscle","Myoblasts, Smooth Muscle","Mouse Smooth Muscle","Smooth Muscle Neoplasm","vascular smooth muscle","smooth muscle cell","smooth muscle myoblast","abnormal smooth muscle","absent smooth muscle"],["BTO:0001260","ZFA:0005274","XAO:0000175","WBbt:0005781","EFO:0000889","ZFA:0005274","XAO:0000175","WBbt:0005781","TAO:0005274","EFO:0000889","FBbt:00005070","NCIT:C12437","UBERON:0001135","CL:0002597","OMIT:0010170","CL:0000192","SNOMED:75109009","EMAPA:28814","SNOMED:121122009","SNOMED:128526009","SNOMED:90000002","SNOMED:372894003","CL:0000192","CL:0000514","CTENO:0000037","CLYH:1000121","CLYH:1000123","DOID:4230","DOID:4310","BTO:0004401","BTO:0004576","BTO:0004999","BTO:0005000","BTO:0005024","BTO:0005213","BTO:0005214","BTO:0005574","BTO:0006174","BTO:0000087","BTO:0000521","BTO:0000655","BTO:0001391","BTO:0001431","BTO:0001660","BTO:0001685","BTO:0001818","BTO:0001847","MA:0000166","MA:0000702","MA:0000706","MA:0000708","MA:0000757","MA:0001268","MA:0001270","MA:0001539","MA:0001573","MA:0001627","MA:0001691","MA:0001721","MA:0001733","MA:0001736","MA:0001840","MA:0001863","MA:0002759","MONDO:0006975","EMAPA:18807","EMAPA:19192","EMAPA:32717","EMAPA:35122","EMAPA:35135","EMAPA:35195","EMAPA:35323","EMAPA:35373","EMAPA:35443","EMAPA:35807","EMAPA:35823","EMAPA:36285","EMAPA:36287","EMAPA:36289","EMAPA:36339","GO:0014805","GO:0014806","GO:0014890","GO:0014895","GO:0006939","EMAPA:28120","MONDO:0002924","NCIT:C198274","OMIT:0010171","OMIT:0018468","OMIT:0021087","OMIT:0022300","OMIT:0022301","NCIT:C22693","NCIT:C3751","ZFA:0005321","ZFA:0009118","ZFA:0009235","XPO:0100746","XPO:0124964"],["class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class","class"]],"container":"<table class=\"display\">\n  <thead>\n    <tr>\n      <th> <\/th>\n      <th>iri<\/th>\n      <th>ontology_name<\/th>\n      <th>ontology_prefix<\/th>\n      <th>short_form<\/th>\n      <th>description<\/th>\n      <th>label<\/th>\n      <th>obo_id<\/th>\n      <th>type<\/th>\n    <\/tr>\n  <\/thead>\n<\/table>","options":{"columnDefs":[{"orderable":false,"targets":0},{"name":" ","targets":0},{"name":"iri","targets":1},{"name":"ontology_name","targets":2},{"name":"ontology_prefix","targets":3},{"name":"short_form","targets":4},{"name":"description","targets":5},{"name":"label","targets":6},{"name":"obo_id","targets":7},{"name":"type","targets":8}],"order":[],"autoWidth":false,"orderClasses":false},"selection":{"mode":"multiple","selected":null,"target":"row","selectable":null}},"evals":[],"jsHooks":[]}</script>
 </div>
 <div class="section level3">
 <h3 id="ontoproc-capitalizing-on-ontologyindex-thanks-daniel-greene-rgraphviz-thanks-kasper-hansen">ontoProc – capitalizing on ontologyIndex (thanks Daniel Greene!), Rgraphviz (thanks Kasper Hansen!)<a class="anchor" aria-label="anchor" href="#ontoproc-capitalizing-on-ontologyindex-thanks-daniel-greene-rgraphviz-thanks-kasper-hansen"></a>
 </h3>
-<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/vjcitn/ontoProc" class="external-link">ontoProc</a></span><span class="op">)</span></span>
 <span><span class="va">co</span> <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/pkg/ontoProc/man/getOnto.html" class="external-link">getOnto</a></span><span class="op">(</span><span class="st">"cellOnto"</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">## loading from cache</span></span></code></pre>
-<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/utils/head.html" class="external-link">head</a></span><span class="op">(</span><span class="va">co</span><span class="op">$</span><span class="va">name</span><span class="op">)</span></span></code></pre></div>
 <pre><code><span><span class="co">##              BFO:0000002              BFO:0000003              BFO:0000004 </span></span>
 <span><span class="co">##             "continuant"              "occurrent" "independent continuant" </span></span>
@@ -315,28 +274,26 @@ <h3 id="ontoproc-capitalizing-on-ontologyindex-thanks-daniel-greene-rgraphviz-th
 <h2 id="shinywow2---check-out-vjcitn-shinyapps-iotnt4dn8-but-be-patient-and-dont-do-it-while-i-am-doing-it">shinywow2 - check out vjcitn.shinyapps.io/tnt4dn8 but be patient and don’t do it while i am doing it …<a class="anchor" aria-label="anchor" href="#shinywow2---check-out-vjcitn-shinyapps-iotnt4dn8-but-be-patient-and-dont-do-it-while-i-am-doing-it"></a>
 </h2>
 </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside>
 </div>
 
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
 </div>
 
     </footer>
 </div>
 
-  
 
-  
+
+
 
   </body>
 </html>
diff --git a/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/css/crosstalk.min.css b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/css/crosstalk.min.css
new file mode 100644
index 0000000..6b45382
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/css/crosstalk.min.css
@@ -0,0 +1 @@
+.container-fluid.crosstalk-bscols{margin-left:-30px;margin-right:-30px;white-space:normal}body>.container-fluid.crosstalk-bscols{margin-left:auto;margin-right:auto}.crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column{display:inline-block;padding-right:12px;vertical-align:top}@media only screen and (max-width: 480px){.crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column{display:block;padding-right:inherit}}.crosstalk-input{margin-bottom:15px}.crosstalk-input .control-label{margin-bottom:0;vertical-align:middle}.crosstalk-input input[type="checkbox"]{margin:4px 0 0;margin-top:1px;line-height:normal}.crosstalk-input .checkbox{position:relative;display:block;margin-top:10px;margin-bottom:10px}.crosstalk-input .checkbox>label{padding-left:20px;margin-bottom:0;font-weight:400;cursor:pointer}.crosstalk-input .checkbox input[type="checkbox"],.crosstalk-input .checkbox-inline input[type="checkbox"]{position:absolute;margin-top:2px;margin-left:-20px}.crosstalk-input .checkbox+.checkbox{margin-top:-5px}.crosstalk-input .checkbox-inline{position:relative;display:inline-block;padding-left:20px;margin-bottom:0;font-weight:400;vertical-align:middle;cursor:pointer}.crosstalk-input .checkbox-inline+.checkbox-inline{margin-top:0;margin-left:10px}
diff --git a/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/js/crosstalk.js b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/js/crosstalk.js
new file mode 100644
index 0000000..fd9eb53
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/js/crosstalk.js
@@ -0,0 +1,1474 @@
+(function(){function e(t,n,r){function s(o,u){if(!n[o]){if(!t[o]){var a=typeof require=="function"&&require;if(!u&&a)return a(o,!0);if(i)return i(o,!0);var f=new Error("Cannot find module '"+o+"'");throw f.code="MODULE_NOT_FOUND",f}var l=n[o]={exports:{}};t[o][0].call(l.exports,function(e){var n=t[o][1][e];return s(n?n:e)},l,l.exports,e,t,n,r)}return n[o].exports}var i=typeof require=="function"&&require;for(var o=0;o<r.length;o++)s(r[o]);return s}return e})()({1:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+var Events = function () {
+  function Events() {
+    _classCallCheck(this, Events);
+
+    this._types = {};
+    this._seq = 0;
+  }
+
+  _createClass(Events, [{
+    key: "on",
+    value: function on(eventType, listener) {
+      var subs = this._types[eventType];
+      if (!subs) {
+        subs = this._types[eventType] = {};
+      }
+      var sub = "sub" + this._seq++;
+      subs[sub] = listener;
+      return sub;
+    }
+
+    // Returns false if no match, or string for sub name if matched
+
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      var subs = this._types[eventType];
+      if (typeof listener === "function") {
+        for (var key in subs) {
+          if (subs.hasOwnProperty(key)) {
+            if (subs[key] === listener) {
+              delete subs[key];
+              return key;
+            }
+          }
+        }
+        return false;
+      } else if (typeof listener === "string") {
+        if (subs && subs[listener]) {
+          delete subs[listener];
+          return listener;
+        }
+        return false;
+      } else {
+        throw new Error("Unexpected type for listener");
+      }
+    }
+  }, {
+    key: "trigger",
+    value: function trigger(eventType, arg, thisObj) {
+      var subs = this._types[eventType];
+      for (var key in subs) {
+        if (subs.hasOwnProperty(key)) {
+          subs[key].call(thisObj, arg);
+        }
+      }
+    }
+  }]);
+
+  return Events;
+}();
+
+exports.default = Events;
+
+},{}],2:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+exports.FilterHandle = undefined;
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _events = require("./events");
+
+var _events2 = _interopRequireDefault(_events);
+
+var _filterset = require("./filterset");
+
+var _filterset2 = _interopRequireDefault(_filterset);
+
+var _group = require("./group");
+
+var _group2 = _interopRequireDefault(_group);
+
+var _util = require("./util");
+
+var util = _interopRequireWildcard(_util);
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+function getFilterSet(group) {
+  var fsVar = group.var("filterset");
+  var result = fsVar.get();
+  if (!result) {
+    result = new _filterset2.default();
+    fsVar.set(result);
+  }
+  return result;
+}
+
+var id = 1;
+function nextId() {
+  return id++;
+}
+
+/**
+ * Use this class to contribute to, and listen for changes to, the filter set
+ * for the given group of widgets. Filter input controls should create one
+ * `FilterHandle` and only call {@link FilterHandle#set}. Output widgets that
+ * wish to displayed filtered data should create one `FilterHandle` and use
+ * the {@link FilterHandle#filteredKeys} property and listen for change
+ * events.
+ *
+ * If two (or more) `FilterHandle` instances in the same webpage share the
+ * same group name, they will contribute to a single "filter set". Each
+ * `FilterHandle` starts out with a `null` value, which means they take
+ * nothing away from the set of data that should be shown. To make a
+ * `FilterHandle` actually remove data from the filter set, set its value to
+ * an array of keys which should be displayed. Crosstalk will aggregate the
+ * various key arrays by finding their intersection; only keys that are
+ * present in all non-null filter handles are considered part of the filter
+ * set.
+ *
+ * @param {string} [group] - The name of the Crosstalk group, or if none,
+ *   null or undefined (or any other falsy value). This can be changed later
+ *   via the {@link FilterHandle#setGroup} method.
+ * @param {Object} [extraInfo] - An object whose properties will be copied to
+ *   the event object whenever an event is emitted.
+ */
+
+var FilterHandle = exports.FilterHandle = function () {
+  function FilterHandle(group, extraInfo) {
+    _classCallCheck(this, FilterHandle);
+
+    this._eventRelay = new _events2.default();
+    this._emitter = new util.SubscriptionTracker(this._eventRelay);
+
+    // Name of the group we're currently tracking, if any. Can change over time.
+    this._group = null;
+    // The filterSet that we're tracking, if any. Can change over time.
+    this._filterSet = null;
+    // The Var we're currently tracking, if any. Can change over time.
+    this._filterVar = null;
+    // The event handler subscription we currently have on var.on("change").
+    this._varOnChangeSub = null;
+
+    this._extraInfo = util.extend({ sender: this }, extraInfo);
+
+    this._id = "filter" + nextId();
+
+    this.setGroup(group);
+  }
+
+  /**
+   * Changes the Crosstalk group membership of this FilterHandle. If `set()` was
+   * previously called on this handle, switching groups will clear those keys
+   * from the old group's filter set. These keys will not be applied to the new
+   * group's filter set either. In other words, `setGroup()` effectively calls
+   * `clear()` before switching groups.
+   *
+   * @param {string} group - The name of the Crosstalk group, or null (or
+   *   undefined) to clear the group.
+   */
+
+
+  _createClass(FilterHandle, [{
+    key: "setGroup",
+    value: function setGroup(group) {
+      var _this = this;
+
+      // If group is unchanged, do nothing
+      if (this._group === group) return;
+      // Treat null, undefined, and other falsy values the same
+      if (!this._group && !group) return;
+
+      if (this._filterVar) {
+        this._filterVar.off("change", this._varOnChangeSub);
+        this.clear();
+        this._varOnChangeSub = null;
+        this._filterVar = null;
+        this._filterSet = null;
+      }
+
+      this._group = group;
+
+      if (group) {
+        group = (0, _group2.default)(group);
+        this._filterSet = getFilterSet(group);
+        this._filterVar = (0, _group2.default)(group).var("filter");
+        var sub = this._filterVar.on("change", function (e) {
+          _this._eventRelay.trigger("change", e, _this);
+        });
+        this._varOnChangeSub = sub;
+      }
+    }
+
+    /**
+     * Combine the given `extraInfo` (if any) with the handle's default
+     * `_extraInfo` (if any).
+     * @private
+     */
+
+  }, {
+    key: "_mergeExtraInfo",
+    value: function _mergeExtraInfo(extraInfo) {
+      return util.extend({}, this._extraInfo ? this._extraInfo : null, extraInfo ? extraInfo : null);
+    }
+
+    /**
+     * Close the handle. This clears this handle's contribution to the filter set,
+     * and unsubscribes all event listeners.
+     */
+
+  }, {
+    key: "close",
+    value: function close() {
+      this._emitter.removeAllListeners();
+      this.clear();
+      this.setGroup(null);
+    }
+
+    /**
+     * Clear this handle's contribution to the filter set.
+     *
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any options that were
+     *   passed into the `FilterHandle` constructor).
+     * 
+     * @fires FilterHandle#change
+     */
+
+  }, {
+    key: "clear",
+    value: function clear(extraInfo) {
+      if (!this._filterSet) return;
+      this._filterSet.clear(this._id);
+      this._onChange(extraInfo);
+    }
+
+    /**
+     * Set this handle's contribution to the filter set. This array should consist
+     * of the keys of the rows that _should_ be displayed; any keys that are not
+     * present in the array will be considered _filtered out_. Note that multiple
+     * `FilterHandle` instances in the group may each contribute an array of keys,
+     * and only those keys that appear in _all_ of the arrays make it through the
+     * filter.
+     *
+     * @param {string[]} keys - Empty array, or array of keys. To clear the
+     *   filter, don't pass an empty array; instead, use the
+     *   {@link FilterHandle#clear} method.
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any options that were
+     *   passed into the `FilterHandle` constructor).
+     * 
+     * @fires FilterHandle#change
+     */
+
+  }, {
+    key: "set",
+    value: function set(keys, extraInfo) {
+      if (!this._filterSet) return;
+      this._filterSet.update(this._id, keys);
+      this._onChange(extraInfo);
+    }
+
+    /**
+     * @return {string[]|null} - Either: 1) an array of keys that made it through
+     *   all of the `FilterHandle` instances, or, 2) `null`, which means no filter
+     *   is being applied (all data should be displayed).
+     */
+
+  }, {
+    key: "on",
+
+
+    /**
+     * Subscribe to events on this `FilterHandle`.
+     *
+     * @param {string} eventType - Indicates the type of events to listen to.
+     *   Currently, only `"change"` is supported.
+     * @param {FilterHandle~listener} listener - The callback function that
+     *   will be invoked when the event occurs.
+     * @return {string} - A token to pass to {@link FilterHandle#off} to cancel
+     *   this subscription.
+     */
+    value: function on(eventType, listener) {
+      return this._emitter.on(eventType, listener);
+    }
+
+    /**
+     * Cancel event subscriptions created by {@link FilterHandle#on}.
+     *
+     * @param {string} eventType - The type of event to unsubscribe.
+     * @param {string|FilterHandle~listener} listener - Either the callback
+     *   function previously passed into {@link FilterHandle#on}, or the
+     *   string that was returned from {@link FilterHandle#on}.
+     */
+
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      return this._emitter.off(eventType, listener);
+    }
+  }, {
+    key: "_onChange",
+    value: function _onChange(extraInfo) {
+      if (!this._filterSet) return;
+      this._filterVar.set(this._filterSet.value, this._mergeExtraInfo(extraInfo));
+    }
+
+    /**
+     * @callback FilterHandle~listener
+     * @param {Object} event - An object containing details of the event. For
+     *   `"change"` events, this includes the properties `value` (the new
+     *   value of the filter set, or `null` if no filter set is active),
+     *   `oldValue` (the previous value of the filter set), and `sender` (the
+     *   `FilterHandle` instance that made the change).
+     */
+
+  }, {
+    key: "filteredKeys",
+    get: function get() {
+      return this._filterSet ? this._filterSet.value : null;
+    }
+  }]);
+
+  return FilterHandle;
+}();
+
+/**
+ * @event FilterHandle#change
+ * @type {object}
+ * @property {object} value - The new value of the filter set, or `null`
+ *   if no filter set is active.
+ * @property {object} oldValue - The previous value of the filter set.
+ * @property {FilterHandle} sender - The `FilterHandle` instance that
+ *   changed the value.
+ */
+
+},{"./events":1,"./filterset":3,"./group":4,"./util":11}],3:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _util = require("./util");
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+function naturalComparator(a, b) {
+  if (a === b) {
+    return 0;
+  } else if (a < b) {
+    return -1;
+  } else if (a > b) {
+    return 1;
+  }
+}
+
+/**
+ * @private
+ */
+
+var FilterSet = function () {
+  function FilterSet() {
+    _classCallCheck(this, FilterSet);
+
+    this.reset();
+  }
+
+  _createClass(FilterSet, [{
+    key: "reset",
+    value: function reset() {
+      // Key: handle ID, Value: array of selected keys, or null
+      this._handles = {};
+      // Key: key string, Value: count of handles that include it
+      this._keys = {};
+      this._value = null;
+      this._activeHandles = 0;
+    }
+  }, {
+    key: "update",
+    value: function update(handleId, keys) {
+      if (keys !== null) {
+        keys = keys.slice(0); // clone before sorting
+        keys.sort(naturalComparator);
+      }
+
+      var _diffSortedLists = (0, _util.diffSortedLists)(this._handles[handleId], keys),
+          added = _diffSortedLists.added,
+          removed = _diffSortedLists.removed;
+
+      this._handles[handleId] = keys;
+
+      for (var i = 0; i < added.length; i++) {
+        this._keys[added[i]] = (this._keys[added[i]] || 0) + 1;
+      }
+      for (var _i = 0; _i < removed.length; _i++) {
+        this._keys[removed[_i]]--;
+      }
+
+      this._updateValue(keys);
+    }
+
+    /**
+     * @param {string[]} keys Sorted array of strings that indicate
+     * a superset of possible keys.
+     * @private
+     */
+
+  }, {
+    key: "_updateValue",
+    value: function _updateValue() {
+      var keys = arguments.length > 0 && arguments[0] !== undefined ? arguments[0] : this._allKeys;
+
+      var handleCount = Object.keys(this._handles).length;
+      if (handleCount === 0) {
+        this._value = null;
+      } else {
+        this._value = [];
+        for (var i = 0; i < keys.length; i++) {
+          var count = this._keys[keys[i]];
+          if (count === handleCount) {
+            this._value.push(keys[i]);
+          }
+        }
+      }
+    }
+  }, {
+    key: "clear",
+    value: function clear(handleId) {
+      if (typeof this._handles[handleId] === "undefined") {
+        return;
+      }
+
+      var keys = this._handles[handleId];
+      if (!keys) {
+        keys = [];
+      }
+
+      for (var i = 0; i < keys.length; i++) {
+        this._keys[keys[i]]--;
+      }
+      delete this._handles[handleId];
+
+      this._updateValue();
+    }
+  }, {
+    key: "value",
+    get: function get() {
+      return this._value;
+    }
+  }, {
+    key: "_allKeys",
+    get: function get() {
+      var allKeys = Object.keys(this._keys);
+      allKeys.sort(naturalComparator);
+      return allKeys;
+    }
+  }]);
+
+  return FilterSet;
+}();
+
+exports.default = FilterSet;
+
+},{"./util":11}],4:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _typeof = typeof Symbol === "function" && typeof Symbol.iterator === "symbol" ? function (obj) { return typeof obj; } : function (obj) { return obj && typeof Symbol === "function" && obj.constructor === Symbol && obj !== Symbol.prototype ? "symbol" : typeof obj; };
+
+exports.default = group;
+
+var _var2 = require("./var");
+
+var _var3 = _interopRequireDefault(_var2);
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+// Use a global so that multiple copies of crosstalk.js can be loaded and still
+// have groups behave as singletons across all copies.
+global.__crosstalk_groups = global.__crosstalk_groups || {};
+var groups = global.__crosstalk_groups;
+
+function group(groupName) {
+  if (groupName && typeof groupName === "string") {
+    if (!groups.hasOwnProperty(groupName)) {
+      groups[groupName] = new Group(groupName);
+    }
+    return groups[groupName];
+  } else if ((typeof groupName === "undefined" ? "undefined" : _typeof(groupName)) === "object" && groupName._vars && groupName.var) {
+    // Appears to already be a group object
+    return groupName;
+  } else if (Array.isArray(groupName) && groupName.length == 1 && typeof groupName[0] === "string") {
+    return group(groupName[0]);
+  } else {
+    throw new Error("Invalid groupName argument");
+  }
+}
+
+var Group = function () {
+  function Group(name) {
+    _classCallCheck(this, Group);
+
+    this.name = name;
+    this._vars = {};
+  }
+
+  _createClass(Group, [{
+    key: "var",
+    value: function _var(name) {
+      if (!name || typeof name !== "string") {
+        throw new Error("Invalid var name");
+      }
+
+      if (!this._vars.hasOwnProperty(name)) this._vars[name] = new _var3.default(this, name);
+      return this._vars[name];
+    }
+  }, {
+    key: "has",
+    value: function has(name) {
+      if (!name || typeof name !== "string") {
+        throw new Error("Invalid var name");
+      }
+
+      return this._vars.hasOwnProperty(name);
+    }
+  }]);
+
+  return Group;
+}();
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./var":12}],5:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _group = require("./group");
+
+var _group2 = _interopRequireDefault(_group);
+
+var _selection = require("./selection");
+
+var _filter = require("./filter");
+
+var _input = require("./input");
+
+require("./input_selectize");
+
+require("./input_checkboxgroup");
+
+require("./input_slider");
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+var defaultGroup = (0, _group2.default)("default");
+
+function var_(name) {
+  return defaultGroup.var(name);
+}
+
+function has(name) {
+  return defaultGroup.has(name);
+}
+
+if (global.Shiny) {
+  global.Shiny.addCustomMessageHandler("update-client-value", function (message) {
+    if (typeof message.group === "string") {
+      (0, _group2.default)(message.group).var(message.name).set(message.value);
+    } else {
+      var_(message.name).set(message.value);
+    }
+  });
+}
+
+var crosstalk = {
+  group: _group2.default,
+  var: var_,
+  has: has,
+  SelectionHandle: _selection.SelectionHandle,
+  FilterHandle: _filter.FilterHandle,
+  bind: _input.bind
+};
+
+/**
+ * @namespace crosstalk
+ */
+exports.default = crosstalk;
+
+global.crosstalk = crosstalk;
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./group":4,"./input":6,"./input_checkboxgroup":7,"./input_selectize":8,"./input_slider":9,"./selection":10}],6:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+exports.register = register;
+exports.bind = bind;
+var $ = global.jQuery;
+
+var bindings = {};
+
+function register(reg) {
+  bindings[reg.className] = reg;
+  if (global.document && global.document.readyState !== "complete") {
+    $(function () {
+      bind();
+    });
+  } else if (global.document) {
+    setTimeout(bind, 100);
+  }
+}
+
+function bind() {
+  Object.keys(bindings).forEach(function (className) {
+    var binding = bindings[className];
+    $("." + binding.className).not(".crosstalk-input-bound").each(function (i, el) {
+      bindInstance(binding, el);
+    });
+  });
+}
+
+// Escape jQuery identifier
+function $escape(val) {
+  return val.replace(/([!"#$%&'()*+,./:;<=>?@[\\\]^`{|}~])/g, "\\$1");
+}
+
+function bindEl(el) {
+  var $el = $(el);
+  Object.keys(bindings).forEach(function (className) {
+    if ($el.hasClass(className) && !$el.hasClass("crosstalk-input-bound")) {
+      var binding = bindings[className];
+      bindInstance(binding, el);
+    }
+  });
+}
+
+function bindInstance(binding, el) {
+  var jsonEl = $(el).find("script[type='application/json'][data-for='" + $escape(el.id) + "']");
+  var data = JSON.parse(jsonEl[0].innerText);
+
+  var instance = binding.factory(el, data);
+  $(el).data("crosstalk-instance", instance);
+  $(el).addClass("crosstalk-input-bound");
+}
+
+if (global.Shiny) {
+  var inputBinding = new global.Shiny.InputBinding();
+  var _$ = global.jQuery;
+  _$.extend(inputBinding, {
+    find: function find(scope) {
+      return _$(scope).find(".crosstalk-input");
+    },
+    initialize: function initialize(el) {
+      if (!_$(el).hasClass("crosstalk-input-bound")) {
+        bindEl(el);
+      }
+    },
+    getId: function getId(el) {
+      return el.id;
+    },
+    getValue: function getValue(el) {},
+    setValue: function setValue(el, value) {},
+    receiveMessage: function receiveMessage(el, data) {},
+    subscribe: function subscribe(el, callback) {
+      _$(el).data("crosstalk-instance").resume();
+    },
+    unsubscribe: function unsubscribe(el) {
+      _$(el).data("crosstalk-instance").suspend();
+    }
+  });
+  global.Shiny.inputBindings.register(inputBinding, "crosstalk.inputBinding");
+}
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{}],7:[function(require,module,exports){
+(function (global){
+"use strict";
+
+var _input = require("./input");
+
+var input = _interopRequireWildcard(_input);
+
+var _filter = require("./filter");
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+var $ = global.jQuery;
+
+input.register({
+  className: "crosstalk-input-checkboxgroup",
+
+  factory: function factory(el, data) {
+    /*
+     * map: {"groupA": ["keyA", "keyB", ...], ...}
+     * group: "ct-groupname"
+     */
+    var ctHandle = new _filter.FilterHandle(data.group);
+
+    var lastKnownKeys = void 0;
+    var $el = $(el);
+    $el.on("change", "input[type='checkbox']", function () {
+      var checked = $el.find("input[type='checkbox']:checked");
+      if (checked.length === 0) {
+        lastKnownKeys = null;
+        ctHandle.clear();
+      } else {
+        var keys = {};
+        checked.each(function () {
+          data.map[this.value].forEach(function (key) {
+            keys[key] = true;
+          });
+        });
+        var keyArray = Object.keys(keys);
+        keyArray.sort();
+        lastKnownKeys = keyArray;
+        ctHandle.set(keyArray);
+      }
+    });
+
+    return {
+      suspend: function suspend() {
+        ctHandle.clear();
+      },
+      resume: function resume() {
+        if (lastKnownKeys) ctHandle.set(lastKnownKeys);
+      }
+    };
+  }
+});
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./input":6}],8:[function(require,module,exports){
+(function (global){
+"use strict";
+
+var _input = require("./input");
+
+var input = _interopRequireWildcard(_input);
+
+var _util = require("./util");
+
+var util = _interopRequireWildcard(_util);
+
+var _filter = require("./filter");
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+var $ = global.jQuery;
+
+input.register({
+  className: "crosstalk-input-select",
+
+  factory: function factory(el, data) {
+    /*
+     * items: {value: [...], label: [...]}
+     * map: {"groupA": ["keyA", "keyB", ...], ...}
+     * group: "ct-groupname"
+     */
+
+    var first = [{ value: "", label: "(All)" }];
+    var items = util.dataframeToD3(data.items);
+    var opts = {
+      options: first.concat(items),
+      valueField: "value",
+      labelField: "label",
+      searchField: "label"
+    };
+
+    var select = $(el).find("select")[0];
+
+    var selectize = $(select).selectize(opts)[0].selectize;
+
+    var ctHandle = new _filter.FilterHandle(data.group);
+
+    var lastKnownKeys = void 0;
+    selectize.on("change", function () {
+      if (selectize.items.length === 0) {
+        lastKnownKeys = null;
+        ctHandle.clear();
+      } else {
+        var keys = {};
+        selectize.items.forEach(function (group) {
+          data.map[group].forEach(function (key) {
+            keys[key] = true;
+          });
+        });
+        var keyArray = Object.keys(keys);
+        keyArray.sort();
+        lastKnownKeys = keyArray;
+        ctHandle.set(keyArray);
+      }
+    });
+
+    return {
+      suspend: function suspend() {
+        ctHandle.clear();
+      },
+      resume: function resume() {
+        if (lastKnownKeys) ctHandle.set(lastKnownKeys);
+      }
+    };
+  }
+});
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./input":6,"./util":11}],9:[function(require,module,exports){
+(function (global){
+"use strict";
+
+var _slicedToArray = function () { function sliceIterator(arr, i) { var _arr = []; var _n = true; var _d = false; var _e = undefined; try { for (var _i = arr[Symbol.iterator](), _s; !(_n = (_s = _i.next()).done); _n = true) { _arr.push(_s.value); if (i && _arr.length === i) break; } } catch (err) { _d = true; _e = err; } finally { try { if (!_n && _i["return"]) _i["return"](); } finally { if (_d) throw _e; } } return _arr; } return function (arr, i) { if (Array.isArray(arr)) { return arr; } else if (Symbol.iterator in Object(arr)) { return sliceIterator(arr, i); } else { throw new TypeError("Invalid attempt to destructure non-iterable instance"); } }; }();
+
+var _input = require("./input");
+
+var input = _interopRequireWildcard(_input);
+
+var _filter = require("./filter");
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+var $ = global.jQuery;
+var strftime = global.strftime;
+
+input.register({
+  className: "crosstalk-input-slider",
+
+  factory: function factory(el, data) {
+    /*
+     * map: {"groupA": ["keyA", "keyB", ...], ...}
+     * group: "ct-groupname"
+     */
+    var ctHandle = new _filter.FilterHandle(data.group);
+
+    var opts = {};
+    var $el = $(el).find("input");
+    var dataType = $el.data("data-type");
+    var timeFormat = $el.data("time-format");
+    var round = $el.data("round");
+    var timeFormatter = void 0;
+
+    // Set up formatting functions
+    if (dataType === "date") {
+      timeFormatter = strftime.utc();
+      opts.prettify = function (num) {
+        return timeFormatter(timeFormat, new Date(num));
+      };
+    } else if (dataType === "datetime") {
+      var timezone = $el.data("timezone");
+      if (timezone) timeFormatter = strftime.timezone(timezone);else timeFormatter = strftime;
+
+      opts.prettify = function (num) {
+        return timeFormatter(timeFormat, new Date(num));
+      };
+    } else if (dataType === "number") {
+      if (typeof round !== "undefined") opts.prettify = function (num) {
+        var factor = Math.pow(10, round);
+        return Math.round(num * factor) / factor;
+      };
+    }
+
+    $el.ionRangeSlider(opts);
+
+    function getValue() {
+      var result = $el.data("ionRangeSlider").result;
+
+      // Function for converting numeric value from slider to appropriate type.
+      var convert = void 0;
+      var dataType = $el.data("data-type");
+      if (dataType === "date") {
+        convert = function convert(val) {
+          return formatDateUTC(new Date(+val));
+        };
+      } else if (dataType === "datetime") {
+        convert = function convert(val) {
+          // Convert ms to s
+          return +val / 1000;
+        };
+      } else {
+        convert = function convert(val) {
+          return +val;
+        };
+      }
+
+      if ($el.data("ionRangeSlider").options.type === "double") {
+        return [convert(result.from), convert(result.to)];
+      } else {
+        return convert(result.from);
+      }
+    }
+
+    var lastKnownKeys = null;
+
+    $el.on("change.crosstalkSliderInput", function (event) {
+      if (!$el.data("updating") && !$el.data("animating")) {
+        var _getValue = getValue(),
+            _getValue2 = _slicedToArray(_getValue, 2),
+            from = _getValue2[0],
+            to = _getValue2[1];
+
+        var keys = [];
+        for (var i = 0; i < data.values.length; i++) {
+          var val = data.values[i];
+          if (val >= from && val <= to) {
+            keys.push(data.keys[i]);
+          }
+        }
+        keys.sort();
+        ctHandle.set(keys);
+        lastKnownKeys = keys;
+      }
+    });
+
+    // let $el = $(el);
+    // $el.on("change", "input[type="checkbox"]", function() {
+    //   let checked = $el.find("input[type="checkbox"]:checked");
+    //   if (checked.length === 0) {
+    //     ctHandle.clear();
+    //   } else {
+    //     let keys = {};
+    //     checked.each(function() {
+    //       data.map[this.value].forEach(function(key) {
+    //         keys[key] = true;
+    //       });
+    //     });
+    //     let keyArray = Object.keys(keys);
+    //     keyArray.sort();
+    //     ctHandle.set(keyArray);
+    //   }
+    // });
+
+    return {
+      suspend: function suspend() {
+        ctHandle.clear();
+      },
+      resume: function resume() {
+        if (lastKnownKeys) ctHandle.set(lastKnownKeys);
+      }
+    };
+  }
+});
+
+// Convert a number to a string with leading zeros
+function padZeros(n, digits) {
+  var str = n.toString();
+  while (str.length < digits) {
+    str = "0" + str;
+  }return str;
+}
+
+// Given a Date object, return a string in yyyy-mm-dd format, using the
+// UTC date. This may be a day off from the date in the local time zone.
+function formatDateUTC(date) {
+  if (date instanceof Date) {
+    return date.getUTCFullYear() + "-" + padZeros(date.getUTCMonth() + 1, 2) + "-" + padZeros(date.getUTCDate(), 2);
+  } else {
+    return null;
+  }
+}
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./filter":2,"./input":6}],10:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+exports.SelectionHandle = undefined;
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _events = require("./events");
+
+var _events2 = _interopRequireDefault(_events);
+
+var _group = require("./group");
+
+var _group2 = _interopRequireDefault(_group);
+
+var _util = require("./util");
+
+var util = _interopRequireWildcard(_util);
+
+function _interopRequireWildcard(obj) { if (obj && obj.__esModule) { return obj; } else { var newObj = {}; if (obj != null) { for (var key in obj) { if (Object.prototype.hasOwnProperty.call(obj, key)) newObj[key] = obj[key]; } } newObj.default = obj; return newObj; } }
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+/**
+ * Use this class to read and write (and listen for changes to) the selection
+ * for a Crosstalk group. This is intended to be used for linked brushing.
+ *
+ * If two (or more) `SelectionHandle` instances in the same webpage share the
+ * same group name, they will share the same state. Setting the selection using
+ * one `SelectionHandle` instance will result in the `value` property instantly
+ * changing across the others, and `"change"` event listeners on all instances
+ * (including the one that initiated the sending) will fire.
+ *
+ * @param {string} [group] - The name of the Crosstalk group, or if none,
+ *   null or undefined (or any other falsy value). This can be changed later
+ *   via the [SelectionHandle#setGroup](#setGroup) method.
+ * @param {Object} [extraInfo] - An object whose properties will be copied to
+ *   the event object whenever an event is emitted.
+ */
+var SelectionHandle = exports.SelectionHandle = function () {
+  function SelectionHandle() {
+    var group = arguments.length > 0 && arguments[0] !== undefined ? arguments[0] : null;
+    var extraInfo = arguments.length > 1 && arguments[1] !== undefined ? arguments[1] : null;
+
+    _classCallCheck(this, SelectionHandle);
+
+    this._eventRelay = new _events2.default();
+    this._emitter = new util.SubscriptionTracker(this._eventRelay);
+
+    // Name of the group we're currently tracking, if any. Can change over time.
+    this._group = null;
+    // The Var we're currently tracking, if any. Can change over time.
+    this._var = null;
+    // The event handler subscription we currently have on var.on("change").
+    this._varOnChangeSub = null;
+
+    this._extraInfo = util.extend({ sender: this }, extraInfo);
+
+    this.setGroup(group);
+  }
+
+  /**
+   * Changes the Crosstalk group membership of this SelectionHandle. The group
+   * being switched away from (if any) will not have its selection value
+   * modified as a result of calling `setGroup`, even if this handle was the
+   * most recent handle to set the selection of the group.
+   *
+   * The group being switched to (if any) will also not have its selection value
+   * modified as a result of calling `setGroup`. If you want to set the
+   * selection value of the new group, call `set` explicitly.
+   *
+   * @param {string} group - The name of the Crosstalk group, or null (or
+   *   undefined) to clear the group.
+   */
+
+
+  _createClass(SelectionHandle, [{
+    key: "setGroup",
+    value: function setGroup(group) {
+      var _this = this;
+
+      // If group is unchanged, do nothing
+      if (this._group === group) return;
+      // Treat null, undefined, and other falsy values the same
+      if (!this._group && !group) return;
+
+      if (this._var) {
+        this._var.off("change", this._varOnChangeSub);
+        this._var = null;
+        this._varOnChangeSub = null;
+      }
+
+      this._group = group;
+
+      if (group) {
+        this._var = (0, _group2.default)(group).var("selection");
+        var sub = this._var.on("change", function (e) {
+          _this._eventRelay.trigger("change", e, _this);
+        });
+        this._varOnChangeSub = sub;
+      }
+    }
+
+    /**
+     * Retrieves the current selection for the group represented by this
+     * `SelectionHandle`.
+     *
+     * - If no selection is active, then this value will be falsy.
+     * - If a selection is active, but no data points are selected, then this
+     *   value will be an empty array.
+     * - If a selection is active, and data points are selected, then the keys
+     *   of the selected data points will be present in the array.
+     */
+
+  }, {
+    key: "_mergeExtraInfo",
+
+
+    /**
+     * Combines the given `extraInfo` (if any) with the handle's default
+     * `_extraInfo` (if any).
+     * @private
+     */
+    value: function _mergeExtraInfo(extraInfo) {
+      // Important incidental effect: shallow clone is returned
+      return util.extend({}, this._extraInfo ? this._extraInfo : null, extraInfo ? extraInfo : null);
+    }
+
+    /**
+     * Overwrites the current selection for the group, and raises the `"change"`
+     * event among all of the group's '`SelectionHandle` instances (including
+     * this one).
+     *
+     * @fires SelectionHandle#change
+     * @param {string[]} selectedKeys - Falsy, empty array, or array of keys (see
+     *   {@link SelectionHandle#value}).
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any options that were
+     *   passed into the `SelectionHandle` constructor).
+     */
+
+  }, {
+    key: "set",
+    value: function set(selectedKeys, extraInfo) {
+      if (this._var) this._var.set(selectedKeys, this._mergeExtraInfo(extraInfo));
+    }
+
+    /**
+     * Overwrites the current selection for the group, and raises the `"change"`
+     * event among all of the group's '`SelectionHandle` instances (including
+     * this one).
+     *
+     * @fires SelectionHandle#change
+     * @param {Object} [extraInfo] - Extra properties to be included on the event
+     *   object that's passed to listeners (in addition to any that were passed
+     *   into the `SelectionHandle` constructor).
+     */
+
+  }, {
+    key: "clear",
+    value: function clear(extraInfo) {
+      if (this._var) this.set(void 0, this._mergeExtraInfo(extraInfo));
+    }
+
+    /**
+     * Subscribes to events on this `SelectionHandle`.
+     *
+     * @param {string} eventType - Indicates the type of events to listen to.
+     *   Currently, only `"change"` is supported.
+     * @param {SelectionHandle~listener} listener - The callback function that
+     *   will be invoked when the event occurs.
+     * @return {string} - A token to pass to {@link SelectionHandle#off} to cancel
+     *   this subscription.
+     */
+
+  }, {
+    key: "on",
+    value: function on(eventType, listener) {
+      return this._emitter.on(eventType, listener);
+    }
+
+    /**
+     * Cancels event subscriptions created by {@link SelectionHandle#on}.
+     *
+     * @param {string} eventType - The type of event to unsubscribe.
+     * @param {string|SelectionHandle~listener} listener - Either the callback
+     *   function previously passed into {@link SelectionHandle#on}, or the
+     *   string that was returned from {@link SelectionHandle#on}.
+     */
+
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      return this._emitter.off(eventType, listener);
+    }
+
+    /**
+     * Shuts down the `SelectionHandle` object.
+     *
+     * Removes all event listeners that were added through this handle.
+     */
+
+  }, {
+    key: "close",
+    value: function close() {
+      this._emitter.removeAllListeners();
+      this.setGroup(null);
+    }
+  }, {
+    key: "value",
+    get: function get() {
+      return this._var ? this._var.get() : null;
+    }
+  }]);
+
+  return SelectionHandle;
+}();
+
+/**
+ * @callback SelectionHandle~listener
+ * @param {Object} event - An object containing details of the event. For
+ *   `"change"` events, this includes the properties `value` (the new
+ *   value of the selection, or `undefined` if no selection is active),
+ *   `oldValue` (the previous value of the selection), and `sender` (the
+ *   `SelectionHandle` instance that made the change).
+ */
+
+/**
+ * @event SelectionHandle#change
+ * @type {object}
+ * @property {object} value - The new value of the selection, or `undefined`
+ *   if no selection is active.
+ * @property {object} oldValue - The previous value of the selection.
+ * @property {SelectionHandle} sender - The `SelectionHandle` instance that
+ *   changed the value.
+ */
+
+},{"./events":1,"./group":4,"./util":11}],11:[function(require,module,exports){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _typeof = typeof Symbol === "function" && typeof Symbol.iterator === "symbol" ? function (obj) { return typeof obj; } : function (obj) { return obj && typeof Symbol === "function" && obj.constructor === Symbol && obj !== Symbol.prototype ? "symbol" : typeof obj; };
+
+exports.extend = extend;
+exports.checkSorted = checkSorted;
+exports.diffSortedLists = diffSortedLists;
+exports.dataframeToD3 = dataframeToD3;
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+function extend(target) {
+  for (var _len = arguments.length, sources = Array(_len > 1 ? _len - 1 : 0), _key = 1; _key < _len; _key++) {
+    sources[_key - 1] = arguments[_key];
+  }
+
+  for (var i = 0; i < sources.length; i++) {
+    var src = sources[i];
+    if (typeof src === "undefined" || src === null) continue;
+
+    for (var key in src) {
+      if (src.hasOwnProperty(key)) {
+        target[key] = src[key];
+      }
+    }
+  }
+  return target;
+}
+
+function checkSorted(list) {
+  for (var i = 1; i < list.length; i++) {
+    if (list[i] <= list[i - 1]) {
+      throw new Error("List is not sorted or contains duplicate");
+    }
+  }
+}
+
+function diffSortedLists(a, b) {
+  var i_a = 0;
+  var i_b = 0;
+
+  if (!a) a = [];
+  if (!b) b = [];
+
+  var a_only = [];
+  var b_only = [];
+
+  checkSorted(a);
+  checkSorted(b);
+
+  while (i_a < a.length && i_b < b.length) {
+    if (a[i_a] === b[i_b]) {
+      i_a++;
+      i_b++;
+    } else if (a[i_a] < b[i_b]) {
+      a_only.push(a[i_a++]);
+    } else {
+      b_only.push(b[i_b++]);
+    }
+  }
+
+  if (i_a < a.length) a_only = a_only.concat(a.slice(i_a));
+  if (i_b < b.length) b_only = b_only.concat(b.slice(i_b));
+  return {
+    removed: a_only,
+    added: b_only
+  };
+}
+
+// Convert from wide: { colA: [1,2,3], colB: [4,5,6], ... }
+// to long: [ {colA: 1, colB: 4}, {colA: 2, colB: 5}, ... ]
+function dataframeToD3(df) {
+  var names = [];
+  var length = void 0;
+  for (var name in df) {
+    if (df.hasOwnProperty(name)) names.push(name);
+    if (_typeof(df[name]) !== "object" || typeof df[name].length === "undefined") {
+      throw new Error("All fields must be arrays");
+    } else if (typeof length !== "undefined" && length !== df[name].length) {
+      throw new Error("All fields must be arrays of the same length");
+    }
+    length = df[name].length;
+  }
+  var results = [];
+  var item = void 0;
+  for (var row = 0; row < length; row++) {
+    item = {};
+    for (var col = 0; col < names.length; col++) {
+      item[names[col]] = df[names[col]][row];
+    }
+    results.push(item);
+  }
+  return results;
+}
+
+/**
+ * Keeps track of all event listener additions/removals and lets all active
+ * listeners be removed with a single operation.
+ *
+ * @private
+ */
+
+var SubscriptionTracker = exports.SubscriptionTracker = function () {
+  function SubscriptionTracker(emitter) {
+    _classCallCheck(this, SubscriptionTracker);
+
+    this._emitter = emitter;
+    this._subs = {};
+  }
+
+  _createClass(SubscriptionTracker, [{
+    key: "on",
+    value: function on(eventType, listener) {
+      var sub = this._emitter.on(eventType, listener);
+      this._subs[sub] = eventType;
+      return sub;
+    }
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      var sub = this._emitter.off(eventType, listener);
+      if (sub) {
+        delete this._subs[sub];
+      }
+      return sub;
+    }
+  }, {
+    key: "removeAllListeners",
+    value: function removeAllListeners() {
+      var _this = this;
+
+      var current_subs = this._subs;
+      this._subs = {};
+      Object.keys(current_subs).forEach(function (sub) {
+        _this._emitter.off(current_subs[sub], sub);
+      });
+    }
+  }]);
+
+  return SubscriptionTracker;
+}();
+
+},{}],12:[function(require,module,exports){
+(function (global){
+"use strict";
+
+Object.defineProperty(exports, "__esModule", {
+  value: true
+});
+
+var _typeof = typeof Symbol === "function" && typeof Symbol.iterator === "symbol" ? function (obj) { return typeof obj; } : function (obj) { return obj && typeof Symbol === "function" && obj.constructor === Symbol && obj !== Symbol.prototype ? "symbol" : typeof obj; };
+
+var _createClass = function () { function defineProperties(target, props) { for (var i = 0; i < props.length; i++) { var descriptor = props[i]; descriptor.enumerable = descriptor.enumerable || false; descriptor.configurable = true; if ("value" in descriptor) descriptor.writable = true; Object.defineProperty(target, descriptor.key, descriptor); } } return function (Constructor, protoProps, staticProps) { if (protoProps) defineProperties(Constructor.prototype, protoProps); if (staticProps) defineProperties(Constructor, staticProps); return Constructor; }; }();
+
+var _events = require("./events");
+
+var _events2 = _interopRequireDefault(_events);
+
+function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+
+function _classCallCheck(instance, Constructor) { if (!(instance instanceof Constructor)) { throw new TypeError("Cannot call a class as a function"); } }
+
+var Var = function () {
+  function Var(group, name, /*optional*/value) {
+    _classCallCheck(this, Var);
+
+    this._group = group;
+    this._name = name;
+    this._value = value;
+    this._events = new _events2.default();
+  }
+
+  _createClass(Var, [{
+    key: "get",
+    value: function get() {
+      return this._value;
+    }
+  }, {
+    key: "set",
+    value: function set(value, /*optional*/event) {
+      if (this._value === value) {
+        // Do nothing; the value hasn't changed
+        return;
+      }
+      var oldValue = this._value;
+      this._value = value;
+      // Alert JavaScript listeners that the value has changed
+      var evt = {};
+      if (event && (typeof event === "undefined" ? "undefined" : _typeof(event)) === "object") {
+        for (var k in event) {
+          if (event.hasOwnProperty(k)) evt[k] = event[k];
+        }
+      }
+      evt.oldValue = oldValue;
+      evt.value = value;
+      this._events.trigger("change", evt, this);
+
+      // TODO: Make this extensible, to let arbitrary back-ends know that
+      // something has changed
+      if (global.Shiny && global.Shiny.onInputChange) {
+        global.Shiny.onInputChange(".clientValue-" + (this._group.name !== null ? this._group.name + "-" : "") + this._name, typeof value === "undefined" ? null : value);
+      }
+    }
+  }, {
+    key: "on",
+    value: function on(eventType, listener) {
+      return this._events.on(eventType, listener);
+    }
+  }, {
+    key: "off",
+    value: function off(eventType, listener) {
+      return this._events.off(eventType, listener);
+    }
+  }]);
+
+  return Var;
+}();
+
+exports.default = Var;
+
+}).call(this,typeof global !== "undefined" ? global : typeof self !== "undefined" ? self : typeof window !== "undefined" ? window : {})
+
+},{"./events":1}]},{},[5])
+//# sourceMappingURL=crosstalk.js.map
diff --git a/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/js/crosstalk.js.map b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/js/crosstalk.js.map
new file mode 100644
index 0000000..cff94f0
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/js/crosstalk.js.map
@@ -0,0 +1,37 @@
+{
+  "version": 3,
+  "sources": [
+    "node_modules/browser-pack/_prelude.js",
+    "javascript/src/events.js",
+    "javascript/src/filter.js",
+    "javascript/src/filterset.js",
+    "javascript/src/group.js",
+    "javascript/src/index.js",
+    "javascript/src/input.js",
+    "javascript/src/input_checkboxgroup.js",
+    "javascript/src/input_selectize.js",
+    "javascript/src/input_slider.js",
+    "javascript/src/selection.js",
+    "javascript/src/util.js",
+    "javascript/src/var.js"
+  ],
+  "names": [],
+  "mappings": 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+  "file": "generated.js",
+  "sourceRoot": "",
+  "sourcesContent": [
+    "(function(){function e(t,n,r){function s(o,u){if(!n[o]){if(!t[o]){var a=typeof require==\"function\"&&require;if(!u&&a)return a(o,!0);if(i)return i(o,!0);var f=new Error(\"Cannot find module '\"+o+\"'\");throw f.code=\"MODULE_NOT_FOUND\",f}var l=n[o]={exports:{}};t[o][0].call(l.exports,function(e){var n=t[o][1][e];return s(n?n:e)},l,l.exports,e,t,n,r)}return n[o].exports}var i=typeof require==\"function\"&&require;for(var o=0;o<r.length;o++)s(r[o]);return s}return e})()",
+    "export default class Events {\n  constructor() {\n    this._types = {};\n    this._seq = 0;\n  }\n\n  on(eventType, listener) {\n    let subs = this._types[eventType];\n    if (!subs) {\n      subs = this._types[eventType] = {};\n    }\n    let sub = \"sub\" + (this._seq++);\n    subs[sub] = listener;\n    return sub;\n  }\n\n  // Returns false if no match, or string for sub name if matched\n  off(eventType, listener) {\n    let subs = this._types[eventType];\n    if (typeof(listener) === \"function\") {\n      for (let key in subs) {\n        if (subs.hasOwnProperty(key)) {\n          if (subs[key] === listener) {\n            delete subs[key];\n            return key;\n          }\n        }\n      }\n      return false;\n    } else if (typeof(listener) === \"string\") {\n      if (subs && subs[listener]) {\n        delete subs[listener];\n        return listener;\n      }\n      return false;\n    } else {\n      throw new Error(\"Unexpected type for listener\");\n    }\n  }\n\n  trigger(eventType, arg, thisObj) {\n    let subs = this._types[eventType];\n    for (let key in subs) {\n      if (subs.hasOwnProperty(key)) {\n        subs[key].call(thisObj, arg);\n      }\n    }\n  }\n}\n",
+    "import Events from \"./events\";\nimport FilterSet from \"./filterset\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\nfunction getFilterSet(group) {\n  let fsVar = group.var(\"filterset\");\n  let result = fsVar.get();\n  if (!result) {\n    result = new FilterSet();\n    fsVar.set(result);\n  }\n  return result;\n}\n\nlet id = 1;\nfunction nextId() {\n  return id++;\n}\n\n/**\n * Use this class to contribute to, and listen for changes to, the filter set\n * for the given group of widgets. Filter input controls should create one\n * `FilterHandle` and only call {@link FilterHandle#set}. Output widgets that\n * wish to displayed filtered data should create one `FilterHandle` and use\n * the {@link FilterHandle#filteredKeys} property and listen for change\n * events.\n *\n * If two (or more) `FilterHandle` instances in the same webpage share the\n * same group name, they will contribute to a single \"filter set\". Each\n * `FilterHandle` starts out with a `null` value, which means they take\n * nothing away from the set of data that should be shown. To make a\n * `FilterHandle` actually remove data from the filter set, set its value to\n * an array of keys which should be displayed. Crosstalk will aggregate the\n * various key arrays by finding their intersection; only keys that are\n * present in all non-null filter handles are considered part of the filter\n * set.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the {@link FilterHandle#setGroup} method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class FilterHandle {\n  constructor(group, extraInfo) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The filterSet that we're tracking, if any. Can change over time.\n    this._filterSet = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._filterVar = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this._id = \"filter\" + nextId();\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this FilterHandle. If `set()` was\n   * previously called on this handle, switching groups will clear those keys\n   * from the old group's filter set. These keys will not be applied to the new\n   * group's filter set either. In other words, `setGroup()` effectively calls\n   * `clear()` before switching groups.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._filterVar) {\n      this._filterVar.off(\"change\", this._varOnChangeSub);\n      this.clear();\n      this._varOnChangeSub = null;\n      this._filterVar = null;\n      this._filterSet = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      group = grp(group);\n      this._filterSet = getFilterSet(group);\n      this._filterVar = grp(group).var(\"filter\");\n      let sub = this._filterVar.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Combine the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Close the handle. This clears this handle's contribution to the filter set,\n   * and unsubscribes all event listeners.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.clear();\n    this.setGroup(null);\n  }\n\n  /**\n   * Clear this handle's contribution to the filter set.\n   *\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  clear(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.clear(this._id);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * Set this handle's contribution to the filter set. This array should consist\n   * of the keys of the rows that _should_ be displayed; any keys that are not\n   * present in the array will be considered _filtered out_. Note that multiple\n   * `FilterHandle` instances in the group may each contribute an array of keys,\n   * and only those keys that appear in _all_ of the arrays make it through the\n   * filter.\n   *\n   * @param {string[]} keys - Empty array, or array of keys. To clear the\n   *   filter, don't pass an empty array; instead, use the\n   *   {@link FilterHandle#clear} method.\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  set(keys, extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.update(this._id, keys);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * @return {string[]|null} - Either: 1) an array of keys that made it through\n   *   all of the `FilterHandle` instances, or, 2) `null`, which means no filter\n   *   is being applied (all data should be displayed).\n   */\n  get filteredKeys() {\n    return this._filterSet ? this._filterSet.value : null;\n  }\n\n  /**\n   * Subscribe to events on this `FilterHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {FilterHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link FilterHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancel event subscriptions created by {@link FilterHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|FilterHandle~listener} listener - Either the callback\n   *   function previously passed into {@link FilterHandle#on}, or the\n   *   string that was returned from {@link FilterHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  _onChange(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterVar.set(this._filterSet.value, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * @callback FilterHandle~listener\n   * @param {Object} event - An object containing details of the event. For\n   *   `\"change\"` events, this includes the properties `value` (the new\n   *   value of the filter set, or `null` if no filter set is active),\n   *   `oldValue` (the previous value of the filter set), and `sender` (the\n   *   `FilterHandle` instance that made the change).\n   */\n\n}\n\n/**\n * @event FilterHandle#change\n * @type {object}\n * @property {object} value - The new value of the filter set, or `null`\n *   if no filter set is active.\n * @property {object} oldValue - The previous value of the filter set.\n * @property {FilterHandle} sender - The `FilterHandle` instance that\n *   changed the value.\n */\n",
+    "import { diffSortedLists } from \"./util\";\n\nfunction naturalComparator(a, b) {\n  if (a === b) {\n    return 0;\n  } else if (a < b) {\n    return -1;\n  } else if (a > b) {\n    return 1;\n  }\n}\n\n/**\n * @private\n */\nexport default class FilterSet {\n  constructor() {\n    this.reset();\n  }\n\n  reset() {\n    // Key: handle ID, Value: array of selected keys, or null\n    this._handles = {};\n    // Key: key string, Value: count of handles that include it\n    this._keys = {};\n    this._value = null;\n    this._activeHandles = 0;\n  }\n\n  get value() {\n    return this._value;\n  }\n\n  update(handleId, keys) {\n    if (keys !== null) {\n      keys = keys.slice(0); // clone before sorting\n      keys.sort(naturalComparator);\n    }\n\n    let {added, removed} = diffSortedLists(this._handles[handleId], keys);\n    this._handles[handleId] = keys;\n\n    for (let i = 0; i < added.length; i++) {\n      this._keys[added[i]] = (this._keys[added[i]] || 0) + 1;\n    }\n    for (let i = 0; i < removed.length; i++) {\n      this._keys[removed[i]]--;\n    }\n\n    this._updateValue(keys);\n  }\n\n  /**\n   * @param {string[]} keys Sorted array of strings that indicate\n   * a superset of possible keys.\n   * @private\n   */\n  _updateValue(keys = this._allKeys) {\n    let handleCount = Object.keys(this._handles).length;\n    if (handleCount === 0) {\n      this._value = null;\n    } else {\n      this._value = [];\n      for (let i = 0; i < keys.length; i++) {\n        let count = this._keys[keys[i]];\n        if (count === handleCount) {\n          this._value.push(keys[i]);\n        }\n      }\n    }\n  }\n\n  clear(handleId) {\n    if (typeof(this._handles[handleId]) === \"undefined\") {\n      return;\n    }\n\n    let keys = this._handles[handleId];\n    if (!keys) {\n      keys = [];\n    }\n\n    for (let i = 0; i < keys.length; i++) {\n      this._keys[keys[i]]--;\n    }\n    delete this._handles[handleId];\n\n    this._updateValue();\n  }\n\n  get _allKeys() {\n    let allKeys = Object.keys(this._keys);\n    allKeys.sort(naturalComparator);\n    return allKeys;\n  }\n}\n",
+    "import Var from \"./var\";\n\n// Use a global so that multiple copies of crosstalk.js can be loaded and still\n// have groups behave as singletons across all copies.\nglobal.__crosstalk_groups = global.__crosstalk_groups || {};\nlet groups = global.__crosstalk_groups;\n\nexport default function group(groupName) {\n  if (groupName && typeof(groupName) === \"string\") {\n    if (!groups.hasOwnProperty(groupName)) {\n      groups[groupName] = new Group(groupName);\n    }\n    return groups[groupName];\n  } else if (typeof(groupName) === \"object\" && groupName._vars && groupName.var) {\n    // Appears to already be a group object\n    return groupName;\n  } else if (Array.isArray(groupName) &&\n      groupName.length == 1 &&\n      typeof(groupName[0]) === \"string\") {\n    return group(groupName[0]);\n  } else {\n    throw new Error(\"Invalid groupName argument\");\n  }\n}\n\nclass Group {\n  constructor(name) {\n    this.name = name;\n    this._vars = {};\n  }\n\n  var(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    if (!this._vars.hasOwnProperty(name))\n      this._vars[name] = new Var(this, name);\n    return this._vars[name];\n  }\n\n  has(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    return this._vars.hasOwnProperty(name);\n  }\n}\n",
+    "import group from \"./group\";\nimport { SelectionHandle } from \"./selection\";\nimport { FilterHandle } from \"./filter\";\nimport { bind } from \"./input\";\nimport \"./input_selectize\";\nimport \"./input_checkboxgroup\";\nimport \"./input_slider\";\n\nconst defaultGroup = group(\"default\");\n\nfunction var_(name) {\n  return defaultGroup.var(name);\n}\n\nfunction has(name) {\n  return defaultGroup.has(name);\n}\n\nif (global.Shiny) {\n  global.Shiny.addCustomMessageHandler(\"update-client-value\", function(message) {\n    if (typeof(message.group) === \"string\") {\n      group(message.group).var(message.name).set(message.value);\n    } else {\n      var_(message.name).set(message.value);\n    }\n  });\n}\n\nconst crosstalk = {\n  group: group,\n  var: var_,\n  has: has,\n  SelectionHandle: SelectionHandle,\n  FilterHandle: FilterHandle,\n  bind: bind\n};\n\n/**\n * @namespace crosstalk\n */\nexport default crosstalk;\nglobal.crosstalk = crosstalk;\n",
+    "let $ = global.jQuery;\n\nlet bindings = {};\n\nexport function register(reg) {\n  bindings[reg.className] = reg;\n  if (global.document && global.document.readyState !== \"complete\") {\n    $(() => {\n      bind();\n    });\n  } else if (global.document) {\n    setTimeout(bind, 100);\n  }\n}\n\nexport function bind() {\n  Object.keys(bindings).forEach(function(className) {\n    let binding = bindings[className];\n    $(\".\" + binding.className).not(\".crosstalk-input-bound\").each(function(i, el) {\n      bindInstance(binding, el);\n    });\n  });\n}\n\n// Escape jQuery identifier\nfunction $escape(val) {\n  return val.replace(/([!\"#$%&'()*+,./:;<=>?@[\\\\\\]^`{|}~])/g, \"\\\\$1\");\n}\n\nfunction bindEl(el) {\n  let $el = $(el);\n  Object.keys(bindings).forEach(function(className) {\n    if ($el.hasClass(className) && !$el.hasClass(\"crosstalk-input-bound\")) {\n      let binding = bindings[className];\n      bindInstance(binding, el);\n    }\n  });\n}\n\nfunction bindInstance(binding, el) {\n  let jsonEl = $(el).find(\"script[type='application/json'][data-for='\" + $escape(el.id) + \"']\");\n  let data = JSON.parse(jsonEl[0].innerText);\n\n  let instance = binding.factory(el, data);\n  $(el).data(\"crosstalk-instance\", instance);\n  $(el).addClass(\"crosstalk-input-bound\");\n}\n\nif (global.Shiny) {\n  let inputBinding = new global.Shiny.InputBinding();\n  let $ = global.jQuery;\n  $.extend(inputBinding, {\n    find: function(scope) {\n      return $(scope).find(\".crosstalk-input\");\n    },\n    initialize: function(el) {\n      if (!$(el).hasClass(\"crosstalk-input-bound\")) {\n        bindEl(el);\n      }\n    },\n    getId: function(el) {\n      return el.id;\n    },\n    getValue: function(el) {\n\n    },\n    setValue: function(el, value) {\n\n    },\n    receiveMessage: function(el, data) {\n\n    },\n    subscribe: function(el, callback) {\n      $(el).data(\"crosstalk-instance\").resume();\n    },\n    unsubscribe: function(el) {\n      $(el).data(\"crosstalk-instance\").suspend();\n    }\n  });\n  global.Shiny.inputBindings.register(inputBinding, \"crosstalk.inputBinding\");\n}\n",
+    "import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-checkboxgroup\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    let $el = $(el);\n    $el.on(\"change\", \"input[type='checkbox']\", function() {\n      let checked = $el.find(\"input[type='checkbox']:checked\");\n      if (checked.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        checked.each(function() {\n          data.map[this.value].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n",
+    "import * as input from \"./input\";\nimport * as util from \"./util\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-select\",\n\n  factory: function(el, data) {\n    /*\n     * items: {value: [...], label: [...]}\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n\n    let first = [{value: \"\", label: \"(All)\"}];\n    let items = util.dataframeToD3(data.items);\n    let opts = {\n      options: first.concat(items),\n      valueField: \"value\",\n      labelField: \"label\",\n      searchField: \"label\"\n    };\n\n    let select = $(el).find(\"select\")[0];\n\n    let selectize = $(select).selectize(opts)[0].selectize;\n\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    selectize.on(\"change\", function() {\n      if (selectize.items.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        selectize.items.forEach(function(group) {\n          data.map[group].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n",
+    "import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\nlet strftime = global.strftime;\n\ninput.register({\n  className: \"crosstalk-input-slider\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let opts = {};\n    let $el = $(el).find(\"input\");\n    let dataType = $el.data(\"data-type\");\n    let timeFormat = $el.data(\"time-format\");\n    let round = $el.data(\"round\");\n    let timeFormatter;\n\n    // Set up formatting functions\n    if (dataType === \"date\") {\n      timeFormatter = strftime.utc();\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n\n    } else if (dataType === \"datetime\") {\n      let timezone = $el.data(\"timezone\");\n      if (timezone)\n        timeFormatter = strftime.timezone(timezone);\n      else\n        timeFormatter = strftime;\n\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n    } else if (dataType === \"number\") {\n      if (typeof round !== \"undefined\")\n        opts.prettify = function(num) {\n          let factor = Math.pow(10, round);\n          return Math.round(num * factor) / factor;\n        };\n    }\n\n    $el.ionRangeSlider(opts);\n\n    function getValue() {\n      let result = $el.data(\"ionRangeSlider\").result;\n\n      // Function for converting numeric value from slider to appropriate type.\n      let convert;\n      let dataType = $el.data(\"data-type\");\n      if (dataType === \"date\") {\n        convert = function(val) {\n          return formatDateUTC(new Date(+val));\n        };\n      } else if (dataType === \"datetime\") {\n        convert = function(val) {\n          // Convert ms to s\n          return +val / 1000;\n        };\n      } else {\n        convert = function(val) { return +val; };\n      }\n\n      if ($el.data(\"ionRangeSlider\").options.type === \"double\") {\n        return [convert(result.from), convert(result.to)];\n      } else {\n        return convert(result.from);\n      }\n    }\n\n    let lastKnownKeys = null;\n\n    $el.on(\"change.crosstalkSliderInput\", function(event) {\n      if (!$el.data(\"updating\") && !$el.data(\"animating\")) {\n        let [from, to] = getValue();\n        let keys = [];\n        for (let i = 0; i < data.values.length; i++) {\n          let val = data.values[i];\n          if (val >= from && val <= to) {\n            keys.push(data.keys[i]);\n          }\n        }\n        keys.sort();\n        ctHandle.set(keys);\n        lastKnownKeys = keys;\n      }\n    });\n\n\n    // let $el = $(el);\n    // $el.on(\"change\", \"input[type=\"checkbox\"]\", function() {\n    //   let checked = $el.find(\"input[type=\"checkbox\"]:checked\");\n    //   if (checked.length === 0) {\n    //     ctHandle.clear();\n    //   } else {\n    //     let keys = {};\n    //     checked.each(function() {\n    //       data.map[this.value].forEach(function(key) {\n    //         keys[key] = true;\n    //       });\n    //     });\n    //     let keyArray = Object.keys(keys);\n    //     keyArray.sort();\n    //     ctHandle.set(keyArray);\n    //   }\n    // });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n\n\n// Convert a number to a string with leading zeros\nfunction padZeros(n, digits) {\n  let str = n.toString();\n  while (str.length < digits)\n    str = \"0\" + str;\n  return str;\n}\n\n// Given a Date object, return a string in yyyy-mm-dd format, using the\n// UTC date. This may be a day off from the date in the local time zone.\nfunction formatDateUTC(date) {\n  if (date instanceof Date) {\n    return date.getUTCFullYear() + \"-\" +\n           padZeros(date.getUTCMonth()+1, 2) + \"-\" +\n           padZeros(date.getUTCDate(), 2);\n\n  } else {\n    return null;\n  }\n}\n",
+    "import Events from \"./events\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\n/**\n * Use this class to read and write (and listen for changes to) the selection\n * for a Crosstalk group. This is intended to be used for linked brushing.\n *\n * If two (or more) `SelectionHandle` instances in the same webpage share the\n * same group name, they will share the same state. Setting the selection using\n * one `SelectionHandle` instance will result in the `value` property instantly\n * changing across the others, and `\"change\"` event listeners on all instances\n * (including the one that initiated the sending) will fire.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the [SelectionHandle#setGroup](#setGroup) method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class SelectionHandle {\n\n  constructor(group = null, extraInfo = null) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._var = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this SelectionHandle. The group\n   * being switched away from (if any) will not have its selection value\n   * modified as a result of calling `setGroup`, even if this handle was the\n   * most recent handle to set the selection of the group.\n   *\n   * The group being switched to (if any) will also not have its selection value\n   * modified as a result of calling `setGroup`. If you want to set the\n   * selection value of the new group, call `set` explicitly.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._var) {\n      this._var.off(\"change\", this._varOnChangeSub);\n      this._var = null;\n      this._varOnChangeSub = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      this._var = grp(group).var(\"selection\");\n      let sub = this._var.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Retrieves the current selection for the group represented by this\n   * `SelectionHandle`.\n   *\n   * - If no selection is active, then this value will be falsy.\n   * - If a selection is active, but no data points are selected, then this\n   *   value will be an empty array.\n   * - If a selection is active, and data points are selected, then the keys\n   *   of the selected data points will be present in the array.\n   */\n  get value() {\n    return this._var ? this._var.get() : null;\n  }\n\n  /**\n   * Combines the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    // Important incidental effect: shallow clone is returned\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {string[]} selectedKeys - Falsy, empty array, or array of keys (see\n   *   {@link SelectionHandle#value}).\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `SelectionHandle` constructor).\n   */\n  set(selectedKeys, extraInfo) {\n    if (this._var)\n      this._var.set(selectedKeys, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any that were passed\n   *   into the `SelectionHandle` constructor).\n   */\n  clear(extraInfo) {\n    if (this._var)\n      this.set(void 0, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Subscribes to events on this `SelectionHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {SelectionHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link SelectionHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancels event subscriptions created by {@link SelectionHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|SelectionHandle~listener} listener - Either the callback\n   *   function previously passed into {@link SelectionHandle#on}, or the\n   *   string that was returned from {@link SelectionHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  /**\n   * Shuts down the `SelectionHandle` object.\n   *\n   * Removes all event listeners that were added through this handle.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.setGroup(null);\n  }\n}\n\n/**\n * @callback SelectionHandle~listener\n * @param {Object} event - An object containing details of the event. For\n *   `\"change\"` events, this includes the properties `value` (the new\n *   value of the selection, or `undefined` if no selection is active),\n *   `oldValue` (the previous value of the selection), and `sender` (the\n *   `SelectionHandle` instance that made the change).\n */\n\n/**\n * @event SelectionHandle#change\n * @type {object}\n * @property {object} value - The new value of the selection, or `undefined`\n *   if no selection is active.\n * @property {object} oldValue - The previous value of the selection.\n * @property {SelectionHandle} sender - The `SelectionHandle` instance that\n *   changed the value.\n */\n",
+    "export function extend(target, ...sources) {\n  for (let i = 0; i < sources.length; i++) {\n    let src = sources[i];\n    if (typeof(src) === \"undefined\" || src === null)\n      continue;\n\n    for (let key in src) {\n      if (src.hasOwnProperty(key)) {\n        target[key] = src[key];\n      }\n    }\n  }\n  return target;\n}\n\nexport function checkSorted(list) {\n  for (let i = 1; i < list.length; i++) {\n    if (list[i] <= list[i-1]) {\n      throw new Error(\"List is not sorted or contains duplicate\");\n    }\n  }\n}\n\nexport function diffSortedLists(a, b) {\n  let i_a = 0;\n  let i_b = 0;\n\n  if (!a) a = [];\n  if (!b) b = [];\n\n  let a_only = [];\n  let b_only = [];\n\n  checkSorted(a);\n  checkSorted(b);\n\n  while (i_a < a.length && i_b < b.length) {\n    if (a[i_a] === b[i_b]) {\n      i_a++;\n      i_b++;\n    } else if (a[i_a] < b[i_b]) {\n      a_only.push(a[i_a++]);\n    } else {\n      b_only.push(b[i_b++]);\n    }\n  }\n\n  if (i_a < a.length)\n    a_only = a_only.concat(a.slice(i_a));\n  if (i_b < b.length)\n    b_only = b_only.concat(b.slice(i_b));\n  return {\n    removed: a_only,\n    added: b_only\n  };\n}\n\n// Convert from wide: { colA: [1,2,3], colB: [4,5,6], ... }\n// to long: [ {colA: 1, colB: 4}, {colA: 2, colB: 5}, ... ]\nexport function dataframeToD3(df) {\n  let names = [];\n  let length;\n  for (let name in df) {\n    if (df.hasOwnProperty(name))\n      names.push(name);\n    if (typeof(df[name]) !== \"object\" || typeof(df[name].length) === \"undefined\") {\n      throw new Error(\"All fields must be arrays\");\n    } else if (typeof(length) !== \"undefined\" && length !== df[name].length) {\n      throw new Error(\"All fields must be arrays of the same length\");\n    }\n    length = df[name].length;\n  }\n  let results = [];\n  let item;\n  for (let row = 0; row < length; row++) {\n    item = {};\n    for (let col = 0; col < names.length; col++) {\n      item[names[col]] = df[names[col]][row];\n    }\n    results.push(item);\n  }\n  return results;\n}\n\n/**\n * Keeps track of all event listener additions/removals and lets all active\n * listeners be removed with a single operation.\n *\n * @private\n */\nexport class SubscriptionTracker {\n  constructor(emitter) {\n    this._emitter = emitter;\n    this._subs = {};\n  }\n\n  on(eventType, listener) {\n    let sub = this._emitter.on(eventType, listener);\n    this._subs[sub] = eventType;\n    return sub;\n  }\n\n  off(eventType, listener) {\n    let sub = this._emitter.off(eventType, listener);\n    if (sub) {\n      delete this._subs[sub];\n    }\n    return sub;\n  }\n\n  removeAllListeners() {\n    let current_subs = this._subs;\n    this._subs = {};\n    Object.keys(current_subs).forEach((sub) => {\n      this._emitter.off(current_subs[sub], sub);\n    });\n  }\n}\n",
+    "import Events from \"./events\";\n\nexport default class Var {\n  constructor(group, name, /*optional*/ value) {\n    this._group = group;\n    this._name = name;\n    this._value = value;\n    this._events = new Events();\n  }\n\n  get() {\n    return this._value;\n  }\n\n  set(value, /*optional*/ event) {\n    if (this._value === value) {\n      // Do nothing; the value hasn't changed\n      return;\n    }\n    let oldValue = this._value;\n    this._value = value;\n    // Alert JavaScript listeners that the value has changed\n    let evt = {};\n    if (event && typeof(event) === \"object\") {\n      for (let k in event) {\n        if (event.hasOwnProperty(k))\n          evt[k] = event[k];\n      }\n    }\n    evt.oldValue = oldValue;\n    evt.value = value;\n    this._events.trigger(\"change\", evt, this);\n\n    // TODO: Make this extensible, to let arbitrary back-ends know that\n    // something has changed\n    if (global.Shiny && global.Shiny.onInputChange) {\n      global.Shiny.onInputChange(\n        \".clientValue-\" +\n          (this._group.name !== null ? this._group.name + \"-\" : \"\") +\n          this._name,\n        typeof(value) === \"undefined\" ? null : value\n      );\n    }\n  }\n\n  on(eventType, listener) {\n    return this._events.on(eventType, listener);\n  }\n\n  off(eventType, listener) {\n    return this._events.off(eventType, listener);\n  }\n}\n"
+  ]
+}
\ No newline at end of file
diff --git a/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/js/crosstalk.min.js b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/js/crosstalk.min.js
new file mode 100644
index 0000000..b7ec0ac
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/js/crosstalk.min.js
@@ -0,0 +1,2 @@
+!function o(u,a,l){function s(n,e){if(!a[n]){if(!u[n]){var t="function"==typeof require&&require;if(!e&&t)return t(n,!0);if(f)return f(n,!0);var r=new Error("Cannot find module '"+n+"'");throw r.code="MODULE_NOT_FOUND",r}var i=a[n]={exports:{}};u[n][0].call(i.exports,function(e){var t=u[n][1][e];return s(t||e)},i,i.exports,o,u,a,l)}return a[n].exports}for(var f="function"==typeof require&&require,e=0;e<l.length;e++)s(l[e]);return s}({1:[function(e,t,n){"use strict";Object.defineProperty(n,"__esModule",{value:!0});var r=function(){function r(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(e,t,n){return t&&r(e.prototype,t),n&&r(e,n),e}}();var i=function(){function e(){!function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}(this,e),this._types={},this._seq=0}return r(e,[{key:"on",value:function(e,t){var n=this._types[e];n||(n=this._types[e]={});var r="sub"+this._seq++;return n[r]=t,r}},{key:"off",value:function(e,t){var n=this._types[e];if("function"==typeof t){for(var r in n)if(n.hasOwnProperty(r)&&n[r]===t)return delete n[r],r;return!1}if("string"==typeof t)return!(!n||!n[t])&&(delete n[t],t);throw new Error("Unexpected type for listener")}},{key:"trigger",value:function(e,t,n){var r=this._types[e];for(var i in r)r.hasOwnProperty(i)&&r[i].call(n,t)}}]),e}();n.default=i},{}],2:[function(e,t,n){"use strict";Object.defineProperty(n,"__esModule",{value:!0}),n.FilterHandle=void 0;var r=function(){function r(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(e,t,n){return t&&r(e.prototype,t),n&&r(e,n),e}}(),i=l(e("./events")),o=l(e("./filterset")),u=l(e("./group")),a=function(e){{if(e&&e.__esModule)return e;var t={};if(null!=e)for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&(t[n]=e[n]);return t.default=e,t}}(e("./util"));function l(e){return e&&e.__esModule?e:{default:e}}var s=1;n.FilterHandle=function(){function n(e,t){!function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}(this,n),this._eventRelay=new i.default,this._emitter=new a.SubscriptionTracker(this._eventRelay),this._group=null,this._filterSet=null,this._filterVar=null,this._varOnChangeSub=null,this._extraInfo=a.extend({sender:this},t),this._id="filter"+s++,this.setGroup(e)}return r(n,[{key:"setGroup",value:function(e){var t,n,r=this;if(this._group!==e&&((this._group||e)&&(this._filterVar&&(this._filterVar.off("change",this._varOnChangeSub),this.clear(),this._varOnChangeSub=null,this._filterVar=null,this._filterSet=null),this._group=e))){e=(0,u.default)(e),this._filterSet=(t=e.var("filterset"),(n=t.get())||(n=new o.default,t.set(n)),n),this._filterVar=(0,u.default)(e).var("filter");var i=this._filterVar.on("change",function(e){r._eventRelay.trigger("change",e,r)});this._varOnChangeSub=i}}},{key:"_mergeExtraInfo",value:function(e){return a.extend({},this._extraInfo?this._extraInfo:null,e||null)}},{key:"close",value:function(){this._emitter.removeAllListeners(),this.clear(),this.setGroup(null)}},{key:"clear",value:function(e){this._filterSet&&(this._filterSet.clear(this._id),this._onChange(e))}},{key:"set",value:function(e,t){this._filterSet&&(this._filterSet.update(this._id,e),this._onChange(t))}},{key:"on",value:function(e,t){return this._emitter.on(e,t)}},{key:"off",value:function(e,t){return this._emitter.off(e,t)}},{key:"_onChange",value:function(e){this._filterSet&&this._filterVar.set(this._filterSet.value,this._mergeExtraInfo(e))}},{key:"filteredKeys",get:function(){return this._filterSet?this._filterSet.value:null}}]),n}()},{"./events":1,"./filterset":3,"./group":4,"./util":11}],3:[function(e,t,n){"use strict";Object.defineProperty(n,"__esModule",{value:!0});var r=function(){function r(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(e,t,n){return t&&r(e.prototype,t),n&&r(e,n),e}}(),a=e("./util");function l(e,t){return e===t?0:e<t?-1:t<e?1:void 0}var i=function(){function e(){!function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}(this,e),this.reset()}return r(e,[{key:"reset",value:function(){this._handles={},this._keys={},this._value=null,this._activeHandles=0}},{key:"update",value:function(e,t){null!==t&&(t=t.slice(0)).sort(l);var n=(0,a.diffSortedLists)(this._handles[e],t),r=n.added,i=n.removed;this._handles[e]=t;for(var o=0;o<r.length;o++)this._keys[r[o]]=(this._keys[r[o]]||0)+1;for(var u=0;u<i.length;u++)this._keys[i[u]]--;this._updateValue(t)}},{key:"_updateValue",value:function(){var e=0<arguments.length&&void 0!==arguments[0]?arguments[0]:this._allKeys,t=Object.keys(this._handles).length;if(0===t)this._value=null;else{this._value=[];for(var n=0;n<e.length;n++){this._keys[e[n]]===t&&this._value.push(e[n])}}}},{key:"clear",value:function(e){if(void 0!==this._handles[e]){var t=this._handles[e];t||(t=[]);for(var n=0;n<t.length;n++)this._keys[t[n]]--;delete this._handles[e],this._updateValue()}}},{key:"value",get:function(){return this._value}},{key:"_allKeys",get:function(){var e=Object.keys(this._keys);return e.sort(l),e}}]),e}();n.default=i},{"./util":11}],4:[function(l,e,s){(function(e){"use strict";Object.defineProperty(s,"__esModule",{value:!0});var n=function(){function r(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(e,t,n){return t&&r(e.prototype,t),n&&r(e,n),e}}(),r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e};s.default=function e(t){{if(t&&"string"==typeof t)return u.hasOwnProperty(t)||(u[t]=new a(t)),u[t];if("object"===(void 0===t?"undefined":r(t))&&t._vars&&t.var)return t;if(Array.isArray(t)&&1==t.length&&"string"==typeof t[0])return e(t[0]);throw new Error("Invalid groupName argument")}};var t,i=l("./var"),o=(t=i)&&t.__esModule?t:{default:t};e.__crosstalk_groups=e.__crosstalk_groups||{};var u=e.__crosstalk_groups;var a=function(){function t(e){!function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}(this,t),this.name=e,this._vars={}}return n(t,[{key:"var",value:function(e){if(!e||"string"!=typeof e)throw new Error("Invalid var name");return this._vars.hasOwnProperty(e)||(this._vars[e]=new o.default(this,e)),this._vars[e]}},{key:"has",value:function(e){if(!e||"string"!=typeof e)throw new Error("Invalid var name");return this._vars.hasOwnProperty(e)}}]),t}()}).call(this,"undefined"!=typeof global?global:"undefined"!=typeof self?self:"undefined"!=typeof window?window:{})},{"./var":12}],5:[function(f,e,c){(function(e){"use strict";Object.defineProperty(c,"__esModule",{value:!0});var t,n=f("./group"),r=(t=n)&&t.__esModule?t:{default:t},i=f("./selection"),o=f("./filter"),u=f("./input");f("./input_selectize"),f("./input_checkboxgroup"),f("./input_slider");var a=(0,r.default)("default");function l(e){return a.var(e)}e.Shiny&&e.Shiny.addCustomMessageHandler("update-client-value",function(e){"string"==typeof e.group?(0,r.default)(e.group).var(e.name).set(e.value):l(e.name).set(e.value)});var s={group:r.default,var:l,has:function(e){return a.has(e)},SelectionHandle:i.SelectionHandle,FilterHandle:o.FilterHandle,bind:u.bind};c.default=s,e.crosstalk=s}).call(this,"undefined"!=typeof global?global:"undefined"!=typeof self?self:"undefined"!=typeof window?window:{})},{"./filter":2,"./group":4,"./input":6,"./input_checkboxgroup":7,"./input_selectize":8,"./input_slider":9,"./selection":10}],6:[function(e,t,a){(function(t){"use strict";Object.defineProperty(a,"__esModule",{value:!0}),a.register=function(e){r[e.className]=e,t.document&&"complete"!==t.document.readyState?o(function(){n()}):t.document&&setTimeout(n,100)},a.bind=n;var o=t.jQuery,r={};function n(){Object.keys(r).forEach(function(e){var n=r[e];o("."+n.className).not(".crosstalk-input-bound").each(function(e,t){i(n,t)})})}function i(e,t){var n=o(t).find("script[type='application/json'][data-for='"+t.id.replace(/([!"#$%&'()*+,./:;<=>?@[\\\]^`{|}~])/g,"\\$1")+"']"),r=JSON.parse(n[0].innerText),i=e.factory(t,r);o(t).data("crosstalk-instance",i),o(t).addClass("crosstalk-input-bound")}if(t.Shiny){var e=new t.Shiny.InputBinding,u=t.jQuery;u.extend(e,{find:function(e){return u(e).find(".crosstalk-input")},initialize:function(e){var t,n;u(e).hasClass("crosstalk-input-bound")||(n=o(t=e),Object.keys(r).forEach(function(e){n.hasClass(e)&&!n.hasClass("crosstalk-input-bound")&&i(r[e],t)}))},getId:function(e){return e.id},getValue:function(e){},setValue:function(e,t){},receiveMessage:function(e,t){},subscribe:function(e,t){u(e).data("crosstalk-instance").resume()},unsubscribe:function(e){u(e).data("crosstalk-instance").suspend()}}),t.Shiny.inputBindings.register(e,"crosstalk.inputBinding")}}).call(this,"undefined"!=typeof global?global:"undefined"!=typeof self?self:"undefined"!=typeof window?window:{})},{}],7:[function(r,e,t){(function(e){"use strict";var t=function(e){{if(e&&e.__esModule)return e;var t={};if(null!=e)for(var n in e)Object.prototype.hasOwnProperty.call(e,n)&&(t[n]=e[n]);return t.default=e,t}}(r("./input")),n=r("./filter");var a=e.jQuery;t.register({className:"crosstalk-input-checkboxgroup",factory:function(e,r){var i=new n.FilterHandle(r.group),o=void 0,u=a(e);return 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e(t,n,r){function s(o,u){if(!n[o]){if(!t[o]){var a=typeof require==\"function\"&&require;if(!u&&a)return a(o,!0);if(i)return i(o,!0);var f=new Error(\"Cannot find module '\"+o+\"'\");throw f.code=\"MODULE_NOT_FOUND\",f}var l=n[o]={exports:{}};t[o][0].call(l.exports,function(e){var n=t[o][1][e];return s(n?n:e)},l,l.exports,e,t,n,r)}return n[o].exports}var i=typeof require==\"function\"&&require;for(var o=0;o<r.length;o++)s(r[o]);return s}return e})()","export default class Events {\n  constructor() {\n    this._types = {};\n    this._seq = 0;\n  }\n\n  on(eventType, listener) {\n    let subs = this._types[eventType];\n    if (!subs) {\n      subs = this._types[eventType] = {};\n    }\n    let sub = \"sub\" + (this._seq++);\n    subs[sub] = listener;\n    return sub;\n  }\n\n  // Returns false if no match, or string for sub name if matched\n  off(eventType, listener) {\n    let subs = this._types[eventType];\n    if (typeof(listener) === \"function\") {\n      for (let key in subs) {\n        if (subs.hasOwnProperty(key)) {\n          if (subs[key] === listener) {\n            delete subs[key];\n            return key;\n          }\n        }\n      }\n      return false;\n    } else if (typeof(listener) === \"string\") {\n      if (subs && subs[listener]) {\n        delete subs[listener];\n        return listener;\n      }\n      return false;\n    } else {\n      throw new Error(\"Unexpected type for listener\");\n    }\n  }\n\n  trigger(eventType, arg, thisObj) {\n    let subs = this._types[eventType];\n    for (let key in subs) {\n      if (subs.hasOwnProperty(key)) {\n        subs[key].call(thisObj, arg);\n      }\n    }\n  }\n}\n","import Events from \"./events\";\nimport FilterSet from \"./filterset\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\nfunction getFilterSet(group) {\n  let fsVar = group.var(\"filterset\");\n  let result = fsVar.get();\n  if (!result) {\n    result = new FilterSet();\n    fsVar.set(result);\n  }\n  return result;\n}\n\nlet id = 1;\nfunction nextId() {\n  return id++;\n}\n\n/**\n * Use this class to contribute to, and listen for changes to, the filter set\n * for the given group of widgets. Filter input controls should create one\n * `FilterHandle` and only call {@link FilterHandle#set}. Output widgets that\n * wish to displayed filtered data should create one `FilterHandle` and use\n * the {@link FilterHandle#filteredKeys} property and listen for change\n * events.\n *\n * If two (or more) `FilterHandle` instances in the same webpage share the\n * same group name, they will contribute to a single \"filter set\". Each\n * `FilterHandle` starts out with a `null` value, which means they take\n * nothing away from the set of data that should be shown. To make a\n * `FilterHandle` actually remove data from the filter set, set its value to\n * an array of keys which should be displayed. Crosstalk will aggregate the\n * various key arrays by finding their intersection; only keys that are\n * present in all non-null filter handles are considered part of the filter\n * set.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the {@link FilterHandle#setGroup} method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class FilterHandle {\n  constructor(group, extraInfo) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The filterSet that we're tracking, if any. Can change over time.\n    this._filterSet = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._filterVar = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this._id = \"filter\" + nextId();\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this FilterHandle. If `set()` was\n   * previously called on this handle, switching groups will clear those keys\n   * from the old group's filter set. These keys will not be applied to the new\n   * group's filter set either. In other words, `setGroup()` effectively calls\n   * `clear()` before switching groups.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._filterVar) {\n      this._filterVar.off(\"change\", this._varOnChangeSub);\n      this.clear();\n      this._varOnChangeSub = null;\n      this._filterVar = null;\n      this._filterSet = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      group = grp(group);\n      this._filterSet = getFilterSet(group);\n      this._filterVar = grp(group).var(\"filter\");\n      let sub = this._filterVar.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Combine the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Close the handle. This clears this handle's contribution to the filter set,\n   * and unsubscribes all event listeners.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.clear();\n    this.setGroup(null);\n  }\n\n  /**\n   * Clear this handle's contribution to the filter set.\n   *\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  clear(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.clear(this._id);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * Set this handle's contribution to the filter set. This array should consist\n   * of the keys of the rows that _should_ be displayed; any keys that are not\n   * present in the array will be considered _filtered out_. Note that multiple\n   * `FilterHandle` instances in the group may each contribute an array of keys,\n   * and only those keys that appear in _all_ of the arrays make it through the\n   * filter.\n   *\n   * @param {string[]} keys - Empty array, or array of keys. To clear the\n   *   filter, don't pass an empty array; instead, use the\n   *   {@link FilterHandle#clear} method.\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `FilterHandle` constructor).\n   * \n   * @fires FilterHandle#change\n   */\n  set(keys, extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterSet.update(this._id, keys);\n    this._onChange(extraInfo);\n  }\n\n  /**\n   * @return {string[]|null} - Either: 1) an array of keys that made it through\n   *   all of the `FilterHandle` instances, or, 2) `null`, which means no filter\n   *   is being applied (all data should be displayed).\n   */\n  get filteredKeys() {\n    return this._filterSet ? this._filterSet.value : null;\n  }\n\n  /**\n   * Subscribe to events on this `FilterHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {FilterHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link FilterHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancel event subscriptions created by {@link FilterHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|FilterHandle~listener} listener - Either the callback\n   *   function previously passed into {@link FilterHandle#on}, or the\n   *   string that was returned from {@link FilterHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  _onChange(extraInfo) {\n    if (!this._filterSet)\n      return;\n    this._filterVar.set(this._filterSet.value, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * @callback FilterHandle~listener\n   * @param {Object} event - An object containing details of the event. For\n   *   `\"change\"` events, this includes the properties `value` (the new\n   *   value of the filter set, or `null` if no filter set is active),\n   *   `oldValue` (the previous value of the filter set), and `sender` (the\n   *   `FilterHandle` instance that made the change).\n   */\n\n}\n\n/**\n * @event FilterHandle#change\n * @type {object}\n * @property {object} value - The new value of the filter set, or `null`\n *   if no filter set is active.\n * @property {object} oldValue - The previous value of the filter set.\n * @property {FilterHandle} sender - The `FilterHandle` instance that\n *   changed the value.\n */\n","import { diffSortedLists } from \"./util\";\n\nfunction naturalComparator(a, b) {\n  if (a === b) {\n    return 0;\n  } else if (a < b) {\n    return -1;\n  } else if (a > b) {\n    return 1;\n  }\n}\n\n/**\n * @private\n */\nexport default class FilterSet {\n  constructor() {\n    this.reset();\n  }\n\n  reset() {\n    // Key: handle ID, Value: array of selected keys, or null\n    this._handles = {};\n    // Key: key string, Value: count of handles that include it\n    this._keys = {};\n    this._value = null;\n    this._activeHandles = 0;\n  }\n\n  get value() {\n    return this._value;\n  }\n\n  update(handleId, keys) {\n    if (keys !== null) {\n      keys = keys.slice(0); // clone before sorting\n      keys.sort(naturalComparator);\n    }\n\n    let {added, removed} = diffSortedLists(this._handles[handleId], keys);\n    this._handles[handleId] = keys;\n\n    for (let i = 0; i < added.length; i++) {\n      this._keys[added[i]] = (this._keys[added[i]] || 0) + 1;\n    }\n    for (let i = 0; i < removed.length; i++) {\n      this._keys[removed[i]]--;\n    }\n\n    this._updateValue(keys);\n  }\n\n  /**\n   * @param {string[]} keys Sorted array of strings that indicate\n   * a superset of possible keys.\n   * @private\n   */\n  _updateValue(keys = this._allKeys) {\n    let handleCount = Object.keys(this._handles).length;\n    if (handleCount === 0) {\n      this._value = null;\n    } else {\n      this._value = [];\n      for (let i = 0; i < keys.length; i++) {\n        let count = this._keys[keys[i]];\n        if (count === handleCount) {\n          this._value.push(keys[i]);\n        }\n      }\n    }\n  }\n\n  clear(handleId) {\n    if (typeof(this._handles[handleId]) === \"undefined\") {\n      return;\n    }\n\n    let keys = this._handles[handleId];\n    if (!keys) {\n      keys = [];\n    }\n\n    for (let i = 0; i < keys.length; i++) {\n      this._keys[keys[i]]--;\n    }\n    delete this._handles[handleId];\n\n    this._updateValue();\n  }\n\n  get _allKeys() {\n    let allKeys = Object.keys(this._keys);\n    allKeys.sort(naturalComparator);\n    return allKeys;\n  }\n}\n","import Var from \"./var\";\n\n// Use a global so that multiple copies of crosstalk.js can be loaded and still\n// have groups behave as singletons across all copies.\nglobal.__crosstalk_groups = global.__crosstalk_groups || {};\nlet groups = global.__crosstalk_groups;\n\nexport default function group(groupName) {\n  if (groupName && typeof(groupName) === \"string\") {\n    if (!groups.hasOwnProperty(groupName)) {\n      groups[groupName] = new Group(groupName);\n    }\n    return groups[groupName];\n  } else if (typeof(groupName) === \"object\" && groupName._vars && groupName.var) {\n    // Appears to already be a group object\n    return groupName;\n  } else if (Array.isArray(groupName) &&\n      groupName.length == 1 &&\n      typeof(groupName[0]) === \"string\") {\n    return group(groupName[0]);\n  } else {\n    throw new Error(\"Invalid groupName argument\");\n  }\n}\n\nclass Group {\n  constructor(name) {\n    this.name = name;\n    this._vars = {};\n  }\n\n  var(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    if (!this._vars.hasOwnProperty(name))\n      this._vars[name] = new Var(this, name);\n    return this._vars[name];\n  }\n\n  has(name) {\n    if (!name || typeof(name) !== \"string\") {\n      throw new Error(\"Invalid var name\");\n    }\n\n    return this._vars.hasOwnProperty(name);\n  }\n}\n","import group from \"./group\";\nimport { SelectionHandle } from \"./selection\";\nimport { FilterHandle } from \"./filter\";\nimport { bind } from \"./input\";\nimport \"./input_selectize\";\nimport \"./input_checkboxgroup\";\nimport \"./input_slider\";\n\nconst defaultGroup = group(\"default\");\n\nfunction var_(name) {\n  return defaultGroup.var(name);\n}\n\nfunction has(name) {\n  return defaultGroup.has(name);\n}\n\nif (global.Shiny) {\n  global.Shiny.addCustomMessageHandler(\"update-client-value\", function(message) {\n    if (typeof(message.group) === \"string\") {\n      group(message.group).var(message.name).set(message.value);\n    } else {\n      var_(message.name).set(message.value);\n    }\n  });\n}\n\nconst crosstalk = {\n  group: group,\n  var: var_,\n  has: has,\n  SelectionHandle: SelectionHandle,\n  FilterHandle: FilterHandle,\n  bind: bind\n};\n\n/**\n * @namespace crosstalk\n */\nexport default crosstalk;\nglobal.crosstalk = crosstalk;\n","let $ = global.jQuery;\n\nlet bindings = {};\n\nexport function register(reg) {\n  bindings[reg.className] = reg;\n  if (global.document && global.document.readyState !== \"complete\") {\n    $(() => {\n      bind();\n    });\n  } else if (global.document) {\n    setTimeout(bind, 100);\n  }\n}\n\nexport function bind() {\n  Object.keys(bindings).forEach(function(className) {\n    let binding = bindings[className];\n    $(\".\" + binding.className).not(\".crosstalk-input-bound\").each(function(i, el) {\n      bindInstance(binding, el);\n    });\n  });\n}\n\n// Escape jQuery identifier\nfunction $escape(val) {\n  return val.replace(/([!\"#$%&'()*+,./:;<=>?@[\\\\\\]^`{|}~])/g, \"\\\\$1\");\n}\n\nfunction bindEl(el) {\n  let $el = $(el);\n  Object.keys(bindings).forEach(function(className) {\n    if ($el.hasClass(className) && !$el.hasClass(\"crosstalk-input-bound\")) {\n      let binding = bindings[className];\n      bindInstance(binding, el);\n    }\n  });\n}\n\nfunction bindInstance(binding, el) {\n  let jsonEl = $(el).find(\"script[type='application/json'][data-for='\" + $escape(el.id) + \"']\");\n  let data = JSON.parse(jsonEl[0].innerText);\n\n  let instance = binding.factory(el, data);\n  $(el).data(\"crosstalk-instance\", instance);\n  $(el).addClass(\"crosstalk-input-bound\");\n}\n\nif (global.Shiny) {\n  let inputBinding = new global.Shiny.InputBinding();\n  let $ = global.jQuery;\n  $.extend(inputBinding, {\n    find: function(scope) {\n      return $(scope).find(\".crosstalk-input\");\n    },\n    initialize: function(el) {\n      if (!$(el).hasClass(\"crosstalk-input-bound\")) {\n        bindEl(el);\n      }\n    },\n    getId: function(el) {\n      return el.id;\n    },\n    getValue: function(el) {\n\n    },\n    setValue: function(el, value) {\n\n    },\n    receiveMessage: function(el, data) {\n\n    },\n    subscribe: function(el, callback) {\n      $(el).data(\"crosstalk-instance\").resume();\n    },\n    unsubscribe: function(el) {\n      $(el).data(\"crosstalk-instance\").suspend();\n    }\n  });\n  global.Shiny.inputBindings.register(inputBinding, \"crosstalk.inputBinding\");\n}\n","import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-checkboxgroup\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    let $el = $(el);\n    $el.on(\"change\", \"input[type='checkbox']\", function() {\n      let checked = $el.find(\"input[type='checkbox']:checked\");\n      if (checked.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        checked.each(function() {\n          data.map[this.value].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n","import * as input from \"./input\";\nimport * as util from \"./util\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\n\ninput.register({\n  className: \"crosstalk-input-select\",\n\n  factory: function(el, data) {\n    /*\n     * items: {value: [...], label: [...]}\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n\n    let first = [{value: \"\", label: \"(All)\"}];\n    let items = util.dataframeToD3(data.items);\n    let opts = {\n      options: first.concat(items),\n      valueField: \"value\",\n      labelField: \"label\",\n      searchField: \"label\"\n    };\n\n    let select = $(el).find(\"select\")[0];\n\n    let selectize = $(select).selectize(opts)[0].selectize;\n\n    let ctHandle = new FilterHandle(data.group);\n\n    let lastKnownKeys;\n    selectize.on(\"change\", function() {\n      if (selectize.items.length === 0) {\n        lastKnownKeys = null;\n        ctHandle.clear();\n      } else {\n        let keys = {};\n        selectize.items.forEach(function(group) {\n          data.map[group].forEach(function(key) {\n            keys[key] = true;\n          });\n        });\n        let keyArray = Object.keys(keys);\n        keyArray.sort();\n        lastKnownKeys = keyArray;\n        ctHandle.set(keyArray);\n      }\n    });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n","import * as input from \"./input\";\nimport { FilterHandle } from \"./filter\";\n\nlet $ = global.jQuery;\nlet strftime = global.strftime;\n\ninput.register({\n  className: \"crosstalk-input-slider\",\n\n  factory: function(el, data) {\n    /*\n     * map: {\"groupA\": [\"keyA\", \"keyB\", ...], ...}\n     * group: \"ct-groupname\"\n     */\n    let ctHandle = new FilterHandle(data.group);\n\n    let opts = {};\n    let $el = $(el).find(\"input\");\n    let dataType = $el.data(\"data-type\");\n    let timeFormat = $el.data(\"time-format\");\n    let round = $el.data(\"round\");\n    let timeFormatter;\n\n    // Set up formatting functions\n    if (dataType === \"date\") {\n      timeFormatter = strftime.utc();\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n\n    } else if (dataType === \"datetime\") {\n      let timezone = $el.data(\"timezone\");\n      if (timezone)\n        timeFormatter = strftime.timezone(timezone);\n      else\n        timeFormatter = strftime;\n\n      opts.prettify = function(num) {\n        return timeFormatter(timeFormat, new Date(num));\n      };\n    } else if (dataType === \"number\") {\n      if (typeof round !== \"undefined\")\n        opts.prettify = function(num) {\n          let factor = Math.pow(10, round);\n          return Math.round(num * factor) / factor;\n        };\n    }\n\n    $el.ionRangeSlider(opts);\n\n    function getValue() {\n      let result = $el.data(\"ionRangeSlider\").result;\n\n      // Function for converting numeric value from slider to appropriate type.\n      let convert;\n      let dataType = $el.data(\"data-type\");\n      if (dataType === \"date\") {\n        convert = function(val) {\n          return formatDateUTC(new Date(+val));\n        };\n      } else if (dataType === \"datetime\") {\n        convert = function(val) {\n          // Convert ms to s\n          return +val / 1000;\n        };\n      } else {\n        convert = function(val) { return +val; };\n      }\n\n      if ($el.data(\"ionRangeSlider\").options.type === \"double\") {\n        return [convert(result.from), convert(result.to)];\n      } else {\n        return convert(result.from);\n      }\n    }\n\n    let lastKnownKeys = null;\n\n    $el.on(\"change.crosstalkSliderInput\", function(event) {\n      if (!$el.data(\"updating\") && !$el.data(\"animating\")) {\n        let [from, to] = getValue();\n        let keys = [];\n        for (let i = 0; i < data.values.length; i++) {\n          let val = data.values[i];\n          if (val >= from && val <= to) {\n            keys.push(data.keys[i]);\n          }\n        }\n        keys.sort();\n        ctHandle.set(keys);\n        lastKnownKeys = keys;\n      }\n    });\n\n\n    // let $el = $(el);\n    // $el.on(\"change\", \"input[type=\"checkbox\"]\", function() {\n    //   let checked = $el.find(\"input[type=\"checkbox\"]:checked\");\n    //   if (checked.length === 0) {\n    //     ctHandle.clear();\n    //   } else {\n    //     let keys = {};\n    //     checked.each(function() {\n    //       data.map[this.value].forEach(function(key) {\n    //         keys[key] = true;\n    //       });\n    //     });\n    //     let keyArray = Object.keys(keys);\n    //     keyArray.sort();\n    //     ctHandle.set(keyArray);\n    //   }\n    // });\n\n    return {\n      suspend: function() {\n        ctHandle.clear();\n      },\n      resume: function() {\n        if (lastKnownKeys)\n          ctHandle.set(lastKnownKeys);\n      }\n    };\n  }\n});\n\n\n// Convert a number to a string with leading zeros\nfunction padZeros(n, digits) {\n  let str = n.toString();\n  while (str.length < digits)\n    str = \"0\" + str;\n  return str;\n}\n\n// Given a Date object, return a string in yyyy-mm-dd format, using the\n// UTC date. This may be a day off from the date in the local time zone.\nfunction formatDateUTC(date) {\n  if (date instanceof Date) {\n    return date.getUTCFullYear() + \"-\" +\n           padZeros(date.getUTCMonth()+1, 2) + \"-\" +\n           padZeros(date.getUTCDate(), 2);\n\n  } else {\n    return null;\n  }\n}\n","import Events from \"./events\";\nimport grp from \"./group\";\nimport * as util from \"./util\";\n\n/**\n * Use this class to read and write (and listen for changes to) the selection\n * for a Crosstalk group. This is intended to be used for linked brushing.\n *\n * If two (or more) `SelectionHandle` instances in the same webpage share the\n * same group name, they will share the same state. Setting the selection using\n * one `SelectionHandle` instance will result in the `value` property instantly\n * changing across the others, and `\"change\"` event listeners on all instances\n * (including the one that initiated the sending) will fire.\n *\n * @param {string} [group] - The name of the Crosstalk group, or if none,\n *   null or undefined (or any other falsy value). This can be changed later\n *   via the [SelectionHandle#setGroup](#setGroup) method.\n * @param {Object} [extraInfo] - An object whose properties will be copied to\n *   the event object whenever an event is emitted.\n */\nexport class SelectionHandle {\n\n  constructor(group = null, extraInfo = null) {\n    this._eventRelay = new Events();\n    this._emitter = new util.SubscriptionTracker(this._eventRelay);\n\n    // Name of the group we're currently tracking, if any. Can change over time.\n    this._group = null;\n    // The Var we're currently tracking, if any. Can change over time.\n    this._var = null;\n    // The event handler subscription we currently have on var.on(\"change\").\n    this._varOnChangeSub = null;\n\n    this._extraInfo = util.extend({ sender: this }, extraInfo);\n\n    this.setGroup(group);\n  }\n\n  /**\n   * Changes the Crosstalk group membership of this SelectionHandle. The group\n   * being switched away from (if any) will not have its selection value\n   * modified as a result of calling `setGroup`, even if this handle was the\n   * most recent handle to set the selection of the group.\n   *\n   * The group being switched to (if any) will also not have its selection value\n   * modified as a result of calling `setGroup`. If you want to set the\n   * selection value of the new group, call `set` explicitly.\n   *\n   * @param {string} group - The name of the Crosstalk group, or null (or\n   *   undefined) to clear the group.\n   */\n  setGroup(group) {\n    // If group is unchanged, do nothing\n    if (this._group === group)\n      return;\n    // Treat null, undefined, and other falsy values the same\n    if (!this._group && !group)\n      return;\n\n    if (this._var) {\n      this._var.off(\"change\", this._varOnChangeSub);\n      this._var = null;\n      this._varOnChangeSub = null;\n    }\n\n    this._group = group;\n\n    if (group) {\n      this._var = grp(group).var(\"selection\");\n      let sub = this._var.on(\"change\", (e) => {\n        this._eventRelay.trigger(\"change\", e, this);\n      });\n      this._varOnChangeSub = sub;\n    }\n  }\n\n  /**\n   * Retrieves the current selection for the group represented by this\n   * `SelectionHandle`.\n   *\n   * - If no selection is active, then this value will be falsy.\n   * - If a selection is active, but no data points are selected, then this\n   *   value will be an empty array.\n   * - If a selection is active, and data points are selected, then the keys\n   *   of the selected data points will be present in the array.\n   */\n  get value() {\n    return this._var ? this._var.get() : null;\n  }\n\n  /**\n   * Combines the given `extraInfo` (if any) with the handle's default\n   * `_extraInfo` (if any).\n   * @private\n   */\n  _mergeExtraInfo(extraInfo) {\n    // Important incidental effect: shallow clone is returned\n    return util.extend({},\n      this._extraInfo ? this._extraInfo : null,\n      extraInfo ? extraInfo : null);\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {string[]} selectedKeys - Falsy, empty array, or array of keys (see\n   *   {@link SelectionHandle#value}).\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any options that were\n   *   passed into the `SelectionHandle` constructor).\n   */\n  set(selectedKeys, extraInfo) {\n    if (this._var)\n      this._var.set(selectedKeys, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Overwrites the current selection for the group, and raises the `\"change\"`\n   * event among all of the group's '`SelectionHandle` instances (including\n   * this one).\n   *\n   * @fires SelectionHandle#change\n   * @param {Object} [extraInfo] - Extra properties to be included on the event\n   *   object that's passed to listeners (in addition to any that were passed\n   *   into the `SelectionHandle` constructor).\n   */\n  clear(extraInfo) {\n    if (this._var)\n      this.set(void 0, this._mergeExtraInfo(extraInfo));\n  }\n\n  /**\n   * Subscribes to events on this `SelectionHandle`.\n   *\n   * @param {string} eventType - Indicates the type of events to listen to.\n   *   Currently, only `\"change\"` is supported.\n   * @param {SelectionHandle~listener} listener - The callback function that\n   *   will be invoked when the event occurs.\n   * @return {string} - A token to pass to {@link SelectionHandle#off} to cancel\n   *   this subscription.\n   */\n  on(eventType, listener) {\n    return this._emitter.on(eventType, listener);\n  }\n\n  /**\n   * Cancels event subscriptions created by {@link SelectionHandle#on}.\n   *\n   * @param {string} eventType - The type of event to unsubscribe.\n   * @param {string|SelectionHandle~listener} listener - Either the callback\n   *   function previously passed into {@link SelectionHandle#on}, or the\n   *   string that was returned from {@link SelectionHandle#on}.\n   */\n  off(eventType, listener) {\n    return this._emitter.off(eventType, listener);\n  }\n\n  /**\n   * Shuts down the `SelectionHandle` object.\n   *\n   * Removes all event listeners that were added through this handle.\n   */\n  close() {\n    this._emitter.removeAllListeners();\n    this.setGroup(null);\n  }\n}\n\n/**\n * @callback SelectionHandle~listener\n * @param {Object} event - An object containing details of the event. For\n *   `\"change\"` events, this includes the properties `value` (the new\n *   value of the selection, or `undefined` if no selection is active),\n *   `oldValue` (the previous value of the selection), and `sender` (the\n *   `SelectionHandle` instance that made the change).\n */\n\n/**\n * @event SelectionHandle#change\n * @type {object}\n * @property {object} value - The new value of the selection, or `undefined`\n *   if no selection is active.\n * @property {object} oldValue - The previous value of the selection.\n * @property {SelectionHandle} sender - The `SelectionHandle` instance that\n *   changed the value.\n */\n","export function extend(target, ...sources) {\n  for (let i = 0; i < sources.length; i++) {\n    let src = sources[i];\n    if (typeof(src) === \"undefined\" || src === null)\n      continue;\n\n    for (let key in src) {\n      if (src.hasOwnProperty(key)) {\n        target[key] = src[key];\n      }\n    }\n  }\n  return target;\n}\n\nexport function checkSorted(list) {\n  for (let i = 1; i < list.length; i++) {\n    if (list[i] <= list[i-1]) {\n      throw new Error(\"List is not sorted or contains duplicate\");\n    }\n  }\n}\n\nexport function diffSortedLists(a, b) {\n  let i_a = 0;\n  let i_b = 0;\n\n  if (!a) a = [];\n  if (!b) b = [];\n\n  let a_only = [];\n  let b_only = [];\n\n  checkSorted(a);\n  checkSorted(b);\n\n  while (i_a < a.length && i_b < b.length) {\n    if (a[i_a] === b[i_b]) {\n      i_a++;\n      i_b++;\n    } else if (a[i_a] < b[i_b]) {\n      a_only.push(a[i_a++]);\n    } else {\n      b_only.push(b[i_b++]);\n    }\n  }\n\n  if (i_a < a.length)\n    a_only = a_only.concat(a.slice(i_a));\n  if (i_b < b.length)\n    b_only = b_only.concat(b.slice(i_b));\n  return {\n    removed: a_only,\n    added: b_only\n  };\n}\n\n// Convert from wide: { colA: [1,2,3], colB: [4,5,6], ... }\n// to long: [ {colA: 1, colB: 4}, {colA: 2, colB: 5}, ... ]\nexport function dataframeToD3(df) {\n  let names = [];\n  let length;\n  for (let name in df) {\n    if (df.hasOwnProperty(name))\n      names.push(name);\n    if (typeof(df[name]) !== \"object\" || typeof(df[name].length) === \"undefined\") {\n      throw new Error(\"All fields must be arrays\");\n    } else if (typeof(length) !== \"undefined\" && length !== df[name].length) {\n      throw new Error(\"All fields must be arrays of the same length\");\n    }\n    length = df[name].length;\n  }\n  let results = [];\n  let item;\n  for (let row = 0; row < length; row++) {\n    item = {};\n    for (let col = 0; col < names.length; col++) {\n      item[names[col]] = df[names[col]][row];\n    }\n    results.push(item);\n  }\n  return results;\n}\n\n/**\n * Keeps track of all event listener additions/removals and lets all active\n * listeners be removed with a single operation.\n *\n * @private\n */\nexport class SubscriptionTracker {\n  constructor(emitter) {\n    this._emitter = emitter;\n    this._subs = {};\n  }\n\n  on(eventType, listener) {\n    let sub = this._emitter.on(eventType, listener);\n    this._subs[sub] = eventType;\n    return sub;\n  }\n\n  off(eventType, listener) {\n    let sub = this._emitter.off(eventType, listener);\n    if (sub) {\n      delete this._subs[sub];\n    }\n    return sub;\n  }\n\n  removeAllListeners() {\n    let current_subs = this._subs;\n    this._subs = {};\n    Object.keys(current_subs).forEach((sub) => {\n      this._emitter.off(current_subs[sub], sub);\n    });\n  }\n}\n","import Events from \"./events\";\n\nexport default class Var {\n  constructor(group, name, /*optional*/ value) {\n    this._group = group;\n    this._name = name;\n    this._value = value;\n    this._events = new Events();\n  }\n\n  get() {\n    return this._value;\n  }\n\n  set(value, /*optional*/ event) {\n    if (this._value === value) {\n      // Do nothing; the value hasn't changed\n      return;\n    }\n    let oldValue = this._value;\n    this._value = value;\n    // Alert JavaScript listeners that the value has changed\n    let evt = {};\n    if (event && typeof(event) === \"object\") {\n      for (let k in event) {\n        if (event.hasOwnProperty(k))\n          evt[k] = event[k];\n      }\n    }\n    evt.oldValue = oldValue;\n    evt.value = value;\n    this._events.trigger(\"change\", evt, this);\n\n    // TODO: Make this extensible, to let arbitrary back-ends know that\n    // something has changed\n    if (global.Shiny && global.Shiny.onInputChange) {\n      global.Shiny.onInputChange(\n        \".clientValue-\" +\n          (this._group.name !== null ? this._group.name + \"-\" : \"\") +\n          this._name,\n        typeof(value) === \"undefined\" ? null : value\n      );\n    }\n  }\n\n  on(eventType, listener) {\n    return this._events.on(eventType, listener);\n  }\n\n  off(eventType, listener) {\n    return this._events.off(eventType, listener);\n  }\n}\n"]}
\ No newline at end of file
diff --git a/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/scss/crosstalk.scss b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/scss/crosstalk.scss
new file mode 100644
index 0000000..3566561
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/crosstalk-1.2.1/scss/crosstalk.scss
@@ -0,0 +1,75 @@
+/* Adjust margins outwards, so column contents line up with the edges of the
+   parent of container-fluid. */
+.container-fluid.crosstalk-bscols {
+  margin-left: -30px;
+  margin-right: -30px;
+  white-space: normal;
+}
+
+/* But don't adjust the margins outwards if we're directly under the body,
+   i.e. we were the top-level of something at the console. */
+body > .container-fluid.crosstalk-bscols {
+  margin-left: auto;
+  margin-right: auto;
+}
+
+.crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column {
+  display: inline-block;
+  padding-right: 12px;
+  vertical-align: top;
+}
+
+@media only screen and (max-width:480px) {
+  .crosstalk-input-checkboxgroup .crosstalk-options-group .crosstalk-options-column {
+    display: block;
+    padding-right: inherit;
+  }
+}
+
+/* Relevant BS3 styles to make filter_checkbox() look reasonable without Bootstrap */
+.crosstalk-input {
+  margin-bottom: 15px; /* a la .form-group */
+  .control-label {
+    margin-bottom: 0;
+    vertical-align: middle;
+  }
+  input[type="checkbox"] {
+    margin: 4px 0 0;
+    margin-top: 1px;
+    line-height: normal;
+  }
+  .checkbox {
+    position: relative;
+    display: block;
+    margin-top: 10px;
+    margin-bottom: 10px;
+  }
+  .checkbox > label{
+    padding-left: 20px;
+    margin-bottom: 0;
+    font-weight: 400;
+    cursor: pointer;
+  }
+  .checkbox input[type="checkbox"],
+  .checkbox-inline input[type="checkbox"] {
+    position: absolute;
+    margin-top: 2px;
+    margin-left: -20px;
+  }
+  .checkbox + .checkbox {
+    margin-top: -5px;
+  }
+  .checkbox-inline {
+    position: relative;
+    display: inline-block;
+    padding-left: 20px;
+    margin-bottom: 0;
+    font-weight: 400;
+    vertical-align: middle;
+    cursor: pointer;
+  }
+  .checkbox-inline + .checkbox-inline {
+    margin-top: 0;
+    margin-left: 10px;
+  }
+}
diff --git a/docs/articles/S6_hca_onto_files/datatables-binding-0.33/datatables.js b/docs/articles/S6_hca_onto_files/datatables-binding-0.33/datatables.js
new file mode 100644
index 0000000..765b53c
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/datatables-binding-0.33/datatables.js
@@ -0,0 +1,1539 @@
+(function() {
+
+// some helper functions: using a global object DTWidget so that it can be used
+// in JS() code, e.g. datatable(options = list(foo = JS('code'))); unlike R's
+// dynamic scoping, when 'code' is eval'ed, JavaScript does not know objects
+// from the "parent frame", e.g. JS('DTWidget') will not work unless it was made
+// a global object
+var DTWidget = {};
+
+// 123456666.7890 -> 123,456,666.7890
+var markInterval = function(d, digits, interval, mark, decMark, precision) {
+  x = precision ? d.toPrecision(digits) : d.toFixed(digits);
+  if (!/^-?[\d.]+$/.test(x)) return x;
+  var xv = x.split('.');
+  if (xv.length > 2) return x;  // should have at most one decimal point
+  xv[0] = xv[0].replace(new RegExp('\\B(?=(\\d{' + interval + '})+(?!\\d))', 'g'), mark);
+  return xv.join(decMark);
+};
+
+DTWidget.formatCurrency = function(data, currency, digits, interval, mark, decMark, before, zeroPrint) {
+  var d = parseFloat(data);
+  if (isNaN(d)) return '';
+  if (zeroPrint !== null && d === 0.0) return zeroPrint;
+  var res = markInterval(d, digits, interval, mark, decMark);
+  res = before ? (/^-/.test(res) ? '-' + currency + res.replace(/^-/, '') : currency + res) :
+    res + currency;
+  return res;
+};
+
+DTWidget.formatString = function(data, prefix, suffix) {
+  var d = data;
+  if (d === null) return '';
+  return prefix + d + suffix;
+};
+
+DTWidget.formatPercentage = function(data, digits, interval, mark, decMark, zeroPrint) {
+  var d = parseFloat(data);
+  if (isNaN(d)) return '';
+  if (zeroPrint !== null && d === 0.0) return zeroPrint;
+  return markInterval(d * 100, digits, interval, mark, decMark) + '%';
+};
+
+DTWidget.formatRound = function(data, digits, interval, mark, decMark, zeroPrint) {
+  var d = parseFloat(data);
+  if (isNaN(d)) return '';
+  if (zeroPrint !== null && d === 0.0) return zeroPrint;
+  return markInterval(d, digits, interval, mark, decMark);
+};
+
+DTWidget.formatSignif = function(data, digits, interval, mark, decMark, zeroPrint) {
+  var d = parseFloat(data);
+  if (isNaN(d)) return '';
+  if (zeroPrint !== null && d === 0.0) return zeroPrint;
+  return markInterval(d, digits, interval, mark, decMark, true);
+};
+
+DTWidget.formatDate = function(data, method, params) {
+  var d = data;
+  if (d === null) return '';
+  // (new Date('2015-10-28')).toDateString() may return 2015-10-27 because the
+  // actual time created could be like 'Tue Oct 27 2015 19:00:00 GMT-0500 (CDT)',
+  // i.e. the date-only string is treated as UTC time instead of local time
+  if ((method === 'toDateString' || method === 'toLocaleDateString') && /^\d{4,}\D\d{2}\D\d{2}$/.test(d)) {
+    d = d.split(/\D/);
+    d = new Date(d[0], d[1] - 1, d[2]);
+  } else {
+    d = new Date(d);
+  }
+  return d[method].apply(d, params);
+};
+
+window.DTWidget = DTWidget;
+
+// A helper function to update the properties of existing filters
+var setFilterProps = function(td, props) {
+  // Update enabled/disabled state
+  var $input = $(td).find('input').first();
+  var searchable = $input.data('searchable');
+  $input.prop('disabled', !searchable || props.disabled);
+
+  // Based on the filter type, set its new values
+  var type = td.getAttribute('data-type');
+  if (['factor', 'logical'].includes(type)) {
+    // Reformat the new dropdown options for use with selectize
+    var new_vals = props.params.options.map(function(item) {
+      return { text: item, value: item };
+    });
+
+    // Find the selectize object
+    var dropdown = $(td).find('.selectized').eq(0)[0].selectize;
+
+    // Note the current values
+    var old_vals = dropdown.getValue();
+
+    // Remove the existing values
+    dropdown.clearOptions();
+
+    // Add the new options
+    dropdown.addOption(new_vals);
+
+    // Preserve the existing values
+    dropdown.setValue(old_vals);
+
+  } else if (['number', 'integer', 'date', 'time'].includes(type)) {
+    // Apply internal scaling to new limits. Updating scale not yet implemented.
+    var slider = $(td).find('.noUi-target').eq(0);
+    var scale = Math.pow(10, Math.max(0, +slider.data('scale') || 0));
+    var new_vals = [props.params.min * scale, props.params.max * scale];
+
+    // Note what the new limits will be just for this filter
+    var new_lims = new_vals.slice();
+
+    // Determine the current values and limits
+    var old_vals = slider.val().map(Number);
+    var old_lims = slider.noUiSlider('options').range;
+    old_lims = [old_lims.min, old_lims.max];
+
+    // Preserve the current values if filters have been applied; otherwise, apply no filtering
+    if (old_vals[0] != old_lims[0]) {
+      new_vals[0] = Math.max(old_vals[0], new_vals[0]);
+    }
+
+    if (old_vals[1] != old_lims[1]) {
+      new_vals[1] = Math.min(old_vals[1], new_vals[1]);
+    }
+
+    // Update the endpoints of the slider
+    slider.noUiSlider({
+      start: new_vals,
+      range: {'min': new_lims[0], 'max': new_lims[1]}
+    }, true);
+  }
+};
+
+var transposeArray2D = function(a) {
+  return a.length === 0 ? a : HTMLWidgets.transposeArray2D(a);
+};
+
+var crosstalkPluginsInstalled = false;
+
+function maybeInstallCrosstalkPlugins() {
+  if (crosstalkPluginsInstalled)
+    return;
+  crosstalkPluginsInstalled = true;
+
+  $.fn.dataTable.ext.afnFiltering.push(
+    function(oSettings, aData, iDataIndex) {
+      var ctfilter = oSettings.nTable.ctfilter;
+      if (ctfilter && !ctfilter[iDataIndex])
+        return false;
+
+      var ctselect = oSettings.nTable.ctselect;
+      if (ctselect && !ctselect[iDataIndex])
+        return false;
+
+      return true;
+    }
+  );
+}
+
+HTMLWidgets.widget({
+  name: "datatables",
+  type: "output",
+  renderOnNullValue: true,
+  initialize: function(el, width, height) {
+    // in order that the type=number inputs return a number
+    $.valHooks.number = {
+      get: function(el) {
+        var value = parseFloat(el.value);
+        return isNaN(value) ? "" : value;
+      }
+    };
+    $(el).html('&nbsp;');
+    return {
+      data: null,
+      ctfilterHandle: new crosstalk.FilterHandle(),
+      ctfilterSubscription: null,
+      ctselectHandle: new crosstalk.SelectionHandle(),
+      ctselectSubscription: null
+    };
+  },
+  renderValue: function(el, data, instance) {
+    if (el.offsetWidth === 0 || el.offsetHeight === 0) {
+      instance.data = data;
+      return;
+    }
+    instance.data = null;
+    var $el = $(el);
+    $el.empty();
+
+    if (data === null) {
+      $el.append('&nbsp;');
+      // clear previous Shiny inputs (if any)
+      for (var i in instance.clearInputs) instance.clearInputs[i]();
+      instance.clearInputs = {};
+      return;
+    }
+
+    var crosstalkOptions = data.crosstalkOptions;
+    if (!crosstalkOptions) crosstalkOptions = {
+      'key': null, 'group': null
+    };
+    if (crosstalkOptions.group) {
+      maybeInstallCrosstalkPlugins();
+      instance.ctfilterHandle.setGroup(crosstalkOptions.group);
+      instance.ctselectHandle.setGroup(crosstalkOptions.group);
+    }
+
+    // if we are in the viewer then we always want to fillContainer and
+    // and autoHideNavigation (unless the user has explicitly set these)
+    if (window.HTMLWidgets.viewerMode) {
+      if (!data.hasOwnProperty("fillContainer"))
+        data.fillContainer = true;
+      if (!data.hasOwnProperty("autoHideNavigation"))
+        data.autoHideNavigation = true;
+    }
+
+    // propagate fillContainer to instance (so we have it in resize)
+    instance.fillContainer = data.fillContainer;
+
+    var cells = data.data;
+
+    if (cells instanceof Array) cells = transposeArray2D(cells);
+
+    $el.append(data.container);
+    var $table = $el.find('table');
+    if (data.class) $table.addClass(data.class);
+    if (data.caption) $table.prepend(data.caption);
+
+    if (!data.selection) data.selection = {
+      mode: 'none', selected: null, target: 'row', selectable: null
+    };
+    if (HTMLWidgets.shinyMode && data.selection.mode !== 'none' &&
+        data.selection.target === 'row+column') {
+      if ($table.children('tfoot').length === 0) {
+        $table.append($('<tfoot>'));
+        $table.find('thead tr').clone().appendTo($table.find('tfoot'));
+      }
+    }
+
+    // column filters
+    var filterRow;
+    switch (data.filter) {
+      case 'top':
+        $table.children('thead').append(data.filterHTML);
+        filterRow = $table.find('thead tr:last td');
+        break;
+      case 'bottom':
+        if ($table.children('tfoot').length === 0) {
+          $table.append($('<tfoot>'));
+        }
+        $table.children('tfoot').prepend(data.filterHTML);
+        filterRow = $table.find('tfoot tr:first td');
+        break;
+    }
+
+    var options = { searchDelay: 1000 };
+    if (cells !== null) $.extend(options, {
+      data: cells
+    });
+
+    // options for fillContainer
+    var bootstrapActive = typeof($.fn.popover) != 'undefined';
+    if (instance.fillContainer) {
+
+      // force scrollX/scrollY and turn off autoWidth
+      options.scrollX = true;
+      options.scrollY = "100px"; // can be any value, we'll adjust below
+
+      // if we aren't paginating then move around the info/filter controls
+      // to save space at the bottom and rephrase the info callback
+      if (data.options.paging === false) {
+
+        // we know how to do this cleanly for bootstrap, not so much
+        // for other themes/layouts
+        if (bootstrapActive) {
+          options.dom = "<'row'<'col-sm-4'i><'col-sm-8'f>>" +
+                        "<'row'<'col-sm-12'tr>>";
+        }
+
+        options.fnInfoCallback = function(oSettings, iStart, iEnd,
+                                           iMax, iTotal, sPre) {
+          return Number(iTotal).toLocaleString() + " records";
+        };
+      }
+    }
+
+    // auto hide navigation if requested
+    // Note, this only works on client-side processing mode as on server-side,
+    // cells (data.data) is null; In addition, we require the pageLength option
+    // being provided explicitly to enable this. Despite we may be able to deduce
+    // the default value of pageLength, it may complicate things so we'd rather
+    // put this responsiblity to users and warn them on the R side.
+    if (data.autoHideNavigation === true && data.options.paging !== false) {
+      // strip all nav if length >= cells
+      if ((cells instanceof Array) && data.options.pageLength >= cells.length)
+        options.dom = bootstrapActive ? "<'row'<'col-sm-12'tr>>" : "t";
+      // alternatively lean things out for flexdashboard mobile portrait
+      else if (bootstrapActive && window.FlexDashboard && window.FlexDashboard.isMobilePhone())
+        options.dom = "<'row'<'col-sm-12'f>>" +
+                      "<'row'<'col-sm-12'tr>>"  +
+                      "<'row'<'col-sm-12'p>>";
+    }
+
+    $.extend(true, options, data.options || {});
+
+    var searchCols = options.searchCols;
+    if (searchCols) {
+      searchCols = searchCols.map(function(x) {
+        return x === null ? '' : x.search;
+      });
+      // FIXME: this means I don't respect the escapeRegex setting
+      delete options.searchCols;
+    }
+
+    // server-side processing?
+    var server = options.serverSide === true;
+
+    // use the dataSrc function to pre-process JSON data returned from R
+    var DT_rows_all = [], DT_rows_current = [];
+    if (server && HTMLWidgets.shinyMode && typeof options.ajax === 'object' &&
+        /^session\/[\da-z]+\/dataobj/.test(options.ajax.url) && !options.ajax.dataSrc) {
+      options.ajax.dataSrc = function(json) {
+        DT_rows_all = $.makeArray(json.DT_rows_all);
+        DT_rows_current = $.makeArray(json.DT_rows_current);
+        var data = json.data;
+        if (!colReorderEnabled()) return data;
+        var table = $table.DataTable(), order = table.colReorder.order(), flag = true, i, j, row;
+        for (i = 0; i < order.length; ++i) if (order[i] !== i) flag = false;
+        if (flag) return data;
+        for (i = 0; i < data.length; ++i) {
+          row = data[i].slice();
+          for (j = 0; j < order.length; ++j) data[i][j] = row[order[j]];
+        }
+        return data;
+      };
+    }
+
+    var thiz = this;
+    if (instance.fillContainer) $table.on('init.dt', function(e) {
+      thiz.fillAvailableHeight(el, $(el).innerHeight());
+    });
+    // If the page contains serveral datatables and one of which enables colReorder,
+    // the table.colReorder.order() function will exist but throws error when called.
+    // So it seems like the only way to know if colReorder is enabled or not is to
+    // check the options.
+    var colReorderEnabled = function() { return "colReorder" in options; };
+    var table = $table.DataTable(options);
+    $el.data('datatable', table);
+
+    if ('rowGroup' in options) {
+      // Maintain RowGroup dataSrc when columns are reordered (#1109)
+      table.on('column-reorder', function(e, settings, details) {
+        var oldDataSrc = table.rowGroup().dataSrc();
+        var newDataSrc = details.mapping[oldDataSrc];
+        table.rowGroup().dataSrc(newDataSrc);
+      });
+    }
+
+    // Unregister previous Crosstalk event subscriptions, if they exist
+    if (instance.ctfilterSubscription) {
+      instance.ctfilterHandle.off("change", instance.ctfilterSubscription);
+      instance.ctfilterSubscription = null;
+    }
+    if (instance.ctselectSubscription) {
+      instance.ctselectHandle.off("change", instance.ctselectSubscription);
+      instance.ctselectSubscription = null;
+    }
+
+    if (!crosstalkOptions.group) {
+      $table[0].ctfilter = null;
+      $table[0].ctselect = null;
+    } else {
+      var key = crosstalkOptions.key;
+      function keysToMatches(keys) {
+        if (!keys) {
+          return null;
+        } else {
+          var selectedKeys = {};
+          for (var i = 0; i < keys.length; i++) {
+            selectedKeys[keys[i]] = true;
+          }
+          var matches = {};
+          for (var j = 0; j < key.length; j++) {
+            if (selectedKeys[key[j]])
+              matches[j] = true;
+          }
+          return matches;
+        }
+      }
+
+      function applyCrosstalkFilter(e) {
+        $table[0].ctfilter = keysToMatches(e.value);
+        table.draw();
+      }
+      instance.ctfilterSubscription = instance.ctfilterHandle.on("change", applyCrosstalkFilter);
+      applyCrosstalkFilter({value: instance.ctfilterHandle.filteredKeys});
+
+      function applyCrosstalkSelection(e) {
+        if (e.sender !== instance.ctselectHandle) {
+          table
+            .rows('.' + selClass, {search: 'applied'})
+            .nodes()
+            .to$()
+            .removeClass(selClass);
+          if (selectedRows)
+            changeInput('rows_selected', selectedRows(), void 0, true);
+        }
+
+        if (e.sender !== instance.ctselectHandle && e.value && e.value.length) {
+          var matches = keysToMatches(e.value);
+
+          // persistent selection with plotly (& leaflet)
+          var ctOpts = crosstalk.var("plotlyCrosstalkOpts").get() || {};
+          if (ctOpts.persistent === true) {
+            var matches = $.extend(matches, $table[0].ctselect);
+          }
+
+          $table[0].ctselect = matches;
+          table.draw();
+        } else {
+          if ($table[0].ctselect) {
+            $table[0].ctselect = null;
+            table.draw();
+          }
+        }
+      }
+      instance.ctselectSubscription = instance.ctselectHandle.on("change", applyCrosstalkSelection);
+      // TODO: This next line doesn't seem to work when renderDataTable is used
+      applyCrosstalkSelection({value: instance.ctselectHandle.value});
+    }
+
+    var inArray = function(val, array) {
+      return $.inArray(val, $.makeArray(array)) > -1;
+    };
+
+    // search the i-th column
+    var searchColumn = function(i, value) {
+      var regex = false, ci = true;
+      if (options.search) {
+        regex = options.search.regex,
+        ci = options.search.caseInsensitive !== false;
+      }
+      // need to transpose the column index when colReorder is enabled
+      if (table.colReorder) i = table.colReorder.transpose(i);
+      return table.column(i).search(value, regex, !regex, ci);
+    };
+
+    if (data.filter !== 'none') {
+      if (!data.hasOwnProperty('filterSettings')) data.filterSettings = {};
+
+      filterRow.each(function(i, td) {
+
+        var $td = $(td), type = $td.data('type'), filter;
+        var $input = $td.children('div').first().children('input');
+        var disabled = $input.prop('disabled');
+        var searchable = table.settings()[0].aoColumns[i].bSearchable;
+        $input.prop('disabled', !searchable || disabled);
+        $input.data('searchable', searchable); // for updating later
+        $input.on('input blur', function() {
+          $input.next('span').toggle(Boolean($input.val()));
+        });
+        // Bootstrap sets pointer-events to none and we won't be able to click
+        // the clear button
+        $input.next('span').css('pointer-events', 'auto').hide().click(function() {
+          $(this).hide().prev('input').val('').trigger('input').focus();
+        });
+        var searchCol;  // search string for this column
+        if (searchCols && searchCols[i]) {
+          searchCol = searchCols[i];
+          $input.val(searchCol).trigger('input');
+        }
+        var $x = $td.children('div').last();
+
+        // remove the overflow: hidden attribute of the scrollHead
+        // (otherwise the scrolling table body obscures the filters)
+        // The workaround and the discussion from
+        // https://github.com/rstudio/DT/issues/554#issuecomment-518007347
+        // Otherwise the filter selection will not be anchored to the values
+        // when the columns number is many and scrollX is enabled.
+        var scrollHead = $(el).find('.dataTables_scrollHead,.dataTables_scrollFoot');
+        var cssOverflowHead = scrollHead.css('overflow');
+        var scrollBody = $(el).find('.dataTables_scrollBody');
+        var cssOverflowBody = scrollBody.css('overflow');
+        var scrollTable = $(el).find('.dataTables_scroll');
+        var cssOverflowTable = scrollTable.css('overflow');
+        if (cssOverflowHead === 'hidden') {
+          $x.on('show hide', function(e) {
+            if (e.type === 'show') {
+              scrollHead.css('overflow', 'visible');
+              scrollBody.css('overflow', 'visible');
+              scrollTable.css('overflow-x', 'scroll');
+            } else {
+              scrollHead.css('overflow', cssOverflowHead);
+              scrollBody.css('overflow', cssOverflowBody);
+              scrollTable.css('overflow-x', cssOverflowTable);
+            }
+          });
+          $x.css('z-index', 25);
+        }
+
+        if (inArray(type, ['factor', 'logical'])) {
+          $input.on({
+            click: function() {
+              $input.parent().hide(); $x.show().trigger('show'); filter[0].selectize.focus();
+            },
+            input: function() {
+              var v1 = JSON.stringify(filter[0].selectize.getValue()), v2 = $input.val();
+              if (v1 === '[]') v1 = '';
+              if (v1 !== v2) filter[0].selectize.setValue(v2 === '' ? [] : JSON.parse(v2));
+            }
+          });
+          var $input2 = $x.children('select');
+          filter = $input2.selectize($.extend({
+            options: $input2.data('options').map(function(v, i) {
+              return ({text: v, value: v});
+            }),
+            plugins: ['remove_button'],
+            hideSelected: true,
+            onChange: function(value) {
+              if (value === null) value = []; // compatibility with jQuery 3.0
+              $input.val(value.length ? JSON.stringify(value) : '');
+              if (value.length) $input.trigger('input');
+              $input.attr('title', $input.val());
+              if (server) {
+                searchColumn(i, value.length ? JSON.stringify(value) : '').draw();
+                return;
+              }
+              // turn off filter if nothing selected
+              $td.data('filter', value.length > 0);
+              table.draw();  // redraw table, and filters will be applied
+            }
+          }, data.filterSettings.select));
+          filter[0].selectize.on('blur', function() {
+            $x.hide().trigger('hide'); $input.parent().show(); $input.trigger('blur');
+          });
+          filter.next('div').css('margin-bottom', 'auto');
+        } else if (type === 'character') {
+          var fun = function() {
+            searchColumn(i, $input.val()).draw();
+          };
+          // throttle searching for server-side processing
+          var throttledFun = $.fn.dataTable.util.throttle(fun, options.searchDelay);
+          $input.on('input', function(e, immediate) {
+            // always bypass throttling when immediate = true (via the updateSearch method)
+            (immediate || !server) ? fun() : throttledFun();
+          });
+        } else if (inArray(type, ['number', 'integer', 'date', 'time'])) {
+          var $x0 = $x;
+          $x = $x0.children('div').first();
+          $x0.css({
+            'background-color': '#fff',
+            'border': '1px #ddd solid',
+            'border-radius': '4px',
+            'padding': data.vertical ? '35px 20px': '20px 20px 10px 20px'
+          });
+          var $spans = $x0.children('span').css({
+            'margin-top': data.vertical ? '0' : '10px',
+            'white-space': 'nowrap'
+          });
+          var $span1 = $spans.first(), $span2 = $spans.last();
+          var r1 = +$x.data('min'), r2 = +$x.data('max');
+          // when the numbers are too small or have many decimal places, the
+          // slider may have numeric precision problems (#150)
+          var scale = Math.pow(10, Math.max(0, +$x.data('scale') || 0));
+          r1 = Math.round(r1 * scale); r2 = Math.round(r2 * scale);
+          var scaleBack = function(x, scale) {
+            if (scale === 1) return x;
+            var d = Math.round(Math.log(scale) / Math.log(10));
+            // to avoid problems like 3.423/100 -> 0.034230000000000003
+            return (x / scale).toFixed(d);
+          };
+          var slider_min = function() {
+            return filter.noUiSlider('options').range.min;
+          };
+          var slider_max = function() {
+            return filter.noUiSlider('options').range.max;
+          };
+          $input.on({
+            focus: function() {
+              $x0.show().trigger('show');
+              // first, make sure the slider div leaves at least 20px between
+              // the two (slider value) span's
+              $x0.width(Math.max(160, $span1.outerWidth() + $span2.outerWidth() + 20));
+              // then, if the input is really wide or slider is vertical,
+              // make the slider the same width as the input
+              if ($x0.outerWidth() < $input.outerWidth() || data.vertical) {
+                $x0.outerWidth($input.outerWidth());
+              }
+              // make sure the slider div does not reach beyond the right margin
+              if ($(window).width() < $x0.offset().left + $x0.width()) {
+                $x0.offset({
+                  'left': $input.offset().left + $input.outerWidth() - $x0.outerWidth()
+                });
+              }
+            },
+            blur: function() {
+              $x0.hide().trigger('hide');
+            },
+            input: function() {
+              if ($input.val() === '') filter.val([slider_min(), slider_max()]);
+            },
+            change: function() {
+              var v = $input.val().replace(/\s/g, '');
+              if (v === '') return;
+              v = v.split('...');
+              if (v.length !== 2) {
+                $input.parent().addClass('has-error');
+                return;
+              }
+              if (v[0] === '') v[0] = slider_min();
+              if (v[1] === '') v[1] = slider_max();
+              $input.parent().removeClass('has-error');
+              // treat date as UTC time at midnight
+              var strTime = function(x) {
+                var s = type === 'date' ? 'T00:00:00Z' : '';
+                var t = new Date(x + s).getTime();
+                // add 10 minutes to date since it does not hurt the date, and
+                // it helps avoid the tricky floating point arithmetic problems,
+                // e.g. sometimes the date may be a few milliseconds earlier
+                // than the midnight due to precision problems in noUiSlider
+                return type === 'date' ? t + 3600000 : t;
+              };
+              if (inArray(type, ['date', 'time'])) {
+                v[0] = strTime(v[0]);
+                v[1] = strTime(v[1]);
+              }
+              if (v[0] != slider_min()) v[0] *= scale;
+              if (v[1] != slider_max()) v[1] *= scale;
+              filter.val(v);
+            }
+          });
+          var formatDate = function(d) {
+            d = scaleBack(d, scale);
+            if (type === 'number') return d;
+            if (type === 'integer') return parseInt(d);
+            var x = new Date(+d);
+            if (type === 'date') {
+              var pad0 = function(x) {
+                return ('0' + x).substr(-2, 2);
+              };
+              return x.getUTCFullYear() + '-' + pad0(1 + x.getUTCMonth())
+                      + '-' + pad0(x.getUTCDate());
+            } else {
+              return x.toISOString();
+            }
+          };
+          var opts = type === 'date' ? { step: 60 * 60 * 1000 } :
+                     type === 'integer' ? { step: 1 } : {};
+
+          opts.orientation = data.vertical ? 'vertical': 'horizontal';
+          opts.direction = data.vertical ? 'rtl': 'ltr';
+
+          filter = $x.noUiSlider($.extend({
+            start: [r1, r2],
+            range: {min: r1, max: r2},
+            connect: true
+          }, opts, data.filterSettings.slider));
+          if (scale > 1) (function() {
+            var t1 = r1, t2 = r2;
+            var val = filter.val();
+            while (val[0] > r1 || val[1] < r2) {
+              if (val[0] > r1) {
+                t1 -= val[0] - r1;
+              }
+              if (val[1] < r2) {
+                t2 += r2 - val[1];
+              }
+              filter = $x.noUiSlider($.extend({
+                start: [t1, t2],
+                range: {min: t1, max: t2},
+                connect: true
+              }, opts, data.filterSettings.slider), true);
+              val = filter.val();
+            }
+            r1  = t1; r2 = t2;
+          })();
+          // format with active column renderer, if defined
+          var colDef = data.options.columnDefs.find(function(def) {
+            return (def.targets === i || inArray(i, def.targets)) && 'render' in def;
+          });
+          var updateSliderText = function(v1, v2) {
+            // we only know how to use function renderers
+            if (colDef && typeof colDef.render === 'function') {
+              var restore = function(v) {
+                v = scaleBack(v, scale);
+                return inArray(type, ['date', 'time']) ? new Date(+v) : v;
+              }
+              $span1.text(colDef.render(restore(v1), 'display'));
+              $span2.text(colDef.render(restore(v2), 'display'));
+            } else {
+              $span1.text(formatDate(v1));
+              $span2.text(formatDate(v2));
+            }
+          };
+          updateSliderText(r1, r2);
+          var updateSlider = function(e) {
+            var val = filter.val();
+            // turn off filter if in full range
+            $td.data('filter', val[0] > slider_min() || val[1] < slider_max());
+            var v1 = formatDate(val[0]), v2 = formatDate(val[1]), ival;
+            if ($td.data('filter')) {
+              ival = v1 + ' ... ' + v2;
+              $input.attr('title', ival).val(ival).trigger('input');
+            } else {
+              $input.attr('title', '').val('');
+            }
+            updateSliderText(val[0], val[1]);
+            if (e.type === 'slide') return;  // no searching when sliding only
+            if (server) {
+              searchColumn(i, $td.data('filter') ? ival : '').draw();
+              return;
+            }
+            table.draw();
+          };
+          filter.on({
+            set: updateSlider,
+            slide: updateSlider
+          });
+        }
+
+        // server-side processing will be handled by R (or whatever server
+        // language you use); the following code is only needed for client-side
+        // processing
+        if (server) {
+          // if a search string has been pre-set, search now
+          if (searchCol) $input.trigger('input').trigger('change');
+          return;
+        }
+
+        var customFilter = function(settings, data, dataIndex) {
+          // there is no way to attach a search function to a specific table,
+          // and we need to make sure a global search function is not applied to
+          // all tables (i.e. a range filter in a previous table should not be
+          // applied to the current table); we use the settings object to
+          // determine if we want to perform searching on the current table,
+          // since settings.sTableId will be different to different tables
+          if (table.settings()[0] !== settings) return true;
+          // no filter on this column or no need to filter this column
+          if (typeof filter === 'undefined' || !$td.data('filter')) return true;
+
+          var r = filter.val(), v, r0, r1;
+          var i_data = function(i) {
+            if (!colReorderEnabled()) return i;
+            var order = table.colReorder.order(), k;
+            for (k = 0; k < order.length; ++k) if (order[k] === i) return k;
+            return i; // in theory it will never be here...
+          }
+          v = data[i_data(i)];
+          if (type === 'number' || type === 'integer') {
+            v = parseFloat(v);
+            // how to handle NaN? currently exclude these rows
+            if (isNaN(v)) return(false);
+            r0 = parseFloat(scaleBack(r[0], scale))
+            r1 = parseFloat(scaleBack(r[1], scale));
+            if (v >= r0 && v <= r1) return true;
+          } else if (type === 'date' || type === 'time') {
+            v = new Date(v);
+            r0 = new Date(r[0] / scale); r1 = new Date(r[1] / scale);
+            if (v >= r0 && v <= r1) return true;
+          } else if (type === 'factor') {
+            if (r.length === 0 || inArray(v, r)) return true;
+          } else if (type === 'logical') {
+            if (r.length === 0) return true;
+            if (inArray(v === '' ? 'na' : v, r)) return true;
+          }
+          return false;
+        };
+
+        $.fn.dataTable.ext.search.push(customFilter);
+
+        // search for the preset search strings if it is non-empty
+        if (searchCol) $input.trigger('input').trigger('change');
+
+      });
+
+    }
+
+    // highlight search keywords
+    var highlight = function() {
+      var body = $(table.table().body());
+      // removing the old highlighting first
+      body.unhighlight();
+
+      // don't highlight the "not found" row, so we get the rows using the api
+      if (table.rows({ filter: 'applied' }).data().length === 0) return;
+      // highlight global search keywords
+      body.highlight($.trim(table.search()).split(/\s+/));
+      // then highlight keywords from individual column filters
+      if (filterRow) filterRow.each(function(i, td) {
+        var $td = $(td), type = $td.data('type');
+        if (type !== 'character') return;
+        var $input = $td.children('div').first().children('input');
+        var column = table.column(i).nodes().to$(),
+            val = $.trim($input.val());
+        if (type !== 'character' || val === '') return;
+        column.highlight(val.split(/\s+/));
+      });
+    };
+
+    if (options.searchHighlight) {
+      table
+      .on('draw.dt.dth column-visibility.dt.dth column-reorder.dt.dth', highlight)
+      .on('destroy', function() {
+        // remove event handler
+        table.off('draw.dt.dth column-visibility.dt.dth column-reorder.dt.dth');
+      });
+
+      // Set the option for escaping regex characters in our search string.  This will be used
+      // for all future matching.
+      jQuery.fn.highlight.options.escapeRegex = (!options.search || !options.search.regex);
+
+      // initial highlight for state saved conditions and initial states
+      highlight();
+    }
+
+    // run the callback function on the table instance
+    if (typeof data.callback === 'function') data.callback(table);
+
+    // double click to edit the cell, row, column, or all cells
+    if (data.editable) table.on('dblclick.dt', 'tbody td', function(e) {
+      // only bring up the editor when the cell itself is dbclicked, and ignore
+      // other dbclick events bubbled up (e.g. from the <input>)
+      if (e.target !== this) return;
+      var target = [], immediate = false;
+      switch (data.editable.target) {
+        case 'cell':
+          target = [this];
+          immediate = true;  // edit will take effect immediately
+          break;
+        case 'row':
+          target = table.cells(table.cell(this).index().row, '*').nodes();
+          break;
+        case 'column':
+          target = table.cells('*', table.cell(this).index().column).nodes();
+          break;
+        case 'all':
+          target = table.cells().nodes();
+          break;
+        default:
+          throw 'The editable parameter must be "cell", "row", "column", or "all"';
+      }
+      var disableCols = data.editable.disable ? data.editable.disable.columns : null;
+      var numericCols = data.editable.numeric;
+      var areaCols = data.editable.area;
+      var dateCols = data.editable.date;
+      for (var i = 0; i < target.length; i++) {
+        (function(cell, current) {
+          var $cell = $(cell), html = $cell.html();
+          var _cell = table.cell(cell), value = _cell.data(), index = _cell.index().column;
+          var $input;
+          if (inArray(index, numericCols)) {
+            $input = $('<input type="number">');
+          } else if (inArray(index, areaCols)) {
+            $input = $('<textarea></textarea>');
+          } else if (inArray(index, dateCols)) {
+            $input = $('<input type="date">');
+          } else {
+            $input = $('<input type="text">');
+          }
+          if (!immediate) {
+            $cell.data('input', $input).data('html', html);
+            $input.attr('title', 'Hit Ctrl+Enter to finish editing, or Esc to cancel');
+          }
+          $input.val(value);
+          if (inArray(index, disableCols)) {
+            $input.attr('readonly', '').css('filter', 'invert(25%)');
+          }
+          $cell.empty().append($input);
+          if (cell === current) $input.focus();
+          $input.css('width', '100%');
+
+          if (immediate) $input.on('blur', function(e) {
+            var valueNew = $input.val();
+            if (valueNew !== value) {
+              _cell.data(valueNew);
+              if (HTMLWidgets.shinyMode) {
+                changeInput('cell_edit', [cellInfo(cell)], 'DT.cellInfo', null, {priority: 'event'});
+              }
+              // for server-side processing, users have to call replaceData() to update the table
+              if (!server) table.draw(false);
+            } else {
+              $cell.html(html);
+            }
+          }).on('keyup', function(e) {
+            // hit Escape to cancel editing
+            if (e.keyCode === 27) $input.trigger('blur');
+          });
+
+          // bulk edit (row, column, or all)
+          if (!immediate) $input.on('keyup', function(e) {
+            var removeInput = function($cell, restore) {
+              $cell.data('input').remove();
+              if (restore) $cell.html($cell.data('html'));
+            }
+            if (e.keyCode === 27) {
+              for (var i = 0; i < target.length; i++) {
+                removeInput($(target[i]), true);
+              }
+            } else if (e.keyCode === 13 && e.ctrlKey) {
+              // Ctrl + Enter
+              var cell, $cell, _cell, cellData = [];
+              for (var i = 0; i < target.length; i++) {
+                cell = target[i]; $cell = $(cell); _cell = table.cell(cell);
+                _cell.data($cell.data('input').val());
+                HTMLWidgets.shinyMode && cellData.push(cellInfo(cell));
+                removeInput($cell, false);
+              }
+              if (HTMLWidgets.shinyMode) {
+                changeInput('cell_edit', cellData, 'DT.cellInfo', null, {priority: "event"});
+              }
+              if (!server) table.draw(false);
+            }
+          });
+        })(target[i], this);
+      }
+    });
+
+    // interaction with shiny
+    if (!HTMLWidgets.shinyMode && !crosstalkOptions.group) return;
+
+    var methods = {};
+    var shinyData = {};
+
+    methods.updateCaption = function(caption) {
+      if (!caption) return;
+      $table.children('caption').replaceWith(caption);
+    }
+
+    // register clear functions to remove input values when the table is removed
+    instance.clearInputs = {};
+
+    var changeInput = function(id, value, type, noCrosstalk, opts) {
+      var event = id;
+      id = el.id + '_' + id;
+      if (type) id = id + ':' + type;
+      // do not update if the new value is the same as old value
+      if (event !== 'cell_edit' && !/_clicked$/.test(event) && shinyData.hasOwnProperty(id) && shinyData[id] === JSON.stringify(value))
+        return;
+      shinyData[id] = JSON.stringify(value);
+      if (HTMLWidgets.shinyMode && Shiny.setInputValue) {
+        Shiny.setInputValue(id, value, opts);
+        if (!instance.clearInputs[id]) instance.clearInputs[id] = function() {
+          Shiny.setInputValue(id, null);
+        }
+      }
+
+      // HACK
+      if (event === "rows_selected" && !noCrosstalk) {
+        if (crosstalkOptions.group) {
+          var keys = crosstalkOptions.key;
+          var selectedKeys = null;
+          if (value) {
+            selectedKeys = [];
+            for (var i = 0; i < value.length; i++) {
+              // The value array's contents use 1-based row numbers, so we must
+              // convert to 0-based before indexing into the keys array.
+              selectedKeys.push(keys[value[i] - 1]);
+            }
+          }
+          instance.ctselectHandle.set(selectedKeys);
+        }
+      }
+    };
+
+    var addOne = function(x) {
+      return x.map(function(i) { return 1 + i; });
+    };
+
+    var unique = function(x) {
+      var ux = [];
+      $.each(x, function(i, el){
+        if ($.inArray(el, ux) === -1) ux.push(el);
+      });
+      return ux;
+    }
+
+    // change the row index of a cell
+    var tweakCellIndex = function(cell) {
+      var info = cell.index();
+      // some cell may not be valid. e.g, #759
+      // when using the RowGroup extension, datatables will
+      // generate the row label and the cells are not part of
+      // the data thus contain no row/col info
+      if (info === undefined)
+        return {row: null, col: null};
+      if (server) {
+        info.row = DT_rows_current[info.row];
+      } else {
+        info.row += 1;
+      }
+      return {row: info.row, col: info.column};
+    }
+
+    var cleanSelectedValues = function() {
+      changeInput('rows_selected', []);
+      changeInput('columns_selected', []);
+      changeInput('cells_selected', transposeArray2D([]), 'shiny.matrix');
+    }
+    // #828 we should clean the selection on the server-side when the table reloads
+    cleanSelectedValues();
+
+    // a flag to indicates if select extension is initialized or not
+    var flagSelectExt = table.settings()[0]._select !== undefined;
+    // the Select extension should only be used in the client mode and
+    // when the selection.mode is set to none
+    if (data.selection.mode === 'none' && !server && flagSelectExt) {
+      var updateRowsSelected = function() {
+        var rows = table.rows({selected: true});
+        var selected = [];
+        $.each(rows.indexes().toArray(), function(i, v) {
+          selected.push(v + 1);
+        });
+        changeInput('rows_selected', selected);
+      }
+      var updateColsSelected = function() {
+        var columns = table.columns({selected: true});
+        changeInput('columns_selected', columns.indexes().toArray());
+      }
+      var updateCellsSelected = function() {
+        var cells = table.cells({selected: true});
+        var selected = [];
+        cells.every(function() {
+          var row = this.index().row;
+          var col = this.index().column;
+          selected = selected.concat([[row + 1, col]]);
+        });
+        changeInput('cells_selected', transposeArray2D(selected), 'shiny.matrix');
+      }
+      table.on('select deselect', function(e, dt, type, indexes) {
+        updateRowsSelected();
+        updateColsSelected();
+        updateCellsSelected();
+      })
+      updateRowsSelected();
+      updateColsSelected();
+      updateCellsSelected();
+    }
+
+    var selMode = data.selection.mode, selTarget = data.selection.target;
+    var selDisable = data.selection.selectable === false;
+    if (inArray(selMode, ['single', 'multiple'])) {
+      var selClass = inArray(data.style, ['bootstrap', 'bootstrap4']) ? 'active' : 'selected';
+      // selected1: row indices; selected2: column indices
+      var initSel = function(x) {
+        if (x === null || typeof x === 'boolean' || selTarget === 'cell') {
+          return {rows: [], cols: []};
+        } else if (selTarget === 'row') {
+          return {rows: $.makeArray(x), cols: []};
+        } else if (selTarget === 'column') {
+          return {rows: [], cols: $.makeArray(x)};
+        } else if (selTarget === 'row+column') {
+          return {rows: $.makeArray(x.rows), cols: $.makeArray(x.cols)};
+        }
+      }
+      var selected = data.selection.selected;
+      var selected1 = initSel(selected).rows, selected2 = initSel(selected).cols;
+      // selectable should contain either all positive or all non-positive values, not both
+      // positive values indicate "selectable" while non-positive values means "nonselectable"
+      // the assertion is performed on R side. (only column indicides could be zero which indicates
+      // the row name)
+      var selectable = data.selection.selectable;
+      var selectable1 = initSel(selectable).rows, selectable2 = initSel(selectable).cols;
+
+      // After users reorder the rows or filter the table, we cannot use the table index
+      // directly. Instead, we need this function to find out the rows between the two clicks.
+      // If user filter the table again between the start click and the end click, the behavior
+      // would be undefined, but it should not be a problem.
+      var shiftSelRowsIndex = function(start, end) {
+        var indexes = server ? DT_rows_all : table.rows({ search: 'applied' }).indexes().toArray();
+        start = indexes.indexOf(start); end = indexes.indexOf(end);
+        // if start is larger than end, we need to swap
+        if (start > end) {
+          var tmp = end; end = start; start = tmp;
+        }
+        return indexes.slice(start, end + 1);
+      }
+
+      var serverRowIndex = function(clientRowIndex) {
+        return server ? DT_rows_current[clientRowIndex] : clientRowIndex + 1;
+      }
+
+      // row, column, or cell selection
+      var lastClickedRow;
+      if (inArray(selTarget, ['row', 'row+column'])) {
+        // Get the current selected rows. It will also
+        // update the selected1's value based on the current row selection state
+        // Note we can't put this function inside selectRows() directly,
+        // the reason is method.selectRows() will override selected1's value but this
+        // function will add rows to selected1 (keep the existing selection), which is
+        // inconsistent with column and cell selection.
+        var selectedRows = function() {
+          var rows = table.rows('.' + selClass);
+          var idx = rows.indexes().toArray();
+          if (!server) {
+            selected1 = addOne(idx);
+            return selected1;
+          }
+          idx = idx.map(function(i) {
+            return DT_rows_current[i];
+          });
+          selected1 = selMode === 'multiple' ? unique(selected1.concat(idx)) : idx;
+          return selected1;
+        }
+        // Change selected1's value based on selectable1, then refresh the row state
+        var onlyKeepSelectableRows = function() {
+          if (selDisable) { // users can't select; useful when only want backend select
+            selected1 = [];
+            return;
+          }
+          if (selectable1.length === 0) return;
+          var nonselectable = selectable1[0] <= 0;
+          if (nonselectable) {
+            // should make selectable1 positive
+            selected1 = $(selected1).not(selectable1.map(function(i) { return -i; })).get();
+          } else {
+            selected1 = $(selected1).filter(selectable1).get();
+          }
+        }
+        // Change selected1's value based on selectable1, then
+        // refresh the row selection state according to values in selected1
+        var selectRows = function(ignoreSelectable) {
+          if (!ignoreSelectable) onlyKeepSelectableRows();
+          table.$('tr.' + selClass).removeClass(selClass);
+          if (selected1.length === 0) return;
+          if (server) {
+            table.rows({page: 'current'}).every(function() {
+              if (inArray(DT_rows_current[this.index()], selected1)) {
+                $(this.node()).addClass(selClass);
+              }
+            });
+          } else {
+            var selected0 = selected1.map(function(i) { return i - 1; });
+            $(table.rows(selected0).nodes()).addClass(selClass);
+          }
+        }
+        table.on('mousedown.dt', 'tbody tr', function(e) {
+          var $this = $(this), thisRow = table.row(this);
+          if (selMode === 'multiple') {
+            if (e.shiftKey && lastClickedRow !== undefined) {
+              // select or de-select depends on the last clicked row's status
+              var flagSel = !$this.hasClass(selClass);
+              var crtClickedRow = serverRowIndex(thisRow.index());
+              if (server) {
+                var rowsIndex = shiftSelRowsIndex(lastClickedRow, crtClickedRow);
+                // update current page's selClass
+                rowsIndex.map(function(i) {
+                  var rowIndex = DT_rows_current.indexOf(i);
+                  if (rowIndex >= 0) {
+                    var row = table.row(rowIndex).nodes().to$();
+                    var flagRowSel = !row.hasClass(selClass);
+                    if (flagSel === flagRowSel) row.toggleClass(selClass);
+                  }
+                });
+                // update selected1
+                if (flagSel) {
+                  selected1 = unique(selected1.concat(rowsIndex));
+                } else {
+                  selected1 = selected1.filter(function(index) {
+                    return !inArray(index, rowsIndex);
+                  });
+                }
+              } else {
+                // js starts from 0
+                shiftSelRowsIndex(lastClickedRow - 1, crtClickedRow - 1).map(function(value) {
+                  var row = table.row(value).nodes().to$();
+                  var flagRowSel = !row.hasClass(selClass);
+                  if (flagSel === flagRowSel) row.toggleClass(selClass);
+                });
+              }
+              e.preventDefault();
+            } else {
+              $this.toggleClass(selClass);
+            }
+          } else {
+            if ($this.hasClass(selClass)) {
+              $this.removeClass(selClass);
+            } else {
+              table.$('tr.' + selClass).removeClass(selClass);
+              $this.addClass(selClass);
+            }
+          }
+          if (server && !$this.hasClass(selClass)) {
+            var id = DT_rows_current[thisRow.index()];
+            // remove id from selected1 since its class .selected has been removed
+            if (inArray(id, selected1)) selected1.splice($.inArray(id, selected1), 1);
+          }
+          selectedRows(); // update selected1's value based on selClass
+          selectRows(false); // only keep the selectable rows
+          changeInput('rows_selected', selected1);
+          changeInput('row_last_clicked', serverRowIndex(thisRow.index()), null, null, {priority: 'event'});
+          lastClickedRow = serverRowIndex(thisRow.index());
+        });
+        selectRows(false);  // in case users have specified pre-selected rows
+        // restore selected rows after the table is redrawn (e.g. sort/search/page);
+        // client-side tables will preserve the selections automatically; for
+        // server-side tables, we have to *real* row indices are in `selected1`
+        changeInput('rows_selected', selected1);
+        if (server) table.on('draw.dt', function(e) { selectRows(false); });
+        methods.selectRows = function(selected, ignoreSelectable) {
+          selected1 = $.makeArray(selected);
+          selectRows(ignoreSelectable);
+          changeInput('rows_selected', selected1);
+        }
+      }
+
+      if (inArray(selTarget, ['column', 'row+column'])) {
+        if (selTarget === 'row+column') {
+          $(table.columns().footer()).css('cursor', 'pointer');
+        }
+        // update selected2's value based on selectable2
+        var onlyKeepSelectableCols = function() {
+          if (selDisable) { // users can't select; useful when only want backend select
+            selected2 = [];
+            return;
+          }
+          if (selectable2.length === 0) return;
+          var nonselectable = selectable2[0] <= 0;
+          if (nonselectable) {
+            // need to make selectable2 positive
+            selected2 = $(selected2).not(selectable2.map(function(i) { return -i; })).get();
+          } else {
+            selected2 = $(selected2).filter(selectable2).get();
+          }
+        }
+        // update selected2 and then
+        // refresh the col selection state according to values in selected2
+        var selectCols = function(ignoreSelectable) {
+          if (!ignoreSelectable) onlyKeepSelectableCols();
+          // if selected2 is not a valide index (e.g., larger than the column number)
+          // table.columns(selected2) will fail and result in a blank table
+          // this is different from the table.rows(), where the out-of-range indexes
+          // doesn't affect at all
+          selected2 = $(selected2).filter(table.columns().indexes()).get();
+          table.columns().nodes().flatten().to$().removeClass(selClass);
+          if (selected2.length > 0)
+            table.columns(selected2).nodes().flatten().to$().addClass(selClass);
+        }
+        var callback = function() {
+          var colIdx = selTarget === 'column' ? table.cell(this).index().column :
+              $.inArray(this, table.columns().footer()),
+              thisCol = $(table.column(colIdx).nodes());
+          if (colIdx === -1) return;
+          if (thisCol.hasClass(selClass)) {
+            thisCol.removeClass(selClass);
+            selected2.splice($.inArray(colIdx, selected2), 1);
+          } else {
+            if (selMode === 'single') $(table.cells().nodes()).removeClass(selClass);
+            thisCol.addClass(selClass);
+            selected2 = selMode === 'single' ? [colIdx] : unique(selected2.concat([colIdx]));
+          }
+          selectCols(false); // update selected2 based on selectable
+          changeInput('columns_selected', selected2);
+        }
+        if (selTarget === 'column') {
+          $(table.table().body()).on('click.dt', 'td', callback);
+        } else {
+          $(table.table().footer()).on('click.dt', 'tr th', callback);
+        }
+        selectCols(false);  // in case users have specified pre-selected columns
+        changeInput('columns_selected', selected2);
+        if (server) table.on('draw.dt', function(e) { selectCols(false); });
+        methods.selectColumns = function(selected, ignoreSelectable) {
+          selected2 = $.makeArray(selected);
+          selectCols(ignoreSelectable);
+          changeInput('columns_selected', selected2);
+        }
+      }
+
+      if (selTarget === 'cell') {
+        var selected3 = [], selectable3 = [];
+        if (selected !== null) selected3 = selected;
+        if (selectable !== null && typeof selectable !== 'boolean') selectable3 = selectable;
+        var findIndex = function(ij, sel) {
+          for (var i = 0; i < sel.length; i++) {
+            if (ij[0] === sel[i][0] && ij[1] === sel[i][1]) return i;
+          }
+          return -1;
+        }
+         // Change selected3's value based on selectable3, then refresh the cell state
+        var onlyKeepSelectableCells = function() {
+          if (selDisable) { // users can't select; useful when only want backend select
+            selected3 = [];
+            return;
+          }
+          if (selectable3.length === 0) return;
+          var nonselectable = selectable3[0][0] <= 0;
+          var out = [];
+          if (nonselectable) {
+            selected3.map(function(ij) {
+              // should make selectable3 positive
+              if (findIndex([-ij[0], -ij[1]], selectable3) === -1) { out.push(ij); }
+            });
+          } else {
+            selected3.map(function(ij) {
+              if (findIndex(ij, selectable3) > -1) { out.push(ij); }
+            });
+          }
+          selected3 = out;
+        }
+        // Change selected3's value based on selectable3, then
+        // refresh the cell selection state according to values in selected3
+        var selectCells = function(ignoreSelectable) {
+          if (!ignoreSelectable) onlyKeepSelectableCells();
+          table.$('td.' + selClass).removeClass(selClass);
+          if (selected3.length === 0) return;
+          if (server) {
+            table.cells({page: 'current'}).every(function() {
+              var info = tweakCellIndex(this);
+              if (findIndex([info.row, info.col], selected3) > -1)
+                $(this.node()).addClass(selClass);
+            });
+          } else {
+            selected3.map(function(ij) {
+              $(table.cell(ij[0] - 1, ij[1]).node()).addClass(selClass);
+            });
+          }
+        };
+        table.on('click.dt', 'tbody td', function() {
+          var $this = $(this), info = tweakCellIndex(table.cell(this));
+          if ($this.hasClass(selClass)) {
+            $this.removeClass(selClass);
+            selected3.splice(findIndex([info.row, info.col], selected3), 1);
+          } else {
+            if (selMode === 'single') $(table.cells().nodes()).removeClass(selClass);
+            $this.addClass(selClass);
+            selected3 = selMode === 'single' ? [[info.row, info.col]] :
+              unique(selected3.concat([[info.row, info.col]]));
+          }
+          selectCells(false); // must call this to update selected3 based on selectable3
+          changeInput('cells_selected', transposeArray2D(selected3), 'shiny.matrix');
+        });
+        selectCells(false);  // in case users have specified pre-selected columns
+        changeInput('cells_selected', transposeArray2D(selected3), 'shiny.matrix');
+
+        if (server) table.on('draw.dt', function(e) { selectCells(false); });
+        methods.selectCells = function(selected, ignoreSelectable) {
+          selected3 = selected ? selected : [];
+          selectCells(ignoreSelectable);
+          changeInput('cells_selected', transposeArray2D(selected3), 'shiny.matrix');
+        }
+      }
+    }
+
+    // expose some table info to Shiny
+    var updateTableInfo = function(e, settings) {
+      // TODO: is anyone interested in the page info?
+      // changeInput('page_info', table.page.info());
+      var updateRowInfo = function(id, modifier) {
+        var idx;
+        if (server) {
+          idx = modifier.page === 'current' ? DT_rows_current : DT_rows_all;
+        } else {
+          var rows = table.rows($.extend({
+            search: 'applied',
+            page: 'all'
+          }, modifier));
+          idx = addOne(rows.indexes().toArray());
+        }
+        changeInput('rows' + '_' + id, idx);
+      };
+      updateRowInfo('current', {page: 'current'});
+      updateRowInfo('all', {});
+    }
+    table.on('draw.dt', updateTableInfo);
+    updateTableInfo();
+
+    // state info
+    table.on('draw.dt column-visibility.dt', function() {
+      changeInput('state', table.state());
+    });
+    changeInput('state', table.state());
+
+    // search info
+    var updateSearchInfo = function() {
+      changeInput('search', table.search());
+      if (filterRow) changeInput('search_columns', filterRow.toArray().map(function(td) {
+        return $(td).find('input').first().val();
+      }));
+    }
+    table.on('draw.dt', updateSearchInfo);
+    updateSearchInfo();
+
+    var cellInfo = function(thiz) {
+      var info = tweakCellIndex(table.cell(thiz));
+      info.value = table.cell(thiz).data();
+      return info;
+    }
+    // the current cell clicked on
+    table.on('click.dt', 'tbody td', function() {
+      changeInput('cell_clicked', cellInfo(this), null, null, {priority: 'event'});
+    })
+    changeInput('cell_clicked', {});
+
+    // do not trigger table selection when clicking on links unless they have classes
+    table.on('mousedown.dt', 'tbody td a', function(e) {
+      if (this.className === '') e.stopPropagation();
+    });
+
+    methods.addRow = function(data, rowname, resetPaging) {
+      var n = table.columns().indexes().length, d = n - data.length;
+      if (d === 1) {
+        data = rowname.concat(data)
+      } else if (d !== 0) {
+        console.log(data);
+        console.log(table.columns().indexes());
+        throw 'New data must be of the same length as current data (' + n + ')';
+      };
+      table.row.add(data).draw(resetPaging);
+    }
+
+    methods.updateSearch = function(keywords) {
+      if (keywords.global !== null)
+        $(table.table().container()).find('input[type=search]').first()
+             .val(keywords.global).trigger('input');
+      var columns = keywords.columns;
+      if (!filterRow || columns === null) return;
+      filterRow.toArray().map(function(td, i) {
+        var v = typeof columns === 'string' ? columns : columns[i];
+        if (typeof v === 'undefined') {
+          console.log('The search keyword for column ' + i + ' is undefined')
+          return;
+        }
+        // Update column search string and values on linked filter widgets.
+        // 'input' for factor and char filters, 'change' for numeric filters.
+        $(td).find('input').first().val(v).trigger('input', [true]).trigger('change');
+      });
+      table.draw();
+    }
+
+    methods.hideCols = function(hide, reset) {
+      if (reset) table.columns().visible(true, false);
+      table.columns(hide).visible(false);
+    }
+
+    methods.showCols = function(show, reset) {
+      if (reset) table.columns().visible(false, false);
+      table.columns(show).visible(true);
+    }
+
+    methods.colReorder = function(order, origOrder) {
+      table.colReorder.order(order, origOrder);
+    }
+
+    methods.selectPage = function(page) {
+      if (table.page.info().pages < page || page < 1) {
+        throw 'Selected page is out of range';
+      };
+      table.page(page - 1).draw(false);
+    }
+
+    methods.reloadData = function(resetPaging, clearSelection) {
+      // empty selections first if necessary
+      if (methods.selectRows && inArray('row', clearSelection)) methods.selectRows([]);
+      if (methods.selectColumns && inArray('column', clearSelection)) methods.selectColumns([]);
+      if (methods.selectCells && inArray('cell', clearSelection)) methods.selectCells([]);
+      table.ajax.reload(null, resetPaging);
+    }
+
+    // update table filters (set new limits of sliders)
+    methods.updateFilters = function(newProps) {
+      // loop through each filter in the filter row
+      filterRow.each(function(i, td) {
+        var k = i;
+        if (filterRow.length > newProps.length) {
+          if (i === 0) return;  // first column is row names
+          k = i - 1;
+        }
+        // Update the filters to reflect the updated data.
+        // Allow "falsy" (e.g. NULL) to signify a no-op.
+        if (newProps[k]) {
+          setFilterProps(td, newProps[k]);
+        }
+      });
+    };
+
+    table.shinyMethods = methods;
+  },
+  resize: function(el, width, height, instance) {
+    if (instance.data) this.renderValue(el, instance.data, instance);
+
+    // dynamically adjust height if fillContainer = TRUE
+    if (instance.fillContainer)
+      this.fillAvailableHeight(el, height);
+
+    this.adjustWidth(el);
+  },
+
+  // dynamically set the scroll body to fill available height
+  // (used with fillContainer = TRUE)
+  fillAvailableHeight: function(el, availableHeight) {
+
+    // see how much of the table is occupied by header/footer elements
+    // and use that to compute a target scroll body height
+    var dtWrapper = $(el).find('div.dataTables_wrapper');
+    var dtScrollBody = $(el).find($('div.dataTables_scrollBody'));
+    var framingHeight = dtWrapper.innerHeight() - dtScrollBody.innerHeight();
+    var scrollBodyHeight = availableHeight - framingHeight;
+
+    // we need to set `max-height` to none as datatables library now sets this
+    // to a fixed height, disabling the ability to resize to fill the window,
+    // as it will be set to a fixed 100px under such circumstances, e.g., RStudio IDE,
+    // or FlexDashboard
+    // see https://github.com/rstudio/DT/issues/951#issuecomment-1026464509
+    dtScrollBody.css('max-height', 'none');
+    // set the height
+    dtScrollBody.height(scrollBodyHeight + 'px');
+  },
+
+  // adjust the width of columns; remove the hard-coded widths on table and the
+  // scroll header when scrollX/Y are enabled
+  adjustWidth: function(el) {
+    var $el = $(el), table = $el.data('datatable');
+    if (table) table.columns.adjust();
+    $el.find('.dataTables_scrollHeadInner').css('width', '')
+        .children('table').css('margin-left', '');
+  }
+});
+
+  if (!HTMLWidgets.shinyMode) return;
+
+  Shiny.addCustomMessageHandler('datatable-calls', function(data) {
+    var id = data.id;
+    var el = document.getElementById(id);
+    var table = el ? $(el).data('datatable') : null;
+    if (!table) {
+      console.log("Couldn't find table with id " + id);
+      return;
+    }
+
+    var methods = table.shinyMethods, call = data.call;
+    if (methods[call.method]) {
+      methods[call.method].apply(table, call.args);
+    } else {
+      console.log("Unknown method " + call.method);
+    }
+  });
+
+})();
diff --git a/docs/articles/S6_hca_onto_files/dt-core-1.13.6/css/jquery.dataTables.extra.css b/docs/articles/S6_hca_onto_files/dt-core-1.13.6/css/jquery.dataTables.extra.css
new file mode 100644
index 0000000..b2dd141
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/dt-core-1.13.6/css/jquery.dataTables.extra.css
@@ -0,0 +1,28 @@
+/* Selected rows/cells */
+table.dataTable tr.selected td, table.dataTable td.selected {
+  background-color: #b0bed9 !important;
+}
+/* In case of scrollX/Y or FixedHeader */
+.dataTables_scrollBody .dataTables_sizing {
+  visibility: hidden;
+}
+
+/* The datatables' theme CSS file doesn't define
+the color but with white background. It leads to an issue that
+when the HTML's body color is set to 'white', the user can't
+see the text since the background is white. One case happens in the
+RStudio's IDE when inline viewing the DT table inside an Rmd file,
+if the IDE theme is set to "Cobalt".
+
+See https://github.com/rstudio/DT/issues/447 for more info
+
+This fixes should have little side-effects because all the other elements
+of the default theme use the #333 font color.
+
+TODO: The upstream may use relative colors for both the table background
+and the color. It means the table can display well without this patch
+then. At that time, we need to remove the below CSS attributes.
+*/
+div.datatables {
+  color: #333;
+}
diff --git a/docs/articles/S6_hca_onto_files/dt-core-1.13.6/css/jquery.dataTables.min.css b/docs/articles/S6_hca_onto_files/dt-core-1.13.6/css/jquery.dataTables.min.css
new file mode 100644
index 0000000..ad59f84
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/dt-core-1.13.6/css/jquery.dataTables.min.css
@@ -0,0 +1 @@
+:root{--dt-row-selected: 13, 110, 253;--dt-row-selected-text: 255, 255, 255;--dt-row-selected-link: 9, 10, 11;--dt-row-stripe: 0, 0, 0;--dt-row-hover: 0, 0, 0;--dt-column-ordering: 0, 0, 0;--dt-html-background: white}:root.dark{--dt-html-background: rgb(33, 37, 41)}table.dataTable td.dt-control{text-align:center;cursor:pointer}table.dataTable td.dt-control:before{display:inline-block;color:rgba(0, 0, 0, 0.5);content:"►"}table.dataTable tr.dt-hasChild td.dt-control:before{content:"▼"}html.dark table.dataTable td.dt-control:before{color:rgba(255, 255, 255, 0.5)}html.dark table.dataTable tr.dt-hasChild td.dt-control:before{color:rgba(255, 255, 255, 0.5)}table.dataTable thead>tr>th.sorting,table.dataTable thead>tr>th.sorting_asc,table.dataTable thead>tr>th.sorting_desc,table.dataTable thead>tr>th.sorting_asc_disabled,table.dataTable thead>tr>th.sorting_desc_disabled,table.dataTable thead>tr>td.sorting,table.dataTable thead>tr>td.sorting_asc,table.dataTable 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thead>tr>td.sorting_asc_disabled:before,table.dataTable thead>tr>td.sorting_asc_disabled:after,table.dataTable thead>tr>td.sorting_desc_disabled:before,table.dataTable thead>tr>td.sorting_desc_disabled:after{position:absolute;display:block;opacity:.125;right:10px;line-height:9px;font-size:.8em}table.dataTable thead>tr>th.sorting:before,table.dataTable thead>tr>th.sorting_asc:before,table.dataTable thead>tr>th.sorting_desc:before,table.dataTable thead>tr>th.sorting_asc_disabled:before,table.dataTable thead>tr>th.sorting_desc_disabled:before,table.dataTable thead>tr>td.sorting:before,table.dataTable thead>tr>td.sorting_asc:before,table.dataTable thead>tr>td.sorting_desc:before,table.dataTable thead>tr>td.sorting_asc_disabled:before,table.dataTable thead>tr>td.sorting_desc_disabled:before{bottom:50%;content:"▲";content:"▲"/""}table.dataTable thead>tr>th.sorting:after,table.dataTable thead>tr>th.sorting_asc:after,table.dataTable thead>tr>th.sorting_desc:after,table.dataTable thead>tr>th.sorting_asc_disabled:after,table.dataTable thead>tr>th.sorting_desc_disabled:after,table.dataTable thead>tr>td.sorting:after,table.dataTable thead>tr>td.sorting_asc:after,table.dataTable thead>tr>td.sorting_desc:after,table.dataTable thead>tr>td.sorting_asc_disabled:after,table.dataTable thead>tr>td.sorting_desc_disabled:after{top:50%;content:"▼";content:"▼"/""}table.dataTable thead>tr>th.sorting_asc:before,table.dataTable thead>tr>th.sorting_desc:after,table.dataTable thead>tr>td.sorting_asc:before,table.dataTable thead>tr>td.sorting_desc:after{opacity:.6}table.dataTable thead>tr>th.sorting_desc_disabled:after,table.dataTable thead>tr>th.sorting_asc_disabled:before,table.dataTable thead>tr>td.sorting_desc_disabled:after,table.dataTable thead>tr>td.sorting_asc_disabled:before{display:none}table.dataTable thead>tr>th:active,table.dataTable 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new file mode 100644
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diff --git a/docs/articles/S6_hca_onto_files/htmltools-fill-0.5.8.1/fill.css b/docs/articles/S6_hca_onto_files/htmltools-fill-0.5.8.1/fill.css
new file mode 100644
index 0000000..841ea9d
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/htmltools-fill-0.5.8.1/fill.css
@@ -0,0 +1,21 @@
+@layer htmltools {
+  .html-fill-container {
+    display: flex;
+    flex-direction: column;
+    /* Prevent the container from expanding vertically or horizontally beyond its
+    parent's constraints. */
+    min-height: 0;
+    min-width: 0;
+  }
+  .html-fill-container > .html-fill-item {
+    /* Fill items can grow and shrink freely within
+    available vertical space in fillable container */
+    flex: 1 1 auto;
+    min-height: 0;
+    min-width: 0;
+  }
+  .html-fill-container > :not(.html-fill-item) {
+    /* Prevent shrinking or growing of non-fill items */
+    flex: 0 0 auto;
+  }
+}
diff --git a/docs/articles/S6_hca_onto_files/htmlwidgets-1.6.4/htmlwidgets.js b/docs/articles/S6_hca_onto_files/htmlwidgets-1.6.4/htmlwidgets.js
new file mode 100644
index 0000000..1067d02
--- /dev/null
+++ b/docs/articles/S6_hca_onto_files/htmlwidgets-1.6.4/htmlwidgets.js
@@ -0,0 +1,901 @@
+(function() {
+  // If window.HTMLWidgets is already defined, then use it; otherwise create a
+  // new object. This allows preceding code to set options that affect the
+  // initialization process (though none currently exist).
+  window.HTMLWidgets = window.HTMLWidgets || {};
+
+  // See if we're running in a viewer pane. If not, we're in a web browser.
+  var viewerMode = window.HTMLWidgets.viewerMode =
+      /\bviewer_pane=1\b/.test(window.location);
+
+  // See if we're running in Shiny mode. If not, it's a static document.
+  // Note that static widgets can appear in both Shiny and static modes, but
+  // obviously, Shiny widgets can only appear in Shiny apps/documents.
+  var shinyMode = window.HTMLWidgets.shinyMode =
+      typeof(window.Shiny) !== "undefined" && !!window.Shiny.outputBindings;
+
+  // We can't count on jQuery being available, so we implement our own
+  // version if necessary.
+  function querySelectorAll(scope, selector) {
+    if (typeof(jQuery) !== "undefined" && scope instanceof jQuery) {
+      return scope.find(selector);
+    }
+    if (scope.querySelectorAll) {
+      return scope.querySelectorAll(selector);
+    }
+  }
+
+  function asArray(value) {
+    if (value === null)
+      return [];
+    if ($.isArray(value))
+      return value;
+    return [value];
+  }
+
+  // Implement jQuery's extend
+  function extend(target /*, ... */) {
+    if (arguments.length == 1) {
+      return target;
+    }
+    for (var i = 1; i < arguments.length; i++) {
+      var source = arguments[i];
+      for (var prop in source) {
+        if (source.hasOwnProperty(prop)) {
+          target[prop] = source[prop];
+        }
+      }
+    }
+    return target;
+  }
+
+  // IE8 doesn't support Array.forEach.
+  function forEach(values, callback, thisArg) {
+    if (values.forEach) {
+      values.forEach(callback, thisArg);
+    } else {
+      for (var i = 0; i < values.length; i++) {
+        callback.call(thisArg, values[i], i, values);
+      }
+    }
+  }
+
+  // Replaces the specified method with the return value of funcSource.
+  //
+  // Note that funcSource should not BE the new method, it should be a function
+  // that RETURNS the new method. funcSource receives a single argument that is
+  // the overridden method, it can be called from the new method. The overridden
+  // method can be called like a regular function, it has the target permanently
+  // bound to it so "this" will work correctly.
+  function overrideMethod(target, methodName, funcSource) {
+    var superFunc = target[methodName] || function() {};
+    var superFuncBound = function() {
+      return superFunc.apply(target, arguments);
+    };
+    target[methodName] = funcSource(superFuncBound);
+  }
+
+  // Add a method to delegator that, when invoked, calls
+  // delegatee.methodName. If there is no such method on
+  // the delegatee, but there was one on delegator before
+  // delegateMethod was called, then the original version
+  // is invoked instead.
+  // For example:
+  //
+  // var a = {
+  //   method1: function() { console.log('a1'); }
+  //   method2: function() { console.log('a2'); }
+  // };
+  // var b = {
+  //   method1: function() { console.log('b1'); }
+  // };
+  // delegateMethod(a, b, "method1");
+  // delegateMethod(a, b, "method2");
+  // a.method1();
+  // a.method2();
+  //
+  // The output would be "b1", "a2".
+  function delegateMethod(delegator, delegatee, methodName) {
+    var inherited = delegator[methodName];
+    delegator[methodName] = function() {
+      var target = delegatee;
+      var method = delegatee[methodName];
+
+      // The method doesn't exist on the delegatee. Instead,
+      // call the method on the delegator, if it exists.
+      if (!method) {
+        target = delegator;
+        method = inherited;
+      }
+
+      if (method) {
+        return method.apply(target, arguments);
+      }
+    };
+  }
+
+  // Implement a vague facsimilie of jQuery's data method
+  function elementData(el, name, value) {
+    if (arguments.length == 2) {
+      return el["htmlwidget_data_" + name];
+    } else if (arguments.length == 3) {
+      el["htmlwidget_data_" + name] = value;
+      return el;
+    } else {
+      throw new Error("Wrong number of arguments for elementData: " +
+        arguments.length);
+    }
+  }
+
+  // http://stackoverflow.com/questions/3446170/escape-string-for-use-in-javascript-regex
+  function escapeRegExp(str) {
+    return str.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g, "\\$&");
+  }
+
+  function hasClass(el, className) {
+    var re = new RegExp("\\b" + escapeRegExp(className) + "\\b");
+    return re.test(el.className);
+  }
+
+  // elements - array (or array-like object) of HTML elements
+  // className - class name to test for
+  // include - if true, only return elements with given className;
+  //   if false, only return elements *without* given className
+  function filterByClass(elements, className, include) {
+    var results = [];
+    for (var i = 0; i < elements.length; i++) {
+      if (hasClass(elements[i], className) == include)
+        results.push(elements[i]);
+    }
+    return results;
+  }
+
+  function on(obj, eventName, func) {
+    if (obj.addEventListener) {
+      obj.addEventListener(eventName, func, false);
+    } else if (obj.attachEvent) {
+      obj.attachEvent(eventName, func);
+    }
+  }
+
+  function off(obj, eventName, func) {
+    if (obj.removeEventListener)
+      obj.removeEventListener(eventName, func, false);
+    else if (obj.detachEvent) {
+      obj.detachEvent(eventName, func);
+    }
+  }
+
+  // Translate array of values to top/right/bottom/left, as usual with
+  // the "padding" CSS property
+  // https://developer.mozilla.org/en-US/docs/Web/CSS/padding
+  function unpackPadding(value) {
+    if (typeof(value) === "number")
+      value = [value];
+    if (value.length === 1) {
+      return {top: value[0], right: value[0], bottom: value[0], left: value[0]};
+    }
+    if (value.length === 2) {
+      return {top: value[0], right: value[1], bottom: value[0], left: value[1]};
+    }
+    if (value.length === 3) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[1]};
+    }
+    if (value.length === 4) {
+      return {top: value[0], right: value[1], bottom: value[2], left: value[3]};
+    }
+  }
+
+  // Convert an unpacked padding object to a CSS value
+  function paddingToCss(paddingObj) {
+    return paddingObj.top + "px " + paddingObj.right + "px " + paddingObj.bottom + "px " + paddingObj.left + "px";
+  }
+
+  // Makes a number suitable for CSS
+  function px(x) {
+    if (typeof(x) === "number")
+      return x + "px";
+    else
+      return x;
+  }
+
+  // Retrieves runtime widget sizing information for an element.
+  // The return value is either null, or an object with fill, padding,
+  // defaultWidth, defaultHeight fields.
+  function sizingPolicy(el) {
+    var sizingEl = document.querySelector("script[data-for='" + el.id + "'][type='application/htmlwidget-sizing']");
+    if (!sizingEl)
+      return null;
+    var sp = JSON.parse(sizingEl.textContent || sizingEl.text || "{}");
+    if (viewerMode) {
+      return sp.viewer;
+    } else {
+      return sp.browser;
+    }
+  }
+
+  // @param tasks Array of strings (or falsy value, in which case no-op).
+  //   Each element must be a valid JavaScript expression that yields a
+  //   function. Or, can be an array of objects with "code" and "data"
+  //   properties; in this case, the "code" property should be a string
+  //   of JS that's an expr that yields a function, and "data" should be
+  //   an object that will be added as an additional argument when that
+  //   function is called.
+  // @param target The object that will be "this" for each function
+  //   execution.
+  // @param args Array of arguments to be passed to the functions. (The
+  //   same arguments will be passed to all functions.)
+  function evalAndRun(tasks, target, args) {
+    if (tasks) {
+      forEach(tasks, function(task) {
+        var theseArgs = args;
+        if (typeof(task) === "object") {
+          theseArgs = theseArgs.concat([task.data]);
+          task = task.code;
+        }
+        var taskFunc = tryEval(task);
+        if (typeof(taskFunc) !== "function") {
+          throw new Error("Task must be a function! Source:\n" + task);
+        }
+        taskFunc.apply(target, theseArgs);
+      });
+    }
+  }
+
+  // Attempt eval() both with and without enclosing in parentheses.
+  // Note that enclosing coerces a function declaration into
+  // an expression that eval() can parse
+  // (otherwise, a SyntaxError is thrown)
+  function tryEval(code) {
+    var result = null;
+    try {
+      result = eval("(" + code + ")");
+    } catch(error) {
+      if (!(error instanceof SyntaxError)) {
+        throw error;
+      }
+      try {
+        result = eval(code);
+      } catch(e) {
+        if (e instanceof SyntaxError) {
+          throw error;
+        } else {
+          throw e;
+        }
+      }
+    }
+    return result;
+  }
+
+  function initSizing(el) {
+    var sizing = sizingPolicy(el);
+    if (!sizing)
+      return;
+
+    var cel = document.getElementById("htmlwidget_container");
+    if (!cel)
+      return;
+
+    if (typeof(sizing.padding) !== "undefined") {
+      document.body.style.margin = "0";
+      document.body.style.padding = paddingToCss(unpackPadding(sizing.padding));
+    }
+
+    if (sizing.fill) {
+      document.body.style.overflow = "hidden";
+      document.body.style.width = "100%";
+      document.body.style.height = "100%";
+      document.documentElement.style.width = "100%";
+      document.documentElement.style.height = "100%";
+      cel.style.position = "absolute";
+      var pad = unpackPadding(sizing.padding);
+      cel.style.top = pad.top + "px";
+      cel.style.right = pad.right + "px";
+      cel.style.bottom = pad.bottom + "px";
+      cel.style.left = pad.left + "px";
+      el.style.width = "100%";
+      el.style.height = "100%";
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+
+    } else {
+      el.style.width = px(sizing.width);
+      el.style.height = px(sizing.height);
+
+      return {
+        getWidth: function() { return cel.getBoundingClientRect().width; },
+        getHeight: function() { return cel.getBoundingClientRect().height; }
+      };
+    }
+  }
+
+  // Default implementations for methods
+  var defaults = {
+    find: function(scope) {
+      return querySelectorAll(scope, "." + this.name);
+    },
+    renderError: function(el, err) {
+      var $el = $(el);
+
+      this.clearError(el);
+
+      // Add all these error classes, as Shiny does
+      var errClass = "shiny-output-error";
+      if (err.type !== null) {
+        // use the classes of the error condition as CSS class names
+        errClass = errClass + " " + $.map(asArray(err.type), function(type) {
+          return errClass + "-" + type;
+        }).join(" ");
+      }
+      errClass = errClass + " htmlwidgets-error";
+
+      // Is el inline or block? If inline or inline-block, just display:none it
+      // and add an inline error.
+      var display = $el.css("display");
+      $el.data("restore-display-mode", display);
+
+      if (display === "inline" || display === "inline-block") {
+        $el.hide();
+        if (err.message !== "") {
+          var errorSpan = $("<span>").addClass(errClass);
+          errorSpan.text(err.message);
+          $el.after(errorSpan);
+        }
+      } else if (display === "block") {
+        // If block, add an error just after the el, set visibility:none on the
+        // el, and position the error to be on top of the el.
+        // Mark it with a unique ID and CSS class so we can remove it later.
+        $el.css("visibility", "hidden");
+        if (err.message !== "") {
+          var errorDiv = $("<div>").addClass(errClass).css("position", "absolute")
+            .css("top", el.offsetTop)
+            .css("left", el.offsetLeft)
+            // setting width can push out the page size, forcing otherwise
+            // unnecessary scrollbars to appear and making it impossible for
+            // the element to shrink; so use max-width instead
+            .css("maxWidth", el.offsetWidth)
+            .css("height", el.offsetHeight);
+          errorDiv.text(err.message);
+          $el.after(errorDiv);
+
+          // Really dumb way to keep the size/position of the error in sync with
+          // the parent element as the window is resized or whatever.
+          var intId = setInterval(function() {
+            if (!errorDiv[0].parentElement) {
+              clearInterval(intId);
+              return;
+            }
+            errorDiv
+              .css("top", el.offsetTop)
+              .css("left", el.offsetLeft)
+              .css("maxWidth", el.offsetWidth)
+              .css("height", el.offsetHeight);
+          }, 500);
+        }
+      }
+    },
+    clearError: function(el) {
+      var $el = $(el);
+      var display = $el.data("restore-display-mode");
+      $el.data("restore-display-mode", null);
+
+      if (display === "inline" || display === "inline-block") {
+        if (display)
+          $el.css("display", display);
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      } else if (display === "block"){
+        $el.css("visibility", "inherit");
+        $(el.nextSibling).filter(".htmlwidgets-error").remove();
+      }
+    },
+    sizing: {}
+  };
+
+  // Called by widget bindings to register a new type of widget. The definition
+  // object can contain the following properties:
+  // - name (required) - A string indicating the binding name, which will be
+  //   used by default as the CSS classname to look for.
+  // - initialize (optional) - A function(el) that will be called once per
+  //   widget element; if a value is returned, it will be passed as the third
+  //   value to renderValue.
+  // - renderValue (required) - A function(el, data, initValue) that will be
+  //   called with data. Static contexts will cause this to be called once per
+  //   element; Shiny apps will cause this to be called multiple times per
+  //   element, as the data changes.
+  window.HTMLWidgets.widget = function(definition) {
+    if (!definition.name) {
+      throw new Error("Widget must have a name");
+    }
+    if (!definition.type) {
+      throw new Error("Widget must have a type");
+    }
+    // Currently we only support output widgets
+    if (definition.type !== "output") {
+      throw new Error("Unrecognized widget type '" + definition.type + "'");
+    }
+    // TODO: Verify that .name is a valid CSS classname
+
+    // Support new-style instance-bound definitions. Old-style class-bound
+    // definitions have one widget "object" per widget per type/class of
+    // widget; the renderValue and resize methods on such widget objects
+    // take el and instance arguments, because the widget object can't
+    // store them. New-style instance-bound definitions have one widget
+    // object per widget instance; the definition that's passed in doesn't
+    // provide renderValue or resize methods at all, just the single method
+    //   factory(el, width, height)
+    // which returns an object that has renderValue(x) and resize(w, h).
+    // This enables a far more natural programming style for the widget
+    // author, who can store per-instance state using either OO-style
+    // instance fields or functional-style closure variables (I guess this
+    // is in contrast to what can only be called C-style pseudo-OO which is
+    // what we required before).
+    if (definition.factory) {
+      definition = createLegacyDefinitionAdapter(definition);
+    }
+
+    if (!definition.renderValue) {
+      throw new Error("Widget must have a renderValue function");
+    }
+
+    // For static rendering (non-Shiny), use a simple widget registration
+    // scheme. We also use this scheme for Shiny apps/documents that also
+    // contain static widgets.
+    window.HTMLWidgets.widgets = window.HTMLWidgets.widgets || [];
+    // Merge defaults into the definition; don't mutate the original definition.
+    var staticBinding = extend({}, defaults, definition);
+    overrideMethod(staticBinding, "find", function(superfunc) {
+      return function(scope) {
+        var results = superfunc(scope);
+        // Filter out Shiny outputs, we only want the static kind
+        return filterByClass(results, "html-widget-output", false);
+      };
+    });
+    window.HTMLWidgets.widgets.push(staticBinding);
+
+    if (shinyMode) {
+      // Shiny is running. Register the definition with an output binding.
+      // The definition itself will not be the output binding, instead
+      // we will make an output binding object that delegates to the
+      // definition. This is because we foolishly used the same method
+      // name (renderValue) for htmlwidgets definition and Shiny bindings
+      // but they actually have quite different semantics (the Shiny
+      // bindings receive data that includes lots of metadata that it
+      // strips off before calling htmlwidgets renderValue). We can't
+      // just ignore the difference because in some widgets it's helpful
+      // to call this.renderValue() from inside of resize(), and if
+      // we're not delegating, then that call will go to the Shiny
+      // version instead of the htmlwidgets version.
+
+      // Merge defaults with definition, without mutating either.
+      var bindingDef = extend({}, defaults, definition);
+
+      // This object will be our actual Shiny binding.
+      var shinyBinding = new Shiny.OutputBinding();
+
+      // With a few exceptions, we'll want to simply use the bindingDef's
+      // version of methods if they are available, otherwise fall back to
+      // Shiny's defaults. NOTE: If Shiny's output bindings gain additional
+      // methods in the future, and we want them to be overrideable by
+      // HTMLWidget binding definitions, then we'll need to add them to this
+      // list.
+      delegateMethod(shinyBinding, bindingDef, "getId");
+      delegateMethod(shinyBinding, bindingDef, "onValueChange");
+      delegateMethod(shinyBinding, bindingDef, "onValueError");
+      delegateMethod(shinyBinding, bindingDef, "renderError");
+      delegateMethod(shinyBinding, bindingDef, "clearError");
+      delegateMethod(shinyBinding, bindingDef, "showProgress");
+
+      // The find, renderValue, and resize are handled differently, because we
+      // want to actually decorate the behavior of the bindingDef methods.
+
+      shinyBinding.find = function(scope) {
+        var results = bindingDef.find(scope);
+
+        // Only return elements that are Shiny outputs, not static ones
+        var dynamicResults = results.filter(".html-widget-output");
+
+        // It's possible that whatever caused Shiny to think there might be
+        // new dynamic outputs, also caused there to be new static outputs.
+        // Since there might be lots of different htmlwidgets bindings, we
+        // schedule execution for later--no need to staticRender multiple
+        // times.
+        if (results.length !== dynamicResults.length)
+          scheduleStaticRender();
+
+        return dynamicResults;
+      };
+
+      // Wrap renderValue to handle initialization, which unfortunately isn't
+      // supported natively by Shiny at the time of this writing.
+
+      shinyBinding.renderValue = function(el, data) {
+        Shiny.renderDependencies(data.deps);
+        // Resolve strings marked as javascript literals to objects
+        if (!(data.evals instanceof Array)) data.evals = [data.evals];
+        for (var i = 0; data.evals && i < data.evals.length; i++) {
+          window.HTMLWidgets.evaluateStringMember(data.x, data.evals[i]);
+        }
+        if (!bindingDef.renderOnNullValue) {
+          if (data.x === null) {
+            el.style.visibility = "hidden";
+            return;
+          } else {
+            el.style.visibility = "inherit";
+          }
+        }
+        if (!elementData(el, "initialized")) {
+          initSizing(el);
+
+          elementData(el, "initialized", true);
+          if (bindingDef.initialize) {
+            var rect = el.getBoundingClientRect();
+            var result = bindingDef.initialize(el, rect.width, rect.height);
+            elementData(el, "init_result", result);
+          }
+        }
+        bindingDef.renderValue(el, data.x, elementData(el, "init_result"));
+        evalAndRun(data.jsHooks.render, elementData(el, "init_result"), [el, data.x]);
+      };
+
+      // Only override resize if bindingDef implements it
+      if (bindingDef.resize) {
+        shinyBinding.resize = function(el, width, height) {
+          // Shiny can call resize before initialize/renderValue have been
+          // called, which doesn't make sense for widgets.
+          if (elementData(el, "initialized")) {
+            bindingDef.resize(el, width, height, elementData(el, "init_result"));
+          }
+        };
+      }
+
+      Shiny.outputBindings.register(shinyBinding, bindingDef.name);
+    }
+  };
+
+  var scheduleStaticRenderTimerId = null;
+  function scheduleStaticRender() {
+    if (!scheduleStaticRenderTimerId) {
+      scheduleStaticRenderTimerId = setTimeout(function() {
+        scheduleStaticRenderTimerId = null;
+        window.HTMLWidgets.staticRender();
+      }, 1);
+    }
+  }
+
+  // Render static widgets after the document finishes loading
+  // Statically render all elements that are of this widget's class
+  window.HTMLWidgets.staticRender = function() {
+    var bindings = window.HTMLWidgets.widgets || [];
+    forEach(bindings, function(binding) {
+      var matches = binding.find(document.documentElement);
+      forEach(matches, function(el) {
+        var sizeObj = initSizing(el, binding);
+
+        var getSize = function(el) {
+          if (sizeObj) {
+            return {w: sizeObj.getWidth(), h: sizeObj.getHeight()}
+          } else {
+            var rect = el.getBoundingClientRect();
+            return {w: rect.width, h: rect.height}
+          }
+        };
+
+        if (hasClass(el, "html-widget-static-bound"))
+          return;
+        el.className = el.className + " html-widget-static-bound";
+
+        var initResult;
+        if (binding.initialize) {
+          var size = getSize(el);
+          initResult = binding.initialize(el, size.w, size.h);
+          elementData(el, "init_result", initResult);
+        }
+
+        if (binding.resize) {
+          var lastSize = getSize(el);
+          var resizeHandler = function(e) {
+            var size = getSize(el);
+            if (size.w === 0 && size.h === 0)
+              return;
+            if (size.w === lastSize.w && size.h === lastSize.h)
+              return;
+            lastSize = size;
+            binding.resize(el, size.w, size.h, initResult);
+          };
+
+          on(window, "resize", resizeHandler);
+
+          // This is needed for cases where we're running in a Shiny
+          // app, but the widget itself is not a Shiny output, but
+          // rather a simple static widget. One example of this is
+          // an rmarkdown document that has runtime:shiny and widget
+          // that isn't in a render function. Shiny only knows to
+          // call resize handlers for Shiny outputs, not for static
+          // widgets, so we do it ourselves.
+          if (window.jQuery) {
+            window.jQuery(document).on(
+              "shown.htmlwidgets shown.bs.tab.htmlwidgets shown.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+            window.jQuery(document).on(
+              "hidden.htmlwidgets hidden.bs.tab.htmlwidgets hidden.bs.collapse.htmlwidgets",
+              resizeHandler
+            );
+          }
+
+          // This is needed for the specific case of ioslides, which
+          // flips slides between display:none and display:block.
+          // Ideally we would not have to have ioslide-specific code
+          // here, but rather have ioslides raise a generic event,
+          // but the rmarkdown package just went to CRAN so the
+          // window to getting that fixed may be long.
+          if (window.addEventListener) {
+            // It's OK to limit this to window.addEventListener
+            // browsers because ioslides itself only supports
+            // such browsers.
+            on(document, "slideenter", resizeHandler);
+            on(document, "slideleave", resizeHandler);
+          }
+        }
+
+        var scriptData = document.querySelector("script[data-for='" + el.id + "'][type='application/json']");
+        if (scriptData) {
+          var data = JSON.parse(scriptData.textContent || scriptData.text);
+          // Resolve strings marked as javascript literals to objects
+          if (!(data.evals instanceof Array)) data.evals = [data.evals];
+          for (var k = 0; data.evals && k < data.evals.length; k++) {
+            window.HTMLWidgets.evaluateStringMember(data.x, data.evals[k]);
+          }
+          binding.renderValue(el, data.x, initResult);
+          evalAndRun(data.jsHooks.render, initResult, [el, data.x]);
+        }
+      });
+    });
+
+    invokePostRenderHandlers();
+  }
+
+
+  function has_jQuery3() {
+    if (!window.jQuery) {
+      return false;
+    }
+    var $version = window.jQuery.fn.jquery;
+    var $major_version = parseInt($version.split(".")[0]);
+    return $major_version >= 3;
+  }
+
+  /*
+  / Shiny 1.4 bumped jQuery from 1.x to 3.x which means jQuery's
+  / on-ready handler (i.e., $(fn)) is now asyncronous (i.e., it now
+  / really means $(setTimeout(fn)).
+  / https://jquery.com/upgrade-guide/3.0/#breaking-change-document-ready-handlers-are-now-asynchronous
+  /
+  / Since Shiny uses $() to schedule initShiny, shiny>=1.4 calls initShiny
+  / one tick later than it did before, which means staticRender() is
+  / called renderValue() earlier than (advanced) widget authors might be expecting.
+  / https://github.com/rstudio/shiny/issues/2630
+  /
+  / For a concrete example, leaflet has some methods (e.g., updateBounds)
+  / which reference Shiny methods registered in initShiny (e.g., setInputValue).
+  / Since leaflet is privy to this life-cycle, it knows to use setTimeout() to
+  / delay execution of those methods (until Shiny methods are ready)
+  / https://github.com/rstudio/leaflet/blob/18ec981/javascript/src/index.js#L266-L268
+  /
+  / Ideally widget authors wouldn't need to use this setTimeout() hack that
+  / leaflet uses to call Shiny methods on a staticRender(). In the long run,
+  / the logic initShiny should be broken up so that method registration happens
+  / right away, but binding happens later.
+  */
+  function maybeStaticRenderLater() {
+    if (shinyMode && has_jQuery3()) {
+      window.jQuery(window.HTMLWidgets.staticRender);
+    } else {
+      window.HTMLWidgets.staticRender();
+    }
+  }
+
+  if (document.addEventListener) {
+    document.addEventListener("DOMContentLoaded", function() {
+      document.removeEventListener("DOMContentLoaded", arguments.callee, false);
+      maybeStaticRenderLater();
+    }, false);
+  } else if (document.attachEvent) {
+    document.attachEvent("onreadystatechange", function() {
+      if (document.readyState === "complete") {
+        document.detachEvent("onreadystatechange", arguments.callee);
+        maybeStaticRenderLater();
+      }
+    });
+  }
+
+
+  window.HTMLWidgets.getAttachmentUrl = function(depname, key) {
+    // If no key, default to the first item
+    if (typeof(key) === "undefined")
+      key = 1;
+
+    var link = document.getElementById(depname + "-" + key + "-attachment");
+    if (!link) {
+      throw new Error("Attachment " + depname + "/" + key + " not found in document");
+    }
+    return link.getAttribute("href");
+  };
+
+  window.HTMLWidgets.dataframeToD3 = function(df) {
+    var names = [];
+    var length;
+    for (var name in df) {
+        if (df.hasOwnProperty(name))
+            names.push(name);
+        if (typeof(df[name]) !== "object" || typeof(df[name].length) === "undefined") {
+            throw new Error("All fields must be arrays");
+        } else if (typeof(length) !== "undefined" && length !== df[name].length) {
+            throw new Error("All fields must be arrays of the same length");
+        }
+        length = df[name].length;
+    }
+    var results = [];
+    var item;
+    for (var row = 0; row < length; row++) {
+        item = {};
+        for (var col = 0; col < names.length; col++) {
+            item[names[col]] = df[names[col]][row];
+        }
+        results.push(item);
+    }
+    return results;
+  };
+
+  window.HTMLWidgets.transposeArray2D = function(array) {
+      if (array.length === 0) return array;
+      var newArray = array[0].map(function(col, i) {
+          return array.map(function(row) {
+              return row[i]
+          })
+      });
+      return newArray;
+  };
+  // Split value at splitChar, but allow splitChar to be escaped
+  // using escapeChar. Any other characters escaped by escapeChar
+  // will be included as usual (including escapeChar itself).
+  function splitWithEscape(value, splitChar, escapeChar) {
+    var results = [];
+    var escapeMode = false;
+    var currentResult = "";
+    for (var pos = 0; pos < value.length; pos++) {
+      if (!escapeMode) {
+        if (value[pos] === splitChar) {
+          results.push(currentResult);
+          currentResult = "";
+        } else if (value[pos] === escapeChar) {
+          escapeMode = true;
+        } else {
+          currentResult += value[pos];
+        }
+      } else {
+        currentResult += value[pos];
+        escapeMode = false;
+      }
+    }
+    if (currentResult !== "") {
+      results.push(currentResult);
+    }
+    return results;
+  }
+  // Function authored by Yihui/JJ Allaire
+  window.HTMLWidgets.evaluateStringMember = function(o, member) {
+    var parts = splitWithEscape(member, '.', '\\');
+    for (var i = 0, l = parts.length; i < l; i++) {
+      var part = parts[i];
+      // part may be a character or 'numeric' member name
+      if (o !== null && typeof o === "object" && part in o) {
+        if (i == (l - 1)) { // if we are at the end of the line then evalulate
+          if (typeof o[part] === "string")
+            o[part] = tryEval(o[part]);
+        } else { // otherwise continue to next embedded object
+          o = o[part];
+        }
+      }
+    }
+  };
+
+  // Retrieve the HTMLWidget instance (i.e. the return value of an
+  // HTMLWidget binding's initialize() or factory() function)
+  // associated with an element, or null if none.
+  window.HTMLWidgets.getInstance = function(el) {
+    return elementData(el, "init_result");
+  };
+
+  // Finds the first element in the scope that matches the selector,
+  // and returns the HTMLWidget instance (i.e. the return value of
+  // an HTMLWidget binding's initialize() or factory() function)
+  // associated with that element, if any. If no element matches the
+  // selector, or the first matching element has no HTMLWidget
+  // instance associated with it, then null is returned.
+  //
+  // The scope argument is optional, and defaults to window.document.
+  window.HTMLWidgets.find = function(scope, selector) {
+    if (arguments.length == 1) {
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-      <img src="" class="logo" alt=""><h1>S7 Neural net concepts and applications</h1>
+
+      <h1>S7 Neural net concepts and applications</h1>
                         <h4 data-toc-skip class="author">Vincent J. Carey, stvjc at channing.harvard.edu</h4>
             
