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Merge pull request #529 from hlxsites/507-metadata-helix-query-update
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507 Update on metadata and product index
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@rgravitvl
rgravitvl authored Nov 30, 2023
2 parents ee556c2 + 6670731 commit 50f3677
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3 changes: 3 additions & 0 deletions helix-query.yaml
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image:
select: head > meta[property="og:image"]
value: match(attribute(el, "content"), "^(https?:\/\/.*?(danaher.com))+(.*)|^(.*)")
opco:
select: head > meta[name="opco"]
value: attribute(el, "content")
type:
select: head > meta[name="template"]
value: attribute(el, "content")
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157 changes: 157 additions & 0 deletions tools/actions/convert/test/fixtures/product-category2-converted.html
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<html>
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<div class="breadcrumb">
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<div>
<ul>
<li><a href="/us/en/products.html">Products</a></li>
<li><a href="/us/en/products/centrifuges.html">Centrifuges</a></li>
<li><a href="/us/en/products/centrifuges/analytical-ultracentrifuges.html">Analytical Ultracentrifuges</a></li>
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<div class="banner">
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<h1>Analytical Ultracentrifuges</h1>
<h2>Our analytical ultracentrifuge (AUC) allows real-time monitoring of particle behavior during sedimentation. A specialized centrifuge equipped with integrated optical detection systems, it enables precise analysis of the molecular weight, hydrodynamic, and thermodynamic properties of proteins or macromolecules without the need for calibration standards</h2>
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<p>Analytical ultracentrifugation stands as a first-principle technique performed in a matrix-free environment. It eliminates the need for calibration standards and is unmatched by other methods in providing a comprehensive range of information with exceptional precision and accuracy. In addition, analytical ultracentrifugation molecular weight determination is considered the definitive approach for determining the molecular weight of proteins in solution, offering researchers valuable insights into molecues' size, shape, and behavior. With sedimentation velocity and sedimentation equilibrium measurements, our AUC offers complementary perspectives on solution properties, including molar masses, stoichiometries, association constants, and nonideality.</p>
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<h2><strong>FEATURES</strong></h2>
<h2>Essential Features of Our Analytical Ultracentrifuge</h2>
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<li>
<p><strong>Performance:</strong> Analytical ultracentrifugation is widely recognized as the gold standard technique for studying macromolecules, including proteins and viruses like adeno-associated viruses (AAVs). AUC enables researchers to investigate the behavior and properties of macromolecules at various concentrations. Additionally, AUC can utilize optical detection systems, including absorbance measurements, to monitor the behavior of macromolecules in real time. With its ability to characterize macromolecules and study molecular interactions at different concentrations, analytical ultracentrifugation for AAV and proteins remains an indispensable tool offering valuable insights into their behavior and properties.</p>
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<p><strong>Quality:</strong> Analytical ultracentrifugation enables the analysis of macromolecules in solutions, such as proteins, across a range of protein concentrations. By studying macromolecules in their native state, AUC preserves their natural conformation and behavior, ensuring that the data obtained accurately represents their true characteristics. This feature of AUC is crucial for obtaining high-quality and reliable results.</p>
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<p><strong>Durability:</strong> Instruments for modern analytical ultracentrifugation in protein science are a viable addition and investment to the research labs. AUC instruments are specifically designed to withstand the rigorous demands of ultracentrifugation, which involves high speeds and forces. These instruments are constructed with robustness in mind, incorporating reliable components and advanced technology to ensure long-term durability. This longevity allows AUC instruments to deliver high-performance results over extended periods consistently.</p>
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<h2><strong>APPLICATIONS</strong></h2>
<h2>Applications</h2>
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<p>Analytical ultracentrifugation finds applications in cell culture optimization by analyzing the extracellular vesicles (EVs) derived from cell cultures. AUC can be utilized to characterize the size distribution and concentration of EVs, providing valuable information about their secretion dynamics and potential functional properties.</p>
