Revised 5 definitions; fixes #28762

src/ontology/go-edit.obo

@@ -79292,7 +79292,7 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i
 id: GO:0008467
 name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
 namespace: molecular_function
-def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23]
+def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+. The (heparan sulfate)-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23]
 synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23]
 synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" RELATED [EC:2.8.2.23]
 synonym: "3-OST-1 activity" RELATED [EC:2.8.2.23]
@@ -79303,6 +79303,7 @@ synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED []
 synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23]
 xref: EC:2.8.2.23
 xref: MetaCyc:2.8.2.23-RXN
+xref: RHEA:15461 {source="skos:broadMatch"}
 is_a: GO:0034483 ! heparan sulfate sulfotransferase activity
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28762" xsd:anyURI
 
@@ -127882,7 +127883,7 @@ replaced_by: GO:0008236
 id: GO:0017095
 name: heparan sulfate 6-O-sulfotransferase activity
 namespace: molecular_function
-def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808]
+def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 6-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+." [PMID:8631808]
 synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT []
 synonym: "heparin 6-O-sulfotransferase activity" RELATED []
 is_a: GO:0034483 ! heparan sulfate sulfotransferase activity
@@ -198126,7 +198127,7 @@ is_a: GO:0008146 ! sulfotransferase activity
 id: GO:0033871
 name: [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity
 namespace: molecular_function
-def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29]
+def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+. Modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29]
 synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29]
 synonym: "3-OST-2" RELATED [EC:2.8.2.29]
 synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" RELATED [EC:2.8.2.29]
@@ -198137,14 +198138,15 @@ synonym: "heparin-glucosamine 3-sulfotransferase 2 activity" RELATED []
 synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29]
 xref: EC:2.8.2.29
 xref: MetaCyc:2.8.2.29-RXN
+xref: RHEA:15461 {source="skos:broadMatch"}
 is_a: GO:0034483 ! heparan sulfate sulfotransferase activity
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28762" xsd:anyURI
 
 [Term]
 id: GO:0033872
 name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity
 namespace: molecular_function
-def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate." [EC:2.8.2.30]
+def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+." [EC:2.8.2.30]
 synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30]
 synonym: "3-OST-3" RELATED [EC:2.8.2.30]
 synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" RELATED [EC:2.8.2.30]
@@ -198155,6 +198157,7 @@ synonym: "heparin-glucosamine 3-sulfotransferase 3 activity" RELATED []
 synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30]
 xref: EC:2.8.2.30
 xref: MetaCyc:2.8.2.30-RXN
+xref: RHEA:15461 {source="skos:broadMatch"}
 is_a: GO:0034483 ! heparan sulfate sulfotransferase activity
 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28762" xsd:anyURI
 
@@ -290779,7 +290782,7 @@ is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and de
 id: GO:0047464
 name: heparosan-N-sulfate-glucuronate 5-epimerase activity
 namespace: molecular_function
-def: "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN]
+def: "Catalysis of the reaction: (heparosan-N-sulfate)(n) = (heparan-N-sulfate)(n). Converts D-glucosyluronate residues to L-iduronate residues." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN]
 synonym: "C-5 uronosyl epimerase activity" RELATED [EC:5.1.3.17]
 synonym: "D-glucuronyl C-5 epimerase activity" RELATED [EC:5.1.3.17]
 synonym: "heparosan epimerase activity" RELATED [EC:5.1.3.17]