-            <h4 data-toc-skip class="date">July 11, 2023</h4>
+            <h4 data-toc-skip class="date">November 02, 2024</h4>
       
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/vignettes/S7_cnn.Rmd" class="external-link"><code>vignettes/S7_cnn.Rmd</code></a></small>
       <div class="d-none name"><code>S7_cnn.Rmd</code></div>
@@ -106,15 +96,9 @@ <h2 id="introductory-remarks">Introductory remarks<a class="anchor" aria-label="
 <h2 id="road-map">Road map<a class="anchor" aria-label="anchor" href="#road-map"></a>
 </h2>
 <ul>
-<li>ImageArray</li>
-<li>
-<a href="https://hastie.su.domains/ISLR2/ISLRv2_corrected_June_2023.pdf" class="external-link">ISLR</a> Convolutional Neural Net example
-<ul>
-<li>there is also a <a href="https://hastie.su.domains/ISLP/ISLP_website.pdf" class="external-link">python version</a> of ISLR</li>
-<li>also see <a href="https://www.jeremyjordan.me/convolutional-neural-networks/" class="external-link">Jeremy Jordan</a> explanations</li>
-</ul>
-</li>
-<li>Sfaira model zoo of embeddings and classifiers</li>
+<li><p>ImageArray</p></li>
+<li><p><a href="https://hastie.su.domains/ISLR2/ISLRv2_corrected_June_2023.pdf" class="external-link">ISLR</a> (also a <a href="https://hastie.su.domains/ISLP/ISLP_website.pdf" class="external-link">python version</a> Convolutional Neural Net example (also see <a href="https://www.jeremyjordan.me/convolutional-neural-networks/" class="external-link">Jeremy Jordan</a></p></li>
+<li><p>Sfaira model zoo of embeddings and classifiers</p></li>
 </ul>
 </div>
 <div class="section level2">
@@ -181,7 +165,7 @@ <h2 id="a-trained-classifier-that-ingests-jpgs-as-arrays-and-returns-scores-for-
 <span><span class="co">##     class(ans) = c("islr_cnn", "list")</span></span>
 <span><span class="co">##     ans</span></span>
 <span><span class="co">## }</span></span>
-<span><span class="co">## &lt;bytecode: 0x557d3ee09510&gt;</span></span>
+<span><span class="co">## &lt;bytecode: 0x130cafe28&gt;</span></span>
 <span><span class="co">## &lt;environment: namespace:littleDeep&gt;</span></span></code></pre>
 </div>
 <div class="section level2">
@@ -189,28 +173,26 @@ <h2 id="sfaira-a-model-zoo-of-pretrained-embedders-and-cell-type-classifiers-fro
 </h2>
 <p>We’ll look at <a href="https://vjcitn.github.io/BiocSfaira" class="external-link">the pkgdown site</a>, specifically “get started” tab.</p>
 </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside>
 </div>
 
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
 </div>
 
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-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
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diff --git a/docs/articles/index.html b/docs/articles/index.html
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+    <li><a class="dropdown-item" href="../articles/S1b_hyper.html">S1a: A look at the hypergeometric distribution</a></li>
+    <li><a class="dropdown-item" href="../articles/S2_EDA.html">S2_EDA: Exploratory data analysis and visualization</a></li>
+    <li><a class="dropdown-item" href="../articles/S2a_PCAelem.html">S2a: Elements of PCA</a></li>
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+    <li><a class="dropdown-item" href="../articles/S5a_lmdiagnostics.html">S5a: Diagnostics of a differential gene expression exercise</a></li>
+    <li><a class="dropdown-item" href="../articles/S5b_nonlin.html">S5b: hypothesis testing in nonlinear regression</a></li>
+    <li><a class="dropdown-item" href="../articles/S6_hca_onto.html">S6 HCA, ontologies, shiny</a></li>
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+  </ul></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
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+
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   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Articles</h1>
+
+      <h1>Articles</h1>
     </div>
 
     <div class="section ">
       <h3>All vignettes</h3>
-      <p class="section-desc"></p>
+      <div class="section-desc"></div>
 
       <dl><dt><a href="S1_probability.html">S1_probability: Definitions and exercises</a></dt>
         <dd>
@@ -87,18 +75,18 @@ <h3>All vignettes</h3>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
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diff --git a/docs/authors.html b/docs/authors.html
index 7179e49..3f6cb2b 100644
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+++ b/docs/authors.html
@@ -1,103 +1,92 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Authors and Citation • CSHstats</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.2.2/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.2.2/bootstrap.bundle.min.js"></script><link href="deps/Roboto-0.4.6/font.css" rel="stylesheet"><link href="deps/Courier_Prime-0.4.6/font.css" rel="stylesheet"><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Authors and Citation"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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-<![endif]--></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Authors and Citation • CSHstats</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/Roboto-0.4.9/font.css" rel="stylesheet"><link href="deps/Courier_Prime-0.4.9/font.css" rel="stylesheet"><link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Authors and Citation"></head><body>
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.0.33</small>
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+    <li><a class="dropdown-item" href="articles/S5a_lmdiagnostics.html">S5a: Diagnostics of a differential gene expression exercise</a></li>
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+  </ul></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="search.json"></form></li>
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+
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 </nav><div class="container template-citation-authors">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Authors and Citation</h1>
+
+      <h1>Authors and Citation</h1>
     </div>
 
-    <div class="section level2 citation">
+    <div class="section level2">
       <h2>Authors</h2>
-      
+
       <ul class="list-unstyled"><li>
           <p><strong>Vince Carey</strong>. Author, maintainer. <a href="https://orcid.org/0000-0003-4046-0063" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a>
           </p>
         </li>
       </ul></div>
 
-    <div class="section level2 citation">
+    <div class="section level2">
       <h2 id="citation">Citation</h2>
       <p><small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/DESCRIPTION" class="external-link"><code>DESCRIPTION</code></a></small></p>
 
