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emdann authored Dec 15, 2023
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[badge-docs]: https://img.shields.io/readthedocs/oor_benchmark

One of the goals of reference-based single-cell RNA-seq analysis is to detect altered cell states that are not observed in the reference dataset.
This repository contains code to benchmark workflows for integration and differential analysis on the task of detection of Out-of-reference (OOR) states, used in our [preprint](https://www.biorxiv.org/content/10.1101/2022.11.10.515939v1) on reference design for disease state identification. For code to reproduce analysis in the manuscript see the [reproducibility repo](https://github.com/MarioniLab/oor_design_reproducibility).
This repository contains code to benchmark workflows for integration and differential analysis on the task of detection of Out-of-reference (OOR) states, used in our [paper](https://www.nature.com/articles/s41588-023-01523-7) on reference design for disease state identification. For code to reproduce analysis in the manuscript see the [reproducibility repo](https://github.com/MarioniLab/oor_design_reproducibility).

The structure of the API was inspired by the [OpenProblems](https://github.com/openproblems-bio/openproblems) task structure. This package was built using the [scverse cookiecutter template](https://github.com/scverse/cookiecutter-scverse).

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## Citation

> Dann E., Teichmann S.A. and Marioni J.C. Precise identification of cell states altered in disease with healthy single-cell references. _biorXiv_ https://doi.org/10.1101/2022.11.10.515939
> Dann E., Cujba A.M., Oliver A.J., Meyer K., Teichmann S.A. and Marioni J.C. Precise identification of cell states altered in disease with healthy single-cell references. _Nature Genetics_ https://doi.org/10.1038/s41588-023-01523-7
[scverse-discourse]: https://discourse.scverse.org/
[issue-tracker]: https://github.com/emdann/oor_benchmark/issues
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