generate finalized neut curves and ICXX dfs

experiments/validations_hk19/ic50_fold_changes.csv

@@ -0,0 +1,44 @@
+serum,variant,log2_fold_change_ic50
+2365,Y159N,1.1587803758152246
+2365,T160K,0.08919007102579339
+2365,T160K-Y159N,1.1440518156939397
+2365,K189E,2.199497198556672
+2365,S193D,1.856389159786079
+2365,S145H,-0.3007835409333092
+3856,Y159N,-1.7816451659814099
+3856,T160K,-2.11717757600622
+3856,T160K-Y159N,-0.9285257888724228
+3856,K189E,-0.008476547763267561
+3856,S193D,-0.4780453032029789
+3856,E50K,-0.7392865588227644
+3857,Y159N,1.3325341119008263
+3857,T160K,-3.3812435721837577
+3857,K189E,1.5108663647754605
+3857,S193D,1.7465677091391039
+3857,E50K,0.15507516829582713
+3857,T160S,0.105868267946878
+4584,T160K,-1.7027020934795827
+4584,K189E,-0.10519890421354913
+4584,S193D,-0.6360228095022644
+4584,E50K,3.988970477906854
+197C,Y159N,-1.0568745446497974
+197C,T160K,-2.018230767148386
+197C,T160K-Y159N,-1.2970370658478159
+197C,K189E,0.6878925069742432
+197C,S193D,1.0594866241511853
+197C,S145K,1.897758904730533
+74C,Y159N,1.326125857856724
+74C,T160K,-1.2656232731908994
+74C,T160K-Y159N,0.46457945298447334
+74C,K189E,0.35240136866462296
+74C,S193D,2.1220665084391537
+74C,S145K,1.3914780653673868
+3944,Y159N,1.3235149637734391
+3944,T160K,1.1894524672916686
+3944,T160K-Y159N,2.273689515598467
+3944,K189E,3.0159397498140548
+3944,S193D,2.634269964695827
+3944,S193Y,0.14039247443211203
+3944,S145H,0.06231406134083265
+3944,S145K,1.5001802340874237
+3944,T160S,0.2917935440206944

experiments/validations_hk19/ic80_fold_changes.csv

@@ -0,0 +1,44 @@
+serum,variant,log2_fold_change_ic80
+2365,Y159N,1.2917866397798279
+2365,T160K,0.24384126543094795
+2365,T160K-Y159N,1.284644933372007
+2365,K189E,2.1124202114943587
+2365,S193D,2.001675451635799
+2365,S145H,-0.17859695739976733
+3856,Y159N,-0.7067389684992818
+3856,T160K,-1.7009275118298919
+3856,T160K-Y159N,-1.2801173617482342
+3856,K189E,0.0422432836978997
+3856,S193D,0.29154925305574125
+3856,E50K,-0.3158716305053015
+3857,Y159N,0.39112270138355365
+3857,T160K,-3.2723779870770273
+3857,K189E,1.74453415543376
+3857,S193D,1.3575014324413637
+3857,E50K,0.17208726856186987
+3857,T160S,0.10950523373060196
+4584,T160K,-1.2066956557211215
+4584,K189E,-0.046675205228060436
+4584,S193D,-0.06036824714258388
+4584,E50K,3.8716661132104484
+197C,Y159N,-0.37972647135921805
+197C,T160K,-2.051716495887036
+197C,T160K-Y159N,-1.2770849113961327
+197C,K189E,0.7878928812450896
+197C,S193D,0.9796085148315293
+197C,S145K,1.6310076039003594
+74C,Y159N,0.9731601670416832
+74C,T160K,-1.2732901401881898
+74C,T160K-Y159N,0.4818567574239039
+74C,K189E,0.4922380209365971
+74C,S193D,1.7383580773905105
+74C,S145K,1.52128540836638
+3944,Y159N,1.3696742718582298
+3944,T160K,0.6884750283537515
+3944,T160K-Y159N,1.9571634888934473
+3944,K189E,2.9397336058752708
+3944,S193D,2.5572587143585497
+3944,S193Y,-0.07078394268594405
+3944,S145H,0.18420072784516786
+3944,S145K,1.1027272061913982
+3944,T160S,0.11586752806366517

experiments/validations_hk19/ic90_fold_changes.csv

@@ -0,0 +1,44 @@
+serum,variant,log2_fold_change_ic90
+2365,Y159N,1.36959031656014
+2365,T160K,0.33430641484970053
+2365,T160K-Y159N,1.3668866350731521
+2365,K189E,2.0614834393871235
+2365,S193D,2.0866624842367147
+2365,S145H,-0.10712238794141218
+3856,Y159N,-0.07795915117946729
+3856,T160K,-1.4574368333639653
+3856,T160K-Y159N,-1.485785247450153
+3856,K189E,0.0719124831455796
+3856,S193D,0.7417332092262303
+3856,E50K,-0.06818977519404933
+3857,Y159N,-0.15956767152006066
+3857,T160K,-3.2086957021705227
+3857,K189E,1.881221050595226
+3857,S193D,1.1299122502779841
+3857,E50K,0.1820387092760134
+3857,T160S,0.11163272233048592
+4584,T160K,-0.91655048951614
+4584,K189E,-0.012441035918057017
+4584,S193D,0.27636808520687717
+4584,E50K,3.3943825936581664
+197C,Y159N,0.016379758951351655
+197C,T160K,-2.071304391508467
+197C,T160K-Y159N,-1.2654136492333015
+197C,K189E,0.8463893502516151
+197C,S193D,0.9328828162510256
+197C,S145K,1.4749680958961195
+74C,Y159N,0.7666884738737465
+74C,T160K,-1.277774969879621
+74C,T160K-Y159N,0.49196333263451353
+74C,K189E,0.5740372187420859
+74C,S193D,1.513903034016505
+74C,S145K,1.5972178363390401
+3944,Y159N,1.3966757361470679
+3944,T160K,0.39542201286774753
+3944,T160K-Y159N,1.7720076327687475
+3944,K189E,2.8951558693465236
+3944,S193D,2.512210020777593
+3944,S193Y,-0.1943142277366561
+3944,S145H,0.2554998570881096
+3944,S145K,0.8702320890741442
+3944,T160S,0.012957405827531883