Here are instructions for setting up a good Python build on CentOS/RH.
SPADE requires build-essential, python-tk, python-vtk, python-pmw, python-numpy, and python-scipy. I installed all those on linux mint with apt-get. Then install biopython with "sudo pip install biopython".
$ python SPADE.py
$ python MolecularViewer.py
Close SPADE then cd into the Applications folder. Clone the AlignmentEditor github repo into a folder named AlignmentEditor. Then start SPADE.
Windows installer here. This version has limited functionality.