-      <p>Carey V (2023).
+      <p>Carey V (2024).
 <em>CSHstats: discussions and exercises on classical statistics for CSHL 2022</em>.
-R package version 0.0.33, <a href="https://github.com/vjcitn/CSHstats" class="external-link">https://github.com/vjcitn/CSHstats</a>. 
+R package version 0.0.34, <a href="https://github.com/vjcitn/CSHstats" class="external-link">https://github.com/vjcitn/CSHstats</a>.
 </p>
       <pre>@Manual{,
   title = {CSHstats: discussions and exercises on classical statistics for CSHL 2022},
   author = {Vince Carey},
-  year = {2023},
-  note = {R package version 0.0.33},
+  year = {2024},
+  note = {R package version 0.0.34},
   url = {https://github.com/vjcitn/CSHstats},
 }</pre>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
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diff --git a/docs/deps/Courier_Prime-0.4.9/font.css b/docs/deps/Courier_Prime-0.4.9/font.css
new file mode 100644
index 0000000..b38b406
--- /dev/null
+++ b/docs/deps/Courier_Prime-0.4.9/font.css
@@ -0,0 +1,18 @@
+/* latin-ext */
+@font-face {
+  font-family: 'Courier Prime';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(u-450q2lgwslOqpF_6gQ8kELaw9pWt_-.woff2) format('woff2');
+  unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Courier Prime';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(u-450q2lgwslOqpF_6gQ8kELawFpWg.woff2) format('woff2');
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diff --git a/docs/deps/Roboto-0.4.9/font.css b/docs/deps/Roboto-0.4.9/font.css
new file mode 100644
index 0000000..fd77771
--- /dev/null
+++ b/docs/deps/Roboto-0.4.9/font.css
@@ -0,0 +1,63 @@
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Roboto';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(KFOmCnqEu92Fr1Mu72xKOzY.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Roboto';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(KFOmCnqEu92Fr1Mu5mxKOzY.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Roboto';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(KFOmCnqEu92Fr1Mu7mxKOzY.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Roboto';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(KFOmCnqEu92Fr1Mu4WxKOzY.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Roboto';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(KFOmCnqEu92Fr1Mu7WxKOzY.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Roboto';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(KFOmCnqEu92Fr1Mu7GxKOzY.woff2) format('woff2');
+  unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Roboto';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(KFOmCnqEu92Fr1Mu4mxK.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
diff --git a/docs/deps/bootstrap-5.3.1/bootstrap.bundle.min.js b/docs/deps/bootstrap-5.3.1/bootstrap.bundle.min.js
new file mode 100644
index 0000000..e8f21f7
--- /dev/null
+++ b/docs/deps/bootstrap-5.3.1/bootstrap.bundle.min.js
@@ -0,0 +1,7 @@
+/*!
+  * Bootstrap v5.3.1 (https://getbootstrap.com/)
+  * Copyright 2011-2023 The Bootstrap Authors (https://github.com/twbs/bootstrap/graphs/contributors)
+  * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)
+  */
+!function(t,e){"object"==typeof exports&&"undefined"!=typeof module?module.exports=e():"function"==typeof define&&define.amd?define(e):(t="undefined"!=typeof globalThis?globalThis:t||self).bootstrap=e()}(this,(function(){"use strict";const t=new Map,e={set(e,i,n){t.has(e)||t.set(e,new Map);const s=t.get(e);s.has(i)||0===s.size?s.set(i,n):console.error(`Bootstrap doesn't allow more than one instance per element. 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this._getItems().indexOf(t)}_setActiveIndicatorElement(t){if(!this._indicatorsElement)return;const e=z.findOne(wt,this._indicatorsElement);e.classList.remove(yt),e.removeAttribute("aria-current");const i=z.findOne(`[data-bs-slide-to="${t}"]`,this._indicatorsElement);i&&(i.classList.add(yt),i.setAttribute("aria-current","true"))}_updateInterval(){const t=this._activeElement||this._getActive();if(!t)return;const e=Number.parseInt(t.getAttribute("data-bs-interval"),10);this._config.interval=e||this._config.defaultInterval}_slide(t,e=null){if(this._isSliding)return;const i=this._getActive(),n=t===at,s=e||b(this._getItems(),i,n,this._config.wrap);if(s===i)return;const o=this._getItemIndex(s),r=e=>N.trigger(this._element,e,{relatedTarget:s,direction:this._orderToDirection(t),from:this._getItemIndex(i),to:o});if(r(dt).defaultPrevented)return;if(!i||!s)return;const a=Boolean(this._interval);this.pause(),this._isSliding=!0,this._setActiveIndicatorElement(o),this._activeElement=s;const l=n?"carousel-item-start":"carousel-item-end",c=n?"carousel-item-next":"carousel-item-prev";s.classList.add(c),d(s),i.classList.add(l),s.classList.add(l),this._queueCallback((()=>{s.classList.remove(l,c),s.classList.add(yt),i.classList.remove(yt,c,l),this._isSliding=!1,r(ut)}),i,this._isAnimated()),a&&this.cycle()}_isAnimated(){return this._element.classList.contains("slide")}_getActive(){return z.findOne(Et,this._element)}_getItems(){return z.find(At,this._element)}_clearInterval(){this._interval&&(clearInterval(this._interval),this._interval=null)}_directionToOrder(t){return p()?t===ct?lt:at:t===ct?at:lt}_orderToDirection(t){return p()?t===lt?ct:ht:t===lt?ht:ct}static jQueryInterface(t){return this.each((function(){const e=xt.getOrCreateInstance(this,t);if("number"!=typeof t){if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t]()}}else e.to(t)}))}}N.on(document,bt,"[data-bs-slide], 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i=`scroll${e[0].toUpperCase()+e.slice(1)}`;this._queueCallback((()=>{this._isTransitioning=!1,this._element.classList.remove(Mt),this._element.classList.add(Pt,Nt),this._element.style[e]="",N.trigger(this._element,St)}),this._element,!0),this._element.style[e]=`${this._element[i]}px`}hide(){if(this._isTransitioning||!this._isShown())return;if(N.trigger(this._element,Dt).defaultPrevented)return;const t=this._getDimension();this._element.style[t]=`${this._element.getBoundingClientRect()[t]}px`,d(this._element),this._element.classList.add(Mt),this._element.classList.remove(Pt,Nt);for(const t of this._triggerArray){const e=z.getElementFromSelector(t);e&&!this._isShown(e)&&this._addAriaAndCollapsedClass([t],!1)}this._isTransitioning=!0,this._element.style[t]="",this._queueCallback((()=>{this._isTransitioning=!1,this._element.classList.remove(Mt),this._element.classList.add(Pt),N.trigger(this._element,$t)}),this._element,!0)}_isShown(t=this._element){return 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s(t){i.add(t.name),[].concat(t.requires||[],t.requiresIfExists||[]).forEach((function(t){if(!i.has(t)){var n=e.get(t);n&&s(n)}})),n.push(t)}return t.forEach((function(t){e.set(t.name,t)})),t.forEach((function(t){i.has(t.name)||s(t)})),n}var fi={placement:"bottom",modifiers:[],strategy:"absolute"};function pi(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];return!e.some((function(t){return!(t&&"function"==typeof t.getBoundingClientRect)}))}function mi(t){void 0===t&&(t={});var e=t,i=e.defaultModifiers,n=void 0===i?[]:i,s=e.defaultOptions,o=void 0===s?fi:s;return function(t,e,i){void 0===i&&(i=o);var s,r,a={placement:"bottom",orderedModifiers:[],options:Object.assign({},fi,o),modifiersData:{},elements:{reference:t,popper:e},attributes:{},styles:{}},l=[],c=!1,h={state:a,setOptions:function(i){var s="function"==typeof 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vi=Object.freeze(Object.defineProperty({__proto__:null,afterMain:ae,afterRead:se,afterWrite:he,applyStyles:_e,arrow:je,auto:Kt,basePlacements:Qt,beforeMain:oe,beforeRead:ie,beforeWrite:le,bottom:Rt,clippingParents:Ut,computeStyles:Be,createPopper:bi,createPopperBase:gi,createPopperLite:_i,detectOverflow:ii,end:Yt,eventListeners:Re,flip:si,hide:ai,left:Vt,main:re,modifierPhases:de,offset:li,placements:ee,popper:Jt,popperGenerator:mi,popperOffsets:ci,preventOverflow:hi,read:ne,reference:Zt,right:qt,start:Xt,top:zt,variationPlacements:te,viewport:Gt,write:ce},Symbol.toStringTag,{value:"Module"})),yi="dropdown",wi=".bs.dropdown",Ai=".data-api",Ei="ArrowUp",Ti="ArrowDown",Ci=`hide${wi}`,Oi=`hidden${wi}`,xi=`show${wi}`,ki=`shown${wi}`,Li=`click${wi}${Ai}`,Si=`keydown${wi}${Ai}`,Di=`keyup${wi}${Ai}`,$i="show",Ii='[data-bs-toggle="dropdown"]:not(.disabled):not(:disabled)',Ni=`${Ii}.${$i}`,Pi=".dropdown-menu",Mi=p()?"top-end":"top-start",ji=p()?"top-start":"top-end",Fi=p()?"bottom-end":"bottom-start",Hi=p()?"bottom-start":"bottom-end",Wi=p()?"left-start":"right-start",Bi=p()?"right-start":"left-start",zi={autoClose:!0,boundary:"clippingParents",display:"dynamic",offset:[0,2],popperConfig:null,reference:"toggle"},Ri={autoClose:"(boolean|string)",boundary:"(string|element)",display:"string",offset:"(array|string|function)",popperConfig:"(null|object|function)",reference:"(string|element|object)"};class qi extends W{constructor(t,e){super(t,e),this._popper=null,this._parent=this._element.parentNode,this._menu=z.next(this._element,Pi)[0]||z.prev(this._element,Pi)[0]||z.findOne(Pi,this._parent),this._inNavbar=this._detectNavbar()}static get Default(){return zi}static get DefaultType(){return Ri}static get NAME(){return yi}toggle(){return this._isShown()?this.hide():this.show()}show(){if(l(this._element)||this._isShown())return;const t={relatedTarget:this._element};if(!N.trigger(this._element,xi,t).defaultPrevented){if(this._createPopper(),"ontouchstart"in document.documentElement&&!this._parent.closest(".navbar-nav"))for(const t of[].concat(...document.body.children))N.on(t,"mouseover",h);this._element.focus(),this._element.setAttribute("aria-expanded",!0),this._menu.classList.add($i),this._element.classList.add($i),N.trigger(this._element,ki,t)}}hide(){if(l(this._element)||!this._isShown())return;const t={relatedTarget:this._element};this._completeHide(t)}dispose(){this._popper&&this._popper.destroy(),super.dispose()}update(){this._inNavbar=this._detectNavbar(),this._popper&&this._popper.update()}_completeHide(t){if(!N.trigger(this._element,Ci,t).defaultPrevented){if("ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.off(t,"mouseover",h);this._popper&&this._popper.destroy(),this._menu.classList.remove($i),this._element.classList.remove($i),this._element.setAttribute("aria-expanded","false"),F.removeDataAttribute(this._menu,"popper"),N.trigger(this._element,Oi,t)}}_getConfig(t){if("object"==typeof(t=super._getConfig(t)).reference&&!o(t.reference)&&"function"!=typeof t.reference.getBoundingClientRect)throw new TypeError(`${yi.toUpperCase()}: Option "reference" provided type "object" without a required "getBoundingClientRect" method.`);return t}_createPopper(){if(void 0===vi)throw new TypeError("Bootstrap's dropdowns require Popper 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t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return(this._inNavbar||"static"===this._config.display)&&(F.setDataAttribute(this._menu,"popper","static"),t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,...g(this._config.popperConfig,[t])}}_selectMenuItem({key:t,target:e}){const i=z.find(".dropdown-menu .dropdown-item:not(.disabled):not(:disabled)",this._menu).filter((t=>a(t)));i.length&&b(i,e,t===Ti,!i.includes(e)).focus()}static jQueryInterface(t){return this.each((function(){const e=qi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}static clearMenus(t){if(2===t.button||"keyup"===t.type&&"Tab"!==t.key)return;const e=z.find(Ni);for(const i of e){const e=qi.getInstance(i);if(!e||!1===e._config.autoClose)continue;const n=t.composedPath(),s=n.includes(e._menu);if(n.includes(e._element)||"inside"===e._config.autoClose&&!s||"outside"===e._config.autoClose&&s)continue;if(e._menu.contains(t.target)&&("keyup"===t.type&&"Tab"===t.key||/input|select|option|textarea|form/i.test(t.target.tagName)))continue;const o={relatedTarget:e._element};"click"===t.type&&(o.clickEvent=t),e._completeHide(o)}}static dataApiKeydownHandler(t){const e=/input|textarea/i.test(t.target.tagName),i="Escape"===t.key,n=[Ei,Ti].includes(t.key);if(!n&&!i)return;if(e&&!i)return;t.preventDefault();const s=this.matches(Ii)?this:z.prev(this,Ii)[0]||z.next(this,Ii)[0]||z.findOne(Ii,t.delegateTarget.parentNode),o=qi.getOrCreateInstance(s);if(n)return t.stopPropagation(),o.show(),void o._selectMenuItem(t);o._isShown()&&(t.stopPropagation(),o.hide(),s.focus())}}N.on(document,Si,Ii,qi.dataApiKeydownHandler),N.on(document,Si,Pi,qi.dataApiKeydownHandler),N.on(document,Li,qi.clearMenus),N.on(document,Di,qi.clearMenus),N.on(document,Li,Ii,(function(t){t.preventDefault(),qi.getOrCreateInstance(this).toggle()})),m(qi);const Vi="backdrop",Ki="show",Qi=`mousedown.bs.${Vi}`,Xi={className:"modal-backdrop",clickCallback:null,isAnimated:!1,isVisible:!0,rootElement:"body"},Yi={className:"string",clickCallback:"(function|null)",isAnimated:"boolean",isVisible:"boolean",rootElement:"(element|string)"};class Ui extends H{constructor(t){super(),this._config=this._getConfig(t),this._isAppended=!1,this._element=null}static get Default(){return Xi}static get DefaultType(){return Yi}static get NAME(){return Vi}show(t){if(!this._config.isVisible)return void g(t);this._append();const e=this._getElement();this._config.isAnimated&&d(e),e.classList.add(Ki),this._emulateAnimation((()=>{g(t)}))}hide(t){this._config.isVisible?(this._getElement().classList.remove(Ki),this._emulateAnimation((()=>{this.dispose(),g(t)}))):g(t)}dispose(){this._isAppended&&(N.off(this._element,Qi),this._element.remove(),this._isAppended=!1)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_configAfterMerge(t){return t.rootElement=r(t.rootElement),t}_append(){if(this._isAppended)return;const t=this._getElement();this._config.rootElement.append(t),N.on(t,Qi,(()=>{g(this._config.clickCallback)})),this._isAppended=!0}_emulateAnimation(t){_(t,this._getElement(),this._config.isAnimated)}}const Gi=".bs.focustrap",Ji=`focusin${Gi}`,Zi=`keydown.tab${Gi}`,tn="backward",en={autofocus:!0,trapElement:null},nn={autofocus:"boolean",trapElement:"element"};class sn extends H{constructor(t){super(),this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}static get Default(){return en}static get DefaultType(){return nn}static get NAME(){return"focustrap"}activate(){this._isActive||(this._config.autofocus&&this._config.trapElement.focus(),N.off(document,Gi),N.on(document,Ji,(t=>this._handleFocusin(t))),N.on(document,Zi,(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,N.off(document,Gi))}_handleFocusin(t){const{trapElement:e}=this._config;if(t.target===document||t.target===e||e.contains(t.target))return;const i=z.focusableChildren(e);0===i.length?e.focus():this._lastTabNavDirection===tn?i[i.length-1].focus():i[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?tn:"forward")}}const on=".fixed-top, .fixed-bottom, .is-fixed, .sticky-top",rn=".sticky-top",an="padding-right",ln="margin-right";class cn{constructor(){this._element=document.body}getWidth(){const t=document.documentElement.clientWidth;return Math.abs(window.innerWidth-t)}hide(){const t=this.getWidth();this._disableOverFlow(),this._setElementAttributes(this._element,an,(e=>e+t)),this._setElementAttributes(on,an,(e=>e+t)),this._setElementAttributes(rn,ln,(e=>e-t))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,an),this._resetElementAttributes(on,an),this._resetElementAttributes(rn,ln)}isOverflowing(){return this.getWidth()>0}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t).getPropertyValue(e);t.style.setProperty(e,`${i(Number.parseFloat(s))}px`)}))}_saveInitialAttribute(t,e){const i=t.style.getPropertyValue(e);i&&F.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=F.getDataAttribute(t,e);null!==i?(F.removeDataAttribute(t,e),t.style.setProperty(e,i)):t.style.removeProperty(e)}))}_applyManipulationCallback(t,e){if(o(t))e(t);else for(const i of z.find(t,this._element))e(i)}}const hn=".bs.modal",dn=`hide${hn}`,un=`hidePrevented${hn}`,fn=`hidden${hn}`,pn=`show${hn}`,mn=`shown${hn}`,gn=`resize${hn}`,_n=`click.dismiss${hn}`,bn=`mousedown.dismiss${hn}`,vn=`keydown.dismiss${hn}`,yn=`click${hn}.data-api`,wn="modal-open",An="show",En="modal-static",Tn={backdrop:!0,focus:!0,keyboard:!0},Cn={backdrop:"(boolean|string)",focus:"boolean",keyboard:"boolean"};class On extends W{constructor(t,e){super(t,e),this._dialog=z.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._isTransitioning=!1,this._scrollBar=new cn,this._addEventListeners()}static get Default(){return Tn}static get DefaultType(){return Cn}static get NAME(){return"modal"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||N.trigger(this._element,pn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isTransitioning=!0,this._scrollBar.hide(),document.body.classList.add(wn),this._adjustDialog(),this._backdrop.show((()=>this._showElement(t))))}hide(){this._isShown&&!this._isTransitioning&&(N.trigger(this._element,dn).defaultPrevented||(this._isShown=!1,this._isTransitioning=!0,this._focustrap.deactivate(),this._element.classList.remove(An),this._queueCallback((()=>this._hideModal()),this._element,this._isAnimated())))}dispose(){N.off(window,hn),N.off(this._dialog,hn),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new Ui({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_showElement(t){document.body.contains(this._element)||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0;const e=z.findOne(".modal-body",this._dialog);e&&(e.scrollTop=0),d(this._element),this._element.classList.add(An),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,N.trigger(this._element,mn,{relatedTarget:t})}),this._dialog,this._isAnimated())}_addEventListeners(){N.on(this._element,vn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():this._triggerBackdropTransition())})),N.on(window,gn,(()=>{this._isShown&&!this._isTransitioning&&this._adjustDialog()})),N.on(this._element,bn,(t=>{N.one(this._element,_n,(e=>{this._element===t.target&&this._element===e.target&&("static"!==this._config.backdrop?this._config.backdrop&&this.hide():this._triggerBackdropTransition())}))}))}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(wn),this._resetAdjustments(),this._scrollBar.reset(),N.trigger(this._element,fn)}))}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(N.trigger(this._element,un).defaultPrevented)return;const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._element.style.overflowY;"hidden"===e||this._element.classList.contains(En)||(t||(this._element.style.overflowY="hidden"),this._element.classList.add(En),this._queueCallback((()=>{this._element.classList.remove(En),this._queueCallback((()=>{this._element.style.overflowY=e}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;if(i&&!t){const t=p()?"paddingLeft":"paddingRight";this._element.style[t]=`${e}px`}if(!i&&t){const t=p()?"paddingRight":"paddingLeft";this._element.style[t]=`${e}px`}}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=On.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}N.on(document,yn,'[data-bs-toggle="modal"]',(function(t){const e=z.getElementFromSelector(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),N.one(e,pn,(t=>{t.defaultPrevented||N.one(e,fn,(()=>{a(this)&&this.focus()}))}));const i=z.findOne(".modal.show");i&&On.getInstance(i).hide(),On.getOrCreateInstance(e).toggle(this)})),R(On),m(On);const xn=".bs.offcanvas",kn=".data-api",Ln=`load${xn}${kn}`,Sn="show",Dn="showing",$n="hiding",In=".offcanvas.show",Nn=`show${xn}`,Pn=`shown${xn}`,Mn=`hide${xn}`,jn=`hidePrevented${xn}`,Fn=`hidden${xn}`,Hn=`resize${xn}`,Wn=`click${xn}${kn}`,Bn=`keydown.dismiss${xn}`,zn={backdrop:!0,keyboard:!0,scroll:!1},Rn={backdrop:"(boolean|string)",keyboard:"boolean",scroll:"boolean"};class qn extends W{constructor(t,e){super(t,e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get Default(){return zn}static get DefaultType(){return Rn}static get NAME(){return"offcanvas"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||N.trigger(this._element,Nn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._backdrop.show(),this._config.scroll||(new cn).hide(),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add(Dn),this._queueCallback((()=>{this._config.scroll&&!this._config.backdrop||this._focustrap.activate(),this._element.classList.add(Sn),this._element.classList.remove(Dn),N.trigger(this._element,Pn,{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(N.trigger(this._element,Mn).defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.add($n),this._backdrop.hide(),this._queueCallback((()=>{this._element.classList.remove(Sn,$n),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._config.scroll||(new cn).reset(),N.trigger(this._element,Fn)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_initializeBackDrop(){const t=Boolean(this._config.backdrop);return new Ui({className:"offcanvas-backdrop",isVisible:t,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:t?()=>{"static"!==this._config.backdrop?this.hide():N.trigger(this._element,jn)}:null})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_addEventListeners(){N.on(this._element,Bn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():N.trigger(this._element,jn))}))}static jQueryInterface(t){return this.each((function(){const e=qn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}N.on(document,Wn,'[data-bs-toggle="offcanvas"]',(function(t){const e=z.getElementFromSelector(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),l(this))return;N.one(e,Fn,(()=>{a(this)&&this.focus()}));const i=z.findOne(In);i&&i!==e&&qn.getInstance(i).hide(),qn.getOrCreateInstance(e).toggle(this)})),N.on(window,Ln,(()=>{for(const t of z.find(In))qn.getOrCreateInstance(t).show()})),N.on(window,Hn,(()=>{for(const t of z.find("[aria-modal][class*=show][class*=offcanvas-]"))"fixed"!==getComputedStyle(t).position&&qn.getOrCreateInstance(t).hide()})),R(qn),m(qn);const Vn={"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},Kn=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Qn=/^(?!javascript:)(?:[a-z0-9+.-]+:|[^&:/?#]*(?:[/?#]|$))/i,Xn=(t,e)=>{const i=t.nodeName.toLowerCase();return e.includes(i)?!Kn.has(i)||Boolean(Qn.test(t.nodeValue)):e.filter((t=>t instanceof RegExp)).some((t=>t.test(i)))},Yn={allowList:Vn,content:{},extraClass:"",html:!1,sanitize:!0,sanitizeFn:null,template:"<div></div>"},Un={allowList:"object",content:"object",extraClass:"(string|function)",html:"boolean",sanitize:"boolean",sanitizeFn:"(null|function)",template:"string"},Gn={entry:"(string|element|function|null)",selector:"(string|element)"};class Jn extends H{constructor(t){super(),this._config=this._getConfig(t)}static get Default(){return Yn}static get DefaultType(){return Un}static get NAME(){return"TemplateFactory"}getContent(){return Object.values(this._config.content).map((t=>this._resolvePossibleFunction(t))).filter(Boolean)}hasContent(){return this.getContent().length>0}changeContent(t){return this._checkContent(t),this._config.content={...this._config.content,...t},this}toHtml(){const t=document.createElement("div");t.innerHTML=this._maybeSanitize(this._config.template);for(const[e,i]of Object.entries(this._config.content))this._setContent(t,i,e);const e=t.children[0],i=this._resolvePossibleFunction(this._config.extraClass);return i&&e.classList.add(...i.split(" ")),e}_typeCheckConfig(t){super._typeCheckConfig(t),this._checkContent(t.content)}_checkContent(t){for(const[e,i]of Object.entries(t))super._typeCheckConfig({selector:e,entry:i},Gn)}_setContent(t,e,i){const n=z.findOne(i,t);n&&((e=this._resolvePossibleFunction(e))?o(e)?this._putElementInTemplate(r(e),n):this._config.html?n.innerHTML=this._maybeSanitize(e):n.textContent=e:n.remove())}_maybeSanitize(t){return this._config.sanitize?function(t,e,i){if(!t.length)return t;if(i&&"function"==typeof i)return i(t);const n=(new window.DOMParser).parseFromString(t,"text/html"),s=[].concat(...n.body.querySelectorAll("*"));for(const t of s){const i=t.nodeName.toLowerCase();if(!Object.keys(e).includes(i)){t.remove();continue}const n=[].concat(...t.attributes),s=[].concat(e["*"]||[],e[i]||[]);for(const e of n)Xn(e,s)||t.removeAttribute(e.nodeName)}return n.body.innerHTML}(t,this._config.allowList,this._config.sanitizeFn):t}_resolvePossibleFunction(t){return g(t,[this])}_putElementInTemplate(t,e){if(this._config.html)return e.innerHTML="",void e.append(t);e.textContent=t.textContent}}const Zn=new Set(["sanitize","allowList","sanitizeFn"]),ts="fade",es="show",is=".modal",ns="hide.bs.modal",ss="hover",os="focus",rs={AUTO:"auto",TOP:"top",RIGHT:p()?"left":"right",BOTTOM:"bottom",LEFT:p()?"right":"left"},as={allowList:Vn,animation:!0,boundary:"clippingParents",container:!1,customClass:"",delay:0,fallbackPlacements:["top","right","bottom","left"],html:!1,offset:[0,6],placement:"top",popperConfig:null,sanitize:!0,sanitizeFn:null,selector:!1,template:'<div class="tooltip" role="tooltip"><div class="tooltip-arrow"></div><div class="tooltip-inner"></div></div>',title:"",trigger:"hover focus"},ls={allowList:"object",animation:"boolean",boundary:"(string|element)",container:"(string|element|boolean)",customClass:"(string|function)",delay:"(number|object)",fallbackPlacements:"array",html:"boolean",offset:"(array|string|function)",placement:"(string|function)",popperConfig:"(null|object|function)",sanitize:"boolean",sanitizeFn:"(null|function)",selector:"(string|boolean)",template:"string",title:"(string|element|function)",trigger:"string"};class cs extends W{constructor(t,e){if(void 0===vi)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t,e),this._isEnabled=!0,this._timeout=0,this._isHovered=null,this._activeTrigger={},this._popper=null,this._templateFactory=null,this._newContent=null,this.tip=null,this._setListeners(),this._config.selector||this._fixTitle()}static get Default(){return as}static get DefaultType(){return ls}static get NAME(){return"tooltip"}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(){this._isEnabled&&(this._activeTrigger.click=!this._activeTrigger.click,this._isShown()?this._leave():this._enter())}dispose(){clearTimeout(this._timeout),N.off(this._element.closest(is),ns,this._hideModalHandler),this._element.getAttribute("data-bs-original-title")&&this._element.setAttribute("title",this._element.getAttribute("data-bs-original-title")),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this._isWithContent()||!this._isEnabled)return;const t=N.trigger(this._element,this.constructor.eventName("show")),e=(c(this._element)||this._element.ownerDocument.documentElement).contains(this._element);if(t.defaultPrevented||!e)return;this._disposePopper();const i=this._getTipElement();this._element.setAttribute("aria-describedby",i.getAttribute("id"));const{container:n}=this._config;if(this._element.ownerDocument.documentElement.contains(this.tip)||(n.append(i),N.trigger(this._element,this.constructor.eventName("inserted"))),this._popper=this._createPopper(i),i.classList.add(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.on(t,"mouseover",h);this._queueCallback((()=>{N.trigger(this._element,this.constructor.eventName("shown")),!1===this._isHovered&&this._leave(),this._isHovered=!1}),this.tip,this._isAnimated())}hide(){if(this._isShown()&&!N.trigger(this._element,this.constructor.eventName("hide")).defaultPrevented){if(this._getTipElement().classList.remove(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.off(t,"mouseover",h);this._activeTrigger.click=!1,this._activeTrigger[os]=!1,this._activeTrigger[ss]=!1,this._isHovered=null,this._queueCallback((()=>{this._isWithActiveTrigger()||(this._isHovered||this._disposePopper(),this._element.removeAttribute("aria-describedby"),N.trigger(this._element,this.constructor.eventName("hidden")))}),this.tip,this._isAnimated())}}update(){this._popper&&this._popper.update()}_isWithContent(){return Boolean(this._getTitle())}_getTipElement(){return this.tip||(this.tip=this._createTipElement(this._newContent||this._getContentForTemplate())),this.tip}_createTipElement(t){const e=this._getTemplateFactory(t).toHtml();if(!e)return null;e.classList.remove(ts,es),e.classList.add(`bs-${this.constructor.NAME}-auto`);const i=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME).toString();return e.setAttribute("id",i),this._isAnimated()&&e.classList.add(ts),e}setContent(t){this._newContent=t,this._isShown()&&(this._disposePopper(),this.show())}_getTemplateFactory(t){return this._templateFactory?this._templateFactory.changeContent(t):this._templateFactory=new Jn({...this._config,content:t,extraClass:this._resolvePossibleFunction(this._config.customClass)}),this._templateFactory}_getContentForTemplate(){return{".tooltip-inner":this._getTitle()}}_getTitle(){return this._resolvePossibleFunction(this._config.title)||this._element.getAttribute("data-bs-original-title")}_initializeOnDelegatedTarget(t){return this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_isAnimated(){return this._config.animation||this.tip&&this.tip.classList.contains(ts)}_isShown(){return this.tip&&this.tip.classList.contains(es)}_createPopper(t){const e=g(this._config.placement,[this,t,this._element]),i=rs[e.toUpperCase()];return 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object[0] : object\n  }\n\n  if (typeof object === 'string' && object.length > 0) {\n    return document.querySelector(parseSelector(object))\n  }\n\n  return null\n}\n\nconst isVisible = element => {\n  if (!isElement(element) || element.getClientRects().length === 0) {\n    return false\n  }\n\n  const elementIsVisible = getComputedStyle(element).getPropertyValue('visibility') === 'visible'\n  // Handle `details` element as its content may falsie appear visible when it is closed\n  const closedDetails = element.closest('details:not([open])')\n\n  if (!closedDetails) {\n    return elementIsVisible\n  }\n\n  if (closedDetails !== element) {\n    const summary = element.closest('summary')\n    if (summary && summary.parentNode !== closedDetails) {\n      return false\n    }\n\n    if (summary === null) {\n      return false\n    }\n  }\n\n  return elementIsVisible\n}\n\nconst isDisabled = element => {\n  if (!element || element.nodeType !== Node.ELEMENT_NODE) {\n    return true\n  }\n\n  if (element.classList.contains('disabled')) {\n    return true\n  }\n\n  if (typeof element.disabled !== 'undefined') {\n    return element.disabled\n  }\n\n  return element.hasAttribute('disabled') && element.getAttribute('disabled') !== 'false'\n}\n\nconst findShadowRoot = element => {\n  if (!document.documentElement.attachShadow) {\n    return null\n  }\n\n  // Can find the shadow root otherwise it'll return the document\n  if (typeof element.getRootNode === 'function') {\n    const root = element.getRootNode()\n    return root instanceof ShadowRoot ? root : null\n  }\n\n  if (element instanceof ShadowRoot) {\n    return element\n  }\n\n  // when we don't find a shadow root\n  if (!element.parentNode) {\n    return null\n  }\n\n  return findShadowRoot(element.parentNode)\n}\n\nconst noop = () => {}\n\n/**\n * Trick to restart an element's animation\n *\n * @param {HTMLElement} element\n * @return void\n *\n * @see https://www.charistheo.io/blog/2021/02/restart-a-css-animation-with-javascript/#restarting-a-css-animation\n */\nconst reflow = element => {\n  element.offsetHeight // eslint-disable-line no-unused-expressions\n}\n\nconst getjQuery = () => {\n  if (window.jQuery && !document.body.hasAttribute('data-bs-no-jquery')) {\n    return window.jQuery\n  }\n\n  return null\n}\n\nconst DOMContentLoadedCallbacks = []\n\nconst onDOMContentLoaded = callback => {\n  if (document.readyState === 'loading') {\n    // add listener on the first call when the document is in loading state\n    if (!DOMContentLoadedCallbacks.length) {\n      document.addEventListener('DOMContentLoaded', () => {\n        for (const callback of DOMContentLoadedCallbacks) {\n          callback()\n        }\n      })\n    }\n\n    DOMContentLoadedCallbacks.push(callback)\n  } else {\n    callback()\n  }\n}\n\nconst isRTL = () => document.documentElement.dir === 'rtl'\n\nconst defineJQueryPlugin = plugin => {\n  onDOMContentLoaded(() => {\n    const $ = getjQuery()\n    /* istanbul ignore if */\n    if ($) {\n      const name = plugin.NAME\n      const JQUERY_NO_CONFLICT = $.fn[name]\n      $.fn[name] = plugin.jQueryInterface\n      $.fn[name].Constructor = plugin\n      $.fn[name].noConflict = () => {\n        $.fn[name] = JQUERY_NO_CONFLICT\n        return plugin.jQueryInterface\n      }\n    }\n  })\n}\n\nconst execute = (possibleCallback, args = [], defaultValue = possibleCallback) => {\n  return typeof possibleCallback === 'function' ? possibleCallback(...args) : defaultValue\n}\n\nconst executeAfterTransition = (callback, transitionElement, waitForTransition = true) => {\n  if (!waitForTransition) {\n    execute(callback)\n    return\n  }\n\n  const durationPadding = 5\n  const emulatedDuration = getTransitionDurationFromElement(transitionElement) + durationPadding\n\n  let called = false\n\n  const handler = ({ target }) => {\n    if (target !== transitionElement) {\n      return\n    }\n\n    called = true\n    transitionElement.removeEventListener(TRANSITION_END, handler)\n    execute(callback)\n  }\n\n  transitionElement.addEventListener(TRANSITION_END, handler)\n  setTimeout(() => {\n    if (!called) {\n      triggerTransitionEnd(transitionElement)\n    }\n  }, emulatedDuration)\n}\n\n/**\n * Return the previous/next element of a list.\n *\n * @param {array} list    The list of elements\n * @param activeElement   The active element\n * @param shouldGetNext   Choose to get next or previous element\n * @param isCycleAllowed\n * @return {Element|elem} The proper element\n */\nconst getNextActiveElement = (list, activeElement, shouldGetNext, isCycleAllowed) => {\n  const listLength = list.length\n  let index = list.indexOf(activeElement)\n\n  // if the element does not exist in the list return an element\n  // depending on the direction and if cycle is allowed\n  if (index === -1) {\n    return !shouldGetNext && isCycleAllowed ? list[listLength - 1] : list[0]\n  }\n\n  index += shouldGetNext ? 1 : -1\n\n  if (isCycleAllowed) {\n    index = (index + listLength) % listLength\n  }\n\n  return list[Math.max(0, Math.min(index, listLength - 1))]\n}\n\nexport {\n  defineJQueryPlugin,\n  execute,\n  executeAfterTransition,\n  findShadowRoot,\n  getElement,\n  getjQuery,\n  getNextActiveElement,\n  getTransitionDurationFromElement,\n  getUID,\n  isDisabled,\n  isElement,\n  isRTL,\n  isVisible,\n  noop,\n  onDOMContentLoaded,\n  parseSelector,\n  reflow,\n  triggerTransitionEnd,\n  toType\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap dom/event-handler.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { getjQuery } from '../util/index.js'\n\n/**\n * Constants\n */\n\nconst namespaceRegex = /[^.]*(?=\\..*)\\.|.*/\nconst stripNameRegex = /\\..*/\nconst stripUidRegex = /::\\d+$/\nconst eventRegistry = {} // Events storage\nlet uidEvent = 1\nconst customEvents = {\n  mouseenter: 'mouseover',\n  mouseleave: 'mouseout'\n}\n\nconst nativeEvents = new Set([\n  'click',\n  'dblclick',\n  'mouseup',\n  'mousedown',\n  'contextmenu',\n  'mousewheel',\n  'DOMMouseScroll',\n  'mouseover',\n  'mouseout',\n  'mousemove',\n  'selectstart',\n  'selectend',\n  'keydown',\n  'keypress',\n  'keyup',\n  'orientationchange',\n  'touchstart',\n  'touchmove',\n  'touchend',\n  'touchcancel',\n  'pointerdown',\n  'pointermove',\n  'pointerup',\n  'pointerleave',\n  'pointercancel',\n  'gesturestart',\n  'gesturechange',\n  'gestureend',\n  'focus',\n  'blur',\n  'change',\n  'reset',\n  'select',\n  'submit',\n  'focusin',\n  'focusout',\n  'load',\n  'unload',\n  'beforeunload',\n  'resize',\n  'move',\n  'DOMContentLoaded',\n  'readystatechange',\n  'error',\n  'abort',\n  'scroll'\n])\n\n/**\n * Private methods\n */\n\nfunction makeEventUid(element, uid) {\n  return (uid && `${uid}::${uidEvent++}`) || element.uidEvent || uidEvent++\n}\n\nfunction getElementEvents(element) {\n  const uid = makeEventUid(element)\n\n  element.uidEvent = uid\n  eventRegistry[uid] = eventRegistry[uid] || {}\n\n  return eventRegistry[uid]\n}\n\nfunction bootstrapHandler(element, fn) {\n  return function handler(event) {\n    hydrateObj(event, { delegateTarget: element })\n\n    if (handler.oneOff) {\n      EventHandler.off(element, event.type, fn)\n    }\n\n    return fn.apply(element, [event])\n  }\n}\n\nfunction bootstrapDelegationHandler(element, selector, fn) {\n  return function handler(event) {\n    const domElements = element.querySelectorAll(selector)\n\n    for (let { target } = event; target && target !== this; target = target.parentNode) {\n      for (const domElement of domElements) {\n        if (domElement !== target) {\n          continue\n        }\n\n        hydrateObj(event, { delegateTarget: target })\n\n        if (handler.oneOff) {\n          EventHandler.off(element, event.type, selector, fn)\n        }\n\n        return fn.apply(target, [event])\n      }\n    }\n  }\n}\n\nfunction findHandler(events, callable, delegationSelector = null) {\n  return Object.values(events)\n    .find(event => event.callable === callable && event.delegationSelector === delegationSelector)\n}\n\nfunction normalizeParameters(originalTypeEvent, handler, delegationFunction) {\n  const isDelegated = typeof handler === 'string'\n  // TODO: tooltip passes `false` instead of selector, so we need to check\n  const callable = isDelegated ? delegationFunction : (handler || delegationFunction)\n  let typeEvent = getTypeEvent(originalTypeEvent)\n\n  if (!nativeEvents.has(typeEvent)) {\n    typeEvent = originalTypeEvent\n  }\n\n  return [isDelegated, callable, typeEvent]\n}\n\nfunction addHandler(element, originalTypeEvent, handler, delegationFunction, oneOff) {\n  if (typeof originalTypeEvent !== 'string' || !element) {\n    return\n  }\n\n  let [isDelegated, callable, typeEvent] = normalizeParameters(originalTypeEvent, handler, delegationFunction)\n\n  // in case of mouseenter or mouseleave wrap the handler within a function that checks for its DOM position\n  // this prevents the handler from being dispatched the same way as mouseover or mouseout does\n  if (originalTypeEvent in customEvents) {\n    const wrapFunction = fn => {\n      return function (event) {\n        if (!event.relatedTarget || (event.relatedTarget !== event.delegateTarget && !event.delegateTarget.contains(event.relatedTarget))) {\n          return fn.call(this, event)\n        }\n      }\n    }\n\n    callable = wrapFunction(callable)\n  }\n\n  const events = getElementEvents(element)\n  const handlers = events[typeEvent] || (events[typeEvent] = {})\n  const previousFunction = findHandler(handlers, callable, isDelegated ? handler : null)\n\n  if (previousFunction) {\n    previousFunction.oneOff = previousFunction.oneOff && oneOff\n\n    return\n  }\n\n  const uid = makeEventUid(callable, originalTypeEvent.replace(namespaceRegex, ''))\n  const fn = isDelegated ?\n    bootstrapDelegationHandler(element, handler, callable) :\n    bootstrapHandler(element, callable)\n\n  fn.delegationSelector = isDelegated ? handler : null\n  fn.callable = callable\n  fn.oneOff = oneOff\n  fn.uidEvent = uid\n  handlers[uid] = fn\n\n  element.addEventListener(typeEvent, fn, isDelegated)\n}\n\nfunction removeHandler(element, events, typeEvent, handler, delegationSelector) {\n  const fn = findHandler(events[typeEvent], handler, delegationSelector)\n\n  if (!fn) {\n    return\n  }\n\n  element.removeEventListener(typeEvent, fn, Boolean(delegationSelector))\n  delete events[typeEvent][fn.uidEvent]\n}\n\nfunction removeNamespacedHandlers(element, events, typeEvent, namespace) {\n  const storeElementEvent = events[typeEvent] || {}\n\n  for (const [handlerKey, event] of Object.entries(storeElementEvent)) {\n    if (handlerKey.includes(namespace)) {\n      removeHandler(element, events, typeEvent, event.callable, event.delegationSelector)\n    }\n  }\n}\n\nfunction getTypeEvent(event) {\n  // allow to get the native events from namespaced events ('click.bs.button' --> 'click')\n  event = event.replace(stripNameRegex, '')\n  return customEvents[event] || event\n}\n\nconst EventHandler = {\n  on(element, event, handler, delegationFunction) {\n    addHandler(element, event, handler, delegationFunction, false)\n  },\n\n  one(element, event, handler, delegationFunction) {\n    addHandler(element, event, handler, delegationFunction, true)\n  },\n\n  off(element, originalTypeEvent, handler, delegationFunction) {\n    if (typeof originalTypeEvent !== 'string' || !element) {\n      return\n    }\n\n    const [isDelegated, callable, typeEvent] = normalizeParameters(originalTypeEvent, handler, delegationFunction)\n    const inNamespace = typeEvent !== originalTypeEvent\n    const events = getElementEvents(element)\n    const storeElementEvent = events[typeEvent] || {}\n    const isNamespace = originalTypeEvent.startsWith('.')\n\n    if (typeof callable !== 'undefined') {\n      // Simplest case: handler is passed, remove that listener ONLY.\n      if (!Object.keys(storeElementEvent).length) {\n        return\n      }\n\n      removeHandler(element, events, typeEvent, callable, isDelegated ? handler : null)\n      return\n    }\n\n    if (isNamespace) {\n      for (const elementEvent of Object.keys(events)) {\n        removeNamespacedHandlers(element, events, elementEvent, originalTypeEvent.slice(1))\n      }\n    }\n\n    for (const [keyHandlers, event] of Object.entries(storeElementEvent)) {\n      const handlerKey = keyHandlers.replace(stripUidRegex, '')\n\n      if (!inNamespace || originalTypeEvent.includes(handlerKey)) {\n        removeHandler(element, events, typeEvent, event.callable, event.delegationSelector)\n      }\n    }\n  },\n\n  trigger(element, event, args) {\n    if (typeof event !== 'string' || !element) {\n      return null\n    }\n\n    const $ = getjQuery()\n    const typeEvent = getTypeEvent(event)\n    const inNamespace = event !== typeEvent\n\n    let jQueryEvent = null\n    let bubbles = true\n    let nativeDispatch = true\n    let defaultPrevented = false\n\n    if (inNamespace && $) {\n      jQueryEvent = $.Event(event, args)\n\n      $(element).trigger(jQueryEvent)\n      bubbles = !jQueryEvent.isPropagationStopped()\n      nativeDispatch = !jQueryEvent.isImmediatePropagationStopped()\n      defaultPrevented = jQueryEvent.isDefaultPrevented()\n    }\n\n    const evt = hydrateObj(new Event(event, { bubbles, cancelable: true }), args)\n\n    if (defaultPrevented) {\n      evt.preventDefault()\n    }\n\n    if (nativeDispatch) {\n      element.dispatchEvent(evt)\n    }\n\n    if (evt.defaultPrevented && jQueryEvent) {\n      jQueryEvent.preventDefault()\n    }\n\n    return evt\n  }\n}\n\nfunction hydrateObj(obj, meta = {}) {\n  for (const [key, value] of Object.entries(meta)) {\n    try {\n      obj[key] = value\n    } catch {\n      Object.defineProperty(obj, key, {\n        configurable: true,\n        get() {\n          return value\n        }\n      })\n    }\n  }\n\n  return obj\n}\n\nexport default EventHandler\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap dom/manipulator.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nfunction normalizeData(value) {\n  if (value === 'true') {\n    return true\n  }\n\n  if (value === 'false') {\n    return false\n  }\n\n  if (value === Number(value).toString()) {\n    return Number(value)\n  }\n\n  if (value === '' || value === 'null') {\n    return null\n  }\n\n  if (typeof value !== 'string') {\n    return value\n  }\n\n  try {\n    return JSON.parse(decodeURIComponent(value))\n  } catch {\n    return value\n  }\n}\n\nfunction normalizeDataKey(key) {\n  return key.replace(/[A-Z]/g, chr => `-${chr.toLowerCase()}`)\n}\n\nconst Manipulator = {\n  setDataAttribute(element, key, value) {\n    element.setAttribute(`data-bs-${normalizeDataKey(key)}`, value)\n  },\n\n  removeDataAttribute(element, key) {\n    element.removeAttribute(`data-bs-${normalizeDataKey(key)}`)\n  },\n\n  getDataAttributes(element) {\n    if (!element) {\n      return {}\n    }\n\n    const attributes = {}\n    const bsKeys = Object.keys(element.dataset).filter(key => key.startsWith('bs') && !key.startsWith('bsConfig'))\n\n    for (const key of bsKeys) {\n      let pureKey = key.replace(/^bs/, '')\n      pureKey = pureKey.charAt(0).toLowerCase() + pureKey.slice(1, pureKey.length)\n      attributes[pureKey] = normalizeData(element.dataset[key])\n    }\n\n    return attributes\n  },\n\n  getDataAttribute(element, key) {\n    return normalizeData(element.getAttribute(`data-bs-${normalizeDataKey(key)}`))\n  }\n}\n\nexport default Manipulator\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/config.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Manipulator from '../dom/manipulator.js'\nimport { isElement, toType } from './index.js'\n\n/**\n * Class definition\n */\n\nclass Config {\n  // Getters\n  static get Default() {\n    return {}\n  }\n\n  static get DefaultType() {\n    return {}\n  }\n\n  static get NAME() {\n    throw new Error('You have to implement the static method \"NAME\", for each component!')\n  }\n\n  _getConfig(config) {\n    config = this._mergeConfigObj(config)\n    config = this._configAfterMerge(config)\n    this._typeCheckConfig(config)\n    return config\n  }\n\n  _configAfterMerge(config) {\n    return config\n  }\n\n  _mergeConfigObj(config, element) {\n    const jsonConfig = isElement(element) ? Manipulator.getDataAttribute(element, 'config') : {} // try to parse\n\n    return {\n      ...this.constructor.Default,\n      ...(typeof jsonConfig === 'object' ? jsonConfig : {}),\n      ...(isElement(element) ? Manipulator.getDataAttributes(element) : {}),\n      ...(typeof config === 'object' ? config : {})\n    }\n  }\n\n  _typeCheckConfig(config, configTypes = this.constructor.DefaultType) {\n    for (const [property, expectedTypes] of Object.entries(configTypes)) {\n      const value = config[property]\n      const valueType = isElement(value) ? 'element' : toType(value)\n\n      if (!new RegExp(expectedTypes).test(valueType)) {\n        throw new TypeError(\n          `${this.constructor.NAME.toUpperCase()}: Option \"${property}\" provided type \"${valueType}\" but expected type \"${expectedTypes}\".`\n        )\n      }\n    }\n  }\n}\n\nexport default Config\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap base-component.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Data from './dom/data.js'\nimport EventHandler from './dom/event-handler.js'\nimport Config from './util/config.js'\nimport { executeAfterTransition, getElement } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst VERSION = '5.3.1'\n\n/**\n * Class definition\n */\n\nclass BaseComponent extends Config {\n  constructor(element, config) {\n    super()\n\n    element = getElement(element)\n    if (!element) {\n      return\n    }\n\n    this._element = element\n    this._config = this._getConfig(config)\n\n    Data.set(this._element, this.constructor.DATA_KEY, this)\n  }\n\n  // Public\n  dispose() {\n    Data.remove(this._element, this.constructor.DATA_KEY)\n    EventHandler.off(this._element, this.constructor.EVENT_KEY)\n\n    for (const propertyName of Object.getOwnPropertyNames(this)) {\n      this[propertyName] = null\n    }\n  }\n\n  _queueCallback(callback, element, isAnimated = true) {\n    executeAfterTransition(callback, element, isAnimated)\n  }\n\n  _getConfig(config) {\n    config = this._mergeConfigObj(config, this._element)\n    config = this._configAfterMerge(config)\n    this._typeCheckConfig(config)\n    return config\n  }\n\n  // Static\n  static getInstance(element) {\n    return Data.get(getElement(element), this.DATA_KEY)\n  }\n\n  static getOrCreateInstance(element, config = {}) {\n    return this.getInstance(element) || new this(element, typeof config === 'object' ? config : null)\n  }\n\n  static get VERSION() {\n    return VERSION\n  }\n\n  static get DATA_KEY() {\n    return `bs.${this.NAME}`\n  }\n\n  static get EVENT_KEY() {\n    return `.${this.DATA_KEY}`\n  }\n\n  static eventName(name) {\n    return `${name}${this.EVENT_KEY}`\n  }\n}\n\nexport default BaseComponent\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap dom/selector-engine.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport { isDisabled, isVisible, parseSelector } from '../util/index.js'\n\nconst getSelector = element => {\n  let selector = element.getAttribute('data-bs-target')\n\n  if (!selector || selector === '#') {\n    let hrefAttribute = element.getAttribute('href')\n\n    // The only valid content that could double as a selector are IDs or classes,\n    // so everything starting with `#` or `.`. If a \"real\" URL is used as the selector,\n    // `document.querySelector` will rightfully complain it is invalid.\n    // See https://github.com/twbs/bootstrap/issues/32273\n    if (!hrefAttribute || (!hrefAttribute.includes('#') && !hrefAttribute.startsWith('.'))) {\n      return null\n    }\n\n    // Just in case some CMS puts out a full URL with the anchor appended\n    if (hrefAttribute.includes('#') && !hrefAttribute.startsWith('#')) {\n      hrefAttribute = `#${hrefAttribute.split('#')[1]}`\n    }\n\n    selector = hrefAttribute && hrefAttribute !== '#' ? hrefAttribute.trim() : null\n  }\n\n  return parseSelector(selector)\n}\n\nconst SelectorEngine = {\n  find(selector, element = document.documentElement) {\n    return [].concat(...Element.prototype.querySelectorAll.call(element, selector))\n  },\n\n  findOne(selector, element = document.documentElement) {\n    return Element.prototype.querySelector.call(element, selector)\n  },\n\n  children(element, selector) {\n    return [].concat(...element.children).filter(child => child.matches(selector))\n  },\n\n  parents(element, selector) {\n    const parents = []\n    let ancestor = element.parentNode.closest(selector)\n\n    while (ancestor) {\n      parents.push(ancestor)\n      ancestor = ancestor.parentNode.closest(selector)\n    }\n\n    return parents\n  },\n\n  prev(element, selector) {\n    let previous = element.previousElementSibling\n\n    while (previous) {\n      if (previous.matches(selector)) {\n        return [previous]\n      }\n\n      previous = previous.previousElementSibling\n    }\n\n    return []\n  },\n  // TODO: this is now unused; remove later along with prev()\n  next(element, selector) {\n    let next = element.nextElementSibling\n\n    while (next) {\n      if (next.matches(selector)) {\n        return [next]\n      }\n\n      next = next.nextElementSibling\n    }\n\n    return []\n  },\n\n  focusableChildren(element) {\n    const focusables = [\n      'a',\n      'button',\n      'input',\n      'textarea',\n      'select',\n      'details',\n      '[tabindex]',\n      '[contenteditable=\"true\"]'\n    ].map(selector => `${selector}:not([tabindex^=\"-\"])`).join(',')\n\n    return this.find(focusables, element).filter(el => !isDisabled(el) && isVisible(el))\n  },\n\n  getSelectorFromElement(element) {\n    const selector = getSelector(element)\n\n    if (selector) {\n      return SelectorEngine.findOne(selector) ? selector : null\n    }\n\n    return null\n  },\n\n  getElementFromSelector(element) {\n    const selector = getSelector(element)\n\n    return selector ? SelectorEngine.findOne(selector) : null\n  },\n\n  getMultipleElementsFromSelector(element) {\n    const selector = getSelector(element)\n\n    return selector ? SelectorEngine.find(selector) : []\n  }\n}\n\nexport default SelectorEngine\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/component-functions.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport SelectorEngine from '../dom/selector-engine.js'\nimport { isDisabled } from './index.js'\n\nconst enableDismissTrigger = (component, method = 'hide') => {\n  const clickEvent = `click.dismiss${component.EVENT_KEY}`\n  const name = component.NAME\n\n  EventHandler.on(document, clickEvent, `[data-bs-dismiss=\"${name}\"]`, function (event) {\n    if (['A', 'AREA'].includes(this.tagName)) {\n      event.preventDefault()\n    }\n\n    if (isDisabled(this)) {\n      return\n    }\n\n    const target = SelectorEngine.getElementFromSelector(this) || this.closest(`.${name}`)\n    const instance = component.getOrCreateInstance(target)\n\n    // Method argument is left, for Alert and only, as it doesn't implement the 'hide' method\n    instance[method]()\n  })\n}\n\nexport {\n  enableDismissTrigger\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap alert.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport { defineJQueryPlugin } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'alert'\nconst DATA_KEY = 'bs.alert'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_CLOSE = `close${EVENT_KEY}`\nconst EVENT_CLOSED = `closed${EVENT_KEY}`\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\n\n/**\n * Class definition\n */\n\nclass Alert extends BaseComponent {\n  // Getters\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  close() {\n    const closeEvent = EventHandler.trigger(this._element, EVENT_CLOSE)\n\n    if (closeEvent.defaultPrevented) {\n      return\n    }\n\n    this._element.classList.remove(CLASS_NAME_SHOW)\n\n    const isAnimated = this._element.classList.contains(CLASS_NAME_FADE)\n    this._queueCallback(() => this._destroyElement(), this._element, isAnimated)\n  }\n\n  // Private\n  _destroyElement() {\n    this._element.remove()\n    EventHandler.trigger(this._element, EVENT_CLOSED)\n    this.dispose()\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Alert.getOrCreateInstance(this)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config](this)\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nenableDismissTrigger(Alert, 'close')\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Alert)\n\nexport default Alert\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap button.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport { defineJQueryPlugin } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'button'\nconst DATA_KEY = 'bs.button'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst CLASS_NAME_ACTIVE = 'active'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"button\"]'\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\n/**\n * Class definition\n */\n\nclass Button extends BaseComponent {\n  // Getters\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle() {\n    // Toggle class and sync the `aria-pressed` attribute with the return value of the `.toggle()` method\n    this._element.setAttribute('aria-pressed', this._element.classList.toggle(CLASS_NAME_ACTIVE))\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Button.getOrCreateInstance(this)\n\n      if (config === 'toggle') {\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, event => {\n  event.preventDefault()\n\n  const button = event.target.closest(SELECTOR_DATA_TOGGLE)\n  const data = Button.getOrCreateInstance(button)\n\n  data.toggle()\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Button)\n\nexport default Button\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/swipe.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport Config from './config.js'\nimport { execute } from './index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'swipe'\nconst EVENT_KEY = '.bs.swipe'\nconst EVENT_TOUCHSTART = `touchstart${EVENT_KEY}`\nconst EVENT_TOUCHMOVE = `touchmove${EVENT_KEY}`\nconst EVENT_TOUCHEND = `touchend${EVENT_KEY}`\nconst EVENT_POINTERDOWN = `pointerdown${EVENT_KEY}`\nconst EVENT_POINTERUP = `pointerup${EVENT_KEY}`\nconst POINTER_TYPE_TOUCH = 'touch'\nconst POINTER_TYPE_PEN = 'pen'\nconst CLASS_NAME_POINTER_EVENT = 'pointer-event'\nconst SWIPE_THRESHOLD = 40\n\nconst Default = {\n  endCallback: null,\n  leftCallback: null,\n  rightCallback: null\n}\n\nconst DefaultType = {\n  endCallback: '(function|null)',\n  leftCallback: '(function|null)',\n  rightCallback: '(function|null)'\n}\n\n/**\n * Class definition\n */\n\nclass Swipe extends Config {\n  constructor(element, config) {\n    super()\n    this._element = element\n\n    if (!element || !Swipe.isSupported()) {\n      return\n    }\n\n    this._config = this._getConfig(config)\n    this._deltaX = 0\n    this._supportPointerEvents = Boolean(window.PointerEvent)\n    this._initEvents()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  dispose() {\n    EventHandler.off(this._element, EVENT_KEY)\n  }\n\n  // Private\n  _start(event) {\n    if (!this._supportPointerEvents) {\n      this._deltaX = event.touches[0].clientX\n\n      return\n    }\n\n    if (this._eventIsPointerPenTouch(event)) {\n      this._deltaX = event.clientX\n    }\n  }\n\n  _end(event) {\n    if (this._eventIsPointerPenTouch(event)) {\n      this._deltaX = event.clientX - this._deltaX\n    }\n\n    this._handleSwipe()\n    execute(this._config.endCallback)\n  }\n\n  _move(event) {\n    this._deltaX = event.touches && event.touches.length > 1 ?\n      0 :\n      event.touches[0].clientX - this._deltaX\n  }\n\n  _handleSwipe() {\n    const absDeltaX = Math.abs(this._deltaX)\n\n    if (absDeltaX <= SWIPE_THRESHOLD) {\n      return\n    }\n\n    const direction = absDeltaX / this._deltaX\n\n    this._deltaX = 0\n\n    if (!direction) {\n      return\n    }\n\n    execute(direction > 0 ? this._config.rightCallback : this._config.leftCallback)\n  }\n\n  _initEvents() {\n    if (this._supportPointerEvents) {\n      EventHandler.on(this._element, EVENT_POINTERDOWN, event => this._start(event))\n      EventHandler.on(this._element, EVENT_POINTERUP, event => this._end(event))\n\n      this._element.classList.add(CLASS_NAME_POINTER_EVENT)\n    } else {\n      EventHandler.on(this._element, EVENT_TOUCHSTART, event => this._start(event))\n      EventHandler.on(this._element, EVENT_TOUCHMOVE, event => this._move(event))\n      EventHandler.on(this._element, EVENT_TOUCHEND, event => this._end(event))\n    }\n  }\n\n  _eventIsPointerPenTouch(event) {\n    return this._supportPointerEvents && (event.pointerType === POINTER_TYPE_PEN || event.pointerType === POINTER_TYPE_TOUCH)\n  }\n\n  // Static\n  static isSupported() {\n    return 'ontouchstart' in document.documentElement || navigator.maxTouchPoints > 0\n  }\n}\n\nexport default Swipe\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap carousel.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport Manipulator from './dom/manipulator.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport {\n  defineJQueryPlugin,\n  getNextActiveElement,\n  isRTL,\n  isVisible,\n  reflow,\n  triggerTransitionEnd\n} from './util/index.js'\nimport Swipe from './util/swipe.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'carousel'\nconst DATA_KEY = 'bs.carousel'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ARROW_LEFT_KEY = 'ArrowLeft'\nconst ARROW_RIGHT_KEY = 'ArrowRight'\nconst TOUCHEVENT_COMPAT_WAIT = 500 // Time for mouse compat events to fire after touch\n\nconst ORDER_NEXT = 'next'\nconst ORDER_PREV = 'prev'\nconst DIRECTION_LEFT = 'left'\nconst DIRECTION_RIGHT = 'right'\n\nconst EVENT_SLIDE = `slide${EVENT_KEY}`\nconst EVENT_SLID = `slid${EVENT_KEY}`\nconst EVENT_KEYDOWN = `keydown${EVENT_KEY}`\nconst EVENT_MOUSEENTER = `mouseenter${EVENT_KEY}`\nconst EVENT_MOUSELEAVE = `mouseleave${EVENT_KEY}`\nconst EVENT_DRAG_START = `dragstart${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_CAROUSEL = 'carousel'\nconst CLASS_NAME_ACTIVE = 'active'\nconst CLASS_NAME_SLIDE = 'slide'\nconst CLASS_NAME_END = 'carousel-item-end'\nconst CLASS_NAME_START = 'carousel-item-start'\nconst CLASS_NAME_NEXT = 'carousel-item-next'\nconst CLASS_NAME_PREV = 'carousel-item-prev'\n\nconst SELECTOR_ACTIVE = '.active'\nconst SELECTOR_ITEM = '.carousel-item'\nconst SELECTOR_ACTIVE_ITEM = SELECTOR_ACTIVE + SELECTOR_ITEM\nconst SELECTOR_ITEM_IMG = '.carousel-item img'\nconst SELECTOR_INDICATORS = '.carousel-indicators'\nconst SELECTOR_DATA_SLIDE = '[data-bs-slide], [data-bs-slide-to]'\nconst SELECTOR_DATA_RIDE = '[data-bs-ride=\"carousel\"]'\n\nconst KEY_TO_DIRECTION = {\n  [ARROW_LEFT_KEY]: DIRECTION_RIGHT,\n  [ARROW_RIGHT_KEY]: DIRECTION_LEFT\n}\n\nconst Default = {\n  interval: 5000,\n  keyboard: true,\n  pause: 'hover',\n  ride: false,\n  touch: true,\n  wrap: true\n}\n\nconst DefaultType = {\n  interval: '(number|boolean)', // TODO:v6 remove boolean support\n  keyboard: 'boolean',\n  pause: '(string|boolean)',\n  ride: '(boolean|string)',\n  touch: 'boolean',\n  wrap: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Carousel extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._interval = null\n    this._activeElement = null\n    this._isSliding = false\n    this.touchTimeout = null\n    this._swipeHelper = null\n\n    this._indicatorsElement = SelectorEngine.findOne(SELECTOR_INDICATORS, this._element)\n    this._addEventListeners()\n\n    if (this._config.ride === CLASS_NAME_CAROUSEL) {\n      this.cycle()\n    }\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  next() {\n    this._slide(ORDER_NEXT)\n  }\n\n  nextWhenVisible() {\n    // FIXME TODO use `document.visibilityState`\n    // Don't call next when the page isn't visible\n    // or the carousel or its parent isn't visible\n    if (!document.hidden && isVisible(this._element)) {\n      this.next()\n    }\n  }\n\n  prev() {\n    this._slide(ORDER_PREV)\n  }\n\n  pause() {\n    if (this._isSliding) {\n      triggerTransitionEnd(this._element)\n    }\n\n    this._clearInterval()\n  }\n\n  cycle() {\n    this._clearInterval()\n    this._updateInterval()\n\n    this._interval = setInterval(() => this.nextWhenVisible(), this._config.interval)\n  }\n\n  _maybeEnableCycle() {\n    if (!this._config.ride) {\n      return\n    }\n\n    if (this._isSliding) {\n      EventHandler.one(this._element, EVENT_SLID, () => this.cycle())\n      return\n    }\n\n    this.cycle()\n  }\n\n  to(index) {\n    const items = this._getItems()\n    if (index > items.length - 1 || index < 0) {\n      return\n    }\n\n    if (this._isSliding) {\n      EventHandler.one(this._element, EVENT_SLID, () => this.to(index))\n      return\n    }\n\n    const activeIndex = this._getItemIndex(this._getActive())\n    if (activeIndex === index) {\n      return\n    }\n\n    const order = index > activeIndex ? ORDER_NEXT : ORDER_PREV\n\n    this._slide(order, items[index])\n  }\n\n  dispose() {\n    if (this._swipeHelper) {\n      this._swipeHelper.dispose()\n    }\n\n    super.dispose()\n  }\n\n  // Private\n  _configAfterMerge(config) {\n    config.defaultInterval = config.interval\n    return config\n  }\n\n  _addEventListeners() {\n    if (this._config.keyboard) {\n      EventHandler.on(this._element, EVENT_KEYDOWN, event => this._keydown(event))\n    }\n\n    if (this._config.pause === 'hover') {\n      EventHandler.on(this._element, EVENT_MOUSEENTER, () => this.pause())\n      EventHandler.on(this._element, EVENT_MOUSELEAVE, () => this._maybeEnableCycle())\n    }\n\n    if (this._config.touch && Swipe.isSupported()) {\n      this._addTouchEventListeners()\n    }\n  }\n\n  _addTouchEventListeners() {\n    for (const img of SelectorEngine.find(SELECTOR_ITEM_IMG, this._element)) {\n      EventHandler.on(img, EVENT_DRAG_START, event => event.preventDefault())\n    }\n\n    const endCallBack = () => {\n      if (this._config.pause !== 'hover') {\n        return\n      }\n\n      // If it's a touch-enabled device, mouseenter/leave are fired as\n      // part of the mouse compatibility events on first tap - the carousel\n      // would stop cycling until user tapped out of it;\n      // here, we listen for touchend, explicitly pause the carousel\n      // (as if it's the second time we tap on it, mouseenter compat event\n      // is NOT fired) and after a timeout (to allow for mouse compatibility\n      // events to fire) we explicitly restart cycling\n\n      this.pause()\n      if (this.touchTimeout) {\n        clearTimeout(this.touchTimeout)\n      }\n\n      this.touchTimeout = setTimeout(() => this._maybeEnableCycle(), TOUCHEVENT_COMPAT_WAIT + this._config.interval)\n    }\n\n    const swipeConfig = {\n      leftCallback: () => this._slide(this._directionToOrder(DIRECTION_LEFT)),\n      rightCallback: () => this._slide(this._directionToOrder(DIRECTION_RIGHT)),\n      endCallback: endCallBack\n    }\n\n    this._swipeHelper = new Swipe(this._element, swipeConfig)\n  }\n\n  _keydown(event) {\n    if (/input|textarea/i.test(event.target.tagName)) {\n      return\n    }\n\n    const direction = KEY_TO_DIRECTION[event.key]\n    if (direction) {\n      event.preventDefault()\n      this._slide(this._directionToOrder(direction))\n    }\n  }\n\n  _getItemIndex(element) {\n    return this._getItems().indexOf(element)\n  }\n\n  _setActiveIndicatorElement(index) {\n    if (!this._indicatorsElement) {\n      return\n    }\n\n    const activeIndicator = SelectorEngine.findOne(SELECTOR_ACTIVE, this._indicatorsElement)\n\n    activeIndicator.classList.remove(CLASS_NAME_ACTIVE)\n    activeIndicator.removeAttribute('aria-current')\n\n    const newActiveIndicator = SelectorEngine.findOne(`[data-bs-slide-to=\"${index}\"]`, this._indicatorsElement)\n\n    if (newActiveIndicator) {\n      newActiveIndicator.classList.add(CLASS_NAME_ACTIVE)\n      newActiveIndicator.setAttribute('aria-current', 'true')\n    }\n  }\n\n  _updateInterval() {\n    const element = this._activeElement || this._getActive()\n\n    if (!element) {\n      return\n    }\n\n    const elementInterval = Number.parseInt(element.getAttribute('data-bs-interval'), 10)\n\n    this._config.interval = elementInterval || this._config.defaultInterval\n  }\n\n  _slide(order, element = null) {\n    if (this._isSliding) {\n      return\n    }\n\n    const activeElement = this._getActive()\n    const isNext = order === ORDER_NEXT\n    const nextElement = element || getNextActiveElement(this._getItems(), activeElement, isNext, this._config.wrap)\n\n    if (nextElement === activeElement) {\n      return\n    }\n\n    const nextElementIndex = this._getItemIndex(nextElement)\n\n    const triggerEvent = eventName => {\n      return EventHandler.trigger(this._element, eventName, {\n        relatedTarget: nextElement,\n        direction: this._orderToDirection(order),\n        from: this._getItemIndex(activeElement),\n        to: nextElementIndex\n      })\n    }\n\n    const slideEvent = triggerEvent(EVENT_SLIDE)\n\n    if (slideEvent.defaultPrevented) {\n      return\n    }\n\n    if (!activeElement || !nextElement) {\n      // Some weirdness is happening, so we bail\n      // TODO: change tests that use empty divs to avoid this check\n      return\n    }\n\n    const isCycling = Boolean(this._interval)\n    this.pause()\n\n    this._isSliding = true\n\n    this._setActiveIndicatorElement(nextElementIndex)\n    this._activeElement = nextElement\n\n    const directionalClassName = isNext ? CLASS_NAME_START : CLASS_NAME_END\n    const orderClassName = isNext ? CLASS_NAME_NEXT : CLASS_NAME_PREV\n\n    nextElement.classList.add(orderClassName)\n\n    reflow(nextElement)\n\n    activeElement.classList.add(directionalClassName)\n    nextElement.classList.add(directionalClassName)\n\n    const completeCallBack = () => {\n      nextElement.classList.remove(directionalClassName, orderClassName)\n      nextElement.classList.add(CLASS_NAME_ACTIVE)\n\n      activeElement.classList.remove(CLASS_NAME_ACTIVE, orderClassName, directionalClassName)\n\n      this._isSliding = false\n\n      triggerEvent(EVENT_SLID)\n    }\n\n    this._queueCallback(completeCallBack, activeElement, this._isAnimated())\n\n    if (isCycling) {\n      this.cycle()\n    }\n  }\n\n  _isAnimated() {\n    return this._element.classList.contains(CLASS_NAME_SLIDE)\n  }\n\n  _getActive() {\n    return SelectorEngine.findOne(SELECTOR_ACTIVE_ITEM, this._element)\n  }\n\n  _getItems() {\n    return SelectorEngine.find(SELECTOR_ITEM, this._element)\n  }\n\n  _clearInterval() {\n    if (this._interval) {\n      clearInterval(this._interval)\n      this._interval = null\n    }\n  }\n\n  _directionToOrder(direction) {\n    if (isRTL()) {\n      return direction === DIRECTION_LEFT ? ORDER_PREV : ORDER_NEXT\n    }\n\n    return direction === DIRECTION_LEFT ? ORDER_NEXT : ORDER_PREV\n  }\n\n  _orderToDirection(order) {\n    if (isRTL()) {\n      return order === ORDER_PREV ? DIRECTION_LEFT : DIRECTION_RIGHT\n    }\n\n    return order === ORDER_PREV ? DIRECTION_RIGHT : DIRECTION_LEFT\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Carousel.getOrCreateInstance(this, config)\n\n      if (typeof config === 'number') {\n        data.to(config)\n        return\n      }\n\n      if (typeof config === 'string') {\n        if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_SLIDE, function (event) {\n  const target = SelectorEngine.getElementFromSelector(this)\n\n  if (!target || !target.classList.contains(CLASS_NAME_CAROUSEL)) {\n    return\n  }\n\n  event.preventDefault()\n\n  const carousel = Carousel.getOrCreateInstance(target)\n  const slideIndex = this.getAttribute('data-bs-slide-to')\n\n  if (slideIndex) {\n    carousel.to(slideIndex)\n    carousel._maybeEnableCycle()\n    return\n  }\n\n  if (Manipulator.getDataAttribute(this, 'slide') === 'next') {\n    carousel.next()\n    carousel._maybeEnableCycle()\n    return\n  }\n\n  carousel.prev()\n  carousel._maybeEnableCycle()\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  const carousels = SelectorEngine.find(SELECTOR_DATA_RIDE)\n\n  for (const carousel of carousels) {\n    Carousel.getOrCreateInstance(carousel)\n  }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Carousel)\n\nexport default Carousel\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap collapse.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport {\n  defineJQueryPlugin,\n  getElement,\n  reflow\n} from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'collapse'\nconst DATA_KEY = 'bs.collapse'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_COLLAPSE = 'collapse'\nconst CLASS_NAME_COLLAPSING = 'collapsing'\nconst CLASS_NAME_COLLAPSED = 'collapsed'\nconst CLASS_NAME_DEEPER_CHILDREN = `:scope .${CLASS_NAME_COLLAPSE} .${CLASS_NAME_COLLAPSE}`\nconst CLASS_NAME_HORIZONTAL = 'collapse-horizontal'\n\nconst WIDTH = 'width'\nconst HEIGHT = 'height'\n\nconst SELECTOR_ACTIVES = '.collapse.show, .collapse.collapsing'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"collapse\"]'\n\nconst Default = {\n  parent: null,\n  toggle: true\n}\n\nconst DefaultType = {\n  parent: '(null|element)',\n  toggle: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Collapse extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._isTransitioning = false\n    this._triggerArray = []\n\n    const toggleList = SelectorEngine.find(SELECTOR_DATA_TOGGLE)\n\n    for (const elem of toggleList) {\n      const selector = SelectorEngine.getSelectorFromElement(elem)\n      const filterElement = SelectorEngine.find(selector)\n        .filter(foundElement => foundElement === this._element)\n\n      if (selector !== null && filterElement.length) {\n        this._triggerArray.push(elem)\n      }\n    }\n\n    this._initializeChildren()\n\n    if (!this._config.parent) {\n      this._addAriaAndCollapsedClass(this._triggerArray, this._isShown())\n    }\n\n    if (this._config.toggle) {\n      this.toggle()\n    }\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle() {\n    if (this._isShown()) {\n      this.hide()\n    } else {\n      this.show()\n    }\n  }\n\n  show() {\n    if (this._isTransitioning || this._isShown()) {\n      return\n    }\n\n    let activeChildren = []\n\n    // find active children\n    if (this._config.parent) {\n      activeChildren = this._getFirstLevelChildren(SELECTOR_ACTIVES)\n        .filter(element => element !== this._element)\n        .map(element => Collapse.getOrCreateInstance(element, { toggle: false }))\n    }\n\n    if (activeChildren.length && activeChildren[0]._isTransitioning) {\n      return\n    }\n\n    const startEvent = EventHandler.trigger(this._element, EVENT_SHOW)\n    if (startEvent.defaultPrevented) {\n      return\n    }\n\n    for (const activeInstance of activeChildren) {\n      activeInstance.hide()\n    }\n\n    const dimension = this._getDimension()\n\n    this._element.classList.remove(CLASS_NAME_COLLAPSE)\n    this._element.classList.add(CLASS_NAME_COLLAPSING)\n\n    this._element.style[dimension] = 0\n\n    this._addAriaAndCollapsedClass(this._triggerArray, true)\n    this._isTransitioning = true\n\n    const complete = () => {\n      this._isTransitioning = false\n\n      this._element.classList.remove(CLASS_NAME_COLLAPSING)\n      this._element.classList.add(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n      this._element.style[dimension] = ''\n\n      EventHandler.trigger(this._element, EVENT_SHOWN)\n    }\n\n    const capitalizedDimension = dimension[0].toUpperCase() + dimension.slice(1)\n    const scrollSize = `scroll${capitalizedDimension}`\n\n    this._queueCallback(complete, this._element, true)\n    this._element.style[dimension] = `${this._element[scrollSize]}px`\n  }\n\n  hide() {\n    if (this._isTransitioning || !this._isShown()) {\n      return\n    }\n\n    const startEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n    if (startEvent.defaultPrevented) {\n      return\n    }\n\n    const dimension = this._getDimension()\n\n    this._element.style[dimension] = `${this._element.getBoundingClientRect()[dimension]}px`\n\n    reflow(this._element)\n\n    this._element.classList.add(CLASS_NAME_COLLAPSING)\n    this._element.classList.remove(CLASS_NAME_COLLAPSE, CLASS_NAME_SHOW)\n\n    for (const trigger of this._triggerArray) {\n      const element = SelectorEngine.getElementFromSelector(trigger)\n\n      if (element && !this._isShown(element)) {\n        this._addAriaAndCollapsedClass([trigger], false)\n      }\n    }\n\n    this._isTransitioning = true\n\n    const complete = () => {\n      this._isTransitioning = false\n      this._element.classList.remove(CLASS_NAME_COLLAPSING)\n      this._element.classList.add(CLASS_NAME_COLLAPSE)\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    }\n\n    this._element.style[dimension] = ''\n\n    this._queueCallback(complete, this._element, true)\n  }\n\n  _isShown(element = this._element) {\n    return element.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  // Private\n  _configAfterMerge(config) {\n    config.toggle = Boolean(config.toggle) // Coerce string values\n    config.parent = getElement(config.parent)\n    return config\n  }\n\n  _getDimension() {\n    return this._element.classList.contains(CLASS_NAME_HORIZONTAL) ? WIDTH : HEIGHT\n  }\n\n  _initializeChildren() {\n    if (!this._config.parent) {\n      return\n    }\n\n    const children = this._getFirstLevelChildren(SELECTOR_DATA_TOGGLE)\n\n    for (const element of children) {\n      const selected = SelectorEngine.getElementFromSelector(element)\n\n      if (selected) {\n        this._addAriaAndCollapsedClass([element], this._isShown(selected))\n      }\n    }\n  }\n\n  _getFirstLevelChildren(selector) {\n    const children = SelectorEngine.find(CLASS_NAME_DEEPER_CHILDREN, this._config.parent)\n    // remove children if greater depth\n    return SelectorEngine.find(selector, this._config.parent).filter(element => !children.includes(element))\n  }\n\n  _addAriaAndCollapsedClass(triggerArray, isOpen) {\n    if (!triggerArray.length) {\n      return\n    }\n\n    for (const element of triggerArray) {\n      element.classList.toggle(CLASS_NAME_COLLAPSED, !isOpen)\n      element.setAttribute('aria-expanded', isOpen)\n    }\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    const _config = {}\n    if (typeof config === 'string' && /show|hide/.test(config)) {\n      _config.toggle = false\n    }\n\n    return this.each(function () {\n      const data = Collapse.getOrCreateInstance(this, _config)\n\n      if (typeof config === 'string') {\n        if (typeof data[config] === 'undefined') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config]()\n      }\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  // preventDefault only for <a> elements (which change the URL) not inside the collapsible element\n  if (event.target.tagName === 'A' || (event.delegateTarget && event.delegateTarget.tagName === 'A')) {\n    event.preventDefault()\n  }\n\n  for (const element of SelectorEngine.getMultipleElementsFromSelector(this)) {\n    Collapse.getOrCreateInstance(element, { toggle: false }).toggle()\n  }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Collapse)\n\nexport default Collapse\n","export var top = 'top';\nexport var bottom = 'bottom';\nexport var right = 'right';\nexport var left = 'left';\nexport var auto = 'auto';\nexport var basePlacements = [top, bottom, right, left];\nexport var start = 'start';\nexport var end = 'end';\nexport var clippingParents = 'clippingParents';\nexport var viewport = 'viewport';\nexport var popper = 'popper';\nexport var reference = 'reference';\nexport var variationPlacements = /*#__PURE__*/basePlacements.reduce(function (acc, placement) {\n  return acc.concat([placement + \"-\" + start, placement + \"-\" + end]);\n}, []);\nexport var placements = /*#__PURE__*/[].concat(basePlacements, [auto]).reduce(function (acc, placement) {\n  return acc.concat([placement, placement + \"-\" + start, placement + \"-\" + end]);\n}, []); // modifiers that need to read the DOM\n\nexport var beforeRead = 'beforeRead';\nexport var read = 'read';\nexport var afterRead = 'afterRead'; // pure-logic modifiers\n\nexport var beforeMain = 'beforeMain';\nexport var main = 'main';\nexport var afterMain = 'afterMain'; // modifier with the purpose to write to the DOM (or write into a framework state)\n\nexport var beforeWrite = 'beforeWrite';\nexport var write = 'write';\nexport var afterWrite = 'afterWrite';\nexport var modifierPhases = [beforeRead, read, afterRead, beforeMain, main, afterMain, beforeWrite, write, afterWrite];","export default function getNodeName(element) {\n  return element ? (element.nodeName || '').toLowerCase() : null;\n}","export default function getWindow(node) {\n  if (node == null) {\n    return window;\n  }\n\n  if (node.toString() !== '[object Window]') {\n    var ownerDocument = node.ownerDocument;\n    return ownerDocument ? ownerDocument.defaultView || window : window;\n  }\n\n  return node;\n}","import getWindow from \"./getWindow.js\";\n\nfunction isElement(node) {\n  var OwnElement = getWindow(node).Element;\n  return node instanceof OwnElement || node instanceof Element;\n}\n\nfunction isHTMLElement(node) {\n  var OwnElement = getWindow(node).HTMLElement;\n  return node instanceof OwnElement || node instanceof HTMLElement;\n}\n\nfunction isShadowRoot(node) {\n  // IE 11 has no ShadowRoot\n  if (typeof ShadowRoot === 'undefined') {\n    return false;\n  }\n\n  var OwnElement = getWindow(node).ShadowRoot;\n  return node instanceof OwnElement || node instanceof ShadowRoot;\n}\n\nexport { isElement, isHTMLElement, isShadowRoot };","import getNodeName from \"../dom-utils/getNodeName.js\";\nimport { isHTMLElement } from \"../dom-utils/instanceOf.js\"; // This modifier takes the styles prepared by the `computeStyles` modifier\n// and applies them to the HTMLElements such as popper and arrow\n\nfunction applyStyles(_ref) {\n  var state = _ref.state;\n  Object.keys(state.elements).forEach(function (name) {\n    var style = state.styles[name] || {};\n    var attributes = state.attributes[name] || {};\n    var element = state.elements[name]; // arrow is optional + virtual elements\n\n    if (!isHTMLElement(element) || !getNodeName(element)) {\n      return;\n    } // Flow doesn't support to extend this property, but it's the most\n    // effective way to apply styles to an HTMLElement\n    // $FlowFixMe[cannot-write]\n\n\n    Object.assign(element.style, style);\n    Object.keys(attributes).forEach(function (name) {\n      var value = attributes[name];\n\n      if (value === false) {\n        element.removeAttribute(name);\n      } else {\n        element.setAttribute(name, value === true ? '' : value);\n      }\n    });\n  });\n}\n\nfunction effect(_ref2) {\n  var state = _ref2.state;\n  var initialStyles = {\n    popper: {\n      position: state.options.strategy,\n      left: '0',\n      top: '0',\n      margin: '0'\n    },\n    arrow: {\n      position: 'absolute'\n    },\n    reference: {}\n  };\n  Object.assign(state.elements.popper.style, initialStyles.popper);\n  state.styles = initialStyles;\n\n  if (state.elements.arrow) {\n    Object.assign(state.elements.arrow.style, initialStyles.arrow);\n  }\n\n  return function () {\n    Object.keys(state.elements).forEach(function (name) {\n      var element = state.elements[name];\n      var attributes = state.attributes[name] || {};\n      var styleProperties = Object.keys(state.styles.hasOwnProperty(name) ? state.styles[name] : initialStyles[name]); // Set all values to an empty string to unset them\n\n      var style = styleProperties.reduce(function (style, property) {\n        style[property] = '';\n        return style;\n      }, {}); // arrow is optional + virtual elements\n\n      if (!isHTMLElement(element) || !getNodeName(element)) {\n        return;\n      }\n\n      Object.assign(element.style, style);\n      Object.keys(attributes).forEach(function (attribute) {\n        element.removeAttribute(attribute);\n      });\n    });\n  };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'applyStyles',\n  enabled: true,\n  phase: 'write',\n  fn: applyStyles,\n  effect: effect,\n  requires: ['computeStyles']\n};","import { auto } from \"../enums.js\";\nexport default function getBasePlacement(placement) {\n  return placement.split('-')[0];\n}","export var max = Math.max;\nexport var min = Math.min;\nexport var round = Math.round;","export default function getUAString() {\n  var uaData = navigator.userAgentData;\n\n  if (uaData != null && uaData.brands && Array.isArray(uaData.brands)) {\n    return uaData.brands.map(function (item) {\n      return item.brand + \"/\" + item.version;\n    }).join(' ');\n  }\n\n  return navigator.userAgent;\n}","import getUAString from \"../utils/userAgent.js\";\nexport default function isLayoutViewport() {\n  return !/^((?!chrome|android).)*safari/i.test(getUAString());\n}","import { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport { round } from \"../utils/math.js\";\nimport getWindow from \"./getWindow.js\";\nimport isLayoutViewport from \"./isLayoutViewport.js\";\nexport default function getBoundingClientRect(element, includeScale, isFixedStrategy) {\n  if (includeScale === void 0) {\n    includeScale = false;\n  }\n\n  if (isFixedStrategy === void 0) {\n    isFixedStrategy = false;\n  }\n\n  var clientRect = element.getBoundingClientRect();\n  var scaleX = 1;\n  var scaleY = 1;\n\n  if (includeScale && isHTMLElement(element)) {\n    scaleX = element.offsetWidth > 0 ? round(clientRect.width) / element.offsetWidth || 1 : 1;\n    scaleY = element.offsetHeight > 0 ? round(clientRect.height) / element.offsetHeight || 1 : 1;\n  }\n\n  var _ref = isElement(element) ? getWindow(element) : window,\n      visualViewport = _ref.visualViewport;\n\n  var addVisualOffsets = !isLayoutViewport() && isFixedStrategy;\n  var x = (clientRect.left + (addVisualOffsets && visualViewport ? visualViewport.offsetLeft : 0)) / scaleX;\n  var y = (clientRect.top + (addVisualOffsets && visualViewport ? visualViewport.offsetTop : 0)) / scaleY;\n  var width = clientRect.width / scaleX;\n  var height = clientRect.height / scaleY;\n  return {\n    width: width,\n    height: height,\n    top: y,\n    right: x + width,\n    bottom: y + height,\n    left: x,\n    x: x,\n    y: y\n  };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\"; // Returns the layout rect of an element relative to its offsetParent. Layout\n// means it doesn't take into account transforms.\n\nexport default function getLayoutRect(element) {\n  var clientRect = getBoundingClientRect(element); // Use the clientRect sizes if it's not been transformed.\n  // Fixes https://github.com/popperjs/popper-core/issues/1223\n\n  var width = element.offsetWidth;\n  var height = element.offsetHeight;\n\n  if (Math.abs(clientRect.width - width) <= 1) {\n    width = clientRect.width;\n  }\n\n  if (Math.abs(clientRect.height - height) <= 1) {\n    height = clientRect.height;\n  }\n\n  return {\n    x: element.offsetLeft,\n    y: element.offsetTop,\n    width: width,\n    height: height\n  };\n}","import { isShadowRoot } from \"./instanceOf.js\";\nexport default function contains(parent, child) {\n  var rootNode = child.getRootNode && child.getRootNode(); // First, attempt with faster native method\n\n  if (parent.contains(child)) {\n    return true;\n  } // then fallback to custom implementation with Shadow DOM support\n  else if (rootNode && isShadowRoot(rootNode)) {\n      var next = child;\n\n      do {\n        if (next && parent.isSameNode(next)) {\n          return true;\n        } // $FlowFixMe[prop-missing]: need a better way to handle this...\n\n\n        next = next.parentNode || next.host;\n      } while (next);\n    } // Give up, the result is false\n\n\n  return false;\n}","import getWindow from \"./getWindow.js\";\nexport default function getComputedStyle(element) {\n  return getWindow(element).getComputedStyle(element);\n}","import getNodeName from \"./getNodeName.js\";\nexport default function isTableElement(element) {\n  return ['table', 'td', 'th'].indexOf(getNodeName(element)) >= 0;\n}","import { isElement } from \"./instanceOf.js\";\nexport default function getDocumentElement(element) {\n  // $FlowFixMe[incompatible-return]: assume body is always available\n  return ((isElement(element) ? element.ownerDocument : // $FlowFixMe[prop-missing]\n  element.document) || window.document).documentElement;\n}","import getNodeName from \"./getNodeName.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport { isShadowRoot } from \"./instanceOf.js\";\nexport default function getParentNode(element) {\n  if (getNodeName(element) === 'html') {\n    return element;\n  }\n\n  return (// this is a quicker (but less type safe) way to save quite some bytes from the bundle\n    // $FlowFixMe[incompatible-return]\n    // $FlowFixMe[prop-missing]\n    element.assignedSlot || // step into the shadow DOM of the parent of a slotted node\n    element.parentNode || ( // DOM Element detected\n    isShadowRoot(element) ? element.host : null) || // ShadowRoot detected\n    // $FlowFixMe[incompatible-call]: HTMLElement is a Node\n    getDocumentElement(element) // fallback\n\n  );\n}","import getWindow from \"./getWindow.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isHTMLElement, isShadowRoot } from \"./instanceOf.js\";\nimport isTableElement from \"./isTableElement.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getUAString from \"../utils/userAgent.js\";\n\nfunction getTrueOffsetParent(element) {\n  if (!isHTMLElement(element) || // https://github.com/popperjs/popper-core/issues/837\n  getComputedStyle(element).position === 'fixed') {\n    return null;\n  }\n\n  return element.offsetParent;\n} // `.offsetParent` reports `null` for fixed elements, while absolute elements\n// return the containing block\n\n\nfunction getContainingBlock(element) {\n  var isFirefox = /firefox/i.test(getUAString());\n  var isIE = /Trident/i.test(getUAString());\n\n  if (isIE && isHTMLElement(element)) {\n    // In IE 9, 10 and 11 fixed elements containing block is always established by the viewport\n    var elementCss = getComputedStyle(element);\n\n    if (elementCss.position === 'fixed') {\n      return null;\n    }\n  }\n\n  var currentNode = getParentNode(element);\n\n  if (isShadowRoot(currentNode)) {\n    currentNode = currentNode.host;\n  }\n\n  while (isHTMLElement(currentNode) && ['html', 'body'].indexOf(getNodeName(currentNode)) < 0) {\n    var css = getComputedStyle(currentNode); // This is non-exhaustive but covers the most common CSS properties that\n    // create a containing block.\n    // https://developer.mozilla.org/en-US/docs/Web/CSS/Containing_block#identifying_the_containing_block\n\n    if (css.transform !== 'none' || css.perspective !== 'none' || css.contain === 'paint' || ['transform', 'perspective'].indexOf(css.willChange) !== -1 || isFirefox && css.willChange === 'filter' || isFirefox && css.filter && css.filter !== 'none') {\n      return currentNode;\n    } else {\n      currentNode = currentNode.parentNode;\n    }\n  }\n\n  return null;\n} // Gets the closest ancestor positioned element. Handles some edge cases,\n// such as table ancestors and cross browser bugs.\n\n\nexport default function getOffsetParent(element) {\n  var window = getWindow(element);\n  var offsetParent = getTrueOffsetParent(element);\n\n  while (offsetParent && isTableElement(offsetParent) && getComputedStyle(offsetParent).position === 'static') {\n    offsetParent = getTrueOffsetParent(offsetParent);\n  }\n\n  if (offsetParent && (getNodeName(offsetParent) === 'html' || getNodeName(offsetParent) === 'body' && getComputedStyle(offsetParent).position === 'static')) {\n    return window;\n  }\n\n  return offsetParent || getContainingBlock(element) || window;\n}","export default function getMainAxisFromPlacement(placement) {\n  return ['top', 'bottom'].indexOf(placement) >= 0 ? 'x' : 'y';\n}","import { max as mathMax, min as mathMin } from \"./math.js\";\nexport function within(min, value, max) {\n  return mathMax(min, mathMin(value, max));\n}\nexport function withinMaxClamp(min, value, max) {\n  var v = within(min, value, max);\n  return v > max ? max : v;\n}","import getFreshSideObject from \"./getFreshSideObject.js\";\nexport default function mergePaddingObject(paddingObject) {\n  return Object.assign({}, getFreshSideObject(), paddingObject);\n}","export default function getFreshSideObject() {\n  return {\n    top: 0,\n    right: 0,\n    bottom: 0,\n    left: 0\n  };\n}","export default function expandToHashMap(value, keys) {\n  return keys.reduce(function (hashMap, key) {\n    hashMap[key] = value;\n    return hashMap;\n  }, {});\n}","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport contains from \"../dom-utils/contains.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport { within } from \"../utils/within.js\";\nimport mergePaddingObject from \"../utils/mergePaddingObject.js\";\nimport expandToHashMap from \"../utils/expandToHashMap.js\";\nimport { left, right, basePlacements, top, bottom } from \"../enums.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar toPaddingObject = function toPaddingObject(padding, state) {\n  padding = typeof padding === 'function' ? padding(Object.assign({}, state.rects, {\n    placement: state.placement\n  })) : padding;\n  return mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n};\n\nfunction arrow(_ref) {\n  var _state$modifiersData$;\n\n  var state = _ref.state,\n      name = _ref.name,\n      options = _ref.options;\n  var arrowElement = state.elements.arrow;\n  var popperOffsets = state.modifiersData.popperOffsets;\n  var basePlacement = getBasePlacement(state.placement);\n  var axis = getMainAxisFromPlacement(basePlacement);\n  var isVertical = [left, right].indexOf(basePlacement) >= 0;\n  var len = isVertical ? 'height' : 'width';\n\n  if (!arrowElement || !popperOffsets) {\n    return;\n  }\n\n  var paddingObject = toPaddingObject(options.padding, state);\n  var arrowRect = getLayoutRect(arrowElement);\n  var minProp = axis === 'y' ? top : left;\n  var maxProp = axis === 'y' ? bottom : right;\n  var endDiff = state.rects.reference[len] + state.rects.reference[axis] - popperOffsets[axis] - state.rects.popper[len];\n  var startDiff = popperOffsets[axis] - state.rects.reference[axis];\n  var arrowOffsetParent = getOffsetParent(arrowElement);\n  var clientSize = arrowOffsetParent ? axis === 'y' ? arrowOffsetParent.clientHeight || 0 : arrowOffsetParent.clientWidth || 0 : 0;\n  var centerToReference = endDiff / 2 - startDiff / 2; // Make sure the arrow doesn't overflow the popper if the center point is\n  // outside of the popper bounds\n\n  var min = paddingObject[minProp];\n  var max = clientSize - arrowRect[len] - paddingObject[maxProp];\n  var center = clientSize / 2 - arrowRect[len] / 2 + centerToReference;\n  var offset = within(min, center, max); // Prevents breaking syntax highlighting...\n\n  var axisProp = axis;\n  state.modifiersData[name] = (_state$modifiersData$ = {}, _state$modifiersData$[axisProp] = offset, _state$modifiersData$.centerOffset = offset - center, _state$modifiersData$);\n}\n\nfunction effect(_ref2) {\n  var state = _ref2.state,\n      options = _ref2.options;\n  var _options$element = options.element,\n      arrowElement = _options$element === void 0 ? '[data-popper-arrow]' : _options$element;\n\n  if (arrowElement == null) {\n    return;\n  } // CSS selector\n\n\n  if (typeof arrowElement === 'string') {\n    arrowElement = state.elements.popper.querySelector(arrowElement);\n\n    if (!arrowElement) {\n      return;\n    }\n  }\n\n  if (!contains(state.elements.popper, arrowElement)) {\n    return;\n  }\n\n  state.elements.arrow = arrowElement;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'arrow',\n  enabled: true,\n  phase: 'main',\n  fn: arrow,\n  effect: effect,\n  requires: ['popperOffsets'],\n  requiresIfExists: ['preventOverflow']\n};","export default function getVariation(placement) {\n  return placement.split('-')[1];\n}","import { top, left, right, bottom, end } from \"../enums.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport getWindow from \"../dom-utils/getWindow.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getComputedStyle from \"../dom-utils/getComputedStyle.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport { round } from \"../utils/math.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar unsetSides = {\n  top: 'auto',\n  right: 'auto',\n  bottom: 'auto',\n  left: 'auto'\n}; // Round the offsets to the nearest suitable subpixel based on the DPR.\n// Zooming can change the DPR, but it seems to report a value that will\n// cleanly divide the values into the appropriate subpixels.\n\nfunction roundOffsetsByDPR(_ref, win) {\n  var x = _ref.x,\n      y = _ref.y;\n  var dpr = win.devicePixelRatio || 1;\n  return {\n    x: round(x * dpr) / dpr || 0,\n    y: round(y * dpr) / dpr || 0\n  };\n}\n\nexport function mapToStyles(_ref2) {\n  var _Object$assign2;\n\n  var popper = _ref2.popper,\n      popperRect = _ref2.popperRect,\n      placement = _ref2.placement,\n      variation = _ref2.variation,\n      offsets = _ref2.offsets,\n      position = _ref2.position,\n      gpuAcceleration = _ref2.gpuAcceleration,\n      adaptive = _ref2.adaptive,\n      roundOffsets = _ref2.roundOffsets,\n      isFixed = _ref2.isFixed;\n  var _offsets$x = offsets.x,\n      x = _offsets$x === void 0 ? 0 : _offsets$x,\n      _offsets$y = offsets.y,\n      y = _offsets$y === void 0 ? 0 : _offsets$y;\n\n  var _ref3 = typeof roundOffsets === 'function' ? roundOffsets({\n    x: x,\n    y: y\n  }) : {\n    x: x,\n    y: y\n  };\n\n  x = _ref3.x;\n  y = _ref3.y;\n  var hasX = offsets.hasOwnProperty('x');\n  var hasY = offsets.hasOwnProperty('y');\n  var sideX = left;\n  var sideY = top;\n  var win = window;\n\n  if (adaptive) {\n    var offsetParent = getOffsetParent(popper);\n    var heightProp = 'clientHeight';\n    var widthProp = 'clientWidth';\n\n    if (offsetParent === getWindow(popper)) {\n      offsetParent = getDocumentElement(popper);\n\n      if (getComputedStyle(offsetParent).position !== 'static' && position === 'absolute') {\n        heightProp = 'scrollHeight';\n        widthProp = 'scrollWidth';\n      }\n    } // $FlowFixMe[incompatible-cast]: force type refinement, we compare offsetParent with window above, but Flow doesn't detect it\n\n\n    offsetParent = offsetParent;\n\n    if (placement === top || (placement === left || placement === right) && variation === end) {\n      sideY = bottom;\n      var offsetY = isFixed && offsetParent === win && win.visualViewport ? win.visualViewport.height : // $FlowFixMe[prop-missing]\n      offsetParent[heightProp];\n      y -= offsetY - popperRect.height;\n      y *= gpuAcceleration ? 1 : -1;\n    }\n\n    if (placement === left || (placement === top || placement === bottom) && variation === end) {\n      sideX = right;\n      var offsetX = isFixed && offsetParent === win && win.visualViewport ? win.visualViewport.width : // $FlowFixMe[prop-missing]\n      offsetParent[widthProp];\n      x -= offsetX - popperRect.width;\n      x *= gpuAcceleration ? 1 : -1;\n    }\n  }\n\n  var commonStyles = Object.assign({\n    position: position\n  }, adaptive && unsetSides);\n\n  var _ref4 = roundOffsets === true ? roundOffsetsByDPR({\n    x: x,\n    y: y\n  }, getWindow(popper)) : {\n    x: x,\n    y: y\n  };\n\n  x = _ref4.x;\n  y = _ref4.y;\n\n  if (gpuAcceleration) {\n    var _Object$assign;\n\n    return Object.assign({}, commonStyles, (_Object$assign = {}, _Object$assign[sideY] = hasY ? '0' : '', _Object$assign[sideX] = hasX ? '0' : '', _Object$assign.transform = (win.devicePixelRatio || 1) <= 1 ? \"translate(\" + x + \"px, \" + y + \"px)\" : \"translate3d(\" + x + \"px, \" + y + \"px, 0)\", _Object$assign));\n  }\n\n  return Object.assign({}, commonStyles, (_Object$assign2 = {}, _Object$assign2[sideY] = hasY ? y + \"px\" : '', _Object$assign2[sideX] = hasX ? x + \"px\" : '', _Object$assign2.transform = '', _Object$assign2));\n}\n\nfunction computeStyles(_ref5) {\n  var state = _ref5.state,\n      options = _ref5.options;\n  var _options$gpuAccelerat = options.gpuAcceleration,\n      gpuAcceleration = _options$gpuAccelerat === void 0 ? true : _options$gpuAccelerat,\n      _options$adaptive = options.adaptive,\n      adaptive = _options$adaptive === void 0 ? true : _options$adaptive,\n      _options$roundOffsets = options.roundOffsets,\n      roundOffsets = _options$roundOffsets === void 0 ? true : _options$roundOffsets;\n  var commonStyles = {\n    placement: getBasePlacement(state.placement),\n    variation: getVariation(state.placement),\n    popper: state.elements.popper,\n    popperRect: state.rects.popper,\n    gpuAcceleration: gpuAcceleration,\n    isFixed: state.options.strategy === 'fixed'\n  };\n\n  if (state.modifiersData.popperOffsets != null) {\n    state.styles.popper = Object.assign({}, state.styles.popper, mapToStyles(Object.assign({}, commonStyles, {\n      offsets: state.modifiersData.popperOffsets,\n      position: state.options.strategy,\n      adaptive: adaptive,\n      roundOffsets: roundOffsets\n    })));\n  }\n\n  if (state.modifiersData.arrow != null) {\n    state.styles.arrow = Object.assign({}, state.styles.arrow, mapToStyles(Object.assign({}, commonStyles, {\n      offsets: state.modifiersData.arrow,\n      position: 'absolute',\n      adaptive: false,\n      roundOffsets: roundOffsets\n    })));\n  }\n\n  state.attributes.popper = Object.assign({}, state.attributes.popper, {\n    'data-popper-placement': state.placement\n  });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'computeStyles',\n  enabled: true,\n  phase: 'beforeWrite',\n  fn: computeStyles,\n  data: {}\n};","import getWindow from \"../dom-utils/getWindow.js\"; // eslint-disable-next-line import/no-unused-modules\n\nvar passive = {\n  passive: true\n};\n\nfunction effect(_ref) {\n  var state = _ref.state,\n      instance = _ref.instance,\n      options = _ref.options;\n  var _options$scroll = options.scroll,\n      scroll = _options$scroll === void 0 ? true : _options$scroll,\n      _options$resize = options.resize,\n      resize = _options$resize === void 0 ? true : _options$resize;\n  var window = getWindow(state.elements.popper);\n  var scrollParents = [].concat(state.scrollParents.reference, state.scrollParents.popper);\n\n  if (scroll) {\n    scrollParents.forEach(function (scrollParent) {\n      scrollParent.addEventListener('scroll', instance.update, passive);\n    });\n  }\n\n  if (resize) {\n    window.addEventListener('resize', instance.update, passive);\n  }\n\n  return function () {\n    if (scroll) {\n      scrollParents.forEach(function (scrollParent) {\n        scrollParent.removeEventListener('scroll', instance.update, passive);\n      });\n    }\n\n    if (resize) {\n      window.removeEventListener('resize', instance.update, passive);\n    }\n  };\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'eventListeners',\n  enabled: true,\n  phase: 'write',\n  fn: function fn() {},\n  effect: effect,\n  data: {}\n};","var hash = {\n  left: 'right',\n  right: 'left',\n  bottom: 'top',\n  top: 'bottom'\n};\nexport default function getOppositePlacement(placement) {\n  return placement.replace(/left|right|bottom|top/g, function (matched) {\n    return hash[matched];\n  });\n}","var hash = {\n  start: 'end',\n  end: 'start'\n};\nexport default function getOppositeVariationPlacement(placement) {\n  return placement.replace(/start|end/g, function (matched) {\n    return hash[matched];\n  });\n}","import getWindow from \"./getWindow.js\";\nexport default function getWindowScroll(node) {\n  var win = getWindow(node);\n  var scrollLeft = win.pageXOffset;\n  var scrollTop = win.pageYOffset;\n  return {\n    scrollLeft: scrollLeft,\n    scrollTop: scrollTop\n  };\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nexport default function getWindowScrollBarX(element) {\n  // If <html> has a CSS width greater than the viewport, then this will be\n  // incorrect for RTL.\n  // Popper 1 is broken in this case and never had a bug report so let's assume\n  // it's not an issue. I don't think anyone ever specifies width on <html>\n  // anyway.\n  // Browsers where the left scrollbar doesn't cause an issue report `0` for\n  // this (e.g. Edge 2019, IE11, Safari)\n  return getBoundingClientRect(getDocumentElement(element)).left + getWindowScroll(element).scrollLeft;\n}","import getComputedStyle from \"./getComputedStyle.js\";\nexport default function isScrollParent(element) {\n  // Firefox wants us to check `-x` and `-y` variations as well\n  var _getComputedStyle = getComputedStyle(element),\n      overflow = _getComputedStyle.overflow,\n      overflowX = _getComputedStyle.overflowX,\n      overflowY = _getComputedStyle.overflowY;\n\n  return /auto|scroll|overlay|hidden/.test(overflow + overflowY + overflowX);\n}","import getParentNode from \"./getParentNode.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nexport default function getScrollParent(node) {\n  if (['html', 'body', '#document'].indexOf(getNodeName(node)) >= 0) {\n    // $FlowFixMe[incompatible-return]: assume body is always available\n    return node.ownerDocument.body;\n  }\n\n  if (isHTMLElement(node) && isScrollParent(node)) {\n    return node;\n  }\n\n  return getScrollParent(getParentNode(node));\n}","import getScrollParent from \"./getScrollParent.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport getWindow from \"./getWindow.js\";\nimport isScrollParent from \"./isScrollParent.js\";\n/*\ngiven a DOM element, return the list of all scroll parents, up the list of ancesors\nuntil we get to the top window object. This list is what we attach scroll listeners\nto, because if any of these parent elements scroll, we'll need to re-calculate the\nreference element's position.\n*/\n\nexport default function listScrollParents(element, list) {\n  var _element$ownerDocumen;\n\n  if (list === void 0) {\n    list = [];\n  }\n\n  var scrollParent = getScrollParent(element);\n  var isBody = scrollParent === ((_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body);\n  var win = getWindow(scrollParent);\n  var target = isBody ? [win].concat(win.visualViewport || [], isScrollParent(scrollParent) ? scrollParent : []) : scrollParent;\n  var updatedList = list.concat(target);\n  return isBody ? updatedList : // $FlowFixMe[incompatible-call]: isBody tells us target will be an HTMLElement here\n  updatedList.concat(listScrollParents(getParentNode(target)));\n}","export default function rectToClientRect(rect) {\n  return Object.assign({}, rect, {\n    left: rect.x,\n    top: rect.y,\n    right: rect.x + rect.width,\n    bottom: rect.y + rect.height\n  });\n}","import { viewport } from \"../enums.js\";\nimport getViewportRect from \"./getViewportRect.js\";\nimport getDocumentRect from \"./getDocumentRect.js\";\nimport listScrollParents from \"./listScrollParents.js\";\nimport getOffsetParent from \"./getOffsetParent.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport { isElement, isHTMLElement } from \"./instanceOf.js\";\nimport getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getParentNode from \"./getParentNode.js\";\nimport contains from \"./contains.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport rectToClientRect from \"../utils/rectToClientRect.js\";\nimport { max, min } from \"../utils/math.js\";\n\nfunction getInnerBoundingClientRect(element, strategy) {\n  var rect = getBoundingClientRect(element, false, strategy === 'fixed');\n  rect.top = rect.top + element.clientTop;\n  rect.left = rect.left + element.clientLeft;\n  rect.bottom = rect.top + element.clientHeight;\n  rect.right = rect.left + element.clientWidth;\n  rect.width = element.clientWidth;\n  rect.height = element.clientHeight;\n  rect.x = rect.left;\n  rect.y = rect.top;\n  return rect;\n}\n\nfunction getClientRectFromMixedType(element, clippingParent, strategy) {\n  return clippingParent === viewport ? rectToClientRect(getViewportRect(element, strategy)) : isElement(clippingParent) ? getInnerBoundingClientRect(clippingParent, strategy) : rectToClientRect(getDocumentRect(getDocumentElement(element)));\n} // A \"clipping parent\" is an overflowable container with the characteristic of\n// clipping (or hiding) overflowing elements with a position different from\n// `initial`\n\n\nfunction getClippingParents(element) {\n  var clippingParents = listScrollParents(getParentNode(element));\n  var canEscapeClipping = ['absolute', 'fixed'].indexOf(getComputedStyle(element).position) >= 0;\n  var clipperElement = canEscapeClipping && isHTMLElement(element) ? getOffsetParent(element) : element;\n\n  if (!isElement(clipperElement)) {\n    return [];\n  } // $FlowFixMe[incompatible-return]: https://github.com/facebook/flow/issues/1414\n\n\n  return clippingParents.filter(function (clippingParent) {\n    return isElement(clippingParent) && contains(clippingParent, clipperElement) && getNodeName(clippingParent) !== 'body';\n  });\n} // Gets the maximum area that the element is visible in due to any number of\n// clipping parents\n\n\nexport default function getClippingRect(element, boundary, rootBoundary, strategy) {\n  var mainClippingParents = boundary === 'clippingParents' ? getClippingParents(element) : [].concat(boundary);\n  var clippingParents = [].concat(mainClippingParents, [rootBoundary]);\n  var firstClippingParent = clippingParents[0];\n  var clippingRect = clippingParents.reduce(function (accRect, clippingParent) {\n    var rect = getClientRectFromMixedType(element, clippingParent, strategy);\n    accRect.top = max(rect.top, accRect.top);\n    accRect.right = min(rect.right, accRect.right);\n    accRect.bottom = min(rect.bottom, accRect.bottom);\n    accRect.left = max(rect.left, accRect.left);\n    return accRect;\n  }, getClientRectFromMixedType(element, firstClippingParent, strategy));\n  clippingRect.width = clippingRect.right - clippingRect.left;\n  clippingRect.height = clippingRect.bottom - clippingRect.top;\n  clippingRect.x = clippingRect.left;\n  clippingRect.y = clippingRect.top;\n  return clippingRect;\n}","import getWindow from \"./getWindow.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport isLayoutViewport from \"./isLayoutViewport.js\";\nexport default function getViewportRect(element, strategy) {\n  var win = getWindow(element);\n  var html = getDocumentElement(element);\n  var visualViewport = win.visualViewport;\n  var width = html.clientWidth;\n  var height = html.clientHeight;\n  var x = 0;\n  var y = 0;\n\n  if (visualViewport) {\n    width = visualViewport.width;\n    height = visualViewport.height;\n    var layoutViewport = isLayoutViewport();\n\n    if (layoutViewport || !layoutViewport && strategy === 'fixed') {\n      x = visualViewport.offsetLeft;\n      y = visualViewport.offsetTop;\n    }\n  }\n\n  return {\n    width: width,\n    height: height,\n    x: x + getWindowScrollBarX(element),\n    y: y\n  };\n}","import getDocumentElement from \"./getDocumentElement.js\";\nimport getComputedStyle from \"./getComputedStyle.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getWindowScroll from \"./getWindowScroll.js\";\nimport { max } from \"../utils/math.js\"; // Gets the entire size of the scrollable document area, even extending outside\n// of the `<html>` and `<body>` rect bounds if horizontally scrollable\n\nexport default function getDocumentRect(element) {\n  var _element$ownerDocumen;\n\n  var html = getDocumentElement(element);\n  var winScroll = getWindowScroll(element);\n  var body = (_element$ownerDocumen = element.ownerDocument) == null ? void 0 : _element$ownerDocumen.body;\n  var width = max(html.scrollWidth, html.clientWidth, body ? body.scrollWidth : 0, body ? body.clientWidth : 0);\n  var height = max(html.scrollHeight, html.clientHeight, body ? body.scrollHeight : 0, body ? body.clientHeight : 0);\n  var x = -winScroll.scrollLeft + getWindowScrollBarX(element);\n  var y = -winScroll.scrollTop;\n\n  if (getComputedStyle(body || html).direction === 'rtl') {\n    x += max(html.clientWidth, body ? body.clientWidth : 0) - width;\n  }\n\n  return {\n    width: width,\n    height: height,\n    x: x,\n    y: y\n  };\n}","import getBasePlacement from \"./getBasePlacement.js\";\nimport getVariation from \"./getVariation.js\";\nimport getMainAxisFromPlacement from \"./getMainAxisFromPlacement.js\";\nimport { top, right, bottom, left, start, end } from \"../enums.js\";\nexport default function computeOffsets(_ref) {\n  var reference = _ref.reference,\n      element = _ref.element,\n      placement = _ref.placement;\n  var basePlacement = placement ? getBasePlacement(placement) : null;\n  var variation = placement ? getVariation(placement) : null;\n  var commonX = reference.x + reference.width / 2 - element.width / 2;\n  var commonY = reference.y + reference.height / 2 - element.height / 2;\n  var offsets;\n\n  switch (basePlacement) {\n    case top:\n      offsets = {\n        x: commonX,\n        y: reference.y - element.height\n      };\n      break;\n\n    case bottom:\n      offsets = {\n        x: commonX,\n        y: reference.y + reference.height\n      };\n      break;\n\n    case right:\n      offsets = {\n        x: reference.x + reference.width,\n        y: commonY\n      };\n      break;\n\n    case left:\n      offsets = {\n        x: reference.x - element.width,\n        y: commonY\n      };\n      break;\n\n    default:\n      offsets = {\n        x: reference.x,\n        y: reference.y\n      };\n  }\n\n  var mainAxis = basePlacement ? getMainAxisFromPlacement(basePlacement) : null;\n\n  if (mainAxis != null) {\n    var len = mainAxis === 'y' ? 'height' : 'width';\n\n    switch (variation) {\n      case start:\n        offsets[mainAxis] = offsets[mainAxis] - (reference[len] / 2 - element[len] / 2);\n        break;\n\n      case end:\n        offsets[mainAxis] = offsets[mainAxis] + (reference[len] / 2 - element[len] / 2);\n        break;\n\n      default:\n    }\n  }\n\n  return offsets;\n}","import getClippingRect from \"../dom-utils/getClippingRect.js\";\nimport getDocumentElement from \"../dom-utils/getDocumentElement.js\";\nimport getBoundingClientRect from \"../dom-utils/getBoundingClientRect.js\";\nimport computeOffsets from \"./computeOffsets.js\";\nimport rectToClientRect from \"./rectToClientRect.js\";\nimport { clippingParents, reference, popper, bottom, top, right, basePlacements, viewport } from \"../enums.js\";\nimport { isElement } from \"../dom-utils/instanceOf.js\";\nimport mergePaddingObject from \"./mergePaddingObject.js\";\nimport expandToHashMap from \"./expandToHashMap.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport default function detectOverflow(state, options) {\n  if (options === void 0) {\n    options = {};\n  }\n\n  var _options = options,\n      _options$placement = _options.placement,\n      placement = _options$placement === void 0 ? state.placement : _options$placement,\n      _options$strategy = _options.strategy,\n      strategy = _options$strategy === void 0 ? state.strategy : _options$strategy,\n      _options$boundary = _options.boundary,\n      boundary = _options$boundary === void 0 ? clippingParents : _options$boundary,\n      _options$rootBoundary = _options.rootBoundary,\n      rootBoundary = _options$rootBoundary === void 0 ? viewport : _options$rootBoundary,\n      _options$elementConte = _options.elementContext,\n      elementContext = _options$elementConte === void 0 ? popper : _options$elementConte,\n      _options$altBoundary = _options.altBoundary,\n      altBoundary = _options$altBoundary === void 0 ? false : _options$altBoundary,\n      _options$padding = _options.padding,\n      padding = _options$padding === void 0 ? 0 : _options$padding;\n  var paddingObject = mergePaddingObject(typeof padding !== 'number' ? padding : expandToHashMap(padding, basePlacements));\n  var altContext = elementContext === popper ? reference : popper;\n  var popperRect = state.rects.popper;\n  var element = state.elements[altBoundary ? altContext : elementContext];\n  var clippingClientRect = getClippingRect(isElement(element) ? element : element.contextElement || getDocumentElement(state.elements.popper), boundary, rootBoundary, strategy);\n  var referenceClientRect = getBoundingClientRect(state.elements.reference);\n  var popperOffsets = computeOffsets({\n    reference: referenceClientRect,\n    element: popperRect,\n    strategy: 'absolute',\n    placement: placement\n  });\n  var popperClientRect = rectToClientRect(Object.assign({}, popperRect, popperOffsets));\n  var elementClientRect = elementContext === popper ? popperClientRect : referenceClientRect; // positive = overflowing the clipping rect\n  // 0 or negative = within the clipping rect\n\n  var overflowOffsets = {\n    top: clippingClientRect.top - elementClientRect.top + paddingObject.top,\n    bottom: elementClientRect.bottom - clippingClientRect.bottom + paddingObject.bottom,\n    left: clippingClientRect.left - elementClientRect.left + paddingObject.left,\n    right: elementClientRect.right - clippingClientRect.right + paddingObject.right\n  };\n  var offsetData = state.modifiersData.offset; // Offsets can be applied only to the popper element\n\n  if (elementContext === popper && offsetData) {\n    var offset = offsetData[placement];\n    Object.keys(overflowOffsets).forEach(function (key) {\n      var multiply = [right, bottom].indexOf(key) >= 0 ? 1 : -1;\n      var axis = [top, bottom].indexOf(key) >= 0 ? 'y' : 'x';\n      overflowOffsets[key] += offset[axis] * multiply;\n    });\n  }\n\n  return overflowOffsets;\n}","import getVariation from \"./getVariation.js\";\nimport { variationPlacements, basePlacements, placements as allPlacements } from \"../enums.js\";\nimport detectOverflow from \"./detectOverflow.js\";\nimport getBasePlacement from \"./getBasePlacement.js\";\nexport default function computeAutoPlacement(state, options) {\n  if (options === void 0) {\n    options = {};\n  }\n\n  var _options = options,\n      placement = _options.placement,\n      boundary = _options.boundary,\n      rootBoundary = _options.rootBoundary,\n      padding = _options.padding,\n      flipVariations = _options.flipVariations,\n      _options$allowedAutoP = _options.allowedAutoPlacements,\n      allowedAutoPlacements = _options$allowedAutoP === void 0 ? allPlacements : _options$allowedAutoP;\n  var variation = getVariation(placement);\n  var placements = variation ? flipVariations ? variationPlacements : variationPlacements.filter(function (placement) {\n    return getVariation(placement) === variation;\n  }) : basePlacements;\n  var allowedPlacements = placements.filter(function (placement) {\n    return allowedAutoPlacements.indexOf(placement) >= 0;\n  });\n\n  if (allowedPlacements.length === 0) {\n    allowedPlacements = placements;\n  } // $FlowFixMe[incompatible-type]: Flow seems to have problems with two array unions...\n\n\n  var overflows = allowedPlacements.reduce(function (acc, placement) {\n    acc[placement] = detectOverflow(state, {\n      placement: placement,\n      boundary: boundary,\n      rootBoundary: rootBoundary,\n      padding: padding\n    })[getBasePlacement(placement)];\n    return acc;\n  }, {});\n  return Object.keys(overflows).sort(function (a, b) {\n    return overflows[a] - overflows[b];\n  });\n}","import getOppositePlacement from \"../utils/getOppositePlacement.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getOppositeVariationPlacement from \"../utils/getOppositeVariationPlacement.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport computeAutoPlacement from \"../utils/computeAutoPlacement.js\";\nimport { bottom, top, start, right, left, auto } from \"../enums.js\";\nimport getVariation from \"../utils/getVariation.js\"; // eslint-disable-next-line import/no-unused-modules\n\nfunction getExpandedFallbackPlacements(placement) {\n  if (getBasePlacement(placement) === auto) {\n    return [];\n  }\n\n  var oppositePlacement = getOppositePlacement(placement);\n  return [getOppositeVariationPlacement(placement), oppositePlacement, getOppositeVariationPlacement(oppositePlacement)];\n}\n\nfunction flip(_ref) {\n  var state = _ref.state,\n      options = _ref.options,\n      name = _ref.name;\n\n  if (state.modifiersData[name]._skip) {\n    return;\n  }\n\n  var _options$mainAxis = options.mainAxis,\n      checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n      _options$altAxis = options.altAxis,\n      checkAltAxis = _options$altAxis === void 0 ? true : _options$altAxis,\n      specifiedFallbackPlacements = options.fallbackPlacements,\n      padding = options.padding,\n      boundary = options.boundary,\n      rootBoundary = options.rootBoundary,\n      altBoundary = options.altBoundary,\n      _options$flipVariatio = options.flipVariations,\n      flipVariations = _options$flipVariatio === void 0 ? true : _options$flipVariatio,\n      allowedAutoPlacements = options.allowedAutoPlacements;\n  var preferredPlacement = state.options.placement;\n  var basePlacement = getBasePlacement(preferredPlacement);\n  var isBasePlacement = basePlacement === preferredPlacement;\n  var fallbackPlacements = specifiedFallbackPlacements || (isBasePlacement || !flipVariations ? [getOppositePlacement(preferredPlacement)] : getExpandedFallbackPlacements(preferredPlacement));\n  var placements = [preferredPlacement].concat(fallbackPlacements).reduce(function (acc, placement) {\n    return acc.concat(getBasePlacement(placement) === auto ? computeAutoPlacement(state, {\n      placement: placement,\n      boundary: boundary,\n      rootBoundary: rootBoundary,\n      padding: padding,\n      flipVariations: flipVariations,\n      allowedAutoPlacements: allowedAutoPlacements\n    }) : placement);\n  }, []);\n  var referenceRect = state.rects.reference;\n  var popperRect = state.rects.popper;\n  var checksMap = new Map();\n  var makeFallbackChecks = true;\n  var firstFittingPlacement = placements[0];\n\n  for (var i = 0; i < placements.length; i++) {\n    var placement = placements[i];\n\n    var _basePlacement = getBasePlacement(placement);\n\n    var isStartVariation = getVariation(placement) === start;\n    var isVertical = [top, bottom].indexOf(_basePlacement) >= 0;\n    var len = isVertical ? 'width' : 'height';\n    var overflow = detectOverflow(state, {\n      placement: placement,\n      boundary: boundary,\n      rootBoundary: rootBoundary,\n      altBoundary: altBoundary,\n      padding: padding\n    });\n    var mainVariationSide = isVertical ? isStartVariation ? right : left : isStartVariation ? bottom : top;\n\n    if (referenceRect[len] > popperRect[len]) {\n      mainVariationSide = getOppositePlacement(mainVariationSide);\n    }\n\n    var altVariationSide = getOppositePlacement(mainVariationSide);\n    var checks = [];\n\n    if (checkMainAxis) {\n      checks.push(overflow[_basePlacement] <= 0);\n    }\n\n    if (checkAltAxis) {\n      checks.push(overflow[mainVariationSide] <= 0, overflow[altVariationSide] <= 0);\n    }\n\n    if (checks.every(function (check) {\n      return check;\n    })) {\n      firstFittingPlacement = placement;\n      makeFallbackChecks = false;\n      break;\n    }\n\n    checksMap.set(placement, checks);\n  }\n\n  if (makeFallbackChecks) {\n    // `2` may be desired in some cases – research later\n    var numberOfChecks = flipVariations ? 3 : 1;\n\n    var _loop = function _loop(_i) {\n      var fittingPlacement = placements.find(function (placement) {\n        var checks = checksMap.get(placement);\n\n        if (checks) {\n          return checks.slice(0, _i).every(function (check) {\n            return check;\n          });\n        }\n      });\n\n      if (fittingPlacement) {\n        firstFittingPlacement = fittingPlacement;\n        return \"break\";\n      }\n    };\n\n    for (var _i = numberOfChecks; _i > 0; _i--) {\n      var _ret = _loop(_i);\n\n      if (_ret === \"break\") break;\n    }\n  }\n\n  if (state.placement !== firstFittingPlacement) {\n    state.modifiersData[name]._skip = true;\n    state.placement = firstFittingPlacement;\n    state.reset = true;\n  }\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'flip',\n  enabled: true,\n  phase: 'main',\n  fn: flip,\n  requiresIfExists: ['offset'],\n  data: {\n    _skip: false\n  }\n};","import { top, bottom, left, right } from \"../enums.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\n\nfunction getSideOffsets(overflow, rect, preventedOffsets) {\n  if (preventedOffsets === void 0) {\n    preventedOffsets = {\n      x: 0,\n      y: 0\n    };\n  }\n\n  return {\n    top: overflow.top - rect.height - preventedOffsets.y,\n    right: overflow.right - rect.width + preventedOffsets.x,\n    bottom: overflow.bottom - rect.height + preventedOffsets.y,\n    left: overflow.left - rect.width - preventedOffsets.x\n  };\n}\n\nfunction isAnySideFullyClipped(overflow) {\n  return [top, right, bottom, left].some(function (side) {\n    return overflow[side] >= 0;\n  });\n}\n\nfunction hide(_ref) {\n  var state = _ref.state,\n      name = _ref.name;\n  var referenceRect = state.rects.reference;\n  var popperRect = state.rects.popper;\n  var preventedOffsets = state.modifiersData.preventOverflow;\n  var referenceOverflow = detectOverflow(state, {\n    elementContext: 'reference'\n  });\n  var popperAltOverflow = detectOverflow(state, {\n    altBoundary: true\n  });\n  var referenceClippingOffsets = getSideOffsets(referenceOverflow, referenceRect);\n  var popperEscapeOffsets = getSideOffsets(popperAltOverflow, popperRect, preventedOffsets);\n  var isReferenceHidden = isAnySideFullyClipped(referenceClippingOffsets);\n  var hasPopperEscaped = isAnySideFullyClipped(popperEscapeOffsets);\n  state.modifiersData[name] = {\n    referenceClippingOffsets: referenceClippingOffsets,\n    popperEscapeOffsets: popperEscapeOffsets,\n    isReferenceHidden: isReferenceHidden,\n    hasPopperEscaped: hasPopperEscaped\n  };\n  state.attributes.popper = Object.assign({}, state.attributes.popper, {\n    'data-popper-reference-hidden': isReferenceHidden,\n    'data-popper-escaped': hasPopperEscaped\n  });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'hide',\n  enabled: true,\n  phase: 'main',\n  requiresIfExists: ['preventOverflow'],\n  fn: hide\n};","import getBasePlacement from \"../utils/getBasePlacement.js\";\nimport { top, left, right, placements } from \"../enums.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport function distanceAndSkiddingToXY(placement, rects, offset) {\n  var basePlacement = getBasePlacement(placement);\n  var invertDistance = [left, top].indexOf(basePlacement) >= 0 ? -1 : 1;\n\n  var _ref = typeof offset === 'function' ? offset(Object.assign({}, rects, {\n    placement: placement\n  })) : offset,\n      skidding = _ref[0],\n      distance = _ref[1];\n\n  skidding = skidding || 0;\n  distance = (distance || 0) * invertDistance;\n  return [left, right].indexOf(basePlacement) >= 0 ? {\n    x: distance,\n    y: skidding\n  } : {\n    x: skidding,\n    y: distance\n  };\n}\n\nfunction offset(_ref2) {\n  var state = _ref2.state,\n      options = _ref2.options,\n      name = _ref2.name;\n  var _options$offset = options.offset,\n      offset = _options$offset === void 0 ? [0, 0] : _options$offset;\n  var data = placements.reduce(function (acc, placement) {\n    acc[placement] = distanceAndSkiddingToXY(placement, state.rects, offset);\n    return acc;\n  }, {});\n  var _data$state$placement = data[state.placement],\n      x = _data$state$placement.x,\n      y = _data$state$placement.y;\n\n  if (state.modifiersData.popperOffsets != null) {\n    state.modifiersData.popperOffsets.x += x;\n    state.modifiersData.popperOffsets.y += y;\n  }\n\n  state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'offset',\n  enabled: true,\n  phase: 'main',\n  requires: ['popperOffsets'],\n  fn: offset\n};","import computeOffsets from \"../utils/computeOffsets.js\";\n\nfunction popperOffsets(_ref) {\n  var state = _ref.state,\n      name = _ref.name;\n  // Offsets are the actual position the popper needs to have to be\n  // properly positioned near its reference element\n  // This is the most basic placement, and will be adjusted by\n  // the modifiers in the next step\n  state.modifiersData[name] = computeOffsets({\n    reference: state.rects.reference,\n    element: state.rects.popper,\n    strategy: 'absolute',\n    placement: state.placement\n  });\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'popperOffsets',\n  enabled: true,\n  phase: 'read',\n  fn: popperOffsets,\n  data: {}\n};","import { top, left, right, bottom, start } from \"../enums.js\";\nimport getBasePlacement from \"../utils/getBasePlacement.js\";\nimport getMainAxisFromPlacement from \"../utils/getMainAxisFromPlacement.js\";\nimport getAltAxis from \"../utils/getAltAxis.js\";\nimport { within, withinMaxClamp } from \"../utils/within.js\";\nimport getLayoutRect from \"../dom-utils/getLayoutRect.js\";\nimport getOffsetParent from \"../dom-utils/getOffsetParent.js\";\nimport detectOverflow from \"../utils/detectOverflow.js\";\nimport getVariation from \"../utils/getVariation.js\";\nimport getFreshSideObject from \"../utils/getFreshSideObject.js\";\nimport { min as mathMin, max as mathMax } from \"../utils/math.js\";\n\nfunction preventOverflow(_ref) {\n  var state = _ref.state,\n      options = _ref.options,\n      name = _ref.name;\n  var _options$mainAxis = options.mainAxis,\n      checkMainAxis = _options$mainAxis === void 0 ? true : _options$mainAxis,\n      _options$altAxis = options.altAxis,\n      checkAltAxis = _options$altAxis === void 0 ? false : _options$altAxis,\n      boundary = options.boundary,\n      rootBoundary = options.rootBoundary,\n      altBoundary = options.altBoundary,\n      padding = options.padding,\n      _options$tether = options.tether,\n      tether = _options$tether === void 0 ? true : _options$tether,\n      _options$tetherOffset = options.tetherOffset,\n      tetherOffset = _options$tetherOffset === void 0 ? 0 : _options$tetherOffset;\n  var overflow = detectOverflow(state, {\n    boundary: boundary,\n    rootBoundary: rootBoundary,\n    padding: padding,\n    altBoundary: altBoundary\n  });\n  var basePlacement = getBasePlacement(state.placement);\n  var variation = getVariation(state.placement);\n  var isBasePlacement = !variation;\n  var mainAxis = getMainAxisFromPlacement(basePlacement);\n  var altAxis = getAltAxis(mainAxis);\n  var popperOffsets = state.modifiersData.popperOffsets;\n  var referenceRect = state.rects.reference;\n  var popperRect = state.rects.popper;\n  var tetherOffsetValue = typeof tetherOffset === 'function' ? tetherOffset(Object.assign({}, state.rects, {\n    placement: state.placement\n  })) : tetherOffset;\n  var normalizedTetherOffsetValue = typeof tetherOffsetValue === 'number' ? {\n    mainAxis: tetherOffsetValue,\n    altAxis: tetherOffsetValue\n  } : Object.assign({\n    mainAxis: 0,\n    altAxis: 0\n  }, tetherOffsetValue);\n  var offsetModifierState = state.modifiersData.offset ? state.modifiersData.offset[state.placement] : null;\n  var data = {\n    x: 0,\n    y: 0\n  };\n\n  if (!popperOffsets) {\n    return;\n  }\n\n  if (checkMainAxis) {\n    var _offsetModifierState$;\n\n    var mainSide = mainAxis === 'y' ? top : left;\n    var altSide = mainAxis === 'y' ? bottom : right;\n    var len = mainAxis === 'y' ? 'height' : 'width';\n    var offset = popperOffsets[mainAxis];\n    var min = offset + overflow[mainSide];\n    var max = offset - overflow[altSide];\n    var additive = tether ? -popperRect[len] / 2 : 0;\n    var minLen = variation === start ? referenceRect[len] : popperRect[len];\n    var maxLen = variation === start ? -popperRect[len] : -referenceRect[len]; // We need to include the arrow in the calculation so the arrow doesn't go\n    // outside the reference bounds\n\n    var arrowElement = state.elements.arrow;\n    var arrowRect = tether && arrowElement ? getLayoutRect(arrowElement) : {\n      width: 0,\n      height: 0\n    };\n    var arrowPaddingObject = state.modifiersData['arrow#persistent'] ? state.modifiersData['arrow#persistent'].padding : getFreshSideObject();\n    var arrowPaddingMin = arrowPaddingObject[mainSide];\n    var arrowPaddingMax = arrowPaddingObject[altSide]; // If the reference length is smaller than the arrow length, we don't want\n    // to include its full size in the calculation. If the reference is small\n    // and near the edge of a boundary, the popper can overflow even if the\n    // reference is not overflowing as well (e.g. virtual elements with no\n    // width or height)\n\n    var arrowLen = within(0, referenceRect[len], arrowRect[len]);\n    var minOffset = isBasePlacement ? referenceRect[len] / 2 - additive - arrowLen - arrowPaddingMin - normalizedTetherOffsetValue.mainAxis : minLen - arrowLen - arrowPaddingMin - normalizedTetherOffsetValue.mainAxis;\n    var maxOffset = isBasePlacement ? -referenceRect[len] / 2 + additive + arrowLen + arrowPaddingMax + normalizedTetherOffsetValue.mainAxis : maxLen + arrowLen + arrowPaddingMax + normalizedTetherOffsetValue.mainAxis;\n    var arrowOffsetParent = state.elements.arrow && getOffsetParent(state.elements.arrow);\n    var clientOffset = arrowOffsetParent ? mainAxis === 'y' ? arrowOffsetParent.clientTop || 0 : arrowOffsetParent.clientLeft || 0 : 0;\n    var offsetModifierValue = (_offsetModifierState$ = offsetModifierState == null ? void 0 : offsetModifierState[mainAxis]) != null ? _offsetModifierState$ : 0;\n    var tetherMin = offset + minOffset - offsetModifierValue - clientOffset;\n    var tetherMax = offset + maxOffset - offsetModifierValue;\n    var preventedOffset = within(tether ? mathMin(min, tetherMin) : min, offset, tether ? mathMax(max, tetherMax) : max);\n    popperOffsets[mainAxis] = preventedOffset;\n    data[mainAxis] = preventedOffset - offset;\n  }\n\n  if (checkAltAxis) {\n    var _offsetModifierState$2;\n\n    var _mainSide = mainAxis === 'x' ? top : left;\n\n    var _altSide = mainAxis === 'x' ? bottom : right;\n\n    var _offset = popperOffsets[altAxis];\n\n    var _len = altAxis === 'y' ? 'height' : 'width';\n\n    var _min = _offset + overflow[_mainSide];\n\n    var _max = _offset - overflow[_altSide];\n\n    var isOriginSide = [top, left].indexOf(basePlacement) !== -1;\n\n    var _offsetModifierValue = (_offsetModifierState$2 = offsetModifierState == null ? void 0 : offsetModifierState[altAxis]) != null ? _offsetModifierState$2 : 0;\n\n    var _tetherMin = isOriginSide ? _min : _offset - referenceRect[_len] - popperRect[_len] - _offsetModifierValue + normalizedTetherOffsetValue.altAxis;\n\n    var _tetherMax = isOriginSide ? _offset + referenceRect[_len] + popperRect[_len] - _offsetModifierValue - normalizedTetherOffsetValue.altAxis : _max;\n\n    var _preventedOffset = tether && isOriginSide ? withinMaxClamp(_tetherMin, _offset, _tetherMax) : within(tether ? _tetherMin : _min, _offset, tether ? _tetherMax : _max);\n\n    popperOffsets[altAxis] = _preventedOffset;\n    data[altAxis] = _preventedOffset - _offset;\n  }\n\n  state.modifiersData[name] = data;\n} // eslint-disable-next-line import/no-unused-modules\n\n\nexport default {\n  name: 'preventOverflow',\n  enabled: true,\n  phase: 'main',\n  fn: preventOverflow,\n  requiresIfExists: ['offset']\n};","export default function getAltAxis(axis) {\n  return axis === 'x' ? 'y' : 'x';\n}","import getBoundingClientRect from \"./getBoundingClientRect.js\";\nimport getNodeScroll from \"./getNodeScroll.js\";\nimport getNodeName from \"./getNodeName.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getWindowScrollBarX from \"./getWindowScrollBarX.js\";\nimport getDocumentElement from \"./getDocumentElement.js\";\nimport isScrollParent from \"./isScrollParent.js\";\nimport { round } from \"../utils/math.js\";\n\nfunction isElementScaled(element) {\n  var rect = element.getBoundingClientRect();\n  var scaleX = round(rect.width) / element.offsetWidth || 1;\n  var scaleY = round(rect.height) / element.offsetHeight || 1;\n  return scaleX !== 1 || scaleY !== 1;\n} // Returns the composite rect of an element relative to its offsetParent.\n// Composite means it takes into account transforms as well as layout.\n\n\nexport default function getCompositeRect(elementOrVirtualElement, offsetParent, isFixed) {\n  if (isFixed === void 0) {\n    isFixed = false;\n  }\n\n  var isOffsetParentAnElement = isHTMLElement(offsetParent);\n  var offsetParentIsScaled = isHTMLElement(offsetParent) && isElementScaled(offsetParent);\n  var documentElement = getDocumentElement(offsetParent);\n  var rect = getBoundingClientRect(elementOrVirtualElement, offsetParentIsScaled, isFixed);\n  var scroll = {\n    scrollLeft: 0,\n    scrollTop: 0\n  };\n  var offsets = {\n    x: 0,\n    y: 0\n  };\n\n  if (isOffsetParentAnElement || !isOffsetParentAnElement && !isFixed) {\n    if (getNodeName(offsetParent) !== 'body' || // https://github.com/popperjs/popper-core/issues/1078\n    isScrollParent(documentElement)) {\n      scroll = getNodeScroll(offsetParent);\n    }\n\n    if (isHTMLElement(offsetParent)) {\n      offsets = getBoundingClientRect(offsetParent, true);\n      offsets.x += offsetParent.clientLeft;\n      offsets.y += offsetParent.clientTop;\n    } else if (documentElement) {\n      offsets.x = getWindowScrollBarX(documentElement);\n    }\n  }\n\n  return {\n    x: rect.left + scroll.scrollLeft - offsets.x,\n    y: rect.top + scroll.scrollTop - offsets.y,\n    width: rect.width,\n    height: rect.height\n  };\n}","import getWindowScroll from \"./getWindowScroll.js\";\nimport getWindow from \"./getWindow.js\";\nimport { isHTMLElement } from \"./instanceOf.js\";\nimport getHTMLElementScroll from \"./getHTMLElementScroll.js\";\nexport default function getNodeScroll(node) {\n  if (node === getWindow(node) || !isHTMLElement(node)) {\n    return getWindowScroll(node);\n  } else {\n    return getHTMLElementScroll(node);\n  }\n}","export default function getHTMLElementScroll(element) {\n  return {\n    scrollLeft: element.scrollLeft,\n    scrollTop: element.scrollTop\n  };\n}","import { modifierPhases } from \"../enums.js\"; // source: https://stackoverflow.com/questions/49875255\n\nfunction order(modifiers) {\n  var map = new Map();\n  var visited = new Set();\n  var result = [];\n  modifiers.forEach(function (modifier) {\n    map.set(modifier.name, modifier);\n  }); // On visiting object, check for its dependencies and visit them recursively\n\n  function sort(modifier) {\n    visited.add(modifier.name);\n    var requires = [].concat(modifier.requires || [], modifier.requiresIfExists || []);\n    requires.forEach(function (dep) {\n      if (!visited.has(dep)) {\n        var depModifier = map.get(dep);\n\n        if (depModifier) {\n          sort(depModifier);\n        }\n      }\n    });\n    result.push(modifier);\n  }\n\n  modifiers.forEach(function (modifier) {\n    if (!visited.has(modifier.name)) {\n      // check for visited object\n      sort(modifier);\n    }\n  });\n  return result;\n}\n\nexport default function orderModifiers(modifiers) {\n  // order based on dependencies\n  var orderedModifiers = order(modifiers); // order based on phase\n\n  return modifierPhases.reduce(function (acc, phase) {\n    return acc.concat(orderedModifiers.filter(function (modifier) {\n      return modifier.phase === phase;\n    }));\n  }, []);\n}","import getCompositeRect from \"./dom-utils/getCompositeRect.js\";\nimport getLayoutRect from \"./dom-utils/getLayoutRect.js\";\nimport listScrollParents from \"./dom-utils/listScrollParents.js\";\nimport getOffsetParent from \"./dom-utils/getOffsetParent.js\";\nimport orderModifiers from \"./utils/orderModifiers.js\";\nimport debounce from \"./utils/debounce.js\";\nimport mergeByName from \"./utils/mergeByName.js\";\nimport detectOverflow from \"./utils/detectOverflow.js\";\nimport { isElement } from \"./dom-utils/instanceOf.js\";\nvar DEFAULT_OPTIONS = {\n  placement: 'bottom',\n  modifiers: [],\n  strategy: 'absolute'\n};\n\nfunction areValidElements() {\n  for (var _len = arguments.length, args = new Array(_len), _key = 0; _key < _len; _key++) {\n    args[_key] = arguments[_key];\n  }\n\n  return !args.some(function (element) {\n    return !(element && typeof element.getBoundingClientRect === 'function');\n  });\n}\n\nexport function popperGenerator(generatorOptions) {\n  if (generatorOptions === void 0) {\n    generatorOptions = {};\n  }\n\n  var _generatorOptions = generatorOptions,\n      _generatorOptions$def = _generatorOptions.defaultModifiers,\n      defaultModifiers = _generatorOptions$def === void 0 ? [] : _generatorOptions$def,\n      _generatorOptions$def2 = _generatorOptions.defaultOptions,\n      defaultOptions = _generatorOptions$def2 === void 0 ? DEFAULT_OPTIONS : _generatorOptions$def2;\n  return function createPopper(reference, popper, options) {\n    if (options === void 0) {\n      options = defaultOptions;\n    }\n\n    var state = {\n      placement: 'bottom',\n      orderedModifiers: [],\n      options: Object.assign({}, DEFAULT_OPTIONS, defaultOptions),\n      modifiersData: {},\n      elements: {\n        reference: reference,\n        popper: popper\n      },\n      attributes: {},\n      styles: {}\n    };\n    var effectCleanupFns = [];\n    var isDestroyed = false;\n    var instance = {\n      state: state,\n      setOptions: function setOptions(setOptionsAction) {\n        var options = typeof setOptionsAction === 'function' ? setOptionsAction(state.options) : setOptionsAction;\n        cleanupModifierEffects();\n        state.options = Object.assign({}, defaultOptions, state.options, options);\n        state.scrollParents = {\n          reference: isElement(reference) ? listScrollParents(reference) : reference.contextElement ? listScrollParents(reference.contextElement) : [],\n          popper: listScrollParents(popper)\n        }; // Orders the modifiers based on their dependencies and `phase`\n        // properties\n\n        var orderedModifiers = orderModifiers(mergeByName([].concat(defaultModifiers, state.options.modifiers))); // Strip out disabled modifiers\n\n        state.orderedModifiers = orderedModifiers.filter(function (m) {\n          return m.enabled;\n        });\n        runModifierEffects();\n        return instance.update();\n      },\n      // Sync update – it will always be executed, even if not necessary. This\n      // is useful for low frequency updates where sync behavior simplifies the\n      // logic.\n      // For high frequency updates (e.g. `resize` and `scroll` events), always\n      // prefer the async Popper#update method\n      forceUpdate: function forceUpdate() {\n        if (isDestroyed) {\n          return;\n        }\n\n        var _state$elements = state.elements,\n            reference = _state$elements.reference,\n            popper = _state$elements.popper; // Don't proceed if `reference` or `popper` are not valid elements\n        // anymore\n\n        if (!areValidElements(reference, popper)) {\n          return;\n        } // Store the reference and popper rects to be read by modifiers\n\n\n        state.rects = {\n          reference: getCompositeRect(reference, getOffsetParent(popper), state.options.strategy === 'fixed'),\n          popper: getLayoutRect(popper)\n        }; // Modifiers have the ability to reset the current update cycle. The\n        // most common use case for this is the `flip` modifier changing the\n        // placement, which then needs to re-run all the modifiers, because the\n        // logic was previously ran for the previous placement and is therefore\n        // stale/incorrect\n\n        state.reset = false;\n        state.placement = state.options.placement; // On each update cycle, the `modifiersData` property for each modifier\n        // is filled with the initial data specified by the modifier. This means\n        // it doesn't persist and is fresh on each update.\n        // To ensure persistent data, use `${name}#persistent`\n\n        state.orderedModifiers.forEach(function (modifier) {\n          return state.modifiersData[modifier.name] = Object.assign({}, modifier.data);\n        });\n\n        for (var index = 0; index < state.orderedModifiers.length; index++) {\n          if (state.reset === true) {\n            state.reset = false;\n            index = -1;\n            continue;\n          }\n\n          var _state$orderedModifie = state.orderedModifiers[index],\n              fn = _state$orderedModifie.fn,\n              _state$orderedModifie2 = _state$orderedModifie.options,\n              _options = _state$orderedModifie2 === void 0 ? {} : _state$orderedModifie2,\n              name = _state$orderedModifie.name;\n\n          if (typeof fn === 'function') {\n            state = fn({\n              state: state,\n              options: _options,\n              name: name,\n              instance: instance\n            }) || state;\n          }\n        }\n      },\n      // Async and optimistically optimized update – it will not be executed if\n      // not necessary (debounced to run at most once-per-tick)\n      update: debounce(function () {\n        return new Promise(function (resolve) {\n          instance.forceUpdate();\n          resolve(state);\n        });\n      }),\n      destroy: function destroy() {\n        cleanupModifierEffects();\n        isDestroyed = true;\n      }\n    };\n\n    if (!areValidElements(reference, popper)) {\n      return instance;\n    }\n\n    instance.setOptions(options).then(function (state) {\n      if (!isDestroyed && options.onFirstUpdate) {\n        options.onFirstUpdate(state);\n      }\n    }); // Modifiers have the ability to execute arbitrary code before the first\n    // update cycle runs. They will be executed in the same order as the update\n    // cycle. This is useful when a modifier adds some persistent data that\n    // other modifiers need to use, but the modifier is run after the dependent\n    // one.\n\n    function runModifierEffects() {\n      state.orderedModifiers.forEach(function (_ref) {\n        var name = _ref.name,\n            _ref$options = _ref.options,\n            options = _ref$options === void 0 ? {} : _ref$options,\n            effect = _ref.effect;\n\n        if (typeof effect === 'function') {\n          var cleanupFn = effect({\n            state: state,\n            name: name,\n            instance: instance,\n            options: options\n          });\n\n          var noopFn = function noopFn() {};\n\n          effectCleanupFns.push(cleanupFn || noopFn);\n        }\n      });\n    }\n\n    function cleanupModifierEffects() {\n      effectCleanupFns.forEach(function (fn) {\n        return fn();\n      });\n      effectCleanupFns = [];\n    }\n\n    return instance;\n  };\n}\nexport var createPopper = /*#__PURE__*/popperGenerator(); // eslint-disable-next-line import/no-unused-modules\n\nexport { detectOverflow };","export default function debounce(fn) {\n  var pending;\n  return function () {\n    if (!pending) {\n      pending = new Promise(function (resolve) {\n        Promise.resolve().then(function () {\n          pending = undefined;\n          resolve(fn());\n        });\n      });\n    }\n\n    return pending;\n  };\n}","export default function mergeByName(modifiers) {\n  var merged = modifiers.reduce(function (merged, current) {\n    var existing = merged[current.name];\n    merged[current.name] = existing ? Object.assign({}, existing, current, {\n      options: Object.assign({}, existing.options, current.options),\n      data: Object.assign({}, existing.data, current.data)\n    }) : current;\n    return merged;\n  }, {}); // IE11 does not support Object.values\n\n  return Object.keys(merged).map(function (key) {\n    return merged[key];\n  });\n}","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles];\nvar createPopper = /*#__PURE__*/popperGenerator({\n  defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow };","import { popperGenerator, detectOverflow } from \"./createPopper.js\";\nimport eventListeners from \"./modifiers/eventListeners.js\";\nimport popperOffsets from \"./modifiers/popperOffsets.js\";\nimport computeStyles from \"./modifiers/computeStyles.js\";\nimport applyStyles from \"./modifiers/applyStyles.js\";\nimport offset from \"./modifiers/offset.js\";\nimport flip from \"./modifiers/flip.js\";\nimport preventOverflow from \"./modifiers/preventOverflow.js\";\nimport arrow from \"./modifiers/arrow.js\";\nimport hide from \"./modifiers/hide.js\";\nvar defaultModifiers = [eventListeners, popperOffsets, computeStyles, applyStyles, offset, flip, preventOverflow, arrow, hide];\nvar createPopper = /*#__PURE__*/popperGenerator({\n  defaultModifiers: defaultModifiers\n}); // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper, popperGenerator, defaultModifiers, detectOverflow }; // eslint-disable-next-line import/no-unused-modules\n\nexport { createPopper as createPopperLite } from \"./popper-lite.js\"; // eslint-disable-next-line import/no-unused-modules\n\nexport * from \"./modifiers/index.js\";","/**\n * --------------------------------------------------------------------------\n * Bootstrap dropdown.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport Manipulator from './dom/manipulator.