sv-linx v1.5
charlesshale
released this
31 Oct 18:34
·
15935 commits
to master
since this release
Functional changes:
- Fusion likelihood calcs - implemented gene-pairs, skip non-coding same-gene fusions
- known fusions don't require upstream transcript to be disruptive but will still fail on chain termination
- TIs limited by min of achor distances now less sum of breakend homologies
- BFB_AMP does not require max ploidy x8
- dominant foldback must exceed ploidy 4
- DMs can have a single SV and need to be 5x sample ploidy or 2.3x telomere/centromere
- dissolve simple groups unless all SVs in LOH or all assembled
- set intronic transcripts from LINE clusters to be non-disruptive
Bugs:
- only reconfigure chains for RECIP_INV_DUPs if can form positive TI
- determination of unique non-reported fusions was skipping first element