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relationship between an intrinsic neuron and its neuropil of innervation #754

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Clare72 opened this issue Aug 17, 2023 · 1 comment · May be fixed by #755
Open

relationship between an intrinsic neuron and its neuropil of innervation #754

Clare72 opened this issue Aug 17, 2023 · 1 comment · May be fixed by #755
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@Clare72
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Clare72 commented Aug 17, 2023

Ideally, intrinsic neurons have all of their synapses restricted to a particular region of the CNS. In real life there may be a few stray synapses just outside the region.

Label: 'synapses restricted to region'
Exact synonym: 'intrinsic to'
Definition: 'A relationship between a neuron and a region, where the neuron has essentially all of its synapses in that region.'
Comment: 'Relationship may still be used if a very small number of synapses fall slightly outside the boundaries of the region.'
Parent: RO:0013001 ('has synaptic IO in region')
Domain: CL:0000540 ('neuron') - will be inherited from 'has synaptic terminal in'

I don't think we want to make this a subproperty of input and output relationships, in case there are neurons that do not have one or the other - some sensory neurons might not have synaptic inputs(?)

related to FlyBase/drosophila-anatomy-developmental-ontology#1626
@Clare72 Clare72 self-assigned this Aug 17, 2023
@Clare72 Clare72 linked a pull request Aug 17, 2023 that will close this issue
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addiehl commented Sep 11, 2023

Suggested that text definition be based on parent property phrasing (per David OS):

A relationship between a neuron and a region, where all of the functionally relevant input and output synapses are in that region.

Add a comment that any class using this relation should not have another restriction using this relation to a non-overlapping region.

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add 'synapses restricted to region' oborel/obo-relations
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