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sv-linx v1.5

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@charlesshale charlesshale released this 31 Oct 18:34
· 15935 commits to master since this release

Functional changes:

  • Fusion likelihood calcs - implemented gene-pairs, skip non-coding same-gene fusions
  • known fusions don't require upstream transcript to be disruptive but will still fail on chain termination
  • TIs limited by min of achor distances now less sum of breakend homologies
  • BFB_AMP does not require max ploidy x8
  • dominant foldback must exceed ploidy 4
  • DMs can have a single SV and need to be 5x sample ploidy or 2.3x telomere/centromere
  • dissolve simple groups unless all SVs in LOH or all assembled
  • set intronic transcripts from LINE clusters to be non-disruptive

Bugs:

  • only reconfigure chains for RECIP_INV_DUPs if can form positive TI
  • determination of unique non-reported fusions was skipping first element