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Thoughts on adding motif results to amino acid similarity? #530

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n-hal opened this issue Jul 18, 2024 · 1 comment
Open

Thoughts on adding motif results to amino acid similarity? #530

n-hal opened this issue Jul 18, 2024 · 1 comment

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@n-hal
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n-hal commented Jul 18, 2024

I.e. in when clustering TCRs on amino-acid similarity it might be nice to return a string that encapsulates the conserved sequence, with a wild-card character (maybe %D:N, for example suggesting that substitutions between D:N in the blosum matrix would be tolerated in this group).

If this is of any interest I would be happy to contribute to it.

@grst
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grst commented Jul 18, 2024

Hi @n-hal,

in principle this is of interest. Could you elaborate whot that string would look like?

There's a long-standing request to add sequence logos #12 which might go into the same direction?

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