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Leaf is a powerful, fun, lightweight web application for querying clinical data. Leaf helps query clinical databases of nearly any data model for cohort estimation and data extraction. Leaf seamlessly integrates with clinical databases and existing enterprise authentication systems to unleash the potential of translational biomedical research.
Clinical databases are often the starting point for gathering data for nearly any kind biomedical research, whether in assessing feasibility of clinical trials, prep to research, retrospective research, or data science and machine learning. It's also often the case that academic medical centers have many more brilliant researchers, clinicians, and trainees eager to test hypotheses and use data than there are informaticians able to extract it.
Leaf is a simple drag-and-drop web application that queries clinical databases, so users can focus on accomplishing research, not waiting for data.
As an example, imagine a young researcher interested in studying low platelet counts in children diagnosed with congenital anomalies. She's interested in learning about patients at her institution, but may not have the funding to pay to extract the data, or the time to wait in line to request it.
With just Leaf and her laptop, it's easy for her to find the criteria:
Make a query:
And find her answer:
While Leaf can't solve every clinical data problem, it has enabled and helped hundreds of research and quality improvement projects at our institution, all while reducing the overall maintenance and support burden for our informatics teams. Here are a few projects that used Leaf:
- Risk Factors for Indeterminate Outcome on Interferon Gamma Release Assay in Non-US-Born Persons Screened for Latent Tuberculosis Infection
- PC040. Disease-Based Observational Cohort Study of Patients With Thoracoabdominal Aortic Aneurysm
- Left ventricular hypertrophy is a possible biomarker for early mortality after type B aortic dissection
- Safety of Expectant Management for Adhesive Small Bowel Obstruction: A Systematic Review
- IP003. Aortic Dissection-Related Mortality in Washington State Remains Unchanged From 1996 to 2016
- Trends in Washington State Aortic-Related Deaths Over a 21-Year Period, 1996-2016
- Washington State abdominal aortic aneurysm-related mortality shows a steady decline between 1996 and 2016
- Disease-Based Observation Cohort Study of Patients with Thoracoabdominal Aortic Aneurysm
- Demographic, clinical and immunologic correlates among a cohort of 50 cocaine users demonstrating anti-neutrophil cytoplasmic antibodies (currently in review)
- The Interferon Gamma Release Assay Is a Novel Predictor of Disease Activity in Systemic Lupus Erythematosus
- A Pharmacist Managed Titration of urate-lowering therapy to streamline gout management
A production Leaf instance is hosted at UW Medicine at the University of Washington in Seattle, USA. The Institute of Translational Health Sciences, also at the University of Washington and a key partner of our team, has a page about Leaf here https://www.iths.org/investigators/services/bmi/leaf if you are interested.
