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743 Updated for time line page #744

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merged 8 commits into from
Feb 5, 2024
Merged

743 Updated for time line page #744

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342abf4
Updated for time line page
rgravitvl Feb 5, 2024
89dfb40
updated lint issues
rgravitvl Feb 5, 2024
e05dd5b
Merge branch 'main' into 743-converter-update-timeline-cards
rgravitvl Feb 5, 2024
ab3ee65
changed the order and updated the headings
rgravitvl Feb 5, 2024
45ab0c9
Merge branch 'main' into 743-converter-update-timeline-cards
rgravitvl Feb 5, 2024
5a029f0
Merge branch 'main' into 743-converter-update-timeline-cards
rgravitvl Feb 5, 2024
e828ebd
updated the element for subtitle
rgravitvl Feb 5, 2024
550e894
Merge branch '743-converter-update-timeline-cards' of https://github.…
rgravitvl Feb 5, 2024
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253 changes: 253 additions & 0 deletions tools/actions/convert/test/fixtures/solutions-process-steps-converted.html
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<html>
<body>
<header></header>
<main>
<div>
<div class="breadcrumb">
<div>
<div>
<ul>
<li><a href="/us/en/solutions.html">Solutions</a></li>
<li><a href="/us/en/solutions/mabs.html">Monoclonal Antibody (MAbs)</a></li>
<li><a href="/us/en/solutions/mabs/cell-line-development.html">Cell Line Development (CLD)</a></li>
<li><a href="/us/en/solutions/mabs/cell-line-development/process-steps.html">Cell Line Development Process Steps</a></li>
</ul>
</div>
</div>
</div>
<hr>
<div class="banner">
<div>
<div>
<h1>Cell Line Development Process Steps</h1>
</div>
</div>
</div>
<div class="page-jump-menu">
<div>
<div>:dam-Bookmark:</div>
<div><a href="/us/en/solutions/mabs/cell-line-development.html">Overview</a></div>
</div>
<div>
<div>:dam-Refresh:</div>
<div><a href="/us/en/solutions/mabs/cell-line-development/process-steps.html">Process Steps</a></div>
</div>
<div>
<div>:dam-Cube:</div>
<div><a href="/us/en/solutions/mabs/cell-line-development/products.html">Products</a></div>
</div>
<div>
<div>:dam-Chat:</div>
<div><a href="/us/en/solutions/mabs/cell-line-development/talk-to-expert.html">Talk to an Expert</a></div>
</div>
</div>
<h3>Cell Line Development Workflow Solutions - One lab, three paths to faster outcomes</h3>
<div class="timeline-menu">
<div>
<div><strong>All</strong></div>
<div>
<p>Leverage an extensive portfolio and accelerate Cell Line Development.</p>
<p><a href="#">View Solution</a></p>
</div>
</div>
<div>
<div><strong>Laboratory Automation</strong></div>
<div>
<p>Increase workflow reproducibility and standardization with cutting edge tools</p>
<p><a href="#">View Solution</a></p>
</div>
</div>
<div>
<div><strong>Analytical Tools</strong></div>
<div>
<p>Gain critical insights faster with scalable solutions</p>
<p><a href="#">View Solution</a></p>
</div>
</div>
<div>
<div><strong>Digital Solutions</strong></div>
<div>
<p>Enterprise level workflow management, data handling and analyses</p>
<p><a href="#">View Solution</a></p>
</div>
</div>
</div>
<div class="timeline">
<div>
<div>1</div>
<div>
<p><em>LABORATORY AUTOMATION | DIGITAL SOLUTIONS</em></p>
<h2>Vector Construction</h2>
<p>Design sequences and assemble vectors for mAb expression. Confidently screen the created diversity of candidates and select the best hits.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/vector-construction.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/vector-construction.jpg" alt="">
</p>
</div>
</div>
<div>
<div>2</div>
<div>
<p><em>DIGITAL SOLUTIONS</em></p>
<h2>Sequence Verification</h2>
<p>Ensure vectors are ligated correctly and that the sequence of interest is intact, readying vectors for raising a new cell line.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/sequence-verification.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/sequence-verification.jpg" alt="">
</p>
</div>
</div>
<div>
<div>3</div>
<div>
<p><em>LABORATORY AUTOMATION | DIGITAL SOLUTIONS</em></p>
<h2>Stable Transfection &#x26; Selection</h2>
<p>Incorporate vectors into genomes, creating new cell lines expressing mAb candidates. Gently recover cells and begin maintaining cultures. Verify that the incorporated insert has not mutated during the transfection and recovery process.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/stable-transfection.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/stable-transfection.jpg" alt="">
</p>
</div>
</div>
<div>
<div>4</div>
<div>
<p><em>ANALYTICAL TOOLS | DIGITAL SOLUTIONS</em></p>
<h2>Pool Screening</h2>
<p>Examine newly raised cell lines for desirable attributes. Screen for product expression, cell viability, and division. Automate subsequent verification and selection steps.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/pool-screening.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/pool-screening.jpg" alt="">
</p>
</div>
</div>
<div>
<div>5</div>
<div>
