Implementations

Here are the open-source implementations of the MME API that we are aware of:

1. MME reference server: https://github.com/MatchmakerExchange/reference-server. This implementation provides a concrete but simple example of one method for performing phenotype and gene-level matchmaking using an elasticsearch index.
2. Monarch Initiative: https://github.com/monarch-initiative/monarch-mme. This is an adapter that implements the MME API on top of existing Monarch APIs.
3. PhenomeCentral: https://github.com/phenotips/remote-matching. This package extends PhenoTips and PhenomeCentral to support the MME API.
4. seqr: https://github.com/macarthur-lab/matchbox. This software was developed for the Broad Center for Mendelian Genomics by the MacArthur Lab of the Broad Institute of MIT and Harvard and is currently used by them in production. It is distributed with the BSD clause-3 license. Please contact [email protected] for any questions or help with installing this software.
5. PatientMatcher: https://github.com/Clinical-Genomics/patientMatcher. Developed and used in production by Clinical Genomics, SciLifeLab Stockholm. A Python web application using Flask framework and MongoDB that implements the MME API and allows to customize the patient matching algorithm.