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport {\n  defineJQueryPlugin,\n  execute,\n  getElement,\n  getNextActiveElement,\n  isDisabled,\n  isElement,\n  isRTL,\n  isVisible,\n  noop\n} from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'dropdown'\nconst DATA_KEY = 'bs.dropdown'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst ESCAPE_KEY = 'Escape'\nconst TAB_KEY = 'Tab'\nconst ARROW_UP_KEY = 'ArrowUp'\nconst ARROW_DOWN_KEY = 'ArrowDown'\nconst RIGHT_MOUSE_BUTTON = 2 // MouseEvent.button value for the secondary button, usually the right button\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DATA_API = `keydown${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYUP_DATA_API = `keyup${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_DROPUP = 'dropup'\nconst CLASS_NAME_DROPEND = 'dropend'\nconst CLASS_NAME_DROPSTART = 'dropstart'\nconst CLASS_NAME_DROPUP_CENTER = 'dropup-center'\nconst CLASS_NAME_DROPDOWN_CENTER = 'dropdown-center'\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"dropdown\"]:not(.disabled):not(:disabled)'\nconst SELECTOR_DATA_TOGGLE_SHOWN = `${SELECTOR_DATA_TOGGLE}.${CLASS_NAME_SHOW}`\nconst SELECTOR_MENU = '.dropdown-menu'\nconst SELECTOR_NAVBAR = '.navbar'\nconst SELECTOR_NAVBAR_NAV = '.navbar-nav'\nconst SELECTOR_VISIBLE_ITEMS = '.dropdown-menu .dropdown-item:not(.disabled):not(:disabled)'\n\nconst PLACEMENT_TOP = isRTL() ? 'top-end' : 'top-start'\nconst PLACEMENT_TOPEND = isRTL() ? 'top-start' : 'top-end'\nconst PLACEMENT_BOTTOM = isRTL() ? 'bottom-end' : 'bottom-start'\nconst PLACEMENT_BOTTOMEND = isRTL() ? 'bottom-start' : 'bottom-end'\nconst PLACEMENT_RIGHT = isRTL() ? 'left-start' : 'right-start'\nconst PLACEMENT_LEFT = isRTL() ? 'right-start' : 'left-start'\nconst PLACEMENT_TOPCENTER = 'top'\nconst PLACEMENT_BOTTOMCENTER = 'bottom'\n\nconst Default = {\n  autoClose: true,\n  boundary: 'clippingParents',\n  display: 'dynamic',\n  offset: [0, 2],\n  popperConfig: null,\n  reference: 'toggle'\n}\n\nconst DefaultType = {\n  autoClose: '(boolean|string)',\n  boundary: '(string|element)',\n  display: 'string',\n  offset: '(array|string|function)',\n  popperConfig: '(null|object|function)',\n  reference: '(string|element|object)'\n}\n\n/**\n * Class definition\n */\n\nclass Dropdown extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._popper = null\n    this._parent = this._element.parentNode // dropdown wrapper\n    // TODO: v6 revert #37011 & change markup https://getbootstrap.com/docs/5.3/forms/input-group/\n    this._menu = SelectorEngine.next(this._element, SELECTOR_MENU)[0] ||\n      SelectorEngine.prev(this._element, SELECTOR_MENU)[0] ||\n      SelectorEngine.findOne(SELECTOR_MENU, this._parent)\n    this._inNavbar = this._detectNavbar()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle() {\n    return this._isShown() ? this.hide() : this.show()\n  }\n\n  show() {\n    if (isDisabled(this._element) || this._isShown()) {\n      return\n    }\n\n    const relatedTarget = {\n      relatedTarget: this._element\n    }\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, relatedTarget)\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._createPopper()\n\n    // If this is a touch-enabled device we add extra\n    // empty mouseover listeners to the body's immediate children;\n    // only needed because of broken event delegation on iOS\n    // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n    if ('ontouchstart' in document.documentElement && !this._parent.closest(SELECTOR_NAVBAR_NAV)) {\n      for (const element of [].concat(...document.body.children)) {\n        EventHandler.on(element, 'mouseover', noop)\n      }\n    }\n\n    this._element.focus()\n    this._element.setAttribute('aria-expanded', true)\n\n    this._menu.classList.add(CLASS_NAME_SHOW)\n    this._element.classList.add(CLASS_NAME_SHOW)\n    EventHandler.trigger(this._element, EVENT_SHOWN, relatedTarget)\n  }\n\n  hide() {\n    if (isDisabled(this._element) || !this._isShown()) {\n      return\n    }\n\n    const relatedTarget = {\n      relatedTarget: this._element\n    }\n\n    this._completeHide(relatedTarget)\n  }\n\n  dispose() {\n    if (this._popper) {\n      this._popper.destroy()\n    }\n\n    super.dispose()\n  }\n\n  update() {\n    this._inNavbar = this._detectNavbar()\n    if (this._popper) {\n      this._popper.update()\n    }\n  }\n\n  // Private\n  _completeHide(relatedTarget) {\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE, relatedTarget)\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    // If this is a touch-enabled device we remove the extra\n    // empty mouseover listeners we added for iOS support\n    if ('ontouchstart' in document.documentElement) {\n      for (const element of [].concat(...document.body.children)) {\n        EventHandler.off(element, 'mouseover', noop)\n      }\n    }\n\n    if (this._popper) {\n      this._popper.destroy()\n    }\n\n    this._menu.classList.remove(CLASS_NAME_SHOW)\n    this._element.classList.remove(CLASS_NAME_SHOW)\n    this._element.setAttribute('aria-expanded', 'false')\n    Manipulator.removeDataAttribute(this._menu, 'popper')\n    EventHandler.trigger(this._element, EVENT_HIDDEN, relatedTarget)\n  }\n\n  _getConfig(config) {\n    config = super._getConfig(config)\n\n    if (typeof config.reference === 'object' && !isElement(config.reference) &&\n      typeof config.reference.getBoundingClientRect !== 'function'\n    ) {\n      // Popper virtual elements require a getBoundingClientRect method\n      throw new TypeError(`${NAME.toUpperCase()}: Option \"reference\" provided type \"object\" without a required \"getBoundingClientRect\" method.`)\n    }\n\n    return config\n  }\n\n  _createPopper() {\n    if (typeof Popper === 'undefined') {\n      throw new TypeError('Bootstrap\\'s dropdowns require Popper (https://popper.js.org)')\n    }\n\n    let referenceElement = this._element\n\n    if (this._config.reference === 'parent') {\n      referenceElement = this._parent\n    } else if (isElement(this._config.reference)) {\n      referenceElement = getElement(this._config.reference)\n    } else if (typeof this._config.reference === 'object') {\n      referenceElement = this._config.reference\n    }\n\n    const popperConfig = this._getPopperConfig()\n    this._popper = Popper.createPopper(referenceElement, this._menu, popperConfig)\n  }\n\n  _isShown() {\n    return this._menu.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  _getPlacement() {\n    const parentDropdown = this._parent\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPEND)) {\n      return PLACEMENT_RIGHT\n    }\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPSTART)) {\n      return PLACEMENT_LEFT\n    }\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPUP_CENTER)) {\n      return PLACEMENT_TOPCENTER\n    }\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPDOWN_CENTER)) {\n      return PLACEMENT_BOTTOMCENTER\n    }\n\n    // We need to trim the value because custom properties can also include spaces\n    const isEnd = getComputedStyle(this._menu).getPropertyValue('--bs-position').trim() === 'end'\n\n    if (parentDropdown.classList.contains(CLASS_NAME_DROPUP)) {\n      return isEnd ? PLACEMENT_TOPEND : PLACEMENT_TOP\n    }\n\n    return isEnd ? PLACEMENT_BOTTOMEND : PLACEMENT_BOTTOM\n  }\n\n  _detectNavbar() {\n    return this._element.closest(SELECTOR_NAVBAR) !== null\n  }\n\n  _getOffset() {\n    const { offset } = this._config\n\n    if (typeof offset === 'string') {\n      return offset.split(',').map(value => Number.parseInt(value, 10))\n    }\n\n    if (typeof offset === 'function') {\n      return popperData => offset(popperData, this._element)\n    }\n\n    return offset\n  }\n\n  _getPopperConfig() {\n    const defaultBsPopperConfig = {\n      placement: this._getPlacement(),\n      modifiers: [{\n        name: 'preventOverflow',\n        options: {\n          boundary: this._config.boundary\n        }\n      },\n      {\n        name: 'offset',\n        options: {\n          offset: this._getOffset()\n        }\n      }]\n    }\n\n    // Disable Popper if we have a static display or Dropdown is in Navbar\n    if (this._inNavbar || this._config.display === 'static') {\n      Manipulator.setDataAttribute(this._menu, 'popper', 'static') // TODO: v6 remove\n      defaultBsPopperConfig.modifiers = [{\n        name: 'applyStyles',\n        enabled: false\n      }]\n    }\n\n    return {\n      ...defaultBsPopperConfig,\n      ...execute(this._config.popperConfig, [defaultBsPopperConfig])\n    }\n  }\n\n  _selectMenuItem({ key, target }) {\n    const items = SelectorEngine.find(SELECTOR_VISIBLE_ITEMS, this._menu).filter(element => isVisible(element))\n\n    if (!items.length) {\n      return\n    }\n\n    // if target isn't included in items (e.g. when expanding the dropdown)\n    // allow cycling to get the last item in case key equals ARROW_UP_KEY\n    getNextActiveElement(items, target, key === ARROW_DOWN_KEY, !items.includes(target)).focus()\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Dropdown.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n\n  static clearMenus(event) {\n    if (event.button === RIGHT_MOUSE_BUTTON || (event.type === 'keyup' && event.key !== TAB_KEY)) {\n      return\n    }\n\n    const openToggles = SelectorEngine.find(SELECTOR_DATA_TOGGLE_SHOWN)\n\n    for (const toggle of openToggles) {\n      const context = Dropdown.getInstance(toggle)\n      if (!context || context._config.autoClose === false) {\n        continue\n      }\n\n      const composedPath = event.composedPath()\n      const isMenuTarget = composedPath.includes(context._menu)\n      if (\n        composedPath.includes(context._element) ||\n        (context._config.autoClose === 'inside' && !isMenuTarget) ||\n        (context._config.autoClose === 'outside' && isMenuTarget)\n      ) {\n        continue\n      }\n\n      // Tab navigation through the dropdown menu or events from contained inputs shouldn't close the menu\n      if (context._menu.contains(event.target) && ((event.type === 'keyup' && event.key === TAB_KEY) || /input|select|option|textarea|form/i.test(event.target.tagName))) {\n        continue\n      }\n\n      const relatedTarget = { relatedTarget: context._element }\n\n      if (event.type === 'click') {\n        relatedTarget.clickEvent = event\n      }\n\n      context._completeHide(relatedTarget)\n    }\n  }\n\n  static dataApiKeydownHandler(event) {\n    // If not an UP | DOWN | ESCAPE key => not a dropdown command\n    // If input/textarea && if key is other than ESCAPE => not a dropdown command\n\n    const isInput = /input|textarea/i.test(event.target.tagName)\n    const isEscapeEvent = event.key === ESCAPE_KEY\n    const isUpOrDownEvent = [ARROW_UP_KEY, ARROW_DOWN_KEY].includes(event.key)\n\n    if (!isUpOrDownEvent && !isEscapeEvent) {\n      return\n    }\n\n    if (isInput && !isEscapeEvent) {\n      return\n    }\n\n    event.preventDefault()\n\n    // TODO: v6 revert #37011 & change markup https://getbootstrap.com/docs/5.3/forms/input-group/\n    const getToggleButton = this.matches(SELECTOR_DATA_TOGGLE) ?\n      this :\n      (SelectorEngine.prev(this, SELECTOR_DATA_TOGGLE)[0] ||\n        SelectorEngine.next(this, SELECTOR_DATA_TOGGLE)[0] ||\n        SelectorEngine.findOne(SELECTOR_DATA_TOGGLE, event.delegateTarget.parentNode))\n\n    const instance = Dropdown.getOrCreateInstance(getToggleButton)\n\n    if (isUpOrDownEvent) {\n      event.stopPropagation()\n      instance.show()\n      instance._selectMenuItem(event)\n      return\n    }\n\n    if (instance._isShown()) { // else is escape and we check if it is shown\n      event.stopPropagation()\n      instance.hide()\n      getToggleButton.focus()\n    }\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_DATA_TOGGLE, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_KEYDOWN_DATA_API, SELECTOR_MENU, Dropdown.dataApiKeydownHandler)\nEventHandler.on(document, EVENT_CLICK_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_KEYUP_DATA_API, Dropdown.clearMenus)\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  event.preventDefault()\n  Dropdown.getOrCreateInstance(this).toggle()\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Dropdown)\n\nexport default Dropdown\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/backdrop.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport Config from './config.js'\nimport { execute, executeAfterTransition, getElement, reflow } from './index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'backdrop'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst EVENT_MOUSEDOWN = `mousedown.bs.${NAME}`\n\nconst Default = {\n  className: 'modal-backdrop',\n  clickCallback: null,\n  isAnimated: false,\n  isVisible: true, // if false, we use the backdrop helper without adding any element to the dom\n  rootElement: 'body' // give the choice to place backdrop under different elements\n}\n\nconst DefaultType = {\n  className: 'string',\n  clickCallback: '(function|null)',\n  isAnimated: 'boolean',\n  isVisible: 'boolean',\n  rootElement: '(element|string)'\n}\n\n/**\n * Class definition\n */\n\nclass Backdrop extends Config {\n  constructor(config) {\n    super()\n    this._config = this._getConfig(config)\n    this._isAppended = false\n    this._element = null\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  show(callback) {\n    if (!this._config.isVisible) {\n      execute(callback)\n      return\n    }\n\n    this._append()\n\n    const element = this._getElement()\n    if (this._config.isAnimated) {\n      reflow(element)\n    }\n\n    element.classList.add(CLASS_NAME_SHOW)\n\n    this._emulateAnimation(() => {\n      execute(callback)\n    })\n  }\n\n  hide(callback) {\n    if (!this._config.isVisible) {\n      execute(callback)\n      return\n    }\n\n    this._getElement().classList.remove(CLASS_NAME_SHOW)\n\n    this._emulateAnimation(() => {\n      this.dispose()\n      execute(callback)\n    })\n  }\n\n  dispose() {\n    if (!this._isAppended) {\n      return\n    }\n\n    EventHandler.off(this._element, EVENT_MOUSEDOWN)\n\n    this._element.remove()\n    this._isAppended = false\n  }\n\n  // Private\n  _getElement() {\n    if (!this._element) {\n      const backdrop = document.createElement('div')\n      backdrop.className = this._config.className\n      if (this._config.isAnimated) {\n        backdrop.classList.add(CLASS_NAME_FADE)\n      }\n\n      this._element = backdrop\n    }\n\n    return this._element\n  }\n\n  _configAfterMerge(config) {\n    // use getElement() with the default \"body\" to get a fresh Element on each instantiation\n    config.rootElement = getElement(config.rootElement)\n    return config\n  }\n\n  _append() {\n    if (this._isAppended) {\n      return\n    }\n\n    const element = this._getElement()\n    this._config.rootElement.append(element)\n\n    EventHandler.on(element, EVENT_MOUSEDOWN, () => {\n      execute(this._config.clickCallback)\n    })\n\n    this._isAppended = true\n  }\n\n  _emulateAnimation(callback) {\n    executeAfterTransition(callback, this._getElement(), this._config.isAnimated)\n  }\n}\n\nexport default Backdrop\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/focustrap.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport EventHandler from '../dom/event-handler.js'\nimport SelectorEngine from '../dom/selector-engine.js'\nimport Config from './config.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'focustrap'\nconst DATA_KEY = 'bs.focustrap'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst EVENT_FOCUSIN = `focusin${EVENT_KEY}`\nconst EVENT_KEYDOWN_TAB = `keydown.tab${EVENT_KEY}`\n\nconst TAB_KEY = 'Tab'\nconst TAB_NAV_FORWARD = 'forward'\nconst TAB_NAV_BACKWARD = 'backward'\n\nconst Default = {\n  autofocus: true,\n  trapElement: null // The element to trap focus inside of\n}\n\nconst DefaultType = {\n  autofocus: 'boolean',\n  trapElement: 'element'\n}\n\n/**\n * Class definition\n */\n\nclass FocusTrap extends Config {\n  constructor(config) {\n    super()\n    this._config = this._getConfig(config)\n    this._isActive = false\n    this._lastTabNavDirection = null\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  activate() {\n    if (this._isActive) {\n      return\n    }\n\n    if (this._config.autofocus) {\n      this._config.trapElement.focus()\n    }\n\n    EventHandler.off(document, EVENT_KEY) // guard against infinite focus loop\n    EventHandler.on(document, EVENT_FOCUSIN, event => this._handleFocusin(event))\n    EventHandler.on(document, EVENT_KEYDOWN_TAB, event => this._handleKeydown(event))\n\n    this._isActive = true\n  }\n\n  deactivate() {\n    if (!this._isActive) {\n      return\n    }\n\n    this._isActive = false\n    EventHandler.off(document, EVENT_KEY)\n  }\n\n  // Private\n  _handleFocusin(event) {\n    const { trapElement } = this._config\n\n    if (event.target === document || event.target === trapElement || trapElement.contains(event.target)) {\n      return\n    }\n\n    const elements = SelectorEngine.focusableChildren(trapElement)\n\n    if (elements.length === 0) {\n      trapElement.focus()\n    } else if (this._lastTabNavDirection === TAB_NAV_BACKWARD) {\n      elements[elements.length - 1].focus()\n    } else {\n      elements[0].focus()\n    }\n  }\n\n  _handleKeydown(event) {\n    if (event.key !== TAB_KEY) {\n      return\n    }\n\n    this._lastTabNavDirection = event.shiftKey ? TAB_NAV_BACKWARD : TAB_NAV_FORWARD\n  }\n}\n\nexport default FocusTrap\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/scrollBar.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Manipulator from '../dom/manipulator.js'\nimport SelectorEngine from '../dom/selector-engine.js'\nimport { isElement } from './index.js'\n\n/**\n * Constants\n */\n\nconst SELECTOR_FIXED_CONTENT = '.fixed-top, .fixed-bottom, .is-fixed, .sticky-top'\nconst SELECTOR_STICKY_CONTENT = '.sticky-top'\nconst PROPERTY_PADDING = 'padding-right'\nconst PROPERTY_MARGIN = 'margin-right'\n\n/**\n * Class definition\n */\n\nclass ScrollBarHelper {\n  constructor() {\n    this._element = document.body\n  }\n\n  // Public\n  getWidth() {\n    // https://developer.mozilla.org/en-US/docs/Web/API/Window/innerWidth#usage_notes\n    const documentWidth = document.documentElement.clientWidth\n    return Math.abs(window.innerWidth - documentWidth)\n  }\n\n  hide() {\n    const width = this.getWidth()\n    this._disableOverFlow()\n    // give padding to element to balance the hidden scrollbar width\n    this._setElementAttributes(this._element, PROPERTY_PADDING, calculatedValue => calculatedValue + width)\n    // trick: We adjust positive paddingRight and negative marginRight to sticky-top elements to keep showing fullwidth\n    this._setElementAttributes(SELECTOR_FIXED_CONTENT, PROPERTY_PADDING, calculatedValue => calculatedValue + width)\n    this._setElementAttributes(SELECTOR_STICKY_CONTENT, PROPERTY_MARGIN, calculatedValue => calculatedValue - width)\n  }\n\n  reset() {\n    this._resetElementAttributes(this._element, 'overflow')\n    this._resetElementAttributes(this._element, PROPERTY_PADDING)\n    this._resetElementAttributes(SELECTOR_FIXED_CONTENT, PROPERTY_PADDING)\n    this._resetElementAttributes(SELECTOR_STICKY_CONTENT, PROPERTY_MARGIN)\n  }\n\n  isOverflowing() {\n    return this.getWidth() > 0\n  }\n\n  // Private\n  _disableOverFlow() {\n    this._saveInitialAttribute(this._element, 'overflow')\n    this._element.style.overflow = 'hidden'\n  }\n\n  _setElementAttributes(selector, styleProperty, callback) {\n    const scrollbarWidth = this.getWidth()\n    const manipulationCallBack = element => {\n      if (element !== this._element && window.innerWidth > element.clientWidth + scrollbarWidth) {\n        return\n      }\n\n      this._saveInitialAttribute(element, styleProperty)\n      const calculatedValue = window.getComputedStyle(element).getPropertyValue(styleProperty)\n      element.style.setProperty(styleProperty, `${callback(Number.parseFloat(calculatedValue))}px`)\n    }\n\n    this._applyManipulationCallback(selector, manipulationCallBack)\n  }\n\n  _saveInitialAttribute(element, styleProperty) {\n    const actualValue = element.style.getPropertyValue(styleProperty)\n    if (actualValue) {\n      Manipulator.setDataAttribute(element, styleProperty, actualValue)\n    }\n  }\n\n  _resetElementAttributes(selector, styleProperty) {\n    const manipulationCallBack = element => {\n      const value = Manipulator.getDataAttribute(element, styleProperty)\n      // We only want to remove the property if the value is `null`; the value can also be zero\n      if (value === null) {\n        element.style.removeProperty(styleProperty)\n        return\n      }\n\n      Manipulator.removeDataAttribute(element, styleProperty)\n      element.style.setProperty(styleProperty, value)\n    }\n\n    this._applyManipulationCallback(selector, manipulationCallBack)\n  }\n\n  _applyManipulationCallback(selector, callBack) {\n    if (isElement(selector)) {\n      callBack(selector)\n      return\n    }\n\n    for (const sel of SelectorEngine.find(selector, this._element)) {\n      callBack(sel)\n    }\n  }\n}\n\nexport default ScrollBarHelper\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap modal.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport Backdrop from './util/backdrop.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport FocusTrap from './util/focustrap.js'\nimport { defineJQueryPlugin, isRTL, isVisible, reflow } from './util/index.js'\nimport ScrollBarHelper from './util/scrollbar.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'modal'\nconst DATA_KEY = 'bs.modal'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst ESCAPE_KEY = 'Escape'\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DISMISS = `click.dismiss${EVENT_KEY}`\nconst EVENT_MOUSEDOWN_DISMISS = `mousedown.dismiss${EVENT_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_OPEN = 'modal-open'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_STATIC = 'modal-static'\n\nconst OPEN_SELECTOR = '.modal.show'\nconst SELECTOR_DIALOG = '.modal-dialog'\nconst SELECTOR_MODAL_BODY = '.modal-body'\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"modal\"]'\n\nconst Default = {\n  backdrop: true,\n  focus: true,\n  keyboard: true\n}\n\nconst DefaultType = {\n  backdrop: '(boolean|string)',\n  focus: 'boolean',\n  keyboard: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Modal extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._dialog = SelectorEngine.findOne(SELECTOR_DIALOG, this._element)\n    this._backdrop = this._initializeBackDrop()\n    this._focustrap = this._initializeFocusTrap()\n    this._isShown = false\n    this._isTransitioning = false\n    this._scrollBar = new ScrollBarHelper()\n\n    this._addEventListeners()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle(relatedTarget) {\n    return this._isShown ? this.hide() : this.show(relatedTarget)\n  }\n\n  show(relatedTarget) {\n    if (this._isShown || this._isTransitioning) {\n      return\n    }\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, {\n      relatedTarget\n    })\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._isShown = true\n    this._isTransitioning = true\n\n    this._scrollBar.hide()\n\n    document.body.classList.add(CLASS_NAME_OPEN)\n\n    this._adjustDialog()\n\n    this._backdrop.show(() => this._showElement(relatedTarget))\n  }\n\n  hide() {\n    if (!this._isShown || this._isTransitioning) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    this._isShown = false\n    this._isTransitioning = true\n    this._focustrap.deactivate()\n\n    this._element.classList.remove(CLASS_NAME_SHOW)\n\n    this._queueCallback(() => this._hideModal(), this._element, this._isAnimated())\n  }\n\n  dispose() {\n    EventHandler.off(window, EVENT_KEY)\n    EventHandler.off(this._dialog, EVENT_KEY)\n\n    this._backdrop.dispose()\n    this._focustrap.deactivate()\n\n    super.dispose()\n  }\n\n  handleUpdate() {\n    this._adjustDialog()\n  }\n\n  // Private\n  _initializeBackDrop() {\n    return new Backdrop({\n      isVisible: Boolean(this._config.backdrop), // 'static' option will be translated to true, and booleans will keep their value,\n      isAnimated: this._isAnimated()\n    })\n  }\n\n  _initializeFocusTrap() {\n    return new FocusTrap({\n      trapElement: this._element\n    })\n  }\n\n  _showElement(relatedTarget) {\n    // try to append dynamic modal\n    if (!document.body.contains(this._element)) {\n      document.body.append(this._element)\n    }\n\n    this._element.style.display = 'block'\n    this._element.removeAttribute('aria-hidden')\n    this._element.setAttribute('aria-modal', true)\n    this._element.setAttribute('role', 'dialog')\n    this._element.scrollTop = 0\n\n    const modalBody = SelectorEngine.findOne(SELECTOR_MODAL_BODY, this._dialog)\n    if (modalBody) {\n      modalBody.scrollTop = 0\n    }\n\n    reflow(this._element)\n\n    this._element.classList.add(CLASS_NAME_SHOW)\n\n    const transitionComplete = () => {\n      if (this._config.focus) {\n        this._focustrap.activate()\n      }\n\n      this._isTransitioning = false\n      EventHandler.trigger(this._element, EVENT_SHOWN, {\n        relatedTarget\n      })\n    }\n\n    this._queueCallback(transitionComplete, this._dialog, this._isAnimated())\n  }\n\n  _addEventListeners() {\n    EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n      if (event.key !== ESCAPE_KEY) {\n        return\n      }\n\n      if (this._config.keyboard) {\n        this.hide()\n        return\n      }\n\n      this._triggerBackdropTransition()\n    })\n\n    EventHandler.on(window, EVENT_RESIZE, () => {\n      if (this._isShown && !this._isTransitioning) {\n        this._adjustDialog()\n      }\n    })\n\n    EventHandler.on(this._element, EVENT_MOUSEDOWN_DISMISS, event => {\n      // a bad trick to segregate clicks that may start inside dialog but end outside, and avoid listen to scrollbar clicks\n      EventHandler.one(this._element, EVENT_CLICK_DISMISS, event2 => {\n        if (this._element !== event.target || this._element !== event2.target) {\n          return\n        }\n\n        if (this._config.backdrop === 'static') {\n          this._triggerBackdropTransition()\n          return\n        }\n\n        if (this._config.backdrop) {\n          this.hide()\n        }\n      })\n    })\n  }\n\n  _hideModal() {\n    this._element.style.display = 'none'\n    this._element.setAttribute('aria-hidden', true)\n    this._element.removeAttribute('aria-modal')\n    this._element.removeAttribute('role')\n    this._isTransitioning = false\n\n    this._backdrop.hide(() => {\n      document.body.classList.remove(CLASS_NAME_OPEN)\n      this._resetAdjustments()\n      this._scrollBar.reset()\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    })\n  }\n\n  _isAnimated() {\n    return this._element.classList.contains(CLASS_NAME_FADE)\n  }\n\n  _triggerBackdropTransition() {\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n    const initialOverflowY = this._element.style.overflowY\n    // return if the following background transition hasn't yet completed\n    if (initialOverflowY === 'hidden' || this._element.classList.contains(CLASS_NAME_STATIC)) {\n      return\n    }\n\n    if (!isModalOverflowing) {\n      this._element.style.overflowY = 'hidden'\n    }\n\n    this._element.classList.add(CLASS_NAME_STATIC)\n    this._queueCallback(() => {\n      this._element.classList.remove(CLASS_NAME_STATIC)\n      this._queueCallback(() => {\n        this._element.style.overflowY = initialOverflowY\n      }, this._dialog)\n    }, this._dialog)\n\n    this._element.focus()\n  }\n\n  /**\n   * The following methods are used to handle overflowing modals\n   */\n\n  _adjustDialog() {\n    const isModalOverflowing = this._element.scrollHeight > document.documentElement.clientHeight\n    const scrollbarWidth = this._scrollBar.getWidth()\n    const isBodyOverflowing = scrollbarWidth > 0\n\n    if (isBodyOverflowing && !isModalOverflowing) {\n      const property = isRTL() ? 'paddingLeft' : 'paddingRight'\n      this._element.style[property] = `${scrollbarWidth}px`\n    }\n\n    if (!isBodyOverflowing && isModalOverflowing) {\n      const property = isRTL() ? 'paddingRight' : 'paddingLeft'\n      this._element.style[property] = `${scrollbarWidth}px`\n    }\n  }\n\n  _resetAdjustments() {\n    this._element.style.paddingLeft = ''\n    this._element.style.paddingRight = ''\n  }\n\n  // Static\n  static jQueryInterface(config, relatedTarget) {\n    return this.each(function () {\n      const data = Modal.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config](relatedTarget)\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  const target = SelectorEngine.getElementFromSelector(this)\n\n  if (['A', 'AREA'].includes(this.tagName)) {\n    event.preventDefault()\n  }\n\n  EventHandler.one(target, EVENT_SHOW, showEvent => {\n    if (showEvent.defaultPrevented) {\n      // only register focus restorer if modal will actually get shown\n      return\n    }\n\n    EventHandler.one(target, EVENT_HIDDEN, () => {\n      if (isVisible(this)) {\n        this.focus()\n      }\n    })\n  })\n\n  // avoid conflict when clicking modal toggler while another one is open\n  const alreadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n  if (alreadyOpen) {\n    Modal.getInstance(alreadyOpen).hide()\n  }\n\n  const data = Modal.getOrCreateInstance(target)\n\n  data.toggle(this)\n})\n\nenableDismissTrigger(Modal)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Modal)\n\nexport default Modal\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap offcanvas.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport Backdrop from './util/backdrop.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport FocusTrap from './util/focustrap.js'\nimport {\n  defineJQueryPlugin,\n  isDisabled,\n  isVisible\n} from './util/index.js'\nimport ScrollBarHelper from './util/scrollbar.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'offcanvas'\nconst DATA_KEY = 'bs.offcanvas'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\nconst ESCAPE_KEY = 'Escape'\n\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_SHOWING = 'showing'\nconst CLASS_NAME_HIDING = 'hiding'\nconst CLASS_NAME_BACKDROP = 'offcanvas-backdrop'\nconst OPEN_SELECTOR = '.offcanvas.show'\n\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDE_PREVENTED = `hidePrevented${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_RESIZE = `resize${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}${DATA_API_KEY}`\nconst EVENT_KEYDOWN_DISMISS = `keydown.dismiss${EVENT_KEY}`\n\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"offcanvas\"]'\n\nconst Default = {\n  backdrop: true,\n  keyboard: true,\n  scroll: false\n}\n\nconst DefaultType = {\n  backdrop: '(boolean|string)',\n  keyboard: 'boolean',\n  scroll: 'boolean'\n}\n\n/**\n * Class definition\n */\n\nclass Offcanvas extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._isShown = false\n    this._backdrop = this._initializeBackDrop()\n    this._focustrap = this._initializeFocusTrap()\n    this._addEventListeners()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  toggle(relatedTarget) {\n    return this._isShown ? this.hide() : this.show(relatedTarget)\n  }\n\n  show(relatedTarget) {\n    if (this._isShown) {\n      return\n    }\n\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW, { relatedTarget })\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._isShown = true\n    this._backdrop.show()\n\n    if (!this._config.scroll) {\n      new ScrollBarHelper().hide()\n    }\n\n    this._element.setAttribute('aria-modal', true)\n    this._element.setAttribute('role', 'dialog')\n    this._element.classList.add(CLASS_NAME_SHOWING)\n\n    const completeCallBack = () => {\n      if (!this._config.scroll || this._config.backdrop) {\n        this._focustrap.activate()\n      }\n\n      this._element.classList.add(CLASS_NAME_SHOW)\n      this._element.classList.remove(CLASS_NAME_SHOWING)\n      EventHandler.trigger(this._element, EVENT_SHOWN, { relatedTarget })\n    }\n\n    this._queueCallback(completeCallBack, this._element, true)\n  }\n\n  hide() {\n    if (!this._isShown) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    this._focustrap.deactivate()\n    this._element.blur()\n    this._isShown = false\n    this._element.classList.add(CLASS_NAME_HIDING)\n    this._backdrop.hide()\n\n    const completeCallback = () => {\n      this._element.classList.remove(CLASS_NAME_SHOW, CLASS_NAME_HIDING)\n      this._element.removeAttribute('aria-modal')\n      this._element.removeAttribute('role')\n\n      if (!this._config.scroll) {\n        new ScrollBarHelper().reset()\n      }\n\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    }\n\n    this._queueCallback(completeCallback, this._element, true)\n  }\n\n  dispose() {\n    this._backdrop.dispose()\n    this._focustrap.deactivate()\n    super.dispose()\n  }\n\n  // Private\n  _initializeBackDrop() {\n    const clickCallback = () => {\n      if (this._config.backdrop === 'static') {\n        EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n        return\n      }\n\n      this.hide()\n    }\n\n    // 'static' option will be translated to true, and booleans will keep their value\n    const isVisible = Boolean(this._config.backdrop)\n\n    return new Backdrop({\n      className: CLASS_NAME_BACKDROP,\n      isVisible,\n      isAnimated: true,\n      rootElement: this._element.parentNode,\n      clickCallback: isVisible ? clickCallback : null\n    })\n  }\n\n  _initializeFocusTrap() {\n    return new FocusTrap({\n      trapElement: this._element\n    })\n  }\n\n  _addEventListeners() {\n    EventHandler.on(this._element, EVENT_KEYDOWN_DISMISS, event => {\n      if (event.key !== ESCAPE_KEY) {\n        return\n      }\n\n      if (this._config.keyboard) {\n        this.hide()\n        return\n      }\n\n      EventHandler.trigger(this._element, EVENT_HIDE_PREVENTED)\n    })\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Offcanvas.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config](this)\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  const target = SelectorEngine.getElementFromSelector(this)\n\n  if (['A', 'AREA'].includes(this.tagName)) {\n    event.preventDefault()\n  }\n\n  if (isDisabled(this)) {\n    return\n  }\n\n  EventHandler.one(target, EVENT_HIDDEN, () => {\n    // focus on trigger when it is closed\n    if (isVisible(this)) {\n      this.focus()\n    }\n  })\n\n  // avoid conflict when clicking a toggler of an offcanvas, while another is open\n  const alreadyOpen = SelectorEngine.findOne(OPEN_SELECTOR)\n  if (alreadyOpen && alreadyOpen !== target) {\n    Offcanvas.getInstance(alreadyOpen).hide()\n  }\n\n  const data = Offcanvas.getOrCreateInstance(target)\n  data.toggle(this)\n})\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  for (const selector of SelectorEngine.find(OPEN_SELECTOR)) {\n    Offcanvas.getOrCreateInstance(selector).show()\n  }\n})\n\nEventHandler.on(window, EVENT_RESIZE, () => {\n  for (const element of SelectorEngine.find('[aria-modal][class*=show][class*=offcanvas-]')) {\n    if (getComputedStyle(element).position !== 'fixed') {\n      Offcanvas.getOrCreateInstance(element).hide()\n    }\n  }\n})\n\nenableDismissTrigger(Offcanvas)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Offcanvas)\n\nexport default Offcanvas\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/sanitizer.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\n// js-docs-start allow-list\nconst ARIA_ATTRIBUTE_PATTERN = /^aria-[\\w-]*$/i\n\nexport const DefaultAllowlist = {\n  // Global attributes allowed on any supplied element below.\n  '*': ['class', 'dir', 'id', 'lang', 'role', ARIA_ATTRIBUTE_PATTERN],\n  a: ['target', 'href', 'title', 'rel'],\n  area: [],\n  b: [],\n  br: [],\n  col: [],\n  code: [],\n  div: [],\n  em: [],\n  hr: [],\n  h1: [],\n  h2: [],\n  h3: [],\n  h4: [],\n  h5: [],\n  h6: [],\n  i: [],\n  img: ['src', 'srcset', 'alt', 'title', 'width', 'height'],\n  li: [],\n  ol: [],\n  p: [],\n  pre: [],\n  s: [],\n  small: [],\n  span: [],\n  sub: [],\n  sup: [],\n  strong: [],\n  u: [],\n  ul: []\n}\n// js-docs-end allow-list\n\nconst uriAttributes = new Set([\n  'background',\n  'cite',\n  'href',\n  'itemtype',\n  'longdesc',\n  'poster',\n  'src',\n  'xlink:href'\n])\n\n/**\n * A pattern that recognizes URLs that are safe wrt. XSS in URL navigation\n * contexts.\n *\n * Shout-out to Angular https://github.com/angular/angular/blob/15.2.8/packages/core/src/sanitization/url_sanitizer.ts#L38\n */\n// eslint-disable-next-line unicorn/better-regex\nconst SAFE_URL_PATTERN = /^(?!javascript:)(?:[a-z0-9+.-]+:|[^&:/?#]*(?:[/?#]|$))/i\n\nconst allowedAttribute = (attribute, allowedAttributeList) => {\n  const attributeName = attribute.nodeName.toLowerCase()\n\n  if (allowedAttributeList.includes(attributeName)) {\n    if (uriAttributes.has(attributeName)) {\n      return Boolean(SAFE_URL_PATTERN.test(attribute.nodeValue))\n    }\n\n    return true\n  }\n\n  // Check if a regular expression validates the attribute.\n  return allowedAttributeList.filter(attributeRegex => attributeRegex instanceof RegExp)\n    .some(regex => regex.test(attributeName))\n}\n\nexport function sanitizeHtml(unsafeHtml, allowList, sanitizeFunction) {\n  if (!unsafeHtml.length) {\n    return unsafeHtml\n  }\n\n  if (sanitizeFunction && typeof sanitizeFunction === 'function') {\n    return sanitizeFunction(unsafeHtml)\n  }\n\n  const domParser = new window.DOMParser()\n  const createdDocument = domParser.parseFromString(unsafeHtml, 'text/html')\n  const elements = [].concat(...createdDocument.body.querySelectorAll('*'))\n\n  for (const element of elements) {\n    const elementName = element.nodeName.toLowerCase()\n\n    if (!Object.keys(allowList).includes(elementName)) {\n      element.remove()\n      continue\n    }\n\n    const attributeList = [].concat(...element.attributes)\n    const allowedAttributes = [].concat(allowList['*'] || [], allowList[elementName] || [])\n\n    for (const attribute of attributeList) {\n      if (!allowedAttribute(attribute, allowedAttributes)) {\n        element.removeAttribute(attribute.nodeName)\n      }\n    }\n  }\n\n  return createdDocument.body.innerHTML\n}\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap util/template-factory.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport SelectorEngine from '../dom/selector-engine.js'\nimport Config from './config.js'\nimport { DefaultAllowlist, sanitizeHtml } from './sanitizer.js'\nimport { execute, getElement, isElement } from './index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'TemplateFactory'\n\nconst Default = {\n  allowList: DefaultAllowlist,\n  content: {}, // { selector : text ,  selector2 : text2 , }\n  extraClass: '',\n  html: false,\n  sanitize: true,\n  sanitizeFn: null,\n  template: '<div></div>'\n}\n\nconst DefaultType = {\n  allowList: 'object',\n  content: 'object',\n  extraClass: '(string|function)',\n  html: 'boolean',\n  sanitize: 'boolean',\n  sanitizeFn: '(null|function)',\n  template: 'string'\n}\n\nconst DefaultContentType = {\n  entry: '(string|element|function|null)',\n  selector: '(string|element)'\n}\n\n/**\n * Class definition\n */\n\nclass TemplateFactory extends Config {\n  constructor(config) {\n    super()\n    this._config = this._getConfig(config)\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  getContent() {\n    return Object.values(this._config.content)\n      .map(config => this._resolvePossibleFunction(config))\n      .filter(Boolean)\n  }\n\n  hasContent() {\n    return this.getContent().length > 0\n  }\n\n  changeContent(content) {\n    this._checkContent(content)\n    this._config.content = { ...this._config.content, ...content }\n    return this\n  }\n\n  toHtml() {\n    const templateWrapper = document.createElement('div')\n    templateWrapper.innerHTML = this._maybeSanitize(this._config.template)\n\n    for (const [selector, text] of Object.entries(this._config.content)) {\n      this._setContent(templateWrapper, text, selector)\n    }\n\n    const template = templateWrapper.children[0]\n    const extraClass = this._resolvePossibleFunction(this._config.extraClass)\n\n    if (extraClass) {\n      template.classList.add(...extraClass.split(' '))\n    }\n\n    return template\n  }\n\n  // Private\n  _typeCheckConfig(config) {\n    super._typeCheckConfig(config)\n    this._checkContent(config.content)\n  }\n\n  _checkContent(arg) {\n    for (const [selector, content] of Object.entries(arg)) {\n      super._typeCheckConfig({ selector, entry: content }, DefaultContentType)\n    }\n  }\n\n  _setContent(template, content, selector) {\n    const templateElement = SelectorEngine.findOne(selector, template)\n\n    if (!templateElement) {\n      return\n    }\n\n    content = this._resolvePossibleFunction(content)\n\n    if (!content) {\n      templateElement.remove()\n      return\n    }\n\n    if (isElement(content)) {\n      this._putElementInTemplate(getElement(content), templateElement)\n      return\n    }\n\n    if (this._config.html) {\n      templateElement.innerHTML = this._maybeSanitize(content)\n      return\n    }\n\n    templateElement.textContent = content\n  }\n\n  _maybeSanitize(arg) {\n    return this._config.sanitize ? sanitizeHtml(arg, this._config.allowList, this._config.sanitizeFn) : arg\n  }\n\n  _resolvePossibleFunction(arg) {\n    return execute(arg, [this])\n  }\n\n  _putElementInTemplate(element, templateElement) {\n    if (this._config.html) {\n      templateElement.innerHTML = ''\n      templateElement.append(element)\n      return\n    }\n\n    templateElement.textContent = element.textContent\n  }\n}\n\nexport default TemplateFactory\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap tooltip.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport * as Popper from '@popperjs/core'\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport Manipulator from './dom/manipulator.js'\nimport { defineJQueryPlugin, execute, findShadowRoot, getElement, getUID, isRTL, noop } from './util/index.js'\nimport { DefaultAllowlist } from './util/sanitizer.js'\nimport TemplateFactory from './util/template-factory.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'tooltip'\nconst DISALLOWED_ATTRIBUTES = new Set(['sanitize', 'allowList', 'sanitizeFn'])\n\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_MODAL = 'modal'\nconst CLASS_NAME_SHOW = 'show'\n\nconst SELECTOR_TOOLTIP_INNER = '.tooltip-inner'\nconst SELECTOR_MODAL = `.${CLASS_NAME_MODAL}`\n\nconst EVENT_MODAL_HIDE = 'hide.bs.modal'\n\nconst TRIGGER_HOVER = 'hover'\nconst TRIGGER_FOCUS = 'focus'\nconst TRIGGER_CLICK = 'click'\nconst TRIGGER_MANUAL = 'manual'\n\nconst EVENT_HIDE = 'hide'\nconst EVENT_HIDDEN = 'hidden'\nconst EVENT_SHOW = 'show'\nconst EVENT_SHOWN = 'shown'\nconst EVENT_INSERTED = 'inserted'\nconst EVENT_CLICK = 'click'\nconst EVENT_FOCUSIN = 'focusin'\nconst EVENT_FOCUSOUT = 'focusout'\nconst EVENT_MOUSEENTER = 'mouseenter'\nconst EVENT_MOUSELEAVE = 'mouseleave'\n\nconst AttachmentMap = {\n  AUTO: 'auto',\n  TOP: 'top',\n  RIGHT: isRTL() ? 'left' : 'right',\n  BOTTOM: 'bottom',\n  LEFT: isRTL() ? 'right' : 'left'\n}\n\nconst Default = {\n  allowList: DefaultAllowlist,\n  animation: true,\n  boundary: 'clippingParents',\n  container: false,\n  customClass: '',\n  delay: 0,\n  fallbackPlacements: ['top', 'right', 'bottom', 'left'],\n  html: false,\n  offset: [0, 6],\n  placement: 'top',\n  popperConfig: null,\n  sanitize: true,\n  sanitizeFn: null,\n  selector: false,\n  template: '<div class=\"tooltip\" role=\"tooltip\">' +\n            '<div class=\"tooltip-arrow\"></div>' +\n            '<div class=\"tooltip-inner\"></div>' +\n            '</div>',\n  title: '',\n  trigger: 'hover focus'\n}\n\nconst DefaultType = {\n  allowList: 'object',\n  animation: 'boolean',\n  boundary: '(string|element)',\n  container: '(string|element|boolean)',\n  customClass: '(string|function)',\n  delay: '(number|object)',\n  fallbackPlacements: 'array',\n  html: 'boolean',\n  offset: '(array|string|function)',\n  placement: '(string|function)',\n  popperConfig: '(null|object|function)',\n  sanitize: 'boolean',\n  sanitizeFn: '(null|function)',\n  selector: '(string|boolean)',\n  template: 'string',\n  title: '(string|element|function)',\n  trigger: 'string'\n}\n\n/**\n * Class definition\n */\n\nclass Tooltip extends BaseComponent {\n  constructor(element, config) {\n    if (typeof Popper === 'undefined') {\n      throw new TypeError('Bootstrap\\'s tooltips require Popper (https://popper.js.org)')\n    }\n\n    super(element, config)\n\n    // Private\n    this._isEnabled = true\n    this._timeout = 0\n    this._isHovered = null\n    this._activeTrigger = {}\n    this._popper = null\n    this._templateFactory = null\n    this._newContent = null\n\n    // Protected\n    this.tip = null\n\n    this._setListeners()\n\n    if (!this._config.selector) {\n      this._fixTitle()\n    }\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  enable() {\n    this._isEnabled = true\n  }\n\n  disable() {\n    this._isEnabled = false\n  }\n\n  toggleEnabled() {\n    this._isEnabled = !this._isEnabled\n  }\n\n  toggle() {\n    if (!this._isEnabled) {\n      return\n    }\n\n    this._activeTrigger.click = !this._activeTrigger.click\n    if (this._isShown()) {\n      this._leave()\n      return\n    }\n\n    this._enter()\n  }\n\n  dispose() {\n    clearTimeout(this._timeout)\n\n    EventHandler.off(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n\n    if (this._element.getAttribute('data-bs-original-title')) {\n      this._element.setAttribute('title', this._element.getAttribute('data-bs-original-title'))\n    }\n\n    this._disposePopper()\n    super.dispose()\n  }\n\n  show() {\n    if (this._element.style.display === 'none') {\n      throw new Error('Please use show on visible elements')\n    }\n\n    if (!(this._isWithContent() && this._isEnabled)) {\n      return\n    }\n\n    const showEvent = EventHandler.trigger(this._element, this.constructor.eventName(EVENT_SHOW))\n    const shadowRoot = findShadowRoot(this._element)\n    const isInTheDom = (shadowRoot || this._element.ownerDocument.documentElement).contains(this._element)\n\n    if (showEvent.defaultPrevented || !isInTheDom) {\n      return\n    }\n\n    // TODO: v6 remove this or make it optional\n    this._disposePopper()\n\n    const tip = this._getTipElement()\n\n    this._element.setAttribute('aria-describedby', tip.getAttribute('id'))\n\n    const { container } = this._config\n\n    if (!this._element.ownerDocument.documentElement.contains(this.tip)) {\n      container.append(tip)\n      EventHandler.trigger(this._element, this.constructor.eventName(EVENT_INSERTED))\n    }\n\n    this._popper = this._createPopper(tip)\n\n    tip.classList.add(CLASS_NAME_SHOW)\n\n    // If this is a touch-enabled device we add extra\n    // empty mouseover listeners to the body's immediate children;\n    // only needed because of broken event delegation on iOS\n    // https://www.quirksmode.org/blog/archives/2014/02/mouse_event_bub.html\n    if ('ontouchstart' in document.documentElement) {\n      for (const element of [].concat(...document.body.children)) {\n        EventHandler.on(element, 'mouseover', noop)\n      }\n    }\n\n    const complete = () => {\n      EventHandler.trigger(this._element, this.constructor.eventName(EVENT_SHOWN))\n\n      if (this._isHovered === false) {\n        this._leave()\n      }\n\n      this._isHovered = false\n    }\n\n    this._queueCallback(complete, this.tip, this._isAnimated())\n  }\n\n  hide() {\n    if (!this._isShown()) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, this.constructor.eventName(EVENT_HIDE))\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    const tip = this._getTipElement()\n    tip.classList.remove(CLASS_NAME_SHOW)\n\n    // If this is a touch-enabled device we remove the extra\n    // empty mouseover listeners we added for iOS support\n    if ('ontouchstart' in document.documentElement) {\n      for (const element of [].concat(...document.body.children)) {\n        EventHandler.off(element, 'mouseover', noop)\n      }\n    }\n\n    this._activeTrigger[TRIGGER_CLICK] = false\n    this._activeTrigger[TRIGGER_FOCUS] = false\n    this._activeTrigger[TRIGGER_HOVER] = false\n    this._isHovered = null // it is a trick to support manual triggering\n\n    const complete = () => {\n      if (this._isWithActiveTrigger()) {\n        return\n      }\n\n      if (!this._isHovered) {\n        this._disposePopper()\n      }\n\n      this._element.removeAttribute('aria-describedby')\n      EventHandler.trigger(this._element, this.constructor.eventName(EVENT_HIDDEN))\n    }\n\n    this._queueCallback(complete, this.tip, this._isAnimated())\n  }\n\n  update() {\n    if (this._popper) {\n      this._popper.update()\n    }\n  }\n\n  // Protected\n  _isWithContent() {\n    return Boolean(this._getTitle())\n  }\n\n  _getTipElement() {\n    if (!this.tip) {\n      this.tip = this._createTipElement(this._newContent || this._getContentForTemplate())\n    }\n\n    return this.tip\n  }\n\n  _createTipElement(content) {\n    const tip = this._getTemplateFactory(content).toHtml()\n\n    // TODO: remove this check in v6\n    if (!tip) {\n      return null\n    }\n\n    tip.classList.remove(CLASS_NAME_FADE, CLASS_NAME_SHOW)\n    // TODO: v6 the following can be achieved with CSS only\n    tip.classList.add(`bs-${this.constructor.NAME}-auto`)\n\n    const tipId = getUID(this.constructor.NAME).toString()\n\n    tip.setAttribute('id', tipId)\n\n    if (this._isAnimated()) {\n      tip.classList.add(CLASS_NAME_FADE)\n    }\n\n    return tip\n  }\n\n  setContent(content) {\n    this._newContent = content\n    if (this._isShown()) {\n      this._disposePopper()\n      this.show()\n    }\n  }\n\n  _getTemplateFactory(content) {\n    if (this._templateFactory) {\n      this._templateFactory.changeContent(content)\n    } else {\n      this._templateFactory = new TemplateFactory({\n        ...this._config,\n        // the `content` var has to be after `this._config`\n        // to override config.content in case of popover\n        content,\n        extraClass: this._resolvePossibleFunction(this._config.customClass)\n      })\n    }\n\n    return this._templateFactory\n  }\n\n  _getContentForTemplate() {\n    return {\n      [SELECTOR_TOOLTIP_INNER]: this._getTitle()\n    }\n  }\n\n  _getTitle() {\n    return this._resolvePossibleFunction(this._config.title) || this._element.getAttribute('data-bs-original-title')\n  }\n\n  // Private\n  _initializeOnDelegatedTarget(event) {\n    return this.constructor.getOrCreateInstance(event.delegateTarget, this._getDelegateConfig())\n  }\n\n  _isAnimated() {\n    return this._config.animation || (this.tip && this.tip.classList.contains(CLASS_NAME_FADE))\n  }\n\n  _isShown() {\n    return this.tip && this.tip.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  _createPopper(tip) {\n    const placement = execute(this._config.placement, [this, tip, this._element])\n    const attachment = AttachmentMap[placement.toUpperCase()]\n    return Popper.createPopper(this._element, tip, this._getPopperConfig(attachment))\n  }\n\n  _getOffset() {\n    const { offset } = this._config\n\n    if (typeof offset === 'string') {\n      return offset.split(',').map(value => Number.parseInt(value, 10))\n    }\n\n    if (typeof offset === 'function') {\n      return popperData => offset(popperData, this._element)\n    }\n\n    return offset\n  }\n\n  _resolvePossibleFunction(arg) {\n    return execute(arg, [this._element])\n  }\n\n  _getPopperConfig(attachment) {\n    const defaultBsPopperConfig = {\n      placement: attachment,\n      modifiers: [\n        {\n          name: 'flip',\n          options: {\n            fallbackPlacements: this._config.fallbackPlacements\n          }\n        },\n        {\n          name: 'offset',\n          options: {\n            offset: this._getOffset()\n          }\n        },\n        {\n          name: 'preventOverflow',\n          options: {\n            boundary: this._config.boundary\n          }\n        },\n        {\n          name: 'arrow',\n          options: {\n            element: `.${this.constructor.NAME}-arrow`\n          }\n        },\n        {\n          name: 'preSetPlacement',\n          enabled: true,\n          phase: 'beforeMain',\n          fn: data => {\n            // Pre-set Popper's placement attribute in order to read the arrow sizes properly.\n            // Otherwise, Popper mixes up the width and height dimensions since the initial arrow style is for top placement\n            this._getTipElement().setAttribute('data-popper-placement', data.state.placement)\n          }\n        }\n      ]\n    }\n\n    return {\n      ...defaultBsPopperConfig,\n      ...execute(this._config.popperConfig, [defaultBsPopperConfig])\n    }\n  }\n\n  _setListeners() {\n    const triggers = this._config.trigger.split(' ')\n\n    for (const trigger of triggers) {\n      if (trigger === 'click') {\n        EventHandler.on(this._element, this.constructor.eventName(EVENT_CLICK), this._config.selector, event => {\n          const context = this._initializeOnDelegatedTarget(event)\n          context.toggle()\n        })\n      } else if (trigger !== TRIGGER_MANUAL) {\n        const eventIn = trigger === TRIGGER_HOVER ?\n          this.constructor.eventName(EVENT_MOUSEENTER) :\n          this.constructor.eventName(EVENT_FOCUSIN)\n        const eventOut = trigger === TRIGGER_HOVER ?\n          this.constructor.eventName(EVENT_MOUSELEAVE) :\n          this.constructor.eventName(EVENT_FOCUSOUT)\n\n        EventHandler.on(this._element, eventIn, this._config.selector, event => {\n          const context = this._initializeOnDelegatedTarget(event)\n          context._activeTrigger[event.type === 'focusin' ? TRIGGER_FOCUS : TRIGGER_HOVER] = true\n          context._enter()\n        })\n        EventHandler.on(this._element, eventOut, this._config.selector, event => {\n          const context = this._initializeOnDelegatedTarget(event)\n          context._activeTrigger[event.type === 'focusout' ? TRIGGER_FOCUS : TRIGGER_HOVER] =\n            context._element.contains(event.relatedTarget)\n\n          context._leave()\n        })\n      }\n    }\n\n    this._hideModalHandler = () => {\n      if (this._element) {\n        this.hide()\n      }\n    }\n\n    EventHandler.on(this._element.closest(SELECTOR_MODAL), EVENT_MODAL_HIDE, this._hideModalHandler)\n  }\n\n  _fixTitle() {\n    const title = this._element.getAttribute('title')\n\n    if (!title) {\n      return\n    }\n\n    if (!this._element.getAttribute('aria-label') && !this._element.textContent.trim()) {\n      this._element.setAttribute('aria-label', title)\n    }\n\n    this._element.setAttribute('data-bs-original-title', title) // DO NOT USE IT. Is only for backwards compatibility\n    this._element.removeAttribute('title')\n  }\n\n  _enter() {\n    if (this._isShown() || this._isHovered) {\n      this._isHovered = true\n      return\n    }\n\n    this._isHovered = true\n\n    this._setTimeout(() => {\n      if (this._isHovered) {\n        this.show()\n      }\n    }, this._config.delay.show)\n  }\n\n  _leave() {\n    if (this._isWithActiveTrigger()) {\n      return\n    }\n\n    this._isHovered = false\n\n    this._setTimeout(() => {\n      if (!this._isHovered) {\n        this.hide()\n      }\n    }, this._config.delay.hide)\n  }\n\n  _setTimeout(handler, timeout) {\n    clearTimeout(this._timeout)\n    this._timeout = setTimeout(handler, timeout)\n  }\n\n  _isWithActiveTrigger() {\n    return Object.values(this._activeTrigger).includes(true)\n  }\n\n  _getConfig(config) {\n    const dataAttributes = Manipulator.getDataAttributes(this._element)\n\n    for (const dataAttribute of Object.keys(dataAttributes)) {\n      if (DISALLOWED_ATTRIBUTES.has(dataAttribute)) {\n        delete dataAttributes[dataAttribute]\n      }\n    }\n\n    config = {\n      ...dataAttributes,\n      ...(typeof config === 'object' && config ? config : {})\n    }\n    config = this._mergeConfigObj(config)\n    config = this._configAfterMerge(config)\n    this._typeCheckConfig(config)\n    return config\n  }\n\n  _configAfterMerge(config) {\n    config.container = config.container === false ? document.body : getElement(config.container)\n\n    if (typeof config.delay === 'number') {\n      config.delay = {\n        show: config.delay,\n        hide: config.delay\n      }\n    }\n\n    if (typeof config.title === 'number') {\n      config.title = config.title.toString()\n    }\n\n    if (typeof config.content === 'number') {\n      config.content = config.content.toString()\n    }\n\n    return config\n  }\n\n  _getDelegateConfig() {\n    const config = {}\n\n    for (const [key, value] of Object.entries(this._config)) {\n      if (this.constructor.Default[key] !== value) {\n        config[key] = value\n      }\n    }\n\n    config.selector = false\n    config.trigger = 'manual'\n\n    // In the future can be replaced with:\n    // const keysWithDifferentValues = Object.entries(this._config).filter(entry => this.constructor.Default[entry[0]] !== this._config[entry[0]])\n    // `Object.fromEntries(keysWithDifferentValues)`\n    return config\n  }\n\n  _disposePopper() {\n    if (this._popper) {\n      this._popper.destroy()\n      this._popper = null\n    }\n\n    if (this.tip) {\n      this.tip.remove()\n      this.tip = null\n    }\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Tooltip.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n}\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Tooltip)\n\nexport default Tooltip\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap popover.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Tooltip from './tooltip.js'\nimport { defineJQueryPlugin } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'popover'\n\nconst SELECTOR_TITLE = '.popover-header'\nconst SELECTOR_CONTENT = '.popover-body'\n\nconst Default = {\n  ...Tooltip.Default,\n  content: '',\n  offset: [0, 8],\n  placement: 'right',\n  template: '<div class=\"popover\" role=\"tooltip\">' +\n    '<div class=\"popover-arrow\"></div>' +\n    '<h3 class=\"popover-header\"></h3>' +\n    '<div class=\"popover-body\"></div>' +\n    '</div>',\n  trigger: 'click'\n}\n\nconst DefaultType = {\n  ...Tooltip.DefaultType,\n  content: '(null|string|element|function)'\n}\n\n/**\n * Class definition\n */\n\nclass Popover extends Tooltip {\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Overrides\n  _isWithContent() {\n    return this._getTitle() || this._getContent()\n  }\n\n  // Private\n  _getContentForTemplate() {\n    return {\n      [SELECTOR_TITLE]: this._getTitle(),\n      [SELECTOR_CONTENT]: this._getContent()\n    }\n  }\n\n  _getContent() {\n    return this._resolvePossibleFunction(this._config.content)\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Popover.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (typeof data[config] === 'undefined') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n}\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Popover)\n\nexport default Popover\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap scrollspy.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport { defineJQueryPlugin, getElement, isDisabled, isVisible } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'scrollspy'\nconst DATA_KEY = 'bs.scrollspy'\nconst EVENT_KEY = `.${DATA_KEY}`\nconst DATA_API_KEY = '.data-api'\n\nconst EVENT_ACTIVATE = `activate${EVENT_KEY}`\nconst EVENT_CLICK = `click${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}${DATA_API_KEY}`\n\nconst CLASS_NAME_DROPDOWN_ITEM = 'dropdown-item'\nconst CLASS_NAME_ACTIVE = 'active'\n\nconst SELECTOR_DATA_SPY = '[data-bs-spy=\"scroll\"]'\nconst SELECTOR_TARGET_LINKS = '[href]'\nconst SELECTOR_NAV_LIST_GROUP = '.nav, .list-group'\nconst SELECTOR_NAV_LINKS = '.nav-link'\nconst SELECTOR_NAV_ITEMS = '.nav-item'\nconst SELECTOR_LIST_ITEMS = '.list-group-item'\nconst SELECTOR_LINK_ITEMS = `${SELECTOR_NAV_LINKS}, ${SELECTOR_NAV_ITEMS} > ${SELECTOR_NAV_LINKS}, ${SELECTOR_LIST_ITEMS}`\nconst SELECTOR_DROPDOWN = '.dropdown'\nconst SELECTOR_DROPDOWN_TOGGLE = '.dropdown-toggle'\n\nconst Default = {\n  offset: null, // TODO: v6 @deprecated, keep it for backwards compatibility reasons\n  rootMargin: '0px 0px -25%',\n  smoothScroll: false,\n  target: null,\n  threshold: [0.1, 0.5, 1]\n}\n\nconst DefaultType = {\n  offset: '(number|null)', // TODO v6 @deprecated, keep it for backwards compatibility reasons\n  rootMargin: 'string',\n  smoothScroll: 'boolean',\n  target: 'element',\n  threshold: 'array'\n}\n\n/**\n * Class definition\n */\n\nclass ScrollSpy extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    // this._element is the observablesContainer and config.target the menu links wrapper\n    this._targetLinks = new Map()\n    this._observableSections = new Map()\n    this._rootElement = getComputedStyle(this._element).overflowY === 'visible' ? null : this._element\n    this._activeTarget = null\n    this._observer = null\n    this._previousScrollData = {\n      visibleEntryTop: 0,\n      parentScrollTop: 0\n    }\n    this.refresh() // initialize\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  refresh() {\n    this._initializeTargetsAndObservables()\n    this._maybeEnableSmoothScroll()\n\n    if (this._observer) {\n      this._observer.disconnect()\n    } else {\n      this._observer = this._getNewObserver()\n    }\n\n    for (const section of this._observableSections.values()) {\n      this._observer.observe(section)\n    }\n  }\n\n  dispose() {\n    this._observer.disconnect()\n    super.dispose()\n  }\n\n  // Private\n  _configAfterMerge(config) {\n    // TODO: on v6 target should be given explicitly & remove the {target: 'ss-target'} case\n    config.target = getElement(config.target) || document.body\n\n    // TODO: v6 Only for backwards compatibility reasons. Use rootMargin only\n    config.rootMargin = config.offset ? `${config.offset}px 0px -30%` : config.rootMargin\n\n    if (typeof config.threshold === 'string') {\n      config.threshold = config.threshold.split(',').map(value => Number.parseFloat(value))\n    }\n\n    return config\n  }\n\n  _maybeEnableSmoothScroll() {\n    if (!this._config.smoothScroll) {\n      return\n    }\n\n    // unregister any previous listeners\n    EventHandler.off(this._config.target, EVENT_CLICK)\n\n    EventHandler.on(this._config.target, EVENT_CLICK, SELECTOR_TARGET_LINKS, event => {\n      const observableSection = this._observableSections.get(event.target.hash)\n      if (observableSection) {\n        event.preventDefault()\n        const root = this._rootElement || window\n        const height = observableSection.offsetTop - this._element.offsetTop\n        if (root.scrollTo) {\n          root.scrollTo({ top: height, behavior: 'smooth' })\n          return\n        }\n\n        // Chrome 60 doesn't support `scrollTo`\n        root.scrollTop = height\n      }\n    })\n  }\n\n  _getNewObserver() {\n    const options = {\n      root: this._rootElement,\n      threshold: this._config.threshold,\n      rootMargin: this._config.rootMargin\n    }\n\n    return new IntersectionObserver(entries => this._observerCallback(entries), options)\n  }\n\n  // The logic of selection\n  _observerCallback(entries) {\n    const targetElement = entry => this._targetLinks.get(`#${entry.target.id}`)\n    const activate = entry => {\n      this._previousScrollData.visibleEntryTop = entry.target.offsetTop\n      this._process(targetElement(entry))\n    }\n\n    const parentScrollTop = (this._rootElement || document.documentElement).scrollTop\n    const userScrollsDown = parentScrollTop >= this._previousScrollData.parentScrollTop\n    this._previousScrollData.parentScrollTop = parentScrollTop\n\n    for (const entry of entries) {\n      if (!entry.isIntersecting) {\n        this._activeTarget = null\n        this._clearActiveClass(targetElement(entry))\n\n        continue\n      }\n\n      const entryIsLowerThanPrevious = entry.target.offsetTop >= this._previousScrollData.visibleEntryTop\n      // if we are scrolling down, pick the bigger offsetTop\n      if (userScrollsDown && entryIsLowerThanPrevious) {\n        activate(entry)\n        // if parent isn't scrolled, let's keep the first visible item, breaking the iteration\n        if (!parentScrollTop) {\n          return\n        }\n\n        continue\n      }\n\n      // if we are scrolling up, pick the smallest offsetTop\n      if (!userScrollsDown && !entryIsLowerThanPrevious) {\n        activate(entry)\n      }\n    }\n  }\n\n  _initializeTargetsAndObservables() {\n    this._targetLinks = new Map()\n    this._observableSections = new Map()\n\n    const targetLinks = SelectorEngine.find(SELECTOR_TARGET_LINKS, this._config.target)\n\n    for (const anchor of targetLinks) {\n      // ensure that the anchor has an id and is not disabled\n      if (!anchor.hash || isDisabled(anchor)) {\n        continue\n      }\n\n      const observableSection = SelectorEngine.findOne(decodeURI(anchor.hash), this._element)\n\n      // ensure that the observableSection exists & is visible\n      if (isVisible(observableSection)) {\n        this._targetLinks.set(decodeURI(anchor.hash), anchor)\n        this._observableSections.set(anchor.hash, observableSection)\n      }\n    }\n  }\n\n  _process(target) {\n    if (this._activeTarget === target) {\n      return\n    }\n\n    this._clearActiveClass(this._config.target)\n    this._activeTarget = target\n    target.classList.add(CLASS_NAME_ACTIVE)\n    this._activateParents(target)\n\n    EventHandler.trigger(this._element, EVENT_ACTIVATE, { relatedTarget: target })\n  }\n\n  _activateParents(target) {\n    // Activate dropdown parents\n    if (target.classList.contains(CLASS_NAME_DROPDOWN_ITEM)) {\n      SelectorEngine.findOne(SELECTOR_DROPDOWN_TOGGLE, target.closest(SELECTOR_DROPDOWN))\n        .classList.add(CLASS_NAME_ACTIVE)\n      return\n    }\n\n    for (const listGroup of SelectorEngine.parents(target, SELECTOR_NAV_LIST_GROUP)) {\n      // Set triggered links parents as active\n      // With both <ul> and <nav> markup a parent is the previous sibling of any nav ancestor\n      for (const item of SelectorEngine.prev(listGroup, SELECTOR_LINK_ITEMS)) {\n        item.classList.add(CLASS_NAME_ACTIVE)\n      }\n    }\n  }\n\n  _clearActiveClass(parent) {\n    parent.classList.remove(CLASS_NAME_ACTIVE)\n\n    const activeNodes = SelectorEngine.find(`${SELECTOR_TARGET_LINKS}.${CLASS_NAME_ACTIVE}`, parent)\n    for (const node of activeNodes) {\n      node.classList.remove(CLASS_NAME_ACTIVE)\n    }\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = ScrollSpy.getOrCreateInstance(this, config)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  for (const spy of SelectorEngine.find(SELECTOR_DATA_SPY)) {\n    ScrollSpy.getOrCreateInstance(spy)\n  }\n})\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(ScrollSpy)\n\nexport default ScrollSpy\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap tab.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport SelectorEngine from './dom/selector-engine.js'\nimport { defineJQueryPlugin, getNextActiveElement, isDisabled } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'tab'\nconst DATA_KEY = 'bs.tab'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\nconst EVENT_CLICK_DATA_API = `click${EVENT_KEY}`\nconst EVENT_KEYDOWN = `keydown${EVENT_KEY}`\nconst EVENT_LOAD_DATA_API = `load${EVENT_KEY}`\n\nconst ARROW_LEFT_KEY = 'ArrowLeft'\nconst ARROW_RIGHT_KEY = 'ArrowRight'\nconst ARROW_UP_KEY = 'ArrowUp'\nconst ARROW_DOWN_KEY = 'ArrowDown'\nconst HOME_KEY = 'Home'\nconst END_KEY = 'End'\n\nconst CLASS_NAME_ACTIVE = 'active'\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_DROPDOWN = 'dropdown'\n\nconst SELECTOR_DROPDOWN_TOGGLE = '.dropdown-toggle'\nconst SELECTOR_DROPDOWN_MENU = '.dropdown-menu'\nconst NOT_SELECTOR_DROPDOWN_TOGGLE = ':not(.dropdown-toggle)'\n\nconst SELECTOR_TAB_PANEL = '.list-group, .nav, [role=\"tablist\"]'\nconst SELECTOR_OUTER = '.nav-item, .list-group-item'\nconst SELECTOR_INNER = `.nav-link${NOT_SELECTOR_DROPDOWN_TOGGLE}, .list-group-item${NOT_SELECTOR_DROPDOWN_TOGGLE}, [role=\"tab\"]${NOT_SELECTOR_DROPDOWN_TOGGLE}`\nconst SELECTOR_DATA_TOGGLE = '[data-bs-toggle=\"tab\"], [data-bs-toggle=\"pill\"], [data-bs-toggle=\"list\"]' // TODO: could only be `tab` in v6\nconst SELECTOR_INNER_ELEM = `${SELECTOR_INNER}, ${SELECTOR_DATA_TOGGLE}`\n\nconst SELECTOR_DATA_TOGGLE_ACTIVE = `.${CLASS_NAME_ACTIVE}[data-bs-toggle=\"tab\"], .${CLASS_NAME_ACTIVE}[data-bs-toggle=\"pill\"], .${CLASS_NAME_ACTIVE}[data-bs-toggle=\"list\"]`\n\n/**\n * Class definition\n */\n\nclass Tab extends BaseComponent {\n  constructor(element) {\n    super(element)\n    this._parent = this._element.closest(SELECTOR_TAB_PANEL)\n\n    if (!this._parent) {\n      return\n      // TODO: should throw exception in v6\n      // throw new TypeError(`${element.outerHTML} has not a valid parent ${SELECTOR_INNER_ELEM}`)\n    }\n\n    // Set up initial aria attributes\n    this._setInitialAttributes(this._parent, this._getChildren())\n\n    EventHandler.on(this._element, EVENT_KEYDOWN, event => this._keydown(event))\n  }\n\n  // Getters\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  show() { // Shows this elem and deactivate the active sibling if exists\n    const innerElem = this._element\n    if (this._elemIsActive(innerElem)) {\n      return\n    }\n\n    // Search for active tab on same parent to deactivate it\n    const active = this._getActiveElem()\n\n    const hideEvent = active ?\n      EventHandler.trigger(active, EVENT_HIDE, { relatedTarget: innerElem }) :\n      null\n\n    const showEvent = EventHandler.trigger(innerElem, EVENT_SHOW, { relatedTarget: active })\n\n    if (showEvent.defaultPrevented || (hideEvent && hideEvent.defaultPrevented)) {\n      return\n    }\n\n    this._deactivate(active, innerElem)\n    this._activate(innerElem, active)\n  }\n\n  // Private\n  _activate(element, relatedElem) {\n    if (!element) {\n      return\n    }\n\n    element.classList.add(CLASS_NAME_ACTIVE)\n\n    this._activate(SelectorEngine.getElementFromSelector(element)) // Search and activate/show the proper section\n\n    const complete = () => {\n      if (element.getAttribute('role') !== 'tab') {\n        element.classList.add(CLASS_NAME_SHOW)\n        return\n      }\n\n      element.removeAttribute('tabindex')\n      element.setAttribute('aria-selected', true)\n      this._toggleDropDown(element, true)\n      EventHandler.trigger(element, EVENT_SHOWN, {\n        relatedTarget: relatedElem\n      })\n    }\n\n    this._queueCallback(complete, element, element.classList.contains(CLASS_NAME_FADE))\n  }\n\n  _deactivate(element, relatedElem) {\n    if (!element) {\n      return\n    }\n\n    element.classList.remove(CLASS_NAME_ACTIVE)\n    element.blur()\n\n    this._deactivate(SelectorEngine.getElementFromSelector(element)) // Search and deactivate the shown section too\n\n    const complete = () => {\n      if (element.getAttribute('role') !== 'tab') {\n        element.classList.remove(CLASS_NAME_SHOW)\n        return\n      }\n\n      element.setAttribute('aria-selected', false)\n      element.setAttribute('tabindex', '-1')\n      this._toggleDropDown(element, false)\n      EventHandler.trigger(element, EVENT_HIDDEN, { relatedTarget: relatedElem })\n    }\n\n    this._queueCallback(complete, element, element.classList.contains(CLASS_NAME_FADE))\n  }\n\n  _keydown(event) {\n    if (!([ARROW_LEFT_KEY, ARROW_RIGHT_KEY, ARROW_UP_KEY, ARROW_DOWN_KEY, HOME_KEY, END_KEY].includes(event.key))) {\n      return\n    }\n\n    event.stopPropagation()// stopPropagation/preventDefault both added to support up/down keys without scrolling the page\n    event.preventDefault()\n\n    const children = this._getChildren().filter(element => !isDisabled(element))\n    let nextActiveElement\n\n    if ([HOME_KEY, END_KEY].includes(event.key)) {\n      nextActiveElement = children[event.key === HOME_KEY ? 0 : children.length - 1]\n    } else {\n      const isNext = [ARROW_RIGHT_KEY, ARROW_DOWN_KEY].includes(event.key)\n      nextActiveElement = getNextActiveElement(children, event.target, isNext, true)\n    }\n\n    if (nextActiveElement) {\n      nextActiveElement.focus({ preventScroll: true })\n      Tab.getOrCreateInstance(nextActiveElement).show()\n    }\n  }\n\n  _getChildren() { // collection of inner elements\n    return SelectorEngine.find(SELECTOR_INNER_ELEM, this._parent)\n  }\n\n  _getActiveElem() {\n    return this._getChildren().find(child => this._elemIsActive(child)) || null\n  }\n\n  _setInitialAttributes(parent, children) {\n    this._setAttributeIfNotExists(parent, 'role', 'tablist')\n\n    for (const child of children) {\n      this._setInitialAttributesOnChild(child)\n    }\n  }\n\n  _setInitialAttributesOnChild(child) {\n    child = this._getInnerElement(child)\n    const isActive = this._elemIsActive(child)\n    const outerElem = this._getOuterElement(child)\n    child.setAttribute('aria-selected', isActive)\n\n    if (outerElem !== child) {\n      this._setAttributeIfNotExists(outerElem, 'role', 'presentation')\n    }\n\n    if (!isActive) {\n      child.setAttribute('tabindex', '-1')\n    }\n\n    this._setAttributeIfNotExists(child, 'role', 'tab')\n\n    // set attributes to the related panel too\n    this._setInitialAttributesOnTargetPanel(child)\n  }\n\n  _setInitialAttributesOnTargetPanel(child) {\n    const target = SelectorEngine.getElementFromSelector(child)\n\n    if (!target) {\n      return\n    }\n\n    this._setAttributeIfNotExists(target, 'role', 'tabpanel')\n\n    if (child.id) {\n      this._setAttributeIfNotExists(target, 'aria-labelledby', `${child.id}`)\n    }\n  }\n\n  _toggleDropDown(element, open) {\n    const outerElem = this._getOuterElement(element)\n    if (!outerElem.classList.contains(CLASS_DROPDOWN)) {\n      return\n    }\n\n    const toggle = (selector, className) => {\n      const element = SelectorEngine.findOne(selector, outerElem)\n      if (element) {\n        element.classList.toggle(className, open)\n      }\n    }\n\n    toggle(SELECTOR_DROPDOWN_TOGGLE, CLASS_NAME_ACTIVE)\n    toggle(SELECTOR_DROPDOWN_MENU, CLASS_NAME_SHOW)\n    outerElem.setAttribute('aria-expanded', open)\n  }\n\n  _setAttributeIfNotExists(element, attribute, value) {\n    if (!element.hasAttribute(attribute)) {\n      element.setAttribute(attribute, value)\n    }\n  }\n\n  _elemIsActive(elem) {\n    return elem.classList.contains(CLASS_NAME_ACTIVE)\n  }\n\n  // Try to get the inner element (usually the .nav-link)\n  _getInnerElement(elem) {\n    return elem.matches(SELECTOR_INNER_ELEM) ? elem : SelectorEngine.findOne(SELECTOR_INNER_ELEM, elem)\n  }\n\n  // Try to get the outer element (usually the .nav-item)\n  _getOuterElement(elem) {\n    return elem.closest(SELECTOR_OUTER) || elem\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Tab.getOrCreateInstance(this)\n\n      if (typeof config !== 'string') {\n        return\n      }\n\n      if (data[config] === undefined || config.startsWith('_') || config === 'constructor') {\n        throw new TypeError(`No method named \"${config}\"`)\n      }\n\n      data[config]()\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nEventHandler.on(document, EVENT_CLICK_DATA_API, SELECTOR_DATA_TOGGLE, function (event) {\n  if (['A', 'AREA'].includes(this.tagName)) {\n    event.preventDefault()\n  }\n\n  if (isDisabled(this)) {\n    return\n  }\n\n  Tab.getOrCreateInstance(this).show()\n})\n\n/**\n * Initialize on focus\n */\nEventHandler.on(window, EVENT_LOAD_DATA_API, () => {\n  for (const element of SelectorEngine.find(SELECTOR_DATA_TOGGLE_ACTIVE)) {\n    Tab.getOrCreateInstance(element)\n  }\n})\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Tab)\n\nexport default Tab\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap toast.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport BaseComponent from './base-component.js'\nimport EventHandler from './dom/event-handler.js'\nimport { enableDismissTrigger } from './util/component-functions.js'\nimport { defineJQueryPlugin, reflow } from './util/index.js'\n\n/**\n * Constants\n */\n\nconst NAME = 'toast'\nconst DATA_KEY = 'bs.toast'\nconst EVENT_KEY = `.${DATA_KEY}`\n\nconst EVENT_MOUSEOVER = `mouseover${EVENT_KEY}`\nconst EVENT_MOUSEOUT = `mouseout${EVENT_KEY}`\nconst EVENT_FOCUSIN = `focusin${EVENT_KEY}`\nconst EVENT_FOCUSOUT = `focusout${EVENT_KEY}`\nconst EVENT_HIDE = `hide${EVENT_KEY}`\nconst EVENT_HIDDEN = `hidden${EVENT_KEY}`\nconst EVENT_SHOW = `show${EVENT_KEY}`\nconst EVENT_SHOWN = `shown${EVENT_KEY}`\n\nconst CLASS_NAME_FADE = 'fade'\nconst CLASS_NAME_HIDE = 'hide' // @deprecated - kept here only for backwards compatibility\nconst CLASS_NAME_SHOW = 'show'\nconst CLASS_NAME_SHOWING = 'showing'\n\nconst DefaultType = {\n  animation: 'boolean',\n  autohide: 'boolean',\n  delay: 'number'\n}\n\nconst Default = {\n  animation: true,\n  autohide: true,\n  delay: 5000\n}\n\n/**\n * Class definition\n */\n\nclass Toast extends BaseComponent {\n  constructor(element, config) {\n    super(element, config)\n\n    this._timeout = null\n    this._hasMouseInteraction = false\n    this._hasKeyboardInteraction = false\n    this._setListeners()\n  }\n\n  // Getters\n  static get Default() {\n    return Default\n  }\n\n  static get DefaultType() {\n    return DefaultType\n  }\n\n  static get NAME() {\n    return NAME\n  }\n\n  // Public\n  show() {\n    const showEvent = EventHandler.trigger(this._element, EVENT_SHOW)\n\n    if (showEvent.defaultPrevented) {\n      return\n    }\n\n    this._clearTimeout()\n\n    if (this._config.animation) {\n      this._element.classList.add(CLASS_NAME_FADE)\n    }\n\n    const complete = () => {\n      this._element.classList.remove(CLASS_NAME_SHOWING)\n      EventHandler.trigger(this._element, EVENT_SHOWN)\n\n      this._maybeScheduleHide()\n    }\n\n    this._element.classList.remove(CLASS_NAME_HIDE) // @deprecated\n    reflow(this._element)\n    this._element.classList.add(CLASS_NAME_SHOW, CLASS_NAME_SHOWING)\n\n    this._queueCallback(complete, this._element, this._config.animation)\n  }\n\n  hide() {\n    if (!this.isShown()) {\n      return\n    }\n\n    const hideEvent = EventHandler.trigger(this._element, EVENT_HIDE)\n\n    if (hideEvent.defaultPrevented) {\n      return\n    }\n\n    const complete = () => {\n      this._element.classList.add(CLASS_NAME_HIDE) // @deprecated\n      this._element.classList.remove(CLASS_NAME_SHOWING, CLASS_NAME_SHOW)\n      EventHandler.trigger(this._element, EVENT_HIDDEN)\n    }\n\n    this._element.classList.add(CLASS_NAME_SHOWING)\n    this._queueCallback(complete, this._element, this._config.animation)\n  }\n\n  dispose() {\n    this._clearTimeout()\n\n    if (this.isShown()) {\n      this._element.classList.remove(CLASS_NAME_SHOW)\n    }\n\n    super.dispose()\n  }\n\n  isShown() {\n    return this._element.classList.contains(CLASS_NAME_SHOW)\n  }\n\n  // Private\n\n  _maybeScheduleHide() {\n    if (!this._config.autohide) {\n      return\n    }\n\n    if (this._hasMouseInteraction || this._hasKeyboardInteraction) {\n      return\n    }\n\n    this._timeout = setTimeout(() => {\n      this.hide()\n    }, this._config.delay)\n  }\n\n  _onInteraction(event, isInteracting) {\n    switch (event.type) {\n      case 'mouseover':\n      case 'mouseout': {\n        this._hasMouseInteraction = isInteracting\n        break\n      }\n\n      case 'focusin':\n      case 'focusout': {\n        this._hasKeyboardInteraction = isInteracting\n        break\n      }\n\n      default: {\n        break\n      }\n    }\n\n    if (isInteracting) {\n      this._clearTimeout()\n      return\n    }\n\n    const nextElement = event.relatedTarget\n    if (this._element === nextElement || this._element.contains(nextElement)) {\n      return\n    }\n\n    this._maybeScheduleHide()\n  }\n\n  _setListeners() {\n    EventHandler.on(this._element, EVENT_MOUSEOVER, event => this._onInteraction(event, true))\n    EventHandler.on(this._element, EVENT_MOUSEOUT, event => this._onInteraction(event, false))\n    EventHandler.on(this._element, EVENT_FOCUSIN, event => this._onInteraction(event, true))\n    EventHandler.on(this._element, EVENT_FOCUSOUT, event => this._onInteraction(event, false))\n  }\n\n  _clearTimeout() {\n    clearTimeout(this._timeout)\n    this._timeout = null\n  }\n\n  // Static\n  static jQueryInterface(config) {\n    return this.each(function () {\n      const data = Toast.getOrCreateInstance(this, config)\n\n      if (typeof config === 'string') {\n        if (typeof data[config] === 'undefined') {\n          throw new TypeError(`No method named \"${config}\"`)\n        }\n\n        data[config](this)\n      }\n    })\n  }\n}\n\n/**\n * Data API implementation\n */\n\nenableDismissTrigger(Toast)\n\n/**\n * jQuery\n */\n\ndefineJQueryPlugin(Toast)\n\nexport default Toast\n","/**\n * --------------------------------------------------------------------------\n * Bootstrap index.umd.js\n * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)\n * --------------------------------------------------------------------------\n */\n\nimport Alert from './src/alert.js'\nimport Button from './src/button.js'\nimport Carousel from './src/carousel.js'\nimport Collapse from './src/collapse.js'\nimport Dropdown from './src/dropdown.js'\nimport Modal from './src/modal.js'\nimport Offcanvas from './src/offcanvas.js'\nimport Popover from './src/popover.js'\nimport ScrollSpy from './src/scrollspy.js'\nimport Tab from './src/tab.js'\nimport Toast from './src/toast.js'\nimport Tooltip from 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\ No newline at end of file
diff --git a/docs/deps/bootstrap-5.3.1/bootstrap.min.css b/docs/deps/bootstrap-5.3.1/bootstrap.min.css
new file mode 100644
index 0000000..9830088
--- /dev/null
+++ b/docs/deps/bootstrap-5.3.1/bootstrap.min.css
@@ -0,0 +1,5 @@
+:root{--bslib-bootstrap-version: 5;--bslib-preset-name: ;--bslib-preset-type: }/*!
+   * Bootstrap  v5.3.1 (https://getbootstrap.com/)
+   * Copyright 2011-2023 The Bootstrap Authors
+   * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)
+   */:root,[data-bs-theme="light"]{--bs-blue: #0d6efd;--bs-indigo: #6610f2;--bs-purple: #6f42c1;--bs-pink: #d63384;--bs-red: #dc3545;--bs-orange: #fd7e14;--bs-yellow: #ffc107;--bs-green: #198754;--bs-teal: #20c997;--bs-cyan: #0dcaf0;--bs-black: #000;--bs-white: #fff;--bs-gray: #6c757d;--bs-gray-dark: #343a40;--bs-gray-100: #f8f9fa;--bs-gray-200: #e9ecef;--bs-gray-300: #dee2e6;--bs-gray-400: #ced4da;--bs-gray-500: #adb5bd;--bs-gray-600: #6c757d;--bs-gray-700: #495057;--bs-gray-800: #343a40;--bs-gray-900: #212529;--bs-default: #dee2e6;--bs-primary: #0d6efd;--bs-secondary: #6c757d;--bs-success: #198754;--bs-info: #0dcaf0;--bs-warning: #ffc107;--bs-danger: #dc3545;--bs-light: #f8f9fa;--bs-dark: #212529;--bs-default-rgb: 222,226,230;--bs-primary-rgb: 13,110,253;--bs-secondary-rgb: 108,117,125;--bs-success-rgb: 25,135,84;--bs-info-rgb: 13,202,240;--bs-warning-rgb: 255,193,7;--bs-danger-rgb: 220,53,69;--bs-light-rgb: 248,249,250;--bs-dark-rgb: 33,37,41;--bs-primary-text-emphasis: 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auto}.btn-group>.btn-check:checked+.btn,.btn-group>.btn-check:focus+.btn,.btn-group>.btn:hover,.btn-group>.btn:focus,.btn-group>.btn:active,.btn-group>.btn.active,.btn-group-vertical>.btn-check:checked+.btn,.btn-group-vertical>.btn-check:focus+.btn,.btn-group-vertical>.btn:hover,.btn-group-vertical>.btn:focus,.btn-group-vertical>.btn:active,.btn-group-vertical>.btn.active{z-index:1}.btn-toolbar{display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;justify-content:flex-start;-webkit-justify-content:flex-start}.btn-toolbar .input-group{width:auto}.btn-group{border-radius:var(--bs-border-radius)}.btn-group>:not(.btn-check:first-child)+.btn,.btn-group>.btn-group:not(:first-child){margin-left:calc(var(--bs-border-width) * -1)}.btn-group>.btn:not(:last-child):not(.dropdown-toggle),.btn-group>.btn.dropdown-toggle-split:first-child,.btn-group>.btn-group:not(:last-child)>.btn{border-top-right-radius:0;border-bottom-right-radius:0}.btn-group>.btn:nth-child(n + 3),.btn-group>:not(.btn-check)+.btn,.btn-group>.btn-group:not(:first-child)>.btn{border-top-left-radius:0;border-bottom-left-radius:0}.dropdown-toggle-split{padding-right:.5625rem;padding-left:.5625rem}.dropdown-toggle-split::after,.dropup .dropdown-toggle-split::after,.dropend .dropdown-toggle-split::after{margin-left:0}.dropstart .dropdown-toggle-split::before{margin-right:0}.btn-sm+.dropdown-toggle-split,.btn-group-sm>.btn+.dropdown-toggle-split{padding-right:.375rem;padding-left:.375rem}.btn-lg+.dropdown-toggle-split,.btn-group-lg>.btn+.dropdown-toggle-split{padding-right:.75rem;padding-left:.75rem}.btn-group-vertical{flex-direction:column;-webkit-flex-direction:column;align-items:flex-start;-webkit-align-items:flex-start;justify-content:center;-webkit-justify-content:center}.btn-group-vertical>.btn,.btn-group-vertical>.btn-group{width:100%}.btn-group-vertical>.btn:not(:first-child),.btn-group-vertical>.btn-group:not(:first-child){margin-top:calc(var(--bs-border-width) * 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var(--bs-nav-link-padding-x);font-size:var(--bs-nav-link-font-size);font-weight:var(--bs-nav-link-font-weight);color:var(--bs-nav-link-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background:none;border:0;transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.nav-link{transition:none}}.nav-link:hover,.nav-link:focus{color:var(--bs-nav-link-hover-color)}.nav-link:focus-visible{outline:0;box-shadow:0 0 0 .25rem rgba(13,110,253,0.25)}.nav-link.disabled,.nav-link:disabled{color:var(--bs-nav-link-disabled-color);pointer-events:none;cursor:default}.nav-tabs{--bs-nav-tabs-border-width: var(--bs-border-width);--bs-nav-tabs-border-color: var(--bs-border-color);--bs-nav-tabs-border-radius: var(--bs-border-radius);--bs-nav-tabs-link-hover-border-color: var(--bs-secondary-bg) var(--bs-secondary-bg) var(--bs-border-color);--bs-nav-tabs-link-active-color: var(--bs-emphasis-color);--bs-nav-tabs-link-active-bg: var(--bs-body-bg);--bs-nav-tabs-link-active-border-color: var(--bs-border-color) var(--bs-border-color) var(--bs-body-bg);border-bottom:var(--bs-nav-tabs-border-width) solid var(--bs-nav-tabs-border-color)}.nav-tabs .nav-link{margin-bottom:calc(-1 * var(--bs-nav-tabs-border-width));border:var(--bs-nav-tabs-border-width) solid transparent;border-top-left-radius:var(--bs-nav-tabs-border-radius);border-top-right-radius:var(--bs-nav-tabs-border-radius)}.nav-tabs .nav-link:hover,.nav-tabs .nav-link:focus{isolation:isolate;border-color:var(--bs-nav-tabs-link-hover-border-color)}.nav-tabs .nav-link.active,.nav-tabs .nav-item.show .nav-link{color:var(--bs-nav-tabs-link-active-color);background-color:var(--bs-nav-tabs-link-active-bg);border-color:var(--bs-nav-tabs-link-active-border-color)}.nav-tabs .dropdown-menu{margin-top:calc(-1 * 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.offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-xxl .offcanvas .offcanvas-header{display:none}.navbar-expand-xxl .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}.navbar-expand{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand .navbar-nav .dropdown-menu{position:absolute}.navbar-expand .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand .navbar-nav-scroll{overflow:visible}.navbar-expand .navbar-collapse{display:flex !important;display:-webkit-flex 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.accordion-button.collapsed{border-bottom-right-radius:var(--bs-accordion-inner-border-radius);border-bottom-left-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:last-of-type .accordion-collapse{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse{border-width:0}.accordion-flush .accordion-item{border-right:0;border-left:0;border-radius:0}.accordion-flush .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child{border-bottom:0}.accordion-flush .accordion-item .accordion-button,.accordion-flush .accordion-item .accordion-button.collapsed{border-radius:0}[data-bs-theme="dark"] .accordion-button::after{--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%236ea8fe'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-active-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%236ea8fe'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e")}.breadcrumb{--bs-breadcrumb-padding-x: 0;--bs-breadcrumb-padding-y: 0;--bs-breadcrumb-margin-bottom: 1rem;--bs-breadcrumb-bg: ;--bs-breadcrumb-border-radius: ;--bs-breadcrumb-divider-color: var(--bs-secondary-color);--bs-breadcrumb-item-padding-x: .5rem;--bs-breadcrumb-item-active-color: var(--bs-secondary-color);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding:var(--bs-breadcrumb-padding-y) var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "/") /* rtl: var(--bs-breadcrumb-divider, "/") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: .75rem;--bs-pagination-padding-y: .375rem;--bs-pagination-font-size:1rem;--bs-pagination-color: var(--bs-link-color);--bs-pagination-bg: var(--bs-body-bg);--bs-pagination-border-width: var(--bs-border-width);--bs-pagination-border-color: var(--bs-border-color);--bs-pagination-border-radius: var(--bs-border-radius);--bs-pagination-hover-color: var(--bs-link-hover-color);--bs-pagination-hover-bg: var(--bs-tertiary-bg);--bs-pagination-hover-border-color: var(--bs-border-color);--bs-pagination-focus-color: var(--bs-link-hover-color);--bs-pagination-focus-bg: var(--bs-secondary-bg);--bs-pagination-focus-box-shadow: 0 0 0 .25rem rgba(13,110,253,0.25);--bs-pagination-active-color: #fff;--bs-pagination-active-bg: #0d6efd;--bs-pagination-active-border-color: #0d6efd;--bs-pagination-disabled-color: var(--bs-secondary-color);--bs-pagination-disabled-bg: var(--bs-secondary-bg);--bs-pagination-disabled-border-color: var(--bs-border-color);display:flex;display:-webkit-flex;padding-left:0;list-style:none}.page-link{position:relative;display:block;padding:var(--bs-pagination-padding-y) var(--bs-pagination-padding-x);font-size:var(--bs-pagination-font-size);color:var(--bs-pagination-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-pagination-bg);border:var(--bs-pagination-border-width) solid var(--bs-pagination-border-color);transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.page-link{transition:none}}.page-link:hover{z-index:2;color:var(--bs-pagination-hover-color);background-color:var(--bs-pagination-hover-bg);border-color:var(--bs-pagination-hover-border-color)}.page-link:focus{z-index:3;color:var(--bs-pagination-focus-color);background-color:var(--bs-pagination-focus-bg);outline:0;box-shadow:var(--bs-pagination-focus-box-shadow)}.page-link.active,.active>.page-link{z-index:3;color:var(--bs-pagination-active-color);background-color:var(--bs-pagination-active-bg);border-color:var(--bs-pagination-active-border-color)}.page-link.disabled,.disabled>.page-link{color:var(--bs-pagination-disabled-color);pointer-events:none;background-color:var(--bs-pagination-disabled-bg);border-color:var(--bs-pagination-disabled-border-color)}.page-item:not(:first-child) .page-link{margin-left:calc(var(--bs-border-width) * -1)}.page-item:first-child .page-link{border-top-left-radius:var(--bs-pagination-border-radius);border-bottom-left-radius:var(--bs-pagination-border-radius)}.page-item:last-child .page-link{border-top-right-radius:var(--bs-pagination-border-radius);border-bottom-right-radius:var(--bs-pagination-border-radius)}.pagination-lg{--bs-pagination-padding-x: 1.5rem;--bs-pagination-padding-y: .75rem;--bs-pagination-font-size:1.25rem;--bs-pagination-border-radius: var(--bs-border-radius-lg)}.pagination-sm{--bs-pagination-padding-x: .5rem;--bs-pagination-padding-y: .25rem;--bs-pagination-font-size:.875rem;--bs-pagination-border-radius: var(--bs-border-radius-sm)}.badge{--bs-badge-padding-x: .65em;--bs-badge-padding-y: .35em;--bs-badge-font-size:.75em;--bs-badge-font-weight: 700;--bs-badge-color: #fff;--bs-badge-border-radius: var(--bs-border-radius);display:inline-block;padding:var(--bs-badge-padding-y) var(--bs-badge-padding-x);font-size:var(--bs-badge-font-size);font-weight:var(--bs-badge-font-weight);line-height:1;color:var(--bs-badge-color);text-align:center;white-space:nowrap;vertical-align:baseline;border-radius:var(--bs-badge-border-radius)}.badge:empty{display:none}.btn .badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: var(--bs-border-width) solid var(--bs-alert-border-color);--bs-alert-border-radius: var(--bs-border-radius);--bs-alert-link-color: inherit;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700;color:var(--bs-alert-link-color)}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: var(--bs-default-text-emphasis);--bs-alert-bg: var(--bs-default-bg-subtle);--bs-alert-border-color: var(--bs-default-border-subtle);--bs-alert-link-color: var(--bs-default-text-emphasis)}.alert-primary{--bs-alert-color: var(--bs-primary-text-emphasis);--bs-alert-bg: var(--bs-primary-bg-subtle);--bs-alert-border-color: var(--bs-primary-border-subtle);--bs-alert-link-color: var(--bs-primary-text-emphasis)}.alert-secondary{--bs-alert-color: var(--bs-secondary-text-emphasis);--bs-alert-bg: var(--bs-secondary-bg-subtle);--bs-alert-border-color: var(--bs-secondary-border-subtle);--bs-alert-link-color: var(--bs-secondary-text-emphasis)}.alert-success{--bs-alert-color: var(--bs-success-text-emphasis);--bs-alert-bg: var(--bs-success-bg-subtle);--bs-alert-border-color: var(--bs-success-border-subtle);--bs-alert-link-color: var(--bs-success-text-emphasis)}.alert-info{--bs-alert-color: var(--bs-info-text-emphasis);--bs-alert-bg: var(--bs-info-bg-subtle);--bs-alert-border-color: var(--bs-info-border-subtle);--bs-alert-link-color: var(--bs-info-text-emphasis)}.alert-warning{--bs-alert-color: var(--bs-warning-text-emphasis);--bs-alert-bg: var(--bs-warning-bg-subtle);--bs-alert-border-color: var(--bs-warning-border-subtle);--bs-alert-link-color: var(--bs-warning-text-emphasis)}.alert-danger{--bs-alert-color: var(--bs-danger-text-emphasis);--bs-alert-bg: var(--bs-danger-bg-subtle);--bs-alert-border-color: var(--bs-danger-border-subtle);--bs-alert-link-color: var(--bs-danger-text-emphasis)}.alert-light{--bs-alert-color: var(--bs-light-text-emphasis);--bs-alert-bg: var(--bs-light-bg-subtle);--bs-alert-border-color: var(--bs-light-border-subtle);--bs-alert-link-color: var(--bs-light-text-emphasis)}.alert-dark{--bs-alert-color: var(--bs-dark-text-emphasis);--bs-alert-bg: var(--bs-dark-bg-subtle);--bs-alert-border-color: var(--bs-dark-border-subtle);--bs-alert-link-color: var(--bs-dark-text-emphasis)}@keyframes progress-bar-stripes{0%{background-position-x:1rem}}.progress,.progress-stacked{--bs-progress-height: 1rem;--bs-progress-font-size:.75rem;--bs-progress-bg: var(--bs-secondary-bg);--bs-progress-border-radius: var(--bs-border-radius);--bs-progress-box-shadow: var(--bs-box-shadow-inset);--bs-progress-bar-color: #fff;--bs-progress-bar-bg: #0d6efd;--bs-progress-bar-transition: width 0.6s ease;display:flex;display:-webkit-flex;height:var(--bs-progress-height);overflow:hidden;font-size:var(--bs-progress-font-size);background-color:var(--bs-progress-bg);border-radius:var(--bs-progress-border-radius)}.progress-bar{display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;justify-content:center;-webkit-justify-content:center;overflow:hidden;color:var(--bs-progress-bar-color);text-align:center;white-space:nowrap;background-color:var(--bs-progress-bar-bg);transition:var(--bs-progress-bar-transition)}@media (prefers-reduced-motion: reduce){.progress-bar{transition:none}}.progress-bar-striped{background-image:linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, transparent);background-size:var(--bs-progress-height) var(--bs-progress-height)}.progress-stacked>.progress{overflow:visible}.progress-stacked>.progress>.progress-bar{width:100%}.progress-bar-animated{animation:1s linear infinite progress-bar-stripes}@media (prefers-reduced-motion: reduce){.progress-bar-animated{animation:none}}.list-group{--bs-list-group-color: var(--bs-body-color);--bs-list-group-bg: var(--bs-body-bg);--bs-list-group-border-color: var(--bs-border-color);--bs-list-group-border-width: var(--bs-border-width);--bs-list-group-border-radius: var(--bs-border-radius);--bs-list-group-item-padding-x: 1rem;--bs-list-group-item-padding-y: .5rem;--bs-list-group-action-color: var(--bs-secondary-color);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-tertiary-bg);--bs-list-group-action-active-color: var(--bs-body-color);--bs-list-group-action-active-bg: var(--bs-secondary-bg);--bs-list-group-disabled-color: var(--bs-secondary-color);--bs-list-group-disabled-bg: var(--bs-body-bg);--bs-list-group-active-color: #fff;--bs-list-group-active-bg: #0d6efd;--bs-list-group-active-border-color: #0d6efd;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;padding-left:0;margin-bottom:0;border-radius:var(--bs-list-group-border-radius)}.list-group-numbered{list-style-type:none;counter-reset:section}.list-group-numbered>.list-group-item::before{content:counters(section, ".") ". ";counter-increment:section}.list-group-item-action{width:100%;color:var(--bs-list-group-action-color);text-align:inherit}.list-group-item-action:hover,.list-group-item-action:focus{z-index:1;color:var(--bs-list-group-action-hover-color);text-decoration:none;background-color:var(--bs-list-group-action-hover-bg)}.list-group-item-action:active{color:var(--bs-list-group-action-active-color);background-color:var(--bs-list-group-action-active-bg)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid var(--bs-list-group-border-color)}.list-group-item:first-child{border-top-left-radius:inherit;border-top-right-radius:inherit}.list-group-item:last-child{border-bottom-right-radius:inherit;border-bottom-left-radius:inherit}.list-group-item.disabled,.list-group-item:disabled{color:var(--bs-list-group-disabled-color);pointer-events:none;background-color:var(--bs-list-group-disabled-bg)}.list-group-item.active{z-index:2;color:var(--bs-list-group-active-color);background-color:var(--bs-list-group-active-bg);border-color:var(--bs-list-group-active-border-color)}.list-group-item+.list-group-item{border-top-width:0}.list-group-item+.list-group-item.active{margin-top:calc(-1 * var(--bs-list-group-border-width));border-top-width:var(--bs-list-group-border-width)}.list-group-horizontal{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal>.list-group-item.active{margin-top:0}.list-group-horizontal>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}@media (min-width: 576px){.list-group-horizontal-sm{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-sm>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-sm>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-sm>.list-group-item.active{margin-top:0}.list-group-horizontal-sm>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-sm>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 768px){.list-group-horizontal-md{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-md>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-md>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-md>.list-group-item.active{margin-top:0}.list-group-horizontal-md>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-md>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 992px){.list-group-horizontal-lg{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-lg>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-lg>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-lg>.list-group-item.active{margin-top:0}.list-group-horizontal-lg>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-lg>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1200px){.list-group-horizontal-xl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xl>.list-group-item.active{margin-top:0}.list-group-horizontal-xl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1400px){.list-group-horizontal-xxl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xxl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xxl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xxl>.list-group-item.active{margin-top:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}.list-group-flush{border-radius:0}.list-group-flush>.list-group-item{border-width:0 0 var(--bs-list-group-border-width)}.list-group-flush>.list-group-item:last-child{border-bottom-width:0}.list-group-item-default{--bs-list-group-color: var(--bs-default-text-emphasis);--bs-list-group-bg: var(--bs-default-bg-subtle);--bs-list-group-border-color: var(--bs-default-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-default-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-default-border-subtle);--bs-list-group-active-color: var(--bs-default-bg-subtle);--bs-list-group-active-bg: var(--bs-default-text-emphasis);--bs-list-group-active-border-color: var(--bs-default-text-emphasis)}.list-group-item-primary{--bs-list-group-color: var(--bs-primary-text-emphasis);--bs-list-group-bg: var(--bs-primary-bg-subtle);--bs-list-group-border-color: var(--bs-primary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-primary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-primary-border-subtle);--bs-list-group-active-color: var(--bs-primary-bg-subtle);--bs-list-group-active-bg: var(--bs-primary-text-emphasis);--bs-list-group-active-border-color: var(--bs-primary-text-emphasis)}.list-group-item-secondary{--bs-list-group-color: var(--bs-secondary-text-emphasis);--bs-list-group-bg: var(--bs-secondary-bg-subtle);--bs-list-group-border-color: var(--bs-secondary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-secondary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-secondary-border-subtle);--bs-list-group-active-color: var(--bs-secondary-bg-subtle);--bs-list-group-active-bg: var(--bs-secondary-text-emphasis);--bs-list-group-active-border-color: var(--bs-secondary-text-emphasis)}.list-group-item-success{--bs-list-group-color: var(--bs-success-text-emphasis);--bs-list-group-bg: var(--bs-success-bg-subtle);--bs-list-group-border-color: var(--bs-success-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-success-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-success-border-subtle);--bs-list-group-active-color: var(--bs-success-bg-subtle);--bs-list-group-active-bg: var(--bs-success-text-emphasis);--bs-list-group-active-border-color: var(--bs-success-text-emphasis)}.list-group-item-info{--bs-list-group-color: var(--bs-info-text-emphasis);--bs-list-group-bg: var(--bs-info-bg-subtle);--bs-list-group-border-color: var(--bs-info-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-info-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-info-border-subtle);--bs-list-group-active-color: var(--bs-info-bg-subtle);--bs-list-group-active-bg: var(--bs-info-text-emphasis);--bs-list-group-active-border-color: var(--bs-info-text-emphasis)}.list-group-item-warning{--bs-list-group-color: var(--bs-warning-text-emphasis);--bs-list-group-bg: var(--bs-warning-bg-subtle);--bs-list-group-border-color: var(--bs-warning-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-warning-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-warning-border-subtle);--bs-list-group-active-color: var(--bs-warning-bg-subtle);--bs-list-group-active-bg: var(--bs-warning-text-emphasis);--bs-list-group-active-border-color: var(--bs-warning-text-emphasis)}.list-group-item-danger{--bs-list-group-color: var(--bs-danger-text-emphasis);--bs-list-group-bg: var(--bs-danger-bg-subtle);--bs-list-group-border-color: var(--bs-danger-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-danger-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-danger-border-subtle);--bs-list-group-active-color: var(--bs-danger-bg-subtle);--bs-list-group-active-bg: var(--bs-danger-text-emphasis);--bs-list-group-active-border-color: var(--bs-danger-text-emphasis)}.list-group-item-light{--bs-list-group-color: var(--bs-light-text-emphasis);--bs-list-group-bg: var(--bs-light-bg-subtle);--bs-list-group-border-color: var(--bs-light-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-light-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-light-border-subtle);--bs-list-group-active-color: var(--bs-light-bg-subtle);--bs-list-group-active-bg: var(--bs-light-text-emphasis);--bs-list-group-active-border-color: var(--bs-light-text-emphasis)}.list-group-item-dark{--bs-list-group-color: var(--bs-dark-text-emphasis);--bs-list-group-bg: var(--bs-dark-bg-subtle);--bs-list-group-border-color: var(--bs-dark-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-dark-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-dark-border-subtle);--bs-list-group-active-color: var(--bs-dark-bg-subtle);--bs-list-group-active-bg: var(--bs-dark-text-emphasis);--bs-list-group-active-border-color: var(--bs-dark-text-emphasis)}.btn-close{--bs-btn-close-color: #000;--bs-btn-close-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23000'%3e%3cpath d='M.293.293a1 1 0 0 1 1.414 0L8 6.586 14.293.293a1 1 0 1 1 1.414 1.414L9.414 8l6.293 6.293a1 1 0 0 1-1.414 1.414L8 9.414l-6.293 6.293a1 1 0 0 1-1.414-1.414L6.586 8 .293 1.707a1 1 0 0 1 0-1.414z'/%3e%3c/svg%3e");--bs-btn-close-opacity: .5;--bs-btn-close-hover-opacity: .75;--bs-btn-close-focus-shadow: 0 0 0 .25rem rgba(13,110,253,0.25);--bs-btn-close-focus-opacity: 1;--bs-btn-close-disabled-opacity: .25;--bs-btn-close-white-filter: invert(1) grayscale(100%) brightness(200%);box-sizing:content-box;width:1em;height:1em;padding:.25em .25em;color:var(--bs-btn-close-color);background:transparent var(--bs-btn-close-bg) center/1em auto 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1090;position:absolute;z-index:var(--bs-toast-zindex);width:max-content;width:-webkit-max-content;width:-moz-max-content;width:-ms-max-content;width:-o-max-content;max-width:100%;pointer-events:none}.toast-container>:not(:last-child){margin-bottom:var(--bs-toast-spacing)}.toast-header{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;padding:var(--bs-toast-padding-y) var(--bs-toast-padding-x);color:var(--bs-toast-header-color);background-color:var(--bs-toast-header-bg);background-clip:padding-box;border-bottom:var(--bs-toast-border-width) solid var(--bs-toast-header-border-color);border-top-left-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width));border-top-right-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width))}.toast-header .btn-close{margin-right:calc(-.5 * var(--bs-toast-padding-x));margin-left:var(--bs-toast-padding-x)}.toast-body{padding:var(--bs-toast-padding-x);word-wrap:break-word}.modal{--bs-modal-zindex: 1055;--bs-modal-width: 500px;--bs-modal-padding: 1rem;--bs-modal-margin: .5rem;--bs-modal-color: ;--bs-modal-bg: var(--bs-body-bg);--bs-modal-border-color: var(--bs-border-color-translucent);--bs-modal-border-width: var(--bs-border-width);--bs-modal-border-radius: var(--bs-border-radius-lg);--bs-modal-box-shadow: 0 0.125rem 0.25rem rgba(0,0,0,0.075);--bs-modal-inner-border-radius: calc(var(--bs-border-radius-lg) - (var(--bs-border-width)));--bs-modal-header-padding-x: 1rem;--bs-modal-header-padding-y: 1rem;--bs-modal-header-padding: 1rem 1rem;--bs-modal-header-border-color: var(--bs-border-color);--bs-modal-header-border-width: var(--bs-border-width);--bs-modal-title-line-height: 1.5;--bs-modal-footer-gap: .5rem;--bs-modal-footer-bg: ;--bs-modal-footer-border-color: var(--bs-border-color);--bs-modal-footer-border-width: var(--bs-border-width);position:fixed;top:0;left:0;z-index:var(--bs-modal-zindex);display:none;width:100%;height:100%;overflow-x:hidden;overflow-y:auto;outline:0}.modal-dialog{position:relative;width:auto;margin:var(--bs-modal-margin);pointer-events:none}.modal.fade .modal-dialog{transition:transform 0.3s ease-out;transform:translate(0, -50px)}@media (prefers-reduced-motion: reduce){.modal.fade .modal-dialog{transition:none}}.modal.show .modal-dialog{transform:none}.modal.modal-static .modal-dialog{transform:scale(1.02)}.modal-dialog-scrollable{height:calc(100% - var(--bs-modal-margin) * 2)}.modal-dialog-scrollable .modal-content{max-height:100%;overflow:hidden}.modal-dialog-scrollable .modal-body{overflow-y:auto}.modal-dialog-centered{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;min-height:calc(100% - var(--bs-modal-margin) * 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.modal-content{height:100%;border:0;border-radius:0}.modal-fullscreen-sm-down .modal-header,.modal-fullscreen-sm-down .modal-footer{border-radius:0}.modal-fullscreen-sm-down .modal-body{overflow-y:auto}}@media (max-width: 767.98px){.modal-fullscreen-md-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-md-down .modal-content{height:100%;border:0;border-radius:0}.modal-fullscreen-md-down .modal-header,.modal-fullscreen-md-down .modal-footer{border-radius:0}.modal-fullscreen-md-down .modal-body{overflow-y:auto}}@media (max-width: 991.98px){.modal-fullscreen-lg-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-lg-down .modal-content{height:100%;border:0;border-radius:0}.modal-fullscreen-lg-down .modal-header,.modal-fullscreen-lg-down .modal-footer{border-radius:0}.modal-fullscreen-lg-down .modal-body{overflow-y:auto}}@media (max-width: 1199.98px){.modal-fullscreen-xl-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-xl-down 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diff --git a/docs/deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js b/docs/deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js
new file mode 100644
index 0000000..c628326
--- /dev/null
+++ b/docs/deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js
@@ -0,0 +1,5 @@
+/*!
+ * Bootstrap Table of Contents v1.0.1 (http://afeld.github.io/bootstrap-toc/)
+ * Copyright 2015 Aidan Feldman
+ * Licensed under MIT (https://github.com/afeld/bootstrap-toc/blob/gh-pages/LICENSE.md) */
+!function(a){"use strict";window.Toc={helpers:{findOrFilter:function(e,t){var n=e.find(t);return e.filter(t).add(n).filter(":not([data-toc-skip])")},generateUniqueIdBase:function(e){return a(e).text().trim().replace(/\'/gi,"").replace(/[& +$,:;=?@"#{}|^~[`%!'<>\]\.\/\(\)\*\\\n\t\b\v]/g,"-").replace(/-{2,}/g,"-").substring(0,64).replace(/^-+|-+$/gm,"").toLowerCase()||e.tagName.toLowerCase()},generateUniqueId:function(e){for(var t=this.generateUniqueIdBase(e),n=0;;n++){var r=t;if(0<n&&(r+="-"+n),!document.getElementById(r))return r}},generateAnchor:function(e){if(e.id)return e.id;var t=this.generateUniqueId(e);return e.id=t},createNavList:function(){return a('<ul class="nav navbar-nav"></ul>')},createChildNavList:function(e){var t=this.createNavList();return e.append(t),t},generateNavEl:function(e,t){var n=a('<a class="nav-link"></a>');n.attr("href","#"+e),n.text(t);var r=a("<li></li>");return r.append(n),r},generateNavItem:function(e){var t=this.generateAnchor(e),n=a(e),r=n.data("toc-text")||n.text();return this.generateNavEl(t,r)},getTopLevel:function(e){for(var t=1;t<=6;t++){if(1<this.findOrFilter(e,"h"+t).length)return t}return 1},getHeadings:function(e,t){var n="h"+t,r="h"+(t+1);return this.findOrFilter(e,n+","+r)},getNavLevel:function(e){return parseInt(e.tagName.charAt(1),10)},populateNav:function(r,a,e){var i,s=r,c=this;e.each(function(e,t){var n=c.generateNavItem(t);c.getNavLevel(t)===a?s=r:i&&s===r&&(s=c.createChildNavList(i)),s.append(n),i=n})},parseOps:function(e){var t;return(t=e.jquery?{$nav:e}:e).$scope=t.$scope||a(document.body),t}},init:function(e){(e=this.helpers.parseOps(e)).$nav.attr("data-toggle","toc");var t=this.helpers.createChildNavList(e.$nav),n=this.helpers.getTopLevel(e.$scope),r=this.helpers.getHeadings(e.$scope,n);this.helpers.populateNav(t,n,r)}},a(function(){a('nav[data-toggle="toc"]').each(function(e,t){var n=a(t);Toc.init(n)})})}(jQuery);
\ No newline at end of file
diff --git a/docs/deps/clipboard.js-2.0.11/clipboard.min.js b/docs/deps/clipboard.js-2.0.11/clipboard.min.js
new file mode 100644
index 0000000..1103f81
--- /dev/null
+++ b/docs/deps/clipboard.js-2.0.11/clipboard.min.js
@@ -0,0 +1,7 @@
+/*!
+ * clipboard.js v2.0.11
+ * https://clipboardjs.com/
+ *
+ * Licensed MIT © Zeno Rocha
+ */
+!function(t,e){"object"==typeof exports&&"object"==typeof module?module.exports=e():"function"==typeof define&&define.amd?define([],e):"object"==typeof exports?exports.ClipboardJS=e():t.ClipboardJS=e()}(this,function(){return n={686:function(t,e,n){"use strict";n.d(e,{default:function(){return b}});var e=n(279),i=n.n(e),e=n(370),u=n.n(e),e=n(817),r=n.n(e);function c(t){try{return document.execCommand(t)}catch(t){return}}var a=function(t){t=r()(t);return c("cut"),t};function o(t,e){var n,o,t=(n=t,o="rtl"===document.documentElement.getAttribute("dir"),(t=document.createElement("textarea")).style.fontSize="12pt",t.style.border="0",t.style.padding="0",t.style.margin="0",t.style.position="absolute",t.style[o?"right":"left"]="-9999px",o=window.pageYOffset||document.documentElement.scrollTop,t.style.top="".concat(o,"px"),t.setAttribute("readonly",""),t.value=n,t);return e.container.appendChild(t),e=r()(t),c("copy"),t.remove(),e}var f=function(t){var e=1<arguments.length&&void 0!==arguments[1]?arguments[1]:{container:document.body},n="";return"string"==typeof t?n=o(t,e):t instanceof HTMLInputElement&&!["text","search","url","tel","password"].includes(null==t?void 0:t.type)?n=o(t.value,e):(n=r()(t),c("copy")),n};function l(t){return(l="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?"symbol":typeof t})(t)}var s=function(){var t=0<arguments.length&&void 0!==arguments[0]?arguments[0]:{},e=t.action,n=void 0===e?"copy":e,o=t.container,e=t.target,t=t.text;if("copy"!==n&&"cut"!==n)throw new Error('Invalid "action" value, use either "copy" or "cut"');if(void 0!==e){if(!e||"object"!==l(e)||1!==e.nodeType)throw new Error('Invalid "target" value, use a valid Element');if("copy"===n&&e.hasAttribute("disabled"))throw new Error('Invalid "target" attribute. 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\ No newline at end of file
diff --git a/docs/deps/data-deps.txt b/docs/deps/data-deps.txt
index b905293..e0fc638 100644
--- a/docs/deps/data-deps.txt
+++ b/docs/deps/data-deps.txt
@@ -1,6 +1,15 @@
 <script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script>
 <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no" />
-<link href="deps/bootstrap-5.2.2/bootstrap.min.css" rel="stylesheet" />
-<script src="deps/bootstrap-5.2.2/bootstrap.bundle.min.js"></script>
-<link href="deps/Roboto-0.4.6/font.css" rel="stylesheet" />
-<link href="deps/Courier_Prime-0.4.6/font.css" rel="stylesheet" />
+<link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet" />
+<script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script>
+<link href="deps/Roboto-0.4.9/font.css" rel="stylesheet" />
+<link href="deps/Courier_Prime-0.4.9/font.css" rel="stylesheet" />
+<link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet" />
+<link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet" />
+<script src="deps/headroom-0.11.0/headroom.min.js"></script>
+<script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script>
+<script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script>
+<script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script>
+<script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script>
+<script src="deps/search-1.0.0/fuse.min.js"></script>
+<script src="deps/search-1.0.0/mark.min.js"></script>
diff --git a/docs/deps/font-awesome-6.4.2/css/all.css b/docs/deps/font-awesome-6.4.2/css/all.css
new file mode 100644
index 0000000..bdb6e3a
--- /dev/null
+++ b/docs/deps/font-awesome-6.4.2/css/all.css
@@ -0,0 +1,7968 @@
+/*!
+ * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2023 Fonticons, Inc.
+ */
+.fa {
+  font-family: var(--fa-style-family, "Font Awesome 6 Free");
+  font-weight: var(--fa-style, 900); }
+
+.fa,
+.fa-classic,
+.fa-sharp,
+.fas,
+.fa-solid,
+.far,
+.fa-regular,
+.fab,
+.fa-brands {
+  -moz-osx-font-smoothing: grayscale;
+  -webkit-font-smoothing: antialiased;
+  display: var(--fa-display, inline-block);
+  font-style: normal;
+  font-variant: normal;
+  line-height: 1;
+  text-rendering: auto; }
+
+.fas,
+.fa-classic,
+.fa-solid,
+.far,
+.fa-regular {
+  font-family: 'Font Awesome 6 Free'; }
+
+.fab,
+.fa-brands {
+  font-family: 'Font Awesome 6 Brands'; }
+
+.fa-1x {
+  font-size: 1em; }
+
+.fa-2x {
+  font-size: 2em; }
+
+.fa-3x {
+  font-size: 3em; }
+
+.fa-4x {
+  font-size: 4em; }
+
+.fa-5x {
+  font-size: 5em; }
+
+.fa-6x {
+  font-size: 6em; }
+
+.fa-7x {
+  font-size: 7em; }
+
+.fa-8x {
+  font-size: 8em; }
+
+.fa-9x {
+  font-size: 9em; }
+
+.fa-10x {
+  font-size: 10em; }
+
+.fa-2xs {
+  font-size: 0.625em;
+  line-height: 0.1em;
+  vertical-align: 0.225em; }
+
+.fa-xs {
+  font-size: 0.75em;
+  line-height: 0.08333em;
+  vertical-align: 0.125em; }
+
+.fa-sm {
+  font-size: 0.875em;
+  line-height: 0.07143em;
+  vertical-align: 0.05357em; }
+
+.fa-lg {
+  font-size: 1.25em;
+  line-height: 0.05em;
+  vertical-align: -0.075em; }
+
+.fa-xl {
+  font-size: 1.5em;
+  line-height: 0.04167em;
+  vertical-align: -0.125em; }
+
+.fa-2xl {
+  font-size: 2em;
+  line-height: 0.03125em;
+  vertical-align: -0.1875em; }
+
+.fa-fw {
+  text-align: center;
+  width: 1.25em; }
+
+.fa-ul {
+  list-style-type: none;
+  margin-left: var(--fa-li-margin, 2.5em);
+  padding-left: 0; }
+  .fa-ul > li {
+    position: relative; }
+
+.fa-li {
+  left: calc(var(--fa-li-width, 2em) * -1);
+  position: absolute;
+  text-align: center;
+  width: var(--fa-li-width, 2em);
+  line-height: inherit; }
+
+.fa-border {
+  border-color: var(--fa-border-color, #eee);
+  border-radius: var(--fa-border-radius, 0.1em);
+  border-style: var(--fa-border-style, solid);
+  border-width: var(--fa-border-width, 0.08em);
+  padding: var(--fa-border-padding, 0.2em 0.25em 0.15em); }
+
+.fa-pull-left {
+  float: left;
+  margin-right: var(--fa-pull-margin, 0.3em); }
+
+.fa-pull-right {
+  float: right;
+  margin-left: var(--fa-pull-margin, 0.3em); }
+
+.fa-beat {
+  -webkit-animation-name: fa-beat;
+          animation-name: fa-beat;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out);
+          animation-timing-function: var(--fa-animation-timing, ease-in-out); }
+
+.fa-bounce {
+  -webkit-animation-name: fa-bounce;
+          animation-name: fa-bounce;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1));
+          animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1)); }
+
+.fa-fade {
+  -webkit-animation-name: fa-fade;
+          animation-name: fa-fade;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1));
+          animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); }
+
+.fa-beat-fade {
+  -webkit-animation-name: fa-beat-fade;
+          animation-name: fa-beat-fade;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1));
+          animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); }
+
+.fa-flip {
+  -webkit-animation-name: fa-flip;
+          animation-name: fa-flip;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out);
+          animation-timing-function: var(--fa-animation-timing, ease-in-out); }
+
+.fa-shake {
+  -webkit-animation-name: fa-shake;
+          animation-name: fa-shake;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, linear);
+          animation-timing-function: var(--fa-animation-timing, linear); }
+
+.fa-spin {
+  -webkit-animation-name: fa-spin;
+          animation-name: fa-spin;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 2s);
+          animation-duration: var(--fa-animation-duration, 2s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, linear);
+          animation-timing-function: var(--fa-animation-timing, linear); }
+
+.fa-spin-reverse {
+  --fa-animation-direction: reverse; }
+
+.fa-pulse,
+.fa-spin-pulse {
+  -webkit-animation-name: fa-spin;
+          animation-name: fa-spin;
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, steps(8));
+          animation-timing-function: var(--fa-animation-timing, steps(8)); }
+
+@media (prefers-reduced-motion: reduce) {
+  .fa-beat,
+  .fa-bounce,
+  .fa-fade,
+  .fa-beat-fade,
+  .fa-flip,
+  .fa-pulse,
+  .fa-shake,
+  .fa-spin,
+  .fa-spin-pulse {
+    -webkit-animation-delay: -1ms;
+            animation-delay: -1ms;
+    -webkit-animation-duration: 1ms;
+            animation-duration: 1ms;
+    -webkit-animation-iteration-count: 1;
+            animation-iteration-count: 1;
+    -webkit-transition-delay: 0s;
+            transition-delay: 0s;
+    -webkit-transition-duration: 0s;
+            transition-duration: 0s; } }
+
+@-webkit-keyframes fa-beat {
+  0%, 90% {
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  45% {
+    -webkit-transform: scale(var(--fa-beat-scale, 1.25));
+            transform: scale(var(--fa-beat-scale, 1.25)); } }
+
+@keyframes fa-beat {
+  0%, 90% {
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  45% {
+    -webkit-transform: scale(var(--fa-beat-scale, 1.25));
+            transform: scale(var(--fa-beat-scale, 1.25)); } }
+
+@-webkit-keyframes fa-bounce {
+  0% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  10% {
+    -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0);
+            transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); }
+  30% {
+    -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em));
+            transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); }
+  50% {
+    -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0);
+            transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); }
+  57% {
+    -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em));
+            transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); }
+  64% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  100% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); } }
+
+@keyframes fa-bounce {
+  0% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  10% {
+    -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0);
+            transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); }
+  30% {
+    -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em));
+            transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); }
+  50% {
+    -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0);
+            transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); }
+  57% {
+    -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em));
+            transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); }
+  64% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  100% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); } }
+
+@-webkit-keyframes fa-fade {
+  50% {
+    opacity: var(--fa-fade-opacity, 0.4); } }
+
+@keyframes fa-fade {
+  50% {
+    opacity: var(--fa-fade-opacity, 0.4); } }
+
+@-webkit-keyframes fa-beat-fade {
+  0%, 100% {
+    opacity: var(--fa-beat-fade-opacity, 0.4);
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  50% {
+    opacity: 1;
+    -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125));
+            transform: scale(var(--fa-beat-fade-scale, 1.125)); } }
+
+@keyframes fa-beat-fade {
+  0%, 100% {
+    opacity: var(--fa-beat-fade-opacity, 0.4);
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  50% {
+    opacity: 1;
+    -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125));
+            transform: scale(var(--fa-beat-fade-scale, 1.125)); } }
+
+@-webkit-keyframes fa-flip {
+  50% {
+    -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg));
+            transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } }
+
+@keyframes fa-flip {
+  50% {
+    -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg));
+            transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } }
+
+@-webkit-keyframes fa-shake {
+  0% {
+    -webkit-transform: rotate(-15deg);
+            transform: rotate(-15deg); }
+  4% {
+    -webkit-transform: rotate(15deg);
+            transform: rotate(15deg); }
+  8%, 24% {
+    -webkit-transform: rotate(-18deg);
+            transform: rotate(-18deg); }
+  12%, 28% {
+    -webkit-transform: rotate(18deg);
+            transform: rotate(18deg); }
+  16% {
+    -webkit-transform: rotate(-22deg);
+            transform: rotate(-22deg); }
+  20% {
+    -webkit-transform: rotate(22deg);
+            transform: rotate(22deg); }
+  32% {
+    -webkit-transform: rotate(-12deg);
+            transform: rotate(-12deg); }
+  36% {
+    -webkit-transform: rotate(12deg);
+            transform: rotate(12deg); }
+  40%, 100% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); } }
+
+@keyframes fa-shake {
+  0% {
+    -webkit-transform: rotate(-15deg);
+            transform: rotate(-15deg); }
+  4% {
+    -webkit-transform: rotate(15deg);
+            transform: rotate(15deg); }
+  8%, 24% {
+    -webkit-transform: rotate(-18deg);
+            transform: rotate(-18deg); }
+  12%, 28% {
+    -webkit-transform: rotate(18deg);
+            transform: rotate(18deg); }
+  16% {
+    -webkit-transform: rotate(-22deg);
+            transform: rotate(-22deg); }
+  20% {
+    -webkit-transform: rotate(22deg);
+            transform: rotate(22deg); }
+  32% {
+    -webkit-transform: rotate(-12deg);
+            transform: rotate(-12deg); }
+  36% {
+    -webkit-transform: rotate(12deg);
+            transform: rotate(12deg); }
+  40%, 100% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); } }
+
+@-webkit-keyframes fa-spin {
+  0% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); }
+  100% {
+    -webkit-transform: rotate(360deg);
+            transform: rotate(360deg); } }
+
+@keyframes fa-spin {
+  0% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); }
+  100% {
+    -webkit-transform: rotate(360deg);
+            transform: rotate(360deg); } }
+
+.fa-rotate-90 {
+  -webkit-transform: rotate(90deg);
+          transform: rotate(90deg); }
+
+.fa-rotate-180 {
+  -webkit-transform: rotate(180deg);
+          transform: rotate(180deg); }
+
+.fa-rotate-270 {
+  -webkit-transform: rotate(270deg);
+          transform: rotate(270deg); }
+
+.fa-flip-horizontal {
+  -webkit-transform: scale(-1, 1);
+          transform: scale(-1, 1); }
+
+.fa-flip-vertical {
+  -webkit-transform: scale(1, -1);
+          transform: scale(1, -1); }
+
+.fa-flip-both,
+.fa-flip-horizontal.fa-flip-vertical {
+  -webkit-transform: scale(-1, -1);
+          transform: scale(-1, -1); }
+
+.fa-rotate-by {
+  -webkit-transform: rotate(var(--fa-rotate-angle, none));
+          transform: rotate(var(--fa-rotate-angle, none)); }
+
+.fa-stack {
+  display: inline-block;
+  height: 2em;
+  line-height: 2em;
+  position: relative;
+  vertical-align: middle;
+  width: 2.5em; }
+
+.fa-stack-1x,
+.fa-stack-2x {
+  left: 0;
+  position: absolute;
+  text-align: center;
+  width: 100%;
+  z-index: var(--fa-stack-z-index, auto); }
+
+.fa-stack-1x {
+  line-height: inherit; }
+
+.fa-stack-2x {
+  font-size: 2em; }
+
+.fa-inverse {
+  color: var(--fa-inverse, #fff); }
+
+/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen
+readers do not read off random characters that represent icons */
+
+.fa-0::before {
+  content: "\30"; }
+
+.fa-1::before {
+  content: "\31"; }
+
+.fa-2::before {
+  content: "\32"; }
+
+.fa-3::before {
+  content: "\33"; }
+
+.fa-4::before {
+  content: "\34"; }
+
+.fa-5::before {
+  content: "\35"; }
+
+.fa-6::before {
+  content: "\36"; }
+
+.fa-7::before {
+  content: "\37"; }
+
+.fa-8::before {
+  content: "\38"; }
+
+.fa-9::before {
+  content: "\39"; }
+
+.fa-fill-drip::before {
+  content: "\f576"; }
+
+.fa-arrows-to-circle::before {
+  content: "\e4bd"; }
+
+.fa-circle-chevron-right::before {
+  content: "\f138"; }
+
+.fa-chevron-circle-right::before {
+  content: "\f138"; }
+
+.fa-at::before {
+  content: "\40"; }
+
+.fa-trash-can::before {
+  content: "\f2ed"; }
+
+.fa-trash-alt::before {
+  content: "\f2ed"; }
+
+.fa-text-height::before {
+  content: "\f034"; }
+
+.fa-user-xmark::before {
+  content: "\f235"; }
+
+.fa-user-times::before {
+  content: "\f235"; }
+
+.fa-stethoscope::before {
+  content: "\f0f1"; }
+
+.fa-message::before {
+  content: "\f27a"; }
+
+.fa-comment-alt::before {
+  content: "\f27a"; }
+
+.fa-info::before {
+  content: "\f129"; }
+
+.fa-down-left-and-up-right-to-center::before {
+  content: "\f422"; }
+
+.fa-compress-alt::before {
+  content: "\f422"; }
+
+.fa-explosion::before {
+  content: "\e4e9"; }
+
+.fa-file-lines::before {
+  content: "\f15c"; }
+
+.fa-file-alt::before {
+  content: "\f15c"; }
+
+.fa-file-text::before {
+  content: "\f15c"; }
+
+.fa-wave-square::before {
+  content: "\f83e"; }
+
+.fa-ring::before {
+  content: "\f70b"; }
+
+.fa-building-un::before {
+  content: "\e4d9"; }
+
+.fa-dice-three::before {
+  content: "\f527"; }
+
+.fa-calendar-days::before {
+  content: "\f073"; }
+
+.fa-calendar-alt::before {
+  content: "\f073"; }
+
+.fa-anchor-circle-check::before {
+  content: "\e4aa"; }
+
+.fa-building-circle-arrow-right::before {
+  content: "\e4d1"; }
+
+.fa-volleyball::before {
+  content: "\f45f"; }
+
+.fa-volleyball-ball::before {
+  content: "\f45f"; }
+
+.fa-arrows-up-to-line::before {
+  content: "\e4c2"; }
+
+.fa-sort-down::before {
+  content: "\f0dd"; }
+
+.fa-sort-desc::before {
+  content: "\f0dd"; }
+
+.fa-circle-minus::before {
+  content: "\f056"; }
+
+.fa-minus-circle::before {
+  content: "\f056"; }
+
+.fa-door-open::before {
+  content: "\f52b"; }
+
+.fa-right-from-bracket::before {
+  content: "\f2f5"; }
+
+.fa-sign-out-alt::before {
+  content: "\f2f5"; }
+
+.fa-atom::before {
+  content: "\f5d2"; }
+
+.fa-soap::before {
+  content: "\e06e"; }
+
+.fa-icons::before {
+  content: "\f86d"; }
+
+.fa-heart-music-camera-bolt::before {
+  content: "\f86d"; }
+
+.fa-microphone-lines-slash::before {
+  content: "\f539"; }
+
+.fa-microphone-alt-slash::before {
+  content: "\f539"; }
+
+.fa-bridge-circle-check::before {
+  content: "\e4c9"; }
+
+.fa-pump-medical::before {
+  content: "\e06a"; }
+
+.fa-fingerprint::before {
+  content: "\f577"; }
+
+.fa-hand-point-right::before {
+  content: "\f0a4"; }
+
+.fa-magnifying-glass-location::before {
+  content: "\f689"; }
+
+.fa-search-location::before {
+  content: "\f689"; }
+
+.fa-forward-step::before {
+  content: "\f051"; }
+
+.fa-step-forward::before {
+  content: "\f051"; }
+
+.fa-face-smile-beam::before {
+  content: "\f5b8"; }
+
+.fa-smile-beam::before {
+  content: "\f5b8"; }
+
+.fa-flag-checkered::before {
+  content: "\f11e"; }
+
+.fa-football::before {
+  content: "\f44e"; }
+
+.fa-football-ball::before {
+  content: "\f44e"; }
+
+.fa-school-circle-exclamation::before {
+  content: "\e56c"; }
+
+.fa-crop::before {
+  content: "\f125"; }
+
+.fa-angles-down::before {
+  content: "\f103"; }
+
+.fa-angle-double-down::before {
+  content: "\f103"; }
+
+.fa-users-rectangle::before {
+  content: "\e594"; }
+
+.fa-people-roof::before {
+  content: "\e537"; }
+
+.fa-people-line::before {
+  content: "\e534"; }
+
+.fa-beer-mug-empty::before {
+  content: "\f0fc"; }
+
+.fa-beer::before {
+  content: "\f0fc"; }
+
+.fa-diagram-predecessor::before {
+  content: "\e477"; }
+
+.fa-arrow-up-long::before {
+  content: "\f176"; }
+
+.fa-long-arrow-up::before {
+  content: "\f176"; }
+
+.fa-fire-flame-simple::before {
+  content: "\f46a"; }
+
+.fa-burn::before {
+  content: "\f46a"; }
+
+.fa-person::before {
+  content: "\f183"; }
+
+.fa-male::before {
+  content: "\f183"; }
+
+.fa-laptop::before {
+  content: "\f109"; }
+
+.fa-file-csv::before {
+  content: "\f6dd"; }
+
+.fa-menorah::before {
+  content: "\f676"; }
+
+.fa-truck-plane::before {
+  content: "\e58f"; }
+
+.fa-record-vinyl::before {
+  content: "\f8d9"; }
+
+.fa-face-grin-stars::before {
+  content: "\f587"; }
+
+.fa-grin-stars::before {
+  content: "\f587"; }
+
+.fa-bong::before {
+  content: "\f55c"; }
+
+.fa-spaghetti-monster-flying::before {
+  content: "\f67b"; }
+
+.fa-pastafarianism::before {
+  content: "\f67b"; }
+
+.fa-arrow-down-up-across-line::before {
+  content: "\e4af"; }
+
+.fa-spoon::before {
+  content: "\f2e5"; }
+
+.fa-utensil-spoon::before {
+  content: "\f2e5"; }
+
+.fa-jar-wheat::before {
+  content: "\e517"; }
+
+.fa-envelopes-bulk::before {
+  content: "\f674"; }
+
+.fa-mail-bulk::before {
+  content: "\f674"; }
+
+.fa-file-circle-exclamation::before {
+  content: "\e4eb"; }
+
+.fa-circle-h::before {
+  content: "\f47e"; }
+
+.fa-hospital-symbol::before {
+  content: "\f47e"; }
+
+.fa-pager::before {
+  content: "\f815"; }
+
+.fa-address-book::before {
+  content: "\f2b9"; }
+
+.fa-contact-book::before {
+  content: "\f2b9"; }
+
+.fa-strikethrough::before {
+  content: "\f0cc"; }
+
+.fa-k::before {
+  content: "\4b"; }
+
+.fa-landmark-flag::before {
+  content: "\e51c"; }
+
+.fa-pencil::before {
+  content: "\f303"; }
+
+.fa-pencil-alt::before {
+  content: "\f303"; }
+
+.fa-backward::before {
+  content: "\f04a"; }
+
+.fa-caret-right::before {
+  content: "\f0da"; }
+
+.fa-comments::before {
+  content: "\f086"; }
+
+.fa-paste::before {
+  content: "\f0ea"; }
+
+.fa-file-clipboard::before {
+  content: "\f0ea"; }
+
+.fa-code-pull-request::before {
+  content: "\e13c"; }
+
+.fa-clipboard-list::before {
+  content: "\f46d"; }
+
+.fa-truck-ramp-box::before {
+  content: "\f4de"; }
+
+.fa-truck-loading::before {
+  content: "\f4de"; }
+
+.fa-user-check::before {
+  content: "\f4fc"; }
+
+.fa-vial-virus::before {
+  content: "\e597"; }
+
+.fa-sheet-plastic::before {
+  content: "\e571"; }
+
+.fa-blog::before {
+  content: "\f781"; }
+
+.fa-user-ninja::before {
+  content: "\f504"; }
+
+.fa-person-arrow-up-from-line::before {
+  content: "\e539"; }
+
+.fa-scroll-torah::before {
+  content: "\f6a0"; }
+
+.fa-torah::before {
+  content: "\f6a0"; }
+
+.fa-broom-ball::before {
+  content: "\f458"; }
+
+.fa-quidditch::before {
+  content: "\f458"; }
+
+.fa-quidditch-broom-ball::before {
+  content: "\f458"; }
+
+.fa-toggle-off::before {
+  content: "\f204"; }
+
+.fa-box-archive::before {
+  content: "\f187"; }
+
+.fa-archive::before {
+  content: "\f187"; }
+
+.fa-person-drowning::before {
+  content: "\e545"; }
+
+.fa-arrow-down-9-1::before {
+  content: "\f886"; }
+
+.fa-sort-numeric-desc::before {
+  content: "\f886"; }
+
+.fa-sort-numeric-down-alt::before {
+  content: "\f886"; }
+
+.fa-face-grin-tongue-squint::before {
+  content: "\f58a"; }
+
+.fa-grin-tongue-squint::before {
+  content: "\f58a"; }
+
+.fa-spray-can::before {
+  content: "\f5bd"; }
+
+.fa-truck-monster::before {
+  content: "\f63b"; }
+
+.fa-w::before {
+  content: "\57"; }
+
+.fa-earth-africa::before {
+  content: "\f57c"; }
+
+.fa-globe-africa::before {
+  content: "\f57c"; }
+
+.fa-rainbow::before {
+  content: "\f75b"; }
+
+.fa-circle-notch::before {
+  content: "\f1ce"; }
+
+.fa-tablet-screen-button::before {
+  content: "\f3fa"; }
+
+.fa-tablet-alt::before {
+  content: "\f3fa"; }
+
+.fa-paw::before {
+  content: "\f1b0"; }
+
+.fa-cloud::before {
+  content: "\f0c2"; }
+
+.fa-trowel-bricks::before {
+  content: "\e58a"; }
+
+.fa-face-flushed::before {
+  content: "\f579"; }
+
+.fa-flushed::before {
+  content: "\f579"; }
+
+.fa-hospital-user::before {
+  content: "\f80d"; }
+
+.fa-tent-arrow-left-right::before {
+  content: "\e57f"; }
+
+.fa-gavel::before {
+  content: "\f0e3"; }
+
+.fa-legal::before {
+  content: "\f0e3"; }
+
+.fa-binoculars::before {
+  content: "\f1e5"; }
+
+.fa-microphone-slash::before {
+  content: "\f131"; }
+
+.fa-box-tissue::before {
+  content: "\e05b"; }
+
+.fa-motorcycle::before {
+  content: "\f21c"; }
+
+.fa-bell-concierge::before {
+  content: "\f562"; }
+
+.fa-concierge-bell::before {
+  content: "\f562"; }
+
+.fa-pen-ruler::before {
+  content: "\f5ae"; }
+
+.fa-pencil-ruler::before {
+  content: "\f5ae"; }
+
+.fa-people-arrows::before {
+  content: "\e068"; }
+
+.fa-people-arrows-left-right::before {
+  content: "\e068"; }
+
+.fa-mars-and-venus-burst::before {
+  content: "\e523"; }
+
+.fa-square-caret-right::before {
+  content: "\f152"; }
+
+.fa-caret-square-right::before {
+  content: "\f152"; }
+
+.fa-scissors::before {
+  content: "\f0c4"; }
+
+.fa-cut::before {
+  content: "\f0c4"; }
+
+.fa-sun-plant-wilt::before {
+  content: "\e57a"; }
+
+.fa-toilets-portable::before {
+  content: "\e584"; }
+
+.fa-hockey-puck::before {
+  content: "\f453"; }
+
+.fa-table::before {
+  content: "\f0ce"; }
+
+.fa-magnifying-glass-arrow-right::before {
+  content: "\e521"; }
+
+.fa-tachograph-digital::before {
+  content: "\f566"; }
+
+.fa-digital-tachograph::before {
+  content: "\f566"; }
+
+.fa-users-slash::before {
+  content: "\e073"; }
+
+.fa-clover::before {
+  content: "\e139"; }
+
+.fa-reply::before {
+  content: "\f3e5"; }
+
+.fa-mail-reply::before {
+  content: "\f3e5"; }
+
+.fa-star-and-crescent::before {
+  content: "\f699"; }
+
+.fa-house-fire::before {
+  content: "\e50c"; }
+
+.fa-square-minus::before {
+  content: "\f146"; }
+
+.fa-minus-square::before {
+  content: "\f146"; }
+
+.fa-helicopter::before {
+  content: "\f533"; }
+
+.fa-compass::before {
+  content: "\f14e"; }
+
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+  content: "\f150"; }
+
+.fa-caret-square-down::before {
+  content: "\f150"; }
+
+.fa-file-circle-question::before {
+  content: "\e4ef"; }
+
+.fa-laptop-code::before {
+  content: "\f5fc"; }
+
+.fa-swatchbook::before {
+  content: "\f5c3"; }
+
+.fa-prescription-bottle::before {
+  content: "\f485"; }
+
+.fa-bars::before {
+  content: "\f0c9"; }
+
+.fa-navicon::before {
+  content: "\f0c9"; }
+
+.fa-people-group::before {
+  content: "\e533"; }
+
+.fa-hourglass-end::before {
+  content: "\f253"; }
+
+.fa-hourglass-3::before {
+  content: "\f253"; }
+
+.fa-heart-crack::before {
+  content: "\f7a9"; }
+
+.fa-heart-broken::before {
+  content: "\f7a9"; }
+
+.fa-square-up-right::before {
+  content: "\f360"; }
+
+.fa-external-link-square-alt::before {
+  content: "\f360"; }
+
+.fa-face-kiss-beam::before {
+  content: "\f597"; }
+
+.fa-kiss-beam::before {
+  content: "\f597"; }
+
+.fa-film::before {
+  content: "\f008"; }
+
+.fa-ruler-horizontal::before {
+  content: "\f547"; }
+
+.fa-people-robbery::before {
+  content: "\e536"; }
+
+.fa-lightbulb::before {
+  content: "\f0eb"; }
+
+.fa-caret-left::before {
+  content: "\f0d9"; }
+
+.fa-circle-exclamation::before {
+  content: "\f06a"; }
+
+.fa-exclamation-circle::before {
+  content: "\f06a"; }
+
+.fa-school-circle-xmark::before {
+  content: "\e56d"; }
+
+.fa-arrow-right-from-bracket::before {
+  content: "\f08b"; }
+
+.fa-sign-out::before {
+  content: "\f08b"; }
+
+.fa-circle-chevron-down::before {
+  content: "\f13a"; }
+
+.fa-chevron-circle-down::before {
+  content: "\f13a"; }
+
+.fa-unlock-keyhole::before {
+  content: "\f13e"; }
+
+.fa-unlock-alt::before {
+  content: "\f13e"; }
+
+.fa-cloud-showers-heavy::before {
+  content: "\f740"; }
+
+.fa-headphones-simple::before {
+  content: "\f58f"; }
+
+.fa-headphones-alt::before {
+  content: "\f58f"; }
+
+.fa-sitemap::before {
+  content: "\f0e8"; }
+
+.fa-circle-dollar-to-slot::before {
+  content: "\f4b9"; }
+
+.fa-donate::before {
+  content: "\f4b9"; }
+
+.fa-memory::before {
+  content: "\f538"; }
+
+.fa-road-spikes::before {
+  content: "\e568"; }
+
+.fa-fire-burner::before {
+  content: "\e4f1"; }
+
+.fa-flag::before {
+  content: "\f024"; }
+
+.fa-hanukiah::before {
+  content: "\f6e6"; }
+
+.fa-feather::before {
+  content: "\f52d"; }
+
+.fa-volume-low::before {
+  content: "\f027"; }
+
+.fa-volume-down::before {
+  content: "\f027"; }
+
+.fa-comment-slash::before {
+  content: "\f4b3"; }
+
+.fa-cloud-sun-rain::before {
+  content: "\f743"; }
+
+.fa-compress::before {
+  content: "\f066"; }
+
+.fa-wheat-awn::before {
+  content: "\e2cd"; }
+
+.fa-wheat-alt::before {
+  content: "\e2cd"; }
+
+.fa-ankh::before {
+  content: "\f644"; }
+
+.fa-hands-holding-child::before {
+  content: "\e4fa"; }
+
+.fa-asterisk::before {
+  content: "\2a"; }
+
+.fa-square-check::before {
+  content: "\f14a"; }
+
+.fa-check-square::before {
+  content: "\f14a"; }
+
+.fa-peseta-sign::before {
+  content: "\e221"; }
+
+.fa-heading::before {
+  content: "\f1dc"; }
+
+.fa-header::before {
+  content: "\f1dc"; }
+
+.fa-ghost::before {
+  content: "\f6e2"; }
+
+.fa-list::before {
+  content: "\f03a"; }
+
+.fa-list-squares::before {
+  content: "\f03a"; }
+
+.fa-square-phone-flip::before {
+  content: "\f87b"; }
+
+.fa-phone-square-alt::before {
+  content: "\f87b"; }
+
+.fa-cart-plus::before {
+  content: "\f217"; }
+
+.fa-gamepad::before {
+  content: "\f11b"; }
+
+.fa-circle-dot::before {
+  content: "\f192"; }
+
+.fa-dot-circle::before {
+  content: "\f192"; }
+
+.fa-face-dizzy::before {
+  content: "\f567"; }
+
+.fa-dizzy::before {
+  content: "\f567"; }
+
+.fa-egg::before {
+  content: "\f7fb"; }
+
+.fa-house-medical-circle-xmark::before {
+  content: "\e513"; }
+
+.fa-campground::before {
+  content: "\f6bb"; }
+
+.fa-folder-plus::before {
+  content: "\f65e"; }
+
+.fa-futbol::before {
+  content: "\f1e3"; }
+
+.fa-futbol-ball::before {
+  content: "\f1e3"; }
+
+.fa-soccer-ball::before {
+  content: "\f1e3"; }
+
+.fa-paintbrush::before {
+  content: "\f1fc"; }
+
+.fa-paint-brush::before {
+  content: "\f1fc"; }
+
+.fa-lock::before {
+  content: "\f023"; }
+
+.fa-gas-pump::before {
+  content: "\f52f"; }
+
+.fa-hot-tub-person::before {
+  content: "\f593"; }
+
+.fa-hot-tub::before {
+  content: "\f593"; }
+
+.fa-map-location::before {
+  content: "\f59f"; }
+
+.fa-map-marked::before {
+  content: "\f59f"; }
+
+.fa-house-flood-water::before {
+  content: "\e50e"; }
+
+.fa-tree::before {
+  content: "\f1bb"; }
+
+.fa-bridge-lock::before {
+  content: "\e4cc"; }
+
+.fa-sack-dollar::before {
+  content: "\f81d"; }
+
+.fa-pen-to-square::before {
+  content: "\f044"; }
+
+.fa-edit::before {
+  content: "\f044"; }
+
+.fa-car-side::before {
+  content: "\f5e4"; }
+
+.fa-share-nodes::before {
+  content: "\f1e0"; }
+
+.fa-share-alt::before {
+  content: "\f1e0"; }
+
+.fa-heart-circle-minus::before {
+  content: "\e4ff"; }
+
+.fa-hourglass-half::before {
+  content: "\f252"; }
+
+.fa-hourglass-2::before {
+  content: "\f252"; }
+
+.fa-microscope::before {
+  content: "\f610"; }
+
+.fa-sink::before {
+  content: "\e06d"; }
+
+.fa-bag-shopping::before {
+  content: "\f290"; }
+
+.fa-shopping-bag::before {
+  content: "\f290"; }
+
+.fa-arrow-down-z-a::before {
+  content: "\f881"; }
+
+.fa-sort-alpha-desc::before {
+  content: "\f881"; }
+
+.fa-sort-alpha-down-alt::before {
+  content: "\f881"; }
+
+.fa-mitten::before {
+  content: "\f7b5"; }
+
+.fa-person-rays::before {
+  content: "\e54d"; }
+
+.fa-users::before {
+  content: "\f0c0"; }
+
+.fa-eye-slash::before {
+  content: "\f070"; }
+
+.fa-flask-vial::before {
+  content: "\e4f3"; }
+
+.fa-hand::before {
+  content: "\f256"; }
+
+.fa-hand-paper::before {
+  content: "\f256"; }
+
+.fa-om::before {
+  content: "\f679"; }
+
+.fa-worm::before {
+  content: "\e599"; }
+
+.fa-house-circle-xmark::before {
+  content: "\e50b"; }
+
+.fa-plug::before {
+  content: "\f1e6"; }
+
+.fa-chevron-up::before {
+  content: "\f077"; }
+
+.fa-hand-spock::before {
+  content: "\f259"; }
+
+.fa-stopwatch::before {
+  content: "\f2f2"; }
+
+.fa-face-kiss::before {
+  content: "\f596"; }
+
+.fa-kiss::before {
+  content: "\f596"; }
+
+.fa-bridge-circle-xmark::before {
+  content: "\e4cb"; }
+
+.fa-face-grin-tongue::before {
+  content: "\f589"; }
+
+.fa-grin-tongue::before {
+  content: "\f589"; }
+
+.fa-chess-bishop::before {
+  content: "\f43a"; }
+
+.fa-face-grin-wink::before {
+  content: "\f58c"; }
+
+.fa-grin-wink::before {
+  content: "\f58c"; }
+
+.fa-ear-deaf::before {
+  content: "\f2a4"; }
+
+.fa-deaf::before {
+  content: "\f2a4"; }
+
+.fa-deafness::before {
+  content: "\f2a4"; }
+
+.fa-hard-of-hearing::before {
+  content: "\f2a4"; }
+
+.fa-road-circle-check::before {
+  content: "\e564"; }
+
+.fa-dice-five::before {
+  content: "\f523"; }
+
+.fa-square-rss::before {
+  content: "\f143"; }
+
+.fa-rss-square::before {
+  content: "\f143"; }
+
+.fa-land-mine-on::before {
+  content: "\e51b"; }
+
+.fa-i-cursor::before {
+  content: "\f246"; }
+
+.fa-stamp::before {
+  content: "\f5bf"; }
+
+.fa-stairs::before {
+  content: "\e289"; }
+
+.fa-i::before {
+  content: "\49"; }
+
+.fa-hryvnia-sign::before {
+  content: "\f6f2"; }
+
+.fa-hryvnia::before {
+  content: "\f6f2"; }
+
+.fa-pills::before {
+  content: "\f484"; }
+
+.fa-face-grin-wide::before {
+  content: "\f581"; }
+
+.fa-grin-alt::before {
+  content: "\f581"; }
+
+.fa-tooth::before {
+  content: "\f5c9"; }
+
+.fa-v::before {
+  content: "\56"; }
+
+.fa-bangladeshi-taka-sign::before {
+  content: "\e2e6"; }
+
+.fa-bicycle::before {
+  content: "\f206"; }
+
+.fa-staff-snake::before {
+  content: "\e579"; }
+
+.fa-rod-asclepius::before {
+  content: "\e579"; }
+
+.fa-rod-snake::before {
+  content: "\e579"; }
+
+.fa-staff-aesculapius::before {
+  content: "\e579"; }
+
+.fa-head-side-cough-slash::before {
+  content: "\e062"; }
+
+.fa-truck-medical::before {
+  content: "\f0f9"; }
+
+.fa-ambulance::before {
+  content: "\f0f9"; }
+
+.fa-wheat-awn-circle-exclamation::before {
+  content: "\e598"; }
+
+.fa-snowman::before {
+  content: "\f7d0"; }
+
+.fa-mortar-pestle::before {
+  content: "\f5a7"; }
+
+.fa-road-barrier::before {
+  content: "\e562"; }
+
+.fa-school::before {
+  content: "\f549"; }
+
+.fa-igloo::before {
+  content: "\f7ae"; }
+
+.fa-joint::before {
+  content: "\f595"; }
+
+.fa-angle-right::before {
+  content: "\f105"; }
+
+.fa-horse::before {
+  content: "\f6f0"; }
+
+.fa-q::before {
+  content: "\51"; }
+
+.fa-g::before {
+  content: "\47"; }
+
+.fa-notes-medical::before {
+  content: "\f481"; }
+
+.fa-temperature-half::before {
+  content: "\f2c9"; }
+
+.fa-temperature-2::before {
+  content: "\f2c9"; }
+
+.fa-thermometer-2::before {
+  content: "\f2c9"; }
+
+.fa-thermometer-half::before {
+  content: "\f2c9"; }
+
+.fa-dong-sign::before {
+  content: "\e169"; }
+
+.fa-capsules::before {
+  content: "\f46b"; }
+
+.fa-poo-storm::before {
+  content: "\f75a"; }
+
+.fa-poo-bolt::before {
+  content: "\f75a"; }
+
+.fa-face-frown-open::before {
+  content: "\f57a"; }
+
+.fa-frown-open::before {
+  content: "\f57a"; }
+
+.fa-hand-point-up::before {
+  content: "\f0a6"; }
+
+.fa-money-bill::before {
+  content: "\f0d6"; }
+
+.fa-bookmark::before {
+  content: "\f02e"; }
+
+.fa-align-justify::before {
+  content: "\f039"; }
+
+.fa-umbrella-beach::before {
+  content: "\f5ca"; }
+
+.fa-helmet-un::before {
+  content: "\e503"; }
+
+.fa-bullseye::before {
+  content: "\f140"; }
+
+.fa-bacon::before {
+  content: "\f7e5"; }
+
+.fa-hand-point-down::before {
