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Re-assemble reads to the reference genome and determine haplotypes #154

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joergi-w opened this issue Sep 2, 2021 · 1 comment
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enhancement New feature or request

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joergi-w commented Sep 2, 2021

For an active region:

Create an assembly graph with the reference as template.
Take each read and match it to graph segments. Add new nodes if a part does not match.
Keep track how many reads support each path segment and determine the most likely paths.
Build haplotype sequences from likely paths.

@joergi-w joergi-w added the enhancement New feature or request label Sep 2, 2021
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joergi-w commented Sep 2, 2021

Use T-Coffee or parts of SViper for implementing this? (both SeqAn2)

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