<p><em>LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS</em></p>
<h2>Monoclonality Verification</h2>
<p>Verifying that cultures originate from a single cell is a critical regulatory step and eliminates product heterogeneity.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/monoclonality-verification.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/monoclonal-verification.jpg" alt="">
</p>
</div>
</div>
<div>
<div>6</div>
<div>
<p><em>LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS</em></p>
<h2>Selection Based on Stability/Expansion</h2>
<p>Grow and passage cell lines over time. Screen for and document product titer level and cell viability after each round of seeding and growth. Determine the most favorable media conditions and the hardiest clones. Advance with only the most robust cell lines and highest producers.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/selection-based-on-stability-expansion.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/selection-stability-expansion.jpg" alt="">
</p>
</div>
</div>
<div>
<div>7</div>
<div>
<p><em>DIGITAL SOLUTIONS</em></p>
<h2>Sequence Verification</h2>
<p>Verify that the genome inserts have no mutations or modifications compromising product activity or quality after the requisite growth period.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/sequence-verification.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/sequence-verification.jpg" alt="">
</p>
</div>
</div>
<div>
<div>8</div>
<div>
<p><em>LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS</em></p>
<h2>Antibody Characterization</h2>
<p>Analyze products for most desirable qualities, such as structure, glycosylation, binding activity, and stability.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/antibody-characterization.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/antibody-characterization.jpg" alt="">
</p>
</div>
</div>
<div>
<div>9</div>
<div>
<p><em>ANALYTICAL TOOLS | DIGITAL SOLUTIONS</em></p>
<h2>Scale up – Cell Growth/Expansion</h2>
<p>Move cultures from small volumes to bioreactors and gather data on how cell lines tolerate bioreactor stresses and volume scaling. Prioritize developing cultures with best counts and viability over time.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/scale-up-cell-growth-expansion.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/scale-up-growth-cell-growth-and-selection.jpg" alt="">
</p>
</div>
</div>
<div>
<div>10</div>
<div>
<p><em>DIGITAL SOLUTIONS</em></p>
<h2>Sequence Verification</h2>
<p>Higher volumes present more opportunities for cultures to evolve. Sequence cell lines after bioreactor scaling, continuing if no problematic mutations are present.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/sequence-verification.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/sequence-verification.jpg" alt="">
</p>
</div>
</div>
<div>
<div>11</div>
<div>
<p><em>LABORATORY AUTOMATION | ANALYTICAL TOOLS | DIGITAL SOLUTIONS</em></p>
<h2>Antibody Characterization</h2>
<p>Measure product characteristics before transferring cultures downstream, as changes in conditions could affect product expression and translation. Select final candidates for master cell banking and subsequent process development.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/antibody-characterization.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/antibody-characterization.jpg" alt="">
</p>
</div>
</div>
<div>
<div>12</div>
<div>
<p><em>LABORATORY AUTOMATION | DIGITAL SOLUTIONS</em></p>
<h2>GMP Master Cell Bank</h2>
<p>Preserve cell lines to create stocks for transfer to a process development laboratory. Cell banks must be preserved at precise time periods, ensuring quality for later stages of drug development.</p>
<p><a href="/us/en/solutions/mabs/cell-line-development/process-steps/gmp-master-cell-bank.html">Learn More</a></p>
<p>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/gmp-master-cell-bank.jpg" alt="">
</p>
</div>
</div>
</div>
<div class="metadata">
<div>
<div>Title</div>
<div>Cell Line Development Process Steps | Danaher Life Sciences</div>
</div>
<div>
<div>canonical</div>
<div><a href="https://lifesciences.danaher.com/us/en/solutions/mabs/cell-line-development/process-steps.html">https://lifesciences.danaher.com/us/en/solutions/mabs/cell-line-development/process-steps.html</a></div>
</div>
<div>
<div>Description</div>
<div>Enhance the cell line development process steps with laboratory automation &#x26; digital solutions &#x26; gain critical insights with analytical tools. Explore today!</div>
</div>
<div>
<div>Image</div>
<div>
<img src="https://author-dummy.adobeaemcloud.com/content/dam/danaher/solutions/cell-line-development/human-cells-dna-strand-background.jpg" alt="">
</div>
</div>
<div>
<div>creationDate</div>
<div>Thu, 13 Apr 2023 14:13:01 GMT</div>
</div>
<div>
<div>updateDate</div>
<div>Tue, 26 Sep 2023 11:02:22 GMT</div>
</div>
</div>
</div>
</main>
<footer></footer>
</body>
</html>
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