+  content: "\f0a7"; }
+
+.fa-arrow-up-from-bracket::before {
+  content: "\e09a"; }
+
+.fa-folder::before {
+  content: "\f07b"; }
+
+.fa-folder-blank::before {
+  content: "\f07b"; }
+
+.fa-file-waveform::before {
+  content: "\f478"; }
+
+.fa-file-medical-alt::before {
+  content: "\f478"; }
+
+.fa-radiation::before {
+  content: "\f7b9"; }
+
+.fa-chart-simple::before {
+  content: "\e473"; }
+
+.fa-mars-stroke::before {
+  content: "\f229"; }
+
+.fa-vial::before {
+  content: "\f492"; }
+
+.fa-gauge::before {
+  content: "\f624"; }
+
+.fa-dashboard::before {
+  content: "\f624"; }
+
+.fa-gauge-med::before {
+  content: "\f624"; }
+
+.fa-tachometer-alt-average::before {
+  content: "\f624"; }
+
+.fa-wand-magic-sparkles::before {
+  content: "\e2ca"; }
+
+.fa-magic-wand-sparkles::before {
+  content: "\e2ca"; }
+
+.fa-e::before {
+  content: "\45"; }
+
+.fa-pen-clip::before {
+  content: "\f305"; }
+
+.fa-pen-alt::before {
+  content: "\f305"; }
+
+.fa-bridge-circle-exclamation::before {
+  content: "\e4ca"; }
+
+.fa-user::before {
+  content: "\f007"; }
+
+.fa-school-circle-check::before {
+  content: "\e56b"; }
+
+.fa-dumpster::before {
+  content: "\f793"; }
+
+.fa-van-shuttle::before {
+  content: "\f5b6"; }
+
+.fa-shuttle-van::before {
+  content: "\f5b6"; }
+
+.fa-building-user::before {
+  content: "\e4da"; }
+
+.fa-square-caret-left::before {
+  content: "\f191"; }
+
+.fa-caret-square-left::before {
+  content: "\f191"; }
+
+.fa-highlighter::before {
+  content: "\f591"; }
+
+.fa-key::before {
+  content: "\f084"; }
+
+.fa-bullhorn::before {
+  content: "\f0a1"; }
+
+.fa-globe::before {
+  content: "\f0ac"; }
+
+.fa-synagogue::before {
+  content: "\f69b"; }
+
+.fa-person-half-dress::before {
+  content: "\e548"; }
+
+.fa-road-bridge::before {
+  content: "\e563"; }
+
+.fa-location-arrow::before {
+  content: "\f124"; }
+
+.fa-c::before {
+  content: "\43"; }
+
+.fa-tablet-button::before {
+  content: "\f10a"; }
+
+.fa-building-lock::before {
+  content: "\e4d6"; }
+
+.fa-pizza-slice::before {
+  content: "\f818"; }
+
+.fa-money-bill-wave::before {
+  content: "\f53a"; }
+
+.fa-chart-area::before {
+  content: "\f1fe"; }
+
+.fa-area-chart::before {
+  content: "\f1fe"; }
+
+.fa-house-flag::before {
+  content: "\e50d"; }
+
+.fa-person-circle-minus::before {
+  content: "\e540"; }
+
+.fa-ban::before {
+  content: "\f05e"; }
+
+.fa-cancel::before {
+  content: "\f05e"; }
+
+.fa-camera-rotate::before {
+  content: "\e0d8"; }
+
+.fa-spray-can-sparkles::before {
+  content: "\f5d0"; }
+
+.fa-air-freshener::before {
+  content: "\f5d0"; }
+
+.fa-star::before {
+  content: "\f005"; }
+
+.fa-repeat::before {
+  content: "\f363"; }
+
+.fa-cross::before {
+  content: "\f654"; }
+
+.fa-box::before {
+  content: "\f466"; }
+
+.fa-venus-mars::before {
+  content: "\f228"; }
+
+.fa-arrow-pointer::before {
+  content: "\f245"; }
+
+.fa-mouse-pointer::before {
+  content: "\f245"; }
+
+.fa-maximize::before {
+  content: "\f31e"; }
+
+.fa-expand-arrows-alt::before {
+  content: "\f31e"; }
+
+.fa-charging-station::before {
+  content: "\f5e7"; }
+
+.fa-shapes::before {
+  content: "\f61f"; }
+
+.fa-triangle-circle-square::before {
+  content: "\f61f"; }
+
+.fa-shuffle::before {
+  content: "\f074"; }
+
+.fa-random::before {
+  content: "\f074"; }
+
+.fa-person-running::before {
+  content: "\f70c"; }
+
+.fa-running::before {
+  content: "\f70c"; }
+
+.fa-mobile-retro::before {
+  content: "\e527"; }
+
+.fa-grip-lines-vertical::before {
+  content: "\f7a5"; }
+
+.fa-spider::before {
+  content: "\f717"; }
+
+.fa-hands-bound::before {
+  content: "\e4f9"; }
+
+.fa-file-invoice-dollar::before {
+  content: "\f571"; }
+
+.fa-plane-circle-exclamation::before {
+  content: "\e556"; }
+
+.fa-x-ray::before {
+  content: "\f497"; }
+
+.fa-spell-check::before {
+  content: "\f891"; }
+
+.fa-slash::before {
+  content: "\f715"; }
+
+.fa-computer-mouse::before {
+  content: "\f8cc"; }
+
+.fa-mouse::before {
+  content: "\f8cc"; }
+
+.fa-arrow-right-to-bracket::before {
+  content: "\f090"; }
+
+.fa-sign-in::before {
+  content: "\f090"; }
+
+.fa-shop-slash::before {
+  content: "\e070"; }
+
+.fa-store-alt-slash::before {
+  content: "\e070"; }
+
+.fa-server::before {
+  content: "\f233"; }
+
+.fa-virus-covid-slash::before {
+  content: "\e4a9"; }
+
+.fa-shop-lock::before {
+  content: "\e4a5"; }
+
+.fa-hourglass-start::before {
+  content: "\f251"; }
+
+.fa-hourglass-1::before {
+  content: "\f251"; }
+
+.fa-blender-phone::before {
+  content: "\f6b6"; }
+
+.fa-building-wheat::before {
+  content: "\e4db"; }
+
+.fa-person-breastfeeding::before {
+  content: "\e53a"; }
+
+.fa-right-to-bracket::before {
+  content: "\f2f6"; }
+
+.fa-sign-in-alt::before {
+  content: "\f2f6"; }
+
+.fa-venus::before {
+  content: "\f221"; }
+
+.fa-passport::before {
+  content: "\f5ab"; }
+
+.fa-heart-pulse::before {
+  content: "\f21e"; }
+
+.fa-heartbeat::before {
+  content: "\f21e"; }
+
+.fa-people-carry-box::before {
+  content: "\f4ce"; }
+
+.fa-people-carry::before {
+  content: "\f4ce"; }
+
+.fa-temperature-high::before {
+  content: "\f769"; }
+
+.fa-microchip::before {
+  content: "\f2db"; }
+
+.fa-crown::before {
+  content: "\f521"; }
+
+.fa-weight-hanging::before {
+  content: "\f5cd"; }
+
+.fa-xmarks-lines::before {
+  content: "\e59a"; }
+
+.fa-file-prescription::before {
+  content: "\f572"; }
+
+.fa-weight-scale::before {
+  content: "\f496"; }
+
+.fa-weight::before {
+  content: "\f496"; }
+
+.fa-user-group::before {
+  content: "\f500"; }
+
+.fa-user-friends::before {
+  content: "\f500"; }
+
+.fa-arrow-up-a-z::before {
+  content: "\f15e"; }
+
+.fa-sort-alpha-up::before {
+  content: "\f15e"; }
+
+.fa-chess-knight::before {
+  content: "\f441"; }
+
+.fa-face-laugh-squint::before {
+  content: "\f59b"; }
+
+.fa-laugh-squint::before {
+  content: "\f59b"; }
+
+.fa-wheelchair::before {
+  content: "\f193"; }
+
+.fa-circle-arrow-up::before {
+  content: "\f0aa"; }
+
+.fa-arrow-circle-up::before {
+  content: "\f0aa"; }
+
+.fa-toggle-on::before {
+  content: "\f205"; }
+
+.fa-person-walking::before {
+  content: "\f554"; }
+
+.fa-walking::before {
+  content: "\f554"; }
+
+.fa-l::before {
+  content: "\4c"; }
+
+.fa-fire::before {
+  content: "\f06d"; }
+
+.fa-bed-pulse::before {
+  content: "\f487"; }
+
+.fa-procedures::before {
+  content: "\f487"; }
+
+.fa-shuttle-space::before {
+  content: "\f197"; }
+
+.fa-space-shuttle::before {
+  content: "\f197"; }
+
+.fa-face-laugh::before {
+  content: "\f599"; }
+
+.fa-laugh::before {
+  content: "\f599"; }
+
+.fa-folder-open::before {
+  content: "\f07c"; }
+
+.fa-heart-circle-plus::before {
+  content: "\e500"; }
+
+.fa-code-fork::before {
+  content: "\e13b"; }
+
+.fa-city::before {
+  content: "\f64f"; }
+
+.fa-microphone-lines::before {
+  content: "\f3c9"; }
+
+.fa-microphone-alt::before {
+  content: "\f3c9"; }
+
+.fa-pepper-hot::before {
+  content: "\f816"; }
+
+.fa-unlock::before {
+  content: "\f09c"; }
+
+.fa-colon-sign::before {
+  content: "\e140"; }
+
+.fa-headset::before {
+  content: "\f590"; }
+
+.fa-store-slash::before {
+  content: "\e071"; }
+
+.fa-road-circle-xmark::before {
+  content: "\e566"; }
+
+.fa-user-minus::before {
+  content: "\f503"; }
+
+.fa-mars-stroke-up::before {
+  content: "\f22a"; }
+
+.fa-mars-stroke-v::before {
+  content: "\f22a"; }
+
+.fa-champagne-glasses::before {
+  content: "\f79f"; }
+
+.fa-glass-cheers::before {
+  content: "\f79f"; }
+
+.fa-clipboard::before {
+  content: "\f328"; }
+
+.fa-house-circle-exclamation::before {
+  content: "\e50a"; }
+
+.fa-file-arrow-up::before {
+  content: "\f574"; }
+
+.fa-file-upload::before {
+  content: "\f574"; }
+
+.fa-wifi::before {
+  content: "\f1eb"; }
+
+.fa-wifi-3::before {
+  content: "\f1eb"; }
+
+.fa-wifi-strong::before {
+  content: "\f1eb"; }
+
+.fa-bath::before {
+  content: "\f2cd"; }
+
+.fa-bathtub::before {
+  content: "\f2cd"; }
+
+.fa-underline::before {
+  content: "\f0cd"; }
+
+.fa-user-pen::before {
+  content: "\f4ff"; }
+
+.fa-user-edit::before {
+  content: "\f4ff"; }
+
+.fa-signature::before {
+  content: "\f5b7"; }
+
+.fa-stroopwafel::before {
+  content: "\f551"; }
+
+.fa-bold::before {
+  content: "\f032"; }
+
+.fa-anchor-lock::before {
+  content: "\e4ad"; }
+
+.fa-building-ngo::before {
+  content: "\e4d7"; }
+
+.fa-manat-sign::before {
+  content: "\e1d5"; }
+
+.fa-not-equal::before {
+  content: "\f53e"; }
+
+.fa-border-top-left::before {
+  content: "\f853"; }
+
+.fa-border-style::before {
+  content: "\f853"; }
+
+.fa-map-location-dot::before {
+  content: "\f5a0"; }
+
+.fa-map-marked-alt::before {
+  content: "\f5a0"; }
+
+.fa-jedi::before {
+  content: "\f669"; }
+
+.fa-square-poll-vertical::before {
+  content: "\f681"; }
+
+.fa-poll::before {
+  content: "\f681"; }
+
+.fa-mug-hot::before {
+  content: "\f7b6"; }
+
+.fa-car-battery::before {
+  content: "\f5df"; }
+
+.fa-battery-car::before {
+  content: "\f5df"; }
+
+.fa-gift::before {
+  content: "\f06b"; }
+
+.fa-dice-two::before {
+  content: "\f528"; }
+
+.fa-chess-queen::before {
+  content: "\f445"; }
+
+.fa-glasses::before {
+  content: "\f530"; }
+
+.fa-chess-board::before {
+  content: "\f43c"; }
+
+.fa-building-circle-check::before {
+  content: "\e4d2"; }
+
+.fa-person-chalkboard::before {
+  content: "\e53d"; }
+
+.fa-mars-stroke-right::before {
+  content: "\f22b"; }
+
+.fa-mars-stroke-h::before {
+  content: "\f22b"; }
+
+.fa-hand-back-fist::before {
+  content: "\f255"; }
+
+.fa-hand-rock::before {
+  content: "\f255"; }
+
+.fa-square-caret-up::before {
+  content: "\f151"; }
+
+.fa-caret-square-up::before {
+  content: "\f151"; }
+
+.fa-cloud-showers-water::before {
+  content: "\e4e4"; }
+
+.fa-chart-bar::before {
+  content: "\f080"; }
+
+.fa-bar-chart::before {
+  content: "\f080"; }
+
+.fa-hands-bubbles::before {
+  content: "\e05e"; }
+
+.fa-hands-wash::before {
+  content: "\e05e"; }
+
+.fa-less-than-equal::before {
+  content: "\f537"; }
+
+.fa-train::before {
+  content: "\f238"; }
+
+.fa-eye-low-vision::before {
+  content: "\f2a8"; }
+
+.fa-low-vision::before {
+  content: "\f2a8"; }
+
+.fa-crow::before {
+  content: "\f520"; }
+
+.fa-sailboat::before {
+  content: "\e445"; }
+
+.fa-window-restore::before {
+  content: "\f2d2"; }
+
+.fa-square-plus::before {
+  content: "\f0fe"; }
+
+.fa-plus-square::before {
+  content: "\f0fe"; }
+
+.fa-torii-gate::before {
+  content: "\f6a1"; }
+
+.fa-frog::before {
+  content: "\f52e"; }
+
+.fa-bucket::before {
+  content: "\e4cf"; }
+
+.fa-image::before {
+  content: "\f03e"; }
+
+.fa-microphone::before {
+  content: "\f130"; }
+
+.fa-cow::before {
+  content: "\f6c8"; }
+
+.fa-caret-up::before {
+  content: "\f0d8"; }
+
+.fa-screwdriver::before {
+  content: "\f54a"; }
+
+.fa-folder-closed::before {
+  content: "\e185"; }
+
+.fa-house-tsunami::before {
+  content: "\e515"; }
+
+.fa-square-nfi::before {
+  content: "\e576"; }
+
+.fa-arrow-up-from-ground-water::before {
+  content: "\e4b5"; }
+
+.fa-martini-glass::before {
+  content: "\f57b"; }
+
+.fa-glass-martini-alt::before {
+  content: "\f57b"; }
+
+.fa-rotate-left::before {
+  content: "\f2ea"; }
+
+.fa-rotate-back::before {
+  content: "\f2ea"; }
+
+.fa-rotate-backward::before {
+  content: "\f2ea"; }
+
+.fa-undo-alt::before {
+  content: "\f2ea"; }
+
+.fa-table-columns::before {
+  content: "\f0db"; }
+
+.fa-columns::before {
+  content: "\f0db"; }
+
+.fa-lemon::before {
+  content: "\f094"; }
+
+.fa-head-side-mask::before {
+  content: "\e063"; }
+
+.fa-handshake::before {
+  content: "\f2b5"; }
+
+.fa-gem::before {
+  content: "\f3a5"; }
+
+.fa-dolly::before {
+  content: "\f472"; }
+
+.fa-dolly-box::before {
+  content: "\f472"; }
+
+.fa-smoking::before {
+  content: "\f48d"; }
+
+.fa-minimize::before {
+  content: "\f78c"; }
+
+.fa-compress-arrows-alt::before {
+  content: "\f78c"; }
+
+.fa-monument::before {
+  content: "\f5a6"; }
+
+.fa-snowplow::before {
+  content: "\f7d2"; }
+
+.fa-angles-right::before {
+  content: "\f101"; }
+
+.fa-angle-double-right::before {
+  content: "\f101"; }
+
+.fa-cannabis::before {
+  content: "\f55f"; }
+
+.fa-circle-play::before {
+  content: "\f144"; }
+
+.fa-play-circle::before {
+  content: "\f144"; }
+
+.fa-tablets::before {
+  content: "\f490"; }
+
+.fa-ethernet::before {
+  content: "\f796"; }
+
+.fa-euro-sign::before {
+  content: "\f153"; }
+
+.fa-eur::before {
+  content: "\f153"; }
+
+.fa-euro::before {
+  content: "\f153"; }
+
+.fa-chair::before {
+  content: "\f6c0"; }
+
+.fa-circle-check::before {
+  content: "\f058"; }
+
+.fa-check-circle::before {
+  content: "\f058"; }
+
+.fa-circle-stop::before {
+  content: "\f28d"; }
+
+.fa-stop-circle::before {
+  content: "\f28d"; }
+
+.fa-compass-drafting::before {
+  content: "\f568"; }
+
+.fa-drafting-compass::before {
+  content: "\f568"; }
+
+.fa-plate-wheat::before {
+  content: "\e55a"; }
+
+.fa-icicles::before {
+  content: "\f7ad"; }
+
+.fa-person-shelter::before {
+  content: "\e54f"; }
+
+.fa-neuter::before {
+  content: "\f22c"; }
+
+.fa-id-badge::before {
+  content: "\f2c1"; }
+
+.fa-marker::before {
+  content: "\f5a1"; }
+
+.fa-face-laugh-beam::before {
+  content: "\f59a"; }
+
+.fa-laugh-beam::before {
+  content: "\f59a"; }
+
+.fa-helicopter-symbol::before {
+  content: "\e502"; }
+
+.fa-universal-access::before {
+  content: "\f29a"; }
+
+.fa-circle-chevron-up::before {
+  content: "\f139"; }
+
+.fa-chevron-circle-up::before {
+  content: "\f139"; }
+
+.fa-lari-sign::before {
+  content: "\e1c8"; }
+
+.fa-volcano::before {
+  content: "\f770"; }
+
+.fa-person-walking-dashed-line-arrow-right::before {
+  content: "\e553"; }
+
+.fa-sterling-sign::before {
+  content: "\f154"; }
+
+.fa-gbp::before {
+  content: "\f154"; }
+
+.fa-pound-sign::before {
+  content: "\f154"; }
+
+.fa-viruses::before {
+  content: "\e076"; }
+
+.fa-square-person-confined::before {
+  content: "\e577"; }
+
+.fa-user-tie::before {
+  content: "\f508"; }
+
+.fa-arrow-down-long::before {
+  content: "\f175"; }
+
+.fa-long-arrow-down::before {
+  content: "\f175"; }
+
+.fa-tent-arrow-down-to-line::before {
+  content: "\e57e"; }
+
+.fa-certificate::before {
+  content: "\f0a3"; }
+
+.fa-reply-all::before {
+  content: "\f122"; }
+
+.fa-mail-reply-all::before {
+  content: "\f122"; }
+
+.fa-suitcase::before {
+  content: "\f0f2"; }
+
+.fa-person-skating::before {
+  content: "\f7c5"; }
+
+.fa-skating::before {
+  content: "\f7c5"; }
+
+.fa-filter-circle-dollar::before {
+  content: "\f662"; }
+
+.fa-funnel-dollar::before {
+  content: "\f662"; }
+
+.fa-camera-retro::before {
+  content: "\f083"; }
+
+.fa-circle-arrow-down::before {
+  content: "\f0ab"; }
+
+.fa-arrow-circle-down::before {
+  content: "\f0ab"; }
+
+.fa-file-import::before {
+  content: "\f56f"; }
+
+.fa-arrow-right-to-file::before {
+  content: "\f56f"; }
+
+.fa-square-arrow-up-right::before {
+  content: "\f14c"; }
+
+.fa-external-link-square::before {
+  content: "\f14c"; }
+
+.fa-box-open::before {
+  content: "\f49e"; }
+
+.fa-scroll::before {
+  content: "\f70e"; }
+
+.fa-spa::before {
+  content: "\f5bb"; }
+
+.fa-location-pin-lock::before {
+  content: "\e51f"; }
+
+.fa-pause::before {
+  content: "\f04c"; }
+
+.fa-hill-avalanche::before {
+  content: "\e507"; }
+
+.fa-temperature-empty::before {
+  content: "\f2cb"; }
+
+.fa-temperature-0::before {
+  content: "\f2cb"; }
+
+.fa-thermometer-0::before {
+  content: "\f2cb"; }
+
+.fa-thermometer-empty::before {
+  content: "\f2cb"; }
+
+.fa-bomb::before {
+  content: "\f1e2"; }
+
+.fa-registered::before {
+  content: "\f25d"; }
+
+.fa-address-card::before {
+  content: "\f2bb"; }
+
+.fa-contact-card::before {
+  content: "\f2bb"; }
+
+.fa-vcard::before {
+  content: "\f2bb"; }
+
+.fa-scale-unbalanced-flip::before {
+  content: "\f516"; }
+
+.fa-balance-scale-right::before {
+  content: "\f516"; }
+
+.fa-subscript::before {
+  content: "\f12c"; }
+
+.fa-diamond-turn-right::before {
+  content: "\f5eb"; }
+
+.fa-directions::before {
+  content: "\f5eb"; }
+
+.fa-burst::before {
+  content: "\e4dc"; }
+
+.fa-house-laptop::before {
+  content: "\e066"; }
+
+.fa-laptop-house::before {
+  content: "\e066"; }
+
+.fa-face-tired::before {
+  content: "\f5c8"; }
+
+.fa-tired::before {
+  content: "\f5c8"; }
+
+.fa-money-bills::before {
+  content: "\e1f3"; }
+
+.fa-smog::before {
+  content: "\f75f"; }
+
+.fa-crutch::before {
+  content: "\f7f7"; }
+
+.fa-cloud-arrow-up::before {
+  content: "\f0ee"; }
+
+.fa-cloud-upload::before {
+  content: "\f0ee"; }
+
+.fa-cloud-upload-alt::before {
+  content: "\f0ee"; }
+
+.fa-palette::before {
+  content: "\f53f"; }
+
+.fa-arrows-turn-right::before {
+  content: "\e4c0"; }
+
+.fa-vest::before {
+  content: "\e085"; }
+
+.fa-ferry::before {
+  content: "\e4ea"; }
+
+.fa-arrows-down-to-people::before {
+  content: "\e4b9"; }
+
+.fa-seedling::before {
+  content: "\f4d8"; }
+
+.fa-sprout::before {
+  content: "\f4d8"; }
+
+.fa-left-right::before {
+  content: "\f337"; }
+
+.fa-arrows-alt-h::before {
+  content: "\f337"; }
+
+.fa-boxes-packing::before {
+  content: "\e4c7"; }
+
+.fa-circle-arrow-left::before {
+  content: "\f0a8"; }
+
+.fa-arrow-circle-left::before {
+  content: "\f0a8"; }
+
+.fa-group-arrows-rotate::before {
+  content: "\e4f6"; }
+
+.fa-bowl-food::before {
+  content: "\e4c6"; }
+
+.fa-candy-cane::before {
+  content: "\f786"; }
+
+.fa-arrow-down-wide-short::before {
+  content: "\f160"; }
+
+.fa-sort-amount-asc::before {
+  content: "\f160"; }
+
+.fa-sort-amount-down::before {
+  content: "\f160"; }
+
+.fa-cloud-bolt::before {
+  content: "\f76c"; }
+
+.fa-thunderstorm::before {
+  content: "\f76c"; }
+
+.fa-text-slash::before {
+  content: "\f87d"; }
+
+.fa-remove-format::before {
+  content: "\f87d"; }
+
+.fa-face-smile-wink::before {
+  content: "\f4da"; }
+
+.fa-smile-wink::before {
+  content: "\f4da"; }
+
+.fa-file-word::before {
+  content: "\f1c2"; }
+
+.fa-file-powerpoint::before {
+  content: "\f1c4"; }
+
+.fa-arrows-left-right::before {
+  content: "\f07e"; }
+
+.fa-arrows-h::before {
+  content: "\f07e"; }
+
+.fa-house-lock::before {
+  content: "\e510"; }
+
+.fa-cloud-arrow-down::before {
+  content: "\f0ed"; }
+
+.fa-cloud-download::before {
+  content: "\f0ed"; }
+
+.fa-cloud-download-alt::before {
+  content: "\f0ed"; }
+
+.fa-children::before {
+  content: "\e4e1"; }
+
+.fa-chalkboard::before {
+  content: "\f51b"; }
+
+.fa-blackboard::before {
+  content: "\f51b"; }
+
+.fa-user-large-slash::before {
+  content: "\f4fa"; }
+
+.fa-user-alt-slash::before {
+  content: "\f4fa"; }
+
+.fa-envelope-open::before {
+  content: "\f2b6"; }
+
+.fa-handshake-simple-slash::before {
+  content: "\e05f"; }
+
+.fa-handshake-alt-slash::before {
+  content: "\e05f"; }
+
+.fa-mattress-pillow::before {
+  content: "\e525"; }
+
+.fa-guarani-sign::before {
+  content: "\e19a"; }
+
+.fa-arrows-rotate::before {
+  content: "\f021"; }
+
+.fa-refresh::before {
+  content: "\f021"; }
+
+.fa-sync::before {
+  content: "\f021"; }
+
+.fa-fire-extinguisher::before {
+  content: "\f134"; }
+
+.fa-cruzeiro-sign::before {
+  content: "\e152"; }
+
+.fa-greater-than-equal::before {
+  content: "\f532"; }
+
+.fa-shield-halved::before {
+  content: "\f3ed"; }
+
+.fa-shield-alt::before {
+  content: "\f3ed"; }
+
+.fa-book-atlas::before {
+  content: "\f558"; }
+
+.fa-atlas::before {
+  content: "\f558"; }
+
+.fa-virus::before {
+  content: "\e074"; }
+
+.fa-envelope-circle-check::before {
+  content: "\e4e8"; }
+
+.fa-layer-group::before {
+  content: "\f5fd"; }
+
+.fa-arrows-to-dot::before {
+  content: "\e4be"; }
+
+.fa-archway::before {
+  content: "\f557"; }
+
+.fa-heart-circle-check::before {
+  content: "\e4fd"; }
+
+.fa-house-chimney-crack::before {
+  content: "\f6f1"; }
+
+.fa-house-damage::before {
+  content: "\f6f1"; }
+
+.fa-file-zipper::before {
+  content: "\f1c6"; }
+
+.fa-file-archive::before {
+  content: "\f1c6"; }
+
+.fa-square::before {
+  content: "\f0c8"; }
+
+.fa-martini-glass-empty::before {
+  content: "\f000"; }
+
+.fa-glass-martini::before {
+  content: "\f000"; }
+
+.fa-couch::before {
+  content: "\f4b8"; }
+
+.fa-cedi-sign::before {
+  content: "\e0df"; }
+
+.fa-italic::before {
+  content: "\f033"; }
+
+.fa-church::before {
+  content: "\f51d"; }
+
+.fa-comments-dollar::before {
+  content: "\f653"; }
+
+.fa-democrat::before {
+  content: "\f747"; }
+
+.fa-z::before {
+  content: "\5a"; }
+
+.fa-person-skiing::before {
+  content: "\f7c9"; }
+
+.fa-skiing::before {
+  content: "\f7c9"; }
+
+.fa-road-lock::before {
+  content: "\e567"; }
+
+.fa-a::before {
+  content: "\41"; }
+
+.fa-temperature-arrow-down::before {
+  content: "\e03f"; }
+
+.fa-temperature-down::before {
+  content: "\e03f"; }
+
+.fa-feather-pointed::before {
+  content: "\f56b"; }
+
+.fa-feather-alt::before {
+  content: "\f56b"; }
+
+.fa-p::before {
+  content: "\50"; }
+
+.fa-snowflake::before {
+  content: "\f2dc"; }
+
+.fa-newspaper::before {
+  content: "\f1ea"; }
+
+.fa-rectangle-ad::before {
+  content: "\f641"; }
+
+.fa-ad::before {
+  content: "\f641"; }
+
+.fa-circle-arrow-right::before {
+  content: "\f0a9"; }
+
+.fa-arrow-circle-right::before {
+  content: "\f0a9"; }
+
+.fa-filter-circle-xmark::before {
+  content: "\e17b"; }
+
+.fa-locust::before {
+  content: "\e520"; }
+
+.fa-sort::before {
+  content: "\f0dc"; }
+
+.fa-unsorted::before {
+  content: "\f0dc"; }
+
+.fa-list-ol::before {
+  content: "\f0cb"; }
+
+.fa-list-1-2::before {
+  content: "\f0cb"; }
+
+.fa-list-numeric::before {
+  content: "\f0cb"; }
+
+.fa-person-dress-burst::before {
+  content: "\e544"; }
+
+.fa-money-check-dollar::before {
+  content: "\f53d"; }
+
+.fa-money-check-alt::before {
+  content: "\f53d"; }
+
+.fa-vector-square::before {
+  content: "\f5cb"; }
+
+.fa-bread-slice::before {
+  content: "\f7ec"; }
+
+.fa-language::before {
+  content: "\f1ab"; }
+
+.fa-face-kiss-wink-heart::before {
+  content: "\f598"; }
+
+.fa-kiss-wink-heart::before {
+  content: "\f598"; }
+
+.fa-filter::before {
+  content: "\f0b0"; }
+
+.fa-question::before {
+  content: "\3f"; }
+
+.fa-file-signature::before {
+  content: "\f573"; }
+
+.fa-up-down-left-right::before {
+  content: "\f0b2"; }
+
+.fa-arrows-alt::before {
+  content: "\f0b2"; }
+
+.fa-house-chimney-user::before {
+  content: "\e065"; }
+
+.fa-hand-holding-heart::before {
+  content: "\f4be"; }
+
+.fa-puzzle-piece::before {
+  content: "\f12e"; }
+
+.fa-money-check::before {
+  content: "\f53c"; }
+
+.fa-star-half-stroke::before {
+  content: "\f5c0"; }
+
+.fa-star-half-alt::before {
+  content: "\f5c0"; }
+
+.fa-code::before {
+  content: "\f121"; }
+
+.fa-whiskey-glass::before {
+  content: "\f7a0"; }
+
+.fa-glass-whiskey::before {
+  content: "\f7a0"; }
+
+.fa-building-circle-exclamation::before {
+  content: "\e4d3"; }
+
+.fa-magnifying-glass-chart::before {
+  content: "\e522"; }
+
+.fa-arrow-up-right-from-square::before {
+  content: "\f08e"; }
+
+.fa-external-link::before {
+  content: "\f08e"; }
+
+.fa-cubes-stacked::before {
+  content: "\e4e6"; }
+
+.fa-won-sign::before {
+  content: "\f159"; }
+
+.fa-krw::before {
+  content: "\f159"; }
+
+.fa-won::before {
+  content: "\f159"; }
+
+.fa-virus-covid::before {
+  content: "\e4a8"; }
+
+.fa-austral-sign::before {
+  content: "\e0a9"; }
+
+.fa-f::before {
+  content: "\46"; }
+
+.fa-leaf::before {
+  content: "\f06c"; }
+
+.fa-road::before {
+  content: "\f018"; }
+
+.fa-taxi::before {
+  content: "\f1ba"; }
+
+.fa-cab::before {
+  content: "\f1ba"; }
+
+.fa-person-circle-plus::before {
+  content: "\e541"; }
+
+.fa-chart-pie::before {
+  content: "\f200"; }
+
+.fa-pie-chart::before {
+  content: "\f200"; }
+
+.fa-bolt-lightning::before {
+  content: "\e0b7"; }
+
+.fa-sack-xmark::before {
+  content: "\e56a"; }
+
+.fa-file-excel::before {
+  content: "\f1c3"; }
+
+.fa-file-contract::before {
+  content: "\f56c"; }
+
+.fa-fish-fins::before {
+  content: "\e4f2"; }
+
+.fa-building-flag::before {
+  content: "\e4d5"; }
+
+.fa-face-grin-beam::before {
+  content: "\f582"; }
+
+.fa-grin-beam::before {
+  content: "\f582"; }
+
+.fa-object-ungroup::before {
+  content: "\f248"; }
+
+.fa-poop::before {
+  content: "\f619"; }
+
+.fa-location-pin::before {
+  content: "\f041"; }
+
+.fa-map-marker::before {
+  content: "\f041"; }
+
+.fa-kaaba::before {
+  content: "\f66b"; }
+
+.fa-toilet-paper::before {
+  content: "\f71e"; }
+
+.fa-helmet-safety::before {
+  content: "\f807"; }
+
+.fa-hard-hat::before {
+  content: "\f807"; }
+
+.fa-hat-hard::before {
+  content: "\f807"; }
+
+.fa-eject::before {
+  content: "\f052"; }
+
+.fa-circle-right::before {
+  content: "\f35a"; }
+
+.fa-arrow-alt-circle-right::before {
+  content: "\f35a"; }
+
+.fa-plane-circle-check::before {
+  content: "\e555"; }
+
+.fa-face-rolling-eyes::before {
+  content: "\f5a5"; }
+
+.fa-meh-rolling-eyes::before {
+  content: "\f5a5"; }
+
+.fa-object-group::before {
+  content: "\f247"; }
+
+.fa-chart-line::before {
+  content: "\f201"; }
+
+.fa-line-chart::before {
+  content: "\f201"; }
+
+.fa-mask-ventilator::before {
+  content: "\e524"; }
+
+.fa-arrow-right::before {
+  content: "\f061"; }
+
+.fa-signs-post::before {
+  content: "\f277"; }
+
+.fa-map-signs::before {
+  content: "\f277"; }
+
+.fa-cash-register::before {
+  content: "\f788"; }
+
+.fa-person-circle-question::before {
+  content: "\e542"; }
+
+.fa-h::before {
+  content: "\48"; }
+
+.fa-tarp::before {
+  content: "\e57b"; }
+
+.fa-screwdriver-wrench::before {
+  content: "\f7d9"; }
+
+.fa-tools::before {
+  content: "\f7d9"; }
+
+.fa-arrows-to-eye::before {
+  content: "\e4bf"; }
+
+.fa-plug-circle-bolt::before {
+  content: "\e55b"; }
+
+.fa-heart::before {
+  content: "\f004"; }
+
+.fa-mars-and-venus::before {
+  content: "\f224"; }
+
+.fa-house-user::before {
+  content: "\e1b0"; }
+
+.fa-home-user::before {
+  content: "\e1b0"; }
+
+.fa-dumpster-fire::before {
+  content: "\f794"; }
+
+.fa-house-crack::before {
+  content: "\e3b1"; }
+
+.fa-martini-glass-citrus::before {
+  content: "\f561"; }
+
+.fa-cocktail::before {
+  content: "\f561"; }
+
+.fa-face-surprise::before {
+  content: "\f5c2"; }
+
+.fa-surprise::before {
+  content: "\f5c2"; }
+
+.fa-bottle-water::before {
+  content: "\e4c5"; }
+
+.fa-circle-pause::before {
+  content: "\f28b"; }
+
+.fa-pause-circle::before {
+  content: "\f28b"; }
+
+.fa-toilet-paper-slash::before {
+  content: "\e072"; }
+
+.fa-apple-whole::before {
+  content: "\f5d1"; }
+
+.fa-apple-alt::before {
+  content: "\f5d1"; }
+
+.fa-kitchen-set::before {
+  content: "\e51a"; }
+
+.fa-r::before {
+  content: "\52"; }
+
+.fa-temperature-quarter::before {
+  content: "\f2ca"; }
+
+.fa-temperature-1::before {
+  content: "\f2ca"; }
+
+.fa-thermometer-1::before {
+  content: "\f2ca"; }
+
+.fa-thermometer-quarter::before {
+  content: "\f2ca"; }
+
+.fa-cube::before {
+  content: "\f1b2"; }
+
+.fa-bitcoin-sign::before {
+  content: "\e0b4"; }
+
+.fa-shield-dog::before {
+  content: "\e573"; }
+
+.fa-solar-panel::before {
+  content: "\f5ba"; }
+
+.fa-lock-open::before {
+  content: "\f3c1"; }
+
+.fa-elevator::before {
+  content: "\e16d"; }
+
+.fa-money-bill-transfer::before {
+  content: "\e528"; }
+
+.fa-money-bill-trend-up::before {
+  content: "\e529"; }
+
+.fa-house-flood-water-circle-arrow-right::before {
+  content: "\e50f"; }
+
+.fa-square-poll-horizontal::before {
+  content: "\f682"; }
+
+.fa-poll-h::before {
+  content: "\f682"; }
+
+.fa-circle::before {
+  content: "\f111"; }
+
+.fa-backward-fast::before {
+  content: "\f049"; }
+
+.fa-fast-backward::before {
+  content: "\f049"; }
+
+.fa-recycle::before {
+  content: "\f1b8"; }
+
+.fa-user-astronaut::before {
+  content: "\f4fb"; }
+
+.fa-plane-slash::before {
+  content: "\e069"; }
+
+.fa-trademark::before {
+  content: "\f25c"; }
+
+.fa-basketball::before {
+  content: "\f434"; }
+
+.fa-basketball-ball::before {
+  content: "\f434"; }
+
+.fa-satellite-dish::before {
+  content: "\f7c0"; }
+
+.fa-circle-up::before {
+  content: "\f35b"; }
+
+.fa-arrow-alt-circle-up::before {
+  content: "\f35b"; }
+
+.fa-mobile-screen-button::before {
+  content: "\f3cd"; }
+
+.fa-mobile-alt::before {
+  content: "\f3cd"; }
+
+.fa-volume-high::before {
+  content: "\f028"; }
+
+.fa-volume-up::before {
+  content: "\f028"; }
+
+.fa-users-rays::before {
+  content: "\e593"; }
+
+.fa-wallet::before {
+  content: "\f555"; }
+
+.fa-clipboard-check::before {
+  content: "\f46c"; }
+
+.fa-file-audio::before {
+  content: "\f1c7"; }
+
+.fa-burger::before {
+  content: "\f805"; }
+
+.fa-hamburger::before {
+  content: "\f805"; }
+
+.fa-wrench::before {
+  content: "\f0ad"; }
+
+.fa-bugs::before {
+  content: "\e4d0"; }
+
+.fa-rupee-sign::before {
+  content: "\f156"; }
+
+.fa-rupee::before {
+  content: "\f156"; }
+
+.fa-file-image::before {
+  content: "\f1c5"; }
+
+.fa-circle-question::before {
+  content: "\f059"; }
+
+.fa-question-circle::before {
+  content: "\f059"; }
+
+.fa-plane-departure::before {
+  content: "\f5b0"; }
+
+.fa-handshake-slash::before {
+  content: "\e060"; }
+
+.fa-book-bookmark::before {
+  content: "\e0bb"; }
+
+.fa-code-branch::before {
+  content: "\f126"; }
+
+.fa-hat-cowboy::before {
+  content: "\f8c0"; }
+
+.fa-bridge::before {
+  content: "\e4c8"; }
+
+.fa-phone-flip::before {
+  content: "\f879"; }
+
+.fa-phone-alt::before {
+  content: "\f879"; }
+
+.fa-truck-front::before {
+  content: "\e2b7"; }
+
+.fa-cat::before {
+  content: "\f6be"; }
+
+.fa-anchor-circle-exclamation::before {
+  content: "\e4ab"; }
+
+.fa-truck-field::before {
+  content: "\e58d"; }
+
+.fa-route::before {
+  content: "\f4d7"; }
+
+.fa-clipboard-question::before {
+  content: "\e4e3"; }
+
+.fa-panorama::before {
+  content: "\e209"; }
+
+.fa-comment-medical::before {
+  content: "\f7f5"; }
+
+.fa-teeth-open::before {
+  content: "\f62f"; }
+
+.fa-file-circle-minus::before {
+  content: "\e4ed"; }
+
+.fa-tags::before {
+  content: "\f02c"; }
+
+.fa-wine-glass::before {
+  content: "\f4e3"; }
+
+.fa-forward-fast::before {
+  content: "\f050"; }
+
+.fa-fast-forward::before {
+  content: "\f050"; }
+
+.fa-face-meh-blank::before {
+  content: "\f5a4"; }
+
+.fa-meh-blank::before {
+  content: "\f5a4"; }
+
+.fa-square-parking::before {
+  content: "\f540"; }
+
+.fa-parking::before {
+  content: "\f540"; }
+
+.fa-house-signal::before {
+  content: "\e012"; }
+
+.fa-bars-progress::before {
+  content: "\f828"; }
+
+.fa-tasks-alt::before {
+  content: "\f828"; }
+
+.fa-faucet-drip::before {
+  content: "\e006"; }
+
+.fa-cart-flatbed::before {
+  content: "\f474"; }
+
+.fa-dolly-flatbed::before {
+  content: "\f474"; }
+
+.fa-ban-smoking::before {
+  content: "\f54d"; }
+
+.fa-smoking-ban::before {
+  content: "\f54d"; }
+
+.fa-terminal::before {
+  content: "\f120"; }
+
+.fa-mobile-button::before {
+  content: "\f10b"; }
+
+.fa-house-medical-flag::before {
+  content: "\e514"; }
+
+.fa-basket-shopping::before {
+  content: "\f291"; }
+
+.fa-shopping-basket::before {
+  content: "\f291"; }
+
+.fa-tape::before {
+  content: "\f4db"; }
+
+.fa-bus-simple::before {
+  content: "\f55e"; }
+
+.fa-bus-alt::before {
+  content: "\f55e"; }
+
+.fa-eye::before {
+  content: "\f06e"; }
+
+.fa-face-sad-cry::before {
+  content: "\f5b3"; }
+
+.fa-sad-cry::before {
+  content: "\f5b3"; }
+
+.fa-audio-description::before {
+  content: "\f29e"; }
+
+.fa-person-military-to-person::before {
+  content: "\e54c"; }
+
+.fa-file-shield::before {
+  content: "\e4f0"; }
+
+.fa-user-slash::before {
+  content: "\f506"; }
+
+.fa-pen::before {
+  content: "\f304"; }
+
+.fa-tower-observation::before {
+  content: "\e586"; }
+
+.fa-file-code::before {
+  content: "\f1c9"; }
+
+.fa-signal::before {
+  content: "\f012"; }
+
+.fa-signal-5::before {
+  content: "\f012"; }
+
+.fa-signal-perfect::before {
+  content: "\f012"; }
+
+.fa-bus::before {
+  content: "\f207"; }
+
+.fa-heart-circle-xmark::before {
+  content: "\e501"; }
+
+.fa-house-chimney::before {
+  content: "\e3af"; }
+
+.fa-home-lg::before {
+  content: "\e3af"; }
+
+.fa-window-maximize::before {
+  content: "\f2d0"; }
+
+.fa-face-frown::before {
+  content: "\f119"; }
+
+.fa-frown::before {
+  content: "\f119"; }
+
+.fa-prescription::before {
+  content: "\f5b1"; }
+
+.fa-shop::before {
+  content: "\f54f"; }
+
+.fa-store-alt::before {
+  content: "\f54f"; }
+
+.fa-floppy-disk::before {
+  content: "\f0c7"; }
+
+.fa-save::before {
+  content: "\f0c7"; }
+
+.fa-vihara::before {
+  content: "\f6a7"; }
+
+.fa-scale-unbalanced::before {
+  content: "\f515"; }
+
+.fa-balance-scale-left::before {
+  content: "\f515"; }
+
+.fa-sort-up::before {
+  content: "\f0de"; }
+
+.fa-sort-asc::before {
+  content: "\f0de"; }
+
+.fa-comment-dots::before {
+  content: "\f4ad"; }
+
+.fa-commenting::before {
+  content: "\f4ad"; }
+
+.fa-plant-wilt::before {
+  content: "\e5aa"; }
+
+.fa-diamond::before {
+  content: "\f219"; }
+
+.fa-face-grin-squint::before {
+  content: "\f585"; }
+
+.fa-grin-squint::before {
+  content: "\f585"; }
+
+.fa-hand-holding-dollar::before {
+  content: "\f4c0"; }
+
+.fa-hand-holding-usd::before {
+  content: "\f4c0"; }
+
+.fa-bacterium::before {
+  content: "\e05a"; }
+
+.fa-hand-pointer::before {
+  content: "\f25a"; }
+
+.fa-drum-steelpan::before {
+  content: "\f56a"; }
+
+.fa-hand-scissors::before {
+  content: "\f257"; }
+
+.fa-hands-praying::before {
+  content: "\f684"; }
+
+.fa-praying-hands::before {
+  content: "\f684"; }
+
+.fa-arrow-rotate-right::before {
+  content: "\f01e"; }
+
+.fa-arrow-right-rotate::before {
+  content: "\f01e"; }
+
+.fa-arrow-rotate-forward::before {
+  content: "\f01e"; }
+
+.fa-redo::before {
+  content: "\f01e"; }
+
+.fa-biohazard::before {
+  content: "\f780"; }
+
+.fa-location-crosshairs::before {
+  content: "\f601"; }
+
+.fa-location::before {
+  content: "\f601"; }
+
+.fa-mars-double::before {
+  content: "\f227"; }
+
+.fa-child-dress::before {
+  content: "\e59c"; }
+
+.fa-users-between-lines::before {
+  content: "\e591"; }
+
+.fa-lungs-virus::before {
+  content: "\e067"; }
+
+.fa-face-grin-tears::before {
+  content: "\f588"; }
+
+.fa-grin-tears::before {
+  content: "\f588"; }
+
+.fa-phone::before {
+  content: "\f095"; }
+
+.fa-calendar-xmark::before {
+  content: "\f273"; }
+
+.fa-calendar-times::before {
+  content: "\f273"; }
+
+.fa-child-reaching::before {
+  content: "\e59d"; }
+
+.fa-head-side-virus::before {
+  content: "\e064"; }
+
+.fa-user-gear::before {
+  content: "\f4fe"; }
+
+.fa-user-cog::before {
+  content: "\f4fe"; }
+
+.fa-arrow-up-1-9::before {
+  content: "\f163"; }
+
+.fa-sort-numeric-up::before {
+  content: "\f163"; }
+
+.fa-door-closed::before {
+  content: "\f52a"; }
+
+.fa-shield-virus::before {
+  content: "\e06c"; }
+
+.fa-dice-six::before {
+  content: "\f526"; }
+
+.fa-mosquito-net::before {
+  content: "\e52c"; }
+
+.fa-bridge-water::before {
+  content: "\e4ce"; }
+
+.fa-person-booth::before {
+  content: "\f756"; }
+
+.fa-text-width::before {
+  content: "\f035"; }
+
+.fa-hat-wizard::before {
+  content: "\f6e8"; }
+
+.fa-pen-fancy::before {
+  content: "\f5ac"; }
+
+.fa-person-digging::before {
+  content: "\f85e"; }
+
+.fa-digging::before {
+  content: "\f85e"; }
+
+.fa-trash::before {
+  content: "\f1f8"; }
+
+.fa-gauge-simple::before {
+  content: "\f629"; }
+
+.fa-gauge-simple-med::before {
+  content: "\f629"; }
+
+.fa-tachometer-average::before {
+  content: "\f629"; }
+
+.fa-book-medical::before {
+  content: "\f7e6"; }
+
+.fa-poo::before {
+  content: "\f2fe"; }
+
+.fa-quote-right::before {
+  content: "\f10e"; }
+
+.fa-quote-right-alt::before {
+  content: "\f10e"; }
+
+.fa-shirt::before {
+  content: "\f553"; }
+
+.fa-t-shirt::before {
+  content: "\f553"; }
+
+.fa-tshirt::before {
+  content: "\f553"; }
+
+.fa-cubes::before {
+  content: "\f1b3"; }
+
+.fa-divide::before {
+  content: "\f529"; }
+
+.fa-tenge-sign::before {
+  content: "\f7d7"; }
+
+.fa-tenge::before {
+  content: "\f7d7"; }
+
+.fa-headphones::before {
+  content: "\f025"; }
+
+.fa-hands-holding::before {
+  content: "\f4c2"; }
+
+.fa-hands-clapping::before {
+  content: "\e1a8"; }
+
+.fa-republican::before {
+  content: "\f75e"; }
+
+.fa-arrow-left::before {
+  content: "\f060"; }
+
+.fa-person-circle-xmark::before {
+  content: "\e543"; }
+
+.fa-ruler::before {
+  content: "\f545"; }
+
+.fa-align-left::before {
+  content: "\f036"; }
+
+.fa-dice-d6::before {
+  content: "\f6d1"; }
+
+.fa-restroom::before {
+  content: "\f7bd"; }
+
+.fa-j::before {
+  content: "\4a"; }
+
+.fa-users-viewfinder::before {
+  content: "\e595"; }
+
+.fa-file-video::before {
+  content: "\f1c8"; }
+
+.fa-up-right-from-square::before {
+  content: "\f35d"; }
+
+.fa-external-link-alt::before {
+  content: "\f35d"; }
+
+.fa-table-cells::before {
+  content: "\f00a"; }
+
+.fa-th::before {
+  content: "\f00a"; }
+
+.fa-file-pdf::before {
+  content: "\f1c1"; }
+
+.fa-book-bible::before {
+  content: "\f647"; }
+
+.fa-bible::before {
+  content: "\f647"; }
+
+.fa-o::before {
+  content: "\4f"; }
+
+.fa-suitcase-medical::before {
+  content: "\f0fa"; }
+
+.fa-medkit::before {
+  content: "\f0fa"; }
+
+.fa-user-secret::before {
+  content: "\f21b"; }
+
+.fa-otter::before {
+  content: "\f700"; }
+
+.fa-person-dress::before {
+  content: "\f182"; }
+
+.fa-female::before {
+  content: "\f182"; }
+
+.fa-comment-dollar::before {
+  content: "\f651"; }
+
+.fa-business-time::before {
+  content: "\f64a"; }
+
+.fa-briefcase-clock::before {
+  content: "\f64a"; }
+
+.fa-table-cells-large::before {
+  content: "\f009"; }
+
+.fa-th-large::before {
+  content: "\f009"; }
+
+.fa-book-tanakh::before {
+  content: "\f827"; }
+
+.fa-tanakh::before {
+  content: "\f827"; }
+
+.fa-phone-volume::before {
+  content: "\f2a0"; }
+
+.fa-volume-control-phone::before {
+  content: "\f2a0"; }
+
+.fa-hat-cowboy-side::before {
+  content: "\f8c1"; }
+
+.fa-clipboard-user::before {
+  content: "\f7f3"; }
+
+.fa-child::before {
+  content: "\f1ae"; }
+
+.fa-lira-sign::before {
+  content: "\f195"; }
+
+.fa-satellite::before {
+  content: "\f7bf"; }
+
+.fa-plane-lock::before {
+  content: "\e558"; }
+
+.fa-tag::before {
+  content: "\f02b"; }
+
+.fa-comment::before {
+  content: "\f075"; }
+
+.fa-cake-candles::before {
+  content: "\f1fd"; }
+
+.fa-birthday-cake::before {
+  content: "\f1fd"; }
+
+.fa-cake::before {
+  content: "\f1fd"; }
+
+.fa-envelope::before {
+  content: "\f0e0"; }
+
+.fa-angles-up::before {
+  content: "\f102"; }
+
+.fa-angle-double-up::before {
+  content: "\f102"; }
+
+.fa-paperclip::before {
+  content: "\f0c6"; }
+
+.fa-arrow-right-to-city::before {
+  content: "\e4b3"; }
+
+.fa-ribbon::before {
+  content: "\f4d6"; }
+
+.fa-lungs::before {
+  content: "\f604"; }
+
+.fa-arrow-up-9-1::before {
+  content: "\f887"; }
+
+.fa-sort-numeric-up-alt::before {
+  content: "\f887"; }
+
+.fa-litecoin-sign::before {
+  content: "\e1d3"; }
+
+.fa-border-none::before {
+  content: "\f850"; }
+
+.fa-circle-nodes::before {
+  content: "\e4e2"; }
+
+.fa-parachute-box::before {
+  content: "\f4cd"; }
+
+.fa-indent::before {
+  content: "\f03c"; }
+
+.fa-truck-field-un::before {
+  content: "\e58e"; }
+
+.fa-hourglass::before {
+  content: "\f254"; }
+
+.fa-hourglass-empty::before {
+  content: "\f254"; }
+
+.fa-mountain::before {
+  content: "\f6fc"; }
+
+.fa-user-doctor::before {
+  content: "\f0f0"; }
+
+.fa-user-md::before {
+  content: "\f0f0"; }
+
+.fa-circle-info::before {
+  content: "\f05a"; }
+
+.fa-info-circle::before {
+  content: "\f05a"; }
+
+.fa-cloud-meatball::before {
+  content: "\f73b"; }
+
+.fa-camera::before {
+  content: "\f030"; }
+
+.fa-camera-alt::before {
+  content: "\f030"; }
+
+.fa-square-virus::before {
+  content: "\e578"; }
+
+.fa-meteor::before {
+  content: "\f753"; }
+
+.fa-car-on::before {
+  content: "\e4dd"; }
+
+.fa-sleigh::before {
+  content: "\f7cc"; }
+
+.fa-arrow-down-1-9::before {
+  content: "\f162"; }
+
+.fa-sort-numeric-asc::before {
+  content: "\f162"; }
+
+.fa-sort-numeric-down::before {
+  content: "\f162"; }
+
+.fa-hand-holding-droplet::before {
+  content: "\f4c1"; }
+
+.fa-hand-holding-water::before {
+  content: "\f4c1"; }
+
+.fa-water::before {
+  content: "\f773"; }
+
+.fa-calendar-check::before {
+  content: "\f274"; }
+
+.fa-braille::before {
+  content: "\f2a1"; }
+
+.fa-prescription-bottle-medical::before {
+  content: "\f486"; }
+
+.fa-prescription-bottle-alt::before {
+  content: "\f486"; }
+
+.fa-landmark::before {
+  content: "\f66f"; }
+
+.fa-truck::before {
+  content: "\f0d1"; }
+
+.fa-crosshairs::before {
+  content: "\f05b"; }
+
+.fa-person-cane::before {
+  content: "\e53c"; }
+
+.fa-tent::before {
+  content: "\e57d"; }
+
+.fa-vest-patches::before {
+  content: "\e086"; }
+
+.fa-check-double::before {
+  content: "\f560"; }
+
+.fa-arrow-down-a-z::before {
+  content: "\f15d"; }
+
+.fa-sort-alpha-asc::before {
+  content: "\f15d"; }
+
+.fa-sort-alpha-down::before {
+  content: "\f15d"; }
+
+.fa-money-bill-wheat::before {
+  content: "\e52a"; }
+
+.fa-cookie::before {
+  content: "\f563"; }
+
+.fa-arrow-rotate-left::before {
+  content: "\f0e2"; }
+
+.fa-arrow-left-rotate::before {
+  content: "\f0e2"; }
+
+.fa-arrow-rotate-back::before {
+  content: "\f0e2"; }
+
+.fa-arrow-rotate-backward::before {
+  content: "\f0e2"; }
+
+.fa-undo::before {
+  content: "\f0e2"; }
+
+.fa-hard-drive::before {
+  content: "\f0a0"; }
+
+.fa-hdd::before {
+  content: "\f0a0"; }
+
+.fa-face-grin-squint-tears::before {
+  content: "\f586"; }
+
+.fa-grin-squint-tears::before {
+  content: "\f586"; }
+
+.fa-dumbbell::before {
+  content: "\f44b"; }
+
+.fa-rectangle-list::before {
+  content: "\f022"; }
+
+.fa-list-alt::before {
+  content: "\f022"; }
+
+.fa-tarp-droplet::before {
+  content: "\e57c"; }
+
+.fa-house-medical-circle-check::before {
+  content: "\e511"; }
+
+.fa-person-skiing-nordic::before {
+  content: "\f7ca"; }
+
+.fa-skiing-nordic::before {
+  content: "\f7ca"; }
+
+.fa-calendar-plus::before {
+  content: "\f271"; }
+
+.fa-plane-arrival::before {
+  content: "\f5af"; }
+
+.fa-circle-left::before {
+  content: "\f359"; }
+
+.fa-arrow-alt-circle-left::before {
+  content: "\f359"; }
+
+.fa-train-subway::before {
+  content: "\f239"; }
+
+.fa-subway::before {
+  content: "\f239"; }
+
+.fa-chart-gantt::before {
+  content: "\e0e4"; }
+
+.fa-indian-rupee-sign::before {
+  content: "\e1bc"; }
+
+.fa-indian-rupee::before {
+  content: "\e1bc"; }
+
+.fa-inr::before {
+  content: "\e1bc"; }
+
+.fa-crop-simple::before {
+  content: "\f565"; }
+
+.fa-crop-alt::before {
+  content: "\f565"; }
+
+.fa-money-bill-1::before {
+  content: "\f3d1"; }
+
+.fa-money-bill-alt::before {
+  content: "\f3d1"; }
+
+.fa-left-long::before {
+  content: "\f30a"; }
+
+.fa-long-arrow-alt-left::before {
+  content: "\f30a"; }
+
+.fa-dna::before {
+  content: "\f471"; }
+
+.fa-virus-slash::before {
+  content: "\e075"; }
+
+.fa-minus::before {
+  content: "\f068"; }
+
+.fa-subtract::before {
+  content: "\f068"; }
+
+.fa-chess::before {
+  content: "\f439"; }
+
+.fa-arrow-left-long::before {
+  content: "\f177"; }
+
+.fa-long-arrow-left::before {
+  content: "\f177"; }
+
+.fa-plug-circle-check::before {
+  content: "\e55c"; }
+
+.fa-street-view::before {
+  content: "\f21d"; }
+
+.fa-franc-sign::before {
+  content: "\e18f"; }
+
+.fa-volume-off::before {
+  content: "\f026"; }
+
+.fa-hands-asl-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-american-sign-language-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-asl-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-hands-american-sign-language-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-gear::before {
+  content: "\f013"; }
+
+.fa-cog::before {
+  content: "\f013"; }
+
+.fa-droplet-slash::before {
+  content: "\f5c7"; }
+
+.fa-tint-slash::before {
+  content: "\f5c7"; }
+
+.fa-mosque::before {
+  content: "\f678"; }
+
+.fa-mosquito::before {
+  content: "\e52b"; }
+
+.fa-star-of-david::before {
+  content: "\f69a"; }
+
+.fa-person-military-rifle::before {
+  content: "\e54b"; }
+
+.fa-cart-shopping::before {
+  content: "\f07a"; }
+
+.fa-shopping-cart::before {
+  content: "\f07a"; }
+
+.fa-vials::before {
+  content: "\f493"; }
+
+.fa-plug-circle-plus::before {
+  content: "\e55f"; }
+
+.fa-place-of-worship::before {
+  content: "\f67f"; }
+
+.fa-grip-vertical::before {
+  content: "\f58e"; }
+
+.fa-arrow-turn-up::before {
+  content: "\f148"; }
+
+.fa-level-up::before {
+  content: "\f148"; }
+
+.fa-u::before {
+  content: "\55"; }
+
+.fa-square-root-variable::before {
+  content: "\f698"; }
+
+.fa-square-root-alt::before {
+  content: "\f698"; }
+
+.fa-clock::before {
+  content: "\f017"; }
+
+.fa-clock-four::before {
+  content: "\f017"; }
+
+.fa-backward-step::before {
+  content: "\f048"; }
+
+.fa-step-backward::before {
+  content: "\f048"; }
+
+.fa-pallet::before {
+  content: "\f482"; }
+
+.fa-faucet::before {
+  content: "\e005"; }
+
+.fa-baseball-bat-ball::before {
+  content: "\f432"; }
+
+.fa-s::before {
+  content: "\53"; }
+
+.fa-timeline::before {
+  content: "\e29c"; }
+
+.fa-keyboard::before {
+  content: "\f11c"; }
+
+.fa-caret-down::before {
+  content: "\f0d7"; }
+
+.fa-house-chimney-medical::before {
+  content: "\f7f2"; }
+
+.fa-clinic-medical::before {
+  content: "\f7f2"; }
+
+.fa-temperature-three-quarters::before {
+  content: "\f2c8"; }
+
+.fa-temperature-3::before {
+  content: "\f2c8"; }
+
+.fa-thermometer-3::before {
+  content: "\f2c8"; }
+
+.fa-thermometer-three-quarters::before {
+  content: "\f2c8"; }
+
+.fa-mobile-screen::before {
+  content: "\f3cf"; }
+
+.fa-mobile-android-alt::before {
+  content: "\f3cf"; }
+
+.fa-plane-up::before {
+  content: "\e22d"; }
+
+.fa-piggy-bank::before {
+  content: "\f4d3"; }
+
+.fa-battery-half::before {
+  content: "\f242"; }
+
+.fa-battery-3::before {
+  content: "\f242"; }
+
+.fa-mountain-city::before {
+  content: "\e52e"; }
+
+.fa-coins::before {
+  content: "\f51e"; }
+
+.fa-khanda::before {
+  content: "\f66d"; }
+
+.fa-sliders::before {
+  content: "\f1de"; }
+
+.fa-sliders-h::before {
+  content: "\f1de"; }
+
+.fa-folder-tree::before {
+  content: "\f802"; }
+
+.fa-network-wired::before {
+  content: "\f6ff"; }
+
+.fa-map-pin::before {
+  content: "\f276"; }
+
+.fa-hamsa::before {
+  content: "\f665"; }
+
+.fa-cent-sign::before {
+  content: "\e3f5"; }
+
+.fa-flask::before {
+  content: "\f0c3"; }
+
+.fa-person-pregnant::before {
+  content: "\e31e"; }
+
+.fa-wand-sparkles::before {
+  content: "\f72b"; }
+
+.fa-ellipsis-vertical::before {
+  content: "\f142"; }
+
+.fa-ellipsis-v::before {
+  content: "\f142"; }
+
+.fa-ticket::before {
+  content: "\f145"; }
+
+.fa-power-off::before {
+  content: "\f011"; }
+
+.fa-right-long::before {
+  content: "\f30b"; }
+
+.fa-long-arrow-alt-right::before {
+  content: "\f30b"; }
+
+.fa-flag-usa::before {
+  content: "\f74d"; }
+
+.fa-laptop-file::before {
+  content: "\e51d"; }
+
+.fa-tty::before {
+  content: "\f1e4"; }
+
+.fa-teletype::before {
+  content: "\f1e4"; }
+
+.fa-diagram-next::before {
+  content: "\e476"; }
+
+.fa-person-rifle::before {
+  content: "\e54e"; }
+
+.fa-house-medical-circle-exclamation::before {
+  content: "\e512"; }
+
+.fa-closed-captioning::before {
+  content: "\f20a"; }
+
+.fa-person-hiking::before {
+  content: "\f6ec"; }
+
+.fa-hiking::before {
+  content: "\f6ec"; }
+
+.fa-venus-double::before {
+  content: "\f226"; }
+
+.fa-images::before {
+  content: "\f302"; }
+
+.fa-calculator::before {
+  content: "\f1ec"; }
+
+.fa-people-pulling::before {
+  content: "\e535"; }
+
+.fa-n::before {
+  content: "\4e"; }
+
+.fa-cable-car::before {
+  content: "\f7da"; }
+
+.fa-tram::before {
+  content: "\f7da"; }
+
+.fa-cloud-rain::before {
+  content: "\f73d"; }
+
+.fa-building-circle-xmark::before {
+  content: "\e4d4"; }
+
+.fa-ship::before {
+  content: "\f21a"; }
+
+.fa-arrows-down-to-line::before {
+  content: "\e4b8"; }
+
+.fa-download::before {
+  content: "\f019"; }
+
+.fa-face-grin::before {
+  content: "\f580"; }
+
+.fa-grin::before {
+  content: "\f580"; }
+
+.fa-delete-left::before {
+  content: "\f55a"; }
+
+.fa-backspace::before {
+  content: "\f55a"; }
+
+.fa-eye-dropper::before {
+  content: "\f1fb"; }
+
+.fa-eye-dropper-empty::before {
+  content: "\f1fb"; }
+
+.fa-eyedropper::before {
+  content: "\f1fb"; }
+
+.fa-file-circle-check::before {
+  content: "\e5a0"; }
+
+.fa-forward::before {
+  content: "\f04e"; }
+
+.fa-mobile::before {
+  content: "\f3ce"; }
+
+.fa-mobile-android::before {
+  content: "\f3ce"; }
+
+.fa-mobile-phone::before {
+  content: "\f3ce"; }
+
+.fa-face-meh::before {
+  content: "\f11a"; }
+
+.fa-meh::before {
+  content: "\f11a"; }
+
+.fa-align-center::before {
+  content: "\f037"; }
+
+.fa-book-skull::before {
+  content: "\f6b7"; }
+
+.fa-book-dead::before {
+  content: "\f6b7"; }
+
+.fa-id-card::before {
+  content: "\f2c2"; }
+
+.fa-drivers-license::before {
+  content: "\f2c2"; }
+
+.fa-outdent::before {
+  content: "\f03b"; }
+
+.fa-dedent::before {
+  content: "\f03b"; }
+
+.fa-heart-circle-exclamation::before {
+  content: "\e4fe"; }
+
+.fa-house::before {
+  content: "\f015"; }
+
+.fa-home::before {
+  content: "\f015"; }
+
+.fa-home-alt::before {
+  content: "\f015"; }
+
+.fa-home-lg-alt::before {
+  content: "\f015"; }
+
+.fa-calendar-week::before {
+  content: "\f784"; }
+
+.fa-laptop-medical::before {
+  content: "\f812"; }
+
+.fa-b::before {
+  content: "\42"; }
+
+.fa-file-medical::before {
+  content: "\f477"; }
+
+.fa-dice-one::before {
+  content: "\f525"; }
+
+.fa-kiwi-bird::before {
+  content: "\f535"; }
+
+.fa-arrow-right-arrow-left::before {
+  content: "\f0ec"; }
+
+.fa-exchange::before {
+  content: "\f0ec"; }
+
+.fa-rotate-right::before {
+  content: "\f2f9"; }
+
+.fa-redo-alt::before {
+  content: "\f2f9"; }
+
+.fa-rotate-forward::before {
+  content: "\f2f9"; }
+
+.fa-utensils::before {
+  content: "\f2e7"; }
+
+.fa-cutlery::before {
+  content: "\f2e7"; }
+
+.fa-arrow-up-wide-short::before {
+  content: "\f161"; }
+
+.fa-sort-amount-up::before {
+  content: "\f161"; }
+
+.fa-mill-sign::before {
+  content: "\e1ed"; }
+
+.fa-bowl-rice::before {
+  content: "\e2eb"; }
+
+.fa-skull::before {
+  content: "\f54c"; }
+
+.fa-tower-broadcast::before {
+  content: "\f519"; }
+
+.fa-broadcast-tower::before {
+  content: "\f519"; }
+
+.fa-truck-pickup::before {
+  content: "\f63c"; }
+
+.fa-up-long::before {
+  content: "\f30c"; }
+
+.fa-long-arrow-alt-up::before {
+  content: "\f30c"; }
+
+.fa-stop::before {
+  content: "\f04d"; }
+
+.fa-code-merge::before {
+  content: "\f387"; }
+
+.fa-upload::before {
+  content: "\f093"; }
+
+.fa-hurricane::before {
+  content: "\f751"; }
+
+.fa-mound::before {
+  content: "\e52d"; }
+
+.fa-toilet-portable::before {
+  content: "\e583"; }
+
+.fa-compact-disc::before {
+  content: "\f51f"; }
+
+.fa-file-arrow-down::before {
+  content: "\f56d"; }
+
+.fa-file-download::before {
+  content: "\f56d"; }
+
+.fa-caravan::before {
+  content: "\f8ff"; }
+
+.fa-shield-cat::before {
+  content: "\e572"; }
+
+.fa-bolt::before {
+  content: "\f0e7"; }
+
+.fa-zap::before {
+  content: "\f0e7"; }
+
+.fa-glass-water::before {
+  content: "\e4f4"; }
+
+.fa-oil-well::before {
+  content: "\e532"; }
+
+.fa-vault::before {
+  content: "\e2c5"; }
+
+.fa-mars::before {
+  content: "\f222"; }
+
+.fa-toilet::before {
+  content: "\f7d8"; }
+
+.fa-plane-circle-xmark::before {
+  content: "\e557"; }
+
+.fa-yen-sign::before {
+  content: "\f157"; }
+
+.fa-cny::before {
+  content: "\f157"; }
+
+.fa-jpy::before {
+  content: "\f157"; }
+
+.fa-rmb::before {
+  content: "\f157"; }
+
+.fa-yen::before {
+  content: "\f157"; }
+
+.fa-ruble-sign::before {
+  content: "\f158"; }
+
+.fa-rouble::before {
+  content: "\f158"; }
+
+.fa-rub::before {
+  content: "\f158"; }
+
+.fa-ruble::before {
+  content: "\f158"; }
+
+.fa-sun::before {
+  content: "\f185"; }
+
+.fa-guitar::before {
+  content: "\f7a6"; }
+
+.fa-face-laugh-wink::before {
+  content: "\f59c"; }
+
+.fa-laugh-wink::before {
+  content: "\f59c"; }
+
+.fa-horse-head::before {
+  content: "\f7ab"; }
+
+.fa-bore-hole::before {
+  content: "\e4c3"; }
+
+.fa-industry::before {
+  content: "\f275"; }
+
+.fa-circle-down::before {
+  content: "\f358"; }
+
+.fa-arrow-alt-circle-down::before {
+  content: "\f358"; }
+
+.fa-arrows-turn-to-dots::before {
+  content: "\e4c1"; }
+
+.fa-florin-sign::before {
+  content: "\e184"; }
+
+.fa-arrow-down-short-wide::before {
+  content: "\f884"; }
+
+.fa-sort-amount-desc::before {
+  content: "\f884"; }
+
+.fa-sort-amount-down-alt::before {
+  content: "\f884"; }
+
+.fa-less-than::before {
+  content: "\3c"; }
+
+.fa-angle-down::before {
+  content: "\f107"; }
+
+.fa-car-tunnel::before {
+  content: "\e4de"; }
+
+.fa-head-side-cough::before {
+  content: "\e061"; }
+
+.fa-grip-lines::before {
+  content: "\f7a4"; }
+
+.fa-thumbs-down::before {
+  content: "\f165"; }
+
+.fa-user-lock::before {
+  content: "\f502"; }
+
+.fa-arrow-right-long::before {
+  content: "\f178"; }
+
+.fa-long-arrow-right::before {
+  content: "\f178"; }
+
+.fa-anchor-circle-xmark::before {
+  content: "\e4ac"; }
+
+.fa-ellipsis::before {
+  content: "\f141"; }
+
+.fa-ellipsis-h::before {
+  content: "\f141"; }
+
+.fa-chess-pawn::before {
+  content: "\f443"; }
+
+.fa-kit-medical::before {
+  content: "\f479"; }
+
+.fa-first-aid::before {
+  content: "\f479"; }
+
+.fa-person-through-window::before {
+  content: "\e5a9"; }
+
+.fa-toolbox::before {
+  content: "\f552"; }
+
+.fa-hands-holding-circle::before {
+  content: "\e4fb"; }
+
+.fa-bug::before {
+  content: "\f188"; }
+
+.fa-credit-card::before {
+  content: "\f09d"; }
+
+.fa-credit-card-alt::before {
+  content: "\f09d"; }
+
+.fa-car::before {
+  content: "\f1b9"; }
+
+.fa-automobile::before {
+  content: "\f1b9"; }
+
+.fa-hand-holding-hand::before {
+  content: "\e4f7"; }
+
+.fa-book-open-reader::before {
+  content: "\f5da"; }
+
+.fa-book-reader::before {
+  content: "\f5da"; }
+
+.fa-mountain-sun::before {
+  content: "\e52f"; }
+
+.fa-arrows-left-right-to-line::before {
+  content: "\e4ba"; }
+
+.fa-dice-d20::before {
+  content: "\f6cf"; }
+
+.fa-truck-droplet::before {
+  content: "\e58c"; }
+
+.fa-file-circle-xmark::before {
+  content: "\e5a1"; }
+
+.fa-temperature-arrow-up::before {
+  content: "\e040"; }
+
+.fa-temperature-up::before {
+  content: "\e040"; }
+
+.fa-medal::before {
+  content: "\f5a2"; }
+
+.fa-bed::before {
+  content: "\f236"; }
+
+.fa-square-h::before {
+  content: "\f0fd"; }
+
+.fa-h-square::before {
+  content: "\f0fd"; }
+
+.fa-podcast::before {
+  content: "\f2ce"; }
+
+.fa-temperature-full::before {
+  content: "\f2c7"; }
+
+.fa-temperature-4::before {
+  content: "\f2c7"; }
+
+.fa-thermometer-4::before {
+  content: "\f2c7"; }
+
+.fa-thermometer-full::before {
+  content: "\f2c7"; }
+
+.fa-bell::before {
+  content: "\f0f3"; }
+
+.fa-superscript::before {
+  content: "\f12b"; }
+
+.fa-plug-circle-xmark::before {
+  content: "\e560"; }
+
+.fa-star-of-life::before {
+  content: "\f621"; }
+
+.fa-phone-slash::before {
+  content: "\f3dd"; }
+
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+  content: "\f5aa"; }
+
+.fa-handshake-angle::before {
+  content: "\f4c4"; }
+
+.fa-hands-helping::before {
+  content: "\f4c4"; }
+
+.fa-location-dot::before {
+  content: "\f3c5"; }
+
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+  content: "\f3c5"; }
+
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+  content: "\f15b"; }
+
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+  content: "\3e"; }
+
+.fa-person-swimming::before {
+  content: "\f5c4"; }
+
+.fa-swimmer::before {
+  content: "\f5c4"; }
+
+.fa-arrow-down::before {
+  content: "\f063"; }
+
+.fa-droplet::before {
+  content: "\f043"; }
+
+.fa-tint::before {
+  content: "\f043"; }
+
+.fa-eraser::before {
+  content: "\f12d"; }
+
+.fa-earth-americas::before {
+  content: "\f57d"; }
+
+.fa-earth::before {
+  content: "\f57d"; }
+
+.fa-earth-america::before {
+  content: "\f57d"; }
+
+.fa-globe-americas::before {
+  content: "\f57d"; }
+
+.fa-person-burst::before {
+  content: "\e53b"; }
+
+.fa-dove::before {
+  content: "\f4ba"; }
+
+.fa-battery-empty::before {
+  content: "\f244"; }
+
+.fa-battery-0::before {
+  content: "\f244"; }
+
+.fa-socks::before {
+  content: "\f696"; }
+
+.fa-inbox::before {
+  content: "\f01c"; }
+
+.fa-section::before {
+  content: "\e447"; }
+
+.fa-gauge-high::before {
+  content: "\f625"; }
+
+.fa-tachometer-alt::before {
+  content: "\f625"; }
+
+.fa-tachometer-alt-fast::before {
+  content: "\f625"; }
+
+.fa-envelope-open-text::before {
+  content: "\f658"; }
+
+.fa-hospital::before {
+  content: "\f0f8"; }
+
+.fa-hospital-alt::before {
+  content: "\f0f8"; }
+
+.fa-hospital-wide::before {
+  content: "\f0f8"; }
+
+.fa-wine-bottle::before {
+  content: "\f72f"; }
+
+.fa-chess-rook::before {
+  content: "\f447"; }
+
+.fa-bars-staggered::before {
+  content: "\f550"; }
+
+.fa-reorder::before {
+  content: "\f550"; }
+
+.fa-stream::before {
+  content: "\f550"; }
+
+.fa-dharmachakra::before {
+  content: "\f655"; }
+
+.fa-hotdog::before {
+  content: "\f80f"; }
+
+.fa-person-walking-with-cane::before {
+  content: "\f29d"; }
+
+.fa-blind::before {
+  content: "\f29d"; }
+
+.fa-drum::before {
+  content: "\f569"; }
+
+.fa-ice-cream::before {
+  content: "\f810"; }
+
+.fa-heart-circle-bolt::before {
+  content: "\e4fc"; }
+
+.fa-fax::before {
+  content: "\f1ac"; }
+
+.fa-paragraph::before {
+  content: "\f1dd"; }
+
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+  content: "\f772"; }
+
+.fa-vote-yea::before {
+  content: "\f772"; }
+
+.fa-star-half::before {
+  content: "\f089"; }
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+.fa-boxes-stacked::before {
+  content: "\f468"; }
+
+.fa-boxes::before {
+  content: "\f468"; }
+
+.fa-boxes-alt::before {
+  content: "\f468"; }
+
+.fa-link::before {
+  content: "\f0c1"; }
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+.fa-chain::before {
+  content: "\f0c1"; }
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+.fa-ear-listen::before {
+  content: "\f2a2"; }
+
+.fa-assistive-listening-systems::before {
+  content: "\f2a2"; }
+
+.fa-tree-city::before {
+  content: "\e587"; }
+
+.fa-play::before {
+  content: "\f04b"; }
+
+.fa-font::before {
+  content: "\f031"; }
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+.fa-rupiah-sign::before {
+  content: "\e23d"; }
+
+.fa-magnifying-glass::before {
+  content: "\f002"; }
+
+.fa-search::before {
+  content: "\f002"; }
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+.fa-table-tennis-paddle-ball::before {
+  content: "\f45d"; }
+
+.fa-ping-pong-paddle-ball::before {
+  content: "\f45d"; }
+
+.fa-table-tennis::before {
+  content: "\f45d"; }
+
+.fa-person-dots-from-line::before {
+  content: "\f470"; }
+
+.fa-diagnoses::before {
+  content: "\f470"; }
+
+.fa-trash-can-arrow-up::before {
+  content: "\f82a"; }
+
+.fa-trash-restore-alt::before {
+  content: "\f82a"; }
+
+.fa-naira-sign::before {
+  content: "\e1f6"; }
+
+.fa-cart-arrow-down::before {
+  content: "\f218"; }
+
+.fa-walkie-talkie::before {
+  content: "\f8ef"; }
+
+.fa-file-pen::before {
+  content: "\f31c"; }
+
+.fa-file-edit::before {
+  content: "\f31c"; }
+
+.fa-receipt::before {
+  content: "\f543"; }
+
+.fa-square-pen::before {
+  content: "\f14b"; }
+
+.fa-pen-square::before {
+  content: "\f14b"; }
+
+.fa-pencil-square::before {
+  content: "\f14b"; }
+
+.fa-suitcase-rolling::before {
+  content: "\f5c1"; }
+
+.fa-person-circle-exclamation::before {
+  content: "\e53f"; }
+
+.fa-chevron-down::before {
+  content: "\f078"; }
+
+.fa-battery-full::before {
+  content: "\f240"; }
+
+.fa-battery::before {
+  content: "\f240"; }
+
+.fa-battery-5::before {
+  content: "\f240"; }
+
+.fa-skull-crossbones::before {
+  content: "\f714"; }
+
+.fa-code-compare::before {
+  content: "\e13a"; }
+
+.fa-list-ul::before {
+  content: "\f0ca"; }
+
+.fa-list-dots::before {
+  content: "\f0ca"; }
+
+.fa-school-lock::before {
+  content: "\e56f"; }
+
+.fa-tower-cell::before {
+  content: "\e585"; }
+
+.fa-down-long::before {
+  content: "\f309"; }
+
+.fa-long-arrow-alt-down::before {
+  content: "\f309"; }
+
+.fa-ranking-star::before {
+  content: "\e561"; }
+
+.fa-chess-king::before {
+  content: "\f43f"; }
+
+.fa-person-harassing::before {
+  content: "\e549"; }
+
+.fa-brazilian-real-sign::before {
+  content: "\e46c"; }
+
+.fa-landmark-dome::before {
+  content: "\f752"; }
+
+.fa-landmark-alt::before {
+  content: "\f752"; }
+
+.fa-arrow-up::before {
+  content: "\f062"; }
+
+.fa-tv::before {
+  content: "\f26c"; }
+
+.fa-television::before {
+  content: "\f26c"; }
+
+.fa-tv-alt::before {
+  content: "\f26c"; }
+
+.fa-shrimp::before {
+  content: "\e448"; }
+
+.fa-list-check::before {
+  content: "\f0ae"; }
+
+.fa-tasks::before {
+  content: "\f0ae"; }
+
+.fa-jug-detergent::before {
+  content: "\e519"; }
+
+.fa-circle-user::before {
+  content: "\f2bd"; }
+
+.fa-user-circle::before {
+  content: "\f2bd"; }
+
+.fa-user-shield::before {
+  content: "\f505"; }
+
+.fa-wind::before {
+  content: "\f72e"; }
+
+.fa-car-burst::before {
+  content: "\f5e1"; }
+
+.fa-car-crash::before {
+  content: "\f5e1"; }
+
+.fa-y::before {
+  content: "\59"; }
+
+.fa-person-snowboarding::before {
+  content: "\f7ce"; }
+
+.fa-snowboarding::before {
+  content: "\f7ce"; }
+
+.fa-truck-fast::before {
+  content: "\f48b"; }
+
+.fa-shipping-fast::before {
+  content: "\f48b"; }
+
+.fa-fish::before {
+  content: "\f578"; }
+
+.fa-user-graduate::before {
+  content: "\f501"; }
+
+.fa-circle-half-stroke::before {
+  content: "\f042"; }
+
+.fa-adjust::before {
+  content: "\f042"; }
+
+.fa-clapperboard::before {
+  content: "\e131"; }
+
+.fa-circle-radiation::before {
+  content: "\f7ba"; }
+
+.fa-radiation-alt::before {
+  content: "\f7ba"; }
+
+.fa-baseball::before {
+  content: "\f433"; }
+
+.fa-baseball-ball::before {
+  content: "\f433"; }
+
+.fa-jet-fighter-up::before {
+  content: "\e518"; }
+
+.fa-diagram-project::before {
+  content: "\f542"; }
+
+.fa-project-diagram::before {
+  content: "\f542"; }
+
+.fa-copy::before {
+  content: "\f0c5"; }
+
+.fa-volume-xmark::before {
+  content: "\f6a9"; }
+
+.fa-volume-mute::before {
+  content: "\f6a9"; }
+
+.fa-volume-times::before {
+  content: "\f6a9"; }
+
+.fa-hand-sparkles::before {
+  content: "\e05d"; }
+
+.fa-grip::before {
+  content: "\f58d"; }
+
+.fa-grip-horizontal::before {
+  content: "\f58d"; }
+
+.fa-share-from-square::before {
+  content: "\f14d"; }
+
+.fa-share-square::before {
+  content: "\f14d"; }
+
+.fa-child-combatant::before {
+  content: "\e4e0"; }
+
+.fa-child-rifle::before {
+  content: "\e4e0"; }
+
+.fa-gun::before {
+  content: "\e19b"; }
+
+.fa-square-phone::before {
+  content: "\f098"; }
+
+.fa-phone-square::before {
+  content: "\f098"; }
+
+.fa-plus::before {
+  content: "\2b"; }
+
+.fa-add::before {
+  content: "\2b"; }
+
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+  content: "\f065"; }
+
+.fa-computer::before {
+  content: "\e4e5"; }
+
+.fa-xmark::before {
+  content: "\f00d"; }
+
+.fa-close::before {
+  content: "\f00d"; }
+
+.fa-multiply::before {
+  content: "\f00d"; }
+
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+  content: "\f00d"; }
+
+.fa-times::before {
+  content: "\f00d"; }
+
+.fa-arrows-up-down-left-right::before {
+  content: "\f047"; }
+
+.fa-arrows::before {
+  content: "\f047"; }
+
+.fa-chalkboard-user::before {
+  content: "\f51c"; }
+
+.fa-chalkboard-teacher::before {
+  content: "\f51c"; }
+
+.fa-peso-sign::before {
+  content: "\e222"; }
+
+.fa-building-shield::before {
+  content: "\e4d8"; }
+
+.fa-baby::before {
+  content: "\f77c"; }
+
+.fa-users-line::before {
+  content: "\e592"; }
+
+.fa-quote-left::before {
+  content: "\f10d"; }
+
+.fa-quote-left-alt::before {
+  content: "\f10d"; }
+
+.fa-tractor::before {
+  content: "\f722"; }
+
+.fa-trash-arrow-up::before {
+  content: "\f829"; }
+
+.fa-trash-restore::before {
+  content: "\f829"; }
+
+.fa-arrow-down-up-lock::before {
+  content: "\e4b0"; }
+
+.fa-lines-leaning::before {
+  content: "\e51e"; }
+
+.fa-ruler-combined::before {
+  content: "\f546"; }
+
+.fa-copyright::before {
+  content: "\f1f9"; }
+
+.fa-equals::before {
+  content: "\3d"; }
+
+.fa-blender::before {
+  content: "\f517"; }
+
+.fa-teeth::before {
+  content: "\f62e"; }
+
+.fa-shekel-sign::before {
+  content: "\f20b"; }
+
+.fa-ils::before {
+  content: "\f20b"; }
+
+.fa-shekel::before {
+  content: "\f20b"; }
+
+.fa-sheqel::before {
+  content: "\f20b"; }
+
+.fa-sheqel-sign::before {
+  content: "\f20b"; }
+
+.fa-map::before {
+  content: "\f279"; }
+
+.fa-rocket::before {
+  content: "\f135"; }
+
+.fa-photo-film::before {
+  content: "\f87c"; }
+
+.fa-photo-video::before {
+  content: "\f87c"; }
+
+.fa-folder-minus::before {
+  content: "\f65d"; }
+
+.fa-store::before {
+  content: "\f54e"; }
+
+.fa-arrow-trend-up::before {
+  content: "\e098"; }
+
+.fa-plug-circle-minus::before {
+  content: "\e55e"; }
+
+.fa-sign-hanging::before {
+  content: "\f4d9"; }
+
+.fa-sign::before {
+  content: "\f4d9"; }
+
+.fa-bezier-curve::before {
+  content: "\f55b"; }
+
+.fa-bell-slash::before {
+  content: "\f1f6"; }
+
+.fa-tablet::before {
+  content: "\f3fb"; }
+
+.fa-tablet-android::before {
+  content: "\f3fb"; }
+
+.fa-school-flag::before {
+  content: "\e56e"; }
+
+.fa-fill::before {
+  content: "\f575"; }
+
+.fa-angle-up::before {
+  content: "\f106"; }
+
+.fa-drumstick-bite::before {
+  content: "\f6d7"; }
+
+.fa-holly-berry::before {
+  content: "\f7aa"; }
+
+.fa-chevron-left::before {
+  content: "\f053"; }
+
+.fa-bacteria::before {
+  content: "\e059"; }
+
+.fa-hand-lizard::before {
+  content: "\f258"; }
+
+.fa-notdef::before {
+  content: "\e1fe"; }
+
+.fa-disease::before {
+  content: "\f7fa"; }
+
+.fa-briefcase-medical::before {
+  content: "\f469"; }
+
+.fa-genderless::before {
+  content: "\f22d"; }
+
+.fa-chevron-right::before {
+  content: "\f054"; }
+
+.fa-retweet::before {
+  content: "\f079"; }
+
+.fa-car-rear::before {
+  content: "\f5de"; }
+
+.fa-car-alt::before {
+  content: "\f5de"; }
+
+.fa-pump-soap::before {
+  content: "\e06b"; }
+
+.fa-video-slash::before {
+  content: "\f4e2"; }
+
+.fa-battery-quarter::before {
+  content: "\f243"; }
+
+.fa-battery-2::before {
+  content: "\f243"; }
+
+.fa-radio::before {
+  content: "\f8d7"; }
+
+.fa-baby-carriage::before {
+  content: "\f77d"; }
+
+.fa-carriage-baby::before {
+  content: "\f77d"; }
+
+.fa-traffic-light::before {
+  content: "\f637"; }
+
+.fa-thermometer::before {
+  content: "\f491"; }
+
+.fa-vr-cardboard::before {
+  content: "\f729"; }
+
+.fa-hand-middle-finger::before {
+  content: "\f806"; }
+
+.fa-percent::before {
+  content: "\25"; }
+
+.fa-percentage::before {
+  content: "\25"; }
+
+.fa-truck-moving::before {
+  content: "\f4df"; }
+
+.fa-glass-water-droplet::before {
+  content: "\e4f5"; }
+
+.fa-display::before {
+  content: "\e163"; }
+
+.fa-face-smile::before {
+  content: "\f118"; }
+
+.fa-smile::before {
+  content: "\f118"; }
+
+.fa-thumbtack::before {
+  content: "\f08d"; }
+
+.fa-thumb-tack::before {
+  content: "\f08d"; }
+
+.fa-trophy::before {
+  content: "\f091"; }
+
+.fa-person-praying::before {
+  content: "\f683"; }
+
+.fa-pray::before {
+  content: "\f683"; }
+
+.fa-hammer::before {
+  content: "\f6e3"; }
+
+.fa-hand-peace::before {
+  content: "\f25b"; }
+
+.fa-rotate::before {
+  content: "\f2f1"; }
+
+.fa-sync-alt::before {
+  content: "\f2f1"; }
+
+.fa-spinner::before {
+  content: "\f110"; }
+
+.fa-robot::before {
+  content: "\f544"; }
+
+.fa-peace::before {
+  content: "\f67c"; }
+
+.fa-gears::before {
+  content: "\f085"; }
+
+.fa-cogs::before {
+  content: "\f085"; }
+
+.fa-warehouse::before {
+  content: "\f494"; }
+
+.fa-arrow-up-right-dots::before {
+  content: "\e4b7"; }
+
+.fa-splotch::before {
+  content: "\f5bc"; }
+
+.fa-face-grin-hearts::before {
+  content: "\f584"; }
+
+.fa-grin-hearts::before {
+  content: "\f584"; }
+
+.fa-dice-four::before {
+  content: "\f524"; }
+
+.fa-sim-card::before {
+  content: "\f7c4"; }
+
+.fa-transgender::before {
+  content: "\f225"; }
+
+.fa-transgender-alt::before {
+  content: "\f225"; }
+
+.fa-mercury::before {
+  content: "\f223"; }
+
+.fa-arrow-turn-down::before {
+  content: "\f149"; }
+
+.fa-level-down::before {
+  content: "\f149"; }
+
+.fa-person-falling-burst::before {
+  content: "\e547"; }
+
+.fa-award::before {
+  content: "\f559"; }
+
+.fa-ticket-simple::before {
+  content: "\f3ff"; }
+
+.fa-ticket-alt::before {
+  content: "\f3ff"; }
+
+.fa-building::before {
+  content: "\f1ad"; }
+
+.fa-angles-left::before {
+  content: "\f100"; }
+
+.fa-angle-double-left::before {
+  content: "\f100"; }
+
+.fa-qrcode::before {
+  content: "\f029"; }
+
+.fa-clock-rotate-left::before {
+  content: "\f1da"; }
+
+.fa-history::before {
+  content: "\f1da"; }
+
+.fa-face-grin-beam-sweat::before {
+  content: "\f583"; }
+
+.fa-grin-beam-sweat::before {
+  content: "\f583"; }
+
+.fa-file-export::before {
+  content: "\f56e"; }
+
+.fa-arrow-right-from-file::before {
+  content: "\f56e"; }
+
+.fa-shield::before {
+  content: "\f132"; }
+
+.fa-shield-blank::before {
+  content: "\f132"; }
+
+.fa-arrow-up-short-wide::before {
+  content: "\f885"; }
+
+.fa-sort-amount-up-alt::before {
+  content: "\f885"; }
+
+.fa-house-medical::before {
+  content: "\e3b2"; }
+
+.fa-golf-ball-tee::before {
+  content: "\f450"; }
+
+.fa-golf-ball::before {
+  content: "\f450"; }
+
+.fa-circle-chevron-left::before {
+  content: "\f137"; }
+
+.fa-chevron-circle-left::before {
+  content: "\f137"; }
+
+.fa-house-chimney-window::before {
+  content: "\e00d"; }
+
+.fa-pen-nib::before {
+  content: "\f5ad"; }
+
+.fa-tent-arrow-turn-left::before {
+  content: "\e580"; }
+
+.fa-tents::before {
+  content: "\e582"; }
+
+.fa-wand-magic::before {
+  content: "\f0d0"; }
+
+.fa-magic::before {
+  content: "\f0d0"; }
+
+.fa-dog::before {
+  content: "\f6d3"; }
+
+.fa-carrot::before {
+  content: "\f787"; }
+
+.fa-moon::before {
+  content: "\f186"; }
+
+.fa-wine-glass-empty::before {
+  content: "\f5ce"; }
+
+.fa-wine-glass-alt::before {
+  content: "\f5ce"; }
+
+.fa-cheese::before {
+  content: "\f7ef"; }
+
+.fa-yin-yang::before {
+  content: "\f6ad"; }
+
+.fa-music::before {
+  content: "\f001"; }
+
+.fa-code-commit::before {
+  content: "\f386"; }
+
+.fa-temperature-low::before {
+  content: "\f76b"; }
+
+.fa-person-biking::before {
+  content: "\f84a"; }
+
+.fa-biking::before {
+  content: "\f84a"; }
+
+.fa-broom::before {
+  content: "\f51a"; }
+
+.fa-shield-heart::before {
+  content: "\e574"; }
+
+.fa-gopuram::before {
+  content: "\f664"; }
+
+.fa-earth-oceania::before {
+  content: "\e47b"; }
+
+.fa-globe-oceania::before {
+  content: "\e47b"; }
+
+.fa-square-xmark::before {
+  content: "\f2d3"; }
+
+.fa-times-square::before {
+  content: "\f2d3"; }
+
+.fa-xmark-square::before {
+  content: "\f2d3"; }
+
+.fa-hashtag::before {
+  content: "\23"; }
+
+.fa-up-right-and-down-left-from-center::before {
+  content: "\f424"; }
+
+.fa-expand-alt::before {
+  content: "\f424"; }
+
+.fa-oil-can::before {
+  content: "\f613"; }
+
+.fa-t::before {
+  content: "\54"; }
+
+.fa-hippo::before {
+  content: "\f6ed"; }
+
+.fa-chart-column::before {
+  content: "\e0e3"; }
+
+.fa-infinity::before {
+  content: "\f534"; }
+
+.fa-vial-circle-check::before {
+  content: "\e596"; }
+
+.fa-person-arrow-down-to-line::before {
+  content: "\e538"; }
+
+.fa-voicemail::before {
+  content: "\f897"; }
+
+.fa-fan::before {
+  content: "\f863"; }
+
+.fa-person-walking-luggage::before {
+  content: "\e554"; }
+
+.fa-up-down::before {
+  content: "\f338"; }
+
+.fa-arrows-alt-v::before {
+  content: "\f338"; }
+
+.fa-cloud-moon-rain::before {
+  content: "\f73c"; }
+
+.fa-calendar::before {
+  content: "\f133"; }
+
+.fa-trailer::before {
+  content: "\e041"; }
+
+.fa-bahai::before {
+  content: "\f666"; }
+
+.fa-haykal::before {
+  content: "\f666"; }
+
+.fa-sd-card::before {
+  content: "\f7c2"; }
+
+.fa-dragon::before {
+  content: "\f6d5"; }
+
+.fa-shoe-prints::before {
+  content: "\f54b"; }
+
+.fa-circle-plus::before {
+  content: "\f055"; }
+
+.fa-plus-circle::before {
+  content: "\f055"; }
+
+.fa-face-grin-tongue-wink::before {
+  content: "\f58b"; }
+
+.fa-grin-tongue-wink::before {
+  content: "\f58b"; }
+
+.fa-hand-holding::before {
+  content: "\f4bd"; }
+
+.fa-plug-circle-exclamation::before {
+  content: "\e55d"; }
+
+.fa-link-slash::before {
+  content: "\f127"; }
+
+.fa-chain-broken::before {
+  content: "\f127"; }
+
+.fa-chain-slash::before {
+  content: "\f127"; }
+
+.fa-unlink::before {
+  content: "\f127"; }
+
+.fa-clone::before {
+  content: "\f24d"; }
+
+.fa-person-walking-arrow-loop-left::before {
+  content: "\e551"; }
+
+.fa-arrow-up-z-a::before {
+  content: "\f882"; }
+
+.fa-sort-alpha-up-alt::before {
+  content: "\f882"; }
+
+.fa-fire-flame-curved::before {
+  content: "\f7e4"; }
+
+.fa-fire-alt::before {
+  content: "\f7e4"; }
+
+.fa-tornado::before {
+  content: "\f76f"; }
+
+.fa-file-circle-plus::before {
+  content: "\e494"; }
+
+.fa-book-quran::before {
+  content: "\f687"; }
+
+.fa-quran::before {
+  content: "\f687"; }
+
+.fa-anchor::before {
+  content: "\f13d"; }
+
+.fa-border-all::before {
+  content: "\f84c"; }
+
+.fa-face-angry::before {
+  content: "\f556"; }
+
+.fa-angry::before {
+  content: "\f556"; }
+
+.fa-cookie-bite::before {
+  content: "\f564"; }
+
+.fa-arrow-trend-down::before {
+  content: "\e097"; }
+
+.fa-rss::before {
+  content: "\f09e"; }
+
+.fa-feed::before {
+  content: "\f09e"; }
+
+.fa-draw-polygon::before {
+  content: "\f5ee"; }
+
+.fa-scale-balanced::before {
+  content: "\f24e"; }
+
+.fa-balance-scale::before {
+  content: "\f24e"; }
+
+.fa-gauge-simple-high::before {
+  content: "\f62a"; }
+
+.fa-tachometer::before {
+  content: "\f62a"; }
+
+.fa-tachometer-fast::before {
+  content: "\f62a"; }
+
+.fa-shower::before {
+  content: "\f2cc"; }
+
+.fa-desktop::before {
+  content: "\f390"; }
+
+.fa-desktop-alt::before {
+  content: "\f390"; }
+
+.fa-m::before {
+  content: "\4d"; }
+
+.fa-table-list::before {
+  content: "\f00b"; }
+
+.fa-th-list::before {
+  content: "\f00b"; }
+
+.fa-comment-sms::before {
+  content: "\f7cd"; }
+
+.fa-sms::before {
+  content: "\f7cd"; }
+
+.fa-book::before {
+  content: "\f02d"; }
+
+.fa-user-plus::before {
+  content: "\f234"; }
+
+.fa-check::before {
+  content: "\f00c"; }
+
+.fa-battery-three-quarters::before {
+  content: "\f241"; }
+
+.fa-battery-4::before {
+  content: "\f241"; }
+
+.fa-house-circle-check::before {
+  content: "\e509"; }
+
+.fa-angle-left::before {
+  content: "\f104"; }
+
+.fa-diagram-successor::before {
+  content: "\e47a"; }
+
+.fa-truck-arrow-right::before {
+  content: "\e58b"; }
+
+.fa-arrows-split-up-and-left::before {
+  content: "\e4bc"; }
+
+.fa-hand-fist::before {
+  content: "\f6de"; }
+
+.fa-fist-raised::before {
+  content: "\f6de"; }
+
+.fa-cloud-moon::before {
+  content: "\f6c3"; }
+
+.fa-briefcase::before {
+  content: "\f0b1"; }
+
+.fa-person-falling::before {
+  content: "\e546"; }
+
+.fa-image-portrait::before {
+  content: "\f3e0"; }
+
+.fa-portrait::before {
+  content: "\f3e0"; }
+
+.fa-user-tag::before {
+  content: "\f507"; }
+
+.fa-rug::before {
+  content: "\e569"; }
+
+.fa-earth-europe::before {
+  content: "\f7a2"; }
+
+.fa-globe-europe::before {
+  content: "\f7a2"; }
+
+.fa-cart-flatbed-suitcase::before {
+  content: "\f59d"; }
+
+.fa-luggage-cart::before {
+  content: "\f59d"; }
+
+.fa-rectangle-xmark::before {
+  content: "\f410"; }
+
+.fa-rectangle-times::before {
+  content: "\f410"; }
+
+.fa-times-rectangle::before {
+  content: "\f410"; }
+
+.fa-window-close::before {
+  content: "\f410"; }
+
+.fa-baht-sign::before {
+  content: "\e0ac"; }
+
+.fa-book-open::before {
+  content: "\f518"; }
+
+.fa-book-journal-whills::before {
+  content: "\f66a"; }
+
+.fa-journal-whills::before {
+  content: "\f66a"; }
+
+.fa-handcuffs::before {
+  content: "\e4f8"; }
+
+.fa-triangle-exclamation::before {
+  content: "\f071"; }
+
+.fa-exclamation-triangle::before {
+  content: "\f071"; }
+
+.fa-warning::before {
+  content: "\f071"; }
+
+.fa-database::before {
+  content: "\f1c0"; }
+
+.fa-share::before {
+  content: "\f064"; }
+
+.fa-arrow-turn-right::before {
+  content: "\f064"; }
+
+.fa-mail-forward::before {
+  content: "\f064"; }
+
+.fa-bottle-droplet::before {
+  content: "\e4c4"; }
+
+.fa-mask-face::before {
+  content: "\e1d7"; }
+
+.fa-hill-rockslide::before {
+  content: "\e508"; }
+
+.fa-right-left::before {
+  content: "\f362"; }
+
+.fa-exchange-alt::before {
+  content: "\f362"; }
+
+.fa-paper-plane::before {
+  content: "\f1d8"; }
+
+.fa-road-circle-exclamation::before {
+  content: "\e565"; }
+
+.fa-dungeon::before {
+  content: "\f6d9"; }
+
+.fa-align-right::before {
+  content: "\f038"; }
+
+.fa-money-bill-1-wave::before {
+  content: "\f53b"; }
+
+.fa-money-bill-wave-alt::before {
+  content: "\f53b"; }
+
+.fa-life-ring::before {
+  content: "\f1cd"; }
+
+.fa-hands::before {
+  content: "\f2a7"; }
+
+.fa-sign-language::before {
+  content: "\f2a7"; }
+
+.fa-signing::before {
+  content: "\f2a7"; }
+
+.fa-calendar-day::before {
+  content: "\f783"; }
+
+.fa-water-ladder::before {
+  content: "\f5c5"; }
+
+.fa-ladder-water::before {
+  content: "\f5c5"; }
+
+.fa-swimming-pool::before {
+  content: "\f5c5"; }
+
+.fa-arrows-up-down::before {
+  content: "\f07d"; }
+
+.fa-arrows-v::before {
+  content: "\f07d"; }
+
+.fa-face-grimace::before {
+  content: "\f57f"; }
+
+.fa-grimace::before {
+  content: "\f57f"; }
+
+.fa-wheelchair-move::before {
+  content: "\e2ce"; }
+
+.fa-wheelchair-alt::before {
+  content: "\e2ce"; }
+
+.fa-turn-down::before {
+  content: "\f3be"; }
+
+.fa-level-down-alt::before {
+  content: "\f3be"; }
+
+.fa-person-walking-arrow-right::before {
+  content: "\e552"; }
+
+.fa-square-envelope::before {
+  content: "\f199"; }
+
+.fa-envelope-square::before {
+  content: "\f199"; }
+
+.fa-dice::before {
+  content: "\f522"; }
+
+.fa-bowling-ball::before {
+  content: "\f436"; }
+
+.fa-brain::before {
+  content: "\f5dc"; }
+
+.fa-bandage::before {
+  content: "\f462"; }
+
+.fa-band-aid::before {
+  content: "\f462"; }
+
+.fa-calendar-minus::before {
+  content: "\f272"; }
+
+.fa-circle-xmark::before {
+  content: "\f057"; }
+
+.fa-times-circle::before {
+  content: "\f057"; }
+
+.fa-xmark-circle::before {
+  content: "\f057"; }
+
+.fa-gifts::before {
+  content: "\f79c"; }
+
+.fa-hotel::before {
+  content: "\f594"; }
+
+.fa-earth-asia::before {
+  content: "\f57e"; }
+
+.fa-globe-asia::before {
+  content: "\f57e"; }
+
+.fa-id-card-clip::before {
+  content: "\f47f"; }
+
+.fa-id-card-alt::before {
+  content: "\f47f"; }
+
+.fa-magnifying-glass-plus::before {
+  content: "\f00e"; }
+
+.fa-search-plus::before {
+  content: "\f00e"; }
+
+.fa-thumbs-up::before {
+  content: "\f164"; }
+
+.fa-user-clock::before {
+  content: "\f4fd"; }
+
+.fa-hand-dots::before {
+  content: "\f461"; }
+
+.fa-allergies::before {
+  content: "\f461"; }
+
+.fa-file-invoice::before {
+  content: "\f570"; }
+
+.fa-window-minimize::before {
+  content: "\f2d1"; }
+
+.fa-mug-saucer::before {
+  content: "\f0f4"; }
+
+.fa-coffee::before {
+  content: "\f0f4"; }
+
+.fa-brush::before {
+  content: "\f55d"; }
+
+.fa-mask::before {
+  content: "\f6fa"; }
+
+.fa-magnifying-glass-minus::before {
+  content: "\f010"; }
+
+.fa-search-minus::before {
+  content: "\f010"; }
+
+.fa-ruler-vertical::before {
+  content: "\f548"; }
+
+.fa-user-large::before {
+  content: "\f406"; }
+
+.fa-user-alt::before {
+  content: "\f406"; }
+
+.fa-train-tram::before {
+  content: "\e5b4"; }
+
+.fa-user-nurse::before {
+  content: "\f82f"; }
+
+.fa-syringe::before {
+  content: "\f48e"; }
+
+.fa-cloud-sun::before {
+  content: "\f6c4"; }
+
+.fa-stopwatch-20::before {
+  content: "\e06f"; }
+
+.fa-square-full::before {
+  content: "\f45c"; }
+
+.fa-magnet::before {
+  content: "\f076"; }
+
+.fa-jar::before {
+  content: "\e516"; }
+
+.fa-note-sticky::before {
+  content: "\f249"; }
+
+.fa-sticky-note::before {
+  content: "\f249"; }
+
+.fa-bug-slash::before {
+  content: "\e490"; }
+
+.fa-arrow-up-from-water-pump::before {
+  content: "\e4b6"; }
+
+.fa-bone::before {
+  content: "\f5d7"; }
+
+.fa-user-injured::before {
+  content: "\f728"; }
+
+.fa-face-sad-tear::before {
+  content: "\f5b4"; }
+
+.fa-sad-tear::before {
+  content: "\f5b4"; }
+
+.fa-plane::before {
+  content: "\f072"; }
+
+.fa-tent-arrows-down::before {
+  content: "\e581"; }
+
+.fa-exclamation::before {
+  content: "\21"; }
+
+.fa-arrows-spin::before {
+  content: "\e4bb"; }
+
+.fa-print::before {
+  content: "\f02f"; }
+
+.fa-turkish-lira-sign::before {
+  content: "\e2bb"; }
+
+.fa-try::before {
+  content: "\e2bb"; }
+
+.fa-turkish-lira::before {
+  content: "\e2bb"; }
+
+.fa-dollar-sign::before {
+  content: "\24"; }
+
+.fa-dollar::before {
+  content: "\24"; }
+
+.fa-usd::before {
+  content: "\24"; }
+
+.fa-x::before {
+  content: "\58"; }
+
+.fa-magnifying-glass-dollar::before {
+  content: "\f688"; }
+
+.fa-search-dollar::before {
+  content: "\f688"; }
+
+.fa-users-gear::before {
+  content: "\f509"; }
+
+.fa-users-cog::before {
+  content: "\f509"; }
+
+.fa-person-military-pointing::before {
+  content: "\e54a"; }
+
+.fa-building-columns::before {
+  content: "\f19c"; }
+
+.fa-bank::before {
+  content: "\f19c"; }
+
+.fa-institution::before {
+  content: "\f19c"; }
+
+.fa-museum::before {
+  content: "\f19c"; }
+
+.fa-university::before {
+  content: "\f19c"; }
+
+.fa-umbrella::before {
+  content: "\f0e9"; }
+
+.fa-trowel::before {
+  content: "\e589"; }
+
+.fa-d::before {
+  content: "\44"; }
+
+.fa-stapler::before {
+  content: "\e5af"; }
+
+.fa-masks-theater::before {
+  content: "\f630"; }
+
+.fa-theater-masks::before {
+  content: "\f630"; }
+
+.fa-kip-sign::before {
+  content: "\e1c4"; }
+
+.fa-hand-point-left::before {
+  content: "\f0a5"; }
+
+.fa-handshake-simple::before {
+  content: "\f4c6"; }
+
+.fa-handshake-alt::before {
+  content: "\f4c6"; }
+
+.fa-jet-fighter::before {
+  content: "\f0fb"; }
+
+.fa-fighter-jet::before {
+  content: "\f0fb"; }
+
+.fa-square-share-nodes::before {
+  content: "\f1e1"; }
+
+.fa-share-alt-square::before {
+  content: "\f1e1"; }
+
+.fa-barcode::before {
+  content: "\f02a"; }
+
+.fa-plus-minus::before {
+  content: "\e43c"; }
+
+.fa-video::before {
+  content: "\f03d"; }
+
+.fa-video-camera::before {
+  content: "\f03d"; }
+
+.fa-graduation-cap::before {
+  content: "\f19d"; }
+
+.fa-mortar-board::before {
+  content: "\f19d"; }
+
+.fa-hand-holding-medical::before {
+  content: "\e05c"; }
+
+.fa-person-circle-check::before {
+  content: "\e53e"; }
+
+.fa-turn-up::before {
+  content: "\f3bf"; }
+
+.fa-level-up-alt::before {
+  content: "\f3bf"; }
+
+.sr-only,
+.fa-sr-only {
+  position: absolute;
+  width: 1px;
+  height: 1px;
+  padding: 0;
+  margin: -1px;
+  overflow: hidden;
+  clip: rect(0, 0, 0, 0);
+  white-space: nowrap;
+  border-width: 0; }
+
+.sr-only-focusable:not(:focus),
+.fa-sr-only-focusable:not(:focus) {
+  position: absolute;
+  width: 1px;
+  height: 1px;
+  padding: 0;
+  margin: -1px;
+  overflow: hidden;
+  clip: rect(0, 0, 0, 0);
+  white-space: nowrap;
+  border-width: 0; }
+:root, :host {
+  --fa-style-family-brands: 'Font Awesome 6 Brands';
+  --fa-font-brands: normal 400 1em/1 'Font Awesome 6 Brands'; }
+
+@font-face {
+  font-family: 'Font Awesome 6 Brands';
+  font-style: normal;
+  font-weight: 400;
+  font-display: block;
+  src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); }
+
+.fab,
+.fa-brands {
+  font-weight: 400; }
+
+.fa-monero:before {
+  content: "\f3d0"; }
+
+.fa-hooli:before {
+  content: "\f427"; }
+
+.fa-yelp:before {
+  content: "\f1e9"; }
+
+.fa-cc-visa:before {
+  content: "\f1f0"; }
+
+.fa-lastfm:before {
+  content: "\f202"; }
+
+.fa-shopware:before {
+  content: "\f5b5"; }
+
+.fa-creative-commons-nc:before {
+  content: "\f4e8"; }
+
+.fa-aws:before {
+  content: "\f375"; }
+
+.fa-redhat:before {
+  content: "\f7bc"; }
+
+.fa-yoast:before {
+  content: "\f2b1"; }
+
+.fa-cloudflare:before {
+  content: "\e07d"; }
+
+.fa-ups:before {
+  content: "\f7e0"; }
+
+.fa-wpexplorer:before {
+  content: "\f2de"; }
+
+.fa-dyalog:before {
+  content: "\f399"; }
+
+.fa-bity:before {
+  content: "\f37a"; }
+
+.fa-stackpath:before {
+  content: "\f842"; }
+
+.fa-buysellads:before {
+  content: "\f20d"; }
+
+.fa-first-order:before {
+  content: "\f2b0"; }
+
+.fa-modx:before {
+  content: "\f285"; }
+
+.fa-guilded:before {
+  content: "\e07e"; }
+
+.fa-vnv:before {
+  content: "\f40b"; }
+
+.fa-square-js:before {
+  content: "\f3b9"; }
+
+.fa-js-square:before {
+  content: "\f3b9"; }
+
+.fa-microsoft:before {
+  content: "\f3ca"; }
+
+.fa-qq:before {
+  content: "\f1d6"; }
+
+.fa-orcid:before {
+  content: "\f8d2"; }
+
+.fa-java:before {
+  content: "\f4e4"; }
+
+.fa-invision:before {
+  content: "\f7b0"; }
+
+.fa-creative-commons-pd-alt:before {
+  content: "\f4ed"; }
+
+.fa-centercode:before {
+  content: "\f380"; }
+
+.fa-glide-g:before {
+  content: "\f2a6"; }
+
+.fa-drupal:before {
+  content: "\f1a9"; }
+
+.fa-hire-a-helper:before {
+  content: "\f3b0"; }
+
+.fa-creative-commons-by:before {
+  content: "\f4e7"; }
+
+.fa-unity:before {
+  content: "\e049"; }
+
+.fa-whmcs:before {
+  content: "\f40d"; }
+
+.fa-rocketchat:before {
+  content: "\f3e8"; }
+
+.fa-vk:before {
+  content: "\f189"; }
+
+.fa-untappd:before {
+  content: "\f405"; }
+
+.fa-mailchimp:before {
+  content: "\f59e"; }
+
+.fa-css3-alt:before {
+  content: "\f38b"; }
+
+.fa-square-reddit:before {
+  content: "\f1a2"; }
+
+.fa-reddit-square:before {
+  content: "\f1a2"; }
+
+.fa-vimeo-v:before {
+  content: "\f27d"; }
+
+.fa-contao:before {
+  content: "\f26d"; }
+
+.fa-square-font-awesome:before {
+  content: "\e5ad"; }
+
+.fa-deskpro:before {
+  content: "\f38f"; }
+
+.fa-sistrix:before {
+  content: "\f3ee"; }
+
+.fa-square-instagram:before {
+  content: "\e055"; }
+
+.fa-instagram-square:before {
+  content: "\e055"; }
+
+.fa-battle-net:before {
+  content: "\f835"; }
+
+.fa-the-red-yeti:before {
+  content: "\f69d"; }
+
+.fa-square-hacker-news:before {
+  content: "\f3af"; }
+
+.fa-hacker-news-square:before {
+  content: "\f3af"; }
+
+.fa-edge:before {
+  content: "\f282"; }
+
+.fa-threads:before {
+  content: "\e618"; }
+
+.fa-napster:before {
+  content: "\f3d2"; }
+
+.fa-square-snapchat:before {
+  content: "\f2ad"; }
+
+.fa-snapchat-square:before {
+  content: "\f2ad"; }
+
+.fa-google-plus-g:before {
+  content: "\f0d5"; }
+
+.fa-artstation:before {
+  content: "\f77a"; }
+
+.fa-markdown:before {
+  content: "\f60f"; }
+
+.fa-sourcetree:before {
+  content: "\f7d3"; }
+
+.fa-google-plus:before {
+  content: "\f2b3"; }
+
+.fa-diaspora:before {
+  content: "\f791"; }
+
+.fa-foursquare:before {
+  content: "\f180"; }
+
+.fa-stack-overflow:before {
+  content: "\f16c"; }
+
+.fa-github-alt:before {
+  content: "\f113"; }
+
+.fa-phoenix-squadron:before {
+  content: "\f511"; }
+
+.fa-pagelines:before {
+  content: "\f18c"; }
+
+.fa-algolia:before {
+  content: "\f36c"; }
+
+.fa-red-river:before {
+  content: "\f3e3"; }
+
+.fa-creative-commons-sa:before {
+  content: "\f4ef"; }
+
+.fa-safari:before {
+  content: "\f267"; }
+
+.fa-google:before {
+  content: "\f1a0"; }
+
+.fa-square-font-awesome-stroke:before {
+  content: "\f35c"; }
+
+.fa-font-awesome-alt:before {
+  content: "\f35c"; }
+
+.fa-atlassian:before {
+  content: "\f77b"; }
+
+.fa-linkedin-in:before {
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+  content: "\f286"; }
+
+.fa-waze:before {
+  content: "\f83f"; }
+
+.fa-cc-jcb:before {
+  content: "\f24b"; }
+
+.fa-snapchat:before {
+  content: "\f2ab"; }
+
+.fa-snapchat-ghost:before {
+  content: "\f2ab"; }
+
+.fa-fantasy-flight-games:before {
+  content: "\f6dc"; }
+
+.fa-rust:before {
+  content: "\e07a"; }
+
+.fa-wix:before {
+  content: "\f5cf"; }
+
+.fa-square-behance:before {
+  content: "\f1b5"; }
+
+.fa-behance-square:before {
+  content: "\f1b5"; }
+
+.fa-supple:before {
+  content: "\f3f9"; }
+
+.fa-rebel:before {
+  content: "\f1d0"; }
+
+.fa-css3:before {
+  content: "\f13c"; }
+
+.fa-staylinked:before {
+  content: "\f3f5"; }
+
+.fa-kaggle:before {
+  content: "\f5fa"; }
+
+.fa-space-awesome:before {
+  content: "\e5ac"; }
+
+.fa-deviantart:before {
+  content: "\f1bd"; }
+
+.fa-cpanel:before {
+  content: "\f388"; }
+
+.fa-goodreads-g:before {
+  content: "\f3a9"; }
+
+.fa-square-git:before {
+  content: "\f1d2"; }
+
+.fa-git-square:before {
+  content: "\f1d2"; }
+
+.fa-square-tumblr:before {
+  content: "\f174"; }
+
+.fa-tumblr-square:before {
+  content: "\f174"; }
+
+.fa-trello:before {
+  content: "\f181"; }
+
+.fa-creative-commons-nc-jp:before {
+  content: "\f4ea"; }
+
+.fa-get-pocket:before {
+  content: "\f265"; }
+
+.fa-perbyte:before {
+  content: "\e083"; }
+
+.fa-grunt:before {
+  content: "\f3ad"; }
+
+.fa-weebly:before {
+  content: "\f5cc"; }
+
+.fa-connectdevelop:before {
+  content: "\f20e"; }
+
+.fa-leanpub:before {
+  content: "\f212"; }
+
+.fa-black-tie:before {
+  content: "\f27e"; }
+
+.fa-themeco:before {
+  content: "\f5c6"; }
+
+.fa-python:before {
+  content: "\f3e2"; }
+
+.fa-android:before {
+  content: "\f17b"; }
+
+.fa-bots:before {
+  content: "\e340"; }
+
+.fa-free-code-camp:before {
+  content: "\f2c5"; }
+
+.fa-hornbill:before {
+  content: "\f592"; }
+
+.fa-js:before {
+  content: "\f3b8"; }
+
+.fa-ideal:before {
+  content: "\e013"; }
+
+.fa-git:before {
+  content: "\f1d3"; }
+
+.fa-dev:before {
+  content: "\f6cc"; }
+
+.fa-sketch:before {
+  content: "\f7c6"; }
+
+.fa-yandex-international:before {
+  content: "\f414"; }
+
+.fa-cc-amex:before {
+  content: "\f1f3"; }
+
+.fa-uber:before {
+  content: "\f402"; }
+
+.fa-github:before {
+  content: "\f09b"; }
+
+.fa-php:before {
+  content: "\f457"; }
+
+.fa-alipay:before {
+  content: "\f642"; }
+
+.fa-youtube:before {
+  content: "\f167"; }
+
+.fa-skyatlas:before {
+  content: "\f216"; }
+
+.fa-firefox-browser:before {
+  content: "\e007"; }
+
+.fa-replyd:before {
+  content: "\f3e6"; }
+
+.fa-suse:before {
+  content: "\f7d6"; }
+
+.fa-jenkins:before {
+  content: "\f3b6"; }
+
+.fa-twitter:before {
+  content: "\f099"; }
+
+.fa-rockrms:before {
+  content: "\f3e9"; }
+
+.fa-pinterest:before {
+  content: "\f0d2"; }
+
+.fa-buffer:before {
+  content: "\f837"; }
+
+.fa-npm:before {
+  content: "\f3d4"; }
+
+.fa-yammer:before {
+  content: "\f840"; }
+
+.fa-btc:before {
+  content: "\f15a"; }
+
+.fa-dribbble:before {
+  content: "\f17d"; }
+
+.fa-stumbleupon-circle:before {
+  content: "\f1a3"; }
+
+.fa-internet-explorer:before {
+  content: "\f26b"; }
+
+.fa-stubber:before {
+  content: "\e5c7"; }
+
+.fa-telegram:before {
+  content: "\f2c6"; }
+
+.fa-telegram-plane:before {
+  content: "\f2c6"; }
+
+.fa-old-republic:before {
+  content: "\f510"; }
+
+.fa-odysee:before {
+  content: "\e5c6"; }
+
+.fa-square-whatsapp:before {
+  content: "\f40c"; }
+
+.fa-whatsapp-square:before {
+  content: "\f40c"; }
+
+.fa-node-js:before {
+  content: "\f3d3"; }
+
+.fa-edge-legacy:before {
+  content: "\e078"; }
+
+.fa-slack:before {
+  content: "\f198"; }
+
+.fa-slack-hash:before {
+  content: "\f198"; }
+
+.fa-medrt:before {
+  content: "\f3c8"; }
+
+.fa-usb:before {
+  content: "\f287"; }
+
+.fa-tumblr:before {
+  content: "\f173"; }
+
+.fa-vaadin:before {
+  content: "\f408"; }
+
+.fa-quora:before {
+  content: "\f2c4"; }
+
+.fa-square-x-twitter:before {
+  content: "\e61a"; }
+
+.fa-reacteurope:before {
+  content: "\f75d"; }
+
+.fa-medium:before {
+  content: "\f23a"; }
+
+.fa-medium-m:before {
+  content: "\f23a"; }
+
+.fa-amilia:before {
+  content: "\f36d"; }
+
+.fa-mixcloud:before {
+  content: "\f289"; }
+
+.fa-flipboard:before {
+  content: "\f44d"; }
+
+.fa-viacoin:before {
+  content: "\f237"; }
+
+.fa-critical-role:before {
+  content: "\f6c9"; }
+
+.fa-sitrox:before {
+  content: "\e44a"; }
+
+.fa-discourse:before {
+  content: "\f393"; }
+
+.fa-joomla:before {
+  content: "\f1aa"; }
+
+.fa-mastodon:before {
+  content: "\f4f6"; }
+
+.fa-airbnb:before {
+  content: "\f834"; }
+
+.fa-wolf-pack-battalion:before {
+  content: "\f514"; }
+
+.fa-buy-n-large:before {
+  content: "\f8a6"; }
+
+.fa-gulp:before {
+  content: "\f3ae"; }
+
+.fa-creative-commons-sampling-plus:before {
+  content: "\f4f1"; }
+
+.fa-strava:before {
+  content: "\f428"; }
+
+.fa-ember:before {
+  content: "\f423"; }
+
+.fa-canadian-maple-leaf:before {
+  content: "\f785"; }
+
+.fa-teamspeak:before {
+  content: "\f4f9"; }
+
+.fa-pushed:before {
+  content: "\f3e1"; }
+
+.fa-wordpress-simple:before {
+  content: "\f411"; }
+
+.fa-nutritionix:before {
+  content: "\f3d6"; }
+
+.fa-wodu:before {
+  content: "\e088"; }
+
+.fa-google-pay:before {
+  content: "\e079"; }
+
+.fa-intercom:before {
+  content: "\f7af"; }
+
+.fa-zhihu:before {
+  content: "\f63f"; }
+
+.fa-korvue:before {
+  content: "\f42f"; }
+
+.fa-pix:before {
+  content: "\e43a"; }
+
+.fa-steam-symbol:before {
+  content: "\f3f6"; }
+:root, :host {
+  --fa-style-family-classic: 'Font Awesome 6 Free';
+  --fa-font-regular: normal 400 1em/1 'Font Awesome 6 Free'; }
+
+@font-face {
+  font-family: 'Font Awesome 6 Free';
+  font-style: normal;
+  font-weight: 400;
+  font-display: block;
+  src: url("../webfonts/fa-regular-400.woff2") format("woff2"), url("../webfonts/fa-regular-400.ttf") format("truetype"); }
+
+.far,
+.fa-regular {
+  font-weight: 400; }
+:root, :host {
+  --fa-style-family-classic: 'Font Awesome 6 Free';
+  --fa-font-solid: normal 900 1em/1 'Font Awesome 6 Free'; }
+
+@font-face {
+  font-family: 'Font Awesome 6 Free';
+  font-style: normal;
+  font-weight: 900;
+  font-display: block;
+  src: url("../webfonts/fa-solid-900.woff2") format("woff2"), url("../webfonts/fa-solid-900.ttf") format("truetype"); }
+
+.fas,
+.fa-solid {
+  font-weight: 900; }
+@font-face {
+  font-family: 'Font Awesome 5 Brands';
+  font-display: block;
+  font-weight: 400;
+  src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'Font Awesome 5 Free';
+  font-display: block;
+  font-weight: 900;
+  src: url("../webfonts/fa-solid-900.woff2") format("woff2"), url("../webfonts/fa-solid-900.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'Font Awesome 5 Free';
+  font-display: block;
+  font-weight: 400;
+  src: url("../webfonts/fa-regular-400.woff2") format("woff2"), url("../webfonts/fa-regular-400.ttf") format("truetype"); }
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-solid-900.woff2") format("woff2"), url("../webfonts/fa-solid-900.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-regular-400.woff2") format("woff2"), url("../webfonts/fa-regular-400.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-v4compatibility.woff2") format("woff2"), url("../webfonts/fa-v4compatibility.ttf") format("truetype"); }
diff --git a/docs/deps/font-awesome-6.4.2/css/all.min.css b/docs/deps/font-awesome-6.4.2/css/all.min.css
new file mode 100644
index 0000000..6604a06
--- /dev/null
+++ b/docs/deps/font-awesome-6.4.2/css/all.min.css
@@ -0,0 +1,9 @@
+/*!
+ * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2023 Fonticons, Inc.
+ */
+.fa{font-family:var(--fa-style-family,"Font Awesome 6 Free");font-weight:var(--fa-style,900)}.fa,.fa-brands,.fa-classic,.fa-regular,.fa-sharp,.fa-solid,.fab,.far,.fas{-moz-osx-font-smoothing:grayscale;-webkit-font-smoothing:antialiased;display:var(--fa-display,inline-block);font-style:normal;font-variant:normal;line-height:1;text-rendering:auto}.fa-classic,.fa-regular,.fa-solid,.far,.fas{font-family:"Font Awesome 6 Free"}.fa-brands,.fab{font-family:"Font Awesome 6 Brands"}.fa-1x{font-size:1em}.fa-2x{font-size:2em}.fa-3x{font-size:3em}.fa-4x{font-size:4em}.fa-5x{font-size:5em}.fa-6x{font-size:6em}.fa-7x{font-size:7em}.fa-8x{font-size:8em}.fa-9x{font-size:9em}.fa-10x{font-size:10em}.fa-2xs{font-size:.625em;line-height:.1em;vertical-align:.225em}.fa-xs{font-size:.75em;line-height:.08333em;vertical-align:.125em}.fa-sm{font-size:.875em;line-height:.07143em;vertical-align:.05357em}.fa-lg{font-size:1.25em;line-height:.05em;vertical-align:-.075em}.fa-xl{font-size:1.5em;line-height:.04167em;vertical-align:-.125em}.fa-2xl{font-size:2em;line-height:.03125em;vertical-align:-.1875em}.fa-fw{text-align:center;width:1.25em}.fa-ul{list-style-type:none;margin-left:var(--fa-li-margin,2.5em);padding-left:0}.fa-ul>li{position:relative}.fa-li{left:calc(var(--fa-li-width, 2em)*-1);position:absolute;text-align:center;width:var(--fa-li-width,2em);line-height:inherit}.fa-border{border-radius:var(--fa-border-radius,.1em);border:var(--fa-border-width,.08em) var(--fa-border-style,solid) var(--fa-border-color,#eee);padding:var(--fa-border-padding,.2em .25em .15em)}.fa-pull-left{float:left;margin-right:var(--fa-pull-margin,.3em)}.fa-pull-right{float:right;margin-left:var(--fa-pull-margin,.3em)}.fa-beat{-webkit-animation-name:fa-beat;animation-name:fa-beat;-webkit-animation-delay:var(--fa-animation-delay,0s);animation-delay:var(--fa-animation-delay,0s);-webkit-animation-direction:var(--fa-animation-direction,normal);animation-direction:var(--fa-animation-direction,normal);-webkit-animation-duration:var(--fa-animation-duration,1s);animation-duration:var(--fa-animation-duration,1s);-webkit-animation-iteration-count:var(--fa-animation-iteration-count,infinite);animation-iteration-count:var(--fa-animation-iteration-count,infinite);-webkit-animation-timing-function:var(--fa-animation-timing,ease-in-out);animation-timing-function:var(--fa-animation-timing,ease-in-out)}.fa-bounce{-webkit-animation-name:fa-bounce;animation-name:fa-bounce;-webkit-animation-delay:var(--fa-animation-delay,0s);animation-delay:var(--fa-animation-delay,0s);-webkit-animation-direction:var(--fa-animation-direction,normal);animation-direction:var(--fa-animation-direction,normal);-webkit-animation-duration:var(--fa-animation-duration,1s);animation-duration:var(--fa-animation-duration,1s);-webkit-animation-iteration-count:var(--fa-animation-iteration-count,infinite);animation-iteration-count:var(--fa-animation-iteration-count,infinite);-webkit-animation-timing-function:var(--fa-animation-timing,cubic-bezier(.28,.84,.42,1));animation-timing-function:var(--fa-animation-timing,cubic-bezier(.28,.84,.42,1))}.fa-fade{-webkit-animation-name:fa-fade;animation-name:fa-fade;-webkit-animation-iteration-count:var(--fa-animation-iteration-count,infinite);animation-iteration-count:var(--fa-animation-iteration-count,infinite);-webkit-animation-timing-function:var(--fa-animation-timing,cubic-bezier(.4,0,.6,1));animation-timing-function:var(--fa-animation-timing,cubic-bezier(.4,0,.6,1))}.fa-beat-fade,.fa-fade{-webkit-animation-delay:var(--fa-animation-delay,0s);animation-delay:var(--fa-animation-delay,0s);-webkit-animation-direction:var(--fa-animation-direction,normal);animation-direction:var(--fa-animation-direction,normal);-webkit-animation-duration:var(--fa-animation-duration,1s);animation-duration:var(--fa-animation-duration,1s)}.fa-beat-fade{-webkit-animation-name:fa-beat-fade;animation-name:fa-beat-fade;-webkit-animation-iteration-count:var(--fa-animation-iteration-count,infinite);animation-iteration-count:var(--fa-animation-iteration-count,infinite);-webkit-animation-timing-function:var(--fa-animation-timing,cubic-bezier(.4,0,.6,1));animation-timing-function:var(--fa-animation-timing,cubic-bezier(.4,0,.6,1))}.fa-flip{-webkit-animation-name:fa-flip;animation-name:fa-flip;-webkit-animation-delay:var(--fa-animation-delay,0s);animation-delay:var(--fa-animation-delay,0s);-webkit-animation-direction:var(--fa-animation-direction,normal);animation-direction:var(--fa-animation-direction,normal);-webkit-animation-duration:var(--fa-animation-duration,1s);animation-duration:var(--fa-animation-duration,1s);-webkit-animation-iteration-count:var(--fa-animation-iteration-count,infinite);animation-iteration-count:var(--fa-animation-iteration-count,infinite);-webkit-animation-timing-function:var(--fa-animation-timing,ease-in-out);animation-timing-function:var(--fa-animation-timing,ease-in-out)}.fa-shake{-webkit-animation-name:fa-shake;animation-name:fa-shake;-webkit-animation-duration:var(--fa-animation-duration,1s);animation-duration:var(--fa-animation-duration,1s);-webkit-animation-iteration-count:var(--fa-animation-iteration-count,infinite);animation-iteration-count:var(--fa-animation-iteration-count,infinite);-webkit-animation-timing-function:var(--fa-animation-timing,linear);animation-timing-function:var(--fa-animation-timing,linear)}.fa-shake,.fa-spin{-webkit-animation-delay:var(--fa-animation-delay,0s);animation-delay:var(--fa-animation-delay,0s);-webkit-animation-direction:var(--fa-animation-direction,normal);animation-direction:var(--fa-animation-direction,normal)}.fa-spin{-webkit-animation-name:fa-spin;animation-name:fa-spin;-webkit-animation-duration:var(--fa-animation-duration,2s);animation-duration:var(--fa-animation-duration,2s);-webkit-animation-iteration-count:var(--fa-animation-iteration-count,infinite);animation-iteration-count:var(--fa-animation-iteration-count,infinite);-webkit-animation-timing-function:var(--fa-animation-timing,linear);animation-timing-function:var(--fa-animation-timing,linear)}.fa-spin-reverse{--fa-animation-direction:reverse}.fa-pulse,.fa-spin-pulse{-webkit-animation-name:fa-spin;animation-name:fa-spin;-webkit-animation-direction:var(--fa-animation-direction,normal);animation-direction:var(--fa-animation-direction,normal);-webkit-animation-duration:var(--fa-animation-duration,1s);animation-duration:var(--fa-animation-duration,1s);-webkit-animation-iteration-count:var(--fa-animation-iteration-count,infinite);animation-iteration-count:var(--fa-animation-iteration-count,infinite);-webkit-animation-timing-function:var(--fa-animation-timing,steps(8));animation-timing-function:var(--fa-animation-timing,steps(8))}@media (prefers-reduced-motion:reduce){.fa-beat,.fa-beat-fade,.fa-bounce,.fa-fade,.fa-flip,.fa-pulse,.fa-shake,.fa-spin,.fa-spin-pulse{-webkit-animation-delay:-1ms;animation-delay:-1ms;-webkit-animation-duration:1ms;animation-duration:1ms;-webkit-animation-iteration-count:1;animation-iteration-count:1;-webkit-transition-delay:0s;transition-delay:0s;-webkit-transition-duration:0s;transition-duration:0s}}@-webkit-keyframes fa-beat{0%,90%{-webkit-transform:scale(1);transform:scale(1)}45%{-webkit-transform:scale(var(--fa-beat-scale,1.25));transform:scale(var(--fa-beat-scale,1.25))}}@keyframes fa-beat{0%,90%{-webkit-transform:scale(1);transform:scale(1)}45%{-webkit-transform:scale(var(--fa-beat-scale,1.25));transform:scale(var(--fa-beat-scale,1.25))}}@-webkit-keyframes fa-bounce{0%{-webkit-transform:scale(1) translateY(0);transform:scale(1) translateY(0)}10%{-webkit-transform:scale(var(--fa-bounce-start-scale-x,1.1),var(--fa-bounce-start-scale-y,.9)) 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\ No newline at end of file
diff --git a/docs/deps/font-awesome-6.4.2/css/v4-shims.css b/docs/deps/font-awesome-6.4.2/css/v4-shims.css
new file mode 100644
index 0000000..a85953d
--- /dev/null
+++ b/docs/deps/font-awesome-6.4.2/css/v4-shims.css
@@ -0,0 +1,2194 @@
+/*!
+ * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2023 Fonticons, Inc.
+ */
+.fa.fa-glass:before {
+  content: "\f000"; }
+
+.fa.fa-envelope-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-envelope-o:before {
+  content: "\f0e0"; }
+
+.fa.fa-star-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-star-o:before {
+  content: "\f005"; }
+
+.fa.fa-remove:before {
+  content: "\f00d"; }
+
+.fa.fa-close:before {
+  content: "\f00d"; }
+
+.fa.fa-gear:before {
+  content: "\f013"; }
+
+.fa.fa-trash-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-trash-o:before {
+  content: "\f2ed"; }
+
+.fa.fa-home:before {
+  content: "\f015"; }
+
+.fa.fa-file-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-file-o:before {
+  content: "\f15b"; }
+
+.fa.fa-clock-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-clock-o:before {
+  content: "\f017"; }
+
+.fa.fa-arrow-circle-o-down {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-arrow-circle-o-down:before {
+  content: "\f358"; }
+
+.fa.fa-arrow-circle-o-up {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-arrow-circle-o-up:before {
+  content: "\f35b"; }
+
+.fa.fa-play-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-play-circle-o:before {
+  content: "\f144"; }
+
+.fa.fa-repeat:before {
+  content: "\f01e"; }
+
+.fa.fa-rotate-right:before {
+  content: "\f01e"; }
+
+.fa.fa-refresh:before {
+  content: "\f021"; }
+
+.fa.fa-list-alt {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-list-alt:before {
+  content: "\f022"; }
+
+.fa.fa-dedent:before {
+  content: "\f03b"; }
+
+.fa.fa-video-camera:before {
+  content: "\f03d"; }
+
+.fa.fa-picture-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-picture-o:before {
+  content: "\f03e"; }
+
+.fa.fa-photo {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-photo:before {
+  content: "\f03e"; }
+
+.fa.fa-image {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-image:before {
+  content: "\f03e"; }
+
+.fa.fa-map-marker:before {
+  content: "\f3c5"; }
+
+.fa.fa-pencil-square-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-pencil-square-o:before {
+  content: "\f044"; }
+
+.fa.fa-edit {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-edit:before {
+  content: "\f044"; }
+
+.fa.fa-share-square-o:before {
+  content: "\f14d"; }
+
+.fa.fa-check-square-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-check-square-o:before {
+  content: "\f14a"; }
+
+.fa.fa-arrows:before {
+  content: "\f0b2"; }
+
+.fa.fa-times-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-times-circle-o:before {
+  content: "\f057"; }
+
+.fa.fa-check-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-check-circle-o:before {
+  content: "\f058"; }
+
+.fa.fa-mail-forward:before {
+  content: "\f064"; }
+
+.fa.fa-expand:before {
+  content: "\f424"; }
+
+.fa.fa-compress:before {
+  content: "\f422"; }
+
+.fa.fa-eye {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-eye-slash {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-warning:before {
+  content: "\f071"; }
+
+.fa.fa-calendar:before {
+  content: "\f073"; }
+
+.fa.fa-arrows-v:before {
+  content: "\f338"; }
+
+.fa.fa-arrows-h:before {
+  content: "\f337"; }
+
+.fa.fa-bar-chart:before {
+  content: "\e0e3"; }
+
+.fa.fa-bar-chart-o:before {
+  content: "\e0e3"; }
+
+.fa.fa-twitter-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-twitter-square:before {
+  content: "\f081"; }
+
+.fa.fa-facebook-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-facebook-square:before {
+  content: "\f082"; }
+
+.fa.fa-gears:before {
+  content: "\f085"; }
+
+.fa.fa-thumbs-o-up {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-thumbs-o-up:before {
+  content: "\f164"; }
+
+.fa.fa-thumbs-o-down {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-thumbs-o-down:before {
+  content: "\f165"; }
+
+.fa.fa-heart-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-heart-o:before {
+  content: "\f004"; }
+
+.fa.fa-sign-out:before {
+  content: "\f2f5"; }
+
+.fa.fa-linkedin-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-linkedin-square:before {
+  content: "\f08c"; }
+
+.fa.fa-thumb-tack:before {
+  content: "\f08d"; }
+
+.fa.fa-external-link:before {
+  content: "\f35d"; }
+
+.fa.fa-sign-in:before {
+  content: "\f2f6"; }
+
+.fa.fa-github-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-github-square:before {
+  content: "\f092"; }
+
+.fa.fa-lemon-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-lemon-o:before {
+  content: "\f094"; }
+
+.fa.fa-square-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-square-o:before {
+  content: "\f0c8"; }
+
+.fa.fa-bookmark-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-bookmark-o:before {
+  content: "\f02e"; }
+
+.fa.fa-twitter {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-facebook {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-facebook:before {
+  content: "\f39e"; }
+
+.fa.fa-facebook-f {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-facebook-f:before {
+  content: "\f39e"; }
+
+.fa.fa-github {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-credit-card {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-feed:before {
+  content: "\f09e"; }
+
+.fa.fa-hdd-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hdd-o:before {
+  content: "\f0a0"; }
+
+.fa.fa-hand-o-right {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-o-right:before {
+  content: "\f0a4"; }
+
+.fa.fa-hand-o-left {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-o-left:before {
+  content: "\f0a5"; }
+
+.fa.fa-hand-o-up {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-o-up:before {
+  content: "\f0a6"; }
+
+.fa.fa-hand-o-down {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-o-down:before {
+  content: "\f0a7"; }
+
+.fa.fa-globe:before {
+  content: "\f57d"; }
+
+.fa.fa-tasks:before {
+  content: "\f828"; }
+
+.fa.fa-arrows-alt:before {
+  content: "\f31e"; }
+
+.fa.fa-group:before {
+  content: "\f0c0"; }
+
+.fa.fa-chain:before {
+  content: "\f0c1"; }
+
+.fa.fa-cut:before {
+  content: "\f0c4"; }
+
+.fa.fa-files-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-files-o:before {
+  content: "\f0c5"; }
+
+.fa.fa-floppy-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-floppy-o:before {
+  content: "\f0c7"; }
+
+.fa.fa-save {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-save:before {
+  content: "\f0c7"; }
+
+.fa.fa-navicon:before {
+  content: "\f0c9"; }
+
+.fa.fa-reorder:before {
+  content: "\f0c9"; }
+
+.fa.fa-magic:before {
+  content: "\e2ca"; }
+
+.fa.fa-pinterest {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-pinterest-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-pinterest-square:before {
+  content: "\f0d3"; }
+
+.fa.fa-google-plus-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-square:before {
+  content: "\f0d4"; }
+
+.fa.fa-google-plus {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus:before {
+  content: "\f0d5"; }
+
+.fa.fa-money:before {
+  content: "\f3d1"; }
+
+.fa.fa-unsorted:before {
+  content: "\f0dc"; }
+
+.fa.fa-sort-desc:before {
+  content: "\f0dd"; }
+
+.fa.fa-sort-asc:before {
+  content: "\f0de"; }
+
+.fa.fa-linkedin {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-linkedin:before {
+  content: "\f0e1"; }
+
+.fa.fa-rotate-left:before {
+  content: "\f0e2"; }
+
+.fa.fa-legal:before {
+  content: "\f0e3"; }
+
+.fa.fa-tachometer:before {
+  content: "\f625"; }
+
+.fa.fa-dashboard:before {
+  content: "\f625"; }
+
+.fa.fa-comment-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-comment-o:before {
+  content: "\f075"; }
+
+.fa.fa-comments-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-comments-o:before {
+  content: "\f086"; }
+
+.fa.fa-flash:before {
+  content: "\f0e7"; }
+
+.fa.fa-clipboard:before {
+  content: "\f0ea"; }
+
+.fa.fa-lightbulb-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-lightbulb-o:before {
+  content: "\f0eb"; }
+
+.fa.fa-exchange:before {
+  content: "\f362"; }
+
+.fa.fa-cloud-download:before {
+  content: "\f0ed"; }
+
+.fa.fa-cloud-upload:before {
+  content: "\f0ee"; }
+
+.fa.fa-bell-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-bell-o:before {
+  content: "\f0f3"; }
+
+.fa.fa-cutlery:before {
+  content: "\f2e7"; }
+
+.fa.fa-file-text-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-file-text-o:before {
+  content: "\f15c"; }
+
+.fa.fa-building-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-building-o:before {
+  content: "\f1ad"; }
+
+.fa.fa-hospital-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hospital-o:before {
+  content: "\f0f8"; }
+
+.fa.fa-tablet:before {
+  content: "\f3fa"; }
+
+.fa.fa-mobile:before {
+  content: "\f3cd"; }
+
+.fa.fa-mobile-phone:before {
+  content: "\f3cd"; }
+
+.fa.fa-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-circle-o:before {
+  content: "\f111"; }
+
+.fa.fa-mail-reply:before {
+  content: "\f3e5"; }
+
+.fa.fa-github-alt {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-folder-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-folder-o:before {
+  content: "\f07b"; }
+
+.fa.fa-folder-open-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-folder-open-o:before {
+  content: "\f07c"; }
+
+.fa.fa-smile-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-smile-o:before {
+  content: "\f118"; }
+
+.fa.fa-frown-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-frown-o:before {
+  content: "\f119"; }
+
+.fa.fa-meh-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-meh-o:before {
+  content: "\f11a"; }
+
+.fa.fa-keyboard-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-keyboard-o:before {
+  content: "\f11c"; }
+
+.fa.fa-flag-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-flag-o:before {
+  content: "\f024"; }
+
+.fa.fa-mail-reply-all:before {
+  content: "\f122"; }
+
+.fa.fa-star-half-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-star-half-o:before {
+  content: "\f5c0"; }
+
+.fa.fa-star-half-empty {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-star-half-empty:before {
+  content: "\f5c0"; }
+
+.fa.fa-star-half-full {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-star-half-full:before {
+  content: "\f5c0"; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-cc {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-cc:before {
+  content: "\f20a"; }
+
+.fa.fa-ils:before {
+  content: "\f20b"; }
+
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+  content: "\f20b"; }
+
+.fa.fa-sheqel:before {
+  content: "\f20b"; }
+
+.fa.fa-buysellads {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-dashcube {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-forumbee {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-sellsy {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-shirtsinbulk {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-skyatlas {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-diamond {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-diamond:before {
+  content: "\f3a5"; }
+
+.fa.fa-transgender:before {
+  content: "\f224"; }
+
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+  content: "\f224"; }
+
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+  content: "\f225"; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  content: "\f09a"; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-whatsapp {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  content: "\f236"; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
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+  content: "\f23b"; }
+
+.fa.fa-optin-monster {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-opencart {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-expeditedssl {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-battery-4:before {
+  content: "\f240"; }
+
+.fa.fa-battery:before {
+  content: "\f240"; }
+
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+  content: "\f241"; }
+
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+  content: "\f242"; }
+
+.fa.fa-battery-1:before {
+  content: "\f243"; }
+
+.fa.fa-battery-0:before {
+  content: "\f244"; }
+
+.fa.fa-object-group {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
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+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
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+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
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+  content: "\f249"; }
+
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-cc-diners-club {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-clone {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
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+  content: "\f254"; }
+
+.fa.fa-hourglass-1:before {
+  content: "\f251"; }
+
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+  content: "\f252"; }
+
+.fa.fa-hourglass-3:before {
+  content: "\f253"; }
+
+.fa.fa-hand-rock-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-rock-o:before {
+  content: "\f255"; }
+
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+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-grab-o:before {
+  content: "\f255"; }
+
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+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
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+  content: "\f256"; }
+
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+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
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+  content: "\f256"; }
+
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+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-scissors-o:before {
+  content: "\f257"; }
+
+.fa.fa-hand-lizard-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-lizard-o:before {
+  content: "\f258"; }
+
+.fa.fa-hand-spock-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-spock-o:before {
+  content: "\f259"; }
+
+.fa.fa-hand-pointer-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-pointer-o:before {
+  content: "\f25a"; }
+
+.fa.fa-hand-peace-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-hand-peace-o:before {
+  content: "\f25b"; }
+
+.fa.fa-registered {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-creative-commons {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-gg {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-gg-circle {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-odnoklassniki {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-odnoklassniki-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-odnoklassniki-square:before {
+  content: "\f264"; }
+
+.fa.fa-get-pocket {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wikipedia-w {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-safari {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-chrome {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-firefox {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-opera {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-internet-explorer {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-television:before {
+  content: "\f26c"; }
+
+.fa.fa-contao {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-500px {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-amazon {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-calendar-plus-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-calendar-plus-o:before {
+  content: "\f271"; }
+
+.fa.fa-calendar-minus-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-calendar-minus-o:before {
+  content: "\f272"; }
+
+.fa.fa-calendar-times-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-calendar-times-o:before {
+  content: "\f273"; }
+
+.fa.fa-calendar-check-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-calendar-check-o:before {
+  content: "\f274"; }
+
+.fa.fa-map-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-map-o:before {
+  content: "\f279"; }
+
+.fa.fa-commenting:before {
+  content: "\f4ad"; }
+
+.fa.fa-commenting-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-commenting-o:before {
+  content: "\f4ad"; }
+
+.fa.fa-houzz {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-vimeo {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-vimeo:before {
+  content: "\f27d"; }
+
+.fa.fa-black-tie {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-fonticons {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-reddit-alien {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-edge {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-credit-card-alt:before {
+  content: "\f09d"; }
+
+.fa.fa-codiepie {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-modx {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-fort-awesome {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-usb {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-product-hunt {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-mixcloud {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-scribd {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-pause-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-pause-circle-o:before {
+  content: "\f28b"; }
+
+.fa.fa-stop-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-stop-circle-o:before {
+  content: "\f28d"; }
+
+.fa.fa-bluetooth {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-bluetooth-b {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-gitlab {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wpbeginner {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wpforms {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-envira {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wheelchair-alt {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wheelchair-alt:before {
+  content: "\f368"; }
+
+.fa.fa-question-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-question-circle-o:before {
+  content: "\f059"; }
+
+.fa.fa-volume-control-phone:before {
+  content: "\f2a0"; }
+
+.fa.fa-asl-interpreting:before {
+  content: "\f2a3"; }
+
+.fa.fa-deafness:before {
+  content: "\f2a4"; }
+
+.fa.fa-hard-of-hearing:before {
+  content: "\f2a4"; }
+
+.fa.fa-glide {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-glide-g {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-signing:before {
+  content: "\f2a7"; }
+
+.fa.fa-viadeo {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-viadeo-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-viadeo-square:before {
+  content: "\f2aa"; }
+
+.fa.fa-snapchat {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-snapchat-ghost {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-snapchat-ghost:before {
+  content: "\f2ab"; }
+
+.fa.fa-snapchat-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-snapchat-square:before {
+  content: "\f2ad"; }
+
+.fa.fa-pied-piper {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-first-order {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-yoast {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-themeisle {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-official {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-official:before {
+  content: "\f2b3"; }
+
+.fa.fa-google-plus-circle {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-circle:before {
+  content: "\f2b3"; }
+
+.fa.fa-font-awesome {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-fa {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-fa:before {
+  content: "\f2b4"; }
+
+.fa.fa-handshake-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-handshake-o:before {
+  content: "\f2b5"; }
+
+.fa.fa-envelope-open-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-envelope-open-o:before {
+  content: "\f2b6"; }
+
+.fa.fa-linode {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-address-book-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-address-book-o:before {
+  content: "\f2b9"; }
+
+.fa.fa-vcard:before {
+  content: "\f2bb"; }
+
+.fa.fa-address-card-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-address-card-o:before {
+  content: "\f2bb"; }
+
+.fa.fa-vcard-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-vcard-o:before {
+  content: "\f2bb"; }
+
+.fa.fa-user-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-user-circle-o:before {
+  content: "\f2bd"; }
+
+.fa.fa-user-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-user-o:before {
+  content: "\f007"; }
+
+.fa.fa-id-badge {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-drivers-license:before {
+  content: "\f2c2"; }
+
+.fa.fa-id-card-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-id-card-o:before {
+  content: "\f2c2"; }
+
+.fa.fa-drivers-license-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-drivers-license-o:before {
+  content: "\f2c2"; }
+
+.fa.fa-quora {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-free-code-camp {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-telegram {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-thermometer-4:before {
+  content: "\f2c7"; }
+
+.fa.fa-thermometer:before {
+  content: "\f2c7"; }
+
+.fa.fa-thermometer-3:before {
+  content: "\f2c8"; }
+
+.fa.fa-thermometer-2:before {
+  content: "\f2c9"; }
+
+.fa.fa-thermometer-1:before {
+  content: "\f2ca"; }
+
+.fa.fa-thermometer-0:before {
+  content: "\f2cb"; }
+
+.fa.fa-bathtub:before {
+  content: "\f2cd"; }
+
+.fa.fa-s15:before {
+  content: "\f2cd"; }
+
+.fa.fa-window-maximize {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-window-restore {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-times-rectangle:before {
+  content: "\f410"; }
+
+.fa.fa-window-close-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-window-close-o:before {
+  content: "\f410"; }
+
+.fa.fa-times-rectangle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-times-rectangle-o:before {
+  content: "\f410"; }
+
+.fa.fa-bandcamp {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-grav {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-etsy {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-imdb {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-ravelry {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-eercast {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-eercast:before {
+  content: "\f2da"; }
+
+.fa.fa-snowflake-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-snowflake-o:before {
+  content: "\f2dc"; }
+
+.fa.fa-superpowers {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wpexplorer {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-meetup {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
diff --git a/docs/deps/font-awesome-6.4.2/css/v4-shims.min.css b/docs/deps/font-awesome-6.4.2/css/v4-shims.min.css
new file mode 100644
index 0000000..64e4e8d
--- /dev/null
+++ b/docs/deps/font-awesome-6.4.2/css/v4-shims.min.css
@@ -0,0 +1,6 @@
+/*!
+ * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2023 Fonticons, Inc.
+ */
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new file mode 100644
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+++ b/docs/deps/headroom-0.11.0/headroom.min.js
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+/*!
+ * headroom.js v0.11.0 - Give your page some headroom. Hide your header until you need it
+ * Copyright (c) 2020 Nick Williams - http://wicky.nillia.ms/headroom.js
+ * License: MIT
+ */
+
+!function(t,n){"object"==typeof exports&&"undefined"!=typeof module?module.exports=n():"function"==typeof define&&define.amd?define(n):(t=t||self).Headroom=n()}(this,function(){"use strict";function t(){return"undefined"!=typeof window}function d(t){return function(t){return t&&t.document&&function(t){return 9===t.nodeType}(t.document)}(t)?function(t){var n=t.document,o=n.body,s=n.documentElement;return{scrollHeight:function(){return Math.max(o.scrollHeight,s.scrollHeight,o.offsetHeight,s.offsetHeight,o.clientHeight,s.clientHeight)},height:function(){return t.innerHeight||s.clientHeight||o.clientHeight},scrollY:function(){return void 0!==t.pageYOffset?t.pageYOffset:(s||o.parentNode||o).scrollTop}}}(t):function(t){return{scrollHeight:function(){return Math.max(t.scrollHeight,t.offsetHeight,t.clientHeight)},height:function(){return Math.max(t.offsetHeight,t.clientHeight)},scrollY:function(){return t.scrollTop}}}(t)}function n(t,s,e){var n,o=function(){var n=!1;try{var t={get passive(){n=!0}};window.addEventListener("test",t,t),window.removeEventListener("test",t,t)}catch(t){n=!1}return n}(),i=!1,r=d(t),l=r.scrollY(),a={};function c(){var t=Math.round(r.scrollY()),n=r.height(),o=r.scrollHeight();a.scrollY=t,a.lastScrollY=l,a.direction=l<t?"down":"up",a.distance=Math.abs(t-l),a.isOutOfBounds=t<0||o<t+n,a.top=t<=s.offset,a.bottom=o<=t+n,a.toleranceExceeded=a.distance>s.tolerance[a.direction],e(a),l=t,i=!1}function h(){i||(i=!0,n=requestAnimationFrame(c))}var u=!!o&&{passive:!0,capture:!1};return t.addEventListener("scroll",h,u),c(),{destroy:function(){cancelAnimationFrame(n),t.removeEventListener("scroll",h,u)}}}function o(t,n){n=n||{},Object.assign(this,o.options,n),this.classes=Object.assign({},o.options.classes,n.classes),this.elem=t,this.tolerance=function(t){return t===Object(t)?t:{down:t,up:t}}(this.tolerance),this.initialised=!1,this.frozen=!1}return o.prototype={constructor:o,init:function(){return o.cutsTheMustard&&!this.initialised&&(this.addClass("initial"),this.initialised=!0,setTimeout(function(t){t.scrollTracker=n(t.scroller,{offset:t.offset,tolerance:t.tolerance},t.update.bind(t))},100,this)),this},destroy:function(){this.initialised=!1,Object.keys(this.classes).forEach(this.removeClass,this),this.scrollTracker.destroy()},unpin:function(){!this.hasClass("pinned")&&this.hasClass("unpinned")||(this.addClass("unpinned"),this.removeClass("pinned"),this.onUnpin&&this.onUnpin.call(this))},pin:function(){this.hasClass("unpinned")&&(this.addClass("pinned"),this.removeClass("unpinned"),this.onPin&&this.onPin.call(this))},freeze:function(){this.frozen=!0,this.addClass("frozen")},unfreeze:function(){this.frozen=!1,this.removeClass("frozen")},top:function(){this.hasClass("top")||(this.addClass("top"),this.removeClass("notTop"),this.onTop&&this.onTop.call(this))},notTop:function(){this.hasClass("notTop")||(this.addClass("notTop"),this.removeClass("top"),this.onNotTop&&this.onNotTop.call(this))},bottom:function(){this.hasClass("bottom")||(this.addClass("bottom"),this.removeClass("notBottom"),this.onBottom&&this.onBottom.call(this))},notBottom:function(){this.hasClass("notBottom")||(this.addClass("notBottom"),this.removeClass("bottom"),this.onNotBottom&&this.onNotBottom.call(this))},shouldUnpin:function(t){return"down"===t.direction&&!t.top&&t.toleranceExceeded},shouldPin:function(t){return"up"===t.direction&&t.toleranceExceeded||t.top},addClass:function(t){this.elem.classList.add.apply(this.elem.classList,this.classes[t].split(" "))},removeClass:function(t){this.elem.classList.remove.apply(this.elem.classList,this.classes[t].split(" "))},hasClass:function(t){return this.classes[t].split(" ").every(function(t){return this.classList.contains(t)},this.elem)},update:function(t){t.isOutOfBounds||!0!==this.frozen&&(t.top?this.top():this.notTop(),t.bottom?this.bottom():this.notBottom(),this.shouldUnpin(t)?this.unpin():this.shouldPin(t)&&this.pin())}},o.options={tolerance:{up:0,down:0},offset:0,scroller:t()?window:null,classes:{frozen:"headroom--frozen",pinned:"headroom--pinned",unpinned:"headroom--unpinned",top:"headroom--top",notTop:"headroom--not-top",bottom:"headroom--bottom",notBottom:"headroom--not-bottom",initial:"headroom"}},o.cutsTheMustard=!!(t()&&function(){}.bind&&"classList"in document.documentElement&&Object.assign&&Object.keys&&requestAnimationFrame),o});
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+/*!
+ * headroom.js v0.9.4 - Give your page some headroom. Hide your header until you need it
+ * Copyright (c) 2017 Nick Williams - http://wicky.nillia.ms/headroom.js
+ * License: MIT
+ */
+
+!function(a){a&&(a.fn.headroom=function(b){return this.each(function(){var c=a(this),d=c.data("headroom"),e="object"==typeof b&&b;e=a.extend(!0,{},Headroom.options,e),d||(d=new Headroom(this,e),d.init(),c.data("headroom",d)),"string"==typeof b&&(d[b](),"destroy"===b&&c.removeData("headroom"))})},a("[data-headroom]").each(function(){var b=a(this);b.headroom(b.data())}))}(window.Zepto||window.jQuery);
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+++ b/docs/deps/search-1.0.0/autocomplete.jquery.min.js
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+/*!
+ * autocomplete.js 0.38.0
+ * https://github.com/algolia/autocomplete.js
+ * Copyright 2020 Algolia, Inc. and other contributors; Licensed MIT
+ */
+!function(a){function b(d){if(c[d])return c[d].exports;var e=c[d]={exports:{},id:d,loaded:!1};return a[d].call(e.exports,e,e.exports,b),e.loaded=!0,e.exports}var c={};b.m=a,b.c=c,b.p="",b(0)}([function(a,b,c){"use strict";a.exports=c(1)},function(a,b,c){"use strict";var d=c(2),e=c(3);d.element=e;var f=c(4);f.isArray=e.isArray,f.isFunction=e.isFunction,f.isObject=e.isPlainObject,f.bind=e.proxy,f.each=function(a,b){function c(a,c){return b(c,a)}e.each(a,c)},f.map=e.map,f.mixin=e.extend,f.Event=e.Event;var g,h,i,j=c(5),k=c(6);g=e.fn.autocomplete,h="aaAutocomplete",i={initialize:function(a,b){function c(){var c,d=e(this),f=new k({el:d});c=new j({input:d,eventBus:f,dropdownMenuContainer:a.dropdownMenuContainer,hint:void 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f=document.createElement("div");f.appendChild(document.createTextNode(c));var g=document.createElement("div");return g.appendChild(document.createTextNode(a)),g.innerHTML.replace(RegExp(d(e.innerHTML),"g"),b).replace(RegExp(d(f.innerHTML),"g"),c)}}},function(a,b,c){"use strict";function d(a){var b,c;if(a=a||{},a.input||i.error("missing input"),this.isActivated=!1,this.debug=!!a.debug,this.autoselect=!!a.autoselect,this.autoselectOnBlur=!!a.autoselectOnBlur,this.openOnFocus=!!a.openOnFocus,this.minLength=i.isNumber(a.minLength)?a.minLength:1,this.autoWidth=void 0===a.autoWidth||!!a.autoWidth,this.clearOnSelected=!!a.clearOnSelected,this.tabAutocomplete=void 0===a.tabAutocomplete||!!a.tabAutocomplete,a.hint=!!a.hint,a.hint&&a.appendTo)throw new Error("[autocomplete.js] hint and appendTo options can't be used at the same time");this.css=a.css=i.mixin({},o,a.appendTo?o.appendTo:{}),this.cssClasses=a.cssClasses=i.mixin({},o.defaultClasses,a.cssClasses||{}),this.cssClasses.prefix=a.cssClasses.formattedPrefix=i.formatPrefix(this.cssClasses.prefix,this.cssClasses.noPrefix),this.listboxId=a.listboxId=[this.cssClasses.root,"listbox",i.getUniqueId()].join("-");var f=e(a);this.$node=f.wrapper;var g=this.$input=f.input;b=f.menu,c=f.hint,a.dropdownMenuContainer&&j.element(a.dropdownMenuContainer).css("position","relative").append(b.css("top","0")),g.on("blur.aa",function(a){var c=document.activeElement;i.isMsie()&&(b[0]===c||b[0].contains(c))&&(a.preventDefault(),a.stopImmediatePropagation(),i.defer(function(){g.focus()}))}),b.on("mousedown.aa",function(a){a.preventDefault()}),this.eventBus=a.eventBus||new k({el:g}),this.dropdown=new d.Dropdown({appendTo:a.appendTo,wrapper:this.$node,menu:b,datasets:a.datasets,templates:a.templates,cssClasses:a.cssClasses,minLength:this.minLength}).onSync("suggestionClicked",this._onSuggestionClicked,this).onSync("cursorMoved",this._onCursorMoved,this).onSync("cursorRemoved",this._onCursorRemoved,this).onSync("opened",this._onOpened,this).onSync("closed",this._onClosed,this).onSync("shown",this._onShown,this).onSync("empty",this._onEmpty,this).onSync("redrawn",this._onRedrawn,this).onAsync("datasetRendered",this._onDatasetRendered,this),this.input=new 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g=n.dropdown.replace("%PREFIX%",a.cssClasses.prefix).replace("%DROPDOWN_MENU%",a.cssClasses.dropdownMenu);d=j.element(g).css(a.css.dropdown).attr({role:"listbox",id:a.listboxId}),a.templates&&a.templates.dropdownMenu&&d.html(i.templatify(a.templates.dropdownMenu)()),e=b.clone().css(a.css.hint).css(f(b)),e.val("").addClass(i.className(a.cssClasses.prefix,a.cssClasses.hint,!0)).removeAttr("id name placeholder required").prop("readonly",!0).attr({"aria-hidden":"true",autocomplete:"off",spellcheck:"false",tabindex:-1}),e.removeData&&e.removeData(),b.data(h,{"aria-autocomplete":b.attr("aria-autocomplete"),"aria-expanded":b.attr("aria-expanded"),"aria-owns":b.attr("aria-owns"),autocomplete:b.attr("autocomplete"),dir:b.attr("dir"),role:b.attr("role"),spellcheck:b.attr("spellcheck"),style:b.attr("style"),type:b.attr("type")}),b.addClass(i.className(a.cssClasses.prefix,a.cssClasses.input,!0)).attr({autocomplete:"off",spellcheck:!1,role:"combobox","aria-autocomplete":a.datasets&&a.datasets[0]&&a.datasets[0].displayKey?"both":"list","aria-expanded":"false","aria-label":a.ariaLabel,"aria-owns":a.listboxId}).css(a.hint?a.css.input:a.css.inputWithNoHint);try{b.attr("dir")||b.attr("dir","auto")}catch(a){}return c=a.appendTo?c.appendTo(j.element(a.appendTo).eq(0)).eq(0):b.wrap(c).parent(),c.prepend(a.hint?e:null).append(d),{wrapper:c,input:b,hint:e,menu:d}}function f(a){return{backgroundAttachment:a.css("background-attachment"),backgroundClip:a.css("background-clip"),backgroundColor:a.css("background-color"),backgroundImage:a.css("background-image"),backgroundOrigin:a.css("background-origin"),backgroundPosition:a.css("background-position"),backgroundRepeat:a.css("background-repeat"),backgroundSize:a.css("background-size")}}function g(a,b){var c=a.find(i.className(b.prefix,b.input));i.each(c.data(h),function(a,b){void 0===a?c.removeAttr(b):c.attr(b,a)}),c.detach().removeClass(i.className(b.prefix,b.input,!0)).insertAfter(a),c.removeData&&c.removeData(h),a.remove()}var h="aaAttrs",i=c(4),j=c(2),k=c(6),l=c(7),m=c(16),n=c(18),o=c(19);i.mixin(d.prototype,{_bindKeyboardShortcuts:function(a){if(a.keyboardShortcuts){var b=this.$input,c=[];i.each(a.keyboardShortcuts,function(a){"string"==typeof a&&(a=a.toUpperCase().charCodeAt(0)),c.push(a)}),j.element(document).keydown(function(a){var d=a.target||a.srcElement,e=d.tagName;if(!d.isContentEditable&&"INPUT"!==e&&"SELECT"!==e&&"TEXTAREA"!==e){var f=a.which||a.keyCode;c.indexOf(f)!==-1&&(b.focus(),a.stopPropagation(),a.preventDefault())}})}},_onSuggestionClicked:function(a,b){var c,d={selectionMethod:"click"};(c=this.dropdown.getDatumForSuggestion(b))&&this._select(c,d)},_onCursorMoved:function(a,b){var c=this.dropdown.getDatumForCursor(),d=this.dropdown.getCurrentCursor().attr("id");this.input.setActiveDescendant(d),c&&(b&&this.input.setInputValue(c.value,!0),this.eventBus.trigger("cursorchanged",c.raw,c.datasetName))},_onCursorRemoved:function(){this.input.resetInputValue(),this._updateHint(),this.eventBus.trigger("cursorremoved")},_onDatasetRendered:function(){this._updateHint(),this.eventBus.trigger("updated")},_onOpened:function(){this._updateHint(),this.input.expand(),this.eventBus.trigger("opened")},_onEmpty:function(){this.eventBus.trigger("empty")},_onRedrawn:function(){this.$node.css("top","0px"),this.$node.css("left","0px");var a=this.$input[0].getBoundingClientRect();this.autoWidth&&this.$node.css("width",a.width+"px");var b=this.$node[0].getBoundingClientRect(),c=a.bottom-b.top;this.$node.css("top",c+"px");var d=a.left-b.left;this.$node.css("left",d+"px"),this.eventBus.trigger("redrawn")},_onShown:function(){this.eventBus.trigger("shown"),this.autoselect&&this.dropdown.cursorTopSuggestion()},_onClosed:function(){this.input.clearHint(),this.input.removeActiveDescendant(),this.input.collapse(),this.eventBus.trigger("closed")},_onFocused:function(){if(this.isActivated=!0,this.openOnFocus){var a=this.input.getQuery();a.length>=this.minLength?this.dropdown.update(a):this.dropdown.empty(),this.dropdown.open()}},_onBlurred:function(){var a,b;a=this.dropdown.getDatumForCursor(),b=this.dropdown.getDatumForTopSuggestion();var c={selectionMethod:"blur"};this.debug||(this.autoselectOnBlur&&a?this._select(a,c):this.autoselectOnBlur&&b?this._select(b,c):(this.isActivated=!1,this.dropdown.empty(),this.dropdown.close()))},_onEnterKeyed:function(a,b){var c,d;c=this.dropdown.getDatumForCursor(),d=this.dropdown.getDatumForTopSuggestion();var e={selectionMethod:"enterKey"};c?(this._select(c,e),b.preventDefault()):this.autoselect&&d&&(this._select(d,e),b.preventDefault())},_onTabKeyed:function(a,b){if(!this.tabAutocomplete)return void this.dropdown.close();var c,d={selectionMethod:"tabKey"};(c=this.dropdown.getDatumForCursor())?(this._select(c,d),b.preventDefault()):this._autocomplete(!0)},_onEscKeyed:function(){this.dropdown.close(),this.input.resetInputValue()},_onUpKeyed:function(){var a=this.input.getQuery();this.dropdown.isEmpty&&a.length>=this.minLength?this.dropdown.update(a):this.dropdown.moveCursorUp(),this.dropdown.open()},_onDownKeyed:function(){var a=this.input.getQuery();this.dropdown.isEmpty&&a.length>=this.minLength?this.dropdown.update(a):this.dropdown.moveCursorDown(),this.dropdown.open()},_onLeftKeyed:function(){"rtl"===this.dir&&this._autocomplete()},_onRightKeyed:function(){"ltr"===this.dir&&this._autocomplete()},_onQueryChanged:function(a,b){this.input.clearHintIfInvalid(),b.length>=this.minLength?this.dropdown.update(b):this.dropdown.empty(),this.dropdown.open(),this._setLanguageDirection()},_onWhitespaceChanged:function(){this._updateHint(),this.dropdown.open()},_setLanguageDirection:function(){var a=this.input.getLanguageDirection();this.dir!==a&&(this.dir=a,this.$node.css("direction",a),this.dropdown.setLanguageDirection(a))},_updateHint:function(){var a,b,c,d,e,f;a=this.dropdown.getDatumForTopSuggestion(),a&&this.dropdown.isVisible()&&!this.input.hasOverflow()?(b=this.input.getInputValue(),c=l.normalizeQuery(b),d=i.escapeRegExChars(c),e=new 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a=this.input.getInputValue();a.length>=this.minLength?this.dropdown.update(a):this.dropdown.empty()}this.dropdown.open()},close:function(){this.dropdown.close()},setVal:function(a){a=i.toStr(a),this.isActivated?this.input.setInputValue(a):(this.input.setQuery(a),this.input.setInputValue(a,!0)),this._setLanguageDirection()},getVal:function(){return this.input.getQuery()},destroy:function(){this.input.destroy(),this.dropdown.destroy(),g(this.$node,this.cssClasses),this.$node=null},getWrapper:function(){return this.dropdown.$container[0]}}),d.Dropdown=m,d.Input=l,d.sources=c(20),a.exports=d},function(a,b,c){"use strict";function d(a){a&&a.el||e.error("EventBus initialized without el"),this.$el=f.element(a.el)}var e=c(4),f=c(2);e.mixin(d.prototype,{trigger:function(a,b,c,d){var f=e.Event("autocomplete:"+a);return this.$el.trigger(f,[b,c,d]),f}}),a.exports=d},function(a,b,c){"use strict";function d(a){var b,c,d,f,g=this;a=a||{},a.input||i.error("input is 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b=h[a.which||a.keyCode];this._managePreventDefault(b,a),b&&this._shouldTrigger(b,a)&&this.trigger(b+"Keyed",a)},_onInput:function(){this._checkInputValue()},_managePreventDefault:function(a,b){var c,d,e;switch(a){case"tab":d=this.getHint(),e=this.getInputValue(),c=d&&d!==e&&!g(b);break;case"up":case"down":c=!g(b);break;default:c=!1}c&&b.preventDefault()},_shouldTrigger:function(a,b){var c;switch(a){case"tab":c=!g(b);break;default:c=!0}return c},_checkInputValue:function(){var a,b,c;a=this.getInputValue(),b=f(a,this.query),c=!(!b||!this.query)&&this.query.length!==a.length,this.query=a,b?c&&this.trigger("whitespaceChanged",this.query):this.trigger("queryChanged",this.query)},focus:function(){this.$input.focus()},blur:function(){this.$input.blur()},getQuery:function(){return this.query},setQuery:function(a){this.query=a},getInputValue:function(){return this.$input.val()},setInputValue:function(a,b){void 0===a&&(a=this.query),this.$input.val(a),b?this.clearHint():this._checkInputValue()},expand:function(){this.$input.attr("aria-expanded","true")},collapse:function(){this.$input.attr("aria-expanded","false")},setActiveDescendant:function(a){this.$input.attr("aria-activedescendant",a)},removeActiveDescendant:function(){this.$input.removeAttr("aria-activedescendant")},resetInputValue:function(){this.setInputValue(this.query,!0)},getHint:function(){return this.$hint.val()},setHint:function(a){this.$hint.val(a)},clearHint:function(){this.setHint("")},clearHintIfInvalid:function(){var a,b,c,d;a=this.getInputValue(),b=this.getHint(),c=a!==b&&0===b.indexOf(a),(d=""!==a&&c&&!this.hasOverflow())||this.clearHint()},getLanguageDirection:function(){return(this.$input.css("direction")||"ltr").toLowerCase()},hasOverflow:function(){var a=this.$input.width()-2;return this.$overflowHelper.text(this.getInputValue()),this.$overflowHelper.width()>=a},isCursorAtEnd:function(){var a,b,c;return 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\ No newline at end of file
diff --git a/docs/deps/search-1.0.0/fuse.min.js b/docs/deps/search-1.0.0/fuse.min.js
new file mode 100644
index 0000000..7def598
--- /dev/null
+++ b/docs/deps/search-1.0.0/fuse.min.js
@@ -0,0 +1,9 @@
+/**
+ * Fuse.js v6.4.6 - Lightweight fuzzy-search (http://fusejs.io)
+ *
+ * Copyright (c) 2021 Kiro Risk (http://kiro.me)
+ * All Rights Reserved. Apache Software License 2.0
+ *
+ * http://www.apache.org/licenses/LICENSE-2.0
+ */
+var e,t;e=this,t=function(){"use strict";function e(t){return(e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(t)}function t(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}function n(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}function r(e,t,r){return t&&n(e.prototype,t),r&&n(e,r),e}function i(e,t,n){return t in e?Object.defineProperty(e,t,{value:n,enumerable:!0,configurable:!0,writable:!0}):e[t]=n,e}function o(e,t){var n=Object.keys(e);if(Object.getOwnPropertySymbols){var r=Object.getOwnPropertySymbols(e);t&&(r=r.filter((function(t){return Object.getOwnPropertyDescriptor(e,t).enumerable}))),n.push.apply(n,r)}return n}function c(e){for(var t=1;t<arguments.length;t++){var 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\ No newline at end of file
diff --git a/docs/deps/search-1.0.0/mark.min.js b/docs/deps/search-1.0.0/mark.min.js
new file mode 100644
index 0000000..1eea053
--- /dev/null
+++ b/docs/deps/search-1.0.0/mark.min.js
@@ -0,0 +1,7 @@
+/*!***************************************************
+* mark.js v8.11.1
+* https://markjs.io/
+* Copyright (c) 2014–2018, Julian Kühnel
+* Released under the MIT license https://git.io/vwTVl
+*****************************************************/
+!function(e,t){"object"==typeof exports&&"undefined"!=typeof module?module.exports=t():"function"==typeof define&&define.amd?define(t):e.Mark=t()}(this,function(){"use strict";var e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e},t=function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")},n=function(){function e(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(t,n,r){return n&&e(t.prototype,n),r&&e(t,r),t}}(),r=Object.assign||function(e){for(var t=1;t<arguments.length;t++){var n=arguments[t];for(var r in n)Object.prototype.hasOwnProperty.call(n,r)&&(e[r]=n[r])}return e},i=function(){function e(n){var r=!(arguments.length>1&&void 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diff --git a/docs/index.html b/docs/index.html
index 37a0320..6738485 100644
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@@ -5,73 +5,61 @@
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+<link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
+<script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/Roboto-0.4.9/font.css" rel="stylesheet">
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+<link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet">
+<link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet">
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+
     <a class="navbar-brand me-2" href="index.html">CSHstats</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.0.33</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.0.34</small>
+
 
