Probiotics (Lactobacilli) to prevent Clostridium difficile associated diarrhea

This repository contains the source data and matching forest plots for an open meta-analysis of this intervention. This repository updates a previously published meta-analysis.(1)

Details of the studies included are in the evidence table.

This meta-analysis suggests that clinical intervention is effective. As compared to the most recent meta-analysis below, below, this living meta-analysis adds more recent randomized data.

References:

Systematic review(s)

####Most recent review at time of last revision of this repository

1. Goldenberg JZ, Ma SS, Saxton JD, Martzen MR, Vandvik PO, Thorlund K, Guyatt GH, Johnston BC. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2013 May 31;5:CD006095. PMID: 23728658

Randomized controlled trials

New trial(s) not included in the most recent review above

1. Allen SJ, Wareham K, Wang D, Bradley C, Hutchings H, Harris W, Dhar A, Brown H, Foden A, Gravenor MB, Mack D. Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. 2013 Oct 12;382(9900):1249-57. PMID: (23932219)[http://pubmed.gov/23932219]

Trials included in the review above