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<p>This AUC can investigate biomolecular interactions, including protein-protein interactions and protein-ligand interactions. By analyzing the sedimentation behavior and association constants of macromolecules in solution, AUC provides insights into the strength and dynamics of these interactions. This information aids in understanding molecular recognition processes and optimizing the design of therapeutic agents in gene therapy solutions.</p>
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<p>Our AUC can provide valuable information in nanoparticle characterization by validating and confirming nanoparticle size. AUC can be used to accurately determine the size distribution of nanoparticles in a solution, providing orthogonal data to complement other sizing methods. By analyzing the sedimentation behavior of nanoparticles, AUC offers precise insights into their size, shape, and density, helping researchers validate the size measurements obtained from other techniques.</p>
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<h2><strong>FAQs</strong></h2>
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<h3>Compared to other techniques, what is the advantage of using analytical ultracentrifugation for protein studies?</h3>
<p>One key advantage is that AUC allows for the analysis of proteins in their native state, preserving their natural conformation and behavior in solution. Additionally, AUC provides a comprehensive analysis of proteins, including information on molecular weight, hydrodynamic properties, and solution behavior, all in a single experiment.</p>
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<h3>What types of molecules can be studied using analytical ultracentrifugation?</h3>
<p>Analytical ultracentrifugation (AUC) can be used to study a wide range of molecules, including proteins, nucleic acids, lipids, carbohydrates, polymers, and complexes thereof.</p>
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<h3>What type of information can be obtained from sedimentation velocity and sedimentation equilibrium in analytical ultracentrifugation?</h3>
<p>Sedimentation velocity in AUC provides first-principle, hydrodynamic information about the size and shape of molecules, while sedimentation equilibrium provides insights into solution molar masses, stoichiometries, association constants, and solution nonideality, offering a comprehensive understanding of macromolecular properties and interactions.</p>
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<h3>How is an analytical ultracentrifuge different from a high-speed preparative centrifuge, and what advantages does it offer?</h3>
<p>An analytical ultracentrifuge differs from a high-speed preparative centrifuge by incorporating an integrated optical detection system that allows real-time monitoring of particles in the sample as they undergo sedimentation. The optical systems, such as UV-Vis absorbance and Rayleigh interference, enable precise observation of the solution behavior of molecules. This real-time monitoring, coupled with advanced software, enables comprehensive analysis of the molecules in the sample, providing valuable insights into their properties and behavior.</p>
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<h3>How does the analytical ultracentrifuge contribute to the study of biomolecular interactions?</h3>
<p>The analytical ultracentrifuge plays a crucial role in studying biomolecular interactions by providing quantitative information about their association constants, stoichiometries, and solution nonideality. By analyzing the sedimentation behavior of macromolecules in solution, the analytical ultracentrifuge offers valuable insights into the strength and dynamics of biomolecular interactions, enabling researchers to understand molecular recognition processes and optimize the design of therapeutic agents or drug-target interactions.</p>
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<h2>Need help designing your solution?</h2>
<p><a href="#request-quote">Request a Quote</a></p>
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<div>style</div>
<div>bg-danaherlightblue-50</div>
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<div>Title</div>
<div>Analytical Ultracentrifuges (AUCs) | Danaher Life Sciences</div>
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<div>canonical</div>
<div><a href="https://lifesciences.danaher.com/us/en/products/centrifuges/analytical-ultracentrifuges.html">https://lifesciences.danaher.com/us/en/products/centrifuges/analytical-ultracentrifuges.html</a></div>
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<div>keywords</div>
<div>Beckman Coulter</div>
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<div>Tags</div>
<div>danaher:opco/beckman-coulter</div>
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<div>OpCo</div>
<div>Beckman Coulter</div>
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<div>Description</div>
<div>Our high-performance AUCs offer comprehensive insights into macromolecules. Know their advantages for protein studies, nanoparticle characterization &#x26; more.</div>
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<div>Image</div>
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<img src="https://author-p93411-e849602.adobeaemcloud.com/content/dam/danaher/products/Analytical-Ultrafuge/analytical-ultracentrifuges-card.jpg" alt="">
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<div>creationDate</div>
<div>Fri, 21 Jul 2023 18:49:31 GMT</div>
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<div>updateDate</div>
<div>Thu, 30 Nov 2023 13:27:30 GMT</div>
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