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+    <li><a class="dropdown-item" href="articles/S7_cnn.html">S7 Neural net concepts and applications</a></li>
+  </ul>
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-     
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-</li>
+<ul class="navbar-nav">
+<li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="search.json">
+</form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/vjcitn/CSHstats/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
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+
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 </nav><div class="container template-home">
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@@ -79,7 +67,6 @@
 <div class="page-header"><h1 id="cshstats">CSHstats<a class="anchor" aria-label="anchor" href="#cshstats"></a>
 </h1></div>
 <p>R vignettes/pkgdown for elementary statistics for a summer course</p>
-<p>DRAFT! Very preliminary as of 19 May 2022</p>
 <p>One view of the conceptual scheme of the course has three main vertices:</p>
 <p><img src="reference/figures/triangle.png" width="500"></p>
 <p>Most students start at the lower left vertex and need to move along the bottom edge to work with high-dimensional data generated by sequencing technologies.</p>
@@ -89,8 +76,10 @@
 <li>Exploratory data analysis and visualization</li>
 <li>Hypothesis testing</li>
 <li>Linear models</li>
+<li>Ontology as a branch of information science</li>
+<li>Brief introduction to convolutional neural nets</li>
 </ul>
-<p>MultiAssayExperiment applications with SingleCellMultimodal (for convenience)</p>
+<p>TBD: MultiAssayExperiment applications with SingleCellMultimodal (for convenience)</p>
 <p><a href="https://bioconductor.org/packages/release/data/experiment/vignettes/SingleCellMultiModal/inst/doc/CITEseq.html" class="external-link">CITEseq</a></p>
 <p><a href="https://bioconductor.org/packages/release/data/experiment/vignettes/SingleCellMultiModal/inst/doc/scMultiome.html" class="external-link">TENx MultiOme</a></p>
 <p><a href="https://bioconductor.org/packages/release/data/experiment/vignettes/SingleCellMultiModal/inst/doc/seqFISH.html" class="external-link">seqFISH</a></p>
@@ -132,21 +121,19 @@ <h2 data-toc-skip>Developers</h2>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p>
-<p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
 </div>
 
