diff --git a/Lib/test/libregrtest/utils.py b/Lib/test/libregrtest/utils.py
index 7675fbe16a21416..6af949cea9c9265 100644
--- a/Lib/test/libregrtest/utils.py
+++ b/Lib/test/libregrtest/utils.py
@@ -310,16 +310,8 @@ def get_build_info():
     elif '-flto' in ldflags_nodist:
         optimizations.append('LTO')
 
-    # --enable-optimizations
-    pgo_options = (
-        # GCC
-        '-fprofile-use',
-        # clang: -fprofile-instr-use=code.profclangd
-        '-fprofile-instr-use',
-        # ICC
-        "-prof-use",
-    )
-    if any(option in cflags_nodist for option in pgo_options):
+    if support.check_cflags_pgo():
+        # PGO (--enable-optimizations)
         optimizations.append('PGO')
     if optimizations:
         build.append('+'.join(optimizations))
diff --git a/Lib/test/pythoninfo.py b/Lib/test/pythoninfo.py
index f16b7986995c38a..c372efaedd313ba 100644
--- a/Lib/test/pythoninfo.py
+++ b/Lib/test/pythoninfo.py
@@ -956,6 +956,16 @@ def collect_tempfile(info_add):
 
     info_add('tempfile.gettempdir', tempfile.gettempdir())
 
+
+def collect_libregrtest_utils(info_add):
+    try:
+        from test.libregrtest import utils
+    except ImportError:
+        return
+
+    info_add('libregrtests.build_info', ' '.join(utils.get_build_info()))
+
+
 def collect_info(info):
     error = False
     info_add = info.add
@@ -995,6 +1005,7 @@ def collect_info(info):
         collect_tkinter,
         collect_windows,
         collect_zlib,
+        collect_libregrtest_utils,
 
         # Collecting from tests should be last as they have side effects.
         collect_test_socket,
diff --git a/Lib/test/support/__init__.py b/Lib/test/support/__init__.py
index 0d9efe10c6504c2..8a4555ce16fbb6a 100644
--- a/Lib/test/support/__init__.py
+++ b/Lib/test/support/__init__.py
@@ -773,6 +773,21 @@ def python_is_optimized():
     return final_opt not in ('', '-O0', '-Og')
 
 
+def check_cflags_pgo():
+    # Check if Python was built with ./configure --enable-optimizations:
+    # with Profile Guided Optimization (PGO).
+    cflags_nodist = sysconfig.get_config_var('PY_CFLAGS_NODIST') or ''
+    pgo_options = (
+        # GCC
+        '-fprofile-use',
+        # clang: -fprofile-instr-use=code.profclangd
+        '-fprofile-instr-use',
+        # ICC
+        "-prof-use",
+    )
+    return any(option in cflags_nodist for option in pgo_options)
+
+
 _header = 'nP'
 _align = '0n'
 _vheader = _header + 'n'
diff --git a/Lib/test/test_tools/test_freeze.py b/Lib/test/test_tools/test_freeze.py
index 922e74b441457ab..671ec2961e7f8f5 100644
--- a/Lib/test/test_tools/test_freeze.py
+++ b/Lib/test/test_tools/test_freeze.py
@@ -15,6 +15,10 @@
 @support.requires_zlib()
 @unittest.skipIf(sys.platform.startswith('win'), 'not supported on Windows')
 @support.skip_if_buildbot('not all buildbots have enough space')
+# gh-103053: Skip test if Python is built with Profile Guided Optimization
+# (PGO), since the test is just too slow in this case.
+@unittest.skipIf(support.check_cflags_pgo(),
+                 'test is too slow with PGO')
 class TestFreeze(unittest.TestCase):
 
     @support.requires_resource('cpu') # Building Python is slow
diff --git a/Misc/NEWS.d/next/Tests/2023-09-20-02-32-17.gh-issue-103053.AoUJuK.rst b/Misc/NEWS.d/next/Tests/2023-09-20-02-32-17.gh-issue-103053.AoUJuK.rst
new file mode 100644
index 000000000000000..9940982bb28db2d
--- /dev/null
+++ b/Misc/NEWS.d/next/Tests/2023-09-20-02-32-17.gh-issue-103053.AoUJuK.rst
@@ -0,0 +1,4 @@
+Skip test_freeze_simple_script() of test_tools.test_freeze if Python is
+built with Profile Guided Optimization (PGO): it just makes the test too
+slow. The freeze tool is tested by many other CIs with other (faster)
+compiler flags. Patch by Victor Stinner.