Drug Screening Hits

What is HTS data ?

Cell lines are created from patients for the advantage many drugs can be tested on these cell lines in the lab (in-vitro). Drug response data in the form of EC50 values can be obtained for each for multiple doses which allows us to see which drugs a patient cell line is sensitive to

This R Shiny app - DrugScreeningHits

• Allows user to set a drug response value cut off that determines if a cell line is sensitive or not
• Lists the drugs that are sensitive
• Allows to input one or more HTS files (i.e. more than one patient HTS data) Shows drugs at are sensitive in “intersection” of files Shows drugs at are sensitive in “union” of files

Front page screenshot

After input data is uploaded

Link to shiny app

Link: https://krithikab.shinyapps.io/DrugScreeningHits/

Input data format

Input data must be csv or excel with the following column names

• Sample ID
• Vendor Catalog
• Final EC50
• DRUGBANK_ID
• DRUGBANK_NAME
• Note - the first row is usually skipped so leave it blank

Test data

Test.csv - uploaded to this repo. This test data was mocked up as an example for demonstration purposes