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-  <p></p>
-<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
 </div>
 
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 </div>
 
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diff --git a/docs/katex-auto.js b/docs/katex-auto.js
new file mode 100644
index 0000000..20651d9
--- /dev/null
+++ b/docs/katex-auto.js
@@ -0,0 +1,14 @@
+// https://github.com/jgm/pandoc/blob/29fa97ab96b8e2d62d48326e1b949a71dc41f47a/src/Text/Pandoc/Writers/HTML.hs#L332-L345
+document.addEventListener("DOMContentLoaded", function () {
+  var mathElements = document.getElementsByClassName("math");
+  var macros = [];
+  for (var i = 0; i < mathElements.length; i++) {
+    var texText = mathElements[i].firstChild;
+    if (mathElements[i].tagName == "SPAN") {
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+        displayMode: mathElements[i].classList.contains("display"),
+        throwOnError: false,
+        macros: macros,
+        fleqn: false
+      });
+    }}});
diff --git a/docs/lightswitch.js b/docs/lightswitch.js
new file mode 100644
index 0000000..9467125
--- /dev/null
+++ b/docs/lightswitch.js
@@ -0,0 +1,85 @@
+
+/*!
+ * Color mode toggler for Bootstrap's docs (https://getbootstrap.com/)
+ * Copyright 2011-2023 The Bootstrap Authors
+ * Licensed under the Creative Commons Attribution 3.0 Unported License.
+ * Updates for {pkgdown} by the {bslib} authors, also licensed under CC-BY-3.0.
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+
+const getStoredTheme = () => localStorage.getItem('theme')
+const setStoredTheme = theme => localStorage.setItem('theme', theme)
+
+const getPreferredTheme = () => {
+  const storedTheme = getStoredTheme()
+  if (storedTheme) {
+    return storedTheme
+  }
+
+  return window.matchMedia('(prefers-color-scheme: dark)').matches ? 'dark' : 'light'
+}
+
+const setTheme = theme => {
+  if (theme === 'auto') {
+    document.documentElement.setAttribute('data-bs-theme', (window.matchMedia('(prefers-color-scheme: dark)').matches ? 'dark' : 'light'))
+  } else {
+    document.documentElement.setAttribute('data-bs-theme', theme)
+  }
+}
+
+function bsSetupThemeToggle () {
+  'use strict'
+
+  const showActiveTheme = (theme, focus = false) => {
+    var activeLabel, activeIcon;
+
+    document.querySelectorAll('[data-bs-theme-value]').forEach(element => {
+      const buttonTheme = element.getAttribute('data-bs-theme-value')
+      const isActive = buttonTheme == theme
+      
+      element.classList.toggle('active', isActive)
+      element.setAttribute('aria-pressed', isActive)
+
+      if (isActive) {
+        activeLabel = element.textContent;
+        activeIcon = element.querySelector('span').classList.value;
+      }
+    })
+
+    const themeSwitcher = document.querySelector('#dropdown-lightswitch')
+    if (!themeSwitcher) {
+      return
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+
+    themeSwitcher.setAttribute('aria-label', activeLabel)
+    themeSwitcher.querySelector('span').classList.value = activeIcon;
+
+    if (focus) {
+      themeSwitcher.focus()
+    }
+  }
+
+  window.matchMedia('(prefers-color-scheme: dark)').addEventListener('change', () => {
+    const storedTheme = getStoredTheme()
+    if (storedTheme !== 'light' && storedTheme !== 'dark') {
+      setTheme(getPreferredTheme())
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+  window.addEventListener('DOMContentLoaded', () => {
+    showActiveTheme(getPreferredTheme())
+
+    document
+      .querySelectorAll('[data-bs-theme-value]')
+      .forEach(toggle => {
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+          const theme = toggle.getAttribute('data-bs-theme-value')
+          setTheme(theme)
+          setStoredTheme(theme)
+          showActiveTheme(theme, true)
+        })
+      })
+  })
+}
+
+setTheme(getPreferredTheme());
+bsSetupThemeToggle();
diff --git a/docs/pkgdown.js b/docs/pkgdown.js
index 5fccd9c..1a99c65 100644
--- a/docs/pkgdown.js
+++ b/docs/pkgdown.js
@@ -30,10 +30,10 @@
   /* Clipboard --------------------------*/
 
   function changeTooltipMessage(element, msg) {
-    var tooltipOriginalTitle=element.getAttribute('data-original-title');
-    element.setAttribute('data-original-title', msg);
+    var tooltipOriginalTitle=element.getAttribute('data-bs-original-title');
+    element.setAttribute('data-bs-original-title', msg);
     $(element).tooltip('show');
-    element.setAttribute('data-original-title', tooltipOriginalTitle);
+    element.setAttribute('data-bs-original-title', tooltipOriginalTitle);
   }
 
   if(ClipboardJS.isSupported()) {
@@ -60,7 +60,7 @@
         e.clearSelection();
       });
 
-      clipboard.on('error', function() {
+      clipboard.on('error', function(e) {
         changeTooltipMessage(e.trigger,'Press Ctrl+C or Command+C to copy');
       });
 
@@ -153,4 +153,10 @@ async function searchFuse(query, callback) {
   });
 })(window.jQuery || window.$)
 
-
+document.addEventListener('keydown', function(event) {
+  // Check if the pressed key is '/'
+  if (event.key === '/') {
+    event.preventDefault();  // Prevent any default action associated with the '/' key
+    document.getElementById('search-input').focus();  // Set focus to the search input
+  }
+});
diff --git a/docs/pkgdown.yml b/docs/pkgdown.yml
index 61a84f4..c9bb9b4 100644
--- a/docs/pkgdown.yml
+++ b/docs/pkgdown.yml
@@ -1,5 +1,5 @@
-pandoc: '2.5'
-pkgdown: 2.0.7
+pandoc: '2.13'
+pkgdown: 2.1.1
 pkgdown_sha: ~
 articles:
   S1_probability: S1_probability.html
@@ -13,5 +13,4 @@ articles:
   S5b_nonlin: S5b_nonlin.html
   S6_hca_onto: S6_hca_onto.html
   S7_cnn: S7_cnn.html
-last_built: 2023-07-11T14:36Z
-
+last_built: 2024-11-02T11:37Z
diff --git a/docs/reference/accex.html b/docs/reference/accex.html
index 1b7bcfe..8d635f7 100644
--- a/docs/reference/accex.html
+++ b/docs/reference/accex.html
@@ -1,59 +1,47 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="MultiAssayExperiment instance for ACC"><title>MultiAssayExperiment instance for ACC — accex • CSHstats</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.2.2/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.2.2/bootstrap.bundle.min.js"></script><link href="../deps/Roboto-0.4.6/font.css" rel="stylesheet"><link href="../deps/Courier_Prime-0.4.6/font.css" rel="stylesheet"><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="MultiAssayExperiment instance for ACC — accex"><meta property="og:description" content="MultiAssayExperiment instance for ACC"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]--></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>MultiAssayExperiment instance for ACC — accex • CSHstats</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/Roboto-0.4.9/font.css" rel="stylesheet"><link href="../deps/Courier_Prime-0.4.9/font.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="MultiAssayExperiment instance for ACC — accex"><meta name="description" content="MultiAssayExperiment instance for ACC"><meta property="og:description" content="MultiAssayExperiment instance for ACC"></head><body>
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-    
 
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+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">CSHstats</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.0.33</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.0.34</small>
+
 
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+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
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+    <li><a class="dropdown-item" href="../articles/S1b_hyper.html">S1a: A look at the hypergeometric distribution</a></li>
+    <li><a class="dropdown-item" href="../articles/S2_EDA.html">S2_EDA: Exploratory data analysis and visualization</a></li>
+    <li><a class="dropdown-item" href="../articles/S2a_PCAelem.html">S2a: Elements of PCA</a></li>
+    <li><a class="dropdown-item" href="../articles/S3_distclust.html">S3: Distances, clustering</a></li>
+    <li><a class="dropdown-item" href="../articles/S4_hypothesis_testing.html">S4_inference: Definitions and exercises</a></li>
+    <li><a class="dropdown-item" href="../articles/S5_linear_models.html">S5_inference: FDR, linear models, and GLMs</a></li>
+    <li><a class="dropdown-item" href="../articles/S5a_lmdiagnostics.html">S5a: Diagnostics of a differential gene expression exercise</a></li>
+    <li><a class="dropdown-item" href="../articles/S5b_nonlin.html">S5b: hypothesis testing in nonlinear regression</a></li>
+    <li><a class="dropdown-item" href="../articles/S6_hca_onto.html">S6 HCA, ontologies, shiny</a></li>
+    <li><a class="dropdown-item" href="../articles/S7_cnn.html">S7 Neural net concepts and applications</a></li>
+  </ul></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/vjcitn/CSHstats/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul></div>
 
-    
+
   </div>
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>MultiAssayExperiment instance for ACC</h1>
+
+      <h1>MultiAssayExperiment instance for ACC</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/data.R" class="external-link"><code>R/data.R</code></a></small>
       <div class="d-none name"><code>accex.Rd</code></div>
     </div>
@@ -72,23 +60,23 @@ <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a><
     <p>MultiAssayExperiment</p>
     </div>
 
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
 </div>
 
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diff --git a/docs/reference/build_deck.html b/docs/reference/build_deck.html
index 0d963ac..fa92adb 100644
--- a/docs/reference/build_deck.html
+++ b/docs/reference/build_deck.html
@@ -1,59 +1,47 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="make a deck of cards with 52 elements and unicode symbols for suits"><title>make a deck of cards with 52 elements and unicode symbols for suits — build_deck • CSHstats</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.2.2/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.2.2/bootstrap.bundle.min.js"></script><link href="../deps/Roboto-0.4.6/font.css" rel="stylesheet"><link href="../deps/Courier_Prime-0.4.6/font.css" rel="stylesheet"><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="make a deck of cards with 52 elements and unicode symbols for suits — build_deck"><meta property="og:description" content="make a deck of cards with 52 elements and unicode symbols for suits"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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@@ -72,23 +60,23 @@ <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a><
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       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/data.R" class="external-link"><code>R/data.R</code></a></small>
       <div class="d-none name"><code>doubsim2.Rd</code></div>
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@@ -72,23 +60,23 @@ <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a><
     <p>character vector</p>
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@@ -72,23 +60,23 @@ <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a><
     <p>character vector</p>
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+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
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-      <img src="" class="logo" alt=""><h1>RNASeq2GeneNorm measures for EGR1 from TCGA ACC samples</h1>
+
+      <h1>RNASeq2GeneNorm measures for EGR1 from TCGA ACC samples</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/data.R" class="external-link"><code>R/data.R</code></a></small>
       <div class="d-none name"><code>egr1_ex.Rd</code></div>
     </div>
@@ -72,23 +60,23 @@ <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a><
     <p>numeric vector</p>
     </div>
 
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
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     </nav></aside></div>
 
 
     <footer><div class="pkgdown-footer-left">
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@@ -1,59 +1,47 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="get faces of a collection of cards"><title>get faces of a collection of cards — faces • CSHstats</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.2.2/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.2.2/bootstrap.bundle.min.js"></script><link href="../deps/Roboto-0.4.6/font.css" rel="stylesheet"><link href="../deps/Courier_Prime-0.4.6/font.css" rel="stylesheet"><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="get faces of a collection of cards — faces"><meta property="og:description" content="get faces of a collection of cards"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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-      <img src="" class="logo" alt=""><h1>get faces of a collection of cards</h1>
+
+      <h1>get faces of a collection of cards</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/build_deck.R" class="external-link"><code>R/build_deck.R</code></a></small>
       <div class="d-none name"><code>faces.Rd</code></div>
     </div>
@@ -69,7 +57,9 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>x</dt>
+
+
+<dl><dt id="arg-x">x<a class="anchor" aria-label="anchor" href="#arg-x"></a></dt>
 <dd><p>a card from a deck made by `build_deck`</p></dd>
 
 </dl></div>
@@ -83,23 +73,23 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-out co"><span class="r-pr">#&gt;</span> [1] "2" "3"</span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
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+    <li><a class="dropdown-item" href="../articles/S6_hca_onto.html">S6 HCA, ontologies, shiny</a></li>
+    <li><a class="dropdown-item" href="../articles/S7_cnn.html">S7 Neural net concepts and applications</a></li>
+  </ul></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/vjcitn/CSHstats/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul></div>
 
-    
+
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 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>test for full house</h1>
+
+      <h1>test for full house</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/poker.R" class="external-link"><code>R/poker.R</code></a></small>
       <div class="d-none name"><code>full_house.Rd</code></div>
     </div>
@@ -69,7 +57,9 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>x</dt>
+
+
+<dl><dt id="arg-x">x<a class="anchor" aria-label="anchor" href="#arg-x"></a></dt>
 <dd><p>a vector of cards</p></dd>
 
 </dl></div>
@@ -89,23 +79,23 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-out co"><span class="r-pr">#&gt;</span> [1] FALSE</span>
 </code></pre></div>
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-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
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     <footer><div class="pkgdown-footer-left">
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+  <p>Developed by Vince Carey.</p>
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-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
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index 1431abe..07e88f9 100644
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+++ b/docs/reference/gtex_exc_chr20_b38.html
@@ -1,59 +1,47 @@
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 </nav><div class="container template-reference-topic">
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-      <img src="" class="logo" alt=""><h1>data.frame with GTEx lung eQTL data and metadata, a selection from chr20</h1>
+
+      <h1>data.frame with GTEx lung eQTL data and metadata, a selection from chr20</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/data.R" class="external-link"><code>R/data.R</code></a></small>
       <div class="d-none name"><code>gtex_exc_chr20_b38.Rd</code></div>
     </div>
@@ -72,23 +60,23 @@ <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a><
     <p>data.frame</p>
     </div>
 
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
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-      <img src="" class="logo" alt=""><h1>Function reference</h1>
+
+      <h1>Package index</h1>
     </div>
 
     <div class="section level2">
       <h2 id="all-functions">All functions<a class="anchor" aria-label="anchor" href="#all-functions"></a></h2>
-      
-      
 
-      
-    </div><div id="" class="section level2">
-      
-      
-      
+
+
+
+    </div><div class="section level2">
+
+
+
 
       <dl><dt>
-          
-          <code><a href="accex.html">accex</a></code> 
+
+          <code><a href="accex.html">accex</a></code>
+
         </dt>
         <dd>MultiAssayExperiment instance for ACC</dd>
       </dl><dl><dt>
-          
-          <code><a href="build_deck.html">build_deck()</a></code> 
+
+          <code><a href="build_deck.html">build_deck()</a></code>
+
         </dt>
         <dd>make a deck of cards with 52 elements and unicode symbols for suits</dd>
       </dl><dl><dt>
-          
-          <code><a href="c50.html">c50</a></code> 
+
+          <code><a href="c50.html">c50</a></code>
+
         </dt>
         <dd>meaningless integers</dd>
       </dl><dl><dt>
-          
-          <code><a href="c5000.html">c5000</a></code> 
+
+          <code><a href="c5000.html">c5000</a></code>
+
         </dt>
         <dd>read depth for 5000 positions on pasilla chr4, from example(coverage) for GenomicAlignments</dd>
       </dl><dl><dt>
-          
-          <code><a href="de_results.html">de_results</a></code> 
+
+          <code><a href="de_results.html">de_results</a></code>
+
         </dt>
         <dd>topTable excerpt for SRP045638, see vGene</dd>
       </dl><dl><dt>
-          
-          <code><a href="doubsim.html">doubsim</a></code> 
+
+          <code><a href="doubsim.html">doubsim</a></code>
+
         </dt>
         <dd>simulated draws of top card from a shuffled deck of cards</dd>
       </dl><dl><dt>
-          
-          <code><a href="doubsim2.html">doubsim2</a></code> 
+
+          <code><a href="doubsim2.html">doubsim2</a></code>
+
         </dt>
-        <dd>simulated draws of top card from a shuffled  deck of cards</dd>
+        <dd>simulated draws of top card from a shuffled deck of cards</dd>
       </dl><dl><dt>
-          
-          <code><a href="doubsim3.html">doubsim3</a></code> 
+
+          <code><a href="doubsim3.html">doubsim3</a></code>
+
         </dt>
-        <dd>simulated draws of top card from a shuffled  deck of cards</dd>
+        <dd>simulated draws of top card from a shuffled deck of cards</dd>
       </dl><dl><dt>
-          
-          <code><a href="egr1_ex.html">egr1_ex</a></code> 
+
+          <code><a href="egr1_ex.html">egr1_ex</a></code>
+
         </dt>
         <dd>RNASeq2GeneNorm measures for EGR1 from TCGA ACC samples</dd>
       </dl><dl><dt>
-          
-          <code><a href="faces.html">faces()</a></code> 
+
+          <code><a href="faces.html">faces()</a></code>
+
         </dt>
         <dd>get faces of a collection of cards</dd>
       </dl><dl><dt>
-          
-          <code><a href="fos_ex.html">fos_ex</a></code> 
+
+          <code><a href="fos_ex.html">fos_ex</a></code>
+
         </dt>
         <dd>RNASeq2GeneNorm measures for FOS from TCGA ACC samples</dd>
       </dl><dl><dt>
-          
-          <code><a href="full_house.html">full_house()</a></code> 
+
+          <code><a href="full_house.html">full_house()</a></code>
+
         </dt>
         <dd>test for full house</dd>
       </dl><dl><dt>
-          
-          <code><a href="gtex_exc_chr20_b38.html">gtex_exc_chr20_b38</a></code> 
+
+          <code><a href="gtex_exc_chr20_b38.html">gtex_exc_chr20_b38</a></code>
+
         </dt>
         <dd>data.frame with GTEx lung eQTL data and metadata, a selection from chr20</dd>
       </dl><dl><dt>
-          
-          <code><a href="is_flush.html">is_flush()</a></code> 
+
+          <code><a href="is_flush.html">is_flush()</a></code>
+
         </dt>
         <dd>test for flush</dd>
       </dl><dl><dt>
-          
-          <code><a href="mod.html">mod</a></code> 
+
+          <code><a href="mod.html">mod</a></code>
+
         </dt>
         <dd>model matrix for SRP045638, see vGene</dd>
       </dl><dl><dt>
-          
-          <code><a href="nonlindat.html">nonlindat</a></code> 
+
+          <code><a href="nonlindat.html">nonlindat</a></code>
+
         </dt>
         <dd>a data frame with y and x in a sigmoidal relationship (with error and a covariate z)</dd>
       </dl><dl><dt>
-          
-          <code><a href="one_pair.html">one_pair()</a></code> 
+
+          <code><a href="one_pair.html">one_pair()</a></code>
+
         </dt>
         <dd>test for one pair</dd>
       </dl><dl><dt>
-          
-          <code><a href="queryCHCA.html">queryCHCA()</a></code> 
+
+          <code><a href="queryCHCA.html">queryCHCA()</a></code>
+
         </dt>
         <dd>use a snapshot of CuratedQueryAtlasR through duckdb</dd>
       </dl><dl><dt>
-          
-          <code><a href="suits.html">suits()</a></code> 
+
+          <code><a href="suits.html">suits()</a></code>
+
         </dt>
         <dd>get suits of a collection of cards</dd>
       </dl><dl><dt>
-          
-          <code><a href="two_pairs.html">two_pairs()</a></code> 
+
+          <code><a href="two_pairs.html">two_pairs()</a></code>
+
         </dt>
         <dd>test for two pairs</dd>
       </dl><dl><dt>
-          
-          <code><a href="vGene.html">vGene</a></code> 
+
+          <code><a href="vGene.html">vGene</a></code>
+
         </dt>
         <dd>vGene result for a recount dataset, SRP045638</dd>
       </dl><dl><dt>
-          
-          <code><a href="yy1_ex.html">yy1_ex</a></code> 
+
+          <code><a href="yy1_ex.html">yy1_ex</a></code>
+
         </dt>
         <dd>RNASeq2GeneNorm measures for YY1 from TCGA ACC samples</dd>
       </dl></div>
@@ -182,18 +192,18 @@ <h2 id="all-functions">All functions<a class="anchor" aria-label="anchor" href="
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
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 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
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     </footer></div>
 
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diff --git a/docs/reference/is_flush.html b/docs/reference/is_flush.html
index 2f09e26..5ae469c 100644
--- a/docs/reference/is_flush.html
+++ b/docs/reference/is_flush.html
@@ -1,59 +1,47 @@
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-      <img src="" class="logo" alt=""><h1>test for flush</h1>
+
+      <h1>test for flush</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/poker.R" class="external-link"><code>R/poker.R</code></a></small>
       <div class="d-none name"><code>is_flush.Rd</code></div>
     </div>
@@ -69,7 +57,9 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>x</dt>
+
+
+<dl><dt id="arg-x">x<a class="anchor" aria-label="anchor" href="#arg-x"></a></dt>
 <dd><p>a vector of cards</p></dd>
 
 </dl></div>
@@ -84,23 +74,23 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-out co"><span class="r-pr">#&gt;</span> [1] TRUE</span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
     <footer><div class="pkgdown-footer-left">
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+  <p>Developed by Vince Carey.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
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@@ -1,59 +1,47 @@
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 </nav><div class="container template-reference-topic">
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-      <img src="" class="logo" alt=""><h1>model matrix for SRP045638, see vGene</h1>
+
+      <h1>model matrix for SRP045638, see vGene</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/data.R" class="external-link"><code>R/data.R</code></a></small>
       <div class="d-none name"><code>mod.Rd</code></div>
     </div>
@@ -72,23 +60,23 @@ <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a><
     <p>data.frame</p>
     </div>
 
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
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diff --git a/docs/reference/nonlindat-1.png b/docs/reference/nonlindat-1.png
index b6b9503..c6e1019 100644
Binary files a/docs/reference/nonlindat-1.png and b/docs/reference/nonlindat-1.png differ
diff --git a/docs/reference/nonlindat.html b/docs/reference/nonlindat.html
index 6f193cd..f94ec76 100644
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@@ -1,59 +1,47 @@
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-      <img src="" class="logo" alt=""><h1>a data frame with y and x in a sigmoidal relationship (with error and a covariate z)</h1>
+
+      <h1>a data frame with y and x in a sigmoidal relationship (with error and a covariate z)</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/data.R" class="external-link"><code>R/data.R</code></a></small>
       <div class="d-none name"><code>nonlindat.Rd</code></div>
     </div>
@@ -79,23 +67,23 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-plt img"><img src="nonlindat-1.png" alt="" width="700" height="433"></span>
 </code></pre></div>
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-      <img src="" class="logo" alt=""><h1>test for one pair</h1>
+
+      <h1>test for one pair</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/poker.R" class="external-link"><code>R/poker.R</code></a></small>
       <div class="d-none name"><code>one_pair.Rd</code></div>
     </div>
@@ -69,15 +57,15 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>x</dt>
+
+
+<dl><dt id="arg-x">x<a class="anchor" aria-label="anchor" href="#arg-x"></a></dt>
 <dd><p>a vector of cards</p></dd>
 
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    
-
-<p>logical(1)</p>
+    <p>logical(1)</p>
     </div>
 
     <div class="section level2">
@@ -95,23 +83,23 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-out co"><span class="r-pr">#&gt;</span> [1] FALSE</span>
 </code></pre></div>
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-      <img src="" class="logo" alt=""><h1>use a snapshot of CuratedQueryAtlasR through duckdb</h1>
+
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       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/queryCHCA.R" class="external-link"><code>R/queryCHCA.R</code></a></small>
       <div class="d-none name"><code>queryCHCA.Rd</code></div>
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@@ -69,47 +57,47 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
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 <dd><p>connection to duckdb::duckdb(...)</p></dd>
 
 
-<dt>inst</dt>
+<dt id="arg-inst">inst<a class="anchor" aria-label="anchor" href="#arg-inst"></a></dt>
 <dd><p>logical(1) if TRUE install httpfs in duckdb</p></dd>
 
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    
-
-<p>dplyr::tbl for metadata</p>
+    <p>dplyr::tbl for metadata</p>
     </div>
 
     <div class="section level2">
     <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-examples"></a></h2>
     <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/interactive.html" class="external-link">interactive</a></span><span class="op">(</span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span></span>
-<span class="r-in"><span><span class="va">con</span> <span class="op">=</span> <span class="fu">DBI</span><span class="fu">::</span><span class="fu"><a href="https://dbi.r-dbi.org/reference/dbConnect.html" class="external-link">dbConnect</a></span><span class="op">(</span><span class="fu">duckdb</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/duckdb/man/duckdb.html" class="external-link">duckdb</a></span><span class="op">(</span><span class="op">)</span><span class="op">)</span></span></span>
+<span class="r-in"><span><span class="va">con</span> <span class="op">=</span> <span class="fu">DBI</span><span class="fu">::</span><span class="fu"><a href="https://dbi.r-dbi.org/reference/dbConnect.html" class="external-link">dbConnect</a></span><span class="op">(</span><span class="fu">duckdb</span><span class="fu">::</span><span class="fu"><a href="https://r.duckdb.org/reference/duckdb.html" class="external-link">duckdb</a></span><span class="op">(</span><span class="op">)</span><span class="op">)</span></span></span>
 <span class="r-in"><span><span class="fu">queryCHCA</span><span class="op">(</span><span class="va">con</span><span class="op">)</span> <span class="op">|&gt;</span> <span class="fu">select</span><span class="op">(</span><span class="va">sample_</span><span class="op">)</span> <span class="op">|&gt;</span> <span class="fu"><a href="https://rdrr.io/r/utils/head.html" class="external-link">head</a></span><span class="op">(</span><span class="op">)</span></span></span>
 <span class="r-in"><span><span class="fu">DBI</span><span class="fu">::</span><span class="fu"><a href="https://dbi.r-dbi.org/reference/dbDisconnect.html" class="external-link">dbDisconnect</a></span><span class="op">(</span><span class="va">con</span><span class="op">)</span></span></span>
 <span class="r-in"><span><span class="op">}</span></span></span>
 </code></pre></div>
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-      <img src="" class="logo" alt=""><h1>get suits of a collection of cards</h1>
+
+      <h1>get suits of a collection of cards</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/build_deck.R" class="external-link"><code>R/build_deck.R</code></a></small>
       <div class="d-none name"><code>suits.Rd</code></div>
     </div>
@@ -69,7 +57,9 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>x</dt>
+
+
+<dl><dt id="arg-x">x<a class="anchor" aria-label="anchor" href="#arg-x"></a></dt>
 <dd><p>a card from a deck made by `build_deck`</p></dd>
 
 </dl></div>
@@ -83,23 +73,23 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-out co"><span class="r-pr">#&gt;</span> [1] "♡" "♡"</span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
     <footer><div class="pkgdown-footer-left">
-  <p></p><p>Developed by Vince Carey.</p>
+  <p>Developed by Vince Carey.</p>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p></p><p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.1.</p>
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diff --git a/docs/reference/two_pairs.html b/docs/reference/two_pairs.html
index 8bd957f..b53cc6d 100644
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@@ -1,59 +1,47 @@
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-      <img src="" class="logo" alt=""><h1>test for two pairs</h1>
+
+      <h1>test for two pairs</h1>
       <small class="dont-index">Source: <a href="https://github.com/vjcitn/CSHstats/blob/HEAD/R/poker.R" class="external-link"><code>R/poker.R</code></a></small>
       <div class="d-none name"><code>two_pairs.Rd</code></div>
     </div>
@@ -69,7 +57,9 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>x</dt>
+
+
+<dl><dt id="arg-x">x<a class="anchor" aria-label="anchor" href="#arg-x"></a></dt>
 <dd><p>a vector of cards</p></dd>
 
