Counterfactual Confounder Adjustment (CoCoA) for single-cell RNA-seq differential expression analysis

(Logo by Elise Park)

Simulation experiments

• Simulation results focusing on power comparison (Fig. 2, Supplementary Fig. 1)

• Simulation results focusing on sample size

• Simulation results testing empirical FDR (Fig. 2, Supplementary Fig. 1)

• Simulating results testing the sensitivity of kNN parameters (Fig. 2, Supplementary Fig. 1)

• Simulation results used in Supplementary Fig. 2

Alzheimer's disease case study

• Differential Expression Analysis (Fig. 3)

• Gene ontology enrichment for DEGs (Fig. 4)