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Hi there 👋

Fulcrum Genomics Speaks Biology.

We are bioinformaticians, computational biologists, and software engineers with experience in basic research, technology development, diagnostics, therapeutics and beyond. Talk to us about your problem –- we’ll understand.

Below are Toolkits, Libraries, and Template Repositories that we've developed and use on a regular basis. We hope that you will find them useful too!

  • We prefer to publish under the MIT License; Forked repositories normally retain their original license and thus may be published under a different license.
  • We have a Code of Conduct

Toolkits 🛠️

Here are some toolkits we've developed:

  • fgbio: Tools for working with genomic and high throughput sequencing data in Scala.
  • fgsv: Tools to gather evidence for structural variation via breakpoint detection.
  • fqtk: Fast FASTQ sample demultiplexing in Rust.
  • fqgrep: Grep for FASTQ files.
  • stitch: Stitch is a toolkit for analysis of chimeric reads in sequencing data.
  • guide-counter: A better, faster way to count guides in CRISPR screens.
  • bwa: A fork of bwa to run interactively and work with bwa on the command line.

Libraries 📚

Here are some libraries that we use regularly in our work:

  • Python
    • fgpyo: Quality of life improvements for Bioinformatics in Python.
    • pybedlite: Lightweight interfaces for reading, writing, and querying Genomic Regions (BED) in Python.
    • prymer: APIs and wrappers for performing PCR primer design and related tasks in Python.
  • Rust
    • fgoxide: Quality of life improvements for Bioinformatics in Rust.
    • read-structure: Read structures in Rust.
    • pooled-writer: A pooled writer and compressor library in Rust.
    • bgzf: High level readers and writers for the BGZF format in Rust.
  • Scala
    • fgprimer: APIs and wrappers for performing PCR primer design and related tasks in Scala.
    • sopt: An argument parsing library for Scala.
    • commons: A collection of useful libraries for Scala.
  • GitHub Actions
    • setup-latch: A GitHub action for building and register Latch Bio workflows.

Template Repositories 🏁

Here are some template repositories we use when we start something new:

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  1. fgbio fgbio Public

    Tools for working with genomic and high throughput sequencing data.

    Scala 315 67

  2. fqgrep fqgrep Public

    Grep for FASTQ files

    Rust 93 4

  3. guide-counter guide-counter Public

    A better, faster way to count guides in CRISPR screens.

    Rust 27 3

  4. fqtk fqtk Public

    Fast FASTQ sample demultiplexing in Rust.

    Rust 57 1

  5. pybedlite pybedlite Public

    Lightweight Python interfaces for reading, writing, and querying Genomic Regions (BED)

    Python 12

  6. fgoxide fgoxide Public

    Quality of life improvements in Rust.

    Rust 4 3

Repositories

Showing 10 of 43 repositories
  • prymer Public

    Python Primer Design Library

    fulcrumgenomics/prymer’s past year of commit activity
    Python 8 MIT 0 28 (2 issues need help) 2 Updated Nov 12, 2024
  • Sniffles Public Forked from fritzsedlazeck/Sniffles

    Structural variation caller using third generation sequencing

    fulcrumgenomics/Sniffles’s past year of commit activity
    Python 0 95 0 0 Updated Nov 4, 2024
  • fgsv Public

    Tools to gather evidence for structural variation via breakpoint detection.

    fulcrumgenomics/fgsv’s past year of commit activity
    Scala 19 MIT 1 9 1 Updated Nov 1, 2024
  • fgbio Public

    Tools for working with genomic and high throughput sequencing data.

    fulcrumgenomics/fgbio’s past year of commit activity
  • regtools Public Forked from griffithlab/regtools

    Integrate DNA-seq and RNA-seq data to identify mutations that are associated with regulatory effects on gene expression.

    fulcrumgenomics/regtools’s past year of commit activity
    C++ 0 MIT 27 0 5 Updated Oct 31, 2024
  • fgpyo Public

    Quality of life improvements for Bioinformatics in Python.

    fulcrumgenomics/fgpyo’s past year of commit activity
    Python 27 3 27 (1 issue needs help) 7 Updated Oct 24, 2024
  • sopt Public

    An argument parsing library for Scala

    fulcrumgenomics/sopt’s past year of commit activity
    Scala 10 MIT 0 4 2 Updated Oct 4, 2024
  • commons Public

    Common scala utilities

    fulcrumgenomics/commons’s past year of commit activity
    Scala 4 MIT 3 10 (1 issue needs help) 2 Updated Oct 4, 2024
  • pooled-writer Public

    A pooled writer and compressor library in Rust.

    fulcrumgenomics/pooled-writer’s past year of commit activity
    Rust 4 MIT 0 0 0 Updated Oct 4, 2024
  • guide-counter Public

    A better, faster way to count guides in CRISPR screens.

    fulcrumgenomics/guide-counter’s past year of commit activity
    Rust 27 MIT 3 8 1 Updated Oct 4, 2024

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