 </dl></div>
@@ -84,23 +74,23 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-out co"><span class="r-pr">#&gt;</span> [1] FALSE</span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
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+  <p>Developed by Vince Carey.</p>
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diff --git a/docs/reference/vGene.html b/docs/reference/vGene.html
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+++ b/docs/reference/vGene.html
@@ -1,59 +1,47 @@
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@@ -76,23 +64,23 @@ <h2 id="note">Note<a class="anchor" aria-label="anchor" href="#note"></a></h2>
     <p>see https://lcolladotor.github.io/cshl_rstats_genome_scale_2023/differential-gene-expression-analysis-with-limma.html#differential-expression</p>
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-      <img src="" class="logo" alt=""><h1>RNASeq2GeneNorm measures for YY1 from TCGA ACC samples</h1>
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@@ -72,23 +60,23 @@ <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a><
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diff --git a/docs/search.json b/docs/search.json
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-[{"path":"/articles/S1_probability.html","id":"learning-objectives","dir":"Articles","previous_headings":"","what":"Learning objectives","title":"S1_probability: Definitions and exercises","text":"understand use sample() understand use set.seed() control behavior random number generation distinguish sample size experiment replication size simulation Explain relationship precision probability estimate sample size associated experiment binomially distributed outcomes outcomes governed Poisson Negative Binomial models general Understand simulate data null (e.g., fair deck) alternative (e.g., biased deck) conditions Understand difference finite, countably infinite, uncountably infinite sample spaces Define use probability density functions cumulative distribution functions continuous outcomes joint probability distribution two random quantities contours bivariate density: empirical model-based covariance correlation","code":""},{"path":"/articles/S1_probability.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"S1_probability: Definitions and exercises","text":"concept probability “long run relative frequency”. ’ll work several models random events make concrete.","code":""},{"path":[]},{"path":[]},{"path":"/articles/S1_probability.html","id":"random-permutations-with-sample","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards","what":"Random permutations with sample()","title":"S1_probability: Definitions and exercises","text":"’ll take granted sample(x, size=length(x), replace=FALSE) R achieves goal “shuffling” elements x. Thus assume , x vector R, aspect ordering elements s1 can used predict anything ordering elements s2. words, sample(x, size, replace=FALSE) taken primitive operation permutes elements x “random” way.","code":"s1 = sample(x, size=length(x), replace=FALSE) s2 = sample(x, size=length(x), replace=FALSE) set.seed(5432) # initialize, for reproducibility, the random number generator sample(1:5, replace=FALSE) # permute (1,2,3,4,5) ## [1] 4 2 1 3 5 sample(1:5, replace=FALSE) # a new, unpredictable, permutation ## [1] 3 4 1 2 5"},{"path":"/articles/S1_probability.html","id":"exercises","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards > Random permutations with sample()","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"1: second permutation produced termed “unpredictable”? 2: Predict outcome sample(1:5, replace=FALSE), run just one shown .","code":""},{"path":"/articles/S1_probability.html","id":"card-deck-definitions-and-operations","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards","what":"Card deck definitions and operations","title":"S1_probability: Definitions and exercises","text":"card deck vector 52 elements. Unicode characters encode “suits”. already installed CSHstats (long time ago) use get access software needed computations document. fair deck one card combination “face” “suit”.","code":"BiocManager::install(\"vjcitn/CSHstats\")  # install.packages(\"BiocManager\") if necessary library(CSHstats) d = build_deck() d ##  [1] \"2 ♡\"  \"3 ♡\"  \"4 ♡\"  \"5 ♡\"  \"6 ♡\"  \"7 ♡\"  \"8 ♡\"  \"9 ♡\"  \"10 ♡\" \"J ♡\"  ## [11] \"Q ♡\"  \"K ♡\"  \"A ♡\"  \"2 ♢\"  \"3 ♢\"  \"4 ♢\"  \"5 ♢\"  \"6 ♢\"  \"7 ♢\"  \"8 ♢\"  ## [21] \"9 ♢\"  \"10 ♢\" \"J ♢\"  \"Q ♢\"  \"K ♢\"  \"A ♢\"  \"2 ♣\"  \"3 ♣\"  \"4 ♣\"  \"5 ♣\"  ## [31] \"6 ♣\"  \"7 ♣\"  \"8 ♣\"  \"9 ♣\"  \"10 ♣\" \"J ♣\"  \"Q ♣\"  \"K ♣\"  \"A ♣\"  \"2 ♤\"  ## [41] \"3 ♤\"  \"4 ♤\"  \"5 ♤\"  \"6 ♤\"  \"7 ♤\"  \"8 ♤\"  \"9 ♤\"  \"10 ♤\" \"J ♤\"  \"Q ♤\"  ## [51] \"K ♤\"  \"A ♤\" unique(suits(d)) ## [1] \"♡\" \"♢\" \"♣\" \"♤\" unique(faces(d)) ##  [1] \"2\"  \"3\"  \"4\"  \"5\"  \"6\"  \"7\"  \"8\"  \"9\"  \"10\" \"J\"  \"Q\"  \"K\"  \"A\" table(suits(d), faces(d)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1"},{"path":"/articles/S1_probability.html","id":"exercises-1","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards > Card deck definitions and operations","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"3: Write code produces new deck fair except two copies ten hearts. Verify new deck property.","code":""},{"path":"/articles/S1_probability.html","id":"shuffling-the-deck","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards","what":"Shuffling the deck","title":"S1_probability: Definitions and exercises","text":"reproducible shuffling event can programmed follows:","code":"set.seed(1234)  # any numeric seed will do but you need to record it shuffle_deck = function(d) sample(d, size=length(d), replace=FALSE) head(d)         # top 6 cards ## [1] \"2 ♡\" \"3 ♡\" \"4 ♡\" \"5 ♡\" \"6 ♡\" \"7 ♡\" head(shuffle_deck(d)) ## [1] \"3 ♣\"  \"4 ♢\"  \"10 ♢\" \"Q ♣\"  \"6 ♤\"  \"9 ♤\""},{"path":"/articles/S1_probability.html","id":"the-top-card-after-a-shuffle","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards","what":"The top card after a shuffle","title":"S1_probability: Definitions and exercises","text":"","code":"set.seed(4141) top_draw = function(d) shuffle_deck(d)[1] top_draw(d) ## [1] \"A ♤\" top_draw(d) ## [1] \"5 ♤\""},{"path":"/articles/S1_probability.html","id":"exercises-2","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards > The top card after a shuffle","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"4: top card next shuffle? 5: Write code get third card. 6: probability top draw shuffled fair deck heart?","code":""},{"path":[]},{"path":"/articles/S1_probability.html","id":"a-simulation-process-repeated-shuffles-and-draws","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Estimating the probability of an event","what":"A simulation process: repeated shuffles and draws","title":"S1_probability: Definitions and exercises","text":"’s simple way estimating probability top draw shuffled fair deck heart, construed long run frequency. ’ll simulate 100 shuffles save results testing suit top card. concise approach R :","code":"heart_sign = function() \"\\U2661\"  # unicode U2661, prepend backslash heart_sign() ## [1] \"♡\" res = rep(NA, 100) for (i in 1:100) {  res[i] = (suits(top_draw(d)) == heart_sign()) # TRUE if top card is a heart } head(res) ## [1] FALSE FALSE  TRUE  TRUE  TRUE FALSE ### relative frequency of the event \"suit of top card is 'heart'\" sum(res)/length(res) ## [1] 0.36 mean(replicate( 100, suits(top_draw(d)) == heart_sign()) ) ## [1] 0.22"},{"path":"/articles/S1_probability.html","id":"exercises-3","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Estimating the probability of an event > A simulation process: repeated shuffles and draws","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"7: interpret difference two probability estimates given ?","code":""},{"path":"/articles/S1_probability.html","id":"replicating-the-estimation-process","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Estimating the probability of an event","what":"Replicating the estimation process","title":"S1_probability: Definitions and exercises","text":"Let’s intensify investigation aim understanding uncertainty estimation. ’ll define variable gives size “experiment”: shuffling 100 times ’ll refer sample size, SSIZE study estimation procedure replicating experiment N_REPLICATION times.","code":"SSIZE = 100 N_REPLICATION = 500 set.seed(10101) # initialize, for reproducibility, the random number generator doubsim = replicate(N_REPLICATION,      mean(replicate( SSIZE, suits(top_draw(d)) == heart_sign()) )     ) hist(doubsim, xlim=c(0,1))"},{"path":"/articles/S1_probability.html","id":"exercises-4","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Estimating the probability of an event > Replicating the estimation process","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"8: can make estimate probability event “suit top card ‘heart’” precise? Answer: increase SSIZE.  increased “sample size”, reduced variation experiment--experiment estimates probability heart suit top card.","code":"SSIZE = 500 set.seed(101012) doubsim2 = replicate(N_REPLICATION,      mean(replicate( SSIZE, suits(top_draw(d)) == heart_sign()) )     ) hist(doubsim2, xlim=c(0,1))"},{"path":"/articles/S1_probability.html","id":"formal-probability-models","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event","what":"Formal probability models","title":"S1_probability: Definitions and exercises","text":"Intuitively, probability drawing heart well-shuffled fair deck 1/4. repeat shuffling drawing one hundred times, expect around 25 draws reveal heart. Formal probability models enable us reason systematically mean around description expectation. models can also create accurate predictions likely outcomes complex events. useful define sample space probability model, set possible outcomes random process modeled. top-card-drawn example, sample space set suits, disregard face value. fair deck, point sample space probability \\(1/4\\). Events interest “top card heart” “top card heart”. probabilities events derivable probabilities constituent outcomes.","code":""},{"path":"/articles/S1_probability.html","id":"using-the-binomial-probability-model","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Formal probability models","what":"Using the binomial probability model","title":"S1_probability: Definitions and exercises","text":"series independent dichotomous events (true false, zero one, heart non-heart) can modeled using probability mass function binomial distribution. two parameters, \\(p\\) \\(n\\), \\(p\\) (unobservable) probability event (say “suit top card ‘heart’”) \\(n\\) number independent trials random dichotomy observed. \\(n\\) “trials”, event probability \\(p\\), probability seeing event \\(x\\) times \\[ Pr(X = x; n, p) = {\\binom{n}{x}} p^x(1-p)^{n-x} \\] written \\(X\\) denote random quantity \\(x\\) denote realization. single draw, \\(X\\) count hearts seen draw, \\[ Pr(X=0; 1, 1/4) = 1-1/4 = 3/4 \\] \\[ Pr(X=1; 1, 1/4) = 1/4 \\]","code":""},{"path":"/articles/S1_probability.html","id":"exercises-5","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Formal probability models > Using the binomial probability model","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"9: Modify production doubsim2 \\(x\\)-axis histogram units “number times top card heart”.","code":"hist(doubsim3, xlim=c(.15*500,.35*500), xlab=\"count of draws with heart as suit of top card\")"},{"path":"/articles/S1_probability.html","id":"visualizing-the-model-and-the-data","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Formal probability models","what":"Visualizing the model and the data","title":"S1_probability: Definitions and exercises","text":"formula given tells us frequently observe given count. R function dbinom can compute probability, multiply number realizations get height histogram.  Notice histogram, virtue binning counts, seem reflect shape theoretical frequency function given dots. can remedied increasing number replicates used. considerable research regarding design histogram displays. See ?nclass.Sturges references. One unpleasant feature display doubsim2 seems imply asymmetric distribution. Another way “cuts ” extremes.","code":"hist(doubsim3, xlim=c(.15*500,.35*500),     xlab=\"count of draws with heart as suit of top card\", ylim=c(0,115)) points(80:160, 2500*dbinom(80:160, 500, 13/52), pch=19, cex=.5) legend(78, 110, pch=19, legend=\"scaled dbinom(x, 500, .25)\", bty=\"n\", cex=.85)"},{"path":"/articles/S1_probability.html","id":"exercises-6","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Formal probability models > Visualizing the model and the data","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"10: Write couple sentences carefully distinguishing displays doubsim2 doubsim3 . Explain choice heuristic name “doubsim”.","code":""},{"path":"/articles/S1_probability.html","id":"a-biased-deck","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event","what":"A biased deck","title":"S1_probability: Definitions and exercises","text":"Recall layout fair deck: make copy one card remove one:","code":"table(suits(d), faces(d)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 bd = d bd[18] = bd[3] table(suits(bd), faces(bd)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 2 1 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 0 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1"},{"path":"/articles/S1_probability.html","id":"exercises-7","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > A biased deck","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"11: probability top card drawn shuffle bd heart? 12: probability top card drawn shuffle bd club?","code":""},{"path":"/articles/S1_probability.html","id":"probability-models-for-categorical-outcomes","dir":"Articles","previous_headings":"","what":"Probability models for categorical outcomes","title":"S1_probability: Definitions and exercises","text":"Thus far focused dichotomy: top draw heart . can consider possible suits 4-valued response.","code":""},{"path":"/articles/S1_probability.html","id":"a-contingency-table","dir":"Articles","previous_headings":"Probability models for categorical outcomes","what":"A contingency table","title":"S1_probability: Definitions and exercises","text":"Let’s simulate process drawing top card shuffling, tabulate suits observed.","code":"set.seed(4321) table( tops <- replicate(500, suits(top_draw(bd))) ) ##  ##   ♡   ♢   ♣   ♤  ## 148 106 126 120"},{"path":"/articles/S1_probability.html","id":"exercises-8","dir":"Articles","previous_headings":"Probability models for categorical outcomes > A contingency table","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"13: expect counts suits table deck fair?","code":""},{"path":"/articles/S1_probability.html","id":"multinomial-model-and-simulation","dir":"Articles","previous_headings":"Probability models for categorical outcomes","what":"Multinomial model and simulation","title":"S1_probability: Definitions and exercises","text":"adopted binomial model number top draws suit “heart” fixed number shuffles: \\[ Pr(X = x; n, p) = {\\binom{n}{x}} p^x(1-p)^{n-x} \\] fair deck, \\(p= 1/4\\). generalization vector responses multinomial model. can use (ordered) vector counts top draws yielding different suits. problem parameters \\(N\\) (number trials), \\(k\\) (number categories), \\(p_1, \\ldots, p_k\\), category-specific probabilities. realizations denoted \\(x_1, \\ldots, x_k\\) \\(\\sum_i x_i = N\\). Now probability model defined terms random vectors vectors probabilities: \\[ Pr(X_1 = x_1, \\ldots, X_k = x_k) = \\frac{n!}{x_1! \\cdots x_k!} p_1^{x_1} \\cdots p_k^{x_k} \\] provides elegant way producing frequency distributions suit top draw. introduce pseudorandom number generation multinomial model, using rmultinom. Notice use deck d producing matrix counts. Previously applied sample() 52-vector cards. Now use model develop data interest.","code":"NREP = 10000 SSIZE = 500 mnmat = rmultinom(NREP, SSIZE, rep(.25,4)) rownames(mnmat) = c(\"\\U2661\", \"\\U2662\", \"\\U2663\", \"\\U2664\") mnmat[,1]  # one draw ##   ♡   ♢   ♣   ♤  ## 131 125 110 134 apply(mnmat,1,mean) ##        ♡        ♢        ♣        ♤  ## 124.9621 124.9080 125.0362 125.0937"},{"path":"/articles/S1_probability.html","id":"exercise","dir":"Articles","previous_headings":"Probability models for categorical outcomes > Multinomial model and simulation","what":"Exercise","title":"S1_probability: Definitions and exercises","text":"14: Modify call rmultinom obtain distributions top card suits biased deck bd. Hint: Change part call involving rep().","code":""},{"path":[]},{"path":"/articles/S1_probability.html","id":"modeling-collections-of-counts","dir":"Articles","previous_headings":"Probability models for categorical outcomes > The Poisson distribution","what":"Modeling collections of counts","title":"S1_probability: Definitions and exercises","text":"Outcomes taking form integer counts arise many appications. example, quarry floor divided squares one meter side. 30 squares searched fossil number specimens per square recorded. square 5 specimens. (Example Probability Models Applications, . Olkin, L. Gleser, C. Derman, ch 6.3.) table includes nspec, number specimens square, freq, number squares corresponding number specimens, pred, predicted number specimens based Poisson model mean parameter 0.73 specimens per square. derive quantities pred, used dpois counts per square, mean parameter set 0.73. derive , use obtain average number fossils per square. Poisson model mean \\(\\lambda\\) \\[ Pr(X = k; \\lambda) = \\frac{e^{-\\lambda}\\lambda^k}{k!} \\]","code":"foss = data.frame(nspec=0:4, freq=c(16,9,3,1,1), pred=round(30*dpois(0:4, 0.73), 2)) foss ##   nspec freq  pred ## 1     0   16 14.46 ## 2     1    9 10.55 ## 3     2    3  3.85 ## 4     3    1  0.94 ## 5     4    1  0.17 sum(foss$nspec * foss$freq)/30 ## [1] 0.7333333"},{"path":"/articles/S1_probability.html","id":"exercise-1","dir":"Articles","previous_headings":"Probability models for categorical outcomes > The Poisson distribution","what":"Exercise","title":"S1_probability: Definitions and exercises","text":"15: Use formula explain prediction 14.46 squares zero fossils.","code":""},{"path":"/articles/S1_probability.html","id":"a-countably-infinite-sample-space","dir":"Articles","previous_headings":"Probability models for categorical outcomes > The Poisson distribution","what":"A countably infinite sample space","title":"S1_probability: Definitions and exercises","text":"binomial multinomial models discussed finite discrete sample spaces. sample space Poisson model set non-negative integers. mass function arises fact \\(e^\\lambda = \\sum \\lambda^k/k!\\), sum taken non-negative integers.","code":""},{"path":"/articles/S1_probability.html","id":"the-negative-binomial-model","dir":"Articles","previous_headings":"Probability models for categorical outcomes","what":"The negative binomial model","title":"S1_probability: Definitions and exercises","text":"mass function \\[ p(x; \\theta, \\mu) = \\frac{\\Gamma(\\theta + x)}{\\Gamma(\\theta)y!}     \\frac{\\mu^y \\theta^\\theta}{(\\mu + \\theta)^{\\theta + y}} \\] useful later material.","code":""},{"path":"/articles/S1_probability.html","id":"mean-variance","dir":"Articles","previous_headings":"Probability models for categorical outcomes","what":"Mean, variance","title":"S1_probability: Definitions and exercises","text":"sample mean vector \\(x = (x_1, \\ldots, x_n)\\) defined \\(\\bar{x} = n^{-1}\\sum_i x_i\\). (unbiased estimator ) sample variance \\((n-1)^{-1}\\sum_i (x_i - \\bar{x})^2\\). sometimes refer mean variance context probability models rather samples. mean continuous distribution defined discrete distribution probability mass function \\(p\\) mean \\[ E(x) = \\sum x p(x), \\] sum taken sample space associated model. Writing \\(\\mu\\) mean value distribution study, variance discrete distribution \\[ V(x) = \\sum (x-\\mu)^2 p(x) dx. \\]","code":""},{"path":"/articles/S1_probability.html","id":"models-for-continuous-outcomes","dir":"Articles","previous_headings":"","what":"Models for continuous outcomes","title":"S1_probability: Definitions and exercises","text":"models ’ve considered thus far discrete responses – sample space either finite countably infinite. continuous responses, sample space uncountably infinite. sample space may interval real line, whole real line. discuss define probabilities subsets sample space.","code":""},{"path":"/articles/S1_probability.html","id":"univariate-response","dir":"Articles","previous_headings":"Models for continuous outcomes","what":"Univariate response","title":"S1_probability: Definitions and exercises","text":"concreteness, use RNA-seq data derived Cancer Genome Atlas. ’ll focus 79 values normalized RSEM-based estimates expression YY1 adrenocortical carcinoma. refer vector “real valued” outcomes.","code":"data(yy1_ex) head(yy1_ex) ## TCGA-OR-A5J1-01A-11R-A29S-07 TCGA-OR-A5J2-01A-11R-A29S-07  ##                    1455.8117                    1688.6318  ## TCGA-OR-A5J3-01A-11R-A29S-07 TCGA-OR-A5J5-01A-11R-A29S-07  ##                    1821.3598                    1877.6143  ## TCGA-OR-A5J6-01A-31R-A29S-07 TCGA-OR-A5J7-01A-11R-A29S-07  ##                     634.3023                    1132.3706"},{"path":"/articles/S1_probability.html","id":"cumulative-distribution-function-quantiles","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response","what":"Cumulative distribution function; quantiles","title":"S1_probability: Definitions and exercises","text":"’ll use capital letters denote random variables. formal definition “random variable” given textbooks; use term informally refer quantities regard random. function \\(F(x) = \\mbox{Pr}(X < x)\\) called cumulative distribution function (CDF) random variable \\(X\\). YY1 measures, can produce visualization associated CDF:  quantiles distribution given inverse CDF. quantile function takes number \\(p\\) 0 1 returns number \\(F^{-1}(p)\\). graph shows 0.80 quantile distribution YY1 vector 1584.","code":"plot(ecdf(yy1_ex)) abline(h=.8, lty=2) arrows(1583, .8, 1583, 0, lty=2)"},{"path":"/articles/S1_probability.html","id":"exercise-2","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response","what":"Exercise","title":"S1_probability: Definitions and exercises","text":"16: Show proportion YY1 observations exceeding 1584 approximately 20%.","code":""},{"path":"/articles/S1_probability.html","id":"histogram-probability-density-function","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response","what":"Histogram, probability density function","title":"S1_probability: Definitions and exercises","text":"histogram tunable display relative frequencies values vector.  probability density function continuous random variable \\(X\\) satisfies \\[ \\int_a^b f(x) dx = \\mbox{Pr}(< X < b) \\] can estimate density function sample various ways. simple illustration:  interest use approxfun numerical integration density estimate given , estimate probability YY1 expression lies given interval. acceptable? changing bandwidth density estimator produce better results? potential overfitting problem?","code":"par(mfrow=c(2,1), mar=c(4,3,1,1)) hist(yy1_ex, xlim=c(400, 2600)) hist(yy1_ex, breaks=20, xlim=c(400, 2600)) plot(dd <- density(yy1_ex)) dfun = approxfun(dd$x, dd$y) integrate(dfun, 1000, 1500)  # density-based ## 0.4821651 with absolute error < 1e-05 mean(yy1_ex >=1000 & yy1_ex <= 1500) # empirical ## [1] 0.5316456"},{"path":"/articles/S1_probability.html","id":"some-widely-used-models-for-continuous-responses","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response","what":"Some widely used models for continuous responses","title":"S1_probability: Definitions and exercises","text":"’ll use simulation illustrate shapes various distributions. R makes simple family functions whose names begin r.","code":""},{"path":"/articles/S1_probability.html","id":"uniform-distribution-on-01","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response > Some widely used models for continuous responses","what":"Uniform distribution on [0,1]","title":"S1_probability: Definitions and exercises","text":"density function \\(f(x) = 1\\) \\(x \\[0,1]\\) 0 otherwise.","code":"hist(runif(10000, 0, 1), prob=TRUE)"},{"path":"/articles/S1_probability.html","id":"exercise-3","dir":"Articles","previous_headings":"","what":"S1_probability: Definitions and exercises","title":"S1_probability: Definitions and exercises","text":"17: Use code like obtain value density random variable uniform density interval [0, 2].","code":""},{"path":"/articles/S1_probability.html","id":"gaussian-model","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response > Some widely used models for continuous responses","what":"Gaussian model","title":"S1_probability: Definitions and exercises","text":"Gaussian distribution also called “normal”. shape position real line determined mean variance. Symbolically, model often written \\(N(\\mu, \\sigma^2)\\), density function \\(f(x) = 1/\\sqrt{2\\pi \\sigma^2} \\exp\\{(x-\\mu)^2/2 \\sigma^2\\}\\).","code":"hist(rnorm(10000, 0, 1), prob=TRUE) lines(seq(-4,4,len=100), dnorm(seq(-4,4,len=100)))"},{"path":"/articles/S1_probability.html","id":"exponential-and-gamma-models-for-survival-data","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response > Some widely used models for continuous responses","what":"Exponential and Gamma models for survival data","title":"S1_probability: Definitions and exercises","text":"exponential model (confused exponential family models) defined random variables positive values. example survival times. ’ll use dataset survival package illustrate.  density function exponential model \\(f(x) = \\lambda e ^ {-\\lambda x}\\). formulation, \\(\\lambda\\) referred rate parameter. mean distribution \\(1/\\lambda\\).","code":"library(survival) # use myeloma records from Mayo clinic, remove censored times md = myeloma$futime[myeloma$death==1 & myeloma$entry == 0] hist(md, breaks=20, prob=TRUE, ylim=c(0,.001)) mean(md) ## [1] 1044.768 ss = seq(0,8000,.1) lines(ss, dexp(ss, rate=1/mean(md)))"},{"path":"/articles/S1_probability.html","id":"exercise-4","dir":"Articles","previous_headings":"","what":"S1_probability: Definitions and exercises","title":"S1_probability: Definitions and exercises","text":"18: close median exponential model rate 1/1045 sample median myeloma survival times? relate interpretation plot ?","code":""},{"path":"/articles/S1_probability.html","id":"mean-and-variance-for-continuous-models","dir":"Articles","previous_headings":"Models for continuous outcomes","what":"Mean and variance for continuous models","title":"S1_probability: Definitions and exercises","text":"continuous distributions, mean value \\[ E(x) = \\int x f(x) dx. \\] Writing \\(\\mu\\) mean value distribution study, variance continuous distribution \\[ V(x) = \\int (x-\\mu)^2 f(x) dx. \\]","code":""},{"path":"/articles/S1_probability.html","id":"multivariate-response","dir":"Articles","previous_headings":"Models for continuous outcomes","what":"Multivariate response","title":"S1_probability: Definitions and exercises","text":"’ve seen use univariate probability models many facets. concept joint distribution multiple random quantities central reasoning interactions among components complicated processes. following example, obtained normalized expression measures EGR1 FOS adrenocortical carcinoma tumors studied TCGA. ’ll use built-bivariate density estimation show relationship expression two transcription factors ACC.","code":"data(fos_ex) data(egr1_ex) bivdf = data.frame(fos_ex, egr1_ex) library(ggplot2) ggplot(bivdf, aes(x=log(fos_ex), y=log(egr1_ex))) + geom_point() + geom_density_2d()"},{"path":"/articles/S1_probability.html","id":"joint-cumulative-distribution-function","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Joint cumulative distribution function","title":"S1_probability: Definitions and exercises","text":"’ll focus case continuous bivariate response denoted \\((X,Y)\\). joint cumulative distribution function (cdf) \\[ F(x,y) = Pr(X < x, Y < y) \\] , log FOS log EGR1, can evaluate \\(F(7,7)\\) follows: call empirical estimate \\(F(7,7)\\).","code":"mean(log(fos_ex)<7 & log(egr1_ex)<7) ## [1] 0.278481"},{"path":"/articles/S1_probability.html","id":"covariance-matrix-bivariate-case","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Covariance matrix, bivariate case","title":"S1_probability: Definitions and exercises","text":"covariance two random variables \\(Cov(X,Y) = EXY - (EX)(EY)\\); covariance matrix symmetric, variances diagonal, covariance diagonal.","code":"var(log(fos_ex)) # univariate ## [1] 1.194019 covmat = var(cbind(log(fos_ex), log(egr1_ex))) # matrix covmat ##           [,1]      [,2] ## [1,] 1.1940188 0.9746936 ## [2,] 0.9746936 1.4137188"},{"path":"/articles/S1_probability.html","id":"using-the-bivariate-normal-model","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Using the bivariate normal model","title":"S1_probability: Definitions and exercises","text":"Given estimates bivariate mean covariance, can use multivariate normal cumulative density function produce contours distribution elliptical shapes, opposed wiggly contours saw .  estimate \\(F(7,7)\\) using model ’ll call model-based estimate \\(F(7,7)\\).","code":"bmean = c(mean(log(fos_ex)), mean(log(egr1_ex))) library(mvtnorm) xgrid = seq(3,10,.05) ygrid = seq(3,10,.05) ngrid = length(xgrid) nd = matrix(NA, ngrid, ngrid) for (i in 1:ngrid) {  # inefficient!  for (j in 1:ngrid) {   nd[i,j] = dmvnorm(c(xgrid[i],ygrid[j]), bmean, covmat)   }  } contour(xgrid, ygrid, nd, ylab=\"log EGR1\", xlab=\"log FOS\") points(log(fos_ex), log(egr1_ex), col=\"gray\", pch=19) pmvnorm(upper=c(7,7), mean=bmean, sigma=covmat) ## [1] 0.3368775 ## attr(,\"error\") ## [1] 1e-15 ## attr(,\"msg\") ## [1] \"Normal Completion\""},{"path":"/articles/S1_probability.html","id":"exercise-5","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response > Using the bivariate normal model","what":"Exercise","title":"S1_probability: Definitions and exercises","text":"19: Obtain empirical model-based estimates \\(F(6,5)\\) (log FOS, log EGR1).","code":""},{"path":"/articles/S1_probability.html","id":"probabilistic-independence-and-dependence","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Probabilistic independence and dependence","title":"S1_probability: Definitions and exercises","text":"“tilted contour ellipses” shown just indicate knowledge value log FOS tells us variation values log EGR1. log FOS 6, value log EGR1 much likely around 6 around 9. use concept conditional distribution address concept, denote conditional distribution function \\(F(x|y)\\), vertical bar denoting conditioning. Specifically, \\(F(x|Y=y)\\) = Pr(\\(X<x\\)) given \\(Y = y\\). Probabilistic independence two random quantities can formulated condition \\(F(x|y) = F(x)\\): knowledge value \\(Y\\) provides information distribution \\(X\\).","code":""},{"path":"/articles/S1_probability.html","id":"measures-of-correlation","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Measures of correlation","title":"S1_probability: Definitions and exercises","text":"correlation coefficient two random quantities ratio covariance square root product variances. 20: Use elements covmat computed produce estimate correlation log FOS log EGR1, compare cor() R (log FOS, log EGR1).","code":""},{"path":"/articles/S1b_hyper.html","id":"the-null-situation","dir":"Articles","previous_headings":"","what":"The “null” situation","title":"S1a: A look at the hypergeometric distribution","text":"two variables independent. Let’s think x “exposure” indicator, y “outcome”. 2x2 table relating exposure outcome : Notice marginal frequencies (column row proportions 0 1) similar x y. arises construction, two variables simulated separately. Exercise: interpretation numbers 0.389 0.393 table? test independence x y produced R.. Fisher. Exercise: interpretation p-value?","code":"set.seed(234) x = rbinom(100,1,.3) y = rbinom(100,1,.4) library(gmodels) CrossTable(x,y) ##  ##   ##    Cell Contents ## |-------------------------| ## |                       N | ## | Chi-square contribution | ## |           N / Row Total | ## |           N / Col Total | ## |         N / Table Total | ## |-------------------------| ##  ##   ## Total Observations in Table:  100  ##  ##   ##              | y  ##            x |         0 |         1 | Row Total |  ## -------------|-----------|-----------|-----------| ##            0 |        44 |        28 |        72 |  ##              |     0.000 |     0.000 |           |  ##              |     0.611 |     0.389 |     0.720 |  ##              |     0.721 |     0.718 |           |  ##              |     0.440 |     0.280 |           |  ## -------------|-----------|-----------|-----------| ##            1 |        17 |        11 |        28 |  ##              |     0.000 |     0.001 |           |  ##              |     0.607 |     0.393 |     0.280 |  ##              |     0.279 |     0.282 |           |  ##              |     0.170 |     0.110 |           |  ## -------------|-----------|-----------|-----------| ## Column Total |        61 |        39 |       100 |  ##              |     0.610 |     0.390 |           |  ## -------------|-----------|-----------|-----------| ##  ## fisher.test(table(x,y)) ##  ##  Fisher's Exact Test for Count Data ##  ## data:  table(x, y) ## p-value = 1 ## alternative hypothesis: true odds ratio is not equal to 1 ## 95 percent confidence interval: ##  0.3716153 2.7041308 ## sample estimates: ## odds ratio  ##   1.016643"},{"path":"/articles/S1b_hyper.html","id":"how-to-produce-correlated-binomial-responses","dir":"Articles","previous_headings":"","what":"How to produce “correlated binomial” responses?","title":"S1a: A look at the hypergeometric distribution","text":"simple way producing dependent binary responses via logistic regression relationship. produce x, can random deterministic, let probability y=1 depend value x. R’s vectorized computations make simple. Now cross-tab Fisher’s test Exercise: interpretation numbers 0.56 0.812 table? interpretation Fisher’s test p-value? features simulation changed make p-value smaller? Note: odds ratio reported Fisher test recovered (discrepancy owing rounding):","code":"x = rbinom(100,1,.3) y = rbinom(100,1, plogis(.2+x)) # summary(glm(y~x, fam=binomial)) CrossTable(x,y) ##  ##   ##    Cell Contents ## |-------------------------| ## |                       N | ## | Chi-square contribution | ## |           N / Row Total | ## |           N / Col Total | ## |         N / Table Total | ## |-------------------------| ##  ##   ## Total Observations in Table:  100  ##  ##   ##              | y  ##            x |         0 |         1 | Row Total |  ## -------------|-----------|-----------|-----------| ##            0 |        37 |        47 |        84 |  ##              |     0.344 |     0.229 |           |  ##              |     0.440 |     0.560 |     0.840 |  ##              |     0.925 |     0.783 |           |  ##              |     0.370 |     0.470 |           |  ## -------------|-----------|-----------|-----------| ##            1 |         3 |        13 |        16 |  ##              |     1.806 |     1.204 |           |  ##              |     0.188 |     0.812 |     0.160 |  ##              |     0.075 |     0.217 |           |  ##              |     0.030 |     0.130 |           |  ## -------------|-----------|-----------|-----------| ## Column Total |        40 |        60 |       100 |  ##              |     0.400 |     0.600 |           |  ## -------------|-----------|-----------|-----------| ##  ## fisher.test(table(x,y)) ##  ##  Fisher's Exact Test for Count Data ##  ## data:  table(x, y) ## p-value = 0.09295 ## alternative hypothesis: true odds ratio is not equal to 1 ## 95 percent confidence interval: ##   0.8399315 19.8105854 ## sample estimates: ## odds ratio  ##   3.374506 (.812/(1-.812))/(.56/(1-.56)) ## [1] 3.393617"},{"path":"/articles/S1b_hyper.html","id":"connection-to-the-hypergeometric-distribution","dir":"Articles","previous_headings":"","what":"Connection to the hypergeometric distribution","title":"S1a: A look at the hypergeometric distribution","text":"’ll start simple problem. urn contains 10 balls, red, blue. pick three balls without replacement note color. table shows two balls red, one blue. hypergeometric distribution used model situation, draw \\(n\\) balls urn holding \\(N\\) balls yields \\(r\\) balls given condition. table, probability draw given \\(\\frac{{5 \\choose 2} \\cdot {5 \\choose 1}}{10 \\choose 3}\\). case, Fisher’s test indicates association color presence draw. can use 1-sided test: Use hypergeometric probability function produce p-value: Note proportions preserved frequencies multiplied 10, different two-sided p-value, similar odds ratio. Exercise: reformulation analysis larger 2x2 table : Show log cross product ratio elements ta2 given coefficient ‘red’ binomial model .","code":"color = rep(c(\"red\", \"blue\"), each=5) picked = c(1,1,0,0,0,1,0,0,0,0) ta = table(color,picked) ta ##       picked ## color  0 1 ##   blue 4 1 ##   red  3 2 fisher.test(ta) ##  ##  Fisher's Exact Test for Count Data ##  ## data:  ta ## p-value = 1 ## alternative hypothesis: true odds ratio is not equal to 1 ## 95 percent confidence interval: ##    0.0847468 195.6529809 ## sample estimates: ## odds ratio  ##   2.414224 fisher.test(ta, alt=\"less\") ##  ##  Fisher's Exact Test for Count Data ##  ## data:  ta ## p-value = 0.9167 ## alternative hypothesis: true odds ratio is less than 1 ## 95 percent confidence interval: ##   0.00000 95.99192 ## sample estimates: ## odds ratio  ##   2.414224 sum(dhyper(0:2,5,5,3)) ## [1] 0.9166667 ta2 = 10*ta fisher.test(ta2) ##  ##  Fisher's Exact Test for Count Data ##  ## data:  ta2 ## p-value = 0.04858 ## alternative hypothesis: true odds ratio is not equal to 1 ## 95 percent confidence interval: ##  1.005329 7.317139 ## sample estimates: ## odds ratio  ##   2.640147 g = glm(formula = ta2[, 2:1] ~ factor(rownames(ta2)), family = binomial) summary(g) ##  ## Call: ## glm(formula = ta2[, 2:1] ~ factor(rownames(ta2)), family = binomial) ##  ## Coefficients: ##                          Estimate Std. Error z value Pr(>|z|)     ## (Intercept)               -1.3863     0.3536  -3.921 8.82e-05 *** ## factor(rownames(ta2))red   0.9808     0.4564   2.149   0.0316 *   ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## (Dispersion parameter for binomial family taken to be 1) ##  ##     Null deviance: 4.8315e+00  on 1  degrees of freedom ## Residual deviance: 8.8818e-15  on 0  degrees of freedom ## AIC: 12.268 ##  ## Number of Fisher Scoring iterations: 3"},{"path":"/articles/S2_EDA.html","id":"eda-exploratory-data-analysis","dir":"Articles","previous_headings":"","what":"EDA: Exploratory data analysis","title":"S2_EDA: Exploratory data analysis and visualization","text":"field EDA changed, thanks advances computational visualization technology. Classical EDA addressed Assessing distributional shape Comparing batches numbers: Boxplots beyond Transformations; handling “outliers” recently, can consider exploratory data activities use interactive tables interactive graphics purpose-built graphical user interfaces explore concerns. principles include high volumes involved, sampling dimension reduction relevant every facet data accessible exploration summarization","code":""},{"path":"/articles/S2_EDA.html","id":"learning-objectives","dir":"Articles","previous_headings":"","what":"Learning objectives","title":"S2_EDA: Exploratory data analysis and visualization","text":"simple statistics may fail disclose structure visualization always conducted understand might use shiny explore tunable data visualization Box-Cox transformation family provides clues choosing transformation look qqnorm, qqplot allows general comparisons Shiny + TnT allow exploration data context linear genome annotation","code":""},{"path":"/articles/S2_EDA.html","id":"anscombes-quartet-statistics-that-miss-the-point","dir":"Articles","previous_headings":"","what":"Anscombe’s quartet: statistics that miss the point","title":"S2_EDA: Exploratory data analysis and visualization","text":"1973 Francis Anscombe constructed four bivariate datasets. four datasets interest pairs columns (x1, y1), (x2, y2), …. discussion probability provided definitions mean, variance, covariance, correlation. quick check means variables quartet. use apply function general arguments X array-like entity, MARGIN defines dimension along FUN computed additional arguments possibly provided .... MARGIN 1, FUN computed “row”, MARGIN 2, FUN computed “column”. also introduce helper function rounded_stat rounds result univariate statistic. code demonstrates x y variables identical means standard deviations. Nevertheless, variables plotted one another, :","code":"library(DT) data(anscombe) datatable(anscombe) apply(X, MARGIN, FUN, ..., simplify=TRUE) rounded_stat = function(x, stat=mean, ndig=2) round(stat(x), ndig) apply(anscombe, 2, rounded_stat, stat=mean) ##  x1  x2  x3  x4  y1  y2  y3  y4  ## 9.0 9.0 9.0 9.0 7.5 7.5 7.5 7.5 apply(anscombe, 2, rounded_stat, stat=sd) ##   x1   x2   x3   x4   y1   y2   y3   y4  ## 3.32 3.32 3.32 3.32 2.03 2.03 2.03 2.03"},{"path":"/articles/S2_EDA.html","id":"exercises","dir":"Articles","previous_headings":"Anscombe’s quartet: statistics that miss the point","what":"Exercises","title":"S2_EDA: Exploratory data analysis and visualization","text":"1. Show four correlation coefficients (x1, y1), …, (x4, y4) identical (rounding). 2. blog post addresses tidyverse approach handling data. Read blog post try get comfortable various steps towards producing using “tidy” representation.","code":"# use BiocManager::install(\"tidyverse\") if necessary library(tidyverse) tidy_anscombe <- anscombe %>%  pivot_longer(cols = everything(),               names_to = c(\".value\", \"set\"),               names_pattern = \"(.)(.)\") library(ggplot2) ggplot(tidy_anscombe,        aes(x = x,            y = y)) +   geom_point() +    facet_wrap(~set) +   geom_smooth(method = \"lm\", se = FALSE) ## `geom_smooth()` using formula = 'y ~ x'"},{"path":[]},{"path":"/articles/S2_EDA.html","id":"univariate","dir":"Articles","previous_headings":"Exploring distributional shape","what":"Univariate","title":"S2_EDA: Exploratory data analysis and visualization","text":"mode distribution “common value”. peak histogram correspond mode corresponding distribution discrete random variable. continuous random variables, mode given peak density function. basic question univariate dataset : multimodal distribution? Live Exercise: programming interactive exploration. Use R studio’s File control produce new “Shiny app”, give name “modality”. use “Run app” control. slider controls number bins used summarize values times geyser eruption. many modes might underlying distribution ?","code":""},{"path":"/articles/S2_EDA.html","id":"transformation","dir":"Articles","previous_headings":"Exploring distributional shape","what":"Transformation","title":"S2_EDA: Exploratory data analysis and visualization","text":"search transformation best symmetrizes skewed distribution, boxcox function MASS library can used. origins procedure reported Royal Statistical Society 1964. JRSS paper basic idea can construct series functional transformations random variable produce distribution (transformed scale) approximately normal. Box-Cox family transformations indexed single parameter, \\(\\lambda\\). transformation variable \\(y\\) \\(y^*(\\lambda) = \\lambda^{-1}(y^\\lambda-1)\\) (\\(\\lambda \\neq 0\\)) log \\(y\\) \\(\\lambda = 0\\) provides smooth traversal (fractional) power, logarithm, reciprocal power operations \\(y\\). \\(\\lambda\\) 1, transformation indicated.  boxcox function MASS library trace likelihood function maximized distribution \\(y^*(\\lambda)\\) close Gaussian possible.","code":"opar = par(no.readonly=TRUE) par(mfrow=c(2,2), mar=c(3,2,1,1)) data(fos_ex) hist(fos_ex, main=\"raw\") hist(sqrt(fos_ex), main=\"sqrt\") hist(fos_ex^2, main=\"square\") hist(log(fos_ex), main=\"log\") par(opar) library(MASS) boxcox(fos_ex~1) # must use formula"},{"path":"/articles/S2_EDA.html","id":"exercise","dir":"Articles","previous_headings":"Exploring distributional shape > Transformation","what":"Exercise","title":"S2_EDA: Exploratory data analysis and visualization","text":"3. transformation boxcox() recommend applied log(egr1_ex)? 4. transformation boxcox() recommend applied geyser data started ?","code":""},{"path":"/articles/S2_EDA.html","id":"is-it-gaussian","dir":"Articles","previous_headings":"Exploring distributional shape","what":"Is it Gaussian?","title":"S2_EDA: Exploratory data analysis and visualization","text":"concept Q-Q plot (quantile-quantile plot) used compare given data vector reference distribution (distribution data vector).  configuration points Q-Q plot form straight line, reference distribution probably appropriate.","code":"qqnorm(fos_ex, main=\"Compare FOS to Gaussian distribution\")"},{"path":"/articles/S2_EDA.html","id":"exercises-1","dir":"Articles","previous_headings":"Exploring distributional shape > Is it Gaussian?","what":"Exercises","title":"S2_EDA: Exploratory data analysis and visualization","text":"5. Use qqnorm log(fos_ex) comment. 6. zsc = function(x) (x - mean(x))/sd(x). special qqnorm(zsc(log(fos_ex)))?","code":""},{"path":"/articles/S2_EDA.html","id":"bivariate","dir":"Articles","previous_headings":"Exploring distributional shape","what":"Bivariate","title":"S2_EDA: Exploratory data analysis and visualization","text":"can use density estimation plane reason multimodality bivariate data. example(geom_density_2d):","code":"library(datasets) data(faithful) m <- ggplot(faithful, aes(x = eruptions, y = waiting)) +   geom_point() + xlim(0.5, 6) + ylim(40, 110) # contour lines m + geom_density_2d()"},{"path":"/articles/S2_EDA.html","id":"exercise-1","dir":"Articles","previous_headings":"Exploring distributional shape > Bivariate","what":"Exercise","title":"S2_EDA: Exploratory data analysis and visualization","text":"7. Comment meaning “local modes” “marginal” displays.","code":"opar = par(no.readonly=TRUE) par(mfrow=c(1,2), mar=c(3,2,1,1)) plot(density(faithful$erup, .08)) plot(density(faithful$wait, 1.4)) par(opar)"},{"path":"/articles/S2_EDA.html","id":"exercise-2","dir":"Articles","previous_headings":"Exploring distributional shape > Bivariate","what":"Exercise","title":"S2_EDA: Exploratory data analysis and visualization","text":"8. (advanced): Produce shiny app controller bandwidth density estimator viewing bivariate structure faithful data. ```","code":""},{"path":"/articles/S2_EDA.html","id":"visualizing-data-in-the-context-of-the-genome","dir":"Articles","previous_headings":"","what":"Visualizing data in the context of the genome","title":"S2_EDA: Exploratory data analysis and visualization","text":"use https://vjcitn.shinyapps.io/tnt4dn8 look GWAS eQTL data jointly.","code":""},{"path":"/articles/S2a_PCAelem.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"S2a: Elements of PCA","text":"vignette explores basic aspects PCA bivariate 5-dimensional data. concludes remarks “eigengenes”, can verified using computations shown simpler cases.","code":""},{"path":"/articles/S2a_PCAelem.html","id":"make-a-bivariate-dataset-with-positive-correlation-and-heterogeneous-variance","dir":"Articles","previous_headings":"","what":"Make a bivariate dataset with positive correlation and heterogeneous variance","title":"S2a: Elements of PCA","text":"First create covariance matrix greater variance second variable pair. generate 20000 x 2 matrix bivariate normal deviates. data original units easy visualize:  Now perform PCA. don’t reduce dimensions, can get handle components formed interpreted.  PC1 produced taking linear combinations rows sim1. ’ll illustrate linear combination concept. data vector first row may written \\((x_1, x_2)\\), linear combination form \\(ax_1 + bx_2\\) coefficients \\(\\) \\(b\\). coefficients derived rotation component PCA. can done wholesale using matrix multiplication %*%: Exercises. Recover value prc$x[1,2] using second column prc$rotation. Examine plots  rotation “undone”. Letting \\(V\\) denote ‘rotation’ component PCA, shows matrix product \\(VV^t = \\), \\(\\) diagonal matrix 1 diagonal. background underlying computations can gleaned Wikipedia entry singular value decomposition.","code":"library(MASS) set.seed(1234) options(digits=3) cm = matrix(c(1,1,1,4), nr=2) cm ##      [,1] [,2] ## [1,]    1    1 ## [2,]    1    4 sim1 = mvrnorm(20000, c(0,0), cm) cov(sim1) ##       [,1]  [,2] ## [1,] 1.002 0.995 ## [2,] 0.995 3.973 cor(sim1) ##       [,1]  [,2] ## [1,] 1.000 0.499 ## [2,] 0.499 1.000 plot(sim1,xlim=c(-10,10), ylim=c(-10,10)) prc = prcomp(sim1, center=FALSE) plot(prc$x, xlim=c(-10,10), ylim=c(-10,10)) prc$rotation ##        PC1    PC2 ## [1,] 0.291  0.957 ## [2,] 0.957 -0.291 c11 = prc$rotation[1,1] c21 = prc$rotation[2,1] sim1[1,1]*c11 + sim1[1,2]*c21 ##  PC1  ## -2.5 prc$x[1,1] ##  PC1  ## -2.5 (sim1 %*% prc$rotation)[1:5,] ##         PC1    PC2 ## [1,] -2.502  1.412 ## [2,]  0.576  0.797 ## [3,]  2.250  0.539 ## [4,] -4.866 -0.213 ## [5,]  0.891  1.017 prc$x[1:5,] ##         PC1    PC2 ## [1,] -2.502  1.412 ## [2,]  0.576  0.797 ## [3,]  2.250  0.539 ## [4,] -4.866 -0.213 ## [5,]  0.891  1.017 all.equal(prc$x, sim1%*% prc$rotation) ## [1] TRUE par(mfrow=c(2,2), mar=c(4,4,3,1)) plot(sim1, xlim=c(-10,10), ylim=c(-10,10), main=\"raw data\",   xlab=\"data column 1\", ylab=\"data col. 2\") plot(sim1 %*% prc$rotation, xlim=c(-10,10), ylim=c(-10,10),   main=\"data %*% prc$rotation\", xlab=\"PC1 via rotation\",    ylab=\"PC2 via rotation\") plot(prc$x, xlim=c(-10,10), ylim=c(-10,10), main=\"x from prcomp\",     ) plot(sim1 %*%   prc$rotation %*% t(prc$rotation), xlim=c(-10,10), ylim=c(-10,10),   main=\"data %*% rot %*% t(rot)\", xlab=\"data %*% VVt (col 1)\",   ylab = \"data %*% VVt (col 2)\")"},{"path":"/articles/S2a_PCAelem.html","id":"a-larger-covariance-matrix","dir":"Articles","previous_headings":"","what":"A larger covariance matrix","title":"S2a: Elements of PCA","text":"5-dimensional dataset. set covariance matrix columns 1 2 negative correlation, columns 3 4 positive correlation, column 2 greatest overall variance, columns 1 3 elevated variance. pairs plot shows data original units.  verify multivariate structure: Compute PCA  biplot shows projection PC1-PC2 shows different variables related, drive projection.  Exercise: Explain configuration arrows biplot.","code":"cm = diag(5) cm[3,4] = cm[4,3] = .8 cm[1,2] = cm[2,1] = -.6 A = diag(5) A[1,1] = 2 A[2,2] = 3 A[3,3] = 2 covm = A%*%cm%*%A myd = mvrnorm(2000, rep(0,5), covm) pairs(myd, xlim=c(-10,10), ylim=c(-10,10)) cor(myd) ##         [,1]     [,2]     [,3]     [,4]    [,5] ## [1,]  1.0000 -0.61123  0.00340 -0.01582  0.0489 ## [2,] -0.6112  1.00000  0.00182 -0.00636 -0.0348 ## [3,]  0.0034  0.00182  1.00000  0.79564 -0.0380 ## [4,] -0.0158 -0.00636  0.79564  1.00000 -0.0276 ## [5,]  0.0489 -0.03478 -0.03797 -0.02760  1.0000 cov(myd) ##         [,1]    [,2]    [,3]    [,4]    [,5] ## [1,]  4.1482 -3.8816  0.0138 -0.0316  0.0986 ## [2,] -3.8816  9.7217  0.0113 -0.0195 -0.1075 ## [3,]  0.0138  0.0113  3.9702  1.5539 -0.0750 ## [4,] -0.0316 -0.0195  1.5539  0.9607 -0.0268 ## [5,]  0.0986 -0.1075 -0.0750 -0.0268  0.9816 dim(myd) ## [1] 2000    5 pp = prcomp(myd) pairs(pp$x) par(lwd=2) biplot(pp, xlabs=rep(\".\", 2000), expand=.8)"},{"path":"/articles/S2a_PCAelem.html","id":"eigengenes-derived-from-pca","dir":"Articles","previous_headings":"","what":"“Eigengenes” derived from PCA","title":"S2a: Elements of PCA","text":"rows samples columns genes, x components prcomp’s output linear combinations genes. coefficients combination derived PCA rotation matrix, constructed order PCs components capturing variation come first construct PCs mutually orthogonal Note simple reconstructions required prcomp used center=FALSE.","code":""},{"path":"/articles/S3_distclust.html","id":"road-map","dir":"Articles","previous_headings":"","what":"Road map","title":"S3: Distances, clustering","text":"Distances high-dimensional spaces Criteria agglomerative clustering interactive heatmap comparing Euclidean correlation (1-cor) distances comparing agglomeration methods silhouette measure clustering adequacy","code":""},{"path":"/articles/S3_distclust.html","id":"cluster-analysis-concepts","dir":"Articles","previous_headings":"","what":"Cluster analysis concepts","title":"S3: Distances, clustering","text":"need identify groups similar observations arises many contexts – ultimately service clarifying sources variability, building power statistical comparisons. Hierarchical clustering N multivariate observations conducted starting N clusters proceeding M clusters M-1 (M=N, …, 2) clusters merging two members separated least pairwise distances.","code":""},{"path":[]},{"path":[]},{"path":"/articles/S3_distclust.html","id":"application-inferring-steps-in-tumor-metastasis-in-a-breast-cancer-patient","dir":"Articles","previous_headings":"","what":"Application: inferring steps in tumor metastasis in a breast cancer patient","title":"S3: Distances, clustering","text":"’ll examine data distributed 2021 Genome Biology paper Gabor Marth lab. Clinical sequence interventions. Event sequence.","code":""},{"path":"/articles/S3_distclust.html","id":"a-view-of-copy-number-aberrations-for-1mb-tiling","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient","what":"A view of copy number aberrations for 1Mb tiling","title":"S3: Distances, clustering","text":"28 tumors sampled sequenced rapid autopsy procedure. Copy number variation assessed using FACETS. tissues tumors taken Br (Breast), Bo (Bone), Bn (Brain), Ln (Lung), Lv (Liver), Pa (Pancreas), Ly (Lymph nodes), Kd (Kidney) plotly-based visualization (vertical) ordering tissues chosen exemplify certain similarities. example block blue chr10 seen three samples. indication deletion.","code":""},{"path":"/articles/S3_distclust.html","id":"a-cluster-analysis-proposed-in-support-of-the-evolutionary-map","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient","what":"A cluster analysis proposed in support of the evolutionary map","title":"S3: Distances, clustering","text":"code lightly modified script distributed https://github.com/xiaomengh/tumor-evo-rapid-autopsy.git.","code":"suppressPackageStartupMessages({  library(csamaDist)  library(bioDist)  library(cluster) }) data(cnv_log_R) data = cnv_log_R samples = c('Ln7','Ln9','Ln1','BrM','BrP',            'Ln11','Ly2','Ln3',            'Bo3','Ln10','Bo1','Ln8','Lv3','Ln5','Bo2','Bn2','Bn1','Bn3','Bn4','Ln2',            'Ly1','Ln6',            'Kd1','Ln4','Lv4','Lv2','Lv1','Pa1') rownames(data) = samples d = dist(data, method=\"euclidean\") fit = hclust(d, method=\"average\") # the following line changes the order of the samples to produce the Fig.S3B but doesn't change the phylogenetic relationship fit$order = c(1,4,2,5,3,13,10,20,16,11,12,15,9,17,19,14,18,21,22,7,6,8,25,27,26,28,23,24) plot(fit)"},{"path":[]},{"path":"/articles/S3_distclust.html","id":"comparing-euclidean-and-correlation-distances","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"Comparing Euclidean and Correlation distances","title":"S3: Distances, clustering","text":"given correlation distance value, can wide variation euclidean distance, vice versa. Open question: distance metric relevant biological interpretation CNV?","code":"cd = cor.dist(cnv_log_R) # from bioDist ed = dist(cnv_log_R) plot(as.numeric(ed), as.numeric(cd), xlab=\"All pairwise Euclidean distances\", ylab=\"All pairwise correlation distances\")"},{"path":"/articles/S3_distclust.html","id":"a-pair-with-discrepant-correlation-and-euclidean-distance-values-over-entire-genome","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"A pair with discrepant correlation and euclidean distance values (over entire genome)","title":"S3: Distances, clustering","text":"’ll look first 100Mb chr1.","code":"plot(cnv_log_R[\"Ly1\",1:100],pch=19, main=\"chr1, first 100Mb\", ylab=\"FACETS CNV log R\", xlab=\"chr1\") points(cnv_log_R[\"Ln1\",1:100], col=\"red\",pch=19) legend(60, -.5, pch=19, col=c(\"black\", \"red\"), legend=c(\"Ly1\", \"Ln1\")) #cor(cnv_log_R[\"Ly1\", 1:100], cnv_log_R[\"Ln1\", 1:100]) edist = function(x,y) sqrt(sum((x-y)^2)) edist(cnv_log_R[\"Ly1\", 1:100], cnv_log_R[\"Ln1\", 1:100]) ## [1] 1.685992 plot(jitter(cnv_log_R[\"Ly1\", 1:100]), cnv_log_R[\"Ln1\", 1:100], xlab=\"Ly1\", ylab=\"Ln1\") abline(0,1)"},{"path":"/articles/S3_distclust.html","id":"redo-clustering-with-alternative-distance-and-agglomeration-method","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"Redo clustering with alternative distance and agglomeration method","title":"S3: Distances, clustering","text":"","code":"fit2 = hclust(cd, method=\"ward.D2\") plot(fit2) abline(h=.3, lty=2)"},{"path":"/articles/S3_distclust.html","id":"silhouette-measure","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"Silhouette measure","title":"S3: Distances, clustering","text":"?silhouette cluster library:","code":"For each observation i, the _silhouette width_ s(i) is defined as follows:       Put a(i) = average dissimilarity between i and all other points of      the cluster to which i belongs (if i is the _only_ observation in      its cluster, s(i) := 0 without further calculations).  For all      _other_ clusters C, put d(i,C) = average dissimilarity of i to all      observations of C.  The smallest of these d(i,C) is b(i) := \\min_C      d(i,C), and can be seen as the dissimilarity between i and its      \"neighbor\" cluster, i.e., the nearest one to which it does _not_      belong.  Finally,                     s(i) := ( b(i) - a(i) ) / max( a(i), b(i) ).                     'silhouette.default()' is now based on C code donated by Romain      Francois (the R version being still available as      'cluster:::silhouette.default.R').       Observations with a large s(i) (almost 1) are very well clustered,      a small s(i) (around 0) means that the observation lies between      two clusters, and observations with a negative s(i) are probably      placed in the wrong cluster. ct1 = cutree(fit2, h=.3) c2 = cnv_log_R rownames(c2) = paste(rownames(c2), as.numeric(ct1)) sil = silhouette(ct1, cd) plot(sil)"},{"path":"/articles/S3_distclust.html","id":"exercises","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"Exercises","title":"S3: Distances, clustering","text":"1: install bioDist vjcitn/csamaDist. Use code: Comment qualitative differences clusterings. 2: produce report silhouette measurement second clustering. Produce three-cluster partition hc1 obtain silhouette display.","code":"library(csamaDist) data(cnv_log_R) hc1 = hclust(dist(cnv_log_R[1:8,])) hc2 = hclust(bioDist::cor.dist(cnv_log_R[1:8,]), method=\"ward.D2\")  opar = par(no.readonly=TRUE) par(mfrow=c(1,2), mar=c(4,3,1,1)) plot(hc1, main=\"Euc, complete\") plot(hc2, main=\"1-Cor, Ward's D2\") par(opar) assn =  cutree(hc2, h=.25) plot(silhouette( assn, bioDist::cor.dist(cnv_log_R[1:8,])))"},{"path":[]},{"path":"/articles/S3_hypothesis_testing.html","id":"the-fairness-hypothesis","dir":"Articles","previous_headings":"Inference","what":"The fairness hypothesis","title":"S3_inference: Definitions and exercises","text":"Let \\(C_1\\) denote suit top card revealed fair shuffle. can state hypothesis fairness deck repeated draws top card shuffling \\[ H_0: Pr(C_1 = \\heartsuit) = Pr(C_1 = \\diamondsuit) = Pr(C_1 = \\clubsuit) = Pr(C_1 = \\spadesuit) = 1/4 \\] frequentist framework statistical inference, define procedures testing (null) hypotheses specified error probabilities. Type error occurs null hypothesis true test results assertion false. Traditionally try keep probability Type errors 5%. Type II error occurs null hypothesis false test result assertion false. Traditionally try keep probability Type II errors 20%.","code":""},{"path":"/articles/S3_hypothesis_testing.html","id":"exercises","dir":"Articles","previous_headings":"Inference > The fairness hypothesis","what":"Exercises","title":"S3_inference: Definitions and exercises","text":"14: Propose test \\(H_0\\) given . Assume results top card draws 100 shuffles. 15: Consider approach testing \\(H_0\\) basis top card draws \\(N\\) shuffles:","code":""},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":"/articles/S4_hypothesis_testing.html","id":"basic-concepts","dir":"Articles","previous_headings":"Inference","what":"Basic concepts","title":"S4_inference: Definitions and exercises","text":"going focus framework known “null hypothesis significance testing”. “null hypothesis” typically denoted \\(H_0\\) expresses claim often involves lack effect experimental intervention outcome interest. “alternative hypothesis” denoted \\(H_1\\), express specific measurable impact intervention. case card deck chapter S1, typical postulate \\(H_0\\): deck fair, one card combination face suit \\(H_1\\): deck tampered excess hearts Note case, \\(H_1\\) fairly vague – less specific, referring lack fairness. \\(H_1\\) specifies suit excess representation deck, specific severe tampering . experimental design, important clear view sources variation outcome interest, magnitude effect intervention scientifically important. focus can establish operating characteristics proposed experiment. significance testing framework, formalize operating characteristics probabilities inferential error, described . plunge formalities, let’s recall work deck cards. create fair deck: Now let’s create severely biased deck: tools shuffling drawing top card: Let’s make reproducible random draw: Exercise: create vector holding 100 draws biased deck. Estimate probability suit top card diamond. Use test suit draw. example: Note: starting set.seed(2345), estimated probability diamond suit top draw found 0.16.","code":"library(CSHstats) d = build_deck() table(suits(d), faces(d)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 bd = d  # just a copy bd[18] = bd[3] bd[19] = bd[3] bd[20] = bd[4] bd[21] = bd[5] table(suits(bd), faces(bd)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 3 2 2 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 0 0 0 0 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 shuffle_deck = function(d) sample(d, size=length(d), replace=FALSE) top_draw = function(d) shuffle_deck(d)[1] set.seed(1234) t1 = top_draw(bd) t1 ## [1] \"3 ♣\" diamond_sign = function() \"\\U2662\" t1 == diamond_sign() ## [1] FALSE"},{"path":"/articles/S4_hypothesis_testing.html","id":"the-fairness-hypothesis","dir":"Articles","previous_headings":"Inference","what":"The fairness hypothesis","title":"S4_inference: Definitions and exercises","text":"Let \\(C_1\\) denote suit top card revealed fair shuffle. can state hypothesis fairness deck repeated draws top card shuffling \\[ H_0: Pr(C_1 = \\heartsuit) = Pr(C_1 = \\diamondsuit) = Pr(C_1 = \\clubsuit) = Pr(C_1 = \\spadesuit) = 1/4 \\]","code":""},{"path":"/articles/S4_hypothesis_testing.html","id":"operating-characteristics-type-i-and-type-ii-errors","dir":"Articles","previous_headings":"Inference","what":"Operating characteristics: Type I and Type II errors","title":"S4_inference: Definitions and exercises","text":"frequentist framework statistical inference, define procedures testing (null) hypotheses specified error probabilities. Type error occurs null hypothesis true test results assertion false. Traditionally try keep probability Type errors 5%. Type II error occurs null hypothesis false test result assertion false. Traditionally try keep probability Type II errors 20%. Synonyms: often use size synonymous Type error probability, power one minus Type II error probability","code":""},{"path":"/articles/S4_hypothesis_testing.html","id":"exercise","dir":"Articles","previous_headings":"Inference > Operating characteristics: Type I and Type II errors","what":"Exercise","title":"S4_inference: Definitions and exercises","text":"1: Propose procedure testing \\(H_0: Pr(C_1 = \\heartsuit) = 1/4\\). Assume results top card draws N shuffles. procedure look like?","code":""},{"path":"/articles/S4_hypothesis_testing.html","id":"simulating-a-series-of-experiments-parameter-estimate","dir":"Articles","previous_headings":"Inference","what":"Simulating a series of experiments; parameter estimate","title":"S4_inference: Definitions and exercises","text":"100 shuffles estimate probability heart. experimental result consistent \\(H_0\\)? larger sample size:","code":"suppressPackageStartupMessages({ suppressMessages({ library(CSHstats) library(EnvStats) }) }) d = build_deck() shuffle_deck = function(d) sample(d, size=length(d), replace=FALSE) heart_sign = function() \"\\U2661\" set.seed(4141) top_draw = function(d) shuffle_deck(d)[1] N = 100 mydat = replicate(N, suits(top_draw(d))==heart_sign()) phat = function(dat) sum(dat)/length(dat) phat(mydat) ## [1] 0.35 N = 1000 mydat = replicate(N, suits(top_draw(d))==heart_sign()) sum(mydat)/length(mydat) ## [1] 0.243"},{"path":"/articles/S4_hypothesis_testing.html","id":"an-improvised-test","dir":"Articles","previous_headings":"Inference","what":"An improvised test","title":"S4_inference: Definitions and exercises","text":"Let’s use procedure |phat(dat)-.25|>.01 criterion rejecting \\(H_0: Pr(C_1 = \\heartsuit) = 1/4\\) Type error rate fair deck experiment based 100 shuffles? Parameterize “delta”, 0.01 previous run. Let’s get rejection rate estimates two sample sizes: home-cooked test Type error rate much high standard practice, depends sample size.","code":"N = 100 NSIM = 1000 tsts = replicate(NSIM,    abs(mean(replicate(N, suits(top_draw(d))==heart_sign()))-.25)>.01) mean(tsts) ## [1] 0.911 prej = function(delta=.01, nullval=.25, NSIM, N) {  mean(replicate(NSIM,    abs(mean(replicate(N, suits(top_draw(d))==heart_sign()))-nullval)>delta)) } prej(delta=.02, NSIM=1000, N=100) ## [1] 0.655 prej(delta=.02, NSIM=1000, N=500) ## [1] 0.323"},{"path":"/articles/S4_hypothesis_testing.html","id":"a-properly-calibrated-procedure","dir":"Articles","previous_headings":"Inference","what":"A properly calibrated procedure","title":"S4_inference: Definitions and exercises","text":"Let’s instead use built procedure testing hypotheses binomial outcomes. brej function defined two layers: - inner: given N draws, test sum number hearts consistent specified null value (1/4 default), specified Type error rate (argument alpha) - outer: replicate inner process NSIM times obtain NSIM indicator variables taking value 1 test rejected 0 otherwise estimate rejection probabilities taking means indicator variables different experimental replication setups. indication procedure stabilizes Type error rate different designs (sample sizes) can accommodate different significance levels.","code":"brej = function(deck, nullval=.25, alpha=0.05, NSIM, N) {  replicate(NSIM, {    dat = replicate(N, suits(top_draw(deck))==heart_sign())    binom.test(sum(dat), N, nullval)$p.value < alpha    }) } mean(brej(d,NSIM=1000, N=100)) ## [1] 0.054 mean(brej(d,NSIM=1000, N=500)) ## [1] 0.06 mean(brej(d,NSIM=1000, N=100, alpha=0.01)) ## [1] 0.006"},{"path":"/articles/S4_hypothesis_testing.html","id":"power-curve","dir":"Articles","previous_headings":"","what":"Power curve","title":"S4_inference: Definitions and exercises","text":"often useful sketch power test procedure series values element experimental/testing setup. ’ll consider power reject null varies sample size, two alternatives null. make biased deck switching one diamond heart. deck, probability heart 14/52, greater 1/4. kind sample size need get good power detect exception?  two switches, probability heart increases 15/52.  Finally, show null hypothesis (deck fair) rejection rate approximately 0.05 range sample sizes.","code":"bd = d bd[18] = bd[4] table(suits(bd), faces(bd)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 2 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 0 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 ssizes = c(10,50, 100, 300,750) rejps = sapply(ssizes, function(x) mean(brej(bd, NSIM=100, N=x))) plot(ssizes, rejps, main=\"detect one extra heart\") bd[19] = bd[5] table(suits(bd), faces(bd)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 2 2 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 0 0 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 rejps = sapply(ssizes, function(x) mean(brej(bd, NSIM=100, N=x))) plot(ssizes, rejps, main=\"detect two extra hearts\") rejps_n = sapply(ssizes, function(x) mean(brej(d, NSIM=100, N=x))) plot(ssizes, rejps_n, main=\"preserve Type I error rate\", ylim=c(0,1)) abline(h=0.05, lty=2)"},{"path":"/articles/S4_hypothesis_testing.html","id":"conclusions","dir":"Articles","previous_headings":"","what":"Conclusions","title":"S4_inference: Definitions and exercises","text":"Classical frequentist inference aims control probabilities errors Type (reject null hypothesis true) Type II (fail reject false null). power test procedure one minus Type II error probability. case card deck, hypothesis fairness deck shuffling procedure entails probability drawing heart shuffle 1/4 experimental setup entails probability distribution sum number hearts drawn top card N shuffling events binomial(N,1/4) sum number hearts observed, number trials, parameter value defining null hypothesis, desired type error rate, produces critical region using binomial distribution sum falls critical region, null hypothesis rejected Verification achievement desired Type Type II error probabilities testing procedure can pursued via simulation power curve sequence experimental conditions can produced via simulation Analytical tools power computation also available. example, EnvStats package, find exercise reconcile results simulation-based results given . Another find sample size needed achieve 80% power detect single switch diamond heart otherwise fair deck.","code":"library(EnvStats) propTestPower(750, p.or.p1=13/52, p0=.25 ) ## [1] 0.05 propTestPower(750, p.or.p1=14/52, p0=.25 ) ## [1] 0.2348789 propTestPower(750, p.or.p1=15/52, p0=.25 ) ## [1] 0.6742566"},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":"/articles/S5_linear_models.html","id":"error-rates-size-and-power","dir":"Articles","previous_headings":"Review of some inference concepts","what":"Error rates: size and power","title":"S5_inference: FDR, linear models, and GLMs","text":"average value quantity change treatment? changing composition deck cards affect probability seeing given suit drawing card? Type error: reject null actually true Type II error: fail reject null actually false","code":""},{"path":"/articles/S5_linear_models.html","id":"p-value-a-condensation-of-the-data-and-assumptions","dir":"Articles","previous_headings":"Review of some inference concepts","what":"p-value: a condensation of the data and assumptions","title":"S5_inference: FDR, linear models, and GLMs","text":"p-value test probability observing statistic seen experiment extreme value statistic given null hypothesis true. two-sided p-value obtained via results 27 hearts seen, 22 fewer hearts seen “extreme” observed. p-value probability, value reflects uncertainty assessment relation data null hypothesis. Large p-values suggest much reason use data reject null hypothesis; small p-values suggest either null hypothesis false rare event occurred.","code":"binom.test(27, 100, 1/4) ##  ##  Exact binomial test ##  ## data:  27 and 100 ## number of successes = 27, number of trials = 100, p-value = 0.6446 ## alternative hypothesis: true probability of success is not equal to 0.25 ## 95 percent confidence interval: ##  0.1860664 0.3680163 ## sample estimates: ## probability of success  ##                   0.27 sum(dbinom(27:100, 100, .25))+sum(dbinom(1:22,100, .25)) ## [1] 0.6446304"},{"path":"/articles/S5_linear_models.html","id":"confidence-interval-an-alternative-expression-of-uncertainty","dir":"Articles","previous_headings":"Review of some inference concepts","what":"Confidence interval: an alternative expression of uncertainty","title":"S5_inference: FDR, linear models, and GLMs","text":"observed 30 hearts 100 top-card draws, test report : confidence interval random interval derived data property include true value population parameter interest specified probability.  Exercise: value statistic reject null hypothesis probability 1/4 heart? Exercise: Use 99% coverage probability produce display.","code":"binom.test(30, 100, 1/4) ##  ##  Exact binomial test ##  ## data:  30 and 100 ## number of successes = 30, number of trials = 100, p-value = 0.2491 ## alternative hypothesis: true probability of success is not equal to 0.25 ## 95 percent confidence interval: ##  0.2124064 0.3998147 ## sample estimates: ## probability of success  ##                    0.3 stats = c(27:42) tests = lapply(stats, function(x) binom.test(x, 100, .25)) low = sapply(tests, function(x) x$conf.int[1]) hi = sapply(tests, function(x) x$conf.int[2]) ests = sapply(tests, \"[[\", \"statistic\") plot(stats, ests, ylim=c(0, .6), main=\"95% Confidence intervals\", xlab=\"# hearts seen in 100 draws\",   ylab=\"estimated proportion of hearts\") segments( stats, low, stats, hi) abline(h=.25, lty=2)"},{"path":"/articles/S5_linear_models.html","id":"multiple-comparisons","dir":"Articles","previous_headings":"","what":"Multiple comparisons","title":"S5_inference: FDR, linear models, and GLMs","text":"Everything ’ve seen thus far looks single test various ways. hallmark work genomics necessity performing many tests, large number features hypotheses play. Fact: many tests conducted true null hypotheses, distribution collection p-values thereby obtained uniform (0,1]. illustrate produce 10000 samples N(100,1) conduct t test null mean 100, yielding 10000 p-values.  display shows limitation density estimation fixed interval – “boundary effect”, data “” boundary get sparser get closer boundary. consistent property uniform distribution [0,1]: true density 1.","code":"many_x = replicate(10000, rnorm(10, 100)) many_p = apply(many_x, 2, function(x) t.test(x, mu=100)$p.value) plot(density(many_p, from=0, to=1))"},{"path":"/articles/S5_linear_models.html","id":"bonferronis-correction-to-achieve-family-wise-error-rate-fwer-control","dir":"Articles","previous_headings":"Multiple comparisons","what":"Bonferroni’s correction to achieve Family-Wise Error Rate (FWER) control","title":"S5_inference: FDR, linear models, and GLMs","text":"concept Type error general, deployed define operating characteristics kind inference procedure. table frequently seen discussions multiple testing, Holmes Huber’s Modern Statistics Modern Biology. decisiontab Suppose \\(m\\) hypotheses test wish overall probability family tests Type error rate \\(\\alpha\\). Using table symbols, \\(Pr(V>0) < \\alpha\\). Bonferroni’s method declare significance tests \\(p\\)-value less \\(\\alpha/m\\). procedure (related improvements FWER control) also implies transformation \\(p\\)-values, see shortly.","code":""},{"path":"/articles/S5_linear_models.html","id":"false-discovery-rate","dir":"Articles","previous_headings":"Multiple comparisons","what":"False discovery rate","title":"S5_inference: FDR, linear models, and GLMs","text":"Referring table , false discovery rate (FDR) expected value \\(V/max(R,1)\\). \\(R = 0\\), \\(V = 0\\) FDR zero. Otherwise, can think FDR kind budget: reject \\(R\\) hypotheses expection \\(V\\) false. “following ” confirmatory experiments \\(R\\) genes can afford “wasting” \\(V\\) tests, accept FDR \\(V/R\\). course probabilistic characteristics procedures hold stated probabilities assumptions satisfied.","code":""},{"path":"/articles/S5_linear_models.html","id":"adjusted-p-values","dir":"Articles","previous_headings":"Multiple comparisons","what":"Adjusted p-values","title":"S5_inference: FDR, linear models, and GLMs","text":"Since accustomed single-number summary \\(p\\), typical base rejection decisions transformed \\(p\\)-values. multtest package takes care . default, mt.rawp2adp produces number adjustments – concerned present columns rawp (p-values sorted lowest ), Bonferroni (gives transformation \\(p\\) min(1, mp)$ \\(m\\) tests), BH (Benjamini-Hochberg FDR transformation). implication table FWER control 0.05, data support rejection hypotheses (assert mean sample 10 random normals equal 100). Likewise FDR control value 0.77. However, see accepted FDR control 0.8, reject 8 hypotheses. Exercise: replace first p-value many_p 1e-6 obtain associated adjusted p-values.","code":"library(multtest) options(digits=3) tab = mt.rawp2adjp(many_p) head(tab[[1]],10) ##           rawp Bonferroni   Holm Hochberg SidakSS SidakSD     BH    BY    ABH ##  [1,] 1.07e-06     0.0107 0.0107   0.0107  0.0106  0.0106 0.0107 0.104 0.0107 ##  [2,] 7.94e-05     0.7944 0.7943   0.7943  0.5481  0.5481 0.3972 1.000 0.3972 ##  [3,] 2.75e-04     1.0000 1.0000   1.0000  0.9359  0.9359 0.6588 1.000 0.6588 ##  [4,] 3.00e-04     1.0000 1.0000   1.0000  0.9502  0.9502 0.6588 1.000 0.6588 ##  [5,] 3.29e-04     1.0000 1.0000   1.0000  0.9629  0.9629 0.6588 1.000 0.6588 ##  [6,] 5.51e-04     1.0000 1.0000   1.0000  0.9959  0.9959 0.8190 1.000 0.8190 ##  [7,] 5.97e-04     1.0000 1.0000   1.0000  0.9974  0.9974 0.8190 1.000 0.8190 ##  [8,] 7.80e-04     1.0000 1.0000   1.0000  0.9996  0.9996 0.8190 1.000 0.8190 ##  [9,] 9.25e-04     1.0000 1.0000   1.0000  0.9999  0.9999 0.8190 1.000 0.8190 ## [10,] 9.44e-04     1.0000 1.0000   1.0000  0.9999  0.9999 0.8190 1.000 0.8190 ##       TSBH_0.05 ##  [1,]    0.0107 ##  [2,]    0.3971 ##  [3,]    0.6587 ##  [4,]    0.6587 ##  [5,]    0.6587 ##  [6,]    0.8189 ##  [7,]    0.8189 ##  [8,]    0.8189 ##  [9,]    0.8189 ## [10,]    0.8189"},{"path":"/articles/S5_linear_models.html","id":"adjustments-via-weighted-fdr","dir":"Articles","previous_headings":"Multiple comparisons","what":"Adjustments via weighted FDR","title":"S5_inference: FDR, linear models, and GLMs","text":"useful review available. section addresses one methods review, found good performance, though contexts authors’ alternatives appear superior.","code":""},{"path":"/articles/S5_linear_models.html","id":"setup","dir":"Articles","previous_headings":"Multiple comparisons > Adjustments via weighted FDR","what":"Setup","title":"S5_inference: FDR, linear models, and GLMs","text":"need IHW package visualization well. ’s key resource p-values want interpret. variant-expression association tests conducted GTEx project. Thus small excerpt collection “GWAS”, outcome tissue-specific expression gene, predictors formed SNP genotypes adjustments carried GTEx analysis pipeline. ’s composite manhattan plot:","code":"library(CSHstats)  library(ggplot2)  library(plotly)  library(IHW)  library(multtest) data(gtex_exc_chr20_b38) gtdat = gtex_exc_chr20_b38 head(gtdat,3) ##   chr pos_b38       marker         rsid effectallele otherallele    eaf     p ## 1  20   61066 20:61066:T:C rs1031667049            C           T 0.0285 0.774 ## 2  20   61083 20:61083:C:T  rs956068117            T           C 0.1010 0.767 ## 3  20   61098 20:61098:C:T  rs933208784            T           C 0.0155 0.117 ##      beta     se              pheno mode       tag imputersq   n     Gene ## 1  0.0226 0.0784 ENSG00000196476.11 eqtl GTEx-eqtl        NA 515 C20orf96 ## 2  0.0123 0.0413 ENSG00000196476.11 eqtl GTEx-eqtl        NA 515 C20orf96 ## 3 -0.1615 0.1029 ENSG00000196476.11 eqtl GTEx-eqtl        NA 515 C20orf96 ##   seqnames  start    end width strand         gene_id gene_name   gene_biotype ## 1       20 270863 290778 19916      - ENSG00000196476  C20orf96 protein_coding ## 2       20 270863 290778 19916      - ENSG00000196476  C20orf96 protein_coding ## 3       20 270863 290778 19916      - ENSG00000196476  C20orf96 protein_coding ##   seq_coord_system   symbol entrezid ## 1       chromosome C20orf96   140680 ## 2       chromosome C20orf96   140680 ## 3       chromosome C20orf96   140680 pl1 = ggplot(gtdat[gtdat$p<.1,], aes(x=pos_b38, y=-log10(p), colour=Gene)) + geom_point() #ggplotly(pl1) pl1"},{"path":"/articles/S5_linear_models.html","id":"demonstration-1-use-allele-frequency-to-form-strata-for-fdr-weighting","dir":"Articles","previous_headings":"Multiple comparisons > Adjustments via weighted FDR","what":"Demonstration 1: Use allele frequency to form strata for FDR weighting","title":"S5_inference: FDR, linear models, and GLMs","text":"eaf field frequency “effect allele” reported SNP-Nexus. run IHW algorithm using variant frequency strata, conjecture rare common variants may downweighted way advantageous discovery. weighting procedure involves random resampling data, reduce risk overfitting, allow assessment consistency across multiple “folds” random subsets.  Compare weighted, unweighted, conventional rejection numbers:","code":"covariate1 = cut(gtdat$eaf, c(0,.01,.05,.1,.3,.6)) table(covariate1) ## covariate1 ##    (0,0.01] (0.01,0.05]  (0.05,0.1]   (0.1,0.3]   (0.3,0.6]  ##        3865       33697       13860       27840       20738 demo1 = ihw(gtdat$p, covariate1, alpha=0.05) basic_fdr = mt.rawp2adjp(gtdat$p) plot(demo1) newp = adj_pvalues(demo1) sum(newp < 0.05) ## [1] 276 sum(basic_fdr$adjp[,\"BH\"] < 0.05) ## [1] 257 sum(gtdat$p < 5e-8) ## [1] 68"},{"path":"/articles/S5_linear_models.html","id":"demonstration-2-use-distance-to-gene-to-weight","dir":"Articles","previous_headings":"Multiple comparisons > Adjustments via weighted FDR","what":"Demonstration 2: Use distance to gene to weight","title":"S5_inference: FDR, linear models, and GLMs","text":"","code":"dist2gene = abs(gtdat$pos_b38-gtdat$start) covariate2 = cut(dist2gene, 5) ok = which(!is.na(covariate2)) demo2 = ihw(gtdat$p[ok], covariate2[ok], alpha=0.05) plot(demo2) newp2 = adj_pvalues(demo2) sum(newp2 < 0.05) ## [1] 379"},{"path":"/articles/S5_linear_models.html","id":"optional-considerations-on-bayesian-multiple-testing","dir":"Articles","previous_headings":"Multiple comparisons","what":"Optional: Considerations on Bayesian multiple testing","title":"S5_inference: FDR, linear models, and GLMs","text":"Various comments references stackexchange address relationship inferential framework approach multiple testing. paper Gelman Loken surveys concept illuminating way. paper European Journal Epidemiology presents considerations multiple comparisons Bayesian perspective, arguing issue “surrounded confusion controversy”. simple approach visualizing 20 tests, assumed independent, frequenist framework, focusing 95% confidence intervals.  One hypothesis rejected. authors also use bayesm package produce Bayesian credible intervals assumption tests independent.  Finally, allowing high correlatedness among test statistics, Bayesian approach found avoid false rejections.  Bayesian computations involve Monte Carlo Markov Chain simulation. Background can obtained Statistical Rethinking R. McElreath.","code":"# from https://link.springer.com/content/pdf/10.1007/s10654-019-00517-2.pdf # Sjolander and vanSteenlandt 2019 Eur J Epi  library(forestplot) library(bayesm) set.seed(1)  n = 10 J = 20 beta = 0 Y = matrix(rnorm(n*J, mean=beta), nrow=n, ncol=J) est = colMeans(Y) se = apply(X=Y, MARGIN=2, FUN=sd)/sqrt(n) q = qt(p=0.975, df=n-1) ci.l = est-q*se ci.u = est+q*se  forestplot(  labeltext=rep(\"\", J),  mean=est, lower=ci.l,  upper=ci.u, ci.vertices=TRUE,  boxsize=0.3, txt_gp=fpTxtGp(cex=2),  xticks=seq(-1.5,1.5,.5), title=\"Frequentist 95% confidence intervals\") forestplot(  labeltext=rep(\"\", J),  mean=est, lower=ci.l,  upper=ci.u, ci.vertices=TRUE,  boxsize=0.3, txt_gp=fpTxtGp(cex=2),  xticks=seq(-1.5,1.5,.5), title=\"Bayesian, assume correlated tests\")"},{"path":[]},{"path":"/articles/S5_linear_models.html","id":"data-setup","dir":"Articles","previous_headings":"Linear models","what":"Data setup","title":"S5_inference: FDR, linear models, and GLMs","text":"Let’s return TCGA ACC FOS EGR1 data used study correlation.  found log transformation useful ameliorating overplotting near origin:  ACC data annotated MultiAssayExperiment, mutation summary called OncoSign available.","code":"data(fos_ex) data(egr1_ex) fedf = data.frame(FOS=fos_ex, EGR1=egr1_ex) library(ggplot2) ggplot(fedf, aes(x=EGR1, y=FOS)) + geom_point() ggplot(fedf, aes(x=EGR1, y=FOS)) + geom_point() + scale_x_log10() + scale_y_log10() library(MultiAssayExperiment) library(CSHstats) data(accex) accex ## A MultiAssayExperiment object of 1 listed ##  experiment with a user-defined name and respective class. ##  Containing an ExperimentList class object of length 1: ##  [1] ACC_RNASeq2GeneNorm-20160128: SummarizedExperiment with 20501 rows and 79 columns ## Functionality: ##  experiments() - obtain the ExperimentList instance ##  colData() - the primary/phenotype DataFrame ##  sampleMap() - the sample coordination DataFrame ##  `$`, `[`, `[[` - extract colData columns, subset, or experiment ##  *Format() - convert into a long or wide DataFrame ##  assays() - convert ExperimentList to a SimpleList of matrices ##  exportClass() - save data to flat files table(accex$OncoSign, exclude=NULL) ##  ##          CN1          CN2       CTNNB1   TERT/ZNRF3     TP53/NF1 Unclassified  ##            4           13            5           17           21           14  ##         <NA>  ##            5"},{"path":"/articles/S5_linear_models.html","id":"re-expressing-the-two-sample-test","dir":"Articles","previous_headings":"Linear models","what":"Re-expressing the two-sample test","title":"S5_inference: FDR, linear models, and GLMs","text":"focus two OncoSign classes, asking whether average log EGR1 expression different .","code":"hasonc = which(!is.na(accex$OncoSign)) ndf = data.frame(logEGR1 = log(egr1_ex[hasonc]), oncosign=accex$OncoSign[hasonc]) tpvtert = ndf |> dplyr::filter(oncosign %in% c(\"TP53/NF1\", \"TERT/ZNRF3\")) ggplot(tpvtert, aes(y=logEGR1, x=factor(oncosign))) + geom_boxplot()"},{"path":"/articles/S5_linear_models.html","id":"there-are-two-t-tests","dir":"Articles","previous_headings":"Linear models > Re-expressing the two-sample test","what":"There are two t tests","title":"S5_inference: FDR, linear models, and GLMs","text":"","code":"options(digits=6) t.test(logEGR1~oncosign, data=tpvtert, var.equal=TRUE) ##  ##  Two Sample t-test ##  ## data:  logEGR1 by oncosign ## t = 1.038, df = 36, p-value = 0.306 ## alternative hypothesis: true difference in means between group TERT/ZNRF3 and group TP53/NF1 is not equal to 0 ## 95 percent confidence interval: ##  -0.374199  1.158895 ## sample estimates: ## mean in group TERT/ZNRF3   mean in group TP53/NF1  ##                  7.35317                  6.96083 t.test(logEGR1~oncosign, data=tpvtert, var.equal=FALSE) # more general ##  ##  Welch Two Sample t-test ##  ## data:  logEGR1 by oncosign ## t = 1.046, df = 35.19, p-value = 0.303 ## alternative hypothesis: true difference in means between group TERT/ZNRF3 and group TP53/NF1 is not equal to 0 ## 95 percent confidence interval: ##  -0.369343  1.154039 ## sample estimates: ## mean in group TERT/ZNRF3   mean in group TP53/NF1  ##                  7.35317                  6.96083"},{"path":"/articles/S5_linear_models.html","id":"the-linear-model-has-one-of-these-as-a-special-case","dir":"Articles","previous_headings":"Linear models > Re-expressing the two-sample test","what":"The linear model has one of these as a special case","title":"S5_inference: FDR, linear models, and GLMs","text":"general form linear model statistics “dependent variable” \\(y\\) \\[ y = \\alpha + x' \\beta + e \\] \\(x\\) p-vector “covariates” – measurements believed affect mean value \\(y\\), also known “independent variables”, \\(e\\) zero-mean disturbance residual fixed dispersion. parameters interest \\(\\alpha\\) (often called intercept) \\(\\beta\\). Parameter interpretation terms units response relative differences samples different values \\(x\\) always explicit.","code":""},{"path":"/articles/S5_linear_models.html","id":"a-dummy-variable-design-matrix","dir":"Articles","previous_headings":"Linear models > Re-expressing the two-sample test > The linear model has one of these as a special case","what":"A dummy variable design matrix","title":"S5_inference: FDR, linear models, and GLMs","text":"","code":"mm = model.matrix(~oncosign, data=tpvtert) head(mm) ##   (Intercept) oncosignTP53/NF1 ## 1           1                1 ## 2           1                1 ## 3           1                0 ## 4           1                1 ## 5           1                0 ## 6           1                1 tail(mm) ##    (Intercept) oncosignTP53/NF1 ## 33           1                0 ## 34           1                1 ## 35           1                0 ## 36           1                0 ## 37           1                1 ## 38           1                1"},{"path":"/articles/S5_linear_models.html","id":"recovering-the-t-test-with-lm","dir":"Articles","previous_headings":"Linear models > Re-expressing the two-sample test > The linear model has one of these as a special case","what":"Recovering the t test with lm","title":"S5_inference: FDR, linear models, and GLMs","text":"Exercise: t test recovered analysis? Exercise: Conduct associated Wilcoxon test. Exercise: Conduct Gaussian rank test mentioned Gelman blog “Don’t Wilcoxon”. Extra goody: produce coefficients “hand”: programs \\((X'X)^{-1}X'y\\)","code":"tpvtert |> lm(logEGR1~oncosign, data=_) |> summary() ##  ## Call: ## lm(formula = logEGR1 ~ oncosign, data = tpvtert) ##  ## Residuals: ##    Min     1Q Median     3Q    Max  ## -2.287 -0.721  0.167  0.625  2.549  ##  ## Coefficients: ##                  Estimate Std. Error t value Pr(>|t|)     ## (Intercept)         7.353      0.281   26.17   <2e-16 *** ## oncosignTP53/NF1   -0.392      0.378   -1.04     0.31     ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## Residual standard error: 1.16 on 36 degrees of freedom ## Multiple R-squared:  0.0291, Adjusted R-squared:  0.00209  ## F-statistic: 1.08 on 1 and 36 DF,  p-value: 0.306 solve(t(mm)%*%mm)%*%t(mm)%*%tpvtert$logEGR1 ##                       [,1] ## (Intercept)       7.353174 ## oncosignTP53/NF1 -0.392348"},{"path":"/articles/S5_linear_models.html","id":"analysis-of-variance-f-test","dir":"Articles","previous_headings":"Linear models","what":"Analysis of variance: F test","title":"S5_inference: FDR, linear models, and GLMs","text":"analysis variance focused comparison multiple groups. EGR1-OncoSign relationship reasonable example used.","code":"ggplot(ndf, aes(y=logEGR1, x=factor(oncosign))) + geom_boxplot() nda = aov(logEGR1~factor(oncosign), data=ndf) nda ## Call: ##    aov(formula = logEGR1 ~ factor(oncosign), data = ndf) ##  ## Terms: ##                 factor(oncosign) Residuals ## Sum of Squares           11.3084   92.1642 ## Deg. of Freedom                5        68 ##  ## Residual standard error: 1.1642 ## Estimated effects may be unbalanced summary(nda) ##                  Df Sum Sq Mean Sq F value Pr(>F) ## factor(oncosign)  5   11.3    2.26    1.67   0.15 ## Residuals        68   92.2    1.35"},{"path":"/articles/S5_linear_models.html","id":"linear-regression-parameter-estimation-goodness-of-fit","dir":"Articles","previous_headings":"Linear models","what":"Linear regression, parameter estimation, goodness of fit","title":"S5_inference: FDR, linear models, and GLMs","text":"common applications linear modeling take advantage continuity predictor. simple linear regression (one continuous covariate), interpretation \\(\\beta\\) : difference mean \\(y\\) associated unit difference \\(x\\). Regarding log EGR1 predictor log FOS, ","code":"m1 = lm(log(fos_ex)~log(egr1_ex)) summary(m1) ##  ## Call: ## lm(formula = log(fos_ex) ~ log(egr1_ex)) ##  ## Residuals: ##    Min     1Q Median     3Q    Max  ## -1.545 -0.482  0.198  0.476  1.397  ##  ## Coefficients: ##              Estimate Std. Error t value Pr(>|t|)     ## (Intercept)    2.2980     0.4975    4.62  1.5e-05 *** ## log(egr1_ex)   0.6895     0.0692    9.96  1.8e-15 *** ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## Residual standard error: 0.727 on 77 degrees of freedom ## Multiple R-squared:  0.563,  Adjusted R-squared:  0.557  ## F-statistic: 99.1 on 1 and 77 DF,  p-value: 1.75e-15 plot(m1)"},{"path":[]},{"path":"/articles/S5_linear_models.html","id":"glms-binary-counted-non-gaussian-responses","dir":"Articles","previous_headings":"","what":"GLMs: binary, counted, non-Gaussian responses","title":"S5_inference: FDR, linear models, and GLMs","text":"family generalized linear models (GLM) embraces number approaches statistical inference associations non-Gaussian responses general configurations covariates.","code":""},{"path":"/articles/S5_linear_models.html","id":"prologue-fishers-exact-test-for-2-x-2-table","dir":"Articles","previous_headings":"GLMs: binary, counted, non-Gaussian responses","what":"Prologue: Fisher’s exact test for 2 x 2 table","title":"S5_inference: FDR, linear models, and GLMs","text":"’ll work FOS EGR1 artificial way. ’ll suppose criteria “activation”: FOS activated RNA-seq measurement ACC exceeds 1000 EGR1 activated RNA-seq measurement ACC exceeds 2000 form 2 x 2 cross classification tumors using definitions: basic question whether two events “EGR1 activated” “FOS activated” statistically associated ACC tumors. Fisher’s exact test evaluates hypergeometric distribution (1,1) cell table, given marginal totals. odds event occurs probability \\(p\\) given \\(p/(1-p)\\). Abbreviate \\(odds(p)\\) odds ratio two events probabilities \\(p_1\\) \\(p_2\\) \\(odds(p_1)/odds(p_2)\\). 2x2 table can estimated cross ratio “ad/bc”. odds ratio estimated fisher.test different, conditional maximum likelihood estimate. difference seldom meaningful.","code":"library(CSHstats) data(fos_ex) data(egr1_ex) fos_act = 1*(fos_ex > 1000) egr1_act = 1*(egr1_ex > 2000) acttab = table(fos_act=fos_act, egr1_act=egr1_act) acttab ##        egr1_act ## fos_act  0  1 ##       0 26  5 ##       1 25 23 fisher.test(acttab, alternative=\"greater\") # one-sided ##  ##  Fisher's Exact Test for Count Data ##  ## data:  acttab ## p-value = 0.0034 ## alternative hypothesis: true odds ratio is greater than 1 ## 95 percent confidence interval: ##  1.68701     Inf ## sample estimates: ## odds ratio  ##    4.69113 sum(dhyper(26:31, 51, 28, 31)) ## [1] 0.00339765 odds = function(x) {p=mean(x); p/(1-p)} odds(fos_act[egr1_act==TRUE])/odds(fos_act[egr1_act==FALSE]) ## [1] 4.784 acttab[1,1]*acttab[2,2]/(acttab[1,2]*acttab[2,1]) ## [1] 4.784"},{"path":"/articles/S5_linear_models.html","id":"binary-response-logistic-regression","dir":"Articles","previous_headings":"GLMs: binary, counted, non-Gaussian responses","what":"Binary response: logistic regression","title":"S5_inference: FDR, linear models, and GLMs","text":"model conditional probability FOS activated, depending whether note EGR1 activated, using definitions given . model form \\[ \\mbox{logit} Pr(FOS > 1000|EGR1>2000) = \\alpha + \\beta x \\] logit(p) = log(p/(1-p)) called “link function”. transforms outcome interest (probability) interval (0,1) whole real line. interpretation \\(\\beta\\) : “log odds ratio”. exponentiate beta, obtain effect change x one unit odds response event. Parameter interpretation. intercept parameter value -0.0392, logit probability FOS activated, given EGR1 activated. “beta” parameter log odds ratio (comparing probability FOS activation EGR1 conditions – activated activated).","code":"g1 = glm(fos_act ~ egr1_act, family=binomial()) summary(g1) ##  ## Call: ## glm(formula = fos_act ~ egr1_act, family = binomial()) ##  ## Coefficients: ##             Estimate Std. Error z value Pr(>|z|)    ## (Intercept)  -0.0392     0.2801   -0.14   0.8886    ## egr1_act      1.5653     0.5673    2.76   0.0058 ** ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## (Dispersion parameter for binomial family taken to be 1) ##  ##     Null deviance: 105.830  on 78  degrees of freedom ## Residual deviance:  96.958  on 77  degrees of freedom ## AIC: 101 ##  ## Number of Fisher Scoring iterations: 3 log(4.784) ## [1] 1.56528"},{"path":"/articles/S5_linear_models.html","id":"multiple-logistic-regression","dir":"Articles","previous_headings":"GLMs: binary, counted, non-Gaussian responses","what":"Multiple logistic regression","title":"S5_inference: FDR, linear models, and GLMs","text":"Fisher’s exact test simple logistic regression seen consistent one another example. advantage logistic regression framework potential sources variation probability response can incorporated. data YY1 expression ACC declare activated expressed level greater 1500. inclusion information YY1 seem informative FOS activation.","code":"data(yy1_ex) yy1_act = yy1_ex > 1500 g2 = glm(fos_act ~ egr1_act+yy1_act, family=binomial()) summary(g2) ##  ## Call: ## glm(formula = fos_act ~ egr1_act + yy1_act, family = binomial()) ##  ## Coefficients: ##             Estimate Std. Error z value Pr(>|z|)    ## (Intercept)   0.0922     0.3175    0.29   0.7716    ## egr1_act      1.5690     0.5702    2.75   0.0059 ** ## yy1_actTRUE  -0.4833     0.5472   -0.88   0.3771    ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## (Dispersion parameter for binomial family taken to be 1) ##  ##     Null deviance: 105.830  on 78  degrees of freedom ## Residual deviance:  96.177  on 76  degrees of freedom ## AIC: 102.2 ##  ## Number of Fisher Scoring iterations: 3"},{"path":"/articles/S5_linear_models.html","id":"general-case-link-and-variance-functions","dir":"Articles","previous_headings":"GLMs: binary, counted, non-Gaussian responses","what":"General case: link and variance functions","title":"S5_inference: FDR, linear models, and GLMs","text":"family generalized linear models can accommodate many forms variation response interest, associated number “predictor” variables. DESeq2 edgeR use negative binomial GLM inference differential expression RNA-seq. hear much . glm.nb function MASS package allows fit negative binomial regressions data data.frames.","code":"kable(glmtab)"},{"path":"/articles/S5_linear_models.html","id":"hierarchical-models-alternatives-to-independence","dir":"Articles","previous_headings":"","what":"Hierarchical models: alternatives to independence","title":"S5_inference: FDR, linear models, and GLMs","text":"strong assumption use linear generalized linear models mutual independence reponses. clustering responses present (example, analyzing data collected human families, pairs eyes, mice litters), additional model structure introduced accommodate lack independence.","code":""},{"path":"/articles/S5_linear_models.html","id":"random-effects-models-for-clustered-observations","dir":"Articles","previous_headings":"Hierarchical models: alternatives to independence","what":"Random effects models for clustered observations","title":"S5_inference: FDR, linear models, and GLMs","text":"framework approach developed 1982 (Laird Ware) expands linear model model known “mixed effects”: \\[ y_{ij} = \\alpha + \\beta x_{ij} + a_i + e_{ij} \\] \\(\\) indexing clusters \\(j\\) responses within clusters. “random effect” \\(a_i\\) assumed follow \\(N(0, \\sigma^2_b)\\) (-cluster variance), independent \\(e_{ij} \\sim N(0, \\sigma^2_w)\\). intraclass correlation coefficient measures departure independence, form \\(\\rho = \\sigma^2_b/(\\sigma^2_b + \\sigma^2_w)\\). Approximate mixed effects models GLM families can fit using glmmPQL MASS.","code":""},{"path":"/articles/S5a_lmdiagnostics.html","id":"fast-forward","dir":"Articles","previous_headings":"","what":"Fast forward","title":"S5a: Diagnostics of a differential gene expression exercise","text":"document shows SRP045638 can retrieved analyzed. start filtered normalized data vGene object. model matrix also important: top results limma-voom analysis: little different de_results computed class document – sort p take significant results.","code":"library(edgeR) library(CSHstats) data(vGene) names(vGene) ## [1] \"genes\"   \"targets\" \"E\"       \"weights\" \"design\" head(vGene$E[,1:5]) ##                   SRR2071341  SRR2071345 SRR2071346 SRR2071347 SRR2071348 ## ENSG00000223972.5 -1.6548376 -3.43059162 -3.3104740  -2.641761 -3.9493303 ## ENSG00000278267.1 -0.6717114 -0.19793086 -0.5977559  -2.156334  0.1381326 ## ENSG00000227232.5  3.7573137  4.60832737  4.2686324   3.335519  4.5823511 ## ENSG00000284332.1 -5.4961399 -5.75251971 -6.4803990  -4.963689 -7.6497700 ## ENSG00000243485.5 -0.3668569 -0.02459926 -0.6475089  -3.378727  0.6310008 ## ENSG00000237613.2 -5.4961399 -3.43059162 -4.1584709  -2.641761 -6.0648075 data(mod) head(mod) ##            (Intercept) prenatalprenatal sra_attribute.RIN sra_attribute.sexmale ## SRR2071341           1                0               8.3                     0 ## SRR2071345           1                0               8.4                     1 ## SRR2071346           1                0               8.7                     1 ## SRR2071347           1                0               5.3                     0 ## SRR2071348           1                1               9.6                     0 ## SRR2071349           1                1               6.4                     0 ##            assigned_gene_prop ## SRR2071341          0.4376474 ## SRR2071345          0.7776021 ## SRR2071346          0.8054366 ## SRR2071347          0.8374639 ## SRR2071348          0.6956363 ## SRR2071349          0.6855766 data(de_results) options(digits=3) de_results[1:5, c(\"gene_name\", \"logFC\", \"t\", \"P.Value\", \"adj.P.Val\")] ##                    gene_name logFC    t  P.Value adj.P.Val ## ENSG00000121210.15  KIAA0922  3.28 41.9 4.24e-49  1.99e-44 ## ENSG00000143494.15     VASH2  5.44 37.9 2.56e-46  6.01e-42 ## ENSG00000176371.13    ZSCAN2  2.74 36.6 2.14e-45  3.34e-41 ## ENSG00000196150.13    ZNF250  2.51 35.7 1.07e-44  1.25e-40 ## ENSG00000103044.10      HAS3  2.49 35.1 2.69e-44  2.53e-40"},{"path":"/articles/S5a_lmdiagnostics.html","id":"assessing-the-association-by-hand","dir":"Articles","previous_headings":"","what":"Assessing the association “by hand”","title":"S5a: Diagnostics of a differential gene expression exercise","text":"vGene$E structure holds estimated expression values, vGene$weights quantities measure relative variability quantities E. can pick gene interest examine marginal distribution estimate association. top DE gene “ENSG00000121210.15”. Let’s make data.frame E values, covariates, weights. Now examine marginal distribution:  Interesting. ’s big gap KIAA0922 expression distribution. Exercise: true “raw” data, artifact computations ’ve done?  Finally, fit linear model:","code":"target = \"ENSG00000121210.15\" ind = which(rownames(vGene$E)==target) mydf = data.frame(cbind(KIAA0922=vGene$E[ind,],       mod[,-1], wts=vGene$weights[ind,])) hist(mydf$KIAA0922) library(beeswarm) beeswarm(mydf$KIAA0922, pwcol=as.numeric(factor(mydf$prenatalprenatal))) legend(.6,6,legend=c(\"postnatal\", \"prenatal\"), col=c(1,2), pch=19) m1 = lm(KIAA0922~.-wts, data=mydf, weights=wts) summary(m1) ##  ## Call: ## lm(formula = KIAA0922 ~ . - wts, data = mydf, weights = wts) ##  ## Weighted Residuals: ##     Min      1Q  Median      3Q     Max  ## -1.2228 -0.2991 -0.0211  0.3462  1.2114  ##  ## Coefficients: ##                       Estimate Std. Error t value Pr(>|t|)     ## (Intercept)            3.10928    0.34095    9.12  6.2e-13 *** ## prenatalprenatal       3.28305    0.07267   45.18  < 2e-16 *** ## sra_attribute.RIN     -0.00449    0.03444   -0.13   0.8968     ## sra_attribute.sexmale  0.10582    0.06705    1.58   0.1197     ## assigned_gene_prop    -0.96639    0.28639   -3.37   0.0013 **  ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## Residual standard error: 0.547 on 60 degrees of freedom ## Multiple R-squared:  0.973,  Adjusted R-squared:  0.971  ## F-statistic:  545 on 4 and 60 DF,  p-value: <2e-16 plot(m1, which=2, col=(as.numeric(mydf$prenatalprenatal)+1), pch=19)"},{"path":"/articles/S5b_nonlin.html","id":"logistic-curve-with-response-decreasing-in-x","dir":"Articles","previous_headings":"","what":"Logistic curve with response decreasing in x","title":"S5b: hypothesis testing in nonlinear regression","text":"Let denote asymptotic response large values x b denote response x=0. c denote slope-like parameter, d midpoint transition asymptotes.  variety S-shaped curves can produced depending choices parameters. Exercise: Increase value parameter c, recompute y, overlay plot lines() lty=2.","code":"a = 4 b = 1 c = 0.8 d = 4.5 x = 0:10 y = a + (b-a)/(1+exp(-c*(x-d))) plot(x,y,type=\"b\", ylim=c(0,5))"},{"path":"/articles/S5b_nonlin.html","id":"fitting-the-model-to-data","dir":"Articles","previous_headings":"","what":"Fitting the model to data","title":"S5b: hypothesis testing in nonlinear regression","text":"nls function can fit model. data crafted illustrate “pair” curves can regarded shifted instances common shape. color distinguishes elements pair.  modeling pair experiments red points arise different condition black points. null hypothesis curves identical tested using parameter ‘del’ measuring shift response curve. indicator variable z takes value 0 control condition 1 active treatment. Let’s use model overlay predicted response curves original data.  summary, evidence shift, location inflection point shifted 0.24 units x, p-value 0.079. seems clear model fits one condition much better . Exercise: abline function can used sketch aspects model plot just given. example, abline(h=4.4419, lty=2) draws dashed line representing fitted upper asymptote. Use estimated , b, d parameters draw “cross-hairs” showing location inflection point black curve, filling appropriate values abline(v=?, h=?). Exercise (advanced): Test hypothesis two conditions different asymptotic values x increases.","code":"library(CSHstats) data(nonlindat) plot(y~x,data=nonlindat, col=nonlindat$z+1, pch=19) nl1 <- nls(y ~   a + ((b - a)/(1 + exp(-c * (x - d*(1+del*z))))),   start = list(a = min(y), b = max(y), c = 1,   d = round(median(x)), del=0), data=nonlindat) summary(nl1) ##  ## Formula: y ~ a + ((b - a)/(1 + exp(-c * (x - d * (1 + del * z))))) ##  ## Parameters: ##     Estimate Std. Error t value Pr(>|t|)     ## a     4.4419     0.6008   7.393 1.37e-05 *** ## b     0.4829     0.9835   0.491 0.633037     ## c     0.7281     0.4401   1.654 0.126290     ## d     4.3314     0.7326   5.912 0.000101 *** ## del   0.2412     0.1244   1.939 0.078521 .   ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## Residual standard error: 0.4515 on 11 degrees of freedom ##  ## Number of iterations to convergence: 14  ## Achieved convergence tolerance: 4.653e-06 plot(y~x,data=nonlindat, col=nonlindat$z+1, pch=19) nd = data.frame(x=1:8,z=0) y1 = predict(nl1, newdata=nd) lines(1:8, y1, lty=2) nd2 = data.frame(x=1:8,z=1) y2 = predict(nl1, newdata=nd2) lines(1:8, y2, lty=2, col=\"red\")"},{"path":"/articles/S6_hca_onto.html","id":"road-map","dir":"Articles","previous_headings":"","what":"Road map","title":"S6 HCA, ontologies, shiny","text":"Bioconductor reads paper ontoProc rols help ontologies shiny helps communicate","code":""},{"path":"/articles/S6_hca_onto.html","id":"a-paper-on-the-atlas-of-the-prostate","dir":"Articles","previous_headings":"","what":"A paper on the atlas of the prostate","title":"S6 HCA, ontologies, shiny","text":"overview normals","code":""},{"path":[]},{"path":"/articles/S6_hca_onto.html","id":"surveying-projects-of-the-hca","dir":"Articles","previous_headings":"A paper on the atlas of the prostate > The hca package","what":"Surveying projects of the HCA","title":"S6 HCA, ontologies, shiny","text":"","code":"library(hca) p = projects(size = 200); p = dplyr::bind_rows(p, hca_next(p)) # workaround bug upstream to 1.4.0 library(DT) datatable(as.data.frame(p))"},{"path":"/articles/S6_hca_onto.html","id":"picking-a-project-enumerating-and-downloading-loom-files","dir":"Articles","previous_headings":"A paper on the atlas of the prostate > The hca package","what":"Picking a project; Enumerating and downloading loom files","title":"S6 HCA, ontologies, shiny","text":"","code":"projectId = \"53c53cd4-8127-4e12-bc7f-8fe1610a715c\" file_filter <- filters(     projectId = list(is = projectId),     fileFormat = list(is = \"loom\") ) pfile = files(file_filter) pfile$projectTitle[1] ## [1] \"A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra\" #pfile |> files_download()"},{"path":"/articles/S6_hca_onto.html","id":"working-with-loom","dir":"Articles","previous_headings":"A paper on the atlas of the prostate > The hca package","what":"Working with loom","title":"S6 HCA, ontologies, shiny","text":"superficial filtering (60000 cells) development PCA Whatchaget:","code":"library(LoomExperiment) f1 = import(\"/home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom\") f1 names(colData(f1)) library(scater) sf1 = as(f1, \"SingleCellExperiment\") sf1 library(scuttle) assay(sf1[1:4,1:4]) assayNames(sf1) = \"counts\" litsf1 = sf1[,1:60000] z = DelayedArray::rowSums(assay(litsf1)) mean(z==0) todrop = which(z==0) litsf2 = litsf1[-todrop,] assay(litsf2) litsf2 = logNormCounts(litsf2) litsf2 = runPCA(litsf2) library(SingleCellExperiment) if (!exists(\"litsf2\")) load(\"litsf2.rda\") # run code above, must have HDF5 in cache metadata(litsf2) ## $last_modified ## [1] \"20210616T032315.280827Z\" ##  ## $CreationDate ## [1] \"20210616T030548.106180Z\" ##  ## $LOOM_SPEC_VERSION ## [1] \"3.0.0\" ##  ## $expression_data_type ## [1] \"exonic\" ##  ## $input_id ## [1] \"5012cf4f-ba5c-4928-aea1-ab2891e34323\" ##  ## $input_id_metadata_field ## [1] \"sequencing_process.provenance.document_id\" ##  ## $input_name ## [1] \"D27PrTzF_Edn\" ##  ## $input_name_metadata_field ## [1] \"sequencing_input.biomaterial_core.biomaterial_id\" ##  ## $optimus_output_schema_version ## [1] \"1.0.0\" ##  ## $pipeline_version ## [1] \"Optimus_v4.2.3\" > str(litsf2) # 22MB on disk (no quantifications) Formal class 'DelayedMatrix' [package \"DelayedArray\"] with 1 slot   ..@ seed:Formal class 'DelayedAperm' [package \"DelayedArray\"] with 2 slots   .. .. ..@ perm: int [1:2] 2 1   .. .. ..@ seed:Formal class 'DelayedSubset' [package \"DelayedArray\"] with 2 slots   .. .. .. .. ..@ index:List of 2   .. .. .. .. .. ..$ : int [1:60000] 1 2 3 4 5 6 7 8 9 10 ...   .. .. .. .. .. ..$ : int [1:23420] 13 20 22 23 31 33 34 35 36 37 ...   .. .. .. .. ..@ seed :Formal class 'HDF5ArraySeed' [package \"HDF5Array\"] with 7 slots   .. .. .. .. .. .. ..@ filepath : chr \"/home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom\"   .. .. .. .. .. .. ..@ name     : chr \"/matrix\"   .. .. .. .. .. .. ..@ as_sparse: logi FALSE   .. .. .. .. .. .. ..@ type     : chr NA   .. .. .. .. .. .. ..@ dim      : int [1:2] 382197 58347   .. .. .. .. .. .. ..@ chunkdim : int [1:2] 64 64   .. .. .. .. .. .. ..@ first_val: int 0 stvjc@stvjc-XPS-13-9300:~/CSAMA_HCA$ ls -tl /home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom -rw-rw-r-- 1 stvjc stvjc 1206062245 Jun 21 22:37 /home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom"},{"path":"/articles/S6_hca_onto.html","id":"working-with-isee","dir":"Articles","previous_headings":"A paper on the atlas of the prostate > The hca package","what":"Working with iSEE","title":"S6 HCA, ontologies, shiny","text":"Question: “stop/exit” button? Question: can embed iSEE (components) vignette? iSEE server? context fgf2","code":""},{"path":"/articles/S6_hca_onto.html","id":"upshots","dir":"Articles","previous_headings":"A paper on the atlas of the prostate","what":"Upshots","title":"S6 HCA, ontologies, shiny","text":"easy survey HCA hca package easy get experiments, metadata, quantifications projects interest iSEE really accelerates exploration elaboration data claims","code":""},{"path":[]},{"path":"/articles/S6_hca_onto.html","id":"definition-from-wikipedia","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"Definition: from Wikipedia","title":"S6 HCA, ontologies, shiny","text":"computer science information science, ontology encompasses representation, formal naming, definition categories, properties, relations concepts, data, entities substantiate one, many, domains discourse. simply, ontology way showing properties subject area related, defining set concepts categories represent subject. Every academic discipline field creates ontologies limit complexity organize data information knowledge. uses ontological assumptions frame explicit theories, research applications. New ontologies may improve problem solving within domain. Translating research papers within every field problem made easier experts different countries maintain controlled vocabulary jargon languages.","code":""},{"path":"/articles/S6_hca_onto.html","id":"applications-in-genomics","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"Applications in genomics","title":"S6 HCA, ontologies, shiny","text":"Gene Ontology: Genes gene products subdomains BP, MF, CC – biological process, molecular function, cellular component Human Phenotype Ontology UBERON - cross-species anatomy Cell ontology Cell line ontology EFO - experimental factor ontology Tags can encountered various annotation resources.","code":""},{"path":"/articles/S6_hca_onto.html","id":"rols-basic-idea","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"rols: Basic idea","title":"S6 HCA, ontologies, shiny","text":"OLS ontology lookup service API rols package help interrogate service ontologies everywhere","code":""},{"path":"/articles/S6_hca_onto.html","id":"learn-about-smooth-muscle-with-rols","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"Learn about ‘smooth muscle’ with rols","title":"S6 HCA, ontologies, shiny","text":"","code":"library(rols) ss = OlsSearch(\"smooth muscle\", rows=100) ss ## Object of class 'OlsSearch': ##   query: smooth muscle  ##   requested: 100 (out of 50306) ##   response(s): 0 tt = olsSearch(ss) dd = as(tt, \"data.frame\") datatable(dd)"},{"path":"/articles/S6_hca_onto.html","id":"ontoproc-capitalizing-on-ontologyindex-thanks-daniel-greene-rgraphviz-thanks-kasper-hansen","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"ontoProc – capitalizing on ontologyIndex (thanks Daniel Greene!), Rgraphviz (thanks Kasper Hansen!)","title":"S6 HCA, ontologies, shiny","text":"ctmarks app: walk linked ontologies PR present additional facets concept focus Limitation: OBO representation use outdated -links sparse Projects: - use rols get interesting information terms app - update ontology resources - go beyond OBO … way OWL? Evaluate UI/UX needed broaden ontology usage - impacts: data integration, precision annotation, cognitive efficiency","code":"library(ontoProc) co = getOnto(\"cellOnto\") ## loading from cache head(co$name) ##              BFO:0000002              BFO:0000003              BFO:0000004  ##             \"continuant\"              \"occurrent\" \"independent continuant\"  ##              BFO:0000006              BFO:0000015              BFO:0000016  ##         \"spatial region\"                \"process\"            \"disposition\" chk = ctmarks(co)"},{"path":[]},{"path":"/articles/S7_cnn.html","id":"introductory-remarks","dir":"Articles","previous_headings":"","what":"Introductory remarks","title":"S7 Neural net concepts and applications","text":"learning nonlinear regression model putting use input, output, loss function excellent high level overview comparing convolutional neural nets autoencoders","code":""},{"path":"/articles/S7_cnn.html","id":"road-map","dir":"Articles","previous_headings":"","what":"Road map","title":"S7 Neural net concepts and applications","text":"ImageArray also python version ISLR also see Jeremy Jordan explanations Sfaira model zoo embeddings classifiers","code":""},{"path":"/articles/S7_cnn.html","id":"images-and-categories","dir":"Articles","previous_headings":"","what":"Images and categories","title":"S7 Neural net concepts and applications","text":"can filter ImageArray  Question bias: machine recognize orange just “orange” color distribution? “normalize” images “object ” presents “essential features”?","code":"library(littleDeep) data(ciftrain1k) ciftrain1k ## ImageArray instance with 1000 images, each 32 x 32 x 3 ##  Image types: possum lion ... caterpillar girl  ##  Array elements range from 0.000000 to 255.000000. n <- preview(ciftrain1k) preview(filterByType(ciftrain1k, \"orange\")) ## NULL"},{"path":"/articles/S7_cnn.html","id":"a-trained-classifier-that-ingests-jpgs-as-arrays-and-returns-scores-for-resemblance-to","dir":"Articles","previous_headings":"","what":"A trained classifier that ingests JPGs as arrays and returns scores for resemblance to","title":"S7 Neural net concepts and applications","text":"pre-trained categories Check ’ll demonstrate ‘jpeg_shrinker’ installed intel macs M1 macs time. program convert jpeg image 32x32 resolution use trained CNN classify content.","code":"islr_cnn ## function (iarr, nEpochs = 30, batchSize = 128, valSplit = 0.2)  ## { ##     reticulate::import(\"keras\") ##     ca = match.call() ##     stopifnot(inherits(iarr, \"ImageArray\")) ##     arr = getArray(iarr) ##     d = dim(arr)[-1] ##     stopifnot(all(d == c(32, 32, 3))) ##     denom = max(arr) ##     yclass = getTypes(iarr) ##     yclass = as.numeric(factor(yclass)) ##     yclass = yclass - min(yclass) ##     trainxy = list(train = list(x = arr, y = yclass)) ##     ncat = length(unique(trainxy$train$y)) ##     model <- keras_model_sequential() %>% layer_conv_2d(filters = 32,  ##         kernel_size = c(3, 3), padding = \"same\", activation = \"relu\",  ##         input_shape = c(32, 32, 3)) %>% layer_max_pooling_2d(pool_size = c(2,  ##         2)) %>% layer_conv_2d(filters = 64, kernel_size = c(3,  ##         3), padding = \"same\", activation = \"relu\") %>% layer_max_pooling_2d(pool_size = c(2,  ##         2)) %>% layer_conv_2d(filters = 128, kernel_size = c(3,  ##         3), padding = \"same\", activation = \"relu\") %>% layer_max_pooling_2d(pool_size = c(2,  ##         2)) %>% layer_conv_2d(filters = 256, kernel_size = c(3,  ##         3), padding = \"same\", activation = \"relu\") %>% layer_max_pooling_2d(pool_size = c(2,  ##         2)) %>% layer_flatten() %>% layer_dropout(rate = 0.5) %>%  ##         layer_dense(units = 512, activation = \"relu\") %>% layer_dense(units = ncat,  ##         activation = \"softmax\") ##     model %>% compile(loss = \"categorical_crossentropy\", optimizer = optimizer_rmsprop(),  ##         metrics = c(\"accuracy\")) ##     history <- model %>% fit(trainxy$train$x/denom, to_categorical(trainxy$train$y,  ##         ncat), epochs = nEpochs, batch_size = batchSize, validation_split = valSplit) ##     curver = packageVersion(\"littleDeep\") ##     ans = list(model = model, history = history, typelevels = typelevels(iarr),  ##         littleDeepVersion = curver, call = ca, date = Sys.Date()) ##     class(ans) = c(\"islr_cnn\", \"list\") ##     ans ## } ## <bytecode: 0x557d3ee09510> ## <environment: namespace:littleDeep>"},{"path":"/articles/S7_cnn.html","id":"sfaira-a-model-zoo-of-pretrained-embedders-and-cell-type-classifiers-from-theis-lab","dir":"Articles","previous_headings":"","what":"Sfaira: a model zoo of pretrained embedders and cell-type classifiers from Theis Lab","title":"S7 Neural net concepts and applications","text":"’ll look pkgdown site, specifically “get started” tab.","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Road map","title":"distances, nearest-neighbor graphs, clustering","text":"Distances high-dimensional spaces Criteria agglomerative clustering interactive heatmap comparing Euclidean correlation (1-cor) distances comparing agglomeration methods silhouette measure clustering adequacy bluster tools cluster diagnostics Grun pancreas data NNGraphParam","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Cluster analysis concepts","title":"distances, nearest-neighbor graphs, clustering","text":"need identify groups similar observations arises many contexts – ultimately service clarifying sources variability, building power statistical comparisons. Hierarchical clustering N multivariate observations conducted starting N clusters proceeding M clusters M-1 (M=N, …, 2) clusters merging two members separated least pairwise distances.","code":""},{"path":[]},{"path":[]},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Application: inferring steps in tumor metastasis in a breast cancer patient","title":"distances, nearest-neighbor graphs, clustering","text":"’ll examine data distributed 2021 Genome Biology paper Gabor Marth lab. Clinical sequence interventions. Event sequence.","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"A view of copy number aberrations for 1Mb tiling","title":"distances, nearest-neighbor graphs, clustering","text":"28 tumors sampled sequenced rapid autopsy procedure. Copy number variation assessed using FACETS. tissues tumors taken Br (Breast), Bo (Bone), Bn (Brain), Ln (Lung), Lv (Liver), Pa (Pancreas), Ly (Lymph nodes), Kd (Kidney) plotly-based visualization (vertical) ordering tissues chosen exemplify certain similarities. example block blue chr10 seen three samples. indication deletion.","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"A cluster analysis proposed in support of the evolutionary map","title":"distances, nearest-neighbor graphs, clustering","text":"code lightly modified script distributed https://github.com/xiaomengh/tumor-evo-rapid-autopsy.git.","code":"suppressPackageStartupMessages({  library(csamaDist)  library(bioDist)  library(bluster)  library(cluster)  library(scater)  library(scran)  library(scRNAseq)  library(scuttle) }) data(cnv_log_R) data = cnv_log_R samples = c('Ln7','Ln9','Ln1','BrM','BrP',            'Ln11','Ly2','Ln3',            'Bo3','Ln10','Bo1','Ln8','Lv3','Ln5','Bo2','Bn2','Bn1','Bn3','Bn4','Ln2',            'Ly1','Ln6',            'Kd1','Ln4','Lv4','Lv2','Lv1','Pa1') rownames(data) = samples d = dist(data, method=\"euclidean\") fit = hclust(d, method=\"average\") # the following line changes the order of the samples to produce the Fig.S3B but doesn't change the phylogenetic relationship fit$order = c(1,4,2,5,3,13,10,20,16,11,12,15,9,17,19,14,18,21,22,7,6,8,25,27,26,28,23,24) plot(fit)"},{"path":[]},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"Comparing Euclidean and Correlation distances","title":"distances, nearest-neighbor graphs, clustering","text":"given correlation distance value, can wide variation euclidean distance, vice versa. Open question: distance metric relevant biological interpretation CNV?","code":"cd = cor.dist(cnv_log_R) # from bioDist ed = dist(cnv_log_R) plot(as.numeric(ed), as.numeric(cd), xlab=\"All pairwise Euclidean distances\", ylab=\"All pairwise correlation distances\")"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"A pair with discrepant correlation and euclidean distance values (over entire genome)","title":"distances, nearest-neighbor graphs, clustering","text":"’ll look first 100Mb chr1.","code":"plot(cnv_log_R[\"Ly1\",1:100],pch=19, main=\"chr1, first 100Mb\", ylab=\"FACETS CNV log R\", xlab=\"chr1\") points(cnv_log_R[\"Ln1\",1:100], col=\"red\",pch=19) legend(60, -.5, pch=19, col=c(\"black\", \"red\"), legend=c(\"Ly1\", \"Ln1\")) #cor(cnv_log_R[\"Ly1\", 1:100], cnv_log_R[\"Ln1\", 1:100]) edist = function(x,y) sqrt(sum((x-y)^2)) edist(cnv_log_R[\"Ly1\", 1:100], cnv_log_R[\"Ln1\", 1:100]) ## [1] 1.685992 plot(jitter(cnv_log_R[\"Ly1\", 1:100]), cnv_log_R[\"Ln1\", 1:100], xlab=\"Ly1\", ylab=\"Ln1\") abline(0,1)"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"Redo clustering with alternative distance and agglomeration method","title":"distances, nearest-neighbor graphs, clustering","text":"","code":"fit2 = hclust(cd, method=\"ward.D2\") plot(fit2) abline(h=.3, lty=2)"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"Silhouette measure","title":"distances, nearest-neighbor graphs, clustering","text":"?silhouette cluster library:","code":"For each observation i, the _silhouette width_ s(i) is defined as follows:       Put a(i) = average dissimilarity between i and all other points of      the cluster to which i belongs (if i is the _only_ observation in      its cluster, s(i) := 0 without further calculations).  For all      _other_ clusters C, put d(i,C) = average dissimilarity of i to all      observations of C.  The smallest of these d(i,C) is b(i) := \\min_C      d(i,C), and can be seen as the dissimilarity between i and its      \"neighbor\" cluster, i.e., the nearest one to which it does _not_      belong.  Finally,                     s(i) := ( b(i) - a(i) ) / max( a(i), b(i) ).                     'silhouette.default()' is now based on C code donated by Romain      Francois (the R version being still available as      'cluster:::silhouette.default.R').       Observations with a large s(i) (almost 1) are very well clustered,      a small s(i) (around 0) means that the observation lies between      two clusters, and observations with a negative s(i) are probably      placed in the wrong cluster. ct1 = cutree(fit2, h=.3) c2 = cnv_log_R rownames(c2) = paste(rownames(c2), as.numeric(ct1)) sil = silhouette(ct1, cd) plot(sil)"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"Exercises","title":"distances, nearest-neighbor graphs, clustering","text":"1: install bioDist vjcitn/csamaDist. Use code: Comment qualitative differences clusterings. 2: produce report silhouette measurement second clustering. Produce three-cluster partition hc1 obtain silhouette display.","code":"library(csamaDist) data(cnv_log_R) hc1 = hclust(dist(cnv_log_R[1:8,])) hc2 = hclust(bioDist::cor.dist(cnv_log_R[1:8,]), method=\"ward.D2\")  opar = par(no.readonly=TRUE) par(mfrow=c(1,2), mar=c(4,3,1,1)) plot(hc1, main=\"Euc, complete\") plot(hc2, main=\"1-Cor, Ward's D2\") par(opar) assn =  cutree(hc2, h=.25) plot(silhouette( assn, bioDist::cor.dist(cnv_log_R[1:8,])))"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Clustering single cell RNA-seq","title":"distances, nearest-neighbor graphs, clustering","text":"code taken verbatim bluster “diagnostics” vignette.","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Acquire Grun et al’s single cell RNA-seq dataset","title":"distances, nearest-neighbor graphs, clustering","text":"[Grun 2016] (https://www.sciencedirect.com/science/article/pii/S1934590916300947) define algorithm, StemID, infers candidate multipotent cell populations human pancreas.","code":"library(scRNAseq) sce <- GrunPancreasData() ## snapshotDate(): 2022-04-26 ## see ?scRNAseq and browseVignettes('scRNAseq') for documentation ## loading from cache ## snapshotDate(): 2022-04-26 ## see ?scRNAseq and browseVignettes('scRNAseq') for documentation ## loading from cache # Quality control to remove bad cells. library(scuttle) qcstats <- perCellQCMetrics(sce) qcfilter <- quickPerCellQC(qcstats, sub.fields=\"altexps_ERCC_percent\") ## Warning in .get_med_and_mad(metric, batch = batch, subset = subset, ## share.medians = share.medians, : missing values ignored during outlier detection sce <- sce[,!qcfilter$discard]  # Normalization by library size. sce <- logNormCounts(sce)  # Feature selection. library(scran) dec <- modelGeneVar(sce) hvgs <- getTopHVGs(dec, n=1000)  # Dimensionality reduction. set.seed(1000) library(scater) sce <- runPCA(sce, ncomponents=20, subset_row=hvgs) sce <- runTSNE(sce, subset_row=hvgs)"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Clustering using a nearest-neighbor graph; visualization via TSNE and PCA","title":"distances, nearest-neighbor graphs, clustering","text":"bluster’s makeSNNGraph help page","code":"The 'makeSNNGraph' function builds a shared nearest-neighbour    graph using observations as nodes. For each observation, its 'k'    nearest neighbours are identified using the 'findKNN' function,    based on distances between their expression profiles (Euclidean by    default). An edge is drawn between all pairs of observations that    share at least one neighbour, weighted by the characteristics of    the shared nearest neighbors - see \"Weighting Schemes\" below.     The aim is to use the SNN graph to perform clustering of    observations via community detection algorithms in the 'igraph'    package. This is faster and more memory efficient than    hierarchical clustering for large numbers of observations. In    particular, it avoids the need to construct a distance matrix for    all pairs of observations. Only the identities of nearest    neighbours are required, which can be obtained quickly with    methods in the 'BiocNeighbors' package. library(bluster) mat <- reducedDim(sce) clust.info <- clusterRows(mat, NNGraphParam(), full=TRUE) clusters <- clust.info$clusters table(clusters) ## clusters ##   1   2   3   4   5   6   7   8   9  10  11  12  ## 285 171 161  59 174  49  70 137  69  65  28  23 plot(reducedDims(sce)$TSNE, col=clusters, pch=19, main=\"TSNE\") plot(reducedDims(sce)$PCA, col=clusters, pch=19, main=\"PCA\") pairs(reducedDims(sce)$PCA[,1:4], col=clusters, pch=19, main=\"PCA\")"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Assessment via pairwiseModularity","title":"distances, nearest-neighbor graphs, clustering","text":"","code":"g <- clust.info$objects$graph ratio <- pairwiseModularity(g, clusters, as.ratio=TRUE)  cluster.gr <- igraph::graph_from_adjacency_matrix(log2(ratio+1),      mode=\"upper\", weighted=TRUE, diag=FALSE)  # Increasing the weight to increase the visibility of the lines. set.seed(1100101) plot(cluster.gr, edge.width=igraph::E(cluster.gr)$weight*5,     layout=igraph::layout_with_lgl)"},{"path":"/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Vince Carey. Author, maintainer.","code":""},{"path":"/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Carey V (2023). CSHstats: discussions exercises classical statistics CSHL 2022. R package version 0.0.33, https://github.com/vjcitn/CSHstats.","code":"@Manual{,   title = {CSHstats: discussions and exercises on classical statistics for CSHL 2022},   author = {Vince Carey},   year = {2023},   note = {R package version 0.0.33},   url = {https://github.com/vjcitn/CSHstats}, }"},{"path":"/index.html","id":"cshstats","dir":"","previous_headings":"","what":"discussions and exercises on classical statistics for CSHL 2022","title":"discussions and exercises on classical statistics for CSHL 2022","text":"R vignettes/pkgdown elementary statistics summer course DRAFT! preliminary 19 May 2022 One view conceptual scheme course three main vertices:  students start lower left vertex need move along bottom edge work high-dimensional data generated sequencing technologies. Ultimately want use data climb edges expand biological medical knowledge. ’ll conduct introductory exploration four topic areas statistics data science: Probability simulation Exploratory data analysis visualization Hypothesis testing Linear models MultiAssayExperiment applications SingleCellMultimodal (convenience) CITEseq TENx MultiOme seqFISH","code":""},{"path":"/reference/accex.html","id":null,"dir":"Reference","previous_headings":"","what":"MultiAssayExperiment instance for ACC — accex","title":"MultiAssayExperiment instance for ACC — accex","text":"MultiAssayExperiment instance ACC","code":""},{"path":"/reference/accex.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"MultiAssayExperiment instance for ACC — accex","text":"","code":"accex"},{"path":"/reference/accex.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"MultiAssayExperiment instance for ACC — 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from example(coverage) for GenomicAlignments — c5000","text":"numeric vector","code":""},{"path":"/reference/de_results.html","id":null,"dir":"Reference","previous_headings":"","what":"topTable excerpt for SRP045638, see vGene — de_results","title":"topTable excerpt for SRP045638, see vGene — de_results","text":"topTable excerpt SRP045638, see vGene","code":""},{"path":"/reference/de_results.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"topTable excerpt for SRP045638, see vGene — de_results","text":"","code":"de_results"},{"path":"/reference/de_results.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"topTable excerpt for SRP045638, see vGene — de_results","text":"data.frame","code":""},{"path":"/reference/doubsim.html","id":null,"dir":"Reference","previous_headings":"","what":"simulated draws of top card from a shuffled deck of cards — doubsim","title":"simulated draws of top card from a shuffled deck of 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cards","code":""},{"path":"/reference/faces.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"get faces of a collection of cards — faces","text":"","code":"faces(x)"},{"path":"/reference/faces.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"get faces of a collection of cards — faces","text":"x card deck made `build_deck`","code":""},{"path":"/reference/faces.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"get faces of a collection of cards — faces","text":"","code":"d = build_deck() d[1] #> [1] \"2 ♡\" faces(d[1:2]) #> [1] \"2\" \"3\""},{"path":"/reference/fos_ex.html","id":null,"dir":"Reference","previous_headings":"","what":"RNASeq2GeneNorm measures for FOS from TCGA ACC samples — fos_ex","title":"RNASeq2GeneNorm measures for FOS from TCGA ACC samples — fos_ex","text":"RNASeq2GeneNorm measures FOS TCGA ACC 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full_house","text":"x vector cards","code":""},{"path":"/reference/full_house.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"test for full house — full_house","text":"","code":"d = build_deck() h1 = c(d[1], d[14], d[27], d[2], d[15]) h1 #> [1] \"2 ♡\" \"2 ♢\" \"2 ♣\" \"3 ♡\" \"3 ♢\" full_house(h1) #> [1] TRUE h2 = c(d[1], d[14], d[27], d[2], d[16]) h2 #> [1] \"2 ♡\" \"2 ♢\" \"2 ♣\" \"3 ♡\" \"4 ♢\" full_house(h2) #> [1] FALSE"},{"path":"/reference/gtex_exc_chr20_b38.html","id":null,"dir":"Reference","previous_headings":"","what":"data.frame with GTEx lung eQTL data and metadata, a selection from chr20 — gtex_exc_chr20_b38","title":"data.frame with GTEx lung eQTL data and metadata, a selection from chr20 — gtex_exc_chr20_b38","text":"data.frame GTEx lung eQTL data metadata, selection chr20","code":""},{"path":"/reference/gtex_exc_chr20_b38.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"data.frame with 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cards","code":""},{"path":"/reference/is_flush.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"test for flush — is_flush","text":"","code":"d = build_deck() h1 = c(d[1:4], d[6]) h1 #> [1] \"2 ♡\" \"3 ♡\" \"4 ♡\" \"5 ♡\" \"7 ♡\" is_flush(h1) #> [1] TRUE"},{"path":"/reference/mod.html","id":null,"dir":"Reference","previous_headings":"","what":"model matrix for SRP045638, see vGene — mod","title":"model matrix for SRP045638, see vGene — mod","text":"model matrix SRP045638, see vGene","code":""},{"path":"/reference/mod.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"model matrix for SRP045638, see vGene — mod","text":"","code":"mod"},{"path":"/reference/mod.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"model matrix for SRP045638, see vGene — mod","text":"data.frame","code":""},{"path":"/reference/nonlindat.html","id":null,"dir":"Reference","previous_headings":"","what":"a data frame with y and x in a sigmoidal relationship (with error and a covariate z) — nonlindat","title":"a data frame with y and x in a sigmoidal relationship (with error and a covariate z) — nonlindat","text":"data frame y x sigmoidal relationship (error covariate z)","code":""},{"path":"/reference/nonlindat.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"a data frame with y and x in a sigmoidal relationship (with error and a covariate z) — nonlindat","text":"","code":"nonlindat"},{"path":"/reference/nonlindat.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"a data frame with y and x in a sigmoidal relationship (with error and a covariate z) — nonlindat","text":"data.frame","code":""},{"path":"/reference/nonlindat.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"a data frame with y and x in a sigmoidal relationship (with error and a covariate z) — nonlindat","text":"","code":"data(nonlindat) plot(y~x, data=nonlindat, col=z+1, pch=19)"},{"path":"/reference/one_pair.html","id":null,"dir":"Reference","previous_headings":"","what":"test for one pair — one_pair","title":"test for one pair — one_pair","text":"test one pair","code":""},{"path":"/reference/one_pair.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"test for one pair — one_pair","text":"","code":"one_pair(x)"},{"path":"/reference/one_pair.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"test for one pair — one_pair","text":"x vector cards","code":""},{"path":"/reference/one_pair.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"test for one pair — one_pair","text":"logical(1)","code":""},{"path":"/reference/one_pair.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"test for one pair — one_pair","text":"","code":"d = build_deck() hand_1 = c(d[1], d[14], d[2:4] ) hand_1 #> [1] \"2 ♡\" \"2 ♢\" \"3 ♡\" \"4 ♡\" \"5 ♡\" one_pair(hand_1[1]) #> [1] FALSE hand_2 = c(d[1], d[6], d[2:4] ) hand_2 #> [1] \"2 ♡\" \"7 ♡\" \"3 ♡\" \"4 ♡\" \"5 ♡\" one_pair(hand_2[2]) #> [1] FALSE"},{"path":"/reference/queryCHCA.html","id":null,"dir":"Reference","previous_headings":"","what":"use a snapshot of CuratedQueryAtlasR through duckdb — queryCHCA","title":"use a snapshot of CuratedQueryAtlasR through duckdb — queryCHCA","text":"use snapshot CuratedQueryAtlasR duckdb","code":""},{"path":"/reference/queryCHCA.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"use a snapshot of CuratedQueryAtlasR through duckdb — queryCHCA","text":"","code":"queryCHCA(con, inst = FALSE)"},{"path":"/reference/queryCHCA.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"use a snapshot of CuratedQueryAtlasR through duckdb — queryCHCA","text":"con connection duckdb::duckdb(...) inst logical(1) TRUE install httpfs duckdb","code":""},{"path":"/reference/queryCHCA.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"use a snapshot of CuratedQueryAtlasR through duckdb — queryCHCA","text":"dplyr::tbl metadata","code":""},{"path":"/reference/queryCHCA.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"use a snapshot of CuratedQueryAtlasR through duckdb — queryCHCA","text":"","code":"if (interactive()) { con = DBI::dbConnect(duckdb::duckdb()) queryCHCA(con) |> select(sample_) |> head() DBI::dbDisconnect(con) }"},{"path":"/reference/suits.html","id":null,"dir":"Reference","previous_headings":"","what":"get suits of a collection of cards — suits","title":"get suits of a collection of cards — suits","text":"get suits collection cards","code":""},{"path":"/reference/suits.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"get suits of a collection of cards — suits","text":"","code":"suits(x)"},{"path":"/reference/suits.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"get suits of a collection of cards — suits","text":"x card deck made `build_deck`","code":""},{"path":"/reference/suits.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"get suits of a collection of cards — suits","text":"","code":"d = build_deck() d[1] #> [1] \"2 ♡\" suits(d[1:2]) #> [1] \"♡\" \"♡\""},{"path":"/reference/two_pairs.html","id":null,"dir":"Reference","previous_headings":"","what":"test for two pairs — two_pairs","title":"test for two pairs — two_pairs","text":"test two pairs","code":""},{"path":"/reference/two_pairs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"test for two pairs — two_pairs","text":"","code":"two_pairs(x)"},{"path":"/reference/two_pairs.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"test for two pairs — two_pairs","text":"x vector cards","code":""},{"path":"/reference/two_pairs.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"test for two pairs — two_pairs","text":"","code":"d = build_deck() h1 = c(d[1], d[14], d[27], d[2], d[15]) h1 #> [1] \"2 ♡\" \"2 ♢\" \"2 ♣\" \"3 ♡\" \"3 ♢\" two_pairs(h1) #> [1] FALSE"},{"path":"/reference/vGene.html","id":null,"dir":"Reference","previous_headings":"","what":"vGene result for a recount dataset, SRP045638 — vGene","title":"vGene result for a recount dataset, SRP045638 — vGene","text":"vGene result recount dataset, SRP045638","code":""},{"path":"/reference/vGene.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"vGene result for a recount dataset, SRP045638 — vGene","text":"","code":"vGene"},{"path":"/reference/vGene.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"vGene result for a recount dataset, SRP045638 — vGene","text":"limma EList","code":""},{"path":"/reference/vGene.html","id":"note","dir":"Reference","previous_headings":"","what":"Note","title":"vGene result for a recount dataset, SRP045638 — vGene","text":"see https://lcolladotor.github.io/cshl_rstats_genome_scale_2023/differential-gene-expression-analysis--limma.html#differential-expression","code":""},{"path":"/reference/yy1_ex.html","id":null,"dir":"Reference","previous_headings":"","what":"RNASeq2GeneNorm measures for YY1 from TCGA ACC samples — yy1_ex","title":"RNASeq2GeneNorm measures for YY1 from TCGA ACC samples — yy1_ex","text":"RNASeq2GeneNorm measures YY1 TCGA ACC samples","code":""},{"path":"/reference/yy1_ex.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"RNASeq2GeneNorm measures for YY1 from TCGA ACC samples — yy1_ex","text":"","code":"yy1_ex"},{"path":"/reference/yy1_ex.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"RNASeq2GeneNorm measures for YY1 from TCGA ACC samples — yy1_ex","text":"numeric vector","code":""}]
+[{"path":"/articles/S1_probability.html","id":"learning-objectives","dir":"Articles","previous_headings":"","what":"Learning objectives","title":"S1_probability: Definitions and exercises","text":"understand use sample() understand use set.seed() control behavior random number generation distinguish sample size experiment replication size simulation Explain relationship precision probability estimate sample size associated experiment binomially distributed outcomes outcomes governed Poisson Negative Binomial models general Understand simulate data null (e.g., fair deck) alternative (e.g., biased deck) conditions Understand difference finite, countably infinite, uncountably infinite sample spaces Define use probability density functions cumulative distribution functions continuous outcomes joint probability distribution two random quantities contours bivariate density: empirical model-based covariance correlation","code":""},{"path":"/articles/S1_probability.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"S1_probability: Definitions and exercises","text":"concept probability “long run relative frequency”. ’ll work several models random events make concrete.","code":""},{"path":[]},{"path":[]},{"path":"/articles/S1_probability.html","id":"random-permutations-with-sample","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards","what":"Random permutations with sample()","title":"S1_probability: Definitions and exercises","text":"’ll take granted sample(x, size=length(x), replace=FALSE) R achieves goal “shuffling” elements x. Thus assume , x vector R, aspect ordering elements s1 can used predict anything ordering elements s2. words, sample(x, size, replace=FALSE) taken primitive operation permutes elements x “random” way.","code":"s1 = sample(x, size=length(x), replace=FALSE) s2 = sample(x, size=length(x), replace=FALSE) set.seed(5432) # initialize, for reproducibility, the random number generator sample(1:5, replace=FALSE) # permute (1,2,3,4,5) ## [1] 4 2 1 3 5 sample(1:5, replace=FALSE) # a new, unpredictable, permutation ## [1] 3 4 1 2 5"},{"path":"/articles/S1_probability.html","id":"exercises","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards > Random permutations with sample()","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"1: second permutation produced termed “unpredictable”? 2: Predict outcome sample(1:5, replace=FALSE), run just one shown .","code":""},{"path":"/articles/S1_probability.html","id":"card-deck-definitions-and-operations","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards","what":"Card deck definitions and operations","title":"S1_probability: Definitions and exercises","text":"card deck vector 52 elements. Unicode characters encode “suits”. already installed CSHstats (long time ago) use get access software needed computations document. fair deck one card combination “face” “suit”.","code":"BiocManager::install(\"vjcitn/CSHstats\")  # install.packages(\"BiocManager\") if necessary library(CSHstats) d = build_deck() d ##  [1] \"2 ♡\"  \"3 ♡\"  \"4 ♡\"  \"5 ♡\"  \"6 ♡\"  \"7 ♡\"  \"8 ♡\"  \"9 ♡\"  \"10 ♡\" \"J ♡\"  ## [11] \"Q ♡\"  \"K ♡\"  \"A ♡\"  \"2 ♢\"  \"3 ♢\"  \"4 ♢\"  \"5 ♢\"  \"6 ♢\"  \"7 ♢\"  \"8 ♢\"  ## [21] \"9 ♢\"  \"10 ♢\" \"J ♢\"  \"Q ♢\"  \"K ♢\"  \"A ♢\"  \"2 ♣\"  \"3 ♣\"  \"4 ♣\"  \"5 ♣\"  ## [31] \"6 ♣\"  \"7 ♣\"  \"8 ♣\"  \"9 ♣\"  \"10 ♣\" \"J ♣\"  \"Q ♣\"  \"K ♣\"  \"A ♣\"  \"2 ♤\"  ## [41] \"3 ♤\"  \"4 ♤\"  \"5 ♤\"  \"6 ♤\"  \"7 ♤\"  \"8 ♤\"  \"9 ♤\"  \"10 ♤\" \"J ♤\"  \"Q ♤\"  ## [51] \"K ♤\"  \"A ♤\" unique(suits(d)) ## [1] \"♡\" \"♢\" \"♣\" \"♤\" unique(faces(d)) ##  [1] \"2\"  \"3\"  \"4\"  \"5\"  \"6\"  \"7\"  \"8\"  \"9\"  \"10\" \"J\"  \"Q\"  \"K\"  \"A\" table(suits(d), faces(d)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1"},{"path":"/articles/S1_probability.html","id":"exercises-1","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards > Card deck definitions and operations","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"3: Write code produces new deck fair except two copies ten hearts. Verify new deck property.","code":""},{"path":"/articles/S1_probability.html","id":"shuffling-the-deck","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards","what":"Shuffling the deck","title":"S1_probability: Definitions and exercises","text":"reproducible shuffling event can programmed follows:","code":"set.seed(1234)  # any numeric seed will do but you need to record it shuffle_deck = function(d) sample(d, size=length(d), replace=FALSE) head(d)         # top 6 cards ## [1] \"2 ♡\" \"3 ♡\" \"4 ♡\" \"5 ♡\" \"6 ♡\" \"7 ♡\" head(shuffle_deck(d)) ## [1] \"3 ♣\"  \"4 ♢\"  \"10 ♢\" \"Q ♣\"  \"6 ♤\"  \"9 ♤\""},{"path":"/articles/S1_probability.html","id":"the-top-card-after-a-shuffle","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards","what":"The top card after a shuffle","title":"S1_probability: Definitions and exercises","text":"","code":"set.seed(4141) top_draw = function(d) shuffle_deck(d)[1] top_draw(d) ## [1] \"A ♤\" top_draw(d) ## [1] \"5 ♤\""},{"path":"/articles/S1_probability.html","id":"exercises-2","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Simulating shuffled playing cards > The top card after a shuffle","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"4: top card next shuffle? 5: Write code get third card. 6: probability top draw shuffled fair deck heart?","code":""},{"path":[]},{"path":"/articles/S1_probability.html","id":"a-simulation-process-repeated-shuffles-and-draws","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Estimating the probability of an event","what":"A simulation process: repeated shuffles and draws","title":"S1_probability: Definitions and exercises","text":"’s simple way estimating probability top draw shuffled fair deck heart, construed long run frequency. ’ll simulate 100 shuffles save results testing suit top card. concise approach R :","code":"heart_sign = function() \"\\U2661\"  # unicode U2661, prepend backslash heart_sign() ## [1] \"♡\" res = rep(NA, 100) for (i in 1:100) {  res[i] = (suits(top_draw(d)) == heart_sign()) # TRUE if top card is a heart } head(res) ## [1] FALSE FALSE  TRUE  TRUE  TRUE FALSE ### relative frequency of the event \"suit of top card is 'heart'\" sum(res)/length(res) ## [1] 0.36 mean(replicate( 100, suits(top_draw(d)) == heart_sign()) ) ## [1] 0.22"},{"path":"/articles/S1_probability.html","id":"exercises-3","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Estimating the probability of an event > A simulation process: repeated shuffles and draws","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"7: interpret difference two probability estimates given ?","code":""},{"path":"/articles/S1_probability.html","id":"replicating-the-estimation-process","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Estimating the probability of an event","what":"Replicating the estimation process","title":"S1_probability: Definitions and exercises","text":"Let’s intensify investigation aim understanding uncertainty estimation. ’ll define variable gives size “experiment”: shuffling 100 times ’ll refer sample size, SSIZE study estimation procedure replicating experiment N_REPLICATION times.","code":"SSIZE = 100 N_REPLICATION = 500 set.seed(10101) # initialize, for reproducibility, the random number generator doubsim = replicate(N_REPLICATION,      mean(replicate( SSIZE, suits(top_draw(d)) == heart_sign()) )     ) hist(doubsim, xlim=c(0,1))"},{"path":"/articles/S1_probability.html","id":"exercises-4","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Estimating the probability of an event > Replicating the estimation process","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"8: can make estimate probability event “suit top card ‘heart’” precise? Answer: increase SSIZE.  increased “sample size”, reduced variation experiment--experiment estimates probability heart suit top card.","code":"SSIZE = 500 set.seed(101012) doubsim2 = replicate(N_REPLICATION,      mean(replicate( SSIZE, suits(top_draw(d)) == heart_sign()) )     ) hist(doubsim2, xlim=c(0,1))"},{"path":"/articles/S1_probability.html","id":"formal-probability-models","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event","what":"Formal probability models","title":"S1_probability: Definitions and exercises","text":"Intuitively, probability drawing heart well-shuffled fair deck 1/4. repeat shuffling drawing one hundred times, expect around 25 draws reveal heart. Formal probability models enable us reason systematically mean around description expectation. models can also create accurate predictions likely outcomes complex events. useful define sample space probability model, set possible outcomes random process modeled. top-card-drawn example, sample space set suits, disregard face value. fair deck, point sample space probability \\(1/4\\). Events interest “top card heart” “top card heart”. probabilities events derivable probabilities constituent outcomes.","code":""},{"path":"/articles/S1_probability.html","id":"using-the-binomial-probability-model","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Formal probability models","what":"Using the binomial probability model","title":"S1_probability: Definitions and exercises","text":"series independent dichotomous events (true false, zero one, heart non-heart) can modeled using probability mass function binomial distribution. two parameters, \\(p\\) \\(n\\), \\(p\\) (unobservable) probability event (say “suit top card ‘heart’”) \\(n\\) number independent trials random dichotomy observed. \\(n\\) “trials”, event probability \\(p\\), probability seeing event \\(x\\) times \\[ Pr(X = x; n, p) = {\\binom{n}{x}} p^x(1-p)^{n-x} \\] written \\(X\\) denote random quantity \\(x\\) denote realization. single draw, \\(X\\) count hearts seen draw, \\[ Pr(X=0; 1, 1/4) = 1-1/4 = 3/4 \\] \\[ Pr(X=1; 1, 1/4) = 1/4 \\]","code":""},{"path":"/articles/S1_probability.html","id":"exercises-5","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Formal probability models > Using the binomial probability model","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"9: Modify production doubsim2 \\(x\\)-axis histogram units “number times top card heart”.","code":"hist(doubsim3, xlim=c(.15*500,.35*500), xlab=\"count of draws with heart as suit of top card\")"},{"path":"/articles/S1_probability.html","id":"visualizing-the-model-and-the-data","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Formal probability models","what":"Visualizing the model and the data","title":"S1_probability: Definitions and exercises","text":"formula given tells us frequently observe given count. R function dbinom can compute probability, multiply number realizations get height histogram.  Notice histogram, virtue binning counts, seem reflect shape theoretical frequency function given dots. can remedied increasing number replicates used. considerable research regarding design histogram displays. See ?nclass.Sturges references. One unpleasant feature display doubsim2 seems imply asymmetric distribution. Another way “cuts ” extremes.","code":"hist(doubsim3, xlim=c(.15*500,.35*500),     xlab=\"count of draws with heart as suit of top card\", ylim=c(0,115)) points(80:160, 2500*dbinom(80:160, 500, 13/52), pch=19, cex=.5) legend(78, 110, pch=19, legend=\"scaled dbinom(x, 500, .25)\", bty=\"n\", cex=.85)"},{"path":"/articles/S1_probability.html","id":"exercises-6","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > Formal probability models > Visualizing the model and the data","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"10: Write couple sentences carefully distinguishing displays doubsim2 doubsim3 . Explain choice heuristic name “doubsim”.","code":""},{"path":"/articles/S1_probability.html","id":"a-biased-deck","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event","what":"A biased deck","title":"S1_probability: Definitions and exercises","text":"Recall layout fair deck: make copy one card remove one:","code":"table(suits(d), faces(d)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 bd = d bd[18] = bd[3] table(suits(bd), faces(bd)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 2 1 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 0 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1"},{"path":"/articles/S1_probability.html","id":"exercises-7","dir":"Articles","previous_headings":"The probability of a 0-1 (binary or dichotomous) event > A biased deck","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"11: probability top card drawn shuffle bd heart? 12: probability top card drawn shuffle bd club?","code":""},{"path":"/articles/S1_probability.html","id":"probability-models-for-categorical-outcomes","dir":"Articles","previous_headings":"","what":"Probability models for categorical outcomes","title":"S1_probability: Definitions and exercises","text":"Thus far focused dichotomy: top draw heart . can consider possible suits 4-valued response.","code":""},{"path":"/articles/S1_probability.html","id":"a-contingency-table","dir":"Articles","previous_headings":"Probability models for categorical outcomes","what":"A contingency table","title":"S1_probability: Definitions and exercises","text":"Let’s simulate process drawing top card shuffling, tabulate suits observed.","code":"set.seed(4321) table( tops <- replicate(500, suits(top_draw(bd))) ) ##  ##   ♡   ♢   ♣   ♤  ## 148 106 126 120"},{"path":"/articles/S1_probability.html","id":"exercises-8","dir":"Articles","previous_headings":"Probability models for categorical outcomes > A contingency table","what":"Exercises","title":"S1_probability: Definitions and exercises","text":"13: expect counts suits table deck fair?","code":""},{"path":"/articles/S1_probability.html","id":"multinomial-model-and-simulation","dir":"Articles","previous_headings":"Probability models for categorical outcomes","what":"Multinomial model and simulation","title":"S1_probability: Definitions and exercises","text":"adopted binomial model number top draws suit “heart” fixed number shuffles: \\[ Pr(X = x; n, p) = {\\binom{n}{x}} p^x(1-p)^{n-x} \\] fair deck, \\(p= 1/4\\). generalization vector responses multinomial model. can use (ordered) vector counts top draws yielding different suits. problem parameters \\(N\\) (number trials), \\(k\\) (number categories), \\(p_1, \\ldots, p_k\\), category-specific probabilities. realizations denoted \\(x_1, \\ldots, x_k\\) \\(\\sum_i x_i = N\\). Now probability model defined terms random vectors vectors probabilities: \\[ Pr(X_1 = x_1, \\ldots, X_k = x_k) = \\frac{n!}{x_1! \\cdots x_k!} p_1^{x_1} \\cdots p_k^{x_k} \\] provides elegant way producing frequency distributions suit top draw. introduce pseudorandom number generation multinomial model, using rmultinom. Notice use deck d producing matrix counts. Previously applied sample() 52-vector cards. Now use model develop data interest.","code":"NREP = 10000 SSIZE = 500 mnmat = rmultinom(NREP, SSIZE, rep(.25,4)) rownames(mnmat) = c(\"\\U2661\", \"\\U2662\", \"\\U2663\", \"\\U2664\") mnmat[,1]  # one draw ##   ♡   ♢   ♣   ♤  ## 131 125 110 134 apply(mnmat,1,mean) ##        ♡        ♢        ♣        ♤  ## 124.9621 124.9080 125.0362 125.0937"},{"path":"/articles/S1_probability.html","id":"exercise","dir":"Articles","previous_headings":"Probability models for categorical outcomes > Multinomial model and simulation","what":"Exercise","title":"S1_probability: Definitions and exercises","text":"14: Modify call rmultinom obtain distributions top card suits biased deck bd. Hint: Change part call involving rep().","code":""},{"path":[]},{"path":"/articles/S1_probability.html","id":"modeling-collections-of-counts","dir":"Articles","previous_headings":"Probability models for categorical outcomes > The Poisson distribution","what":"Modeling collections of counts","title":"S1_probability: Definitions and exercises","text":"Outcomes taking form integer counts arise many appications. example, quarry floor divided squares one meter side. 30 squares searched fossil number specimens per square recorded. square 5 specimens. (Example Probability Models Applications, . Olkin, L. Gleser, C. Derman, ch 6.3.) table includes nspec, number specimens square, freq, number squares corresponding number specimens, pred, predicted number specimens based Poisson model mean parameter 0.73 specimens per square. derive quantities pred, used dpois counts per square, mean parameter set 0.73. derive , use obtain average number fossils per square. Poisson model mean \\(\\lambda\\) \\[ Pr(X = k; \\lambda) = \\frac{e^{-\\lambda}\\lambda^k}{k!} \\]","code":"foss = data.frame(nspec=0:4, freq=c(16,9,3,1,1), pred=round(30*dpois(0:4, 0.73), 2)) foss ##   nspec freq  pred ## 1     0   16 14.46 ## 2     1    9 10.55 ## 3     2    3  3.85 ## 4     3    1  0.94 ## 5     4    1  0.17 sum(foss$nspec * foss$freq)/30 ## [1] 0.7333333"},{"path":"/articles/S1_probability.html","id":"exercise-1","dir":"Articles","previous_headings":"Probability models for categorical outcomes > The Poisson distribution","what":"Exercise","title":"S1_probability: Definitions and exercises","text":"15: Use formula explain prediction 14.46 squares zero fossils.","code":""},{"path":"/articles/S1_probability.html","id":"a-countably-infinite-sample-space","dir":"Articles","previous_headings":"Probability models for categorical outcomes > The Poisson distribution","what":"A countably infinite sample space","title":"S1_probability: Definitions and exercises","text":"binomial multinomial models discussed finite discrete sample spaces. sample space Poisson model set non-negative integers. mass function arises fact \\(e^\\lambda = \\sum \\lambda^k/k!\\), sum taken non-negative integers.","code":""},{"path":"/articles/S1_probability.html","id":"the-negative-binomial-model","dir":"Articles","previous_headings":"Probability models for categorical outcomes","what":"The negative binomial model","title":"S1_probability: Definitions and exercises","text":"mass function \\[ p(x; \\theta, \\mu) = \\frac{\\Gamma(\\theta + x)}{\\Gamma(\\theta)y!}     \\frac{\\mu^y \\theta^\\theta}{(\\mu + \\theta)^{\\theta + y}} \\] useful later material.","code":""},{"path":"/articles/S1_probability.html","id":"mean-variance","dir":"Articles","previous_headings":"Probability models for categorical outcomes","what":"Mean, variance","title":"S1_probability: Definitions and exercises","text":"sample mean vector \\(x = (x_1, \\ldots, x_n)\\) defined \\(\\bar{x} = n^{-1}\\sum_i x_i\\). (unbiased estimator ) sample variance \\((n-1)^{-1}\\sum_i (x_i - \\bar{x})^2\\). sometimes refer mean variance context probability models rather samples. mean continuous distribution defined discrete distribution probability mass function \\(p\\) mean \\[ E(x) = \\sum x p(x), \\] sum taken sample space associated model. Writing \\(\\mu\\) mean value distribution study, variance discrete distribution \\[ V(x) = \\sum (x-\\mu)^2 p(x) dx. \\]","code":""},{"path":"/articles/S1_probability.html","id":"models-for-continuous-outcomes","dir":"Articles","previous_headings":"","what":"Models for continuous outcomes","title":"S1_probability: Definitions and exercises","text":"models ’ve considered thus far discrete responses – sample space either finite countably infinite. continuous responses, sample space uncountably infinite. sample space may interval real line, whole real line. discuss define probabilities subsets sample space.","code":""},{"path":"/articles/S1_probability.html","id":"univariate-response","dir":"Articles","previous_headings":"Models for continuous outcomes","what":"Univariate response","title":"S1_probability: Definitions and exercises","text":"concreteness, use RNA-seq data derived Cancer Genome Atlas. ’ll focus 79 values normalized RSEM-based estimates expression YY1 adrenocortical carcinoma. refer vector “real valued” outcomes.","code":"data(yy1_ex) head(yy1_ex) ## TCGA-OR-A5J1-01A-11R-A29S-07 TCGA-OR-A5J2-01A-11R-A29S-07  ##                    1455.8117                    1688.6318  ## TCGA-OR-A5J3-01A-11R-A29S-07 TCGA-OR-A5J5-01A-11R-A29S-07  ##                    1821.3598                    1877.6143  ## TCGA-OR-A5J6-01A-31R-A29S-07 TCGA-OR-A5J7-01A-11R-A29S-07  ##                     634.3023                    1132.3706"},{"path":"/articles/S1_probability.html","id":"cumulative-distribution-function-quantiles","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response","what":"Cumulative distribution function; quantiles","title":"S1_probability: Definitions and exercises","text":"’ll use capital letters denote random variables. formal definition “random variable” given textbooks; use term informally refer quantities regard random. function \\(F(x) = \\mbox{Pr}(X < x)\\) called cumulative distribution function (CDF) random variable \\(X\\). YY1 measures, can produce visualization associated CDF:  quantiles distribution given inverse CDF. quantile function takes number \\(p\\) 0 1 returns number \\(F^{-1}(p)\\). graph shows 0.80 quantile distribution YY1 vector 1584.","code":"plot(ecdf(yy1_ex)) abline(h=.8, lty=2) arrows(1583, .8, 1583, 0, lty=2)"},{"path":"/articles/S1_probability.html","id":"exercise-2","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response","what":"Exercise","title":"S1_probability: Definitions and exercises","text":"16: Show proportion YY1 observations exceeding 1584 approximately 20%.","code":""},{"path":"/articles/S1_probability.html","id":"histogram-probability-density-function","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response","what":"Histogram, probability density function","title":"S1_probability: Definitions and exercises","text":"histogram tunable display relative frequencies values vector.  probability density function continuous random variable \\(X\\) satisfies \\[ \\int_a^b f(x) dx = \\mbox{Pr}(< X < b) \\] can estimate density function sample various ways. simple illustration:  interest use approxfun numerical integration density estimate given , estimate probability YY1 expression lies given interval. acceptable? changing bandwidth density estimator produce better results? potential overfitting problem?","code":"par(mfrow=c(2,1), mar=c(4,3,1,1)) hist(yy1_ex, xlim=c(400, 2600)) hist(yy1_ex, breaks=20, xlim=c(400, 2600)) plot(dd <- density(yy1_ex)) dfun = approxfun(dd$x, dd$y) integrate(dfun, 1000, 1500)  # density-based ## 0.481747 with absolute error < 1e-05 mean(yy1_ex >=1000 & yy1_ex <= 1500) # empirical ## [1] 0.5316456"},{"path":"/articles/S1_probability.html","id":"some-widely-used-models-for-continuous-responses","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response","what":"Some widely used models for continuous responses","title":"S1_probability: Definitions and exercises","text":"’ll use simulation illustrate shapes various distributions. R makes simple family functions whose names begin r.","code":""},{"path":"/articles/S1_probability.html","id":"uniform-distribution-on-01","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response > Some widely used models for continuous responses","what":"Uniform distribution on [0,1]","title":"S1_probability: Definitions and exercises","text":"density function \\(f(x) = 1\\) \\(x \\[0,1]\\) 0 otherwise.","code":"hist(runif(10000, 0, 1), prob=TRUE)"},{"path":"/articles/S1_probability.html","id":"exercise-3","dir":"Articles","previous_headings":"","what":"S1_probability: Definitions and exercises","title":"S1_probability: Definitions and exercises","text":"17: Use code like obtain value density random variable uniform density interval [0, 2].","code":""},{"path":"/articles/S1_probability.html","id":"gaussian-model","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response > Some widely used models for continuous responses","what":"Gaussian model","title":"S1_probability: Definitions and exercises","text":"Gaussian distribution also called “normal”. shape position real line determined mean variance. Symbolically, model often written \\(N(\\mu, \\sigma^2)\\), density function \\(f(x) = 1/\\sqrt{2\\pi \\sigma^2} \\exp\\{(x-\\mu)^2/2 \\sigma^2\\}\\).","code":"hist(rnorm(10000, 0, 1), prob=TRUE) lines(seq(-4,4,len=100), dnorm(seq(-4,4,len=100)))"},{"path":"/articles/S1_probability.html","id":"exponential-and-gamma-models-for-survival-data","dir":"Articles","previous_headings":"Models for continuous outcomes > Univariate response > Some widely used models for continuous responses","what":"Exponential and Gamma models for survival data","title":"S1_probability: Definitions and exercises","text":"exponential model (confused exponential family models) defined random variables positive values. example survival times. ’ll use dataset survival package illustrate.  density function exponential model \\(f(x) = \\lambda e ^ {-\\lambda x}\\). formulation, \\(\\lambda\\) referred rate parameter. mean distribution \\(1/\\lambda\\).","code":"library(survival) # use myeloma records from Mayo clinic, remove censored times md = myeloma$futime[myeloma$death==1 & myeloma$entry == 0] hist(md, breaks=20, prob=TRUE, ylim=c(0,.001)) mean(md) ## [1] 1044.768 ss = seq(0,8000,.1) lines(ss, dexp(ss, rate=1/mean(md)))"},{"path":"/articles/S1_probability.html","id":"exercise-4","dir":"Articles","previous_headings":"","what":"S1_probability: Definitions and exercises","title":"S1_probability: Definitions and exercises","text":"18: close median exponential model rate 1/1045 sample median myeloma survival times? relate interpretation plot ?","code":""},{"path":"/articles/S1_probability.html","id":"mean-and-variance-for-continuous-models","dir":"Articles","previous_headings":"Models for continuous outcomes","what":"Mean and variance for continuous models","title":"S1_probability: Definitions and exercises","text":"continuous distributions, mean value \\[ E(x) = \\int x f(x) dx. \\] Writing \\(\\mu\\) mean value distribution study, variance continuous distribution \\[ V(x) = \\int (x-\\mu)^2 f(x) dx. \\]","code":""},{"path":"/articles/S1_probability.html","id":"multivariate-response","dir":"Articles","previous_headings":"Models for continuous outcomes","what":"Multivariate response","title":"S1_probability: Definitions and exercises","text":"’ve seen use univariate probability models many facets. concept joint distribution multiple random quantities central reasoning interactions among components complicated processes. following example, obtained normalized expression measures EGR1 FOS adrenocortical carcinoma tumors studied TCGA. ’ll use built-bivariate density estimation show relationship expression two transcription factors ACC.","code":"data(fos_ex) data(egr1_ex) bivdf = data.frame(fos_ex, egr1_ex) library(ggplot2) ggplot(bivdf, aes(x=log(fos_ex), y=log(egr1_ex))) + geom_point() + geom_density_2d()"},{"path":"/articles/S1_probability.html","id":"joint-cumulative-distribution-function","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Joint cumulative distribution function","title":"S1_probability: Definitions and exercises","text":"’ll focus case continuous bivariate response denoted \\((X,Y)\\). joint cumulative distribution function (cdf) \\[ F(x,y) = Pr(X < x, Y < y) \\] , log FOS log EGR1, can evaluate \\(F(7,7)\\) follows: call empirical estimate \\(F(7,7)\\).","code":"mean(log(fos_ex)<7 & log(egr1_ex)<7) ## [1] 0.278481"},{"path":"/articles/S1_probability.html","id":"covariance-matrix-bivariate-case","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Covariance matrix, bivariate case","title":"S1_probability: Definitions and exercises","text":"covariance two random variables \\(Cov(X,Y) = EXY - (EX)(EY)\\); covariance matrix symmetric, variances diagonal, covariance diagonal.","code":"var(log(fos_ex)) # univariate ## [1] 1.194019 covmat = var(cbind(log(fos_ex), log(egr1_ex))) # matrix covmat ##           [,1]      [,2] ## [1,] 1.1940188 0.9746936 ## [2,] 0.9746936 1.4137188"},{"path":"/articles/S1_probability.html","id":"using-the-bivariate-normal-model","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Using the bivariate normal model","title":"S1_probability: Definitions and exercises","text":"Given estimates bivariate mean covariance, can use multivariate normal cumulative density function produce contours distribution elliptical shapes, opposed wiggly contours saw .  estimate \\(F(7,7)\\) using model ’ll call model-based estimate \\(F(7,7)\\).","code":"bmean = c(mean(log(fos_ex)), mean(log(egr1_ex))) library(mvtnorm) xgrid = seq(3,10,.05) ygrid = seq(3,10,.05) ngrid = length(xgrid) nd = matrix(NA, ngrid, ngrid) for (i in 1:ngrid) {  # inefficient!  for (j in 1:ngrid) {   nd[i,j] = dmvnorm(c(xgrid[i],ygrid[j]), bmean, covmat)   }  } contour(xgrid, ygrid, nd, ylab=\"log EGR1\", xlab=\"log FOS\") points(log(fos_ex), log(egr1_ex), col=\"gray\", pch=19) pmvnorm(upper=c(7,7), mean=bmean, sigma=covmat) ## [1] 0.3368775 ## attr(,\"error\") ## [1] 1e-15 ## attr(,\"msg\") ## [1] \"Normal Completion\""},{"path":"/articles/S1_probability.html","id":"exercise-5","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response > Using the bivariate normal model","what":"Exercise","title":"S1_probability: Definitions and exercises","text":"19: Obtain empirical model-based estimates \\(F(6,5)\\) (log FOS, log EGR1).","code":""},{"path":"/articles/S1_probability.html","id":"probabilistic-independence-and-dependence","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Probabilistic independence and dependence","title":"S1_probability: Definitions and exercises","text":"“tilted contour ellipses” shown just indicate knowledge value log FOS tells us variation values log EGR1. log FOS 6, value log EGR1 much likely around 6 around 9. use concept conditional distribution address concept, denote conditional distribution function \\(F(x|y)\\), vertical bar denoting conditioning. Specifically, \\(F(x|Y=y)\\) = Pr(\\(X<x\\)) given \\(Y = y\\). Probabilistic independence two random quantities can formulated condition \\(F(x|y) = F(x)\\): knowledge value \\(Y\\) provides information distribution \\(X\\).","code":""},{"path":"/articles/S1_probability.html","id":"measures-of-correlation","dir":"Articles","previous_headings":"Models for continuous outcomes > Multivariate response","what":"Measures of correlation","title":"S1_probability: Definitions and exercises","text":"correlation coefficient two random quantities ratio covariance square root product variances. 20: Use elements covmat computed produce estimate correlation log FOS log EGR1, compare cor() R (log FOS, log EGR1).","code":""},{"path":"/articles/S1b_hyper.html","id":"the-null-situation","dir":"Articles","previous_headings":"","what":"The “null” situation","title":"S1a: A look at the hypergeometric distribution","text":"two variables independent. Let’s think x “exposure” indicator, y “outcome”. 2x2 table relating exposure outcome : Notice marginal frequencies (column row proportions 0 1) similar x y. arises construction, two variables simulated separately. Exercise: interpretation numbers 0.389 0.393 table? test independence x y produced R.. Fisher. Exercise: interpretation p-value?","code":"set.seed(234) x = rbinom(100,1,.3) y = rbinom(100,1,.4) library(gmodels) CrossTable(x,y) ##  ##   ##    Cell Contents ## |-------------------------| ## |                       N | ## | Chi-square contribution | ## |           N / Row Total | ## |           N / Col Total | ## |         N / Table Total | ## |-------------------------| ##  ##   ## Total Observations in Table:  100  ##  ##   ##              | y  ##            x |         0 |         1 | Row Total |  ## -------------|-----------|-----------|-----------| ##            0 |        44 |        28 |        72 |  ##              |     0.000 |     0.000 |           |  ##              |     0.611 |     0.389 |     0.720 |  ##              |     0.721 |     0.718 |           |  ##              |     0.440 |     0.280 |           |  ## -------------|-----------|-----------|-----------| ##            1 |        17 |        11 |        28 |  ##              |     0.000 |     0.001 |           |  ##              |     0.607 |     0.393 |     0.280 |  ##              |     0.279 |     0.282 |           |  ##              |     0.170 |     0.110 |           |  ## -------------|-----------|-----------|-----------| ## Column Total |        61 |        39 |       100 |  ##              |     0.610 |     0.390 |           |  ## -------------|-----------|-----------|-----------| ##  ## fisher.test(table(x,y)) ##  ##  Fisher's Exact Test for Count Data ##  ## data:  table(x, y) ## p-value = 1 ## alternative hypothesis: true odds ratio is not equal to 1 ## 95 percent confidence interval: ##  0.3716153 2.7041308 ## sample estimates: ## odds ratio  ##   1.016643"},{"path":"/articles/S1b_hyper.html","id":"how-to-produce-correlated-binomial-responses","dir":"Articles","previous_headings":"","what":"How to produce “correlated binomial” responses?","title":"S1a: A look at the hypergeometric distribution","text":"simple way producing dependent binary responses via logistic regression relationship. produce x, can random deterministic, let probability y=1 depend value x. R’s vectorized computations make simple. Now cross-tab Fisher’s test Exercise: interpretation numbers 0.56 0.812 table? interpretation Fisher’s test p-value? features simulation changed make p-value smaller? Note: odds ratio reported Fisher test recovered (discrepancy owing rounding):","code":"x = rbinom(100,1,.3) y = rbinom(100,1, plogis(.2+x)) # summary(glm(y~x, fam=binomial)) CrossTable(x,y) ##  ##   ##    Cell Contents ## |-------------------------| ## |                       N | ## | Chi-square contribution | ## |           N / Row Total | ## |           N / Col Total | ## |         N / Table Total | ## |-------------------------| ##  ##   ## Total Observations in Table:  100  ##  ##   ##              | y  ##            x |         0 |         1 | Row Total |  ## -------------|-----------|-----------|-----------| ##            0 |        37 |        47 |        84 |  ##              |     0.344 |     0.229 |           |  ##              |     0.440 |     0.560 |     0.840 |  ##              |     0.925 |     0.783 |           |  ##              |     0.370 |     0.470 |           |  ## -------------|-----------|-----------|-----------| ##            1 |         3 |        13 |        16 |  ##              |     1.806 |     1.204 |           |  ##              |     0.188 |     0.812 |     0.160 |  ##              |     0.075 |     0.217 |           |  ##              |     0.030 |     0.130 |           |  ## -------------|-----------|-----------|-----------| ## Column Total |        40 |        60 |       100 |  ##              |     0.400 |     0.600 |           |  ## -------------|-----------|-----------|-----------| ##  ## fisher.test(table(x,y)) ##  ##  Fisher's Exact Test for Count Data ##  ## data:  table(x, y) ## p-value = 0.09295 ## alternative hypothesis: true odds ratio is not equal to 1 ## 95 percent confidence interval: ##   0.8399315 19.8105854 ## sample estimates: ## odds ratio  ##   3.374506 (.812/(1-.812))/(.56/(1-.56)) ## [1] 3.393617"},{"path":"/articles/S1b_hyper.html","id":"connection-to-the-hypergeometric-distribution","dir":"Articles","previous_headings":"","what":"Connection to the hypergeometric distribution","title":"S1a: A look at the hypergeometric distribution","text":"’ll start simple problem. urn contains 10 balls, red, blue. pick three balls without replacement note color. table shows two balls red, one blue. hypergeometric distribution used model situation, draw nn balls urn holding NN balls yields rr balls given condition. table, probability draw given (52)⋅(51)(103)\\frac{{5 \\choose 2} \\cdot {5 \\choose 1}}{10 \\choose 3}. case, Fisher’s test indicates association color presence draw. can use 1-sided test: Use hypergeometric probability function produce p-value: Note proportions preserved frequencies multiplied 10, different two-sided p-value, similar odds ratio. Exercise: reformulation analysis larger 2x2 table : Show log cross product ratio elements ta2 given coefficient ‘red’ binomial model .","code":"color = rep(c(\"red\", \"blue\"), each=5) picked = c(1,1,0,0,0,1,0,0,0,0) ta = table(color,picked) ta ##       picked ## color  0 1 ##   blue 4 1 ##   red  3 2 fisher.test(ta) ##  ##  Fisher's Exact Test for Count Data ##  ## data:  ta ## p-value = 1 ## alternative hypothesis: true odds ratio is not equal to 1 ## 95 percent confidence interval: ##    0.0847468 195.6529809 ## sample estimates: ## odds ratio  ##   2.414224 fisher.test(ta, alt=\"less\") ##  ##  Fisher's Exact Test for Count Data ##  ## data:  ta ## p-value = 0.9167 ## alternative hypothesis: true odds ratio is less than 1 ## 95 percent confidence interval: ##   0.00000 95.99192 ## sample estimates: ## odds ratio  ##   2.414224 sum(dhyper(0:2,5,5,3)) ## [1] 0.9166667 ta2 = 10*ta fisher.test(ta2) ##  ##  Fisher's Exact Test for Count Data ##  ## data:  ta2 ## p-value = 0.04858 ## alternative hypothesis: true odds ratio is not equal to 1 ## 95 percent confidence interval: ##  1.005329 7.317139 ## sample estimates: ## odds ratio  ##   2.640147 g = glm(formula = ta2[, 2:1] ~ factor(rownames(ta2)), family = binomial) summary(g) ##  ## Call: ## glm(formula = ta2[, 2:1] ~ factor(rownames(ta2)), family = binomial) ##  ## Coefficients: ##                          Estimate Std. Error z value Pr(>|z|)     ## (Intercept)               -1.3863     0.3536  -3.921 8.82e-05 *** ## factor(rownames(ta2))red   0.9808     0.4564   2.149   0.0316 *   ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## (Dispersion parameter for binomial family taken to be 1) ##  ##     Null deviance: 4.8315e+00  on 1  degrees of freedom ## Residual deviance: 1.5543e-14  on 0  degrees of freedom ## AIC: 12.268 ##  ## Number of Fisher Scoring iterations: 3"},{"path":"/articles/S2_EDA.html","id":"eda-exploratory-data-analysis","dir":"Articles","previous_headings":"","what":"EDA: Exploratory data analysis","title":"S2_EDA: Exploratory data analysis and visualization","text":"field EDA changed, thanks advances computational visualization technology. Classical EDA addressed Assessing distributional shape Comparing batches numbers: Boxplots beyond Transformations; handling “outliers” recently, can consider exploratory data activities use interactive tables interactive graphics purpose-built graphical user interfaces explore concerns. principles include high volumes involved, sampling dimension reduction relevant every facet data accessible exploration summarization","code":""},{"path":"/articles/S2_EDA.html","id":"learning-objectives","dir":"Articles","previous_headings":"","what":"Learning objectives","title":"S2_EDA: Exploratory data analysis and visualization","text":"simple statistics may fail disclose structure visualization always conducted understand might use shiny explore tunable data visualization Box-Cox transformation family provides clues choosing transformation look qqnorm, qqplot allows general comparisons Shiny + TnT allow exploration data context linear genome annotation","code":""},{"path":"/articles/S2_EDA.html","id":"anscombes-quartet-statistics-that-miss-the-point","dir":"Articles","previous_headings":"","what":"Anscombe’s quartet: statistics that miss the point","title":"S2_EDA: Exploratory data analysis and visualization","text":"1973 Francis Anscombe constructed four bivariate datasets. four datasets interest pairs columns (x1, y1), (x2, y2), …. discussion probability provided definitions mean, variance, covariance, correlation. quick check means variables quartet. use apply function general arguments X array-like entity, MARGIN defines dimension along FUN computed additional arguments possibly provided .... MARGIN 1, FUN computed “row”, MARGIN 2, FUN computed “column”. also introduce helper function rounded_stat rounds result univariate statistic. code demonstrates x y variables identical means standard deviations. Nevertheless, variables plotted one another, :","code":"library(DT) data(anscombe) datatable(anscombe) apply(X, MARGIN, FUN, ..., simplify=TRUE) rounded_stat = function(x, stat=mean, ndig=2) round(stat(x), ndig) apply(anscombe, 2, rounded_stat, stat=mean) ##  x1  x2  x3  x4  y1  y2  y3  y4  ## 9.0 9.0 9.0 9.0 7.5 7.5 7.5 7.5 apply(anscombe, 2, rounded_stat, stat=sd) ##   x1   x2   x3   x4   y1   y2   y3   y4  ## 3.32 3.32 3.32 3.32 2.03 2.03 2.03 2.03"},{"path":"/articles/S2_EDA.html","id":"exercises","dir":"Articles","previous_headings":"Anscombe’s quartet: statistics that miss the point","what":"Exercises","title":"S2_EDA: Exploratory data analysis and visualization","text":"1. Show four correlation coefficients (x1, y1), …, (x4, y4) identical (rounding). 2. blog post addresses tidyverse approach handling data. Read blog post try get comfortable various steps towards producing using “tidy” representation.","code":"# use BiocManager::install(\"tidyverse\") if necessary library(tidyverse) tidy_anscombe <- anscombe %>%  pivot_longer(cols = everything(),               names_to = c(\".value\", \"set\"),               names_pattern = \"(.)(.)\") library(ggplot2) ggplot(tidy_anscombe,        aes(x = x,            y = y)) +   geom_point() +    facet_wrap(~set) +   geom_smooth(method = \"lm\", se = FALSE) ## `geom_smooth()` using formula = 'y ~ x'"},{"path":[]},{"path":"/articles/S2_EDA.html","id":"univariate","dir":"Articles","previous_headings":"Exploring distributional shape","what":"Univariate","title":"S2_EDA: Exploratory data analysis and visualization","text":"mode distribution “common value”. peak histogram correspond mode corresponding distribution discrete random variable. continuous random variables, mode given peak density function. basic question univariate dataset : multimodal distribution? Live Exercise: programming interactive exploration. Use R studio’s File control produce new “Shiny app”, give name “modality”. use “Run app” control. slider controls number bins used summarize values times geyser eruption. many modes might underlying distribution ?","code":""},{"path":"/articles/S2_EDA.html","id":"transformation","dir":"Articles","previous_headings":"Exploring distributional shape","what":"Transformation","title":"S2_EDA: Exploratory data analysis and visualization","text":"search transformation best symmetrizes skewed distribution, boxcox function MASS library can used. origins procedure reported Royal Statistical Society 1964. JRSS paper basic idea can construct series functional transformations random variable produce distribution (transformed scale) approximately normal. Box-Cox family transformations indexed single parameter, \\(\\lambda\\). transformation variable \\(y\\) \\(y^*(\\lambda) = \\lambda^{-1}(y^\\lambda-1)\\) (\\(\\lambda \\neq 0\\)) log \\(y\\) \\(\\lambda = 0\\) provides smooth traversal (fractional) power, logarithm, reciprocal power operations \\(y\\). \\(\\lambda\\) 1, transformation indicated.  boxcox function MASS library trace likelihood function maximized distribution \\(y^*(\\lambda)\\) close Gaussian possible.","code":"opar = par(no.readonly=TRUE) par(mfrow=c(2,2), mar=c(3,2,1,1)) data(fos_ex) hist(fos_ex, main=\"raw\") hist(sqrt(fos_ex), main=\"sqrt\") hist(fos_ex^2, main=\"square\") hist(log(fos_ex), main=\"log\") par(opar) library(MASS) boxcox(fos_ex~1) # must use formula"},{"path":"/articles/S2_EDA.html","id":"exercise","dir":"Articles","previous_headings":"Exploring distributional shape > Transformation","what":"Exercise","title":"S2_EDA: Exploratory data analysis and visualization","text":"3. transformation boxcox() recommend applied log(egr1_ex)? 4. transformation boxcox() recommend applied geyser data started ?","code":""},{"path":"/articles/S2_EDA.html","id":"is-it-gaussian","dir":"Articles","previous_headings":"Exploring distributional shape","what":"Is it Gaussian?","title":"S2_EDA: Exploratory data analysis and visualization","text":"concept Q-Q plot (quantile-quantile plot) used compare given data vector reference distribution (distribution data vector).  configuration points Q-Q plot form straight line, reference distribution probably appropriate.","code":"qqnorm(fos_ex, main=\"Compare FOS to Gaussian distribution\")"},{"path":"/articles/S2_EDA.html","id":"exercises-1","dir":"Articles","previous_headings":"Exploring distributional shape > Is it Gaussian?","what":"Exercises","title":"S2_EDA: Exploratory data analysis and visualization","text":"5. Use qqnorm log(fos_ex) comment. 6. zsc = function(x) (x - mean(x))/sd(x). special qqnorm(zsc(log(fos_ex)))?","code":""},{"path":"/articles/S2_EDA.html","id":"bivariate","dir":"Articles","previous_headings":"Exploring distributional shape","what":"Bivariate","title":"S2_EDA: Exploratory data analysis and visualization","text":"can use density estimation plane reason multimodality bivariate data. example(geom_density_2d):","code":"library(datasets) data(faithful) m <- ggplot(faithful, aes(x = eruptions, y = waiting)) +   geom_point() + xlim(0.5, 6) + ylim(40, 110) # contour lines m + geom_density_2d()"},{"path":"/articles/S2_EDA.html","id":"exercise-1","dir":"Articles","previous_headings":"Exploring distributional shape > Bivariate","what":"Exercise","title":"S2_EDA: Exploratory data analysis and visualization","text":"7. Comment meaning “local modes” “marginal” displays.","code":"opar = par(no.readonly=TRUE) par(mfrow=c(1,2), mar=c(3,2,1,1)) plot(density(faithful$erup, .08)) plot(density(faithful$wait, 1.4)) par(opar)"},{"path":"/articles/S2_EDA.html","id":"exercise-2","dir":"Articles","previous_headings":"Exploring distributional shape > Bivariate","what":"Exercise","title":"S2_EDA: Exploratory data analysis and visualization","text":"8. (advanced): Produce shiny app controller bandwidth density estimator viewing bivariate structure faithful data. ```","code":""},{"path":"/articles/S2_EDA.html","id":"visualizing-data-in-the-context-of-the-genome","dir":"Articles","previous_headings":"","what":"Visualizing data in the context of the genome","title":"S2_EDA: Exploratory data analysis and visualization","text":"use https://vjcitn.shinyapps.io/tnt4dn8 look GWAS eQTL data jointly.","code":""},{"path":"/articles/S2a_PCAelem.html","id":"overview","dir":"Articles","previous_headings":"","what":"Overview","title":"S2a: Elements of PCA","text":"vignette explores basic aspects PCA bivariate 5-dimensional data. concludes remarks “eigengenes”, can verified using computations shown simpler cases.","code":""},{"path":"/articles/S2a_PCAelem.html","id":"make-a-bivariate-dataset-with-positive-correlation-and-heterogeneous-variance","dir":"Articles","previous_headings":"","what":"Make a bivariate dataset with positive correlation and heterogeneous variance","title":"S2a: Elements of PCA","text":"First create covariance matrix greater variance second variable pair. generate 20000 x 2 matrix bivariate normal deviates. data original units easy visualize:  Now perform PCA. don’t reduce dimensions, can get handle components formed interpreted.  PC1 produced taking linear combinations rows sim1. ’ll illustrate linear combination concept. data vector first row may written (x1,x2)(x_1, x_2), linear combination form ax1+bx2ax_1 + bx_2 coefficients aa bb. coefficients derived rotation component PCA. can done wholesale using matrix multiplication %*%: Exercises. Recover value prc$x[1,2] using second column prc$rotation. Examine plots  rotation “undone”. Letting VV denote ‘rotation’ component PCA, shows matrix product VVt=IVV^t = , II diagonal matrix 1 diagonal. background underlying computations can gleaned Wikipedia entry singular value decomposition.","code":"library(MASS) set.seed(1234) options(digits=3) cm = matrix(c(1,1,1,4), nr=2) cm ##      [,1] [,2] ## [1,]    1    1 ## [2,]    1    4 sim1 = mvrnorm(20000, c(0,0), cm) cov(sim1) ##       [,1]  [,2] ## [1,] 1.002 0.995 ## [2,] 0.995 3.973 cor(sim1) ##       [,1]  [,2] ## [1,] 1.000 0.499 ## [2,] 0.499 1.000 plot(sim1,xlim=c(-10,10), ylim=c(-10,10)) prc = prcomp(sim1, center=FALSE) plot(prc$x, xlim=c(-10,10), ylim=c(-10,10)) prc$rotation ##        PC1    PC2 ## [1,] 0.291  0.957 ## [2,] 0.957 -0.291 c11 = prc$rotation[1,1] c21 = prc$rotation[2,1] sim1[1,1]*c11 + sim1[1,2]*c21 ##  PC1  ## -2.5 prc$x[1,1] ##  PC1  ## -2.5 (sim1 %*% prc$rotation)[1:5,] ##         PC1    PC2 ## [1,] -2.502  1.412 ## [2,]  0.576  0.797 ## [3,]  2.250  0.539 ## [4,] -4.866 -0.213 ## [5,]  0.891  1.017 prc$x[1:5,] ##         PC1    PC2 ## [1,] -2.502  1.412 ## [2,]  0.576  0.797 ## [3,]  2.250  0.539 ## [4,] -4.866 -0.213 ## [5,]  0.891  1.017 all.equal(prc$x, sim1%*% prc$rotation) ## [1] TRUE par(mfrow=c(2,2), mar=c(4,4,3,1)) plot(sim1, xlim=c(-10,10), ylim=c(-10,10), main=\"raw data\",   xlab=\"data column 1\", ylab=\"data col. 2\") plot(sim1 %*% prc$rotation, xlim=c(-10,10), ylim=c(-10,10),   main=\"data %*% prc$rotation\", xlab=\"PC1 via rotation\",    ylab=\"PC2 via rotation\") plot(prc$x, xlim=c(-10,10), ylim=c(-10,10), main=\"x from prcomp\",     ) plot(sim1 %*%   prc$rotation %*% t(prc$rotation), xlim=c(-10,10), ylim=c(-10,10),   main=\"data %*% rot %*% t(rot)\", xlab=\"data %*% VVt (col 1)\",   ylab = \"data %*% VVt (col 2)\")"},{"path":"/articles/S2a_PCAelem.html","id":"a-larger-covariance-matrix","dir":"Articles","previous_headings":"","what":"A larger covariance matrix","title":"S2a: Elements of PCA","text":"5-dimensional dataset. set covariance matrix columns 1 2 negative correlation, columns 3 4 positive correlation, column 2 greatest overall variance, columns 1 3 elevated variance. pairs plot shows data original units.  verify multivariate structure: Compute PCA  biplot shows projection PC1-PC2 shows different variables related, drive projection.  Exercise: Explain configuration arrows biplot.","code":"cm = diag(5) cm[3,4] = cm[4,3] = .8 cm[1,2] = cm[2,1] = -.6 A = diag(5) A[1,1] = 2 A[2,2] = 3 A[3,3] = 2 covm = A%*%cm%*%A myd = mvrnorm(2000, rep(0,5), covm) pairs(myd, xlim=c(-10,10), ylim=c(-10,10)) cor(myd) ##          [,1]     [,2]     [,3]     [,4]    [,5] ## [1,]  1.00000 -0.61123 -0.00337  0.01546  0.0489 ## [2,] -0.61123  1.00000 -0.00105  0.00686 -0.0348 ## [3,] -0.00337 -0.00105  1.00000  0.80438 -0.0361 ## [4,]  0.01546  0.00686  0.80438  1.00000 -0.0365 ## [5,]  0.04888 -0.03478 -0.03611 -0.03648  1.0000 cov(myd) ##         [,1]     [,2]     [,3]    [,4]    [,5] ## [1,]  4.1482 -3.88159 -0.01360  0.0317  0.0986 ## [2,] -3.8816  9.72168 -0.00648  0.0215 -0.1075 ## [3,] -0.0136 -0.00648  3.91911  1.6017 -0.0708 ## [4,]  0.0317  0.02153  1.60174  1.0118 -0.0364 ## [5,]  0.0986 -0.10745 -0.07082 -0.0364  0.9816 dim(myd) ## [1] 2000    5 pp = prcomp(myd) pairs(pp$x) par(lwd=2) biplot(pp, xlabs=rep(\".\", 2000), expand=.8)"},{"path":"/articles/S2a_PCAelem.html","id":"eigengenes-derived-from-pca","dir":"Articles","previous_headings":"","what":"“Eigengenes” derived from PCA","title":"S2a: Elements of PCA","text":"rows samples columns genes, x components prcomp’s output linear combinations genes. coefficients combination derived PCA rotation matrix, constructed order PCs components capturing variation come first construct PCs mutually orthogonal Note simple reconstructions required prcomp used center=FALSE.","code":""},{"path":"/articles/S3_distclust.html","id":"road-map","dir":"Articles","previous_headings":"","what":"Road map","title":"S3: Distances, clustering","text":"Distances high-dimensional spaces Criteria agglomerative clustering interactive heatmap comparing Euclidean correlation (1-cor) distances comparing agglomeration methods silhouette measure clustering adequacy","code":""},{"path":"/articles/S3_distclust.html","id":"cluster-analysis-concepts","dir":"Articles","previous_headings":"","what":"Cluster analysis concepts","title":"S3: Distances, clustering","text":"need identify groups similar observations arises many contexts – ultimately service clarifying sources variability, building power statistical comparisons. Hierarchical clustering N multivariate observations conducted starting N clusters proceeding M clusters M-1 (M=N, …, 2) clusters merging two members separated least pairwise distances.","code":""},{"path":[]},{"path":[]},{"path":"/articles/S3_distclust.html","id":"application-inferring-steps-in-tumor-metastasis-in-a-breast-cancer-patient","dir":"Articles","previous_headings":"","what":"Application: inferring steps in tumor metastasis in a breast cancer patient","title":"S3: Distances, clustering","text":"’ll examine data distributed 2021 Genome Biology paper Gabor Marth lab. Clinical sequence interventions. Event sequence.","code":""},{"path":"/articles/S3_distclust.html","id":"a-view-of-copy-number-aberrations-for-1mb-tiling","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient","what":"A view of copy number aberrations for 1Mb tiling","title":"S3: Distances, clustering","text":"28 tumors sampled sequenced rapid autopsy procedure. Copy number variation assessed using FACETS. tissues tumors taken Br (Breast), Bo (Bone), Bn (Brain), Ln (Lung), Lv (Liver), Pa (Pancreas), Ly (Lymph nodes), Kd (Kidney) plotly-based visualization (vertical) ordering tissues chosen exemplify certain similarities. example block blue chr10 seen three samples. indication deletion.","code":""},{"path":"/articles/S3_distclust.html","id":"a-cluster-analysis-proposed-in-support-of-the-evolutionary-map","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient","what":"A cluster analysis proposed in support of the evolutionary map","title":"S3: Distances, clustering","text":"code lightly modified script distributed https://github.com/xiaomengh/tumor-evo-rapid-autopsy.git.","code":"suppressPackageStartupMessages({  library(csamaDist)  library(bioDist)  library(cluster) }) data(cnv_log_R) data = cnv_log_R samples = c('Ln7','Ln9','Ln1','BrM','BrP',            'Ln11','Ly2','Ln3',            'Bo3','Ln10','Bo1','Ln8','Lv3','Ln5','Bo2','Bn2','Bn1','Bn3','Bn4','Ln2',            'Ly1','Ln6',            'Kd1','Ln4','Lv4','Lv2','Lv1','Pa1') rownames(data) = samples d = dist(data, method=\"euclidean\") fit = hclust(d, method=\"average\") # the following line changes the order of the samples to produce the Fig.S3B but doesn't change the phylogenetic relationship fit$order = c(1,4,2,5,3,13,10,20,16,11,12,15,9,17,19,14,18,21,22,7,6,8,25,27,26,28,23,24) plot(fit)"},{"path":[]},{"path":"/articles/S3_distclust.html","id":"comparing-euclidean-and-correlation-distances","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"Comparing Euclidean and Correlation distances","title":"S3: Distances, clustering","text":"given correlation distance value, can wide variation euclidean distance, vice versa. Open question: distance metric relevant biological interpretation CNV?","code":"cd = cor.dist(cnv_log_R) # from bioDist ed = dist(cnv_log_R) plot(as.numeric(ed), as.numeric(cd), xlab=\"All pairwise Euclidean distances\", ylab=\"All pairwise correlation distances\")"},{"path":"/articles/S3_distclust.html","id":"a-pair-with-discrepant-correlation-and-euclidean-distance-values-over-entire-genome","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"A pair with discrepant correlation and euclidean distance values (over entire genome)","title":"S3: Distances, clustering","text":"’ll look first 100Mb chr1.","code":"plot(cnv_log_R[\"Ly1\",1:100],pch=19, main=\"chr1, first 100Mb\", ylab=\"FACETS CNV log R\", xlab=\"chr1\") points(cnv_log_R[\"Ln1\",1:100], col=\"red\",pch=19) legend(60, -.5, pch=19, col=c(\"black\", \"red\"), legend=c(\"Ly1\", \"Ln1\")) #cor(cnv_log_R[\"Ly1\", 1:100], cnv_log_R[\"Ln1\", 1:100]) edist = function(x,y) sqrt(sum((x-y)^2)) edist(cnv_log_R[\"Ly1\", 1:100], cnv_log_R[\"Ln1\", 1:100]) ## [1] 1.685992 plot(jitter(cnv_log_R[\"Ly1\", 1:100]), cnv_log_R[\"Ln1\", 1:100], xlab=\"Ly1\", ylab=\"Ln1\") abline(0,1)"},{"path":"/articles/S3_distclust.html","id":"redo-clustering-with-alternative-distance-and-agglomeration-method","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"Redo clustering with alternative distance and agglomeration method","title":"S3: Distances, clustering","text":"","code":"fit2 = hclust(cd, method=\"ward.D2\") plot(fit2) abline(h=.3, lty=2)"},{"path":"/articles/S3_distclust.html","id":"silhouette-measure","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"Silhouette measure","title":"S3: Distances, clustering","text":"?silhouette cluster library:","code":"For each observation i, the _silhouette width_ s(i) is defined as follows:       Put a(i) = average dissimilarity between i and all other points of      the cluster to which i belongs (if i is the _only_ observation in      its cluster, s(i) := 0 without further calculations).  For all      _other_ clusters C, put d(i,C) = average dissimilarity of i to all      observations of C.  The smallest of these d(i,C) is b(i) := \\min_C      d(i,C), and can be seen as the dissimilarity between i and its      \"neighbor\" cluster, i.e., the nearest one to which it does _not_      belong.  Finally,                     s(i) := ( b(i) - a(i) ) / max( a(i), b(i) ).                     'silhouette.default()' is now based on C code donated by Romain      Francois (the R version being still available as      'cluster:::silhouette.default.R').       Observations with a large s(i) (almost 1) are very well clustered,      a small s(i) (around 0) means that the observation lies between      two clusters, and observations with a negative s(i) are probably      placed in the wrong cluster. ct1 = cutree(fit2, h=.3) c2 = cnv_log_R rownames(c2) = paste(rownames(c2), as.numeric(ct1)) sil = silhouette(ct1, cd) plot(sil)"},{"path":"/articles/S3_distclust.html","id":"exercises","dir":"Articles","previous_headings":"Application: inferring steps in tumor metastasis in a breast cancer patient > Drilling down on the clustering","what":"Exercises","title":"S3: Distances, clustering","text":"1: install bioDist vjcitn/csamaDist. Use code: Comment qualitative differences clusterings. 2: produce report silhouette measurement second clustering. Produce three-cluster partition hc1 obtain silhouette display.","code":"library(csamaDist) data(cnv_log_R) hc1 = hclust(dist(cnv_log_R[1:8,])) hc2 = hclust(bioDist::cor.dist(cnv_log_R[1:8,]), method=\"ward.D2\")  opar = par(no.readonly=TRUE) par(mfrow=c(1,2), mar=c(4,3,1,1)) plot(hc1, main=\"Euc, complete\") plot(hc2, main=\"1-Cor, Ward's D2\") par(opar) assn =  cutree(hc2, h=.25) plot(silhouette( assn, bioDist::cor.dist(cnv_log_R[1:8,])))"},{"path":[]},{"path":"/articles/S3_hypothesis_testing.html","id":"the-fairness-hypothesis","dir":"Articles","previous_headings":"Inference","what":"The fairness hypothesis","title":"S3_inference: Definitions and exercises","text":"Let \\(C_1\\) denote suit top card revealed fair shuffle. can state hypothesis fairness deck repeated draws top card shuffling \\[ H_0: Pr(C_1 = \\heartsuit) = Pr(C_1 = \\diamondsuit) = Pr(C_1 = \\clubsuit) = Pr(C_1 = \\spadesuit) = 1/4 \\] frequentist framework statistical inference, define procedures testing (null) hypotheses specified error probabilities. Type error occurs null hypothesis true test results assertion false. Traditionally try keep probability Type errors 5%. Type II error occurs null hypothesis false test result assertion false. Traditionally try keep probability Type II errors 20%.","code":""},{"path":"/articles/S3_hypothesis_testing.html","id":"exercises","dir":"Articles","previous_headings":"Inference > The fairness hypothesis","what":"Exercises","title":"S3_inference: Definitions and exercises","text":"14: Propose test \\(H_0\\) given . Assume results top card draws 100 shuffles. 15: Consider approach testing \\(H_0\\) basis top card draws \\(N\\) shuffles:","code":""},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":"/articles/S4_hypothesis_testing.html","id":"basic-concepts","dir":"Articles","previous_headings":"Inference","what":"Basic concepts","title":"S4_inference: Definitions and exercises","text":"going focus framework known “null hypothesis significance testing”. “null hypothesis” typically denoted \\(H_0\\) expresses claim often involves lack effect experimental intervention outcome interest. “alternative hypothesis” denoted \\(H_1\\), express specific measurable impact intervention. case card deck chapter S1, typical postulate \\(H_0\\): deck fair, one card combination face suit \\(H_1\\): deck tampered excess hearts Note case, \\(H_1\\) fairly vague – less specific, referring lack fairness. \\(H_1\\) specifies suit excess representation deck, specific severe tampering . experimental design, important clear view sources variation outcome interest, magnitude effect intervention scientifically important. focus can establish operating characteristics proposed experiment. significance testing framework, formalize operating characteristics probabilities inferential error, described . plunge formalities, let’s recall work deck cards. create fair deck: Now let’s create severely biased deck: tools shuffling drawing top card: Let’s make reproducible random draw: Exercise: create vector holding 100 draws biased deck. Estimate probability suit top card diamond. Use test suit draw. example: Note: starting set.seed(2345), estimated probability diamond suit top draw found 0.16.","code":"library(CSHstats) d = build_deck() table(suits(d), faces(d)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 bd = d  # just a copy bd[18] = bd[3] bd[19] = bd[3] bd[20] = bd[4] bd[21] = bd[5] table(suits(bd), faces(bd)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 3 2 2 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 0 0 0 0 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 shuffle_deck = function(d) sample(d, size=length(d), replace=FALSE) top_draw = function(d) shuffle_deck(d)[1] set.seed(1234) t1 = top_draw(bd) t1 ## [1] \"3 ♣\" diamond_sign = function() \"\\U2662\" t1 == diamond_sign() ## [1] FALSE"},{"path":"/articles/S4_hypothesis_testing.html","id":"the-fairness-hypothesis","dir":"Articles","previous_headings":"Inference","what":"The fairness hypothesis","title":"S4_inference: Definitions and exercises","text":"Let \\(C_1\\) denote suit top card revealed fair shuffle. can state hypothesis fairness deck repeated draws top card shuffling \\[ H_0: Pr(C_1 = \\heartsuit) = Pr(C_1 = \\diamondsuit) = Pr(C_1 = \\clubsuit) = Pr(C_1 = \\spadesuit) = 1/4 \\]","code":""},{"path":"/articles/S4_hypothesis_testing.html","id":"operating-characteristics-type-i-and-type-ii-errors","dir":"Articles","previous_headings":"Inference","what":"Operating characteristics: Type I and Type II errors","title":"S4_inference: Definitions and exercises","text":"frequentist framework statistical inference, define procedures testing (null) hypotheses specified error probabilities. Type error occurs null hypothesis true test results assertion false. Traditionally try keep probability Type errors 5%. Type II error occurs null hypothesis false test result assertion false. Traditionally try keep probability Type II errors 20%. Synonyms: often use size synonymous Type error probability, power one minus Type II error probability","code":""},{"path":"/articles/S4_hypothesis_testing.html","id":"exercise","dir":"Articles","previous_headings":"Inference > Operating characteristics: Type I and Type II errors","what":"Exercise","title":"S4_inference: Definitions and exercises","text":"1: Propose procedure testing \\(H_0: Pr(C_1 = \\heartsuit) = 1/4\\). Assume results top card draws N shuffles. procedure look like?","code":""},{"path":"/articles/S4_hypothesis_testing.html","id":"simulating-a-series-of-experiments-parameter-estimate","dir":"Articles","previous_headings":"Inference","what":"Simulating a series of experiments; parameter estimate","title":"S4_inference: Definitions and exercises","text":"100 shuffles estimate probability heart. experimental result consistent \\(H_0\\)? larger sample size:","code":"suppressPackageStartupMessages({ suppressMessages({ library(CSHstats) library(EnvStats) }) }) d = build_deck() shuffle_deck = function(d) sample(d, size=length(d), replace=FALSE) heart_sign = function() \"\\U2661\" set.seed(4141) top_draw = function(d) shuffle_deck(d)[1] N = 100 mydat = replicate(N, suits(top_draw(d))==heart_sign()) phat = function(dat) sum(dat)/length(dat) phat(mydat) ## [1] 0.35 N = 1000 mydat = replicate(N, suits(top_draw(d))==heart_sign()) sum(mydat)/length(mydat) ## [1] 0.243"},{"path":"/articles/S4_hypothesis_testing.html","id":"an-improvised-test","dir":"Articles","previous_headings":"Inference","what":"An improvised test","title":"S4_inference: Definitions and exercises","text":"Let’s use procedure |phat(dat)-.25|>.01 criterion rejecting \\(H_0: Pr(C_1 = \\heartsuit) = 1/4\\) Type error rate fair deck experiment based 100 shuffles? Parameterize “delta”, 0.01 previous run. Let’s get rejection rate estimates two sample sizes: home-cooked test Type error rate much high standard practice, depends sample size.","code":"N = 100 NSIM = 1000 tsts = replicate(NSIM,    abs(mean(replicate(N, suits(top_draw(d))==heart_sign()))-.25)>.01) mean(tsts) ## [1] 0.911 prej = function(delta=.01, nullval=.25, NSIM, N) {  mean(replicate(NSIM,    abs(mean(replicate(N, suits(top_draw(d))==heart_sign()))-nullval)>delta)) } prej(delta=.02, NSIM=1000, N=100) ## [1] 0.655 prej(delta=.02, NSIM=1000, N=500) ## [1] 0.323"},{"path":"/articles/S4_hypothesis_testing.html","id":"a-properly-calibrated-procedure","dir":"Articles","previous_headings":"Inference","what":"A properly calibrated procedure","title":"S4_inference: Definitions and exercises","text":"Let’s instead use built procedure testing hypotheses binomial outcomes. brej function defined two layers: - inner: given N draws, test sum number hearts consistent specified null value (1/4 default), specified Type error rate (argument alpha) - outer: replicate inner process NSIM times obtain NSIM indicator variables taking value 1 test rejected 0 otherwise estimate rejection probabilities taking means indicator variables different experimental replication setups. indication procedure stabilizes Type error rate different designs (sample sizes) can accommodate different significance levels.","code":"brej = function(deck, nullval=.25, alpha=0.05, NSIM, N) {  replicate(NSIM, {    dat = replicate(N, suits(top_draw(deck))==heart_sign())    binom.test(sum(dat), N, nullval)$p.value < alpha    }) } mean(brej(d,NSIM=1000, N=100)) ## [1] 0.054 mean(brej(d,NSIM=1000, N=500)) ## [1] 0.06 mean(brej(d,NSIM=1000, N=100, alpha=0.01)) ## [1] 0.006"},{"path":"/articles/S4_hypothesis_testing.html","id":"power-curve","dir":"Articles","previous_headings":"","what":"Power curve","title":"S4_inference: Definitions and exercises","text":"often useful sketch power test procedure series values element experimental/testing setup. ’ll consider power reject null varies sample size, two alternatives null. make biased deck switching one diamond heart. deck, probability heart 14/52, greater 1/4. kind sample size need get good power detect exception?  two switches, probability heart increases 15/52.  Finally, show null hypothesis (deck fair) rejection rate approximately 0.05 range sample sizes.","code":"bd = d bd[18] = bd[4] table(suits(bd), faces(bd)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 2 1 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 0 1 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 ssizes = c(10,50, 100, 300,750) rejps = sapply(ssizes, function(x) mean(brej(bd, NSIM=100, N=x))) plot(ssizes, rejps, main=\"detect one extra heart\") bd[19] = bd[5] table(suits(bd), faces(bd)) ##     ##     10 2 3 4 5 6 7 8 9 A J K Q ##   ♡  1 1 1 1 2 2 1 1 1 1 1 1 1 ##   ♢  1 1 1 1 1 0 0 1 1 1 1 1 1 ##   ♣  1 1 1 1 1 1 1 1 1 1 1 1 1 ##   ♤  1 1 1 1 1 1 1 1 1 1 1 1 1 rejps = sapply(ssizes, function(x) mean(brej(bd, NSIM=100, N=x))) plot(ssizes, rejps, main=\"detect two extra hearts\") rejps_n = sapply(ssizes, function(x) mean(brej(d, NSIM=100, N=x))) plot(ssizes, rejps_n, main=\"preserve Type I error rate\", ylim=c(0,1)) abline(h=0.05, lty=2)"},{"path":"/articles/S4_hypothesis_testing.html","id":"conclusions","dir":"Articles","previous_headings":"","what":"Conclusions","title":"S4_inference: Definitions and exercises","text":"Classical frequentist inference aims control probabilities errors Type (reject null hypothesis true) Type II (fail reject false null). power test procedure one minus Type II error probability. Typically null hypothesis specifies value parameter population distribution case card deck, hypothesis fairness deck shuffling procedure entails probability drawing heart shuffle 1/4 experimental setup entails probability distribution sum number hearts drawn top card N shuffling events binomial(N,1/4) R’s binom.test given sum number hearts observed, number trials, parameter value defining null hypothesis, desired type error rate, produces critical region using binomial distribution sum falls critical region, null hypothesis rejected Verification achievement desired Type Type II error probabilities testing procedure can pursued via simulation power curve sequence experimental conditions can produced via simulation Analytical tools power computation also available. example, EnvStats package, find exercise reconcile results simulation-based results given . Another find sample size needed achieve 80% power detect single switch diamond heart otherwise fair deck.","code":"library(EnvStats) propTestPower(750, p.or.p1=13/52, p0=.25 ) ## [1] 0.05 propTestPower(750, p.or.p1=14/52, p0=.25 ) ## [1] 0.2348789 propTestPower(750, p.or.p1=15/52, p0=.25 ) ## [1] 0.6742566"},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":"/articles/S5_linear_models.html","id":"error-rates-size-and-power","dir":"Articles","previous_headings":"Review of some inference concepts","what":"Error rates: size and power","title":"S5_inference: FDR, linear models, and GLMs","text":"Null hypothesis testing framework: typically aim assess whether intervention affects parameter value certain population average value quantity change treatment? changing composition deck cards affect probability seeing given suit drawing card? Type error: reject null actually true Type II error: fail reject null actually false","code":""},{"path":"/articles/S5_linear_models.html","id":"p-value-a-condensation-of-the-data-and-assumptions","dir":"Articles","previous_headings":"Review of some inference concepts","what":"p-value: a condensation of the data and assumptions","title":"S5_inference: FDR, linear models, and GLMs","text":"p-value test probability observing statistic seen experiment extreme value statistic given null hypothesis true. two-sided p-value obtained via results 27 hearts seen, 22 fewer hearts seen “extreme” observed. p-value probability, value reflects uncertainty assessment relation data null hypothesis. Large p-values suggest much reason use data reject null hypothesis; small p-values suggest either null hypothesis false rare event occurred.","code":"binom.test(27, 100, 1/4) ##  ##  Exact binomial test ##  ## data:  27 and 100 ## number of successes = 27, number of trials = 100, p-value = 0.6446 ## alternative hypothesis: true probability of success is not equal to 0.25 ## 95 percent confidence interval: ##  0.1860664 0.3680163 ## sample estimates: ## probability of success  ##                   0.27 sum(dbinom(27:100, 100, .25))+sum(dbinom(1:22,100, .25)) ## [1] 0.6446304"},{"path":"/articles/S5_linear_models.html","id":"confidence-interval-an-alternative-expression-of-uncertainty","dir":"Articles","previous_headings":"Review of some inference concepts","what":"Confidence interval: an alternative expression of uncertainty","title":"S5_inference: FDR, linear models, and GLMs","text":"observed 30 hearts 100 top-card draws, test report : confidence interval random interval derived data property include true value population parameter interest specified probability.  Exercise: value statistic reject null hypothesis probability 1/4 heart? Exercise: Use 99% coverage probability produce display.","code":"binom.test(30, 100, 1/4) ##  ##  Exact binomial test ##  ## data:  30 and 100 ## number of successes = 30, number of trials = 100, p-value = 0.2491 ## alternative hypothesis: true probability of success is not equal to 0.25 ## 95 percent confidence interval: ##  0.2124064 0.3998147 ## sample estimates: ## probability of success  ##                    0.3 stats = c(27:42) tests = lapply(stats, function(x) binom.test(x, 100, .25)) low = sapply(tests, function(x) x$conf.int[1]) hi = sapply(tests, function(x) x$conf.int[2]) ests = sapply(tests, \"[[\", \"statistic\") plot(stats, ests, ylim=c(0, .6), main=\"95% Confidence intervals\", xlab=\"# hearts seen in 100 draws\",   ylab=\"estimated proportion of hearts\") segments( stats, low, stats, hi) abline(h=.25, lty=2)"},{"path":"/articles/S5_linear_models.html","id":"multiple-comparisons","dir":"Articles","previous_headings":"","what":"Multiple comparisons","title":"S5_inference: FDR, linear models, and GLMs","text":"Everything ’ve seen thus far looks single test various ways. hallmark work genomics necessity performing many tests, large number features hypotheses play. Fact: many tests conducted true null hypotheses, distribution collection p-values thereby obtained uniform (0,1]. illustrate produce 10000 samples N(100,1) conduct t test null mean 100, yielding 10000 p-values.  display shows limitation density estimation fixed interval – “boundary effect”, data “” boundary get sparser get closer boundary. consistent property uniform distribution [0,1]: true density 1.","code":"many_x = replicate(10000, rnorm(10, 100)) many_p = apply(many_x, 2, function(x) t.test(x, mu=100)$p.value) plot(density(many_p, from=0, to=1))"},{"path":"/articles/S5_linear_models.html","id":"bonferronis-correction-to-achieve-family-wise-error-rate-fwer-control","dir":"Articles","previous_headings":"Multiple comparisons","what":"Bonferroni’s correction to achieve Family-Wise Error Rate (FWER) control","title":"S5_inference: FDR, linear models, and GLMs","text":"concept Type error general, deployed define operating characteristics kind inference procedure. table frequently seen discussions multiple testing, Holmes Huber’s Modern Statistics Modern Biology. decisiontab Suppose \\(m\\) hypotheses test wish overall probability family tests Type error rate \\(\\alpha\\). Using table symbols, \\(Pr(V>0) < \\alpha\\). Bonferroni’s method declare significance tests \\(p\\)-value less \\(\\alpha/m\\). procedure (related improvements FWER control) also implies transformation \\(p\\)-values, see shortly.","code":""},{"path":"/articles/S5_linear_models.html","id":"false-discovery-rate","dir":"Articles","previous_headings":"Multiple comparisons","what":"False discovery rate","title":"S5_inference: FDR, linear models, and GLMs","text":"Referring table , false discovery rate (FDR) expected value \\(V/max(R,1)\\). \\(R = 0\\), \\(V = 0\\) FDR zero. Otherwise, can think FDR kind budget: reject \\(R\\) hypotheses expection \\(V\\) false. “following ” confirmatory experiments \\(R\\) genes can afford “wasting” \\(V\\) tests, accept FDR \\(V/R\\). course probabilistic characteristics procedures hold stated probabilities assumptions satisfied.","code":""},{"path":"/articles/S5_linear_models.html","id":"adjusted-p-values","dir":"Articles","previous_headings":"Multiple comparisons","what":"Adjusted p-values","title":"S5_inference: FDR, linear models, and GLMs","text":"Since accustomed single-number summary \\(p\\), typical base rejection decisions transformed \\(p\\)-values. multtest package takes care . default, mt.rawp2adp produces number adjustments – concerned present columns rawp (p-values sorted lowest ), Bonferroni (gives transformation \\(p\\) min(1, mp)$ \\(m\\) tests), BH (Benjamini-Hochberg FDR transformation). implication table FWER control 0.05, data support rejection hypotheses (assert mean sample 10 random normals equal 100). Likewise FDR control value 0.77. However, see accepted FDR control 0.8, reject 8 hypotheses. Exercise: replace first p-value many_p 1e-6 obtain associated adjusted p-values.","code":"library(multtest) options(digits=3) tab = mt.rawp2adjp(many_p) head(tab[[1]],10) ##           rawp Bonferroni  Holm Hochberg SidakSS SidakSD    BH BY   ABH ##  [1,] 9.27e-05      0.927 0.927    0.927   0.604   0.604 0.645  1 0.645 ##  [2,] 1.81e-04      1.000 1.000    1.000   0.836   0.836 0.645  1 0.645 ##  [3,] 3.93e-04      1.000 1.000    1.000   0.980   0.980 0.645  1 0.645 ##  [4,] 4.35e-04      1.000 1.000    1.000   0.987   0.987 0.645  1 0.645 ##  [5,] 4.40e-04      1.000 1.000    1.000   0.988   0.988 0.645  1 0.645 ##  [6,] 4.43e-04      1.000 1.000    1.000   0.988   0.988 0.645  1 0.645 ##  [7,] 4.96e-04      1.000 1.000    1.000   0.993   0.993 0.645  1 0.645 ##  [8,] 6.28e-04      1.000 1.000    1.000   0.998   0.998 0.645  1 0.645 ##  [9,] 6.82e-04      1.000 1.000    1.000   0.999   0.999 0.645  1 0.645 ## [10,] 7.14e-04      1.000 1.000    1.000   0.999   0.999 0.645  1 0.645 ##       TSBH_0.05 ##  [1,]     0.645 ##  [2,]     0.645 ##  [3,]     0.645 ##  [4,]     0.645 ##  [5,]     0.645 ##  [6,]     0.645 ##  [7,]     0.645 ##  [8,]     0.645 ##  [9,]     0.645 ## [10,]     0.645"},{"path":"/articles/S5_linear_models.html","id":"adjustments-via-weighted-fdr","dir":"Articles","previous_headings":"Multiple comparisons","what":"Adjustments via weighted FDR","title":"S5_inference: FDR, linear models, and GLMs","text":"useful review available. section addresses one methods review, found good performance, though contexts authors’ alternatives appear superior.","code":""},{"path":"/articles/S5_linear_models.html","id":"setup","dir":"Articles","previous_headings":"Multiple comparisons > Adjustments via weighted FDR","what":"Setup","title":"S5_inference: FDR, linear models, and GLMs","text":"need IHW package visualization well. ’s key resource p-values want interpret. variant-expression association tests conducted GTEx project. Thus small excerpt collection “GWAS”, outcome tissue-specific expression gene, predictors formed SNP genotypes adjustments carried GTEx analysis pipeline. ’s composite manhattan plot:","code":"library(CSHstats)  library(ggplot2)  library(plotly)  library(IHW)  library(multtest) data(gtex_exc_chr20_b38) gtdat = gtex_exc_chr20_b38 head(gtdat,3) ##   chr pos_b38       marker         rsid effectallele otherallele    eaf     p ## 1  20   61066 20:61066:T:C rs1031667049            C           T 0.0285 0.774 ## 2  20   61083 20:61083:C:T  rs956068117            T           C 0.1010 0.767 ## 3  20   61098 20:61098:C:T  rs933208784            T           C 0.0155 0.117 ##      beta     se              pheno mode       tag imputersq   n     Gene ## 1  0.0226 0.0784 ENSG00000196476.11 eqtl GTEx-eqtl        NA 515 C20orf96 ## 2  0.0123 0.0413 ENSG00000196476.11 eqtl GTEx-eqtl        NA 515 C20orf96 ## 3 -0.1615 0.1029 ENSG00000196476.11 eqtl GTEx-eqtl        NA 515 C20orf96 ##   seqnames  start    end width strand         gene_id gene_name   gene_biotype ## 1       20 270863 290778 19916      - ENSG00000196476  C20orf96 protein_coding ## 2       20 270863 290778 19916      - ENSG00000196476  C20orf96 protein_coding ## 3       20 270863 290778 19916      - ENSG00000196476  C20orf96 protein_coding ##   seq_coord_system   symbol entrezid ## 1       chromosome C20orf96   140680 ## 2       chromosome C20orf96   140680 ## 3       chromosome C20orf96   140680 pl1 = ggplot(gtdat[gtdat$p<.1,], aes(x=pos_b38, y=-log10(p), colour=Gene)) + geom_point() #ggplotly(pl1) pl1"},{"path":"/articles/S5_linear_models.html","id":"demonstration-1-use-allele-frequency-to-form-strata-for-fdr-weighting","dir":"Articles","previous_headings":"Multiple comparisons > Adjustments via weighted FDR","what":"Demonstration 1: Use allele frequency to form strata for FDR weighting","title":"S5_inference: FDR, linear models, and GLMs","text":"eaf field frequency “effect allele” reported SNP-Nexus. run IHW algorithm using variant frequency strata, conjecture rare common variants may downweighted way advantageous discovery. weighting procedure involves random resampling data, reduce risk overfitting, allow assessment consistency across multiple “folds” random subsets.  Compare weighted, unweighted, conventional rejection numbers:","code":"covariate1 = cut(gtdat$eaf, c(0,.01,.05,.1,.3,.6)) table(covariate1) ## covariate1 ##    (0,0.01] (0.01,0.05]  (0.05,0.1]   (0.1,0.3]   (0.3,0.6]  ##        3865       33697       13860       27840       20738 demo1 = ihw(gtdat$p, covariate1, alpha=0.05) basic_fdr = mt.rawp2adjp(gtdat$p) plot(demo1) newp = adj_pvalues(demo1) sum(newp < 0.05) ## [1] 276 sum(basic_fdr$adjp[,\"BH\"] < 0.05) ## [1] 257 sum(gtdat$p < 5e-8) ## [1] 68"},{"path":"/articles/S5_linear_models.html","id":"demonstration-2-use-distance-to-gene-to-weight","dir":"Articles","previous_headings":"Multiple comparisons > Adjustments via weighted FDR","what":"Demonstration 2: Use distance to gene to weight","title":"S5_inference: FDR, linear models, and GLMs","text":"","code":"dist2gene = abs(gtdat$pos_b38-gtdat$start) covariate2 = cut(dist2gene, 5) ok = which(!is.na(covariate2)) demo2 = ihw(gtdat$p[ok], covariate2[ok], alpha=0.05) plot(demo2) newp2 = adj_pvalues(demo2) sum(newp2 < 0.05) ## [1] 379"},{"path":"/articles/S5_linear_models.html","id":"optional-considerations-on-bayesian-multiple-testing","dir":"Articles","previous_headings":"Multiple comparisons","what":"Optional: Considerations on Bayesian multiple testing","title":"S5_inference: FDR, linear models, and GLMs","text":"Various comments references stackexchange address relationship inferential framework approach multiple testing. paper Gelman Loken surveys concept illuminating way. paper European Journal Epidemiology presents considerations multiple comparisons Bayesian perspective, arguing issue “surrounded confusion controversy”. simple approach visualizing 20 tests, assumed independent, frequenist framework, focusing 95% confidence intervals.  One hypothesis rejected. authors also use bayesm package produce Bayesian credible intervals assumption tests independent.  Finally, allowing high correlatedness among test statistics, Bayesian approach found avoid false rejections.  Bayesian computations involve Monte Carlo Markov Chain simulation. Background can obtained Statistical Rethinking R. McElreath.","code":"# from https://link.springer.com/content/pdf/10.1007/s10654-019-00517-2.pdf # Sjolander and vanSteenlandt 2019 Eur J Epi  library(forestplot) library(bayesm) set.seed(1)  n = 10 J = 20 beta = 0 Y = matrix(rnorm(n*J, mean=beta), nrow=n, ncol=J) est = colMeans(Y) se = apply(X=Y, MARGIN=2, FUN=sd)/sqrt(n) q = qt(p=0.975, df=n-1) ci.l = est-q*se ci.u = est+q*se  forestplot(  labeltext=rep(\"\", J),  mean=est, lower=ci.l,  upper=ci.u, ci.vertices=TRUE,  boxsize=0.3, txt_gp=fpTxtGp(cex=2),  xticks=seq(-1.5,1.5,.5), title=\"Frequentist 95% confidence intervals\") forestplot(  labeltext=rep(\"\", J),  mean=est, lower=ci.l,  upper=ci.u, ci.vertices=TRUE,  boxsize=0.3, txt_gp=fpTxtGp(cex=2),  xticks=seq(-1.5,1.5,.5), title=\"Bayesian, assume correlated tests\")"},{"path":[]},{"path":"/articles/S5_linear_models.html","id":"data-setup","dir":"Articles","previous_headings":"Linear models","what":"Data setup","title":"S5_inference: FDR, linear models, and GLMs","text":"Let’s return TCGA ACC FOS EGR1 data used study correlation.  found log transformation useful ameliorating overplotting near origin:  ACC data annotated MultiAssayExperiment, mutation summary called OncoSign available.","code":"data(fos_ex) data(egr1_ex) fedf = data.frame(FOS=fos_ex, EGR1=egr1_ex) library(ggplot2) ggplot(fedf, aes(x=EGR1, y=FOS)) + geom_point() ggplot(fedf, aes(x=EGR1, y=FOS)) + geom_point() + scale_x_log10() + scale_y_log10() library(MultiAssayExperiment) library(CSHstats) data(accex) accex ## A MultiAssayExperiment object of 1 listed ##  experiment with a user-defined name and respective class. ##  Containing an ExperimentList class object of length 1: ##  [1] ACC_RNASeq2GeneNorm-20160128: SummarizedExperiment with 20501 rows and 79 columns ## Functionality: ##  experiments() - obtain the ExperimentList instance ##  colData() - the primary/phenotype DataFrame ##  sampleMap() - the sample coordination DataFrame ##  `$`, `[`, `[[` - extract colData columns, subset, or experiment ##  *Format() - convert into a long or wide DataFrame ##  assays() - convert ExperimentList to a SimpleList of matrices ##  exportClass() - save data to flat files table(accex$OncoSign, exclude=NULL) ##  ##          CN1          CN2       CTNNB1   TERT/ZNRF3     TP53/NF1 Unclassified  ##            4           13            5           17           21           14  ##         <NA>  ##            5"},{"path":"/articles/S5_linear_models.html","id":"re-expressing-the-two-sample-test","dir":"Articles","previous_headings":"Linear models","what":"Re-expressing the two-sample test","title":"S5_inference: FDR, linear models, and GLMs","text":"focus two OncoSign classes, asking whether average log EGR1 expression different .","code":"hasonc = which(!is.na(accex$OncoSign)) ndf = data.frame(logEGR1 = log(egr1_ex[hasonc]), oncosign=accex$OncoSign[hasonc]) tpvtert = ndf |> dplyr::filter(oncosign %in% c(\"TP53/NF1\", \"TERT/ZNRF3\")) ggplot(tpvtert, aes(y=logEGR1, x=factor(oncosign))) + geom_boxplot()"},{"path":"/articles/S5_linear_models.html","id":"there-are-two-t-tests","dir":"Articles","previous_headings":"Linear models > Re-expressing the two-sample test","what":"There are two t tests","title":"S5_inference: FDR, linear models, and GLMs","text":"","code":"options(digits=6) t.test(logEGR1~oncosign, data=tpvtert, var.equal=TRUE) ##  ##  Two Sample t-test ##  ## data:  logEGR1 by oncosign ## t = 1.038, df = 36, p-value = 0.306 ## alternative hypothesis: true difference in means between group TERT/ZNRF3 and group TP53/NF1 is not equal to 0 ## 95 percent confidence interval: ##  -0.374199  1.158895 ## sample estimates: ## mean in group TERT/ZNRF3   mean in group TP53/NF1  ##                  7.35317                  6.96083 t.test(logEGR1~oncosign, data=tpvtert, var.equal=FALSE) # more general ##  ##  Welch Two Sample t-test ##  ## data:  logEGR1 by oncosign ## t = 1.046, df = 35.19, p-value = 0.303 ## alternative hypothesis: true difference in means between group TERT/ZNRF3 and group TP53/NF1 is not equal to 0 ## 95 percent confidence interval: ##  -0.369343  1.154039 ## sample estimates: ## mean in group TERT/ZNRF3   mean in group TP53/NF1  ##                  7.35317                  6.96083"},{"path":"/articles/S5_linear_models.html","id":"the-linear-model-has-one-of-these-as-a-special-case","dir":"Articles","previous_headings":"Linear models > Re-expressing the two-sample test","what":"The linear model has one of these as a special case","title":"S5_inference: FDR, linear models, and GLMs","text":"general form linear model statistics “dependent variable” \\(y\\) \\[ y = \\alpha + x' \\beta + e \\] \\(x\\) p-vector “covariates” – measurements believed affect mean value \\(y\\), also known “independent variables”, \\(e\\) zero-mean disturbance residual fixed dispersion. parameters interest \\(\\alpha\\) (often called intercept) \\(\\beta\\). Parameter interpretation terms units response relative differences samples different values \\(x\\) always explicit.","code":""},{"path":"/articles/S5_linear_models.html","id":"a-dummy-variable-design-matrix","dir":"Articles","previous_headings":"Linear models > Re-expressing the two-sample test > The linear model has one of these as a special case","what":"A dummy variable design matrix","title":"S5_inference: FDR, linear models, and GLMs","text":"","code":"mm = model.matrix(~oncosign, data=tpvtert) head(mm) ##   (Intercept) oncosignTP53/NF1 ## 1           1                1 ## 2           1                1 ## 3           1                0 ## 4           1                1 ## 5           1                0 ## 6           1                1 tail(mm) ##    (Intercept) oncosignTP53/NF1 ## 33           1                0 ## 34           1                1 ## 35           1                0 ## 36           1                0 ## 37           1                1 ## 38           1                1"},{"path":"/articles/S5_linear_models.html","id":"recovering-the-t-test-with-lm","dir":"Articles","previous_headings":"Linear models > Re-expressing the two-sample test > The linear model has one of these as a special case","what":"Recovering the t test with lm","title":"S5_inference: FDR, linear models, and GLMs","text":"Exercise: t test recovered analysis? Exercise: Conduct associated Wilcoxon test. Exercise: Conduct Gaussian rank test mentioned Gelman blog “Don’t Wilcoxon”. Extra goody: produce coefficients “hand”: programs \\((X'X)^{-1}X'y\\)","code":"tpvtert |> lm(logEGR1~oncosign, data=_) |> summary() ##  ## Call: ## lm(formula = logEGR1 ~ oncosign, data = tpvtert) ##  ## Residuals: ##    Min     1Q Median     3Q    Max  ## -2.287 -0.721  0.167  0.625  2.549  ##  ## Coefficients: ##                  Estimate Std. Error t value Pr(>|t|)     ## (Intercept)         7.353      0.281   26.17   <2e-16 *** ## oncosignTP53/NF1   -0.392      0.378   -1.04     0.31     ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## Residual standard error: 1.16 on 36 degrees of freedom ## Multiple R-squared:  0.0291, Adjusted R-squared:  0.00209  ## F-statistic: 1.08 on 1 and 36 DF,  p-value: 0.306 solve(t(mm)%*%mm)%*%t(mm)%*%tpvtert$logEGR1 ##                       [,1] ## (Intercept)       7.353174 ## oncosignTP53/NF1 -0.392348"},{"path":"/articles/S5_linear_models.html","id":"analysis-of-variance-f-test","dir":"Articles","previous_headings":"Linear models","what":"Analysis of variance: F test","title":"S5_inference: FDR, linear models, and GLMs","text":"analysis variance focused comparison multiple groups. EGR1-OncoSign relationship reasonable example used.","code":"ggplot(ndf, aes(y=logEGR1, x=factor(oncosign))) + geom_boxplot() nda = aov(logEGR1~factor(oncosign), data=ndf) nda ## Call: ##    aov(formula = logEGR1 ~ factor(oncosign), data = ndf) ##  ## Terms: ##                 factor(oncosign) Residuals ## Sum of Squares           11.3084   92.1642 ## Deg. of Freedom                5        68 ##  ## Residual standard error: 1.1642 ## Estimated effects may be unbalanced summary(nda) ##                  Df Sum Sq Mean Sq F value Pr(>F) ## factor(oncosign)  5   11.3    2.26    1.67   0.15 ## Residuals        68   92.2    1.35"},{"path":"/articles/S5_linear_models.html","id":"linear-regression-parameter-estimation-goodness-of-fit","dir":"Articles","previous_headings":"Linear models","what":"Linear regression, parameter estimation, goodness of fit","title":"S5_inference: FDR, linear models, and GLMs","text":"common applications linear modeling take advantage continuity predictor. simple linear regression (one continuous covariate), interpretation \\(\\beta\\) : difference mean \\(y\\) associated unit difference \\(x\\). Regarding log EGR1 predictor log FOS, ","code":"m1 = lm(log(fos_ex)~log(egr1_ex)) summary(m1) ##  ## Call: ## lm(formula = log(fos_ex) ~ log(egr1_ex)) ##  ## Residuals: ##    Min     1Q Median     3Q    Max  ## -1.545 -0.482  0.198  0.476  1.397  ##  ## Coefficients: ##              Estimate Std. Error t value Pr(>|t|)     ## (Intercept)    2.2980     0.4975    4.62  1.5e-05 *** ## log(egr1_ex)   0.6895     0.0692    9.96  1.8e-15 *** ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## Residual standard error: 0.727 on 77 degrees of freedom ## Multiple R-squared:  0.563,  Adjusted R-squared:  0.557  ## F-statistic: 99.1 on 1 and 77 DF,  p-value: 1.75e-15 plot(m1)"},{"path":[]},{"path":"/articles/S5_linear_models.html","id":"glms-binary-counted-non-gaussian-responses","dir":"Articles","previous_headings":"","what":"GLMs: binary, counted, non-Gaussian responses","title":"S5_inference: FDR, linear models, and GLMs","text":"family generalized linear models (GLM) embraces number approaches statistical inference associations non-Gaussian responses general configurations covariates.","code":""},{"path":"/articles/S5_linear_models.html","id":"prologue-fishers-exact-test-for-2-x-2-table","dir":"Articles","previous_headings":"GLMs: binary, counted, non-Gaussian responses","what":"Prologue: Fisher’s exact test for 2 x 2 table","title":"S5_inference: FDR, linear models, and GLMs","text":"’ll work FOS EGR1 artificial way. ’ll suppose criteria “activation”: FOS activated RNA-seq measurement ACC exceeds 1000 EGR1 activated RNA-seq measurement ACC exceeds 2000 form 2 x 2 cross classification tumors using definitions: basic question whether two events “EGR1 activated” “FOS activated” statistically associated ACC tumors. Fisher’s exact test evaluates hypergeometric distribution (1,1) cell table, given marginal totals. odds event occurs probability \\(p\\) given \\(p/(1-p)\\). Abbreviate \\(odds(p)\\) odds ratio two events probabilities \\(p_1\\) \\(p_2\\) \\(odds(p_1)/odds(p_2)\\). 2x2 table can estimated cross ratio “ad/bc”. odds ratio estimated fisher.test different, conditional maximum likelihood estimate. difference seldom meaningful.","code":"library(CSHstats) data(fos_ex) data(egr1_ex) fos_act = 1*(fos_ex > 1000) egr1_act = 1*(egr1_ex > 2000) acttab = table(fos_act=fos_act, egr1_act=egr1_act) acttab ##        egr1_act ## fos_act  0  1 ##       0 26  5 ##       1 25 23 fisher.test(acttab, alternative=\"greater\") # one-sided ##  ##  Fisher's Exact Test for Count Data ##  ## data:  acttab ## p-value = 0.0034 ## alternative hypothesis: true odds ratio is greater than 1 ## 95 percent confidence interval: ##  1.68701     Inf ## sample estimates: ## odds ratio  ##    4.69113 sum(dhyper(26:31, 51, 28, 31)) ## [1] 0.00339765 odds = function(x) {p=mean(x); p/(1-p)} odds(fos_act[egr1_act==TRUE])/odds(fos_act[egr1_act==FALSE]) ## [1] 4.784 acttab[1,1]*acttab[2,2]/(acttab[1,2]*acttab[2,1]) ## [1] 4.784"},{"path":"/articles/S5_linear_models.html","id":"binary-response-logistic-regression","dir":"Articles","previous_headings":"GLMs: binary, counted, non-Gaussian responses","what":"Binary response: logistic regression","title":"S5_inference: FDR, linear models, and GLMs","text":"model conditional probability FOS activated, depending whether note EGR1 activated, using definitions given . model form \\[ \\mbox{logit} Pr(FOS > 1000|EGR1>2000) = \\alpha + \\beta x \\] logit(p) = log(p/(1-p)) called “link function”. transforms outcome interest (probability) interval (0,1) whole real line. interpretation \\(\\beta\\) : “log odds ratio”. exponentiate beta, obtain effect change x one unit odds response event. Parameter interpretation. intercept parameter value -0.0392, logit probability FOS activated, given EGR1 activated. “beta” parameter log odds ratio (comparing probability FOS activation EGR1 conditions – activated activated).","code":"g1 = glm(fos_act ~ egr1_act, family=binomial()) summary(g1) ##  ## Call: ## glm(formula = fos_act ~ egr1_act, family = binomial()) ##  ## Coefficients: ##             Estimate Std. Error z value Pr(>|z|)    ## (Intercept)  -0.0392     0.2801   -0.14   0.8886    ## egr1_act      1.5653     0.5673    2.76   0.0058 ** ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## (Dispersion parameter for binomial family taken to be 1) ##  ##     Null deviance: 105.830  on 78  degrees of freedom ## Residual deviance:  96.958  on 77  degrees of freedom ## AIC: 101 ##  ## Number of Fisher Scoring iterations: 3 log(4.784) ## [1] 1.56528"},{"path":"/articles/S5_linear_models.html","id":"multiple-logistic-regression","dir":"Articles","previous_headings":"GLMs: binary, counted, non-Gaussian responses","what":"Multiple logistic regression","title":"S5_inference: FDR, linear models, and GLMs","text":"Fisher’s exact test simple logistic regression seen consistent one another example. advantage logistic regression framework potential sources variation probability response can incorporated. data YY1 expression ACC declare activated expressed level greater 1500. inclusion information YY1 seem informative FOS activation.","code":"data(yy1_ex) yy1_act = yy1_ex > 1500 g2 = glm(fos_act ~ egr1_act+yy1_act, family=binomial()) summary(g2) ##  ## Call: ## glm(formula = fos_act ~ egr1_act + yy1_act, family = binomial()) ##  ## Coefficients: ##             Estimate Std. Error z value Pr(>|z|)    ## (Intercept)   0.0922     0.3175    0.29   0.7716    ## egr1_act      1.5690     0.5702    2.75   0.0059 ** ## yy1_actTRUE  -0.4833     0.5472   -0.88   0.3771    ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## (Dispersion parameter for binomial family taken to be 1) ##  ##     Null deviance: 105.830  on 78  degrees of freedom ## Residual deviance:  96.177  on 76  degrees of freedom ## AIC: 102.2 ##  ## Number of Fisher Scoring iterations: 3"},{"path":"/articles/S5_linear_models.html","id":"general-case-link-and-variance-functions","dir":"Articles","previous_headings":"GLMs: binary, counted, non-Gaussian responses","what":"General case: link and variance functions","title":"S5_inference: FDR, linear models, and GLMs","text":"family generalized linear models can accommodate many forms variation response interest, associated number “predictor” variables. DESeq2 edgeR use negative binomial GLM inference differential expression RNA-seq. hear much . glm.nb function MASS package allows fit negative binomial regressions data data.frames.","code":"kable(glmtab)"},{"path":"/articles/S5_linear_models.html","id":"hierarchical-models-alternatives-to-independence","dir":"Articles","previous_headings":"","what":"Hierarchical models: alternatives to independence","title":"S5_inference: FDR, linear models, and GLMs","text":"strong assumption use linear generalized linear models mutual independence reponses. clustering responses present (example, analyzing data collected human families, pairs eyes, mice litters), additional model structure introduced accommodate lack independence.","code":""},{"path":"/articles/S5_linear_models.html","id":"random-effects-models-for-clustered-observations","dir":"Articles","previous_headings":"Hierarchical models: alternatives to independence","what":"Random effects models for clustered observations","title":"S5_inference: FDR, linear models, and GLMs","text":"framework approach developed 1982 (Laird Ware) expands linear model model known “mixed effects”: \\[ y_{ij} = \\alpha + \\beta x_{ij} + a_i + e_{ij} \\] \\(\\) indexing clusters \\(j\\) responses within clusters. “random effect” \\(a_i\\) assumed follow \\(N(0, \\sigma^2_b)\\) (-cluster variance), independent \\(e_{ij} \\sim N(0, \\sigma^2_w)\\). intraclass correlation coefficient measures departure independence, form \\(\\rho = \\sigma^2_b/(\\sigma^2_b + \\sigma^2_w)\\). Approximate mixed effects models GLM families can fit using glmmPQL MASS.","code":""},{"path":"/articles/S5a_lmdiagnostics.html","id":"fast-forward","dir":"Articles","previous_headings":"","what":"Fast forward","title":"S5a: Diagnostics of a differential gene expression exercise","text":"document shows SRP045638 can retrieved analyzed. start filtered normalized data vGene object. model matrix also important: top results limma-voom analysis: little different de_results computed class document – sort p take significant results.","code":"library(edgeR) library(CSHstats) data(vGene) names(vGene) ## [1] \"genes\"   \"targets\" \"E\"       \"weights\" \"design\" head(vGene$E[,1:5]) ##                   SRR2071341  SRR2071345 SRR2071346 SRR2071347 SRR2071348 ## ENSG00000223972.5 -1.6548376 -3.43059162 -3.3104740  -2.641761 -3.9493303 ## ENSG00000278267.1 -0.6717114 -0.19793086 -0.5977559  -2.156334  0.1381326 ## ENSG00000227232.5  3.7573137  4.60832737  4.2686324   3.335519  4.5823511 ## ENSG00000284332.1 -5.4961399 -5.75251971 -6.4803990  -4.963689 -7.6497700 ## ENSG00000243485.5 -0.3668569 -0.02459926 -0.6475089  -3.378727  0.6310008 ## ENSG00000237613.2 -5.4961399 -3.43059162 -4.1584709  -2.641761 -6.0648075 data(mod) head(mod) ##            (Intercept) prenatalprenatal sra_attribute.RIN sra_attribute.sexmale ## SRR2071341           1                0               8.3                     0 ## SRR2071345           1                0               8.4                     1 ## SRR2071346           1                0               8.7                     1 ## SRR2071347           1                0               5.3                     0 ## SRR2071348           1                1               9.6                     0 ## SRR2071349           1                1               6.4                     0 ##            assigned_gene_prop ## SRR2071341          0.4376474 ## SRR2071345          0.7776021 ## SRR2071346          0.8054366 ## SRR2071347          0.8374639 ## SRR2071348          0.6956363 ## SRR2071349          0.6855766 data(de_results) options(digits=3) de_results[1:5, c(\"gene_name\", \"logFC\", \"t\", \"P.Value\", \"adj.P.Val\")] ##                    gene_name logFC    t  P.Value adj.P.Val ## ENSG00000121210.15  KIAA0922  3.28 41.9 4.24e-49  1.99e-44 ## ENSG00000143494.15     VASH2  5.44 37.9 2.56e-46  6.01e-42 ## ENSG00000176371.13    ZSCAN2  2.74 36.6 2.14e-45  3.34e-41 ## ENSG00000196150.13    ZNF250  2.51 35.7 1.07e-44  1.25e-40 ## ENSG00000103044.10      HAS3  2.49 35.1 2.69e-44  2.53e-40"},{"path":"/articles/S5a_lmdiagnostics.html","id":"assessing-the-association-by-hand","dir":"Articles","previous_headings":"","what":"Assessing the association “by hand”","title":"S5a: Diagnostics of a differential gene expression exercise","text":"vGene$E structure holds estimated expression values, vGene$weights quantities measure relative variability quantities E. can pick gene interest examine marginal distribution estimate association. top DE gene “ENSG00000121210.15”. Let’s make data.frame E values, covariates, weights. Now examine marginal distribution:  Interesting. ’s big gap KIAA0922 expression distribution. Exercise: true “raw” data, artifact computations ’ve done?  Finally, fit linear model:","code":"target = \"ENSG00000121210.15\" ind = which(rownames(vGene$E)==target) mydf = data.frame(cbind(KIAA0922=vGene$E[ind,],       mod[,-1], wts=vGene$weights[ind,])) hist(mydf$KIAA0922) library(beeswarm) beeswarm(mydf$KIAA0922, pwcol=as.numeric(factor(mydf$prenatalprenatal))) legend(.6,6,legend=c(\"postnatal\", \"prenatal\"), col=c(1,2), pch=19) m1 = lm(KIAA0922~.-wts, data=mydf, weights=wts) summary(m1) ##  ## Call: ## lm(formula = KIAA0922 ~ . - wts, data = mydf, weights = wts) ##  ## Weighted Residuals: ##     Min      1Q  Median      3Q     Max  ## -1.2228 -0.2991 -0.0211  0.3462  1.2114  ##  ## Coefficients: ##                       Estimate Std. Error t value Pr(>|t|)     ## (Intercept)            3.10928    0.34095    9.12  6.2e-13 *** ## prenatalprenatal       3.28305    0.07267   45.18  < 2e-16 *** ## sra_attribute.RIN     -0.00449    0.03444   -0.13   0.8968     ## sra_attribute.sexmale  0.10582    0.06705    1.58   0.1197     ## assigned_gene_prop    -0.96639    0.28639   -3.37   0.0013 **  ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## Residual standard error: 0.547 on 60 degrees of freedom ## Multiple R-squared:  0.973,  Adjusted R-squared:  0.971  ## F-statistic:  545 on 4 and 60 DF,  p-value: <2e-16 plot(m1, which=2, col=(as.numeric(mydf$prenatalprenatal)+1), pch=19)"},{"path":"/articles/S5b_nonlin.html","id":"logistic-curve-with-response-decreasing-in-x","dir":"Articles","previous_headings":"","what":"Logistic curve with response decreasing in x","title":"S5b: hypothesis testing in nonlinear regression","text":"Let denote asymptotic response large values x b denote response x=0. c denote slope-like parameter, d midpoint transition asymptotes.  variety S-shaped curves can produced depending choices parameters. Exercise: Increase value parameter c, recompute y, overlay plot lines() lty=2.","code":"a = 4 b = 1 c = 0.8 d = 4.5 x = 0:10 y = a + (b-a)/(1+exp(-c*(x-d))) plot(x,y,type=\"b\", ylim=c(0,5))"},{"path":"/articles/S5b_nonlin.html","id":"fitting-the-model-to-data","dir":"Articles","previous_headings":"","what":"Fitting the model to data","title":"S5b: hypothesis testing in nonlinear regression","text":"nls function can fit model. data crafted illustrate “pair” curves can regarded shifted instances common shape. color distinguishes elements pair.  modeling pair experiments red points arise different condition black points. null hypothesis curves identical tested using parameter ‘del’ measuring shift response curve. indicator variable z takes value 0 control condition 1 active treatment. Let’s use model overlay predicted response curves original data.  summary, evidence shift, location inflection point shifted 0.24 units x, p-value 0.079. seems clear model fits one condition much better . Exercise: abline function can used sketch aspects model plot just given. example, abline(h=4.4419, lty=2) draws dashed line representing fitted upper asymptote. Use estimated , b, d parameters draw “cross-hairs” showing location inflection point black curve, filling appropriate values abline(v=?, h=?). Exercise (advanced): Test hypothesis two conditions different asymptotic values x increases.","code":"library(CSHstats) data(nonlindat) plot(y~x,data=nonlindat, col=nonlindat$z+1, pch=19) nl1 <- nls(y ~   a + ((b - a)/(1 + exp(-c * (x - d*(1+del*z))))),   start = list(a = min(y), b = max(y), c = 1,   d = round(median(x)), del=0), data=nonlindat) summary(nl1) ##  ## Formula: y ~ a + ((b - a)/(1 + exp(-c * (x - d * (1 + del * z))))) ##  ## Parameters: ##     Estimate Std. Error t value Pr(>|t|)     ## a     4.4419     0.6008   7.393 1.37e-05 *** ## b     0.4829     0.9835   0.491 0.633037     ## c     0.7281     0.4401   1.654 0.126290     ## d     4.3314     0.7326   5.912 0.000101 *** ## del   0.2412     0.1244   1.939 0.078521 .   ## --- ## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ##  ## Residual standard error: 0.4515 on 11 degrees of freedom ##  ## Number of iterations to convergence: 14  ## Achieved convergence tolerance: 4.863e-06 plot(y~x,data=nonlindat, col=nonlindat$z+1, pch=19) nd = data.frame(x=1:8,z=0) y1 = predict(nl1, newdata=nd) lines(1:8, y1, lty=2) nd2 = data.frame(x=1:8,z=1) y2 = predict(nl1, newdata=nd2) lines(1:8, y2, lty=2, col=\"red\")"},{"path":"/articles/S6_hca_onto.html","id":"road-map","dir":"Articles","previous_headings":"","what":"Road map","title":"S6 HCA, ontologies, shiny","text":"Bioconductor reads paper ontoProc rols help ontologies shiny helps communicate","code":""},{"path":"/articles/S6_hca_onto.html","id":"a-paper-on-the-atlas-of-the-prostate","dir":"Articles","previous_headings":"","what":"A paper on the atlas of the prostate","title":"S6 HCA, ontologies, shiny","text":"overview normals","code":""},{"path":[]},{"path":"/articles/S6_hca_onto.html","id":"surveying-projects-of-the-hca","dir":"Articles","previous_headings":"A paper on the atlas of the prostate > The hca package","what":"Surveying projects of the HCA","title":"S6 HCA, ontologies, shiny","text":"","code":"library(hca) p = projects(size = 200); p = dplyr::bind_rows(p, hca_next(p)) # workaround bug upstream to 1.4.0 library(DT) datatable(as.data.frame(p))"},{"path":"/articles/S6_hca_onto.html","id":"picking-a-project-enumerating-and-downloading-loom-files","dir":"Articles","previous_headings":"A paper on the atlas of the prostate > The hca package","what":"Picking a project; Enumerating and downloading loom files","title":"S6 HCA, ontologies, shiny","text":"","code":"projectId = \"53c53cd4-8127-4e12-bc7f-8fe1610a715c\" file_filter <- filters(     projectId = list(is = projectId),     fileFormat = list(is = \"loom\") ) pfile = files(file_filter) pfile$projectTitle[1] ## [1] \"A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra\" #pfile |> files_download()"},{"path":"/articles/S6_hca_onto.html","id":"working-with-loom","dir":"Articles","previous_headings":"A paper on the atlas of the prostate > The hca package","what":"Working with loom","title":"S6 HCA, ontologies, shiny","text":"superficial filtering (60000 cells) development PCA code blocked bucket made available filtered data.","code":"library(LoomExperiment) f1 = import(\"/home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom\") f1 names(colData(f1)) library(scater) sf1 = as(f1, \"SingleCellExperiment\") sf1 library(scuttle) assay(sf1[1:4,1:4]) assayNames(sf1) = \"counts\" litsf1 = sf1[,1:60000] z = DelayedArray::rowSums(assay(litsf1)) mean(z==0) todrop = which(z==0) litsf2 = litsf1[-todrop,] assay(litsf2) litsf2 = logNormCounts(litsf2) litsf2 = runPCA(litsf2) library(SingleCellExperiment) if (!exists(\"litsf2\")) load(\"litsf2.rda\") # run code above, must have HDF5 in cache metadata(litsf2) > str(litsf2) # 22MB on disk (no quantifications) Formal class 'DelayedMatrix' [package \"DelayedArray\"] with 1 slot   ..@ seed:Formal class 'DelayedAperm' [package \"DelayedArray\"] with 2 slots   .. .. ..@ perm: int [1:2] 2 1   .. .. ..@ seed:Formal class 'DelayedSubset' [package \"DelayedArray\"] with 2 slots   .. .. .. .. ..@ index:List of 2   .. .. .. .. .. ..$ : int [1:60000] 1 2 3 4 5 6 7 8 9 10 ...   .. .. .. .. .. ..$ : int [1:23420] 13 20 22 23 31 33 34 35 36 37 ...   .. .. .. .. ..@ seed :Formal class 'HDF5ArraySeed' [package \"HDF5Array\"] with 7 slots   .. .. .. .. .. .. ..@ filepath : chr \"/home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom\"   .. .. .. .. .. .. ..@ name     : chr \"/matrix\"   .. .. .. .. .. .. ..@ as_sparse: logi FALSE   .. .. .. .. .. .. ..@ type     : chr NA   .. .. .. .. .. .. ..@ dim      : int [1:2] 382197 58347   .. .. .. .. .. .. ..@ chunkdim : int [1:2] 64 64   .. .. .. .. .. .. ..@ first_val: int 0 stvjc@stvjc-XPS-13-9300:~/CSAMA_HCA$ ls -tl /home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom -rw-rw-r-- 1 stvjc stvjc 1206062245 Jun 21 22:37 /home/stvjc/.cache/R/hca/36e582f7c6e_36e582f7c6e.loom"},{"path":"/articles/S6_hca_onto.html","id":"working-with-isee","dir":"Articles","previous_headings":"A paper on the atlas of the prostate > The hca package","what":"Working with iSEE","title":"S6 HCA, ontologies, shiny","text":"Question: “stop/exit” button? Question: can embed iSEE (components) vignette? iSEE server? context fgf2","code":""},{"path":"/articles/S6_hca_onto.html","id":"upshots","dir":"Articles","previous_headings":"A paper on the atlas of the prostate","what":"Upshots","title":"S6 HCA, ontologies, shiny","text":"easy survey HCA hca package easy get experiments, metadata, quantifications projects interest iSEE really accelerates exploration elaboration data claims","code":""},{"path":[]},{"path":"/articles/S6_hca_onto.html","id":"definition-from-wikipedia","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"Definition: from Wikipedia","title":"S6 HCA, ontologies, shiny","text":"computer science information science, ontology encompasses representation, formal naming, definition categories, properties, relations concepts, data, entities substantiate one, many, domains discourse. simply, ontology way showing properties subject area related, defining set concepts categories represent subject. Every academic discipline field creates ontologies limit complexity organize data information knowledge. uses ontological assumptions frame explicit theories, research applications. New ontologies may improve problem solving within domain. Translating research papers within every field problem made easier experts different countries maintain controlled vocabulary jargon languages.","code":""},{"path":"/articles/S6_hca_onto.html","id":"applications-in-genomics","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"Applications in genomics","title":"S6 HCA, ontologies, shiny","text":"Gene Ontology: Genes gene products subdomains BP, MF, CC – biological process, molecular function, cellular component Human Phenotype Ontology UBERON - cross-species anatomy Cell ontology Cell line ontology EFO - experimental factor ontology Tags can encountered various annotation resources.","code":""},{"path":"/articles/S6_hca_onto.html","id":"rols-basic-idea","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"rols: Basic idea","title":"S6 HCA, ontologies, shiny","text":"OLS ontology lookup service API rols package help interrogate service ontologies everywhere","code":""},{"path":"/articles/S6_hca_onto.html","id":"learn-about-smooth-muscle-with-rols","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"Learn about ‘smooth muscle’ with rols","title":"S6 HCA, ontologies, shiny","text":"","code":"library(rols) ss = OlsSearch(\"smooth muscle\", rows=100) ss ## Object of class 'OlsSearch': ##   query: smooth muscle  ##   requested: 100 (out of 54384) ##   response(s): 0 tt = olsSearch(ss) dd = as(tt, \"data.frame\") datatable(dd)"},{"path":"/articles/S6_hca_onto.html","id":"ontoproc-capitalizing-on-ontologyindex-thanks-daniel-greene-rgraphviz-thanks-kasper-hansen","dir":"Articles","previous_headings":"Ontologies, EBI OLS, rols (thanks Laurent Gatto!), ontoProc::ctmarks","what":"ontoProc – capitalizing on ontologyIndex (thanks Daniel Greene!), Rgraphviz (thanks Kasper Hansen!)","title":"S6 HCA, ontologies, shiny","text":"ctmarks app: walk linked ontologies PR present additional facets concept focus Limitation: OBO representation use outdated -links sparse Projects: - use rols get interesting information terms app - update ontology resources - go beyond OBO … way OWL? Evaluate UI/UX needed broaden ontology usage - impacts: data integration, precision annotation, cognitive efficiency","code":"library(ontoProc) co = getOnto(\"cellOnto\") ## loading from cache head(co$name) ##              BFO:0000002              BFO:0000003              BFO:0000004  ##             \"continuant\"              \"occurrent\" \"independent continuant\"  ##              BFO:0000006              BFO:0000015              BFO:0000016  ##         \"spatial region\"                \"process\"            \"disposition\" chk = ctmarks(co)"},{"path":[]},{"path":"/articles/S7_cnn.html","id":"introductory-remarks","dir":"Articles","previous_headings":"","what":"Introductory remarks","title":"S7 Neural net concepts and applications","text":"learning nonlinear regression model putting use input, output, loss function excellent high level overview comparing convolutional neural nets autoencoders","code":""},{"path":"/articles/S7_cnn.html","id":"road-map","dir":"Articles","previous_headings":"","what":"Road map","title":"S7 Neural net concepts and applications","text":"ImageArray ISLR (also python version Convolutional Neural Net example (also see Jeremy Jordan Sfaira model zoo embeddings classifiers","code":""},{"path":"/articles/S7_cnn.html","id":"images-and-categories","dir":"Articles","previous_headings":"","what":"Images and categories","title":"S7 Neural net concepts and applications","text":"can filter ImageArray  Question bias: machine recognize orange just “orange” color distribution? “normalize” images “object ” presents “essential features”?","code":"library(littleDeep) data(ciftrain1k) ciftrain1k ## ImageArray instance with 1000 images, each 32 x 32 x 3 ##  Image types: possum lion ... caterpillar girl  ##  Array elements range from 0.000000 to 255.000000. n <- preview(ciftrain1k) preview(filterByType(ciftrain1k, \"orange\")) ## NULL"},{"path":"/articles/S7_cnn.html","id":"a-trained-classifier-that-ingests-jpgs-as-arrays-and-returns-scores-for-resemblance-to","dir":"Articles","previous_headings":"","what":"A trained classifier that ingests JPGs as arrays and returns scores for resemblance to","title":"S7 Neural net concepts and applications","text":"pre-trained categories Check ’ll demonstrate ‘jpeg_shrinker’ installed intel macs M1 macs time. program convert jpeg image 32x32 resolution use trained CNN classify content.","code":"islr_cnn ## function (iarr, nEpochs = 30, batchSize = 128, valSplit = 0.2)  ## { ##     reticulate::import(\"keras\") ##     ca = match.call() ##     stopifnot(inherits(iarr, \"ImageArray\")) ##     arr = getArray(iarr) ##     d = dim(arr)[-1] ##     stopifnot(all(d == c(32, 32, 3))) ##     denom = max(arr) ##     yclass = getTypes(iarr) ##     yclass = as.numeric(factor(yclass)) ##     yclass = yclass - min(yclass) ##     trainxy = list(train = list(x = arr, y = yclass)) ##     ncat = length(unique(trainxy$train$y)) ##     model <- keras_model_sequential() %>% layer_conv_2d(filters = 32,  ##         kernel_size = c(3, 3), padding = \"same\", activation = \"relu\",  ##         input_shape = c(32, 32, 3)) %>% layer_max_pooling_2d(pool_size = c(2,  ##         2)) %>% layer_conv_2d(filters = 64, kernel_size = c(3,  ##         3), padding = \"same\", activation = \"relu\") %>% layer_max_pooling_2d(pool_size = c(2,  ##         2)) %>% layer_conv_2d(filters = 128, kernel_size = c(3,  ##         3), padding = \"same\", activation = \"relu\") %>% layer_max_pooling_2d(pool_size = c(2,  ##         2)) %>% layer_conv_2d(filters = 256, kernel_size = c(3,  ##         3), padding = \"same\", activation = \"relu\") %>% layer_max_pooling_2d(pool_size = c(2,  ##         2)) %>% layer_flatten() %>% layer_dropout(rate = 0.5) %>%  ##         layer_dense(units = 512, activation = \"relu\") %>% layer_dense(units = ncat,  ##         activation = \"softmax\") ##     model %>% compile(loss = \"categorical_crossentropy\", optimizer = optimizer_rmsprop(),  ##         metrics = c(\"accuracy\")) ##     history <- model %>% fit(trainxy$train$x/denom, to_categorical(trainxy$train$y,  ##         ncat), epochs = nEpochs, batch_size = batchSize, validation_split = valSplit) ##     curver = packageVersion(\"littleDeep\") ##     ans = list(model = model, history = history, typelevels = typelevels(iarr),  ##         littleDeepVersion = curver, call = ca, date = Sys.Date()) ##     class(ans) = c(\"islr_cnn\", \"list\") ##     ans ## } ## <bytecode: 0x130cafe28> ## <environment: namespace:littleDeep>"},{"path":"/articles/S7_cnn.html","id":"sfaira-a-model-zoo-of-pretrained-embedders-and-cell-type-classifiers-from-theis-lab","dir":"Articles","previous_headings":"","what":"Sfaira: a model zoo of pretrained embedders and cell-type classifiers from Theis Lab","title":"S7 Neural net concepts and applications","text":"’ll look pkgdown site, specifically “get started” tab.","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Road map","title":"distances, nearest-neighbor graphs, clustering","text":"Distances high-dimensional spaces Criteria agglomerative clustering interactive heatmap comparing Euclidean correlation (1-cor) distances comparing agglomeration methods silhouette measure clustering adequacy bluster tools cluster diagnostics Grun pancreas data NNGraphParam","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Cluster analysis concepts","title":"distances, nearest-neighbor graphs, clustering","text":"need identify groups similar observations arises many contexts – ultimately service clarifying sources variability, building power statistical comparisons. Hierarchical clustering N multivariate observations conducted starting N clusters proceeding M clusters M-1 (M=N, …, 2) clusters merging two members separated least pairwise distances.","code":""},{"path":[]},{"path":[]},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Application: inferring steps in tumor metastasis in a breast cancer patient","title":"distances, nearest-neighbor graphs, clustering","text":"’ll examine data distributed 2021 Genome Biology paper Gabor Marth lab. Clinical sequence interventions. Event sequence.","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"A view of copy number aberrations for 1Mb tiling","title":"distances, nearest-neighbor graphs, clustering","text":"28 tumors sampled sequenced rapid autopsy procedure. Copy number variation assessed using FACETS. tissues tumors taken Br (Breast), Bo (Bone), Bn (Brain), Ln (Lung), Lv (Liver), Pa (Pancreas), Ly (Lymph nodes), Kd (Kidney) plotly-based visualization (vertical) ordering tissues chosen exemplify certain similarities. example block blue chr10 seen three samples. indication deletion.","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"A cluster analysis proposed in support of the evolutionary map","title":"distances, nearest-neighbor graphs, clustering","text":"code lightly modified script distributed https://github.com/xiaomengh/tumor-evo-rapid-autopsy.git.","code":"suppressPackageStartupMessages({  library(csamaDist)  library(bioDist)  library(bluster)  library(cluster)  library(scater)  library(scran)  library(scRNAseq)  library(scuttle) }) data(cnv_log_R) data = cnv_log_R samples = c('Ln7','Ln9','Ln1','BrM','BrP',            'Ln11','Ly2','Ln3',            'Bo3','Ln10','Bo1','Ln8','Lv3','Ln5','Bo2','Bn2','Bn1','Bn3','Bn4','Ln2',            'Ly1','Ln6',            'Kd1','Ln4','Lv4','Lv2','Lv1','Pa1') rownames(data) = samples d = dist(data, method=\"euclidean\") fit = hclust(d, method=\"average\") # the following line changes the order of the samples to produce the Fig.S3B but doesn't change the phylogenetic relationship fit$order = c(1,4,2,5,3,13,10,20,16,11,12,15,9,17,19,14,18,21,22,7,6,8,25,27,26,28,23,24) plot(fit)"},{"path":[]},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"Comparing Euclidean and Correlation distances","title":"distances, nearest-neighbor graphs, clustering","text":"given correlation distance value, can wide variation euclidean distance, vice versa. Open question: distance metric relevant biological interpretation CNV?","code":"cd = cor.dist(cnv_log_R) # from bioDist ed = dist(cnv_log_R) plot(as.numeric(ed), as.numeric(cd), xlab=\"All pairwise Euclidean distances\", ylab=\"All pairwise correlation distances\")"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"A pair with discrepant correlation and euclidean distance values (over entire genome)","title":"distances, nearest-neighbor graphs, clustering","text":"’ll look first 100Mb chr1.","code":"plot(cnv_log_R[\"Ly1\",1:100],pch=19, main=\"chr1, first 100Mb\", ylab=\"FACETS CNV log R\", xlab=\"chr1\") points(cnv_log_R[\"Ln1\",1:100], col=\"red\",pch=19) legend(60, -.5, pch=19, col=c(\"black\", \"red\"), legend=c(\"Ly1\", \"Ln1\")) #cor(cnv_log_R[\"Ly1\", 1:100], cnv_log_R[\"Ln1\", 1:100]) edist = function(x,y) sqrt(sum((x-y)^2)) edist(cnv_log_R[\"Ly1\", 1:100], cnv_log_R[\"Ln1\", 1:100]) ## [1] 1.685992 plot(jitter(cnv_log_R[\"Ly1\", 1:100]), cnv_log_R[\"Ln1\", 1:100], xlab=\"Ly1\", ylab=\"Ln1\") abline(0,1)"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"Redo clustering with alternative distance and agglomeration method","title":"distances, nearest-neighbor graphs, clustering","text":"","code":"fit2 = hclust(cd, method=\"ward.D2\") plot(fit2) abline(h=.3, lty=2)"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"Silhouette measure","title":"distances, nearest-neighbor graphs, clustering","text":"?silhouette cluster library:","code":"For each observation i, the _silhouette width_ s(i) is defined as follows:       Put a(i) = average dissimilarity between i and all other points of      the cluster to which i belongs (if i is the _only_ observation in      its cluster, s(i) := 0 without further calculations).  For all      _other_ clusters C, put d(i,C) = average dissimilarity of i to all      observations of C.  The smallest of these d(i,C) is b(i) := \\min_C      d(i,C), and can be seen as the dissimilarity between i and its      \"neighbor\" cluster, i.e., the nearest one to which it does _not_      belong.  Finally,                     s(i) := ( b(i) - a(i) ) / max( a(i), b(i) ).                     'silhouette.default()' is now based on C code donated by Romain      Francois (the R version being still available as      'cluster:::silhouette.default.R').       Observations with a large s(i) (almost 1) are very well clustered,      a small s(i) (around 0) means that the observation lies between      two clusters, and observations with a negative s(i) are probably      placed in the wrong cluster. ct1 = cutree(fit2, h=.3) c2 = cnv_log_R rownames(c2) = paste(rownames(c2), as.numeric(ct1)) sil = silhouette(ct1, cd) plot(sil)"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"Drilling down on the clustering","what":"Exercises","title":"distances, nearest-neighbor graphs, clustering","text":"1: install bioDist vjcitn/csamaDist. Use code: Comment qualitative differences clusterings. 2: produce report silhouette measurement second clustering. Produce three-cluster partition hc1 obtain silhouette display.","code":"library(csamaDist) data(cnv_log_R) hc1 = hclust(dist(cnv_log_R[1:8,])) hc2 = hclust(bioDist::cor.dist(cnv_log_R[1:8,]), method=\"ward.D2\")  opar = par(no.readonly=TRUE) par(mfrow=c(1,2), mar=c(4,3,1,1)) plot(hc1, main=\"Euc, complete\") plot(hc2, main=\"1-Cor, Ward's D2\") par(opar) assn =  cutree(hc2, h=.25) plot(silhouette( assn, bioDist::cor.dist(cnv_log_R[1:8,])))"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Clustering single cell RNA-seq","title":"distances, nearest-neighbor graphs, clustering","text":"code taken verbatim bluster “diagnostics” vignette.","code":""},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Acquire Grun et al’s single cell RNA-seq dataset","title":"distances, nearest-neighbor graphs, clustering","text":"[Grun 2016] (https://www.sciencedirect.com/science/article/pii/S1934590916300947) define algorithm, StemID, infers candidate multipotent cell populations human pancreas.","code":"library(scRNAseq) sce <- GrunPancreasData() ## snapshotDate(): 2022-04-26 ## see ?scRNAseq and browseVignettes('scRNAseq') for documentation ## loading from cache ## snapshotDate(): 2022-04-26 ## see ?scRNAseq and browseVignettes('scRNAseq') for documentation ## loading from cache # Quality control to remove bad cells. library(scuttle) qcstats <- perCellQCMetrics(sce) qcfilter <- quickPerCellQC(qcstats, sub.fields=\"altexps_ERCC_percent\") ## Warning in .get_med_and_mad(metric, batch = batch, subset = subset, ## share.medians = share.medians, : missing values ignored during outlier detection sce <- sce[,!qcfilter$discard]  # Normalization by library size. sce <- logNormCounts(sce)  # Feature selection. library(scran) dec <- modelGeneVar(sce) hvgs <- getTopHVGs(dec, n=1000)  # Dimensionality reduction. set.seed(1000) library(scater) sce <- runPCA(sce, ncomponents=20, subset_row=hvgs) sce <- runTSNE(sce, subset_row=hvgs)"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Clustering using a nearest-neighbor graph; visualization via TSNE and PCA","title":"distances, nearest-neighbor graphs, clustering","text":"bluster’s makeSNNGraph help page","code":"The 'makeSNNGraph' function builds a shared nearest-neighbour    graph using observations as nodes. For each observation, its 'k'    nearest neighbours are identified using the 'findKNN' function,    based on distances between their expression profiles (Euclidean by    default). An edge is drawn between all pairs of observations that    share at least one neighbour, weighted by the characteristics of    the shared nearest neighbors - see \"Weighting Schemes\" below.     The aim is to use the SNN graph to perform clustering of    observations via community detection algorithms in the 'igraph'    package. This is faster and more memory efficient than    hierarchical clustering for large numbers of observations. In    particular, it avoids the need to construct a distance matrix for    all pairs of observations. Only the identities of nearest    neighbours are required, which can be obtained quickly with    methods in the 'BiocNeighbors' package. library(bluster) mat <- reducedDim(sce) clust.info <- clusterRows(mat, NNGraphParam(), full=TRUE) clusters <- clust.info$clusters table(clusters) ## clusters ##   1   2   3   4   5   6   7   8   9  10  11  12  ## 285 171 161  59 174  49  70 137  69  65  28  23 plot(reducedDims(sce)$TSNE, col=clusters, pch=19, main=\"TSNE\") plot(reducedDims(sce)$PCA, col=clusters, pch=19, main=\"PCA\") pairs(reducedDims(sce)$PCA[,1:4], col=clusters, pch=19, main=\"PCA\")"},{"path":"/articles/distplus.html","id":null,"dir":"Articles","previous_headings":"","what":"Assessment via pairwiseModularity","title":"distances, nearest-neighbor graphs, clustering","text":"","code":"g <- clust.info$objects$graph ratio <- pairwiseModularity(g, clusters, as.ratio=TRUE)  cluster.gr <- igraph::graph_from_adjacency_matrix(log2(ratio+1),      mode=\"upper\", weighted=TRUE, diag=FALSE)  # Increasing the weight to increase the visibility of the lines. set.seed(1100101) plot(cluster.gr, edge.width=igraph::E(cluster.gr)$weight*5,     layout=igraph::layout_with_lgl)"},{"path":"/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Vince Carey. Author, maintainer.","code":""},{"path":"/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Carey V (2024). CSHstats: discussions exercises classical statistics CSHL 2022. R package version 0.0.34, https://github.com/vjcitn/CSHstats.","code":"@Manual{,   title = {CSHstats: discussions and exercises on classical statistics for CSHL 2022},   author = {Vince Carey},   year = {2024},   note = {R package version 0.0.34},   url = {https://github.com/vjcitn/CSHstats}, }"},{"path":"/index.html","id":"cshstats","dir":"","previous_headings":"","what":"discussions and exercises on classical statistics for CSHL 2022","title":"discussions and exercises on classical statistics for CSHL 2022","text":"R vignettes/pkgdown elementary statistics summer course One view conceptual scheme course three main vertices:  students start lower left vertex need move along bottom edge work high-dimensional data generated sequencing technologies. Ultimately want use data climb edges expand biological medical knowledge. ’ll conduct introductory exploration four topic areas statistics data science: Probability simulation Exploratory data analysis visualization Hypothesis testing Linear models Ontology branch information science Brief introduction convolutional neural nets TBD: MultiAssayExperiment applications SingleCellMultimodal (convenience) CITEseq TENx MultiOme seqFISH","code":""},{"path":"/reference/accex.html","id":null,"dir":"Reference","previous_headings":"","what":"MultiAssayExperiment instance for ACC — accex","title":"MultiAssayExperiment instance for ACC — accex","text":"MultiAssayExperiment instance ACC","code":""},{"path":"/reference/accex.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"MultiAssayExperiment instance for ACC — 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diff --git a/docs/sitemap.xml b/docs/sitemap.xml
index 735a79f..1d6aaf4 100644
--- a/docs/sitemap.xml
+++ b/docs/sitemap.xml
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diff --git a/vignettes/S6_hca_onto.Rmd b/vignettes/S6_hca_onto.Rmd
index 6568cc6..dfaf13f 100644
--- a/vignettes/S6_hca_onto.Rmd
+++ b/vignettes/S6_hca_onto.Rmd
@@ -88,8 +88,8 @@ litsf2 = logNormCounts(litsf2)
 litsf2 = runPCA(litsf2)
 ```
 
-Whatchaget:
-```{r lkstuf}
+This code is blocked until a bucket is made available with the filtered data.
+```{r lkstuf, eval=FALSE}
 library(SingleCellExperiment)
 if (!exists("litsf2")) load("litsf2.rda") # run code above, must have HDF5 in cache
 metadata(litsf2)