ILC SB screen

Introduction

This repository accompanies the paper "Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma", which describes the use of a Sleeping Beauty mutagenesis screen mice to identify novel drivers of Invasive Lobular Carcinoma (ILC), the second most common subtype of human breast cancer.

Here we provide the files and code needed to reproduce the computational analyses performed in the paper.

Documentation

Documentation is available at https://jrderuiter.github.io/ilc-sb-screen.

Reference

Kas, S.M., de Ruiter, J.R., Schipper, K. et al. "Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma", Nature Genetics, 2017. In press.

Contact

Please ask questions about technical issues here on GitHub. Correspondence concerning the paper should be addressed to Jos Jonkers or Lodewyk Wessels.